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<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1G7</accession>
    <name>A0A0F4I1G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001829">
        <property type="protein sequence ID" value="KJY15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15870">
        <property type="protein sequence ID" value="KJY15870"/>
        <property type="gene ID" value="VR44_40725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8643" checksum="3B542B868883FC22" modified="2015-06-24" version="1" fragment="single">WGEVTDPAAEKLLAPTGWVKPDPKAYPTGGDWAERYLQPLADVLGDKVRLSARVTGVSRTGRDRIVDADREAQPFTVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I258</accession>
    <name>A0A0F4I258_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001867">
        <property type="protein sequence ID" value="KJY15774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15774">
        <property type="protein sequence ID" value="KJY15774"/>
        <property type="gene ID" value="VR44_40845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7605" checksum="7FE03FA454E811F8" modified="2015-06-24" version="1" fragment="single">AELRDRVTRDVTAARAEAQREVQAKREQADALFEETRAKAAQAAADFETHLAKRREQAERDLALRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I416</accession>
    <name>A0A0F4I416_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001775">
        <property type="protein sequence ID" value="KJY16213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16213">
        <property type="protein sequence ID" value="KJY16213"/>
        <property type="gene ID" value="VR44_40550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15973" checksum="51D6B2B8A20078CA" modified="2015-06-24" version="1" fragment="single">SAKTPAALRAQARRLRTHLAGHQEATPADIGYSLATGRAALQHRAAVLGTDRAELLRGLDALAEGAPEGAAPHLVTGSTDPAAGREPGRTAFLFSGQGSQRLGMGRELYEAFPVFADAFDACCAHLDGHLELPLREVVFGEDAELLDETRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I460</accession>
    <name>A0A0F4I460_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001771">
        <property type="protein sequence ID" value="KJY16258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16258">
        <property type="protein sequence ID" value="KJY16258"/>
        <property type="gene ID" value="VR44_40535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="9800" checksum="2BA9BFAC4783F0E3" modified="2015-06-24" version="1">MAGERLEGGEVGGAGGFDPFGQLVAFQLGEHAGERAHVCRQDVEFGACGQDSLELDSVWSGQSVGVGEDPPVTVRAVGGRRAMGRGLPRSTERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4I1</accession>
    <name>A0A0F4I4I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantetheine--protein transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001760">
        <property type="protein sequence ID" value="KJY16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16378">
        <property type="protein sequence ID" value="KJY16378"/>
        <property type="gene ID" value="VR44_40485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6894"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="11198" checksum="84A82966072755BA" modified="2015-06-24" version="1" fragment="single">EDSSADAYDLLTSQINDLRDDLSLDIDYLGLVVTLYDGRRGYIATSSLQAWMDIKDPRVVAIVPDLKEQRESVRLKQPLFVYAPNGDQAVALRALAREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9E0</accession>
    <name>A0A0F4I9E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001624">
        <property type="protein sequence ID" value="KJY18093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952558.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001624.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18093">
        <property type="protein sequence ID" value="KJY18093"/>
        <property type="gene ID" value="VR44_39695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6121"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469677" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15204" checksum="CA4FD3BCED757797" modified="2015-06-24" version="1">MNRLALLAAGATVLTALTAAPAFADTTPATPAETVTSCGPSGLQAGLSTRVCAEVTGTTVEFYGTVGLAGPPSPGSPAPEPKQLFTTLSVEVVGNDAPLVRQWPVVFTSSTVEVRGEAASASCGSTVRASFGVASFPWAARPVVHEVTLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGY2</accession>
    <name>A0A0F4IGY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001491">
        <property type="protein sequence ID" value="KJY20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20718">
        <property type="protein sequence ID" value="KJY20718"/>
        <property type="gene ID" value="VR44_38600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="1">
        <location>
            <begin position="109"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="879" mass="88642" checksum="E0F7CA413DEA6334" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP54</accession>
    <name>A0A0F4IP54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001353">
        <property type="protein sequence ID" value="KJY23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952086.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001353.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23820">
        <property type="protein sequence ID" value="KJY23820"/>
        <property type="gene ID" value="VR44_37165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4823"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="266"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="518" mass="53835" checksum="1ED1D3759BEFDB7A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQI1</accession>
    <name>A0A0F4IQI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001260">
        <property type="protein sequence ID" value="KJY24257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951845.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001260.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24257">
        <property type="protein sequence ID" value="KJY24257"/>
        <property type="gene ID" value="VR44_35890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4335"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="46452" checksum="5F0F2946CFF2A9E9" modified="2015-06-24" version="1">MTAADCAPRTARVLTGYRPEDGFMAAELDPPPPEYVWHDENAEQQDQRYGPGVGYRQWLAVDARSGAVWFGDTDWRAPQESPGSRIPGIPRRALGDGTVPGPGIMVQLLGHLSHDEQRGCTWHFFSAEELHALAERVLPAVQRLVDSIHRIGPAGELEWSAEAATAWDDIEQTATPAFDPSGELRWPLPRMTPVPAWRVEVGAFLDANPELCDPSWAVAADADLDAFADYQPATGYGGVPGRICHIAGRHIEDGFTFYGHRAALYAYRAQASGDRTPTDARTWLETTETGRSTWEAAKPPGANLADVSDCVLTDLTDRFQNTAREHGLVLTGLDTYLRTLRAEERAGVDQQLRFEGEEIERLENLLKDFRAGRNRTVARILAWSDGRSDAEIARLGSLSDEHVSQWRAHLNDEETGTPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRB2</accession>
    <name>A0A0F4IRB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001205">
        <property type="protein sequence ID" value="KJY24560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951686.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001205.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5734"/>
    <dbReference type="EnsemblBacteria" id="KJY24560">
        <property type="protein sequence ID" value="KJY24560"/>
        <property type="gene ID" value="VR44_35025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4079"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24082" checksum="1AE99673C825B592" modified="2015-06-24" version="1">MNQQLAGYAPTPVTARMENHGSAMLKVAMQSGQDLFARTGSMVAYEGFVQYEPNPPALRQRASQWLTGEGAPLMKCSGDGLLYLADYGANVVCINLNNDALSVNGTNLLAFDAHLQWGVERVKGMAKFAGQGLFNVQVSGTGWVAITSRGTPIVVDCGRGEDETFVDPDALVAWSPNLKVKGKSSFKASSLIGRGSGEAYQMAFSGQGIVVVQPSEDSTDRLRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISG7</accession>
    <name>A0A0F4ISG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001143">
        <property type="protein sequence ID" value="KJY24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24950">
        <property type="protein sequence ID" value="KJY24950"/>
        <property type="gene ID" value="VR44_33855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3695"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17253" checksum="A3DBF1BDB638C9A6" modified="2015-06-24" version="1" fragment="single">MIVMDGRELVRAVAEIGTARGRRAWRAALRHRRTDAEGLAPRGAERARVPGLLEGTEARPGGGVLRFARSELTVRVGVGGAVFWGWDGAGPEPSYAVLGGGPEPDARAVLEPDTGGGWRVVSERVTVAVSRHGAVEVRTPGGAVLRRELPPRWWDPVEGAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL3</accession>
    <name>A0A0F4ISL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001137">
        <property type="protein sequence ID" value="KJY24995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24995">
        <property type="protein sequence ID" value="KJY24995"/>
        <property type="gene ID" value="VR44_33730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3661"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="12512" checksum="AA698B01570D92C7" modified="2015-06-24" version="1" fragment="single">ASEASPSASASSKENGSSSAKKGVPHQVVFEVGGTGAAKVMWNGNSNHFDQVTLPWTKTEAMQLEGAELKVGVTVSVVPGSVTGPDGMLKPAPCTIKVDGKQVADNQEGKSPKPCEYKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISP7</accession>
    <name>A0A0F4ISP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">VR44_34620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="JZWV01001183">
        <property type="protein sequence ID" value="KJY24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001183.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3257"/>
    <dbReference type="EnsemblBacteria" id="KJY24679">
        <property type="protein sequence ID" value="KJY24679"/>
        <property type="gene ID" value="VR44_34620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3909"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="127"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="41485" checksum="B9750439CE8C26AA" modified="2015-06-24" version="1">MSAPNKSYDPVEVEALKPEEIERMRDEALAAFASAGDLDELREAKTAHMGDRSPLALANREIGALPPQAKAEAGKRVGQARGAVNKAFGARMAALEAERDERVLVEEAVDVTLPYDRVPAGARHPLTTLMDRIADIFVGMGYEVAEGPEVEAEWFNFDALNFTPDHPARQMQDTFFVQGPEGTTGDESGVVLRTHTSPVQARSLLERKPPVYIVCPGRVYRTDELDATHTPVFHQVELLAVDEGLTMADLKGTIDHMVKELFGEQTTTRLRPHFFPFTEPSAEMDMQCYVCRGESVGNPDRPCRTCSSEGWIELGGCGMVNPKVLVACGVDPEKYSGFAFGFGIERMLMFRHNVEDMRDMVEGDVRFTRPFGSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITE0</accession>
    <name>A0A0F4ITE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001174">
        <property type="protein sequence ID" value="KJY24743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951573.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001174.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene38"/>
    <dbReference type="EnsemblBacteria" id="KJY24743">
        <property type="protein sequence ID" value="KJY24743"/>
        <property type="gene ID" value="VR44_34425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3864"/>
    <dbReference type="eggNOG" id="ENOG5034423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7281" checksum="4A4073613BADE7B8" modified="2015-06-24" version="1">MKIDWAALGSVFGVSLSATVALVALFALGLVGLSKHEAATEQGGTATLARSGAYACFALCAAAVAYGIYLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITV5</accession>
    <name>A0A0F4ITV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_32525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001075">
        <property type="protein sequence ID" value="KJY25427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951231.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001075.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25427">
        <property type="protein sequence ID" value="KJY25427"/>
        <property type="gene ID" value="VR44_32525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3317"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="23417" checksum="1EB915E196AEE88D" modified="2015-06-24" version="1">MTWLNSEAFTAFGQKIIWSDAIGNTMGLIALALGWKRSIWTWPTQFLSGAILFVAFAAGHLSGNAGKQVVVMLVALWGWAQWTRGKRQAQDASLAVRFASWRERGLLLGAAAAGTLAVTGLFTLYPWMSWNPLPDAYIFVGTIVAMYAQAKGLVEFWFAWLLVDAVGVPLAFTSGYAFSAFVYVIYGALVLWGAYDWYQRSRTTPAPALEGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU25</accession>
    <name>A0A0F4IU25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001272">
        <property type="protein sequence ID" value="KJY24191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951885.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001272.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24191">
        <property type="protein sequence ID" value="KJY24191"/>
        <property type="gene ID" value="VR44_36100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4460"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469798" evidence="1">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="33420" checksum="0441619FE90EAB72" modified="2015-06-24" version="1">MRRARIRLATAATAAALALGTLPAAAYAAAAPATAARTRHHQLQPSSQAIRQIPLQGAVNLRDVGGYYTYSGGQVRQGLVYRSDALGKLTAADITTVSGLGLTKVVDFRIPMELQYDGADRLPPGLSPTSRPVSDLGLYGTLVGAISSGDPVKQEQMLGGGRAEAYMRDVYRTFVTSPENRAQFATTLREIADGGQGPLLYHCTSGKDRTGWMSYVLLRALGVPQETAGSDYLASNTFRAAYDAQVRAGLKQSGRMQNPDLLIPLQEVRQDYLDAATARMEADYGGFYGYLTDGLGLDLRTLAKLQNKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU38</accession>
    <name>A0A0F4IU38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001139">
        <property type="protein sequence ID" value="KJY24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951452.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001139.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24988">
        <property type="protein sequence ID" value="KJY24988"/>
        <property type="gene ID" value="VR44_33760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3671"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="15245" checksum="7057E4AC599FB452" modified="2015-06-24" version="1">MSDAAVEEDGQGLSGDLGGGEYAADCQARVAFEVLSNRWDSVIVYVLGESGPMRPRALITRIGGISPKVLNEALRRLEYNGLVARHAYAEAPPRVDYSLTEAGLALLGPIHAMGAWAGRYTEAVLAAQARFELREDRLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU93</accession>
    <name>A0A0F4IU93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001260">
        <property type="protein sequence ID" value="KJY24256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24256">
        <property type="protein sequence ID" value="KJY24256"/>
        <property type="gene ID" value="VR44_35885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4334"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14662" checksum="EE87EFC09FED8027" modified="2015-06-24" version="1" fragment="single">RDPVVAVVPARHRLAGREVIDLASLASETWIAAPEAALRLELLSQMAKTPGFQARLQYEGDDFNTVLGFVAAGLCVAVMPRLALPRTHTQVVARPLAEPRLTRFIYAVRIDTRHTPRAVLDLEGMLAAQALAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUG8</accession>
    <name>A0A0F4IUG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001040">
        <property type="protein sequence ID" value="KJY25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25652">
        <property type="protein sequence ID" value="KJY25652"/>
        <property type="gene ID" value="VR44_31900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3095"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="18915" checksum="59B75835782F1C8B" modified="2015-06-24" version="1" fragment="single">ADAWRRRLDAAWALLHRTVPEFARAATAGLSTLTPLAGGPRAQGWGEAGRHGPGALGVPYAAGVRETALALLTGRRRARLRALTEVADLYALDGAWQHPSPWRTRPVPVSRLLADVHERVAVEAYRRATTTQEPGGADRIHRALDHLSEAAELTVTGKRLVEELRWELKMVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUP6</accession>
    <name>A0A0F4IUP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001109">
        <property type="protein sequence ID" value="KJY25198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25198">
        <property type="protein sequence ID" value="KJY25198"/>
        <property type="gene ID" value="VR44_33135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3499"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470424" evidence="2">
        <location>
            <begin position="17"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="4">
        <location>
            <begin position="53"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="522"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="984" mass="105788" checksum="EEDC8599106126CD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV22</accession>
    <name>A0A0F4IV22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951202.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25469">
        <property type="protein sequence ID" value="KJY25469"/>
        <property type="gene ID" value="VR44_32400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3283"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="2">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16837" checksum="0F0CFC0466C18481" modified="2015-06-24" version="1">MASTKPNTEQYSGFTAEERAAMKDHAHEEKKAAARRGLSRAEKEAAAEQDVLAKIAEMPEADRVLAERIHEIIKAAAPELAPRLWYGMPAYARDGKVVCHFQSAEKFKSRYATLGFSDQAALDDGALWATSYAVTELTAAGEERIGALVRKAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVX9</accession>
    <name>A0A0F4IVX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000976">
        <property type="protein sequence ID" value="KJY26162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950901.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000976.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5082"/>
    <dbReference type="EnsemblBacteria" id="KJY26162">
        <property type="protein sequence ID" value="KJY26162"/>
        <property type="gene ID" value="VR44_30765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2609"/>
    <dbReference type="eggNOG" id="COG3831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="19558" checksum="5AA562255901D2CA" modified="2015-06-24" version="1">MDETEFWEIVDRTREAAGGDPEEHAELLVERLTQLDPDSVLDFARHFESRYNRAYTWDLWGAAWVLLDGASDDAFDYFRCWLIGQGREVFEGAVHDPDQLAELLGEFDEEIDGDGEELGYAADEAYEQLTGAVAPDLGIPLQAEEPEGAPLDFENEAVLAERFPRLWDRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWS9</accession>
    <name>A0A0F4IWS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000937">
        <property type="protein sequence ID" value="KJY26462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26462">
        <property type="protein sequence ID" value="KJY26462"/>
        <property type="gene ID" value="VR44_30020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2387"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="577" mass="61799" checksum="152E38788C2B765D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX69</accession>
    <name>A0A0F4IX69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000992">
        <property type="protein sequence ID" value="KJY26038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950938.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000992.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26038">
        <property type="protein sequence ID" value="KJY26038"/>
        <property type="gene ID" value="VR44_30960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2636"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470353" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6240" checksum="2399FA8B2B984534" modified="2015-06-24" version="1">MTIRQLPSLAAVAALAVLAGTATATPATAAARGATFSSDVVNFDRAAFSGSQVFSTAPSSPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX81</accession>
    <name>A0A0F4IX81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000962">
        <property type="protein sequence ID" value="KJY26259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26259">
        <property type="protein sequence ID" value="KJY26259"/>
        <property type="gene ID" value="VR44_30540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2523"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19616" checksum="AE1C4B03095BDC65" modified="2015-06-24" version="1" fragment="single">KAMPVSERFYLADAVFLAAVAGEEELIRTLHTAVRAPVYLPYLGRRSCPPQGPVDLGIREGDDAAAALRREPWYAAEWHQRRHSKQAHVPLQLLAEASADAPRGTPVRDQPVTFAPEHRRYALRNVVATVVDVLNPYFRPDEAHPTNESPRRVTVPRHSPEAHLALLPPQSPLDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY11</accession>
    <name>A0A0F4IY11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001058">
        <property type="protein sequence ID" value="KJY25551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951166.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene263"/>
    <dbReference type="EnsemblBacteria" id="KJY25551">
        <property type="protein sequence ID" value="KJY25551"/>
        <property type="gene ID" value="VR44_32205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3162"/>
    <dbReference type="eggNOG" id="ENOG502Z8K6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="519" mass="57273" checksum="C50B0F63EAEAAD30" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY63</accession>
    <name>A0A0F4IY63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001047">
        <property type="protein sequence ID" value="KJY25616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951136.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25616">
        <property type="protein sequence ID" value="KJY25616"/>
        <property type="gene ID" value="VR44_32035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3126"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031013">
        <property type="entry name" value="CGA_synth-rel"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04469">
        <property type="entry name" value="CGA_synth_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="21720" checksum="C6F646665D14C998" modified="2015-06-24" version="1" fragment="single">SPERALVRVHRPGWLPPSGPGARGARPTGILAPRRTGRNRTRSGTLVLLSLWGVPDAEAGTFASGTLRGLAAAALQRTGSCTVVADTGLASVRSALAANPGVRVLRAAEADPDALHAGAAVFLASPVLGALALAQARRAPLALLPPLGDAQRDLAAQVAEVLPLPSAEDPADPGLWAPPAAAGPWHLLDPALDDLRGAQRVARTLRQLALAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYN2</accession>
    <name>A0A0F4IYN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000867">
        <property type="protein sequence ID" value="KJY27135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000867.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27135">
        <property type="protein sequence ID" value="KJY27135"/>
        <property type="gene ID" value="VR44_28395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2004"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23005" checksum="A02223789A4A76F9" modified="2015-06-24" version="1" fragment="single">SLRSEDGSTTVDGLASDAVWEGLQYPEADFRADAKVLDGVELIGEGTIADRLWARPAVTVLGIDCPPVIGATPSVHASAGALISLRVPPGVDTAEAIKLLEAHLVAHTPWKARLELEVVGQGQPFQADTSSPAYASMAAALREAYDGQEMQISGMGGSIPLCNTLTSLYPQAEMLLIGLSEPEAQIHAVNESVSPEELERLSVAEALFLVNYAESKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZY3</accession>
    <name>A0A0F4IZY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine--scyllo-inositol aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950496.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27028">
        <property type="protein sequence ID" value="KJY27028"/>
        <property type="gene ID" value="VR44_28550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2039"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="41888" checksum="7F746DC1E727C043" modified="2015-06-24" version="1">MINLFQPQVGAEELDAVAGVFHDRRLGSGRRTKAFETAFAEHLGIEPDHVVFTSSGTTALHLAVETLDLQPGDEVVLPSLGLPATAEAVAGRGGRPVFCDVDRRTLNPSLEDVEAALTDRTRAVLFLHYGGRAGDILRIAARCRELGLALIEDGACSVASRVDGLPAGTFGDLAVWSFDPGRVLVTGDGGMVYAKDPERAARTRLLVRRGLVRASGFGHATLPGEPDLPEYGRGIAGNDLTAAIGSVQLRRLPEMVARRREIAARYDRELAGTEGLLTPPPLPEGHESTDCLYWVQLDPAIRDGVVADLLAEEIYTTSHHAPLHRFPAEGDAEPPAPPLPSCDWAVDRTVRLPLHPGLSDADVATVIDALRRSVRSRLASTDEGLTVKDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0B9</accession>
    <name>A0A0F4J0B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000805">
        <property type="protein sequence ID" value="KJY27715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950213.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000805.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27715">
        <property type="protein sequence ID" value="KJY27715"/>
        <property type="gene ID" value="VR44_26985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1559"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8193" checksum="240A66CEBBC6302D" modified="2015-06-24" version="1">MAGTSHGHTPAAWTGVVISFIGFCVAGAFMVIANPVGFWAGMGVVALGGVVGLAMKAAGMGMPKPAHEDLAEVIAAKQLAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0X1</accession>
    <name>A0A0F4J0X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27915">
        <property type="protein sequence ID" value="KJY27915"/>
        <property type="gene ID" value="VR44_26430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1470"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="47793" checksum="64EAE8D5C20D991D" modified="2015-06-24" version="1" fragment="single">PALGPAPARESGGISPLGLFTVLLGAALPLIDFFIVNVALPAIDADLAAGPAMLELVVGGYGVAYSVLLVLGGRLGDMAGRRRLFLIGMAAFGVTSLACGLAPTAWTLVGARVAQGAAAALMLPQVLATIQATTQGPRRARAMSLYGATAGLSMVAGQILGGVLVAADVAGSGWRSVFLVNVPVVLVGLVLAVRAVPETRSDRPASVDVPGTLLLGLTLVTVLLPLTEGRAAGWPLWTWVSLGVSPLAAVSFYLTERRADRLGRTPLVPPSLLNLVSLRRGLVMLLPFSIGFSGFMFAFAVALQQGLRLGPVAAGLALVPLALGFFAASLSGPRLVGRFGSRVVTAGGLVQAVGIGLLLLTVWRGWPDLGIAALAPGMAVAGVGQGLQLPVLMRLMLSDVPADRAGVGSGVMVTTQQSSLALGVATVGSLFLALDASVGMRDALAVTLAVQLGLIVLTVLLSRRLPRAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1J3</accession>
    <name>A0A0F4J1J3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000801">
        <property type="protein sequence ID" value="KJY27739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950190.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000801.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3161"/>
    <dbReference type="EnsemblBacteria" id="KJY27739">
        <property type="protein sequence ID" value="KJY27739"/>
        <property type="gene ID" value="VR44_26855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1530"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16453" checksum="0111C9E58F19E54E" modified="2015-06-24" version="1">MTEPRIFTSAEELRAAIGEPLGPSGWLEVDQKRIDLFADATGDHQWIHVDPERAAAGPFGTTIAHGYLTLSLLPSLVPQIMRVEGMRMGINYGLGKVRFPATVPVGSRLRATAVITEVTEAGGGVQVAATVTVEREGGEKPVCVAESLSRYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1K1</accession>
    <name>A0A0F4J1K1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000800">
        <property type="protein sequence ID" value="KJY27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27749">
        <property type="protein sequence ID" value="KJY27749"/>
        <property type="gene ID" value="VR44_26820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="32323" checksum="4084678A799150A6" modified="2015-06-24" version="1" fragment="single">MTGAAGGGGSPYAARPWLRQLSAAQLAPVAPPASVLDAFRAAVARAPERVALAYFDGRIGYAEADALSGSLAGYLAGRGVRRGDRVAVMLQNTPHFVLAALAAWKAGAVVVPVNPMYKSAETRHVLGDSGAVALVCADAAWEAYLGDAVRGTAVRTVLTARATDFQTRDDPRVFPGPPAAGGTRRAERSPAPVPASGADAAGSPQGSTPDLAPHVPAGPELPAAPGAPVDLLSVARQGHPAPPDPRLRAEDVALLSYTSGTSGTPKGAMNPHGAVTYNAVRQVTGHPIAEGAGYFALAPLFHITGLVCELTACLVNAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1L7</accession>
    <name>A0A0F4J1L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000755">
        <property type="protein sequence ID" value="KJY28175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950017.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000755.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28175">
        <property type="protein sequence ID" value="KJY28175"/>
        <property type="gene ID" value="VR44_25945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1289"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="398" mass="43571" checksum="9B151AE3020E19D1" modified="2015-06-24" version="1">MPVSDIVPLSPDFDADPHSFFAKLRAAGPVHLVSDPNTRLSEPYWLVVGYEEARAALTHPGLRKDWHATDMFPEFERTAANANMLESDPPHHTRLRRLVAREFTARRVEAMRPRVEQITDGLLDAMAARPERSADLIRDLAFPLPMTVICELLGVPDLDRESFREWSNDVVAPKPGTLDNTAQRRLSAYLVDLVAAKAESPGDDLLSALIRTRDEDGDSLSPDELIGMAFLLLVAGHETTVNLISNGVRALLAHPDQLAALRADWDGLLGGAVEEMLRYDGPVQNSTYRYTGEDVEIGGVVIPAGQAVLVSLAGAGRDPERFPEPDVFDIRRAPGGHLAFGHGLHFCIGAPLARMEGRIAVRGLLERFPDLALDPAGGPLEWLPGALMHGVSRLPVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1W1</accession>
    <name>A0A0F4J1W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Alpha-ketoglutarate decarboxylase</fullName>
            <ecNumber evidence="15">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">kgd</name>
        <name evidence="15" type="ORF">VR44_25720</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="15"/>
    <dbReference type="EMBL" id="JZWV01000745">
        <property type="protein sequence ID" value="KJY28282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949975.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000745.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000058_gene2275"/>
    <dbReference type="EnsemblBacteria" id="KJY28282">
        <property type="protein sequence ID" value="KJY28282"/>
        <property type="gene ID" value="VR44_25720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1243"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="14">
        <location>
            <begin position="946"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY28282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1294" mass="140802" checksum="D8B31056DC3E85CA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J343</accession>
    <name>A0A0F4J343_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_24595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949767.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3000"/>
    <dbReference type="EnsemblBacteria" id="KJY28767">
        <property type="protein sequence ID" value="KJY28767"/>
        <property type="gene ID" value="VR44_24595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.914"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="40258" checksum="0D4A9CC02544A633" modified="2015-06-24" version="1">MAYLDHAATTPMLPEAAAAMTAQFAATGNASSLHAAGRRARRTVEEAREALAEALGGRPSEVVFTAGGTEADNLAVKGLYWSRRDADPARTRVLASPVEHHAVLDAVHWLAEHEGAEVEYLPVDHHGRVRPEAFREAVERNPDDIALATVMWANNEIGTVMPVRELAAVAREHGIPLHSDAVQAVGQLDVRFGDSGLAAMTVSGHKIGGPYGIGALLLGRDQTPVPVLHGGGQERHVRSGTLDVPAIAAFAVAAVLAAERRERFAAEVGALRDELIRAVLAAVPDAVLGGDPEDRLPANAHFSFPGCEGDSLLLLLDAQGIECSTGSACTAGVAQPSHVLLATGTDPQLARGTLRFSLGHTSTKEDVAAVAAAIGPAVARARTAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3T4</accession>
    <name>A0A0F4J3T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstB</name>
        <name evidence="5" type="ORF">VR44_25470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene242"/>
    <dbReference type="EnsemblBacteria" id="KJY28378">
        <property type="protein sequence ID" value="KJY28378"/>
        <property type="gene ID" value="VR44_25470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1191"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="28168" checksum="2A78ADD592BF3C7F" modified="2015-06-24" version="1">MAKRIDVSGLSAFYGSHKAIDDISMTVEPRSVTAFIGPSGCGKSTFLRTLNRMHEVTPGGRVEGKVLLDDENLYGSNVDPVAVRRTVGMVFQRPNPFPTMSIFDNVAAGLRLNGKFKKSELTDIVERSLKGANLWNEVKDRLNKPGSGLSGGQQQRLCIARAIAVEPQVLLMDEPCSALDPISTLAIEDLIGELKERFTIVIVTHNMQQAARVSDRTAFFNLAAVGQPGKLIEIDDTDRIFSNPSVQATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Z9</accession>
    <name>A0A0F4J4Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0225 protein VR44_26340</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0225 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000778">
        <property type="protein sequence ID" value="KJY27966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950090.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000778.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27966">
        <property type="protein sequence ID" value="KJY27966"/>
        <property type="gene ID" value="VR44_26340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1423"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00612">
        <property type="entry name" value="UPF0225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023006">
        <property type="entry name" value="UPF0225"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="14575" checksum="329CA2EC8606603A" modified="2015-06-24" version="1">MTSPVLPCPCGLPAAYPACCGRFHSGAQQAPTAELLMRSRFSAFAVGDTAYLLRSWHPSTRPGRLDLDPEQRWERLEILGTARGGIFDTEGSVEFRAHYREGGHTGSLHEHSAFSREGGAWVYVGPLSPVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J564</accession>
    <name>A0A0F4J564_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxic anion resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000688">
        <property type="protein sequence ID" value="KJY28959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28959">
        <property type="protein sequence ID" value="KJY28959"/>
        <property type="gene ID" value="VR44_24045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11242" checksum="84A0EBDE25F67D68" modified="2015-06-24" version="1" fragment="single">MTTPPTSPLTPPPGYGDGAGAGAGGTGSPLVLTAPEPVPAVHREQASGFVPLADGVREEMARRAGEYVGQLSGIDARSPEFAARINDITALGAADMRSAAGQSNRMLERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5S8</accession>
    <name>A0A0F4J5S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000622">
        <property type="protein sequence ID" value="KJY29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949332.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000622.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5175"/>
    <dbReference type="EnsemblBacteria" id="KJY29717">
        <property type="protein sequence ID" value="KJY29717"/>
        <property type="gene ID" value="VR44_22215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.328"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="36670" checksum="5CBE4E09443B1AC6" modified="2015-06-24" version="1">MTTYDDRASLADLTSTAERVRQSVERVIEGKPEVVRLALVVLLAEGHLLIEDVPGVGKTMLAKTLAKSIDCSVQRIQFTPDLLPSDITGVSIYDQQRREFEFKPGAIFAQIVIGDEINRASPKTQSALLESMEERQVTIDGTTYALPSPFMVVATQNPVEMEGTYPLPEAQRDRFMARVSVGYPSPEAELEMLDVHGGISPLDDLTAVAHAHDVVKLIEAVREVYVAAPVKRYVVDLVSATRSHPDLRLGASPRATLHLLRAVKASAALSGRDYVLPDDVQQLAAPVLAHRLLPTAQAQLNRRTSEQVVHDILQRTPVPATHTRGEVPPGAGARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J613</accession>
    <name>A0A0F4J613_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949534.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29274">
        <property type="protein sequence ID" value="KJY29274"/>
        <property type="gene ID" value="VR44_23350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.610"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470757" evidence="2">
        <location>
            <begin position="33"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="24497" checksum="704AD1AC8B6D1412" modified="2015-06-24" version="1">MRGLKGQSLSGRSSLVLTSAGTVVLVGTVLFAAGCSAGGTGLRDGGPARTESVARNSQPNQPTAAASGPAAMGHSPAPGTGTPLKRVDPVALLKADPKVSAEIKRDLKPCTGKEYPVDVSYGKITGSSVVDIVVNVLSCADALGRGSYVYRSDGGKYENVFADEQPPVYAEIDRGDLVVSKPVYGKSDALSYPSGEDVITYRWNGEKFAEQDRVHSEYSNVGDGGGQPAPAVTPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L9</accession>
    <name>A0A0F4J6L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949263.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29860">
        <property type="protein sequence ID" value="KJY29860"/>
        <property type="gene ID" value="VR44_21860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.251"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="13468" checksum="5464150C862A81F2" modified="2015-06-24" version="1">MSLSIRNQIAGTVTAITAGEAMATVKVRLDGGQDITAAITVDAVKELGLAAGSSVRALVKATEVALATGAVEGLSIRNQIPGTVVDVATGPAMASVKVDVNGGGLTAAITADAVDALGLAAGSSVVALIKSTEVSLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Q2</accession>
    <name>A0A0F4J6Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949242.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29895">
        <property type="protein sequence ID" value="KJY29895"/>
        <property type="gene ID" value="VR44_21745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.229"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="27444" checksum="7AD92B8E4F668FD9" modified="2015-06-24" version="1">MPRESPYLQVVASLRARIEAGEWKIGDRLPSRARFAEEYEVGQGVTQRAMEQLIIEGLLEGRAGSGTYVRTPRRRMRMLRTRRRVPGSGNTFRSEAAAHGIAASWDSRTHPQVPAPERIAARLAIEPGAPCVMTRYEFMADGSPAELSESWEPLAITSGTPVVLPEAGEMRGAGVVARMRSIGITVTSVVEVPRPARANQDQANLLGISLGSMITRIERTYIDSDGRPVETADLVIPDSRYEIAYAFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7B2</accession>
    <name>A0A0F4J7B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000577">
        <property type="protein sequence ID" value="KJY30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30272">
        <property type="protein sequence ID" value="KJY30272"/>
        <property type="gene ID" value="VR44_20860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="30662" checksum="A6F3B058AD1CA6B9" modified="2015-06-24" version="1" fragment="single">MCIRDRDRSSRKLTASDDTEVLLTARDAGVDLADVTIAVTASEPAVPGRCTLTLTLREKPKEQAAGAAGTPEPGRVLDTETWRLLPRNAEQLAAALNGRRSQPVGIGTVSFAKENVLTLKAKAAAPLAAGDLVTVGGAAYAVSEAVTTDGTEIRLLLPDPAPSIAADSPVHLVSYAPVLVSHGRPGGHARYGSRYVTAALANKAGTAIGDVADGTAEALGSAQPPSWWSDLPGRALAFAADTTPPALPAGDGHLSSARLADNLTVEAWVKPAAGTTAEDTRRLVHVNTGSAAADSQFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7R1</accession>
    <name>A0A0F4J7R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_20960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30240">
        <property type="protein sequence ID" value="KJY30240"/>
        <property type="gene ID" value="VR44_20960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8922"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26670" checksum="F462A97A950B6483" modified="2015-06-24" version="1">MRLLLPSLTGVGGRPVTLLHAPGDDPGPVAFVISDVPRPDWDEDALKARFEDLRWLEDAARSHHRVVEALAAHTTVLPLRLATLYQDHAAALGVLRTQGQAFATRLARLSGHTEYGVKVYVRPAPPAEAEPPVAGASPGRAYLQARRAQRSAHEDHYRQAGLATERVAAVARRFTADRVGHPAQSGPLTSASPEENVLNDAYLVPDEHAEAFLEALAGAARGLAGVRVEVTGPWAPYSFAAPPPPPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7W4</accession>
    <name>A0A0F4J7W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949261.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29858">
        <property type="protein sequence ID" value="KJY29858"/>
        <property type="gene ID" value="VR44_21850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.249"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16167" checksum="B9FF07B092EC0B5D" modified="2015-06-24" version="1">MASLLLHGDLDHPARLTVADLRRRPQHRARVVFDCATNGPQHHVFEGALLRDVIAGAGPVFDARRRKDRSRYLLAVSGGDGHHTVLSWAELDDDFCGSPVLLATRLDGEDLDGPGSQLVVPTDRCGARYVSAVTHVWFGTLDVPALIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J830</accession>
    <name>A0A0F4J830_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_20615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949029.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30370">
        <property type="protein sequence ID" value="KJY30370"/>
        <property type="gene ID" value="VR44_20615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8838"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29044" checksum="7DA0B459BABDA55B" modified="2015-06-24" version="1" fragment="single">TLCTLVLGVVAEPAIAHLLSPLLDAVGVPSGVTHAISFVIALALATYLHMLFGEMVPKNVALAEPVRTALLLGPPLVAMTHALKPVIFAINTFANTLLRLLRVDAKNEVAATFSDDELARMVKDSSDAGLIDDRASERLHDALELGRRPVADVVLPVDRVVTARQGITAGGLERLSAESGYSRFPVVDGQRRILGYLHVKDALDAEERAEPFPVSALRPIAQVRAETPLDDVLTAMRASRTHLAAVLGADGAMTGLVTMEDVLRELFGKPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J845</accession>
    <name>A0A0F4J845_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsule biosynthesis protein CapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29918">
        <property type="protein sequence ID" value="KJY29918"/>
        <property type="gene ID" value="VR44_21665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.211"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008337">
        <property type="entry name" value="Capsule_biosynth_CapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01758">
        <property type="entry name" value="CAPSULEPROTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04012">
        <property type="entry name" value="poly_gGlu_PgsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="544" mass="59058" checksum="A8B9D27701B60F92" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9A7</accession>
    <name>A0A0F4J9A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000571">
        <property type="protein sequence ID" value="KJY30343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949044.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000571.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1352"/>
    <dbReference type="EnsemblBacteria" id="KJY30343">
        <property type="protein sequence ID" value="KJY30343"/>
        <property type="gene ID" value="VR44_20695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8854"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17976" checksum="8F37FD30FE3CD61C" modified="2015-06-24" version="1">MRIDVPDGQHPIEYVWGDLVPGIGMAAANFSLSVYAHTTLGLREFEAARLRIAQINGCVFCLDWRTDRDGEKVEEGFADAVTEWRTTPAFDDRTRLAAEYAERYALDHHNLDEEFWERMTAHYSQVEIVELSMSIGSWLAFGRLNHVLGLDSVCVLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9M5</accession>
    <name>A0A0F4J9M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000528">
        <property type="protein sequence ID" value="KJY30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948785.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000528.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30905">
        <property type="protein sequence ID" value="KJY30905"/>
        <property type="gene ID" value="VR44_19265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8459"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="12765" checksum="66BE2888161E3412" modified="2015-06-24" version="1">MGSNGDERPVHIGNISNTAFSIGGSNNTNTVHNGAPDGRPPTAEELLRAVHELRVELVRIPRSSGRGELDAELEDAAAELEQAGEIRPGLPARLRGALERWAPLVETVSAATALGGLLASLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9N0</accession>
    <name>A0A0F4J9N0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">VR44_19295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000528">
        <property type="protein sequence ID" value="KJY30910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948790.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000528.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5426"/>
    <dbReference type="EnsemblBacteria" id="KJY30910">
        <property type="protein sequence ID" value="KJY30910"/>
        <property type="gene ID" value="VR44_19295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8465"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="55682" checksum="46876C40C579A522" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAF9</accession>
    <name>A0A0F4JAF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-hydroxychromene-2-carboxylate isomerase</fullName>
            <ecNumber evidence="1">5.99.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate</text>
            <dbReference type="Rhea" id="RHEA:27401"/>
            <dbReference type="ChEBI" id="CHEBI:59350"/>
            <dbReference type="ChEBI" id="CHEBI:59353"/>
            <dbReference type="EC" id="5.99.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. NadH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.99.1.4" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948663.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31180">
        <property type="protein sequence ID" value="KJY31180"/>
        <property type="gene ID" value="VR44_18635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8336"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018845">
        <property type="term" value="F:2-hydroxychromene-2-carboxylate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="4">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="27746" checksum="0CF7AFE9FFE6D040" modified="2015-06-24" version="1">MSEAAPSPGARRQAPPRFYFSLRSPYSWLAHQELLARHPDVVERLEWRPFWEPDEESARALEAAGGRFPYVAMSREKHLYILQDVRRLTRERGLEPTWPVDREPCWEVPHLAWLVAQDAGRGPEFVGRVYRARWQEGRDICDPSVIGELGAELGLPAERLAGAARDPELRARGVSALLDVWRDGVFGVPFLIDGHDKFWGTDRISDFARSVRGRATRDGNRKCAKAGSPNAPADTVARSADGGHAGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAG0</accession>
    <name>A0A0F4JAG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M6 family metalloprotease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949213.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000603.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29936">
        <property type="protein sequence ID" value="KJY29936"/>
        <property type="gene ID" value="VR44_21605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.198"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470760" evidence="2">
        <location>
            <begin position="32"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="425" mass="45295" checksum="D551B1F4AD4F4B4A" modified="2015-06-24" version="1">MPQTRHRIRRPCRTGAFIGLTALALGVTATASGGVPGRSHTTSGPKATSAESALAPCRISATMGVQLSEGLPTAPGYSRSTGEIRALNLMIDFPDAKGEGSAMDRLAEFFPQTSEWFRTSSYGRLTYRAEAPIRNWLRMPMPFAAYGIERGSAYEPGYRQLVEHIARAADPEVDFSRYDLINILVTPNAGPSALDTVLSVTFSGNAEAPMADGVPLANTSFVYSRQDDGSGSYRETGYRVLPHENGHVFGLPDLYTSDGGGTVGHWDIMSEDWGANNDLLGWHKWKLGWLDGSQISCASKPGASEHLLTPLAVAGGTKLAFVPLSESAGYAIEVRTRAGNDEAVCKPGVLIYRVDSEVDTGRGPVTVSDSASGSGGCTRRPNVHAELSDAPFRPGETFTDDKARISISVVAALPGGGFRVRVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAH1</accession>
    <name>A0A0F4JAH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949190.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29946">
        <property type="protein sequence ID" value="KJY29946"/>
        <property type="gene ID" value="VR44_21485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.175"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="29463" checksum="FF863F9C592DB98D" modified="2015-06-24" version="1">MYVSVATEPGGSAPNEDWVGGTPSLALVLDGLSTAGLGTGCRHGVPWYVAQLGSQLVAALATGDRPLADGLAEALERVGRLHPECDLQNPGTPSATVAILRERPGHFDHLVLADSPIVLEGADGITVLTDLRVDEVCQDLRAETEQFATGTPEHRASVARLVAAQRKIRNTPEGYWVAAASPDAASHALTGTVAAADVRSAAVMSDGVSRLVTEYQMATWEGLLAQLRTSGPAALIRSIREVEATDPHGQRWPRYKAGDDAAVAFCSFAQGPQDAALPDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBW3</accession>
    <name>A0A0F4JBW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Wyosine base formation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000501">
        <property type="protein sequence ID" value="KJY31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31299">
        <property type="protein sequence ID" value="KJY31299"/>
        <property type="gene ID" value="VR44_18440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8283"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21352" checksum="CB7D5CDE9BCD0E49" modified="2015-06-24" version="1" fragment="single">MPEPSVVAVFADLREEGRELDSLVGGLAGSEWARPTPAEGWSVAHQIAHLHWTDRAALLALTDAEGFAREVEAALEAPDSFVDEGAEEGARLAPAELLARWRAGRRELDRALAAASPDARFPWYGPPMKAASMASARLMETWAHGQDVADTLGVRRVPTARLRHVARIGVRARDYAYAVRGLAAPAGEFRVCLLYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC53</accession>
    <name>A0A0F4JC53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042810711.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31917">
        <property type="protein sequence ID" value="KJY31917"/>
        <property type="gene ID" value="VR44_17110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7954"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470916" evidence="1">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22241" checksum="F5740AE256E3D5F4" modified="2015-06-24" version="1">MSSQVRGGTRWKRFALVMVPSIAATAAVGVGLAQGALAASFSVSGQDFKVSADQLVGDNLIQYGSVAEGATLGSKDISKHPVTISGFSRAEITNMCQSLVTPVPGLGAITLQLHTGNKGKPAVAENIYLDVAELDADAKFDQLDIGVAVGDGSHVTKPVPGTVADGGLFSQRAKKATLTNVRQKAWATTAGTFTLPDLKLRLLSGNQPCYQDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD31</accession>
    <name>A0A0F4JD31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000478">
        <property type="protein sequence ID" value="KJY31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948485.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000478.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31643">
        <property type="protein sequence ID" value="KJY31643"/>
        <property type="gene ID" value="VR44_17705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8037"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="33952" checksum="81E7C29B5AF2943A" modified="2015-06-24" version="1">MTAGPNDVMPGAIRPGWAPAHAWRWFLLRSAKHIPRATRDQPEWKSLGASFFAILQAVGQAANEDGTNAFLGTDTLMAIGRCSKETVQKVLVAAEAVCLIRKTANARGGRCPKPATYACTLPLGADTETGCGIAWERALAVLSSSEYDRRLRHKRAKSSGQHVTPADRRRMQALEASRDALVPADEVIEGASRDEGRQRHVTDQKASHDAPTRLHQALHHEMAEVVSQPQVDGALASALRGQPPTTATAAPDGHEDSRSSTPAAANYARHLAACDRCPREMWCPQGSRLRKYLVAEQHHKRARHLPSAPDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDS9</accession>
    <name>A0A0F4JDS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948698.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000515.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4121"/>
    <dbReference type="EnsemblBacteria" id="KJY31131">
        <property type="protein sequence ID" value="KJY31131"/>
        <property type="gene ID" value="VR44_18815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8374"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20403" checksum="7E54F6532C20D4D5" modified="2015-06-24" version="1">MSGRNTALTPPADAVAPVRHPDAPAPGELLGTHYEHCFGCGGGQPHGLHLEARAGEGVRVTAEFTVRPAHQGAPGLAHGGVLATALDDTLGSLNWLLRVIAVTGRLETDFVRPVPVGTVLHLEAEVTAVAGRKIYSTAVGRIGGPEGPVAVRADALFIEVKVDHFIENGRPEEIRAAMSDPDQVRRARAFEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE16</accession>
    <name>A0A0F4JE16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_16990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948351.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31983">
        <property type="protein sequence ID" value="KJY31983"/>
        <property type="gene ID" value="VR44_16990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7927"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21003" checksum="2C689A021F4344E5" modified="2015-06-24" version="1">MTRLILATRNAGKVTELRAILSDAGLPHELVGADAYPEVPDVKETGVTFAENALLKAHALAQATGYPAIADDSGLCVDVLNGAPGIFSARWAGAHGDDRANLELLLSQLGDIPDEHRGAHFFCAAALALPDGTERVVEGRLLGTLRHSPVGGGGFGYDPILQPTGETRTCAELTPAEKNAISHRGQAFRALIPVLRELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JED7</accession>
    <name>A0A0F4JED7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000435">
        <property type="protein sequence ID" value="KJY32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948259.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000435.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32164">
        <property type="protein sequence ID" value="KJY32164"/>
        <property type="gene ID" value="VR44_16495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7698"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470645" evidence="2">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="34874" checksum="E18EDC834CF68691" modified="2015-06-24" version="1">MTGVAVAVLAVSLAGCGSPKGEKDDKGKKTPTATNSPAAAAASPSPEGKVRMPTGPAPTLTKARDTAVGPISVTRLAGPKSGVTGQVWVWLPPEYNDPKYAKTGFPVLTLFAGGQSNGYNTWAGSELPIQEEDVRLAKAGKAHPFIMVMPVQNFTSDEKRALDCSDIPGQPKMATWMTQDIPDWVRANFRTLKGRDSWGVMGASTGGFCSAKLALQYPDVYKAAVPIDGYFIPDSRLWQGHEAEKAANNPDLLVTQGKADVKMLVTAGGADAFEKGVVKSWMAKAAPPVAIEYYEQPGGKHLTSDFRKMIPDALQWFTKNLEGPAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEX1</accession>
    <name>A0A0F4JEX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000489">
        <property type="protein sequence ID" value="KJY31501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948545.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000489.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31501">
        <property type="protein sequence ID" value="KJY31501"/>
        <property type="gene ID" value="VR44_18020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8150"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="22389" checksum="A9B75BD378130A3F" modified="2015-06-24" version="1">MQTFATATPVSAVLDIPAGRVRLIAADRADATVEVRPSDPSKSRDVKAAELIEVAYADGVLRVVAAQAKNRITGNSGFVEVTVQLPAGSHVEAKVAAAEVLGTGRLGDVVLDAAQAQVKLDETASARVTVQSGDIALGRLGGPAEINTQKGEITITEATAGVVTLTTQHGNITVGAARGVAATLDAGTGFGRIDNALQSADGTPLTIHATTAFGDITARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF95</accession>
    <name>A0A0F4JF95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000413">
        <property type="protein sequence ID" value="KJY32423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948170.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000413.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32423">
        <property type="protein sequence ID" value="KJY32423"/>
        <property type="gene ID" value="VR44_16010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7622"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22360" checksum="E173A566459F2999" modified="2015-06-24" version="1">MPLPRFDRLPAERREHILGVARRHFAEHGAEGASYNKIIEAAGVSKTAAYHYFDGREDLLTAVLDGVLDRLLHALGPWGPARDEEDFGARFAAGSAGLAAHLRDHPEDLALADAAIGRSDGTPWLDWFDALVTDGRRLGMIRTDVDHALMVSATAAVIRAADAWAVALMTSGSLEGLPQGDPPHQLWTLLRGLWGAAAAAPGQEPNGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFE7</accession>
    <name>A0A0F4JFE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947912.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33062">
        <property type="protein sequence ID" value="KJY33062"/>
        <property type="gene ID" value="VR44_14585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7243"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="16"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15063" checksum="9572D48D6BFD16F7" modified="2015-06-24" version="1">MIGVIDTDGECAEWAFPAEPGAVRTARHAVRGALRTWGLDAVGDVTVLLVSELVTNSLRYASGPIGVRLERRNPAVPGLTGGPALLVEVSDPLPDPPREKVAEPDDEGGRGLHLVAVSARRWGTRHGKSGKTVWFELALPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFL1</accession>
    <name>A0A0F4JFL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_15785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32543">
        <property type="protein sequence ID" value="KJY32543"/>
        <property type="gene ID" value="VR44_15785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7564"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="32487" checksum="3FBB0374CC65BDD4" modified="2015-06-24" version="1">MRKRARGLRTWAVGLRTRAETRVPMITHLMEHLISVNVLDSATRLAAQTFLTAVPLLFVLSSIAPEGLREEYASSLQHLFGLSGSAQAELDKVLKQTGAPSDELQQTIGTVGVLMVLISATACSRAMQRLCERAWSLPKSGARVAAWRWIAWIGAWLVMIGLQGSLLTAFGHSEWLGVLLLFLAEVAMWWWTQHLLLTARVPWLPLLPGAVMTGTALSVLSTTAPLYLPRVLNRSLNTYGTLGAVFTLLSWLITLCAVVALCVTAGAVVAREPWAARRLGTPAPSGPAPSRTGAGQRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHI0</accession>
    <name>A0A0F4JHI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000367">
        <property type="protein sequence ID" value="KJY33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947850.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000367.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33269">
        <property type="protein sequence ID" value="KJY33269"/>
        <property type="gene ID" value="VR44_14230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="30135" checksum="E3717B0853E4E3B2" modified="2015-06-24" version="1" fragment="single">MTDQVTRIHVGASGPLPAVAGGAGHDAYDVLVGRQLLGELGGLIGTKAQRVAVIHPEALAETGEALRADLAEQGYEAIAIQVPNAEEAKTVEVAAYCWKALGQSNFTRTDVIVGVGGGATTDLAGFVAASWLRGVRWIAVPTTVLAMVDAAVGGKTGINTAEGKNLVGAFHPPAGVLCDLAALDSLPVNDYVSGLAEIIKAGFIADPVILDLIEEDPAAARTPAGPHTAELIVRSIQVKADVVSSDLKESGLREILNYGHTLAHAIEKNERYKWRHGAAVSVGMVFAAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHI5</accession>
    <name>A0A0F4JHI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">VR44_14205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000366">
        <property type="protein sequence ID" value="KJY33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813990.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000366.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3359"/>
    <dbReference type="EnsemblBacteria" id="KJY33274">
        <property type="protein sequence ID" value="KJY33274"/>
        <property type="gene ID" value="VR44_14205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7188"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20688" checksum="1208599FF6614C9D" modified="2015-06-24" version="1">MASTNDLKNGMVLKLDGDQLWSVVEFQHVKPGKGPAFVRTKLKHVLSGKVVDKTFNAGTKVDTATIDRRDMQFSYMDGDYFVFMDMQTYDQLMVDRKAVGDAANFLIEGFTASVAQHEGEVLYVELPAAVELTIEHTDPGVQGDRSTGGTKPAKLETGHEIQVPLFVTTGEKIKVDTRTSAYLGRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHQ6</accession>
    <name>A0A0F4JHQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947622.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33887">
        <property type="protein sequence ID" value="KJY33887"/>
        <property type="gene ID" value="VR44_13005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6719"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470743" evidence="1">
        <location>
            <begin position="28"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="30403" checksum="49A95B2FC2693419" modified="2015-06-24" version="1">MKKSLVAALATATLAITLAAPATPATAASAFCNQTTPSTSLAAYNKDTGAVGTGTLSAGHWTFGSNINVPDGYTHGVASRDSLLFYNADTGAGESGTFRNGRYTRVQTYNNFSTGWTHVVASGDSALFYNADNGQGGTGTLRNGRYHHVRSYDNFSTGWDSIAASCDTAVFTKSGEVGYGTLTGGVYQHVGVRDTEDLGTLVATKDTVLALENTGSQLKYRTARATNGKVGGFRDIGTSGVWDEEGRTSDSLFFYKTDGTAWTSTLSGNNYANVGSLANVSSDWSFLAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI74</accession>
    <name>A0A0F4JI74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947768.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33499">
        <property type="protein sequence ID" value="KJY33499"/>
        <property type="gene ID" value="VR44_13810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7041"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11839" checksum="AE0FD2BE7D03E87D" modified="2015-06-24" version="1">MAREEKVMLTAREVSYLWPGVRPHSVYVNALAYGVRMATDSWPTTTGYASKVSYNADDVRRVAPQVAAKPLKGPSRVPCCLLLIVLIVGPFVWLAIYIVRGSGWSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ62</accession>
    <name>A0A0F4JJ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33818">
        <property type="protein sequence ID" value="KJY33818"/>
        <property type="gene ID" value="VR44_13205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6859"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="13137" checksum="D91E997B35F09820" modified="2015-06-24" version="1" fragment="single">VVDLVRECGARDRTYYCAGPNTMLAVRAADPDAEIALTWTTLSPPRRVLIDAVSPRWLNYRFGLVSRELTDALHRDGLLVSAWTADTKRSMRALLRAGVDAVTTNRLDALAAVRAELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJX8</accession>
    <name>A0A0F4JJX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34119">
        <property type="protein sequence ID" value="KJY34119"/>
        <property type="gene ID" value="VR44_12530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6567"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="172"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="36967" checksum="6420F814F06CA9E5" modified="2015-06-24" version="1">MTMQKDAGVSVEAMIEDLRTLVEVESPSRDVESLAASAKAVAGIIEHRLGGHAVLVESEAGPHVHWSGGGEPKVLLLGHHDTVFPLGTLDRRPFTVADGRVTGPGVFDMLGGIVQAVHGLATLADRSGVEILITADEEVGSRSSRALLEERALACGAVLVLEGAADGGGLKTGRKGCGAFQVSIAGRASHAGLEPTAGINALVEAAHQVLDITAIGRPEAGTTVTPTVASAGTLENVVPAEATVVVDVRVESAEERARVESAFAALAPHLPGARISVEGSITRPPMPESAAAGLFAVARRLLPGIEGRAVGGGSDGNFTAALGVPTLDGLGAVGGGAHADHEYVLIEAMAERAGLVAGLVATLQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL63</accession>
    <name>A0A0F4JL63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000280">
        <property type="protein sequence ID" value="KJY34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947367.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000280.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34559">
        <property type="protein sequence ID" value="KJY34559"/>
        <property type="gene ID" value="VR44_11650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="36783" checksum="C7F1FCDC11ED2B1E" modified="2015-06-24" version="1">MFVAWRDLRFARGRFALMGSVVLLITLLVGLLSGLTSGLARENISAITGLPASRLAFAVPPGDQKVSFTNSQLPESAWRTWRGRPGVKAADPLGIRTTNALAGERTAAVSVFGVEPAGRLAPAGTGLGRGRAVLSEKAAKELGGLRAGDRFKAGPLELTVAAVSGTAAYSHTPVVWADLEDWQRIGGPGSSPETSATVLALDGVDVDWAAGDKAAGTRSQTVDEALGAIGSYQAENGSLQLMRGFLFAISALVIGAFFTVWTIQRSGDVAVLKALGASTPYLLKDALGQAVVMLAIGTGTGTLLASGIGALISGGDVPFVLDAATVLAPAGIMIVLGALGAALSIRRITAVDPLTALGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL89</accession>
    <name>A0A0F4JL89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947212.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35112">
        <property type="protein sequence ID" value="KJY35112"/>
        <property type="gene ID" value="VR44_10805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6011"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="517" mass="53299" checksum="F2C0D8CC1E6F071F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLJ2</accession>
    <name>A0A0F4JLJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000275">
        <property type="protein sequence ID" value="KJY34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34633">
        <property type="protein sequence ID" value="KJY34633"/>
        <property type="gene ID" value="VR44_11585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6228"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="165"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="36902" checksum="F7CB3D195D050B22" modified="2015-06-24" version="1">MLLAPVVLGSFAPSSAASQPRELLVPSAAYPTVQSAVDAAHPGDRIALRPGVFREQVRIGKDLTITGAGAGKSTILAPEHLVTGPDGLNSIVFLDNRASVRMSRLTVSGPGSGTCETGALGAGIRVLGGAHLDLSHAEVSHIKDTPMAPCFRSANSVLIGDLPTGTGSADIRDSRITDYQGSGIVVLNASSKATVLRNTVTGQKRISTDGIEFIDATGRIEQNTVSDNACREPDPGCGTDFFTEIQHAGILANTGNVVTGNRLVGNQLGIYAFGTVDTSRNTIVDSDYFGIAFQDGTFTAFKDSIRGGAGGVAVIASAVDTTARLDQVRITKVSGDRIRTFECCGFTAKVTPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLX5</accession>
    <name>A0A0F4JLX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000260">
        <property type="protein sequence ID" value="KJY34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947290.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000260.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34829">
        <property type="protein sequence ID" value="KJY34829"/>
        <property type="gene ID" value="VR44_11230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6256"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045676">
        <property type="entry name" value="DUF6194"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19694">
        <property type="entry name" value="DUF6194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="17097" checksum="F9D4A4CE824688EB" modified="2015-06-24" version="1">MTSEEIISFVNTLDGVLILRPAPGDGTPEISWGDTFFYYAPDGVTPTASQPFATVVTKDYPDDESSRLDRPGAFRVNIAAGKDAFIRWTGHAPREPVSAEVDPSAADTVIAHPVYGSLGWLAVVNPGERTQAATRELLRTAHHLARSRHERRTEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMH7</accession>
    <name>A0A0F4JMH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000311">
        <property type="protein sequence ID" value="KJY34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947529.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000311.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34151">
        <property type="protein sequence ID" value="KJY34151"/>
        <property type="gene ID" value="VR44_12500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6560"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="44819" checksum="81D389B46F349D9B" modified="2015-06-24" version="1">MGIAVAVAALGGAAATAYTFTFGGAPAQGEAKLAATQSAADAAAAAKGAEQPWDGKVKVLGDGSTSYTGPQPNQLKPEKLKPGEKPPQFVVFSWDGALEGDDHLFSHFRQVAKDSKAHMTFFLTGIYLLPDDKKALYHPPQHPQGAAAISYPTVPHVKSTLGQLRGAWTDGNEIGSHFNGHFCGPKGGGDWSPDEWKSEIDQTYAFIKNWKTNTGFTKEAPLPFDPDREVVGGRAPCLEGQKNLLTAIKPYGWRYDASSSGDFQLWPSKQNGIWNFPLQLVPLQGKELQVLSMDFNFLYNQSGDSTKGDPAKYPAWEAQTRGSYLNGFNRVYNGSRAPMFIGNHFEDWNGGIYMQAVEDVMRDVCPRQDVRCVSFKELSDWLDAQDPKVLAQLRMLDPAQAPDWNTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMJ4</accession>
    <name>A0A0F4JMJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947516.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34171">
        <property type="protein sequence ID" value="KJY34171"/>
        <property type="gene ID" value="VR44_12455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6551"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="17528" checksum="48ADD70160FE6F30" modified="2015-06-24" version="1">MNGSEAWGDEVYQPSAETERGEAQPDMENALGEPDLDQTLDSGYSPPDRPLAAGRHGTTAGEQRAGESLDQRLAQEQPEADGADAGLGSEEAPGDDLGGEGGGGPGGSGDMTGDPHGDGSTAGRERAGRMASAEEGPPVRHLSVLARDTGVDGGAASAEEAAVHVVEEEPDGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMR1</accession>
    <name>A0A0F4JMR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_12315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947493.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34241">
        <property type="protein sequence ID" value="KJY34241"/>
        <property type="gene ID" value="VR44_12315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6448"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="24992" checksum="5634553D6ADFC10A" modified="2015-06-24" version="1">MNTAVVLVADDDAAIRRSLERGLRLSGFTLAEDGPGALAQAGSRSPDVLVLDVSMPGLTGTEVCRSLRARGDETPVLMLSALDELADRVAGLQAGADDYLVKPFALEELVLRLHALLRRSPARGGRDVLRAGPLELDQATRQVHHGGAEVHLTRREFELLAALVRNAGIVLTRDQLLDRVWGYDFEVRTDAVDTFVSYLRRKLEEGGRPRLIHTVRGVGFVLRAPGAGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMS6</accession>
    <name>A0A0F4JMS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000245">
        <property type="protein sequence ID" value="KJY35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947233.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000245.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35053">
        <property type="protein sequence ID" value="KJY35053"/>
        <property type="gene ID" value="VR44_10925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6065"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="32782" checksum="2F0C8361527A5CCA" modified="2015-06-24" version="1">MSASGGTKAIVAALAANLAIAVAKFVAFLFSGSSSMLAESVHSVADSGNQGLLLLGGKKAKREATPQHPFGYGRERYIYAFLVSIVLFTVGGLFAIYEGYEKIHDPHPIDAWYWPVGVLVFAIVAEGFSFRTAIKESNETRGSQSWTQFIRSAKAPELPVVLLEDFGALVGLVLALFGVGLALITGDGVWDGVGTVCIGVLLLVIAVVLALETKSLLLGESAGTAEVEKIKAALVDGDTVTGVIHMRTLHLGPEELLVAAKIAVQHDDTATEVANAINAAEARIRASVPIARVIYLEPDIYNPEAAKADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPE3</accession>
    <name>A0A0F4JPE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35714">
        <property type="protein sequence ID" value="KJY35714"/>
        <property type="gene ID" value="VR44_09400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5208"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="59"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26749" checksum="4E6C13452AC6F59D" modified="2015-06-24" version="1">MWGVTTLVPAGEDHPLPSHGNASGSSAAPGDGKRGGGASATPSSSVPDGIAHASEAGGNAVDITIDDGPDPRWTPQVLDVLAKYDVKAVFCMIGPQAKAHPDLVKQVVAAGHRLCDHTMDHDTAMDKKPVAYQEAQILDAKKLIEEAAGGGARVEYYRRVEYYRAPGGAFTPDSRRIAAAAGMRPLGWNVDTKDFGRPGTAAIVANVKREIGNGPTVLFHDGGGDRRQTVAALDQVLGWLKDEGRPTGFPVRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQD9</accession>
    <name>A0A0F4JQD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36059">
        <property type="protein sequence ID" value="KJY36059"/>
        <property type="gene ID" value="VR44_08680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4980"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="15802" checksum="F13AD751351B8385" modified="2015-06-24" version="1">METQHSAAKIVVGVDGSPSSQAALRWAMRYAGLVGGKVEAVTAWEVPGEASWSAPAVDATFDEEDAQRRLVDEVRTVLGEEGASLVRERLVHGHPVEVLVDAADGAEMLVVGSRGRGGFRRALLGSVSQQVALHAPCPVTIVRQDVHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRJ8</accession>
    <name>A0A0F4JRJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000163">
        <property type="protein sequence ID" value="KJY36398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36398">
        <property type="protein sequence ID" value="KJY36398"/>
        <property type="gene ID" value="VR44_08105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471180" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6666" checksum="3086C4D34B6C781D" modified="2015-06-24" version="1" fragment="single">MARTRASRPRRTVRRPRASAAGLAAGVLLTGLFGAPVHAYTAATPSPAPPVGSVPGNARDARYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRW9</accession>
    <name>A0A0F4JRW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37112">
        <property type="protein sequence ID" value="KJY37112"/>
        <property type="gene ID" value="VR44_06530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10502" checksum="60A7F5B4C43EE686" modified="2015-06-24" version="1">MKIGEGREQERTETESVQELPTQGIPLRELRKRLRLTQAEADERAGHGKGWAERIERQELGKLGTGTLAAYLAALGYRLELVAVREGERFRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTP6</accession>
    <name>A0A0F4JTP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946162.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37737">
        <property type="protein sequence ID" value="KJY37737"/>
        <property type="gene ID" value="VR44_05180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1351"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="36013" checksum="7A21E9F67749FA98" modified="2015-06-24" version="1">MITSEPVGEWFWEPAPVSDAAENGTARALGLLSDARNVLASLGLVAEGGTVSVVLSDRRAMASPLFAVRDVPVEAGDALGAGAAAAAAEAAAVGLLPDRLLTLSLKLPGEWTESGARRRAEKLFTVRVDVWGEGGVVLVLSTYADAWLTQDLRERPQPEVAAENAPRLTAALKRISESTGSEIDPGDATRHARPTAEGFADLLAEGAEYDDSWSTFEVPARWKRLMKLVPGDSAGQDYESSTEHPVRYAHVRQGEQVLGYLWAAVGDEAAGYEPRTAAGDAAFEAGVPWLLKLRDLRLRGFGPLEALNELLGGSADGSAVESVVHEAASLDALEELSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU90</accession>
    <name>A0A0F4JU90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">VR44_05720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000106">
        <property type="protein sequence ID" value="KJY37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042809372.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000106.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2531"/>
    <dbReference type="EnsemblBacteria" id="KJY37404">
        <property type="protein sequence ID" value="KJY37404"/>
        <property type="gene ID" value="VR44_05720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1959"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34317" checksum="4C7BD6FA842154C1" modified="2015-06-24" version="1">MSDRSPEPTAPHRAGFACFVGRPNAGKSTLTNALVGTKVAITSNRPQTTRHTVRGIVHRPDAQLVLVDTPGLHKPRTLLGERLNDVVRTTWAEVDVIGFCLPADQKLGPGDKFIAKELAGIKKTPKIAIVTKTDLVESKQLAEQLIAIQQLGAELGIEWAEIVPVSAVGDNQVQLLADLIAPMLPESPPLYPEGDLTDEPEMVMVAELIREAALEGVRDELPHSIAVVVEEMIPRENRPADRPLLDIHANVYIERPSQKGIIIGPKGSRLKEVGMKSRKHIEALLGTPVFLDLHVKVAKDWQRDPKQLRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUF7</accession>
    <name>A0A0F4JUF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">VR44_04450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946032.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000060_gene2713"/>
    <dbReference type="EnsemblBacteria" id="KJY37977">
        <property type="protein sequence ID" value="KJY37977"/>
        <property type="gene ID" value="VR44_04450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.697"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY37977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="31481" checksum="0EC03E818F250FED" modified="2015-06-24" version="1">MAPISTPQTPFGRVLTAMITPFTADGALDLDGAQRLAVHLVDAGNDGLIINGTTGESPTTTDAEKNDLVRAVLEAVGDRAHVVAGIGTNDTRHTLELARQAERTGAHGLLAVTPYYSKPPQEGLFQHFTAIADATGLPVMLYDIPGRSGVPINTETLVRLAEHPRIVANKDAKGDLGRASWAIAQSGLAWYSGDDMLNLPLLSVGAAGFVSVVSHVVTPDLREMLEAHLGGDVQKATEIHQKLLPVFTGMFRTQGVMTTKAALNLQGLPAGPLRLPLIGLTDEETAQLKLDLAAGGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUI9</accession>
    <name>A0A0F4JUI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37850">
        <property type="protein sequence ID" value="KJY37850"/>
        <property type="gene ID" value="VR44_04800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1040"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24133" checksum="1124D48782BF2BDE" modified="2015-06-24" version="1">MFVPSFYREPDGSWMVDLVRGNPMALAVSNGAPEDGPFATHLPVIFDPGASADRPGGLLPGSGLLGHMNRANPHWAALETGAVLLLTFTGPHSYVSPTVYGKTPAAPTWNFTSVHVRGVVEKIESIEETLEVVQSTVRAYEGAFGNGWDMTGSLDYFRKIVPDVGAFRFTVTGAEGMFKLSQEQPDEVRERVRESFGQSACAYKRETAGLMGRLPSGSPEAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVV1</accession>
    <name>A0A0F4JVV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis protein MoeE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000063">
        <property type="protein sequence ID" value="KJY38482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945865.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5739"/>
    <dbReference type="EnsemblBacteria" id="KJY38482">
        <property type="protein sequence ID" value="KJY38482"/>
        <property type="gene ID" value="VR44_03500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8237"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16614" checksum="B30D10DE2614878A" modified="2015-06-24" version="1">MAPHFDHPGEQAAQDPIRLLAIRETPLSIDEVFKAVGDDATGGTTLFVGTVRNHDGGADVDSLGYSCHPTAEAEMRRIAERVVEKYPVRALAAVHRIGDLSVGDLAVVVAVSCPHRGEAFEACRMLIDDLKHEVPIWKHQTFSDGTEEWVGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW02</accession>
    <name>A0A0F4JW02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">VR44_06440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946401.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37156">
        <property type="protein sequence ID" value="KJY37156"/>
        <property type="gene ID" value="VR44_06440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3200"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14551" checksum="7730902E0BDFBD06" modified="2015-06-24" version="1">MIVIDASAVVDLLVSTGKISTVVAKRIDVEDTVFAPVHFDYEVAKVIRRLFLSQKIDRVRADAAMDALPLLPIARFELLDLLPRVWSLRDNAFTGDALYLALAEKFGCPLVTTDSKLSNTPGHHAVIEYLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW55</accession>
    <name>A0A0F4JW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945910.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38400">
        <property type="protein sequence ID" value="KJY38400"/>
        <property type="gene ID" value="VR44_03765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8656"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470944" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16641" checksum="9D912246F7AE980C" modified="2015-06-24" version="1">MSSHRRPLRLLALPALSAGLALAGCAPGASEVRVTPPPAPPADVAGLCAALHKELPETVSGLDRTATEPESDLTAAWGGPAIVLRCGIPKPAKMADPKADGVEVNGVGWLVERPADGGLKFTTGSRLAYTEVWIDKEHATDASMLVGLSAAVAKTVPAGISSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWF6</accession>
    <name>A0A0F4JWF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946317.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37321">
        <property type="protein sequence ID" value="KJY37321"/>
        <property type="gene ID" value="VR44_05995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2413"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20808" checksum="8D260EC13529ADC1" modified="2015-06-24" version="1">MTAVPTTDPRPLTGEPLALDLVNTRWTPEGVPTDLFAGAFGLSRLEGLRLWLESTGLAARFRADKSTLVHLLTAREALARAVADPEDASARELVDAVLEHGRIRATLTAEGPGERAEFDDPSWGPAWMAARDYLDLLGSAPDRIRKCASDTCVLHFHDTSRNGTRRWCSMAVCGNRAKASRHYARTRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXL3</accession>
    <name>A0A0F4JXL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946159.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37731">
        <property type="protein sequence ID" value="KJY37731"/>
        <property type="gene ID" value="VR44_05140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1343"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="31566" checksum="0AE4B4AE8A73C3A0" modified="2015-06-24" version="1">MTTVTRDDLSGYLRRLGVADPGAPSVEGLYALARAHVERVPFENLDIQLGRPPGIDPALSVRRIAAGRGGYCFHLNGAFAALLEGLGYEVTRHLGGMHADPRALDAGGDHLALTVRIGEQELFVDVGMGDGPYEPLPLRAGAYEQGFAYRLEPHAVTWDGGGSQGGGWSLLRDGVPTPRMNFRSAAAAMADFEPAHRFLSTAEDSPFRPSLVMLRRSADGIDRLHGRMLIRTAVDGTRTVRELTGADELFGAVTEVFGRALDDVTAEDRAALWDRVTRAHEAWLAARAAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ04</accession>
    <name>A0A0F4JZ04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945713.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38928">
        <property type="protein sequence ID" value="KJY38928"/>
        <property type="gene ID" value="VR44_02670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6840"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="25782" checksum="3AC160EAB3820391" modified="2015-06-24" version="1">MTRVLVVEDDPQLVRALRINLQARKFDVDEAGDGGSALRLATARRPDVIVLDLGLPDMDGIEVIRGVRGWSRVPIVVLSARHTSEDKIRALDAGADDYVTKPFSMDELLARLRAASRRQAEPAHTADDITVVETDGFTIDLLAKKVRRGDRTVRLTPTEWHLLEILVTHPGHLITQNRLLLEVWGPTYSENTNYLRVYMAQLRRKLEADPSHPRYLITEPGMGYRFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZG2</accession>
    <name>A0A0F4JZG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945587.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39219">
        <property type="protein sequence ID" value="KJY39219"/>
        <property type="gene ID" value="VR44_02015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5809"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20052" checksum="F74F3F0706D89EF7" modified="2015-06-24" version="1">MKVFSSTFDDQGRLPGRVPHRRAGRAGHDAPPVNRNPHVAWSDVPEGTRSLVLVAVDVGIPTGFDEPHRSGRAVPADLPPQEFPHWVLVDIDPRIGEIAEGALGEGDHRGFFAGDPEPAGGRSGTDGPCPPGDDGLVHRCVFLLYATDLERFPLDGTFSAADVLEAIDRHVLGEASFTGHYALDPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZG7</accession>
    <name>A0A0F4JZG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945490.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39500">
        <property type="protein sequence ID" value="KJY39500"/>
        <property type="gene ID" value="VR44_01485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4730"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8167" checksum="C2AD6383210DAFAA" modified="2015-06-24" version="1">MPYVNVRITREGATAAQKAEIIAGVTDLLVKVLDKDPATTFVVIDEVPLENWGVGGVPTEEYRRRTRPREASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZP7</accession>
    <name>A0A0F4JZP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_00480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000004">
        <property type="protein sequence ID" value="KJY39892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39892">
        <property type="protein sequence ID" value="KJY39892"/>
        <property type="gene ID" value="VR44_00480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.95"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="8949" checksum="44006CA9CCDA85C9" modified="2015-06-24" version="1" fragment="single">YGAAVLLKGATTLVAPGGGGAVRVNPTGTPWLATAGSGDVLSGLAGALLAGGLGGVDAGAVAAYLHGLAGRFAAGGAPVVAQEVAGALPEAWRSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZX2</accession>
    <name>A0A0F4JZX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945826.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6594"/>
    <dbReference type="EnsemblBacteria" id="KJY38566">
        <property type="protein sequence ID" value="KJY38566"/>
        <property type="gene ID" value="VR44_03275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7870"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="328" mass="35195" checksum="FC49E5405FA03D0D" modified="2015-06-24" version="1">MSRLQVVSGKGGTGKTTVAAALALALAREGRRTLLVEVEGRQGIAQLFGTEALPYEERKIAVAPGGGGGEVYALAIDAERALLDYLQMFYKLGSAGRALKKLGAIDFATTIAPGLRDVLLTGKACEAVRRKDKAGRFVYDHVIMDAPPTGRITRFLNVNDEVAGLARFGPIHNQAQAVMKVLKSPDTAVHLVTLLEEMPVQETADGIDELRAAGLPFGRVIVNMVRPHHLDEDTLRTAAEGRRPEIARALSRAGLGGARRGGLAERLVEPLLAQAAEHASRVELEREQRAVLAGLEVPTYELPLLGSGMELAGLYELATELRKQADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K071</accession>
    <name>A0A0F4K071_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945489.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39499">
        <property type="protein sequence ID" value="KJY39499"/>
        <property type="gene ID" value="VR44_01480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4729"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14276" checksum="7253760E031139D6" modified="2015-06-24" version="1">MSAGRPGPDRINPPELSPATGFSHAVAATGGRLVFLAGQTALDGSGKVVGQTLPEQFERALANLLTALAAAGGAPSDLARVTVYAVDVEDYRAHAAELGRVWRRLAGRDYPAMAVVGVVRLWDTEAMLELDGIAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K080</accession>
    <name>A0A0F4K080_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945499.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4194"/>
    <dbReference type="EnsemblBacteria" id="KJY39509">
        <property type="protein sequence ID" value="KJY39509"/>
        <property type="gene ID" value="VR44_01545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4742"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25996" checksum="A5EA27666D023189" modified="2015-06-24" version="1">MGDLKQHSLIKAQERLRDQVGHALRAALIAGELRPGSVYSAPGLAAELGVSATPVREAMLDLAREGLVEPVRNKGFRITEVSERDLDQYTELRTMIEVPTIGRITRTATREQLEELRPIAEEIVSSAREHNLIGYLEADRRFHLSLLALAGNERLVETVGDLRKRSRLYGLTGLDEAGKLVSSAEEHLELLDLMLTGDAEAAEACMVRHLGHVRSLWAQGRDEPVGRPQGRLGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0F7</accession>
    <name>A0A0F4K0F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_01195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945438.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39589">
        <property type="protein sequence ID" value="KJY39589"/>
        <property type="gene ID" value="VR44_01195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2954"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23974" checksum="FD1CDF26086A49F4" modified="2015-06-24" version="1">MIEHTGPEPSRPLRAWIRSSPGTHIWLLIVAVTSVVVAIAPDRLDHVLLHRNSSNIHQLDKYPLRALLSSALWIENPASLALYALLFELFHATVERWLGTLRWLVIVATAHIVATLASQKLLLMAIEDNRAPHSMTHVVDIGVSYGLAASVGVLTYRLPNPWRWLYLAGVVAFFAIPLLTGGSFTDLGHAISLAVGLLAWPLTLHPEPHEVHVSRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K461</accession>
    <name>A0A0F4K461_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">VR44_00400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007265919.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1048"/>
    <dbReference type="EnsemblBacteria" id="KJY39956">
        <property type="protein sequence ID" value="KJY39956"/>
        <property type="gene ID" value="VR44_00400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.78"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="14372" checksum="9C685E88D5EBFBDC" modified="2015-06-24" version="1">MARVSGVDIPREKRVEIALTYVFGIGRTRSKEILASTGVNPNTRVRDLAEEDLVKIREYVDANLRTEGDLRREIQGDIRRKIEIQCYQGIRHRRGLPVHGQRTSTNARTRKGPRRAIAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5J5</accession>
    <name>A0A0F4I5J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001679">
        <property type="protein sequence ID" value="KJY17270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17270">
        <property type="protein sequence ID" value="KJY17270"/>
        <property type="gene ID" value="VR44_40040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6347"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="23615" checksum="792218352D0E098B" modified="2015-06-24" version="1" fragment="single">TMADPALVELAISPDTDETDRARALRLLGFPAGAPLRVLAVRTRLPLDRAAALVCPAGPVKAALVNDVGVILATTLDPARLPPDARAGLGGATTPDRSWRQARTALRFTGPREPLVRHTDLGALALLAELPAHNPDVAAIARLAADPQDLQTLETYCATGSLRRAAELLHLHHSSVARRLEHITRTLNLDLTTPTGRLRAQLALTAWHLLTDSPLGNPVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5X7</accession>
    <name>A0A0F4I5X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_40260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001709">
        <property type="protein sequence ID" value="KJY16873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3734"/>
    <dbReference type="EnsemblBacteria" id="KJY16873">
        <property type="protein sequence ID" value="KJY16873"/>
        <property type="gene ID" value="VR44_40260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY16873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="32801" checksum="54F0A35794B1405A" modified="2015-06-24" version="1" fragment="single">HNSVIDSAVYREGRRVASPTTLAETFRRLREQPEGMAWIGLHRPTESELHSLAAEFNLHPLSIEDALEAHQRPKLERYGDTLFVVLRAARYLDAQEEVDFGELHVFVGPDFLITVRHGAAPDLSSVRRRMEESPDLLSLGPEAALYAILDAVVDGYAPVVAGVQNDMDEIETEVFRGDPEVSRRIYELSREMVEFQRATRPLVGMLHALMAGFAKYGTDEELQRYLRDVADHVTHTSERVDGFRQALTEILTVNATLVSQQQNAEMRALAEAGFEQNEEIKKISSWAAILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8H5</accession>
    <name>A0A0F4I8H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001613">
        <property type="protein sequence ID" value="KJY18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18262">
        <property type="protein sequence ID" value="KJY18262"/>
        <property type="gene ID" value="VR44_39620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6040"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="10191" checksum="850D3ED293FBC103" modified="2015-06-24" version="1" fragment="single">MTSIRSDVLSRALDAPAEPSLRPLPPEVAKLLRSLEAPPRLAAHLRAVHDVAVELADWVQGRYPELAVDRDAVLFGAATHDVGKTVHPEELSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB50</accession>
    <name>A0A0F4IB50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_39310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001574">
        <property type="protein sequence ID" value="KJY18894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18894">
        <property type="protein sequence ID" value="KJY18894"/>
        <property type="gene ID" value="VR44_39310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY18894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="246" mass="25203" checksum="39EF110716713AE7" modified="2015-06-24" version="1" fragment="single">FSGTVFFSQYFQLARGESPTMSGLLTIPMIGGLFVSSTVSGQIITKTGRWKAFLVSGGVLLTAGLGLLGTLRYDTPYWRIALFMALTGLGLGMMMQNLVLATQNQVAPEDLGAASSVVTFFRSLGGAMGVSALGAVMANRVTHYVKDGLAALGPKAAALGHGGTGGGGIPDLDKLPAPLRQVMESAYGHGVGDVFLYAAPSALLGLVLVLFIKEVALKSKPAVHAPDAEGAPGVPAQATDRAPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBU3</accession>
    <name>A0A0F4IBU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_39305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001573">
        <property type="protein sequence ID" value="KJY18938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4661"/>
    <dbReference type="EnsemblBacteria" id="KJY18938">
        <property type="protein sequence ID" value="KJY18938"/>
        <property type="gene ID" value="VR44_39305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5663"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY18938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="33587" checksum="0AC6317BCBFF8D54" modified="2015-06-24" version="1" fragment="single">MATTTPEGVRGGGRSETTSDGAPMTHSQIMKALSGLMLGMFVAILSSTIVSNALPQIISDLGGTQSSYTWVVTAALLSMTAATPLWGKLSDLFSKKLLVQISLVVYVLGSVVAGLSQNTGMLIACRVVQGIGVGGLSALAQIVMAAMISPRERGRYSGYLGAVFAVATVGGPLLGGVITDTSWLGWRWCFYVGVPFAVIALIVLQRTLHLPVVRRDVKVDWLGAFLISGAVSLLLIWVTQAGDSYDWISWTTLAMTGGAVALGLLFLLVESRASDPIIPLRLFRNKTISLASAASLFVGVAMFSGTVFFSQYFQLARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE98</accession>
    <name>A0A0F4IE98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001525">
        <property type="protein sequence ID" value="KJY19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19989">
        <property type="protein sequence ID" value="KJY19989"/>
        <property type="gene ID" value="VR44_38880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="17016" checksum="062AC53405834553" modified="2015-06-24" version="1" fragment="single">AVVLTRPGGGSSAQAGGEVFLQPAAASGPDPFTESTAARQATVPPQSAAPGASTAPATASASGTTATRSVNGSAPGLYGGTRDVASCDVERQIALLNAEPAKKGAFASALGVQPADVPGYLRGLTAVQLRMDTRVTNHGFRDGAPTAYQAVLQTGTAVLVDDRGVPRVRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEH1</accession>
    <name>A0A0F4IEH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001504">
        <property type="protein sequence ID" value="KJY20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952370.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001504.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20402">
        <property type="protein sequence ID" value="KJY20402"/>
        <property type="gene ID" value="VR44_38695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5417"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="26033" checksum="B42D7AA57782DF61" modified="2015-06-24" version="1">METQDLIPTPWPDLTELAELNFRHKVGIIAQRGSREAKVGRDIAVHAAKAGVPTVLYTGYPPEDTPGWLAVEQAPNPTPADVNNRAKLRINGELPAFVVIERYERISPTPQPPSDWDDVIDDPYDDPDYEPESWADKLMWSVREIRIDLPMLFTTVVDHTPELSRRMGKWLHIDHPAMVMTDVCKPTLVVHRTSPQTVEARMEVDHHEYRTGNRNTLRWAPLNRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEX7</accession>
    <name>A0A0F4IEX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease HaeIII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001514">
        <property type="protein sequence ID" value="KJY20234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20234">
        <property type="protein sequence ID" value="KJY20234"/>
        <property type="gene ID" value="VR44_38775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="48" mass="5298" checksum="235F60137ABF7521" modified="2015-06-24" version="1" fragment="single">MSSRHLALHDPEGLLEGELPLDRSTHERLAKAVLVWTGETGLQPADLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFP4</accession>
    <name>A0A0F4IFP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001483">
        <property type="protein sequence ID" value="KJY20860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20860">
        <property type="protein sequence ID" value="KJY20860"/>
        <property type="gene ID" value="VR44_38545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5360"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="25406" checksum="A9632833B8F08619" modified="2015-06-24" version="1">MVPVVQLYARDVPDLVFPAGTDLLQILWCPLVHEDDQYAANPRLHWRNTAQTAADVADGQPPRPHTAEEDYLPRPCTVSPTPALEYPNWDLPDELSEQIGERFEALQEERGFDYFEVATTQQSKVGGYPSWTQQPDWPDCTGCRTRMEHLLSVTATEAGMGRWLPLDERNPHRDQSETPSWRAEADPAALDAFGHHMYLGGGGMYFFVCRNCPDTPYTHRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP13</accession>
    <name>A0A0F4IP13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001365">
        <property type="protein sequence ID" value="KJY23775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952110.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001365.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23775">
        <property type="protein sequence ID" value="KJY23775"/>
        <property type="gene ID" value="VR44_37295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4872"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="88"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="33735" checksum="A3B59D862E795220" modified="2015-06-24" version="1" fragment="single">RTATAGRRVPRGDERLREHRGPVLPGWIAVVVGALALTGCAAVLWRAGVVPATLVAAFGVPPRPYHGLRATHWPPLAFLGVVTLLALGGLGRAKAGHAWVLTLFGSYRGTVRRTGLTWISPLLLRRRVDVRLRHWRSEPMPAVDSGGLALQVVVQVVWQVRDTARATLAVEDHIDYLAEQVESATARVLSRLPADAFHDDAPTLRDAEAVGEALTRTLAAETEAVGIEVFSAQPTRIEYAPEVAEAMRRRRIAAIDAKHRDTVLTAVVDAVDDTVHRLTSRGIVELDDYERKALVKDLTVAFYTGRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP35</accession>
    <name>A0A0F4IP35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">VR44_37225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001359">
        <property type="protein sequence ID" value="KJY23795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952097.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001359.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23795">
        <property type="protein sequence ID" value="KJY23795"/>
        <property type="gene ID" value="VR44_37225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4836"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="8367" checksum="E829A8A0CCE5AAA5" modified="2015-06-24" version="1">MPRTAKGIEVEGTVVECLRNATFKVQLPNGHQALAHISGKIRKNYIKILPEDRVLVELSAYDLTRGRIVYRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ03</accession>
    <name>A0A0F4IQ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001369">
        <property type="protein sequence ID" value="KJY23759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23759">
        <property type="protein sequence ID" value="KJY23759"/>
        <property type="gene ID" value="VR44_37360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4890"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9124" checksum="9CC5EC1BD2281AAE" modified="2015-06-24" version="1" fragment="single">GSGVGGRPGKGEIRGGVGVETGSGAVNRPPSLHSLTRMSDERSEQATPEKTSLEKASPENTPLEKTPLEKAPEGQAGQTEAAAAALSMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ09</accession>
    <name>A0A0F4IQ09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001368">
        <property type="protein sequence ID" value="KJY23764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952113.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001368.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23764">
        <property type="protein sequence ID" value="KJY23764"/>
        <property type="gene ID" value="VR44_37340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4886"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470036" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14759" checksum="3D703D8A86CE3136" modified="2015-06-24" version="1">MRTLGLAAVAAAGLLVATATSASAASVFDIGHGAGSCPDNYVCLWSEGNFIQGKFVYDHKFGSFASNQNVGDLGKLARTSTGDKGMQDVTSSVVNNTGSAICFYENNWYGGLEFRTGPHEQWASVPGWINDKISSFKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQI7</accession>
    <name>A0A0F4IQI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001371">
        <property type="protein sequence ID" value="KJY23753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23753">
        <property type="protein sequence ID" value="KJY23753"/>
        <property type="gene ID" value="VR44_37390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4897"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="PTHR14140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="34067" checksum="CC46A32B0359E4F9" modified="2015-06-24" version="1">MFDARLHGDLQRGISKLKDVDGAAVSDAIVLNGGYLDDDDSWHEIRYTGASPDVDRDPQTKRLKVSQRWDYPDNAALKRSYERGHPIRILRGHKGDARYSPSKGYRYDGLYRITQAATAISALPGRAGEPIEICQFILVRCPEAEQEVTVVERAASELVLFDDEEKFPEKRTSQVKRLVRDTAAAHRIKDLYDGQCQTCGIRLVGANCKPYSQGAHLKPLAEPHNGPDVERNILSLCPNCHVRLDLGAISIGEDWSVIERVAHTEPRTTLPRLLIKKGHGLHPSYAKYQRDWWDSFAQEETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRW1</accession>
    <name>A0A0F4IRW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001232">
        <property type="protein sequence ID" value="KJY24404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951763.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24404">
        <property type="protein sequence ID" value="KJY24404"/>
        <property type="gene ID" value="VR44_35455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4205"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9034" checksum="E37A42CB8A05DD8E" modified="2015-06-24" version="1">MVHEFTHAERIRYKRRQDAAYQAGEEAVANLKAALALAGLVLPSLCNDGPLGCRGFVRLGGCSVALANRLAEVIAAGARALEGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISB2</accession>
    <name>A0A0F4ISB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001149">
        <property type="protein sequence ID" value="KJY24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951491.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24910">
        <property type="protein sequence ID" value="KJY24910"/>
        <property type="gene ID" value="VR44_33970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3719"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469759" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="16883" checksum="E5407B84087A9694" modified="2015-06-24" version="1">MHHAKLAIAALALAATVGSVTSAAALGPTADQKVDGVIVVSGNTCTWTNARTSANPPTALTVDRTSINKPGGNLACDGGITASLNNNPAFTFDDATATARTDLIDITGSQSFVSCRYKATNIVWDRDGTTRKYVNRAFTATKASGSFLCPASVTTAAGGASMLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISE4</accession>
    <name>A0A0F4ISE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001231">
        <property type="protein sequence ID" value="KJY24413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951758.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001231.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24413">
        <property type="protein sequence ID" value="KJY24413"/>
        <property type="gene ID" value="VR44_35425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4199"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7830" checksum="578C8AB2FEE64808" modified="2015-06-24" version="1">MTVDPAEPDSFRDRFADPLDDEAPEADAAEQLTDVQPQEDDPLTGGDREDAPEADAAEQARVVPLDEEDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISK6</accession>
    <name>A0A0F4ISK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001190">
        <property type="protein sequence ID" value="KJY24639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24639">
        <property type="protein sequence ID" value="KJY24639"/>
        <property type="gene ID" value="VR44_34740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="15877" checksum="E5FC5D902D767007" modified="2015-06-24" version="1" fragment="single">MDLEPGKTVPAVPVPLDAELRVVYEAYLSEEPDAAPMSFEKLSAIRAEADAAGEAHEEHEDLSHGGRFTVFQPSVPGPDGAPGIPLLVCTPSGAPAARPALYFTHGGGFYGGDHRTGLDQILETAERFGATLISVGYRLAPEHPYPAQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITI6</accession>
    <name>A0A0F4ITI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_32770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001090">
        <property type="protein sequence ID" value="KJY25335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951269.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001090.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1406"/>
    <dbReference type="EnsemblBacteria" id="KJY25335">
        <property type="protein sequence ID" value="KJY25335"/>
        <property type="gene ID" value="VR44_32770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3366"/>
    <dbReference type="eggNOG" id="ENOG50348JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469812" evidence="5">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="8971" checksum="113A42CF473B4237" modified="2015-06-24" version="1">MSRIAKAFAITAVAGSTVAAGAGLAVADAGAHGAAVGSPGVLSGNVVQVPVHIPVNVCGNTVNVIALLNPAFGNTCVNASGGGGHHHTEGGSYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUL1</accession>
    <name>A0A0F4IUL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001091">
        <property type="protein sequence ID" value="KJY25329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951272.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25329">
        <property type="protein sequence ID" value="KJY25329"/>
        <property type="gene ID" value="VR44_32805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3374"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470268" evidence="2">
        <location>
            <begin position="33"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="36319" checksum="09C57B4345784B88" modified="2015-06-24" version="1">MTLQRRILILVCAVVLLAAVGVIAVVRAGSRADEKDRARPGGPEITPGAVSLAPGDGGRRMVFRNMAWGPHRDELASVPATAPDGPRTASGVKCLRFHAAAGTGICLQADKGGVQESYRAVVLDAGLKEVASRPLAGIPTRARVSPGGHLAAWTVFVGGDSYAGTNFSTRTSLLDLRTGKYDASLEDFTVLMDGKTYRNADVNFWGVTFAADEKTFYATLATGGRTHLVRGDLGERTVTVLRENLECPSLSPDGTRLVFKKRVPGLPEDAPWRLHVLDLASMRETPLAEQRSVDDQVVWTDDRTVVYSLPGDFGADLYSVPADGSGAATRVTASALAPAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUU0</accession>
    <name>A0A0F4IUU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CbxX/CfqX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_32570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001077">
        <property type="protein sequence ID" value="KJY25414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951235.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25414">
        <property type="protein sequence ID" value="KJY25414"/>
        <property type="gene ID" value="VR44_32570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3325"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="336"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="583" mass="63260" checksum="449B380BBB2C336D" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVR8</accession>
    <name>A0A0F4IVR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000983">
        <property type="protein sequence ID" value="KJY26102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950919.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000983.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26102">
        <property type="protein sequence ID" value="KJY26102"/>
        <property type="gene ID" value="VR44_30860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2673"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025335">
        <property type="entry name" value="DUF4241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14025">
        <property type="entry name" value="DUF4241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="465" mass="50296" checksum="B20B2C88F136C0CC" modified="2015-06-24" version="1">MAAEAVETVDVVEVLYCEGWDPAARAASAPMTEGEARRRDEMGEPYAVLLSHQGRPKALFHVDWRHAYLGLFFFDAHGRRTVEYVYRQLEPGRLHMSRFRQWGHTSDSEPEFPERGVRFELTVRPDGRGRRILNAGGALHVGADVPAEHRTVAKAEFGAWTTYVDARILGPSGGSVALVSVQPSEEGRASGAGASWSAPRPLEPGPLEELFVSGTRLTCGEDRIAVIGEPAPAGLLHLPTGSVLAGDPGTVNSSDLAFTITVPPGDYPVLVSTMRWEHEEWDGETPAAMLRILDEPTVSWELALRPEQDARLLGPGEFYGFGVDTGTACFMDASGRNTLPQLYEQEPGFEADSHSGMRSDPASGTNLIAFMSGFGDGSYPVWIGRDAAGAVTCFIADMLVLHGAEPQPPTVSSTAAHVLTFPALIDDRREAPFTDPAATSEFIAELIADIVSFRRERDAVRAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW27</accession>
    <name>A0A0F4IW27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001019">
        <property type="protein sequence ID" value="KJY25839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951030.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25839">
        <property type="protein sequence ID" value="KJY25839"/>
        <property type="gene ID" value="VR44_31480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045961">
        <property type="entry name" value="DUF6381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19908">
        <property type="entry name" value="DUF6381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6995" checksum="1D02C577CBF76344" modified="2015-06-24" version="1">MSNDSGPSERAREMRDKAQELEQAAQRATDPAERQRLRDKALHIRKKSEEQNGPGSGTMDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXV9</accession>
    <name>A0A0F4IXV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001065">
        <property type="protein sequence ID" value="KJY25496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951187.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001065.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5905"/>
    <dbReference type="EnsemblBacteria" id="KJY25496">
        <property type="protein sequence ID" value="KJY25496"/>
        <property type="gene ID" value="VR44_32315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3263"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470235" evidence="1">
        <location>
            <begin position="31"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="30143" checksum="639B98617D745C94" modified="2015-06-24" version="1">MLPWRRLLRPLAVLTLAAAALVAPTGAAQAASAPSSGWNNWSCKPSAEHPRPVVLVHGTFGNSVDNWLGFAPYLVHRGYCVYSLDYGQLPGVPLFNGLGPIDRSAGQLDAFVDKVLASTGAAKADLVGHSQGGMMPRYYLKFLGGAAKVNALVGLAPDNHGTTLSGLTQLLPYFPGAADLISTATPGLADQIVGSPFQQKLNAGGDTVPGVSYTVIATQYDEVVTPYRSAFLNGPDVRNVVLQDLCPLDLSEHVAIGLTDRIAWHETVNALDPAHAERTTCASVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYP4</accession>
    <name>A0A0F4IYP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950474.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000868.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27122">
        <property type="protein sequence ID" value="KJY27122"/>
        <property type="gene ID" value="VR44_28435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2012"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11939" checksum="F9C2167942AB4A05" modified="2015-06-24" version="1">MPEHEEAAGAAAAQGRLGAAELGREPGERASLVQFSSAFCQPCRATRRILAEIAGMVDGVEHIEIDAERNLALVRALGVEKTPTVLVLDGAGRIVRRAAGMPRKADVIAALGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ50</accession>
    <name>A0A0F4IZ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000851">
        <property type="protein sequence ID" value="KJY27292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene217"/>
    <dbReference type="EnsemblBacteria" id="KJY27292">
        <property type="protein sequence ID" value="KJY27292"/>
        <property type="gene ID" value="VR44_27970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1843"/>
    <dbReference type="eggNOG" id="ENOG5031WV2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="33" mass="3616" checksum="80AFB14DDC5DFBAA" modified="2015-06-24" version="1">MLEAFFTSLLVLVCVGVLAFTGLAVKKLYQGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZC3</accession>
    <name>A0A0F4IZC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000996">
        <property type="protein sequence ID" value="KJY26011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950954.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000996.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26011">
        <property type="protein sequence ID" value="KJY26011"/>
        <property type="gene ID" value="VR44_31055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="27417" checksum="2DA786D13CE8D18D" modified="2015-06-24" version="1">MDLDIVVAGQPLGFSLDCIDGEIVRAQVLTGPDIGSFETARTADDTGQITTLITAGSAESYAKHIQAFMHDRLNLQPLLNSLNETGTPGSRVARLLRSDLPARRRRQGAARRPDDGGLPGRLLQVFLDLPAAATLTRVRAAHDVRSSTAKRRKADAHGAFQQRREERERKESELREARARLAALPGPGEDESLTSLAAEAARRARVVADAQEAWEGLMRVHRRAVEHRRREERLLNDVCQTTRRPGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZY5</accession>
    <name>A0A0F4IZY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950429.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000858.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2562"/>
    <dbReference type="EnsemblBacteria" id="KJY27214">
        <property type="protein sequence ID" value="KJY27214"/>
        <property type="gene ID" value="VR44_28185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1879"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24255" checksum="241CD21E0B28555F" modified="2015-06-24" version="1">MSAATGTGRPGGGSARTGRKIVLWRHGQTSWNLERRFQGSTDIELTETGLAQARRAARLLASLKPDAIVASDLKRAAATAAELAAVTHLPVAHTEALRETYAGEWQGLTHEEIVEKYGEQYAAWKRGEPVRRGGGELETEVADRAAPVVLDHAGRLPEGGTLVVVSHGGTIRTTIGRLLRLEARDWESLGGLSNCCWSVLGEGARGWRLLEHNAGTLPEPVLGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J030</accession>
    <name>A0A0F4J030_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000854">
        <property type="protein sequence ID" value="KJY27254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene223"/>
    <dbReference type="EnsemblBacteria" id="KJY27254">
        <property type="protein sequence ID" value="KJY27254"/>
        <property type="gene ID" value="VR44_28005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="21747" checksum="295A01F2D426B21A" modified="2015-06-24" version="1" fragment="single">MSRSDVLVDADWVEAHLNDANVVIVEVDEDTSAYDKNHIKNAVRIDWKQDLQDPVRRDFVDQEGFEKLLSAKGISNDDTVVLYGGNNNWFASYAYWYFKLYGHQDVKLLDGGRKKWELDSRDLVDGKDVPNRPATEYKAKAQDTSIRAFRDDVVAAIGSLNLVDVRSPDEFSGKLLAPAHLPQEQSQRPGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0E7</accession>
    <name>A0A0F4J0E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ni/Fe hydrogenase formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000944">
        <property type="protein sequence ID" value="KJY26396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950787.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000944.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26396">
        <property type="protein sequence ID" value="KJY26396"/>
        <property type="gene ID" value="VR44_30140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2432"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10884" checksum="6B7E1BEE1C13B514" modified="2015-06-24" version="1">MCLAVPGRVLEIGEKDGTRMATVDFGGVQKEVCLEYLPDLRVGEYAIVHVGFALQRLDEESARKTLDLFAELGMLQEEFGDPWEQAARLGDEKEVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0X5</accession>
    <name>A0A0F4J0X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950111.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000784.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1190"/>
    <dbReference type="EnsemblBacteria" id="KJY27917">
        <property type="protein sequence ID" value="KJY27917"/>
        <property type="gene ID" value="VR44_26440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1472"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17261" checksum="188F306CDA25BBEF" modified="2015-06-24" version="1">MAVDELDTRILRLLIEQPRTSVREYARILGVARGTLQARLDRLERTGVITGSGPVLSPAALGHPVLAFVHIEVTQGHLDDVGDALAAVPEIIEAFSITGGGDLLTRVAARDNAHLEDVIQRLIRLPGVVRTRTEVALRERVAHRLLPLVEAVGRAARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1N8</accession>
    <name>A0A0F4J1N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_27175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000811">
        <property type="protein sequence ID" value="KJY27643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950250.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000811.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27643">
        <property type="protein sequence ID" value="KJY27643"/>
        <property type="gene ID" value="VR44_27175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1624"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="30524" checksum="DF2231FAD8CA8E40" modified="2015-06-24" version="1">MAGGRYVEAVSDAEFRLGAGECLVLVGESGCGKSVLASALLGLLPGNAETAGSALLPDGLDLLAADEDTLARTVRGRRVALVPQSPAAHLTPVRTVRSHLEETVRELTGSRTPRAAAEAAAARAAFPASHLDHHPHQLSGGLAQRAATALALVGDAPLLLADEPTTGLDRDLVERTADELRAHTRDSGRALLMITHDLAAARRIADTVAVMYAGRIVELAAAEAFFGEPGPRHPYARGLLDALPERAFTPIPGAPPELGDLPPGCAFAPRCALADATCRTVRPPLTEGVACHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2K1</accession>
    <name>A0A0F4J2K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000779">
        <property type="protein sequence ID" value="KJY27958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1199"/>
    <dbReference type="EnsemblBacteria" id="KJY27958">
        <property type="protein sequence ID" value="KJY27958"/>
        <property type="gene ID" value="VR44_26360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1455"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15110" checksum="68E6F4FE7E1AF866" modified="2015-06-24" version="1" fragment="single">GVLVLLFVHLVLAVEGLLWRAARMSSDVLVWLLGATSAWILAGVLDQPGNGAGWLFSGPGQEYLWLGLPILLGALVHDIGDALTVSGCPILWPLPVKGKRWYPVGPPKAMRFRAGSWVELKVLMPVFMLLGGIGGASALGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2L8</accession>
    <name>A0A0F4J2L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000718">
        <property type="protein sequence ID" value="KJY28567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28567">
        <property type="protein sequence ID" value="KJY28567"/>
        <property type="gene ID" value="VR44_25030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1097"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="57" mass="6309" checksum="C70983F22212013D" modified="2015-06-24" version="1" fragment="single">FGHSHIPWDTTAPGGLRLLNPGSPTDRRRQPFCTFMTAVVTGGELADIRLHQLPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J309</accession>
    <name>A0A0F4J309_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949782.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28732">
        <property type="protein sequence ID" value="KJY28732"/>
        <property type="gene ID" value="VR44_24695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.936"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="8291" checksum="1246ECE093350877" modified="2015-06-24" version="1">MTHQLAWFKSSYSSDAGGNCVEVAYHWQKSSYSGDAGGDCVEVAAHPAAVHVRDSKVTGGPIVTVAPGAWASFLATAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J352</accession>
    <name>A0A0F4J352_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_25700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949971.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1578"/>
    <dbReference type="EnsemblBacteria" id="KJY28294">
        <property type="protein sequence ID" value="KJY28294"/>
        <property type="gene ID" value="VR44_25700"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="19901" checksum="3D753453F3A44449" modified="2015-06-24" version="1" fragment="single">MTRTERWQRLLDLLVERDGLEVEPAAEALGVSAATIRRDLDQLAEQQLLVRTRGGAVPHGVSYELPLRYRTSRRAAEKRRISEAVAALITPGEVVGLTGGTTTTEVARALAARPDLAAGSPALTVVTNALNIAGELVIRPQFKIVLTGGVARPQSYELTGPLAQQTLGQLTVDTAVVGVDAFDPADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J396</accession>
    <name>A0A0F4J396_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000755">
        <property type="protein sequence ID" value="KJY28178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950020.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000755.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28178">
        <property type="protein sequence ID" value="KJY28178"/>
        <property type="gene ID" value="VR44_25965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1295"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="14593" checksum="9EE801BAC6C20305" modified="2015-06-24" version="1">MPQTATLTRSPDWPLQVKAPGTHDWERSATRWLRDLLPARYGSYLTLTRHHALLARHVQLQLQHEMRAVRVALHTSRAELPTMGVAESVIENTIRMYAIELEQLGRLSRGARLVSDALLAAAGPGQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3D6</accession>
    <name>A0A0F4J3D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_24585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949765.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28765">
        <property type="protein sequence ID" value="KJY28765"/>
        <property type="gene ID" value="VR44_24585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23055" checksum="9DCD0E6A58B9CB9F" modified="2015-06-24" version="1">MLHDLFPPGIQHALDLAGIFVFALAGALLAVRKNFDVFGIAVLALVTALGGGLFRDLCIGAVPPAAFSELSFFVTPLLAAALVFFLHPEVQRINRAINVCDAAGLGLFCVSGTTKAYEYGLGLTSSAALGVATAVGGGVLRDVLANEVPSLLRDREMYAVPAVVGASMIALFISFDLLNPLTTALAIVTTFVLRILAMQYHWRAPLAWNRRSSVAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3X9</accession>
    <name>A0A0F4J3X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949635.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000681.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29052">
        <property type="protein sequence ID" value="KJY29052"/>
        <property type="gene ID" value="VR44_23900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1039" mass="110459" checksum="FFA7797A1CB14E91" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5N2</accession>
    <name>A0A0F4J5N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000679">
        <property type="protein sequence ID" value="KJY29073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949623.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000679.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29073">
        <property type="protein sequence ID" value="KJY29073"/>
        <property type="gene ID" value="VR44_23825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.738"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="221"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="33955" checksum="153F807A6E88C9BC" modified="2015-06-24" version="1" fragment="single">VWAGLRPGLADRLREAEFLWRTSQADFMLPARPRPTLGEELDDVDRLDDERYVSAALVTTCGNRVHFTSPSPLGDAAARDLALDLAQARGPRQEAFAERLLADPAAVRARVRETLEACAEAFFDSAWADAAVRLATDLRLKNDLLKRQGPGAALASVSGAVTLAPDGDGILVDKLLDKVTHAHGTGVTFIPSVFGRPHLAVVHAPGWQPVVQYPVTEPGPSRPVSLDTVALRLEALSHPARLRLLRTLARGAHTNGELAHTWDMTPPEVSRHLALLRRAGLLVGRREGRYVRYSLNLSDLTALGTDLLAAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6I4</accession>
    <name>A0A0F4J6I4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29424">
        <property type="protein sequence ID" value="KJY29424"/>
        <property type="gene ID" value="VR44_22960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.529"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="498" mass="53208" checksum="FA201FABBAC2FA19" modified="2015-06-24" version="1">MGLPVTGDPPARGGVRHVYLPALRDAERELASAGGDRVRMILRGLLGDDEQVDAFVERIGSDLKRVAADPDVARVSEKINDPLRNMTVGAHPQTSQLALAEPTFASIARSLRVLLGDAVGQPLPLSASGLGYSNALFIATVMAELDAAADADLTLLLVEEPEAHLHPQLQTLLLRYLQQRARASRCRPAGDPSQPAGHLQVVVTTHSPILSAAASVENLVIMARCPAGLSSGWQAHPLPIPRLHLSPDRIRHLDRYLDATKSALLFASRAILVEGISELLLLPALAERVLAAPAGADARAVREASEALERFFGTTRVIVDGVGFEVYLRVLLAPVDGMSLGRRVALITDTDVAPDQPEPRRLQSLRALPLRWGSPGELHLAAAPRTLEPALWSADNIAALKAAFLRCAPRSKERWEQVAQAKDPALAFGELFVAKTSRTATGADEQVVKGTEISKGLFAQELADVLGDPAVEFTVPDYLADAIRFIVAIDSAAGVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Q8</accession>
    <name>A0A0F4J6Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000606">
        <property type="protein sequence ID" value="KJY29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29900">
        <property type="protein sequence ID" value="KJY29900"/>
        <property type="gene ID" value="VR44_21685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.216"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="33584" checksum="4AD93D491F0E91DE" modified="2015-06-24" version="1">MIMAVVGYVAFRPNNSAKNAEPSAPPAVAQTTDLLDRVTRFTSAFGVRGGYRTPTRAERDVLVEGVSALFGGNLEQARTRLAAVDYRVDTFTDGPGGRRYAEVADAASDSGPAARGWGRVYVDLGAPVRWSVQVPHPIADQDTERLGVAVLRGSPGGVMVLAGAHRKAAGGPDGGGAEDGEGDAAGDGSGSGGGGTGEADVAHRPDSVFHAVIAELTRRGLPGIQLHGFADSTVPGTGAVVSTGAGDAATADAARLAAGLAARGVRPCRAWSGSCRMSGRGNVQGRLAAELGTRFLHLELARSVRADPARRDETARAVTEVTAGWAGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Z8</accession>
    <name>A0A0F4J6Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949802.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4671"/>
    <dbReference type="EnsemblBacteria" id="KJY28701">
        <property type="protein sequence ID" value="KJY28701"/>
        <property type="gene ID" value="VR44_24800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.961"/>
    <dbReference type="eggNOG" id="ENOG503172B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13654" checksum="360EA73CC0AE7E18" modified="2015-06-24" version="1">MGLFGNAHRVDPASAQRDYARLLGHGEQVHVAYLLVRDTILFTDRRLVFVDKQGMTGKKVEYHSVPYRSITHFSVETAGHFDLDAELKIWISGSAAPIEKTFTKGVDIYEMQAVLTQFVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J704</accession>
    <name>A0A0F4J704_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_22665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949415.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000066_gene6657"/>
    <dbReference type="EnsemblBacteria" id="KJY29543">
        <property type="protein sequence ID" value="KJY29543"/>
        <property type="gene ID" value="VR44_22665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.465"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27822" checksum="03023809F76D3AD6" modified="2015-06-24" version="1">MTTAPHTPDARCARPVVELTGVTKEYPGGVKALRGVDLTVLDGELLGIVGPSGSGKSTLLHIVGTLDRPTAGRVAIAGHDVAALSDRALSALRSRHVGFVFQSFHLVPGISARANVAEGLLYSGLSRAERGRRAAAALERVGLGDRMEHRPHELSGGQKQRVAIARAVAGEPDLLLADEPTGALDTASGRSVMELLRELNGDGATIAVITHDQEIAASLPRSVRIRDGEIVSDAWHPYPRPGNPPPPHLPPRPGPHPERPEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7E8</accession>
    <name>A0A0F4J7E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949705.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28876">
        <property type="protein sequence ID" value="KJY28876"/>
        <property type="gene ID" value="VR44_24260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.832"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="24680" checksum="9987A2A07890FB1A" modified="2015-06-24" version="1">MISLDGKVVVITGAARGQGAEEARLCARAGARVVVTDLREEEGRAVAAELGGRGLFVRHDVADAGSWAGVVREAVAAFGTVSALVNNAALWRTAHVEEQSAEGFEELLRVNLLGPFLGIQAVAPVLRAGGGGSVVNVSSTAGLVGIPGHAAYGSTKFGLRGLTRSAALDLAGDGIRVNSVHPGAIDTPMVAGAVEGRDWSHVPLGRMGRPGEVGELVLFLCSEASSYVTGAEFVVDGGMTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7H4</accession>
    <name>A0A0F4J7H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_22150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949317.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5163"/>
    <dbReference type="EnsemblBacteria" id="KJY29739">
        <property type="protein sequence ID" value="KJY29739"/>
        <property type="gene ID" value="VR44_22150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.314"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="33381" checksum="54BD52EF1BBF13FB" modified="2015-06-24" version="1">MALGTASTWSDRAHTVRDLLASGASYSFEFWAPRTEKGERNLWNALRRIEAVSPSFVSVTYGAGGSTRGGTVRATQQIAADTTLTPVAHLTAVDHSIAELRHVIGQFADAGIRNMLALRGDPPGNPMGPWVKHPEGVDYAADLVRLLKESGDFCVGVAAFPEMHPRSEDWDTDIRHFVDKCRAGADYAITQMFFDPEHYLQLRDRVQKAGCETPIIPEVMPVVGIKQLDRLPQLSDAVFPDAVKDRMLAVKDDPVAVRSIGIEFATEFCARLLSEGVPGLHFITLNNSTATLEIYENLGLHQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J852</accession>
    <name>A0A0F4J852_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949203.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29959">
        <property type="protein sequence ID" value="KJY29959"/>
        <property type="gene ID" value="VR44_21550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.188"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038500">
        <property type="entry name" value="Antitermination_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8648" checksum="E84E899A8C0EC4BE" modified="2015-06-24" version="1">MLIASALILAALAAYTLLCMASPFGTCRKCDGAGAKPTLHRTGKVMVKPCRRCKGHGKRLRVGRRLHNHSRQIHRAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8C6</accession>
    <name>A0A0F4J8C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6646"/>
    <dbReference type="EnsemblBacteria" id="KJY30440">
        <property type="protein sequence ID" value="KJY30440"/>
        <property type="gene ID" value="VR44_20450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8800"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18447" checksum="520B305671555CD7" modified="2015-06-24" version="1">MNEAPAPEQVGYRGPTACAAAGITYRQLDYWARTGLVEPSVRPAYGSGTQRLYSFRDVVVLKIVKRFLDTGVALQNIRTAVQHLRGRGFSDLERMTLMSDGATVYECTSPDQVVSLLQGGQGVFGIAVGVVWRDVENALSQLHGERVDTGETVVGHNPADELAARRNRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8K0</accession>
    <name>A0A0F4J8K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30722">
        <property type="protein sequence ID" value="KJY30722"/>
        <property type="gene ID" value="VR44_19715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8562"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12039" checksum="8CDB2246EB59EA9A" modified="2015-06-24" version="1" fragment="single">AYAWSKIVAPAEGGEEPENGEDPGDPGNGEDPEEGRGPGNDPDRGNGNGDAHAPGGAPAGPNGGSEVVVPVHIPGGKGRLAETGADARDTGRLLGIAALVTAAGGGLIIGTGRHRRRRRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8R6</accession>
    <name>A0A0F4J8R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949126.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000588.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30138">
        <property type="protein sequence ID" value="KJY30138"/>
        <property type="gene ID" value="VR44_21160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8955"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="183"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36947" checksum="6878ABF87A860559" modified="2015-06-24" version="1">MPSAHPSSSASSPSLAVIDLSRADDPAERDDFLKQLHAAARDTGFLYLTGHGITEAETARILELTRAFFALPEADRLAVSNLNSPHFRGYTRIGHELTGGASDWRDQLDVGAERPAPELGPDDPAYLWLEGPNQWPAALPELREAVLGWQERLAAVAHRLLRELLTAIGAPPDFFDAAFADRPHLHTKLIRYPGSAPSGADQGVGAHKDYGFLTLLLQDGVGGLQVVRDGGFVDIPPMPGAFVVNLGELLEIATEGYLVATDHRVVSPPGAVERFSVPFFYNPRLDAVIDTVPGEYLRAAPGVAHDASNPLHAEYGRNELKGWVRAHPAVARRWHPSLVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8U8</accession>
    <name>A0A0F4J8U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949084.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30229">
        <property type="protein sequence ID" value="KJY30229"/>
        <property type="gene ID" value="VR44_20915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8913"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19682" checksum="C194E3BF2FA5CCBF" modified="2015-06-24" version="1">MSNRLLSRTHQRARLLGPGDRHESCDERADRLWGELLHEVRVALTAVQLLLAFLLAAPFSQVFGRLPTTDHLLYVVCVVLGGAATGALTAPVCLHRLVTGLGVKPEAVVWAARLTLTGLVLLLGMVALALLIVLRTVLGAPTALVVDLTVVVWCAGCWLVPTALVRRTAVLRRGDTLFETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8W8</accession>
    <name>A0A0F4J8W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000551">
        <property type="protein sequence ID" value="KJY30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948917.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000551.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30630">
        <property type="protein sequence ID" value="KJY30630"/>
        <property type="gene ID" value="VR44_20000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470498" evidence="2">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="12958" checksum="47FF5762DAAC6633" modified="2015-06-24" version="1" fragment="single">MPPTRIRHRLTGVAAATLVIAAAAPASAAPAGGTTPSATVSPGTVSPGGRVGLNVDGCTTRTGRASSRVFNTVTLAPGSATASNLSGSATVFSDATPGSYPVTFECGGRRVNVTLQVAPGAARGGLGGSMDSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA92</accession>
    <name>A0A0F4JA92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000548">
        <property type="protein sequence ID" value="KJY30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948898.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000548.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3098"/>
    <dbReference type="EnsemblBacteria" id="KJY30668">
        <property type="protein sequence ID" value="KJY30668"/>
        <property type="gene ID" value="VR44_19900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8599"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="30075" checksum="0086A9B3A37419D6" modified="2015-06-24" version="1">MAGKLAVIGAGLMGSGIAQVSAQAGWDVVLRDVTDAALTRGTDGIKASYDKFVSKGKMTAEDAEAALARITTTTDFDAVADVDIVVEAVFEKIEVKHEIFRTLDELVREDTVLASNTSAIPITKIAAVTKRPERVVGAHFFSPVPMMQLCELVRGYKTSDETLATTRAFAESVGKTCIVVNRDVAGFVTTRLISALVVEAAKLYESGVASAEDIDIACKLGFGHAMGPLATADLTGVDILLHATSNIYTESQDEKFAPPELMRRMVDAGDIGRKSGQGFYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAR9</accession>
    <name>A0A0F4JAR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_19290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000528">
        <property type="protein sequence ID" value="KJY30909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948789.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000528.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5427"/>
    <dbReference type="EnsemblBacteria" id="KJY30909">
        <property type="protein sequence ID" value="KJY30909"/>
        <property type="gene ID" value="VR44_19290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8464"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="80"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="23943" checksum="185160CAACD010AA" modified="2015-06-24" version="1">MSFGDPNNPYGQQQPPQGQPGYGYPQQAPQGVPPQAGYGYPQQPPQPYGVPGQYPGQPGAPVPEGFANVPGLGPVEVGTYGARFGARLLDMIFAYIVVIILNIIIFGAAFAGSSSSSDSAASGLAVGSLIASLLVSALTFIFYDVIFVSTMGSTPGKMILGMRIVNSRTGQKPGFGPALVRWGFPIGLGYITCGLGYILIVISPFFDNTGQLRGWHDKAANTLVIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBR8</accession>
    <name>A0A0F4JBR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_17440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948435.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5591"/>
    <dbReference type="EnsemblBacteria" id="KJY31807">
        <property type="protein sequence ID" value="KJY31807"/>
        <property type="gene ID" value="VR44_17440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8025"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20506" checksum="E1A04F0B2F804296" modified="2015-06-24" version="1">MLTVGDKFPSYDLTACVSLEAGKEFAQIDQKTYEGKWRVLFFWPADFTFVCPTEIAAFGKLNDEFLDRDAQILGISGDSEYVHHAWRKDHADLRDLPFPMLADSKHELMQACGIQGEDGFAQRAVFIVDPNNEIQFSMVTAGSVGRNPKEVLRVLDALQTDELCPCNWNKGDETLNAGALLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC19</accession>
    <name>A0A0F4JC19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000560">
        <property type="protein sequence ID" value="KJY30501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948972.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000560.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30501">
        <property type="protein sequence ID" value="KJY30501"/>
        <property type="gene ID" value="VR44_20295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8768"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="33157" checksum="C29EE8FD7F821D83" modified="2015-06-24" version="1">MKVGVIGLGDIAQKAYLPVLTTRPGVQVHLQTRTHATLERLGAVHHVPEGRRHASLGALIAQGLDAAFVHAPTGVHPEIVGRLLEAGVPTYVDKPLAYELADSRRLVELAEERGTSLFVGFNRRYAPGYAQCADLPRDLIVMQKNRVGLPEDPRTLVLDDFIHVVDTLRFLLPGDADHIDVRAVVREGLMSHVVLQMSGEGFTALGIMNRLSGSTEEVLEVSGQDSKRQVVNLAEVIDHKGQPTVRRRGDWVPVARQRGIEQAVDTFLEAVEGGKVLSARDALLTHELCERVVLTALEQTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCS5</accession>
    <name>A0A0F4JCS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000480">
        <property type="protein sequence ID" value="KJY31614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000480.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31614">
        <property type="protein sequence ID" value="KJY31614"/>
        <property type="gene ID" value="VR44_17795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8101"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="15816" checksum="7503950B6202B2BF" modified="2015-06-24" version="1">MSDALDVSLRLVKAQTALVRRFDSRLGALFGVSLADFLVLLHLGRAEGGRMRRVDLAGALGLTASGVTRGLAPLERIGLVVREADARDARVAYAALTDAGRERLADALKAAEQVAADVFAAPEWAGADVEQLSGLLTRLGGTGLPEDHGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCV9</accession>
    <name>A0A0F4JCV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948334.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32030">
        <property type="protein sequence ID" value="KJY32030"/>
        <property type="gene ID" value="VR44_16890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7814"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="11877" checksum="5CF031F26052FF0D" modified="2015-06-24" version="1">MAIELLDERKAGRLLAVEDDAVVGFIAYFVLEAEPHALVAVHTVVEPGHEGRGIAGDLVGAFYRIAAAEGVPVVPLCPYAARWAAKHPERAPAAPAGVVDAAVAQLDRDSALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCY2</accession>
    <name>A0A0F4JCY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_16780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32055">
        <property type="protein sequence ID" value="KJY32055"/>
        <property type="gene ID" value="VR44_16780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="9">
        <location>
            <begin position="319"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="424" mass="43176" checksum="7CF3C94EB33AFB30" modified="2015-06-24" version="1">MPGNRPPRSGRSCAAASSKRDKVLAGVCGGLGRYFDLDPVVFRIVLGVLAVTGGVGLVFYGFAWLLLPLEGEEDSEGRKLLTGRVEGATLAAVFSALVGCALFLSMLDNGVMGAFSVLVILALGGAAYWSRRHRGAAAPEAEAPGTHRPAPPETQAPPAPSSPSWWRDPLVKDGTTGPVGSTGYLWGPDDSADDSPGTVPGAAPAKPRPVPAYGQGRGGIGGRVFVLALLAGGIGTASVWHGSPLGHALQVGLACALAVFGLGLAVSSLKGRTGFGTVLLGLVTAVLLAAATALPREVGTDWHNVDWRPAAVADVKPLYSSGTGLATLDLSRLDVPKGATVSVRASIEAGRLKVVVPREVTAKADVSIDLGDIQLPGDRSVRIKNGGENRRATLPPTAGTEAGGTIELHLDAGVGQVEVARAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD26</accession>
    <name>A0A0F4JD26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000473">
        <property type="protein sequence ID" value="KJY31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31714">
        <property type="protein sequence ID" value="KJY31714"/>
        <property type="gene ID" value="VR44_17635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8093"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9418" checksum="97A772F29FE33C53" modified="2015-06-24" version="1" fragment="single">MAVVALAGGLGAPGVTTAALALLMTWPMPAGHRVVLAEADPDGGAVLPGALQGTLDNSRGMRNLAVAARQGREQLVEAFWRQLVDVTDAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEE7</accession>
    <name>A0A0F4JEE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000434">
        <property type="protein sequence ID" value="KJY32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32174">
        <property type="protein sequence ID" value="KJY32174"/>
        <property type="gene ID" value="VR44_16470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7692"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="11286" checksum="CB1B22E9044FCD0D" modified="2015-06-24" version="1" fragment="single">LYTSEEDRRYLSRLDVPGVAPRPCGSAGLEYLRVARGEMDALAFTWPSAWDHAAGLLLVGEAGGAQSTVDRVPFRVDRDNALPFAVGRDEATTVRVRELLRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG06</accession>
    <name>A0A0F4JG06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947893.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3313"/>
    <dbReference type="EnsemblBacteria" id="KJY33130">
        <property type="protein sequence ID" value="KJY33130"/>
        <property type="gene ID" value="VR44_14470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7155"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="26963" checksum="F5EE96B71E1E288C" modified="2015-06-24" version="1">MTRWYEGPLAAFDTETTGVDVEQDRIVSAALVVQECAGGRVRATRWLVNPGIPVPRGATEVHGLTDEHLQRHGRWPAPVVEEIARALSEQQMAGRPVVVMNAPFDLTLLDRELRRHRASTLARYLDDRPLTVLDPRVLDKHLDRYRKGRRTLTDLCAHYGIELEGAHDASADAMASLELVRAVGRRFAARLERLTPAELHQLQAVWHAAQARGLQAWFARQGTPEAVDPHWPLRPEVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGP2</accession>
    <name>A0A0F4JGP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947804.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33395">
        <property type="protein sequence ID" value="KJY33395"/>
        <property type="gene ID" value="VR44_13995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7101"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="55"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="55125" checksum="205E422C5DD3D877" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH22</accession>
    <name>A0A0F4JH22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000422">
        <property type="protein sequence ID" value="KJY32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948210.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000422.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32276">
        <property type="protein sequence ID" value="KJY32276"/>
        <property type="gene ID" value="VR44_16230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7669"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15334" checksum="C27A8BCB19E32300" modified="2015-06-24" version="1">MITMYAWPSTADGPDALPMVHFTTEEQSGGELSPEGMPVWLFDTAIREGGWANFEDFEAWAAPAEGWQAFYRREDDVLAVTGPGPCEGWYQGRLGADDEWVKAAATQQSVVLLAAPVQHPSLYAYAVEAGAGFALLVPLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHH6</accession>
    <name>A0A0F4JHH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">VR44_14235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="JZWV01000367">
        <property type="protein sequence ID" value="KJY33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3354"/>
    <dbReference type="EnsemblBacteria" id="KJY33264">
        <property type="protein sequence ID" value="KJY33264"/>
        <property type="gene ID" value="VR44_14235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7194"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="18225" checksum="BCA072507BD6EBB6" modified="2015-06-24" version="1">MTAGPLVVLVGPMGSGKSTVGALLAERLGVPYRDTDADIVAAQGREISDIFVDEGEPYFRELERQAVAAAVAGHTGVLALGGGAVLDPGTRALLAGLPVAYLSMDVEEAVRRVGLGAARPLLAVNPRRQWRELMEARRPLYTEVARVVVATDERTPEEVAQAVLDALELKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI57</accession>
    <name>A0A0F4JI57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32646">
        <property type="protein sequence ID" value="KJY32646"/>
        <property type="gene ID" value="VR44_15500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7501"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470566" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9534" checksum="6210200C8077FF2D" modified="2015-06-24" version="1">MATVAVPVKVPLPSPLRSTRPPAKAADFTYAPFSELLTVMTTLSPGRPKSVDSWRVAGAGVGFGFGEPALTVSWAVAWSLVPSGAEPVRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIE8</accession>
    <name>A0A0F4JIE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_12550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947537.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34122">
        <property type="protein sequence ID" value="KJY34122"/>
        <property type="gene ID" value="VR44_12550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6571"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="45790" checksum="CE2DDCF2EA74472F" modified="2015-06-24" version="1">MKGTLAQVRTYERSVQLLMVNQFTINLGFYMLMPYLATHLAGPLGLAGWTVGLILGVRNFSQQGMFLIGGTLADRLGYKPMIVAGLVLRVAGFATLGLVDSVPALIAASAATGLAGALFNPASRAYLAADAGERRVEAFALFNVFYQAGILLGPLVGMVLTGVDFRVTCLVAAGIFAVLSLVQIRALPQRRGEDPAQRADGPREGVLTQWRGILRNRPFLLFSVAMIGSYVMNFQVYMALPLEVRRTGGEGRFGTAAVAVLFAVSGLSTILFQTRVTAWCKARMEPGRALAWGLFAMGAAFLPLLAATALPAPESVTGTRLLAAVPPALSALLLALGTMIAYPFEMDTIVRLSGDRLVATHYGLYNTVCGVGIALGNLLTGAALDAARAAGMSALPWLALFVLGLGCTAALYGLQRTGRLAPPPREASAREAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIR4</accession>
    <name>A0A0F4JIR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_15155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000388">
        <property type="protein sequence ID" value="KJY32856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948009.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000388.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32856">
        <property type="protein sequence ID" value="KJY32856"/>
        <property type="gene ID" value="VR44_15155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7450"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY32856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9040" checksum="A3047C198B529666" modified="2015-06-24" version="1">MGIIGWIVLGLLAGIIAKAIMPGRDPGGCVITILIGIAGALLGGWLGKVIFHVESIDGFFQLSTWIAAIVGALILLAVYRLVAGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIX1</accession>
    <name>A0A0F4JIX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947985.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32911">
        <property type="protein sequence ID" value="KJY32911"/>
        <property type="gene ID" value="VR44_15000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7418"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16443" checksum="F9971AB471075D3F" modified="2015-06-24" version="1">MSIDVSGMIECRPGARLWGLDDEDSVWQVAIDLFLLNRGNAYDGFACLFGIRNTFGFRPVAEGRGFPSDASEGLASEFASYGGPADVFGTTWLTWAEVAAVDWGETDSSGTRSRGMVAGDESDWGRVWIVMRTLSEVHGAKNVRLVVWFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ32</accession>
    <name>A0A0F4JJ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33788">
        <property type="protein sequence ID" value="KJY33788"/>
        <property type="gene ID" value="VR44_13220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6862"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="24984" checksum="CBBEB54C28035A22" modified="2015-06-24" version="1">MTDQSPEPRDPWAPPERQAGAPGGSPQQTPPGGGTPGAPSVHDQQTVAGMPGADWAPPANPSGPAPAPGPAPAAGHTPGPVPGPVPAPAPPQIPGAAYGYPAQPAYGQPGPAAPQPGYGYPGYQPPAGYPGTPGYPPAPGYPGYTGYHAYGPGPSNGFGVTALVLGILSVVGCFTSFLAIALGIAAVVFGALGRGKATRGEATNGGVALSGIILGAIGIVLGAVILVIAFTGIMSGNFDETPDGGSHSNTQVRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ38</accession>
    <name>A0A0F4JJ38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000381">
        <property type="protein sequence ID" value="KJY32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32956">
        <property type="protein sequence ID" value="KJY32956"/>
        <property type="gene ID" value="VR44_14880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7643" checksum="3F95772DC8A4FE4B" modified="2015-06-24" version="1" fragment="single">MYRPAGRLPATPAEKTVCEIFASVLGLQEAGMDDDFFAHGGHSLLATRLAGRIGAELGVRLNIRDLFETPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKD0</accession>
    <name>A0A0F4JKD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000274">
        <property type="protein sequence ID" value="KJY34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947353.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000274.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34645">
        <property type="protein sequence ID" value="KJY34645"/>
        <property type="gene ID" value="VR44_11575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6225"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26346" checksum="A48FCCF0BA442B79" modified="2015-06-24" version="1">MKTVLITGASSGYGRETALYFHSQGWNVIATMRTPRAGVLPESDRLRVVELDVTKPQSITAAFEAAGSIDVLVNNAGVPSISVFEGTPMARVREVFETNTFGVMATTQAVLPQFRERGSGVVVNVTSSVVLGHMPLSAVYKASKMAIEGFTASLALELAPFGVQAKTVEPGACLTTNFAANATKGASLDELVPAPYASWAKKAMGDFTSQDLFTKESDVAETVWRAVHDTTGQLRFPAGPDAVSLSQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMA8</accession>
    <name>A0A0F4JMA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000229">
        <property type="protein sequence ID" value="KJY35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947129.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000229.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35345">
        <property type="protein sequence ID" value="KJY35345"/>
        <property type="gene ID" value="VR44_10365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5945"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="31894" checksum="CDA788292843709C" modified="2015-06-24" version="1">MVARVRTVLADVHPDDLGVCDAHDHLFLRSPKLPGRELDDVPAARSELAAFRATGGASLVQWTPYGMGRRTAELPALSSATGVHVVCATGLHQAAHYEPEFLDAVRGRLAHVFVSELTTGIGGSGVRAGLIKVAGGFHALDAHARWTMAAAAEAHHETGAPIAVHLEHGTGALDVIDLLCDELGVPPHRVILGHLNRSPDGVVQRQAAEAGCYLAFDGPSLAHHATDWRMPDAVKALADAGFGHRLLLGGDTVVSGARSVDGGPGMPYLLRRVRPRLVAALGAELVGHILTRNPGRAFAVDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMG2</accession>
    <name>A0A0F4JMG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000214">
        <property type="protein sequence ID" value="KJY35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947049.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000214.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35542">
        <property type="protein sequence ID" value="KJY35542"/>
        <property type="gene ID" value="VR44_09920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5533"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14426" checksum="BE3E39DDF2E3F0F0" modified="2015-06-24" version="1">MSFDEEWATARATAAANAALRLDHAGSAPGTPDLALNQDHIGAIGSEAHKLHSRLQTDGRHAATASTEAAGALSREGFATGAALAKANSRWESQVKTLVAACAQISNGLNYSLSSHAKEEQQLYAEFTSSKIDEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN44</accession>
    <name>A0A0F4JN44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">VR44_09200</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946911.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35787">
        <property type="protein sequence ID" value="KJY35787"/>
        <property type="gene ID" value="VR44_09200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5104"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJY35787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="27066" checksum="5208719C7BF697FC" modified="2015-06-24" version="1">MTDSTDDRPPLPPAERATLADGIRFAFGTLTVLPARITRWDRPAARTGMACAPLAGLAVGLLATVPGVLLLLLGGGPLLAAAVTVAAPAALTRGLHLDGLADTADGLGSAKPAEDALRIMKQSDIGPFGVISLLFVLLIQVAALADAYAGSWTRGALAAVTAAVTARLAMTLASRRGVPAARPGGLGAAVAGVVPRRTAAQVGALVLAAAVLAALPAGLPAAAQHAAAVLAGLLAAELLLRRCVHRFDGVTGDVFGAVCETAATTVLVVLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN94</accession>
    <name>A0A0F4JN94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946985.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35660">
        <property type="protein sequence ID" value="KJY35660"/>
        <property type="gene ID" value="VR44_09600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5322"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23606" checksum="603B9718E235C59C" modified="2015-06-24" version="1">MTVRVVLADDQPLARSGLRVLMADHSDLEVVGEAATGAEAVRLVNDTRPDVVVMDIRMPGMDGIEATRLITAGPATTRVLVLTTFDEDDHVYGALRAGASGFVVKDMALDDILAAIRVVAAGDALIAPGVTRRLIADFVGRPAAVRERSPRPVEGITEREREVLTLVGRGRSNTEIAEDLFITVATAKSHVSRLLTKLGARDRIQLVITAYEMGLVTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQL9</accession>
    <name>A0A0F4JQL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000175">
        <property type="protein sequence ID" value="KJY36149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946770.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000175.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36149">
        <property type="protein sequence ID" value="KJY36149"/>
        <property type="gene ID" value="VR44_08435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4588"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="559" mass="61388" checksum="E2D8910ADEC44FEE" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR92</accession>
    <name>A0A0F4JR92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946500.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36887">
        <property type="protein sequence ID" value="KJY36887"/>
        <property type="gene ID" value="VR44_06975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3610"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="18331" checksum="7C6A7A221CD45615" modified="2015-06-24" version="1">MLTTDRLRLRPLTTNDADWWVHLHADEEVGRYVGHYTHAQATTRLHDIQQQWTERGHGLCAVELRTTGETIGRCGLNWWEQFQETEIGWTFARPHWGHGYATEAARAVLDWGFGPLGLDRITAMIHHGNTGSTAVAARLGFTPLREDTVLDRPCTVYALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRA2</accession>
    <name>A0A0F4JRA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946510.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36897">
        <property type="protein sequence ID" value="KJY36897"/>
        <property type="gene ID" value="VR44_06965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3608"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="9113" checksum="5296B71E23433558" modified="2015-06-24" version="1">MSEKARILFDALDLNHDGELTRLEVISALRSKGPTLAARGVLPFWGVGDADASSALFDAADKNGDQVLSFEEFEAEVDRRFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRE8</accession>
    <name>A0A0F4JRE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000138">
        <property type="protein sequence ID" value="KJY36770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946547.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36770">
        <property type="protein sequence ID" value="KJY36770"/>
        <property type="gene ID" value="VR44_07250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471288" evidence="2">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="33385" checksum="D093699B2D6DDED3" modified="2015-06-24" version="1" fragment="single">MLRAPSLSRVLARPSGTARACVLVVLLGTTGVAILELVREQTGTAGFCVGLGLALLPVPPLMAAFRWLGRAAPGPWRQLLFCFGWGACTAALIAILANSFATEWMAEAADPSAADLLGSVAVAPVVEESAKAAVLFAVFAFRRPPSAGAADGFVFAGFTATGFAFTENVLYLGNAFEEDLAKGTGALDSVTAATFFVRVVLSPFAHPLFTVLTGLGLGVAAAGGRRSRRAGPPLFGLALAMAAHAAWNGSSHVGRYGFYWVYGCVMVPVFGLLLWLAVRMRRERLRVVAAELSVYSAAGWIGPAEVPALASMPARSRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRX9</accession>
    <name>A0A0F4JRX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000155">
        <property type="protein sequence ID" value="KJY36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36508">
        <property type="protein sequence ID" value="KJY36508"/>
        <property type="gene ID" value="VR44_07890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="570"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="708" mass="74159" checksum="53B3F446F7F13E46" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSU2</accession>
    <name>A0A0F4JSU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946248.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37417">
        <property type="protein sequence ID" value="KJY37417"/>
        <property type="gene ID" value="VR44_05630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1941"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="36216" checksum="455D846E753C4B87" modified="2015-06-24" version="1">MTTNENTSAPATIPAARRLGATGPSVFPLGLGCMGMSALYGEADRSESLATIHAFLEAAPEGMNTLLDTGDFYGMGHNELLINEALRTAPTAAREQALTSVKFGALRTVEGGFTGYDGRPEAVKNFLAYSLQRLGRDHIDIYRIARVDPDVPIEETVGAIAEAVQAGHVRHIGLSEVGADTLRRAAAVAPISDLQIEYSLISRGIEDRILPTARELGIGVTAYGVLSRGLIMSRGLISGHFSRDRALAPGDFRGMSPRFQGENLARNLDLVEALRKVAAEQGVSVAQTAIAWVLAQGPRHGVDIRVELSEADLAAIEAAVPAGAASGDRYPAAQMAHLDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSZ8</accession>
    <name>A0A0F4JSZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_05940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946306.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2616"/>
    <dbReference type="EnsemblBacteria" id="KJY37310">
        <property type="protein sequence ID" value="KJY37310"/>
        <property type="gene ID" value="VR44_05940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2402"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17743" checksum="F0CCB528AEFB2850" modified="2015-06-24" version="1">MRVYLGSDHAGFELKNHLVDWLKNNGHEPVDCGPHIYDAVDDYPPFCLRAAEKTAADADSLGIVIGGSGNGEQIAANKVKGVRAILAWSVETAKLGREHNNANVISVGGRMHTQDEATSFIEAFLATPYSDEERHTRRIDMLSAYEQTGELPPIPAHHPQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTB7</accession>
    <name>A0A0F4JTB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36988">
        <property type="protein sequence ID" value="KJY36988"/>
        <property type="gene ID" value="VR44_06735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3426"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19799" checksum="2DF4F1D34C7B213F" modified="2015-06-24" version="1">MAHVTDTDPVLRALAHPLRLRMLSLMWPGPLSAAELARELDVSHALASQHLRRLDAVGLVELAEQRTRRGGRERRYRTVRGTPLSDRHEGAPMLAETMAHTLRERAGRRLEASEGVTVDAELWVDPRIWQDVRRRLTELAVELHDAAQPAHAPGTIPLGVSMMAFPLQDTAPADPPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTH4</accession>
    <name>A0A0F4JTH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946179.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37667">
        <property type="protein sequence ID" value="KJY37667"/>
        <property type="gene ID" value="VR44_05280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1690"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="12305" checksum="9D139C1770DB26C6" modified="2015-06-24" version="1">MTTTVEYIRYKIASQDQQAFEDAYARAAEALAASPECIDYELAHNTEDTERYILRIRWTSVDAHLNGFRKGEHFPAFFQAIRPYVTNIEEMQHYSATGVVGPGKAAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV02</accession>
    <name>A0A0F4JV02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">VR44_04475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946035.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37980">
        <property type="protein sequence ID" value="KJY37980"/>
        <property type="gene ID" value="VR44_04475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.702"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY37980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26017" checksum="4217447F6BE4985E" modified="2015-06-24" version="1">MSKLRVAVLGAKGRIGSEAVRAIEAAGDMELVAALGRGDELQTLADAGAQVAVELTTPDSVMDNLDYLVGHGIHAVVGTTGWNEDRLGRLNGWLAGSPETGVLIAPNFSIGAVLTMKFAAQAARYFESVEVVELHHPNKVDAPSGTATRTAQLIAAARAEAGCAPQPDATATALDGARGADVDGVPVHAIRLRGLLAHQEVLLGGEGETLTIRHDSLHHSSFMPGILLGVRRVTQNPGLTFGLENFLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV14</accession>
    <name>A0A0F4JV14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946043.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37990">
        <property type="protein sequence ID" value="KJY37990"/>
        <property type="gene ID" value="VR44_04460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.699"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8579" checksum="FFEB6A1309012403" modified="2015-06-24" version="1">MFRRREPVPFAFVAEADRFRSNVTPPPRESLSMTQITARSLVGLTVVAGLVGSLLFGMPALQPYKATGKAQQSEASQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV93</accession>
    <name>A0A0F4JV93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">VR44_05255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946175.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7107"/>
    <dbReference type="EnsemblBacteria" id="KJY37663">
        <property type="protein sequence ID" value="KJY37663"/>
        <property type="gene ID" value="VR44_05255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1685"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY37663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24326" checksum="4D09C96C62C77D59" modified="2015-06-24" version="1">MAVQINPSILSADFARLAEEARAVEGADWLHVDVMDNHFVPNLTLGVPVVESLSRATDTPLDLHLMIEDPDRWAPQYVEAGAGSVTFHAEAAAAPVRLAREIRALGARAAMALKPGTPIEQYEDILPELDMVLIMTVEPGFGGQSFLDIMLPKVRRTRELIAKHGLDLWLQVDGGVSATTIERVAEAGADVFVAGSAVYGAMDPAAAVRTLRDQAGAAIAAAPWACDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX93</accession>
    <name>A0A0F4JX93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946205.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37601">
        <property type="protein sequence ID" value="KJY37601"/>
        <property type="gene ID" value="VR44_05400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1716"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="800" mass="84567" checksum="9216479524A69304" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXV8</accession>
    <name>A0A0F4JXV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD</name>
        <name evidence="12" type="ORF">VR44_02005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945585.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39217">
        <property type="protein sequence ID" value="KJY39217"/>
        <property type="gene ID" value="VR44_02005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5807"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="77"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="23308" checksum="6046B04B03803F66" modified="2015-06-24" version="1">MLKVEVIHGRGVPLDASDVDTDQIIPAVWMKRVERTGFQDGLFQKWRRDPEFVLNRPERAGATVLVSGPNFGCGSSREHAPWALRDFGFKAVIAPSFADIFRNNLPNVGLVPVTLDAAATRKVMDAVTADATAEVTVDLLRATVTCEAAGVVAEPFFLDEGARYRLTRGLDLIDLAAEAEEAIGRHEASRPFWMPRTNGQVEDVFEDSGVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYH6</accession>
    <name>A0A0F4JYH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000049">
        <property type="protein sequence ID" value="KJY38798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945743.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38798">
        <property type="protein sequence ID" value="KJY38798"/>
        <property type="gene ID" value="VR44_02820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7294"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10558" checksum="A91F2622E6EA20F1" modified="2015-06-24" version="1">MRYKVTFLTGVAIGYVVGTAAGRERYEAMKKSARRVAQNPVVRNAAETAGQNGRAFAGKAVTAVGNKVGDVLPSSVARRVPGLRERGQGYEDEWGTSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZS2</accession>
    <name>A0A0F4JZS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000062">
        <property type="protein sequence ID" value="KJY38496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945862.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38496">
        <property type="protein sequence ID" value="KJY38496"/>
        <property type="gene ID" value="VR44_03485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7916"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471379" evidence="1">
        <location>
            <begin position="27"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="42473" checksum="6907FD2544D5B367" modified="2015-06-24" version="1">MTARWRGVAVGAAAVGLVVVPVGVGAGRAWDTAARPAVSATPVGDDFPRLTPAVAARLDAAVQKVLKEAGVPGVMVSLSAPGKGEYVRAFGVADEATGAPMKTDMSVRIGSVTKTFTVTALLRLVDQGKVGLDDPVGKYVAGVPNGERITLRQLAEMRSGLFNYSEDEGFFKALTSDPRRPFTPRELLSYAFKHPVLFEPGAKFSYCNTNLVLLGLVVEKVTGEPLRKVVTDQVIKPAGLRHTLFPTGAEFPSPHARGYTDQTATGKVEDAAGWDPSWGWAAGAMVSDLGDLRSWAGTLATGTLLTPATQAQRLKMVQALPDAGYGLGIFDVAGWIGHNGSLPGYEALVVHLPRPRATLVVLLNTDISYKGAEPSTAFGEAITRIVTPRHVFELPAQPVTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K008</accession>
    <name>A0A0F4K008_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ORF">VR44_00380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945290.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1044"/>
    <dbReference type="EnsemblBacteria" id="KJY39952">
        <property type="protein sequence ID" value="KJY39952"/>
        <property type="gene ID" value="VR44_00380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.74"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23483" checksum="0A9219661D07230B" modified="2015-06-24" version="1">MRIVLVGPPGAGKGTQAAFLAKNLSIPHISTGDLFRANISQGTELGVRAKAFMDAGELVPDEITIGMAKDRMEQPDAAGGFLLDGFPRNVAQAEALDEMLTGAGMKLDAVLDLEVEEDEVVKRIAGRRICRRDSAHVFHVIYAAPKVEGVCDKCEGELYQRDDDSEATVRNRLEVYHTQTEPIIDYYKSQGLLVTISALGEVHEITKRAMDALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0K9</accession>
    <name>A0A0F4K0K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_02810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000049">
        <property type="protein sequence ID" value="KJY38796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945741.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38796">
        <property type="protein sequence ID" value="KJY38796"/>
        <property type="gene ID" value="VR44_02810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7292"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="577" mass="62710" checksum="3793556BBBC9CC60" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0R9</accession>
    <name>A0A0F4K0R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945734.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38856">
        <property type="protein sequence ID" value="KJY38856"/>
        <property type="gene ID" value="VR44_02775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6797"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="36918" checksum="D0A2542653605843" modified="2015-06-24" version="1">MRVLVTGGAGFIGSHVVAVLAAGGHTPVVLDALLPTAHPDAPELPDAEFVRGDVRDAEAVGRALRGVDAVCHQAAMVGLGKDFADAPEYVACNDLGTAVLLAGMARAGVRRFVQAGSMVVYGEGRYECREHGVVRPGPRAVPDLEAGRFEPCCPRCGAELVPGLVDEDAPADPRNVYATTKLAQEHLAAAWARSSGGTAVSLRYHNVYGPGMPRDTPYAGVASFFRSALARGEAPRVFEDGAQRRDFVHVRDVARANAAALAGVEGLPDGGHRAYNVGSGDPHTVGEMAAALAAEHGGPAPVVTGEFRLGDVRHITADSARLRRELGWRPEVTFAEGMAEFARAGQRAPVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1R8</accession>
    <name>A0A0F4K1R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945255.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40059">
        <property type="protein sequence ID" value="KJY40059"/>
        <property type="gene ID" value="VR44_00055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.11"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="272"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY40059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="40376" checksum="D2E2A5B0341CD79B" modified="2015-06-24" version="1">MTAAARFALRGEDEDHEEEQLWALCEEAENLFADPPEQPRRHYELLGCAFEGELPSALGFLVLKPLDKHGTPLWEWYLEDARVLSSRPCARDLSRLDVTIEAVRSEQQPDYPQRVPLSVGFSLSDFDDRLLGHFRDLSEVLPVADPEPHPVRLLGCSLHGPLRDVVEGRRARRLAYRHLDALDTAGELLSIAGNPDVVGWEPSPRGPGLYDLTVHMDPQPPVVARIWPLWREGRPAVPNLWAPFDATGRARWLDPALHHRTGPDRPAGGTYHLDGRHVTDYEGFFCALGEAVNGPGGYFGRCLNGVSDALCGGFGATGPFTLVWHDHETARRCLGVQPLTFGPASFPELLSFLREKRIEVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K358</accession>
    <name>A0A0F4K358_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945445.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39596">
        <property type="protein sequence ID" value="KJY39596"/>
        <property type="gene ID" value="VR44_01235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2963"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471574" evidence="3">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25271" checksum="C3580D5D15295547" modified="2015-06-24" version="1">MKTSRVSLAAAFAAGAVLALSGTAFAHVSVQPGDAPKGGYATINFKVPNERDNASTTQLEVNFPVDQPLTSVMPQDIPGWTSTVEKTKLDKPLSVHGKQVNEVVTKVTWTGGKIEPGKFQQFPVSVGKLPENADKMVFKAIQTYDNNEVVRWIEESKEGAPEPQTPAPLLKLTAAKGGDGHDDAKPAADAKNAGKDADKDAKHDEAAATSGSDTTARALGIAGIVLGLGGVAFGIASRRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3C0</accession>
    <name>A0A0F4K3C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4768"/>
    <dbReference type="EnsemblBacteria" id="KJY39676">
        <property type="protein sequence ID" value="KJY39676"/>
        <property type="gene ID" value="VR44_00880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2886"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="33915" checksum="3B9D1012BF6696F4" modified="2015-06-24" version="1">MAAAKLAALSQADVSRETPIDPVSVQPEVEQATGATFAELPLDAITPNPKQPREVFDEDALAELVTSIQTVGLLQPVVVRQAAAPGRYELIMGERRWRACREAGLETIPAIIRATDDEKLLLDALLENLHRAQLNPLEEAAAYDQLLREFNCTHDQLADRIGRSRPQVSNTLRLLKLSPQVQRRVAAGVLSAGHARALLSVEDTEEQDRLAHRIVAEGLSVRAVEEIVALLGSEPSSTVKPKGPRAGGRVSPALSELATRLSDRFETRVKVDLGQKKGKITVEFASMEDLERILGTLAPGEDRVLEKGLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I204</accession>
    <name>A0A0F4I204_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001800">
        <property type="protein sequence ID" value="KJY16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16035">
        <property type="protein sequence ID" value="KJY16035"/>
        <property type="gene ID" value="VR44_40635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6994"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11115" checksum="89F777608DEB114B" modified="2015-06-24" version="1" fragment="single">MLPGTPARVAQGWAGLTGAPAVPPEWAMGYQHARWGFGSAAEVRRVVAGYAERGLALSAVHLDIDHYDGHRVFTVDGEAFPDLPGLAGELGAAGVRLVSIVDPAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3M6</accession>
    <name>A0A0F4I3M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001795">
        <property type="protein sequence ID" value="KJY16058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16058">
        <property type="protein sequence ID" value="KJY16058"/>
        <property type="gene ID" value="VR44_40620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469209" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="10206" checksum="EE5563E484A58BAD" modified="2015-06-24" version="1" fragment="single">PATVVTTPVGRTVATTVVAAATESAALVVTTGVGGTPAAVVVPTRREGTVAAPVVTTEGRAVATAEPTALVITTRVGGTAATVVVTAAVRGTVASAVVAAATETTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IC46</accession>
    <name>A0A0F4IC46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001546">
        <property type="protein sequence ID" value="KJY19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952439.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001546.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene727"/>
    <dbReference type="EnsemblBacteria" id="KJY19595">
        <property type="protein sequence ID" value="KJY19595"/>
        <property type="gene ID" value="VR44_39060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5573"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="30274" checksum="ED6EB8277EE452DA" modified="2015-06-24" version="1">MLIGLLTAVAASICYGTGSVLQAVGSRRAARLSPAAAGVTAHGGPNLTSTAKAAMTWEFIVGTILDFVGFGLGALAARLLPLFLSQTVISANLVITAVLSVKMLGIRLSRKEWTSIGVVCAALVLLATAAGHEGDHHAPMATHWWLLAVTLLIIVGGTAAVRFLGARAAILAGLLSGLAFGALGVGVRVLDGIDPFDLGTLLTDPALYAILVAGVGGMYLHTVALQIGSVNGATAALVVGETVLPGAIGVLWLGDASRPGLAWLAVAGFVLAVTGAVAVAWYGNHDGAEAPAQEQVPEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJX5</accession>
    <name>A0A0F4IJX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001425">
        <property type="protein sequence ID" value="KJY22312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952232.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22312">
        <property type="protein sequence ID" value="KJY22312"/>
        <property type="gene ID" value="VR44_37955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5155"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469875" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19023" checksum="CB1405BF5E8084E3" modified="2015-06-24" version="1">MRTRIAKIAAVAAAPLLAITLGAGTAHAGYGAGEIRFNGGYCLDVSGGNFVSGQKVQIWGCNGTSAQQWWLRTKDATHFEIQASQTYDPQGRLLCVNNWEGGDVTGNHMRLYPCDSGSAGDTQFNFVYAGNARQLQPRVASTNCINSWGGLSQGAEARLYPCSHSVEEDIVSYPSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IMU9</accession>
    <name>A0A0F4IMU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001395">
        <property type="protein sequence ID" value="KJY23365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952170.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001395.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23365">
        <property type="protein sequence ID" value="KJY23365"/>
        <property type="gene ID" value="VR44_37640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5033"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="644" mass="65872" checksum="9FD354AB1C9B5591" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP55</accession>
    <name>A0A0F4IP55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001355">
        <property type="protein sequence ID" value="KJY23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952090.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001355.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23812">
        <property type="protein sequence ID" value="KJY23812"/>
        <property type="gene ID" value="VR44_37185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4827"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="295" mass="30401" checksum="EF933F81468340F5" modified="2015-06-24" version="1" fragment="single">GWNGPTTGPAAVPGKSLVYVAQTMTNPGVAGVAEGVREAAAAIGWQVRVIDGGGTPAGIEAALSEAVALRPSGIVIGGFDPRLTAQQTRRAQAEGIPLVGWHAVASPGPSTEPPLFTNITTRVEEVAGISADWVIARSGGAGGVVVFTDDSIPFARTKAELIRRRLAGCPGVDLLASSNIPIPDAGQRVPQEVSSLLSRFRDRWTDSIAVNDLYFADAAPALRAAGRPGGGPPFNIGAGDGDPSAFQRINSRGFQAATVPEPLSQQGWQIVDEFNRAFAGRPASGYVAPVHVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPC8</accession>
    <name>A0A0F4IPC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001340">
        <property type="protein sequence ID" value="KJY23882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952054.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001340.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23882">
        <property type="protein sequence ID" value="KJY23882"/>
        <property type="gene ID" value="VR44_36995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4783"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470280" evidence="1">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="18810" checksum="F5088485C1FD271D" modified="2015-06-24" version="1">MVGGSQSRPPGAEMNTRTRVLTGTALAVVLGAGTFGAVSASATPAKKDEVKNNNFTTSTHLTIGAATRAAQAALEAAEKENQKVTVAVVDRNGNTIVTLRGDGAGPQSYESAQRKAFTAVSWNAPTSVLAGRLAQAPNLKDIPGTLFLAGAAPVQADGAPVAAVGVAGAPSGDLDEKFAKAGVEALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPX0</accession>
    <name>A0A0F4IPX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001304">
        <property type="protein sequence ID" value="KJY24047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951954.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24047">
        <property type="protein sequence ID" value="KJY24047"/>
        <property type="gene ID" value="VR44_36470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4594"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8201" checksum="7D1FC1273D84293C" modified="2015-06-24" version="1">MPTRRDPRGSFPVELLVFLAILTTGIILILVGHVSPEALAGYASALTGLYAAWHHHPRNEEPQRTPPQTPPTPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ67</accession>
    <name>A0A0F4IQ67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001283">
        <property type="protein sequence ID" value="KJY24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24142">
        <property type="protein sequence ID" value="KJY24142"/>
        <property type="gene ID" value="VR44_36215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4487"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="23879" checksum="365EE0EA2EF98883" modified="2015-06-24" version="1">MRDLPGATTPSSGRYGGWTALLVERCLFTGQGWSEAEDALRAAEATAGNDDERGAAACERGQLAYAATVLGVRDRADEARSALGRAAALLSAGSRTRPLLDFRRGLVAEHLADAPQAARPAYHRAHAGAEAHGDTLLLSFTWRHLAALALRDGEVAEARRGFTESLRIREELGFLVGTAPALAALAEAEPEPEASRLRAEARRLFHLLGGIPTWLADQLQPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQY7</accession>
    <name>A0A0F4IQY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001333">
        <property type="protein sequence ID" value="KJY23913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952034.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001333.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23913">
        <property type="protein sequence ID" value="KJY23913"/>
        <property type="gene ID" value="VR44_36880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="31000" checksum="E6FEDEF466A3C4FB" modified="2015-06-24" version="1" fragment="single">MNWLIHDYREGDLAAVVHLIDTTAELGQESVFSLAECISALTDRQPCVVAVHQGVPIGAALACVTGERAWVMRIAIAAGWRGRGLASALLVELERRLIAARVGRIAYVLPEEDLLGEGLLNAGYTRQPAVAYFEKTEPLHGPAAGLLDDLGGRFLPNDLWGKVAGMEKEKELIERRVVLPLAEPERAAAHGVRPPRAITLFGPPGTGKTTFARAIASRLGWPFVELLPSRLADGGNLAAALRQAFARIAELERVLVFIDEVEEIAPVRSEPAQPGGAHGVTNELLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRA1</accession>
    <name>A0A0F4IRA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001314">
        <property type="protein sequence ID" value="KJY23998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951984.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001314.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23998">
        <property type="protein sequence ID" value="KJY23998"/>
        <property type="gene ID" value="VR44_36630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4635"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="29292" checksum="8E158290FE7BF3AF" modified="2015-06-24" version="1">MTTSTSADATSVGPLLRAWRVRRGISQLELAGRADSSSRHISFIETGRSRPSEEMVLRLAGHLDVPVRERNALLLAAGYAPRYAHTPLDDPSMGALREGLERLLTGYEPYPALVVDGTYTVIAANRGIAMLLDGIPEHLLAPPLNAMRLTLHPEGLAPRIHNLREWRGHLLAQMERQIALARSAPLRALYEEVAAYPVTERPGDAEPDEPVPYIALPLRIEHEGQLLSFVSSISTFNTPMDVTVAELAIETFLPADPATVKYLRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISE2</accession>
    <name>A0A0F4ISE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">VR44_35475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="JZWV01001232">
        <property type="protein sequence ID" value="KJY24408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951767.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001232.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene198"/>
    <dbReference type="EnsemblBacteria" id="KJY24408">
        <property type="protein sequence ID" value="KJY24408"/>
        <property type="gene ID" value="VR44_35475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4209"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="28108" checksum="545D53CB21C40CA9" modified="2015-06-24" version="1">MADAPYKLILLRHGESEWNAKNLFTGWVDVNLNEKGEKEAVRGGELLKDAGLLPDVVHTSLQKRAIRTAQLALEAADRHWIPVHRSWRLNERHYGALQGKDKAQTLAEFGEEQFMLWRRSYDTPPPALEDGTEFSQSADPRYASIPPELRPRTECLKDVVVRMLPYWYDSIVPDLLDGHTVLVAAHGNSLRALVKHLDGISDADIAGLNIPTGIPLSYELDADFKPVTPGGTYLDPEAAAAAIEAVKNQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISW1</accession>
    <name>A0A0F4ISW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_37230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001359">
        <property type="protein sequence ID" value="KJY23796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952098.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001359.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23796">
        <property type="protein sequence ID" value="KJY23796"/>
        <property type="gene ID" value="VR44_37230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY23796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="35083" checksum="53DF5E9D321491A1" modified="2015-06-24" version="1" fragment="single">MPSSASGSAPGSPGGARRRPPTIADVARAASVSPTTVSHALNGLGKVDPRTRERIKRTAAELGYRPNLRAQRLRNGQAKAIALASSMPFAVAAGPSRLGFYMEIAAAAAERAMVHGYALVLVPPVQSGSPLHSLDIDGAIVVEPGEDDPAVAQLRERGLPYVALGREVARTDAPYVDLRGGPVTGLLLRHLREQGARRPALLIGAGRRHSSVDARAAYETAAAEEGWTPLVATAPEEGGEQAGYEACAALLAEHPRTDAVCALVDVFAVGAVRAIRDSGRRVPEDVLVVTRYDGPRARTCEPPLTAVDLHLDRAAADAVELLLSRLRDGGAAAGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV07</accession>
    <name>A0A0F4IV07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001217">
        <property type="protein sequence ID" value="KJY24501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24501">
        <property type="protein sequence ID" value="KJY24501"/>
        <property type="gene ID" value="VR44_35175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="11025" checksum="EBDEC9CEB746D2F3" modified="2015-06-24" version="1" fragment="single">MDEPAEIGRRVQRLRGERGLTQRQLAEPAYTPAYVSTLEAGKVRPSEAALRFLAGRLGTSYEELTTGRPASLGTELRLALTDAQRTLATGSAREAAGHFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVB7</accession>
    <name>A0A0F4IVB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001003">
        <property type="protein sequence ID" value="KJY25965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950966.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25965">
        <property type="protein sequence ID" value="KJY25965"/>
        <property type="gene ID" value="VR44_31130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2712"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="26805" checksum="AB3790C93A7B7376" modified="2015-06-24" version="1">MPLPSLLGVFAHPDDESLLAGGVLAQHHAAGARTAVVTATWAPDSRRAPELADALSVLGAGTPRLLGYGDARNPEAAPAQPRLLDAPLEEAVGRLVAHIRDFRPDVVVGHDALGQLTGHPDHVRTHQITLLAVEAAGLAHLYPDAGPPWQPSALYAFTHPESGVGLLGPLLEGVGKAVLAVPDTYVTTSVDVTPWAPVKWAAILAHRGEVARERALPGILSRLPEADRHQIIRTEHFTRLSPGPVPGARDRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVY8</accession>
    <name>A0A0F4IVY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-diaminobutyrate 4-aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001158">
        <property type="protein sequence ID" value="KJY24856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24856">
        <property type="protein sequence ID" value="KJY24856"/>
        <property type="gene ID" value="VR44_34170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3802"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="46005" checksum="EF29F90892FD50AB" modified="2015-06-24" version="1">MSLTEQAAAAAQIPPQGGRAPGAAEGILRRQALRESAARTYARSLPIVPVRARGLTIEGADGRRYLDCLSGAGTLALGHNHPVVLEAIRGVLDSGAPLHVLDLATPVKDAFTTELFANLPAGLASDARVQFCGPAGTDAVEAALKLVRAATGRSGLLAFAGAYHGMTAGALSASGGATDVRVTRLPYPQDYRCPFGIGGTEGARLSAAWTESLLDDPKGGVPAPAGMLVEPVQGEGGVHPAPDEWLRRMREITQTRGIPLIADEVQTGVGRTGAFWGVDHAGVVPDVMVLSKAIGGSLPLAVIVYRSELDVWEPGAHAGTFRGNQLAMAAGTATLAYVRRNGLAERAAELGGRMLAALRGLAADQPCVGDVRGRGLMLGVEIVDPDTGAAAPALAAAIRQGCLDRGLIVELGGRHGAVVRLLPPLTLTDEQATAVLDRLADAVPAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW24</accession>
    <name>A0A0F4IW24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001152">
        <property type="protein sequence ID" value="KJY24891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24891">
        <property type="protein sequence ID" value="KJY24891"/>
        <property type="gene ID" value="VR44_34045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3736"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="12737" checksum="00A0F3DA8158279F" modified="2015-06-24" version="1" fragment="single">KPQLVLKSGFPAYGVTGDPNAATDTCEPLVLGPQFGSYGATAADISVAFVSAAAAALGSDEMPTRRRRVAVRGTRGIGPKDMLLNSRVGAVDVDARSGLVSLDGEPLRSEAADSVSLNRLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX45</accession>
    <name>A0A0F4IX45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000995">
        <property type="protein sequence ID" value="KJY26013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26013">
        <property type="protein sequence ID" value="KJY26013"/>
        <property type="gene ID" value="VR44_31040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469901" evidence="2">
        <location>
            <begin position="31"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="444" mass="46353" checksum="F4C3B8A3783F8793" modified="2015-06-24" version="1" fragment="single">MRGVRGWFRALLLALAVTLTVAAPAGGAAAEPLPGVPSTASSPSHADGEGKLSRVKVKRRVDVRTLPRPKRIAEPQEQPHLAPPKRPAPVGPQRQPSLPVTGVALTPKGAAAPKAVPSTAVIEQLKTFRTLGNADNNAAARTAPSDTQLAVGPTHIVQFVNRSGQIYDKAGHAVGSPFDLGTFFGFTANTGGDPRVLYDAGSGRFFAAYEGLLTGGDEVDVAVSATSDPRGSWSVYIAGSNTSNVQHDRPKLGYTNDKVTLTWNNYDLAVAGKPFLGEQTVVVNKADLLAGGASVALTTFAQDKNKSEVVPATSLSGINDQFAMEHDRTDVIVTTITGVPGISPVNQTENTIAIGTASAPPMAAQPPGGDATINTNEDRMLSVAWQNNHLWGLFNVKCTPIGDTAEHSCQRFVQITTGGTQNLATNLDLGLVGGDLYCGSLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXI3</accession>
    <name>A0A0F4IXI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26717">
        <property type="protein sequence ID" value="KJY26717"/>
        <property type="gene ID" value="VR44_29370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2238"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="116"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="46967" checksum="6FB1958B5ADEAA89" modified="2015-06-24" version="1">MLIIHRNPLEPFPYRSWLPDHTGDIVVLANREKIELAGEKVPDGNLGYTRLEIHDDFDSPEFEARAVELMEEHRITGVTVLHEGDMDLAARLRQRFGLRGPWKDDVKPFRDKALMKTRAQASGIEVAAWVQPRTADEARNFAEAEGFPLVFKERSGFNAIGLRVLHDQASFEETLAEAYAAGERDDLLLEGFVPGRMCHVDGVVRDGRVAMAWPSQYQYDLSSFASDPGPRIDLTLDEDDPVTPRLLDLAERVLAALAPEGSRLRDHAFHMEVFLTPDDRLVLCEIACRPGGAKIREVFHSLFGVHLGEYAVRADAGHPLHEAVRKGDDPAGLPRPRHMAGQLLMMKRPGLVRELPAVPDEPWLDGFWLYAEEGQVIAPASGSSDFLAAAVGTAPDRTECERRLRELGEWVREHSVIGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY46</accession>
    <name>A0A0F4IY46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000923">
        <property type="protein sequence ID" value="KJY26584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950705.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000923.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26584">
        <property type="protein sequence ID" value="KJY26584"/>
        <property type="gene ID" value="VR44_29685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2314"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="39332" checksum="3A4C875D2292F71B" modified="2015-06-24" version="1">MSSPERTVPEHLVLDGVLTAEQAAETVAGILAVQRADGAIPWFRGHHLDPWDHTEAAMALDAAGEHEAAERAYAWLARHQNPDGSWYAAYADRPEGVDTAEPQDAGRESNFVAYIAVGVWHHYLATGDDTFLDRMWPAVVAAVEFVLGLQQPGGEIGWKREADGTAVTDALLTGSSSIHQALRCALAIADHRGDPQPDWELAAGALGHAIRRHPERFLDKSRYSMDWYYPVLGGALTGAEAKARVEERWEEFVVPDLGVRCVLPNPWVTGGESCELALTLWAMGESDRALEVLRSIGHLRAENGMYWTGYVFEDRAVWPVEQTTWTAGSLLLAVAALGGEEATTVVFGGERLPAGLDPGCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYA7</accession>
    <name>A0A0F4IYA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000878">
        <property type="protein sequence ID" value="KJY27015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000878.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27015">
        <property type="protein sequence ID" value="KJY27015"/>
        <property type="gene ID" value="VR44_28580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2045"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="206"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="414" mass="44693" checksum="5695D3BDBABBEC2F" modified="2015-06-24" version="1">MSRESLPALPGKPDRPELPGKLPDHLRAELIAFRRDLHMHPELGHQEFRTTAAIKARLEKAGLRPRVLKSGTGLICDVGTWDGGRPMLALRADIDALPIPDAKTHVPYRSTVPDRAHACGHDVHTSVVLGAGLVLAELDRQGLLPRPVRLLFQPAEEVLPGGATEAIDSGVLEGVGQMIAVHCDPRVDAGRIGLRSGPITSACDRLEVTLTGPGGHTARPHLTTDMVTAAARVAVDVPALLTRRMDARSGMSVTWGRIESGHACNVIPMHAELSGTVRCLDLNAWYEAPDMIYAAIDEVATMHGAKFEINHVRGVPPVVNDPVVTELLRESMAARRGIESVEDTEQSLGGEDFSWYLEHVPGAMARLGVRKPGDTAKRDLHRGDFDVDESAIEVGVEFFTAAALLDGRRSRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZF8</accession>
    <name>A0A0F4IZF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000838">
        <property type="protein sequence ID" value="KJY27410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950327.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000838.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27410">
        <property type="protein sequence ID" value="KJY27410"/>
        <property type="gene ID" value="VR44_27630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1761"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="30198" checksum="D7095672BBA83125" modified="2015-06-24" version="1">MTSPSHGTVLIASDLDRTLIYSSAALGLTMPDPQAPRLLCVEVHEGKPLSFMTETAAALLAALAADPAAVFVPTTTRTRKQYQRIRFPGPPAPYAICANGGQLLVDGEPDRDWRRAVARRLAEECAPLEEVHRHLLDTADPQWLRKARIAEDLFAYLVVERALVPAEWLKALTRWAEERGWTVSLQGRKIYAVPRPLTKSAAMREVARRTGATASLAAGDSLLDADLLLAADRAWRPGHGELADAGWTSPTVTALHEAGVLAGEEIVRSFGQAVATLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZR8</accession>
    <name>A0A0F4IZR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000974">
        <property type="protein sequence ID" value="KJY26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26176">
        <property type="protein sequence ID" value="KJY26176"/>
        <property type="gene ID" value="VR44_30715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2599"/>
    <dbReference type="eggNOG" id="ENOG5032EXW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12454" checksum="BA45A42397ECFB7F" modified="2015-06-24" version="1">MSRRSHGARPPGPHTNPQPGAPLPAPELTEGQCRRCGTHIAGLDGRYACGVCGWVNDHSEGHRRLPRADEDPDRPPAGRRRPRLLPGPQPGAEEPGNEPATGAGDEPGNEPGTGTRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZT9</accession>
    <name>A0A0F4IZT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950516.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26983">
        <property type="protein sequence ID" value="KJY26983"/>
        <property type="gene ID" value="VR44_28655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2062"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="24446" checksum="E4959A2FE60887F2" modified="2015-06-24" version="1">MAQHAPPARGARLGRAAGANGPESMVSGVVLLLPGASRIAPGPMRPLARALGRAGGAEGLVAHAVLHGPGDREAAARWAADEALRRYGDVPVCLAGYGAGGRAALRAAGHAAVNSVVALAPCLPDEVRGGSPEPVKQLAGRQVLIVHGTNDARSDPECSFLLAARAKKANRSTCRFEVHSDGHGLREHRAEVVALAVDFVLGAMVSGRYSRPVTDALAAPPPLGLRMPLASGFGRSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZU5</accession>
    <name>A0A0F4IZU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000972">
        <property type="protein sequence ID" value="KJY26201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950885.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000972.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26201">
        <property type="protein sequence ID" value="KJY26201"/>
        <property type="gene ID" value="VR44_30680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2591"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9515" checksum="152E451626323A6C" modified="2015-06-24" version="1">MAAAASIVMPKKKPLPAGLPREWYENHNRRLKAMRLAISLLDTGTYDAKRATNRKIRTMAVRVGIHRPSNLTCRMVRAFIVANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZU7</accession>
    <name>A0A0F4IZU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000862">
        <property type="protein sequence ID" value="KJY27179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950444.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000862.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27179">
        <property type="protein sequence ID" value="KJY27179"/>
        <property type="gene ID" value="VR44_28280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1900"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00664">
        <property type="entry name" value="VINCULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="3">
        <location>
            <begin position="51"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="33694" checksum="438CA4B1807BAFF0" modified="2015-06-24" version="1">MDQSLTTALLDDLCTLLRKPLPERTEIRVWGMSGVERVTFPGGTTAVFKYAKEPFDREAQALRIAHQRGLPVPELHATAVRDHWLGMLMDDLGTPVREADDVDGATAAVLLHRARPATGLPLLDGNGLVSLPSRALDHLQRLRKAERWTNCEDVEAALRTISAAAASRARGATLDPFGWVHSEFHPTSVHIGENGRHLLDFARAFTGPGLIDLASYHGTTDTPDPVRLRVLLEQYVTAGGHEDALASRGGLTAEAWALGWHRMWAVEWFMEQAIRWINDPTRDFAYIPVVQRHLNDVVRFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZV1</accession>
    <name>A0A0F4IZV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000822">
        <property type="protein sequence ID" value="KJY27545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27545">
        <property type="protein sequence ID" value="KJY27545"/>
        <property type="gene ID" value="VR44_27300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="367" mass="35541" checksum="2483247B685FB8C0" modified="2015-06-24" version="1" fragment="single">MAQPGPVEDLAAARCGAGSPGDEGAEVDRAVRLVGEVGAEAARQQDGREEAGVEHVEEFAGAAQPDAHLVGGLVVDEFQVGFAEGGPAAVGADLVGDEEGVEVGVEPADGADLGGACAGAQGAPDLPGHLGGGVRGEGVEEAAGEAAPAAVHLVDAEPARSGVALEEVRVAERACEGPVGQPVAEALEQVGGQDDLVGSVGVAVDGVPDGCHGLGAQVRQCGGPGGEGVGGVEGGEPAGGLPGVGDLAAELPGVRAGVRAAAAGAVAGDEPVADDPAQEVSEVEEFRQCGDLAERLVVAGVEEAFEVDGARGDDVLGDRAERGGHGRDGAPGGGQRLGPSPGQAGQQGGAVRSGGVGERRGHPVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0L3</accession>
    <name>A0A0F4J0L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000852">
        <property type="protein sequence ID" value="KJY27278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950393.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000852.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27278">
        <property type="protein sequence ID" value="KJY27278"/>
        <property type="gene ID" value="VR44_27980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1846"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470456" evidence="1">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25526" checksum="3E1A5974CC62B98B" modified="2015-06-24" version="1">MVNRRKRVVVAAAVAGALLVAGGGVWAASALAGADRSAPTAYWVEAGGKLPSAENAAPVPPNELTGKLLPVPSGFEPGPDLGGDGNDYFASGEKAAETFKEARKGLSNSDRKKRDDMLADLKLKGLAARTYASGGGSMVVEIRLMQADPKAVGAFSEVSKKLLDLTGDDRDAPKVDGYPDAKCSLLAVGEHNKEKLDSLYCVAVQGDVLVSLRAYGPKEQGLSKLEATGFLKNQLSRLKSPGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0X6</accession>
    <name>A0A0F4J0X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950114.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000784.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000005_gene3921"/>
    <dbReference type="EnsemblBacteria" id="KJY27920">
        <property type="protein sequence ID" value="KJY27920"/>
        <property type="gene ID" value="VR44_26465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1477"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14527" checksum="3C44783EDE97F022" modified="2015-06-24" version="1">MSVVLGYDESPGAERALRVALEVATAFGEPLVLVYGAAAPGSAGEEYRAHREAVLQAGRSALARAVEAADEAGVPSTVEVMDDKPAQALLTAAQHHHARVIIVGTWGDSPIRGALLGSTPHKLLHLSPVPVLCVPTEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J142</accession>
    <name>A0A0F4J142_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000914">
        <property type="protein sequence ID" value="KJY26646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950681.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000914.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26646">
        <property type="protein sequence ID" value="KJY26646"/>
        <property type="gene ID" value="VR44_29560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2288"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470301" evidence="2">
        <location>
            <begin position="31"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="20856" checksum="B71358D00F6128FF" modified="2015-06-24" version="1">MKARIATAAIAVTVLAAGSAAVITVATASASETADVAVSVQAATVAAKPAVTVAAGPDATVAAEPNATVAAKPAGSPLAPQASGTTAPPPGGTTTPPPKPGKSTTASPQPGKPGETYKGSATFYSPGLGACGKVVTESDLAVALDPTMFGPGYPSSNCGRKVVITYKGKSVTATVLDEAPGAGRYGLDLTPGAFKALAPLDKHKLDVTWRFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1D9</accession>
    <name>A0A0F4J1D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000807">
        <property type="protein sequence ID" value="KJY27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27684">
        <property type="protein sequence ID" value="KJY27684"/>
        <property type="gene ID" value="VR44_27015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1565"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17960" checksum="1F7A0090F95FDEC4" modified="2015-06-24" version="1">MGPLLRSVTDADRFGVVTVEGTEAPMRLRTTAAALAGALALVLPAGAQAFADDGKALNYVYVDQSHAEKNAQIKDTGADKCHALPSAASDVVEAVNETDSVALIFAEEECGGEPVATLQPGEKAGDFHAASVVFQQAHRQDQQQADQQQKPEQKPEQQDDYDSFDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J211</accession>
    <name>A0A0F4J211_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950176.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27778">
        <property type="protein sequence ID" value="KJY27778"/>
        <property type="gene ID" value="VR44_26785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1515"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32221" checksum="D6D3323C825D906D" modified="2015-06-24" version="1">MTVEKPYVVQPAAGVYAYVQPDGGWCLNNAGWVCDGGQTLLVDTAATERRALALREAVLAAGAPLPRTVVNTHHHGDHTYGNAVFAPALIVGHDNARAEQLAAGHQLELIWPATDFGAIEITAPDLTYGDRLTLHVGETEVRVLHPGVAHTTGDSVVWLPGRRVVFTGDLVFAGGTPFLAMGSLAGSLRALELLRSLDAETVVPGHGPLTDPSAYESTERYLRYVAELAREGREKGLTPLETARGADLGEFAAWRESERLVANLHRAYAELAGEPEGAPLDIMAVLRDMTVMNGGTPILCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J241</accession>
    <name>A0A0F4J241_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000794">
        <property type="protein sequence ID" value="KJY27818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4832"/>
    <dbReference type="EnsemblBacteria" id="KJY27818">
        <property type="protein sequence ID" value="KJY27818"/>
        <property type="gene ID" value="VR44_26700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1499"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9498" checksum="DB45E282C826DB64" modified="2015-06-24" version="1" fragment="single">RVAIARALVGERRLVLADEPTGALDSETGESVLALLRLRCDAGAAGILVTHEPRFAAWADRVVFLRDGSVVDETLRSNADSLLSGRAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2Q3</accession>
    <name>A0A0F4J2Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SpoOJ or ParA or ParB or repB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949832.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000714.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28612">
        <property type="protein sequence ID" value="KJY28612"/>
        <property type="gene ID" value="VR44_24960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1080"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="423" mass="45825" checksum="004FAFE444D91813" modified="2015-06-24" version="1">MTTPGNAEHGLRLTPFHGLRYVPERVGSLAAVTSPPYDVVVRPDGVDYLESADPHNIVRLILPQAGTPAARNEQAARTLSDWLAEGVLSADPQPALYVYEQRRAGLLQRGIIGALALSAAEDGIVLPHEDVMPDVVTDRAGLMRATSANLEPLLLTYRGDGPGAGADAVVEATAAREPLLSTVTEDGFRHSLWAVTDPAELAVVTSDLAHRQALIADGHHRWATYLRLQEEHGSPTPWDFGLVLLVDTVRYPLQVRAIHRMLRRLPLSEALAKAEGSFRIRPVEGPLPLALEALADASERGNAFLLTGDGTFHLVTDPDPALIERTVRRDRPEAWRRLDATVLHASLLDALWQVPDAPDHIAYIHDAAATVAMAERHGGTAVLLHPVREEVVRDLARQGVTMPRKSTSFGPKPATGLVLRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3T7</accession>
    <name>A0A0F4J3T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949693.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28920">
        <property type="protein sequence ID" value="KJY28920"/>
        <property type="gene ID" value="VR44_24195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="87"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="49602" checksum="0622FAEAA85D13A8" modified="2015-06-24" version="1">MSLRSRVSTPDDRHSPREDGRLVSTYRAKLLEEIDLAEMSALAPAERRARLERVLGHIISREGPVLSTAERAQLIRRVVDEALGLGVLEPLLEDASISEIMVNGPDQIFVERAGRVEQLPIRFASHEQLMQTIERIVSTVNRRVDEANPMVDARLPSGERVNVIIPPLSLTGATLTIRRFPRAFTLQEMIALGSLDEQMLLLLSGMVQARMNLIVSGATGTGKTTLLNALSGLIPEGERVITIEDSAELQLQQAHVIRLESRPANVEGKGQITIRDLVRNSLRMRPDRIIVGEVRGGETLDMLQAMSTGHDGSLATVHANSSQDALMRLQTLASMSEVEIPFEALQDQINSAVNVIVQLTRFGDGSRRITEISVLDSHGREPFRITTVCRYVAQPMAADGRVHGYFAYAPLPRRIAERLYMNNQPIPQAFGVAPPEDHLDPLTSPRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4R1</accession>
    <name>A0A0F4J4R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="12" type="ORF">VR44_23135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000651">
        <property type="protein sequence ID" value="KJY29352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949496.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7544"/>
    <dbReference type="EnsemblBacteria" id="KJY29352">
        <property type="protein sequence ID" value="KJY29352"/>
        <property type="gene ID" value="VR44_23135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.566"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="187"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY29352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="504" mass="54252" checksum="E51CDFBD527DC420" modified="2015-06-24" version="1">MPERRTVALVTLGCARNEVDSEELAGRLAADGWELVEDAADADVAVVNTCGFVEAAKKDSVDALLEANDLKDHGRTQAVVAVGCMAERYGKELAEALPEADGVLGFDDYADISSRLQTILSGGNVEAHAPRDRRQLLPISPAERQGASVALPGHAQEAAEAPAEAPADLPEGVAPASGPRAPLRRRLDKSPVASVKLASGCDRRCSFCAIPSFRGSFISRRPSDVLGETRWLAEQGVKEIMLVSENNTSYGKDLGDIRLLETLLPELAAVDGIERVRVSYLQPAEMRPGLIDVLTSTPKVAPYFDLSFQHSAPDVLRAMRRFGDTDRFLELLDTIRSKAPQAGVRSNFIVGFPGETEEDFAELERFLTHARLDAIGVFGYSDEDGTEAATYENKLDEETVAERLAHMQRLAEELTSQRAEERIGETLEVLVETVVPFDEAEEGEGAYGRAAHQAPETDGQVVFTDGTGLVPGRIVTAKVVGTLGVDLVAEPLGTEFSEIQEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5D7</accession>
    <name>A0A0F4J5D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949632.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000681.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29049">
        <property type="protein sequence ID" value="KJY29049"/>
        <property type="gene ID" value="VR44_23875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.748"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="117"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="33938" checksum="58D1E5C2DF314790" modified="2015-06-24" version="1">MTAPLRCAVLDDFQGAATTLADWSPVTARGVEVVSYPDHLADEDALAARLAGYDILVTLRERVPFPASLLERLPRLKLLVASGMRNSVIDYAAAGRAGVTVCGTASSSTPPVELTWALLLGLARGIVTENTALREGGPWQQTVGADLHGRRLGLLGLGKTGSRVARIGLAFGMEVTAWSQNLTKERAEAEGATLAPSKEALLAGSDFVSVHLALGERTRGLIGAAELALMRPTAYLVNTSRSAIVDQEALLEALRNGRIAGAGLDVFDTEPLPAGHPLRTAPNLLATPHLGYVTRANYATYYGEAVEDVLAFLDGAPVRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5H2</accession>
    <name>A0A0F4J5H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000684">
        <property type="protein sequence ID" value="KJY29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949649.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000684.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29013">
        <property type="protein sequence ID" value="KJY29013"/>
        <property type="gene ID" value="VR44_23975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.772"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470402" evidence="1">
        <location>
            <begin position="36"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="61"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="34848" checksum="16E2A7029EBCAA5C" modified="2015-06-24" version="1">MPRFRAAPRPLVALALLLSLTACGGPSGEQRPASGAQSAPGFPYIVTNCGVSSTYQAPPRRAVTLNQHTTEIMLALGLQDRMAGTAYLDDSVLPAYRGAYEGIEVLAKEYPSKEVLLAADPDFVYGGYSSAFDKGQGRDREALAKAGIGSRLSIEYCTAGRVGLDQLKTEITEVARTFGVPGRGAALIADEQRRIDAVTARVKDEARPSVFVYDSGEASAFTSGGNGIGNEIVSLAGGTNVFADLQDTFGDVSWEKVIERKPEVVLIYDYGGTAVETKKQRLLNDPALAEVPAVKNRRFAVLPLSSAVLGVRVADAVESLGRQLHPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5W0</accession>
    <name>A0A0F4J5W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000741">
        <property type="protein sequence ID" value="KJY28311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28311">
        <property type="protein sequence ID" value="KJY28311"/>
        <property type="gene ID" value="VR44_25595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1218"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="15125" checksum="41F503E869148E54" modified="2015-06-24" version="1" fragment="single">PPLTPATAEARLRCAVWWDTVPGAGAFHLEASTDGTTWQPVPFSTVRTTGGTPEQWPEGSAGGWSGRIWHRLEAPLTPWAGRQVRLRFRHTATGRYVGRGVYVDVIRVSEPRALLFSEDRPADAARLETTGWTRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Y5</accession>
    <name>A0A0F4J5Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949949.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28336">
        <property type="protein sequence ID" value="KJY28336"/>
        <property type="gene ID" value="VR44_25555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1210"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470621" evidence="1">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="86"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="518" mass="54842" checksum="E4717A5B2648BA85" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J625</accession>
    <name>A0A0F4J625_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-aminoethylphosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949287.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29812">
        <property type="protein sequence ID" value="KJY29812"/>
        <property type="gene ID" value="VR44_21995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.279"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470759" evidence="2">
        <location>
            <begin position="28"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="37952" checksum="B607C13E1B58C1D0" modified="2015-06-24" version="1">MSRALLLRTATALTTGLALAGTLTACGGSSTADGSGAQGGGKTVTVYSADGLKSDKGDGWYDKVFADFTKKTGIEVKYVEGGSGEMVQRAVREKTNTQADVLITLPPFIQQADGKGLLQAYAPQGSDHVNGADKSPDAKWTSVVGNYFGFVYNKKELTSAPRTWEELLDAKYKGKLQYSTPGVAGDGTAVLVKAMHDFGGKDQAMDFLKKLQANNVGPSSSTSKLAPKTDKGELLVANGDVQMNFAQSKSMPNLGIWFPAKDGGKPTTFALPYAAGLVAKAPHTENGKKLLDHLLSEDAQKLVSEVGGGFPVRSDVKPTDANAIELTKLMGGVEVFEPDWADLDKNLTGYVDAWKSATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J678</accession>
    <name>A0A0F4J678_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949270.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29867">
        <property type="protein sequence ID" value="KJY29867"/>
        <property type="gene ID" value="VR44_21900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.260"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="52"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="539" mass="56801" checksum="CB5067A58CA158FF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J689</accession>
    <name>A0A0F4J689_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000622">
        <property type="protein sequence ID" value="KJY29715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000622.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5176"/>
    <dbReference type="EnsemblBacteria" id="KJY29715">
        <property type="protein sequence ID" value="KJY29715"/>
        <property type="gene ID" value="VR44_22220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.329"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="20006" checksum="38C06021854AAEAC" modified="2015-06-24" version="1">MTTSASLPAHPTPTASGGDSVTDRLVAANRRYASAFTDPGMDARPVLHVAVVACMDARLDLHKALGLELGDCHTIRNAGGVVTDDTIRSLTISQRALGTRSVILIHHTGCGLESLTEDFRHELEDEVGQRPAWAVEAFRDVDQDVRQSMQRVRTNPFLLHKDDVRGFVFDVHTGLLREIDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W1</accession>
    <name>A0A0F4J6W1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_21630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000604">
        <property type="protein sequence ID" value="KJY29925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949219.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000604.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2210"/>
    <dbReference type="EnsemblBacteria" id="KJY29925">
        <property type="protein sequence ID" value="KJY29925"/>
        <property type="gene ID" value="VR44_21630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.204"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="36659" checksum="0C716E7D838B7140" modified="2015-06-24" version="1">MATRAVARRQSTSSARAAGGEIVDRDLVGMYLDEIARTPLLDAAREVELSQIIEAGVYARQLLDGEVERDGETPPREELEALAAEGERAKEVFIRSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYTKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRIQREFNRENGRDPEHAEIAAELDTTEKRVGDVLDWARDPVSLNMSVDDEGDTQFGDLLEDTAAISPEQSVLALLRSEELEDLLGKLDQRTASIIKMRYGIEDGRERTLTEVGKQHGLTRERIRQIEKHALLELKRMARDTGFDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J772</accession>
    <name>A0A0F4J772_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29659">
        <property type="protein sequence ID" value="KJY29659"/>
        <property type="gene ID" value="VR44_22415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.372"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470658" evidence="2">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="27929" checksum="992354EEF8D5D716" modified="2015-06-24" version="1">MFLIPATATAGPQRTAAAPHAATAAATAASVDDYYAPAAGKTGAALKAALHDIIKNQSTVTYDGVWNALKVTDQDPANPNNVILVYSGRSQSKNSNGGGVDDWNREHVWAKSHGDFGTATGPGTDLHHLRPEDVTVNSTRGNKDFDMGGSPVAQAPGSYTDADSFEPRDAVKGDVARMLLYMAVRYEGGDGFPDLEMDDKVNNGTAPLFGRISLLKQWNQMDPPDAFERRRNQVIFDTYQHNRNPFIDHPEWVNSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Q2</accession>
    <name>A0A0F4J7Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000688">
        <property type="protein sequence ID" value="KJY28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949666.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000688.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28961">
        <property type="protein sequence ID" value="KJY28961"/>
        <property type="gene ID" value="VR44_24055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.803"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14559" checksum="91DEBF6494EBD102" modified="2015-06-24" version="1">MALKWQGWVVGLVGLAGLLVFAPLGLYVWASSPARPAAATVPPPEVRVTDCRIDPASRRVLAAVEARGGQGSYVATVEFRDRRPSAADARTSRSLVRLPGLTPDTPPARTEAIGPVWPPATAPWCGVAEVVREGAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J808</accession>
    <name>A0A0F4J808_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PGA biosynthesis protein CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000606">
        <property type="protein sequence ID" value="KJY29903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29903">
        <property type="protein sequence ID" value="KJY29903"/>
        <property type="gene ID" value="VR44_21680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.214"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="40895" checksum="98BE846D83BDBA97" modified="2015-06-24" version="1">MLGGTGGGAAASGGGSGRSFSVAAAGDILIHPQLTDQAARDARAAGHTGYDFDRIMAGVKPVISKADLGICHMEPVLGEPGGPFQTYPDFLVPPQIAKTVKNIGYDTCSTASNHTLDHGPEGVQRTLDTLDREGLRHTGSARSQQEADRPNILDVKGVKVAQLSFASGFNGHEVPGDKPWLANLVSVKAVAAAEKRARAAGAEVVILSVHWGREHQSDPSGPQRELARAIARDTGVDLVIGHHAHVVQPMEKIDGTWVAYGLGNQLARHDVPSGLTEEGAIGWFDFTEKSGKWEVAARFVPTYTDIPPDPESTPGTDLPGTGPAPARDHRLVDVAAALASGTMPDGKKLLPEQRARYRLAFERTRGTLLNRGAAKDGLRPLRELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8K5</accession>
    <name>A0A0F4J8K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000543">
        <property type="protein sequence ID" value="KJY30727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948852.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000543.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30727">
        <property type="protein sequence ID" value="KJY30727"/>
        <property type="gene ID" value="VR44_19640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8539"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19357" checksum="EB53AE6DD5EC8CE1" modified="2015-06-24" version="1">MTNTPTPAPFSRIKIRTGALVFCGDDVALIRRDRADSTHYTPPGGNVEDGEDLDAALARELAEELRLDTTLAEGGDLLWVVDQRVTRPGPTPPPRKLHLIYRFHISPDVRATLAEQELDELPDGSHEVGVIEWIDYRKTAELPVFPPIGPALAALASPRAAVASAALDAVTDANYTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8N7</accession>
    <name>A0A0F4J8N7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_23295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000655">
        <property type="protein sequence ID" value="KJY29321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M04.017"/>
    <dbReference type="EnsemblBacteria" id="KJY29321">
        <property type="protein sequence ID" value="KJY29321"/>
        <property type="gene ID" value="VR44_23295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023062037" description="Neutral metalloproteinase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="10">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="226"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="413" mass="42044" checksum="43FE6F1D4B7DD85F" modified="2015-06-24" version="1" fragment="single">MSPTPQRRATAAGALVAAAALVAVGMQAGTATAAADATASQARTAAQPNPGAANLVLSASERATLISEANSTTAQAAKALGLGSGEKLVVRDVAKDADGTTHTTYERTYDGLPVLGGDLTVHAKGGVTKSVTKATQHEIKVADTNATVSTAAAEGQAVSAANSAGSKQSKADKGARKVIWAGSGVPVLAFETVVGGLQDDGTPSRLHVITDAKTGAKITQWQAVETGTGNTQYSGQVTLGTTQSGSSYTLTDGGRGGHKTYNLNGGSSGTGTLFSNSTDTWGNGLPSNKETAGADAAYGAQLTWDYYKTVHGRNGLRNDGVAPYSRVHYGNAYVNAFWDDSCFCMTYGDGTANNKPLTSIDVAAHEMTHGLTSVTGNMTYSGESGGLNEATSDIMAAAVEFWANNPSDVGDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J958</accession>
    <name>A0A0F4J958_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948861.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000544.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30720">
        <property type="protein sequence ID" value="KJY30720"/>
        <property type="gene ID" value="VR44_19705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8559"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17296" checksum="33B7B339E3034F08" modified="2015-06-24" version="1">MTATPSGNEHETDEQRRERERKEREKDKGGFSRAGRLSDGFSGHWPDLFIKTVENPSAETYTGTVTVTDCTPDEPERPASPASQSVTVAPGDSAEASFSLPSDVPADHPRLICSTLSNGGGVTDEGTDTIDLGGGVSPSPDSSPPEPNPNPDSTPPDTDSSEDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J971</accession>
    <name>A0A0F4J971_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000574">
        <property type="protein sequence ID" value="KJY30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30303">
        <property type="protein sequence ID" value="KJY30303"/>
        <property type="gene ID" value="VR44_20790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8877"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6556" checksum="D8433B0D427FD23C" modified="2015-06-24" version="1">MITIEIRGLEPAAVKAAEQISALFSATVPAPPCRTRGEDEVLVRIQADIGRTPGAGGYTDTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA46</accession>
    <name>A0A0F4JA46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_18960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948727.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3402"/>
    <dbReference type="EnsemblBacteria" id="KJY31055">
        <property type="protein sequence ID" value="KJY31055"/>
        <property type="gene ID" value="VR44_18960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8395"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="26660" checksum="51040CB1F2FA3AA6" modified="2015-06-24" version="1" fragment="single">LLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA89</accession>
    <name>A0A0F4JA89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">VR44_21725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949238.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene135"/>
    <dbReference type="EnsemblBacteria" id="KJY29891">
        <property type="protein sequence ID" value="KJY29891"/>
        <property type="gene ID" value="VR44_21725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.225"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="35369" checksum="803F60190E026F0A" modified="2015-06-24" version="1">MTGPLQLLNTAEELHKLPRTGRRAVVMTMGALHEGHATLVRTAREQAGPDGQVVVTVFVNPLQFGANEDLDRYPRTLDADLAIAEAAGADAVFAPSVDEVYPGGDPQVRITAGPMGERLEGATRPGHFDGMLTVVAKLLHLTRPDLALFGQKDAQQLALIRRMVTDLNFPVEVAGVPTVREDDGLALSSRNRYLSPAERPVALALSRALFAGRDRLAAQAALRARAEAAPASDERATALARLGEIRASADAHAVSAAVTGAAGLPDAVRAAARHVLEEAGRHEPPLVLDYLALVDPQDFTEVGPDFTGQAVLAVAAKVGTTRLIDNIPLEFGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAL2</accession>
    <name>A0A0F4JAL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31412">
        <property type="protein sequence ID" value="KJY31412"/>
        <property type="gene ID" value="VR44_18175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="20508" checksum="8E2081CF08F40930" modified="2015-06-24" version="1">MNIAAAADRLTRDLPCHRVEILQGRLTATPHDDGTHALILTRLTEAFHGAGARTAGLRTLQALGLWLPSGPEDYAVPDFSVVEQTFMESEPREHCYAPDAFRMVLEVTGDHWSDDLAIKAACYAQAGIPVYLVADRHHDEVVLHADPEAGKYLTRETYKRGTPLRLPESVGVSLTLPADRLLDGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB99</accession>
    <name>A0A0F4JB99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000478">
        <property type="protein sequence ID" value="KJY31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31642">
        <property type="protein sequence ID" value="KJY31642"/>
        <property type="gene ID" value="VR44_17700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8036"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="90"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26285" checksum="9A193A6818082051" modified="2015-06-24" version="1">MLGPLRITGTAASAHGPRTAAVAALLHLRPGRGTDYLCQAMDPVNPWSTRTLHSRLSELRNVLGLTHDGLPLLPRPKNGAGYVLHPSVTSDWAEFKILASRGLAAGPGAGTADLEAAMALVRGRPFEGRTLPWADPVIQEMHSRITDTAHTLARWHTDSDTPDLDAARRTVLQALEVEETSEVLYRDLLHIEAAAGNQAAVRKTVARAQQMARTYDITLDDTTEQTITEALTTTSPRLSQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBE2</accession>
    <name>A0A0F4JBE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948729.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3404"/>
    <dbReference type="EnsemblBacteria" id="KJY31058">
        <property type="protein sequence ID" value="KJY31058"/>
        <property type="gene ID" value="VR44_18975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8399"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="479"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="706" mass="77269" checksum="F646C91D830AFC96" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBX5</accession>
    <name>A0A0F4JBX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948653.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31248">
        <property type="protein sequence ID" value="KJY31248"/>
        <property type="gene ID" value="VR44_18570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8309"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24413" checksum="16A18F8094D68746" modified="2015-06-24" version="1">MEETIGVTETAPIPQQRGELLLDHAVRYVEERHWDVFAGTWLEPGDGRELCSCGVADCPAPGAHPAVKDWRSLASGSAVGVRRIWGKHPGASILLPTGRTFDALDVPDSAGFLALARLERMQRTLGPVTLTPDHRMLFFVLPGAGAKVPDLVRKLGWLPHALDLTARGEGEYVAAPPTRYGGKGPVQWARKPTPANRWLPDTEELIDALAYACGSEAAAARGRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCG9</accession>
    <name>A0A0F4JCG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000446">
        <property type="protein sequence ID" value="KJY32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948326.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000446.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32042">
        <property type="protein sequence ID" value="KJY32042"/>
        <property type="gene ID" value="VR44_16835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7802"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043746">
        <property type="entry name" value="DUF5691"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18944">
        <property type="entry name" value="DUF5691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="42348" checksum="42E6ECD2DAFEE5FC" modified="2015-06-24" version="1" fragment="single">AALVPALLDAARARTDLRPQALALAGARGLWLARLNPEWRFALRGAAGGTGELPDPADGEAVTRLWEEGLFAERVALLGAVRARDAAAATRLLGTTWATERAEDRLMFLDSLRTGLSMADEPFLEAALGDRSRNVRATAAELLSALPESALAGRMAERALACVGPDAVEPPAECDAGMLRDGVVERPPAGRGERAWWLGQVVDAAPLSCWRDRFGGLDPAEIVALPVAGGWAEEIHAAWCRAAVRQGDAEWSKALLGAASAPPAAGPGTASLAERAKLLETLPEGERAEWVAEFVRAHGLSEAFQLLGVCRVPWAGALGRAVVDALDAARVAGGYPWSFSGVMGLAERCLDPAEAGRLEVLTAGVAGLPEGGSGASAYWAEAFQRLLATLRLRAAMLTELTPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDL8</accession>
    <name>A0A0F4JDL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000413">
        <property type="protein sequence ID" value="KJY32422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32422">
        <property type="protein sequence ID" value="KJY32422"/>
        <property type="gene ID" value="VR44_16020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8723" checksum="AC36924A46E2C406" modified="2015-06-24" version="1" fragment="single">MPEDLDAAASRRIDTDPDPAACAELLAAAFVREPAVSWICGGAHSARARWFRATLRTHAGLAGARRTALVDPDGRLLAAAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEA7</accession>
    <name>A0A0F4JEA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948057.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32687">
        <property type="protein sequence ID" value="KJY32687"/>
        <property type="gene ID" value="VR44_15435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7488"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14843" checksum="CDC71F21E3D89CBB" modified="2015-06-24" version="1">MPDTTTASPEARKRLVSGPGLLLVWLYGVMVVGAVSRSAYQISTEFDRAPLAYSLSAAAALVYAFITYSLVRGGDRARRAALVCCGAELAGVLAVGTWTLIRPEAFPDATVWSDFGMGYLFIPVVLPVTGMLWLRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEK6</accession>
    <name>A0A0F4JEK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948573.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31411">
        <property type="protein sequence ID" value="KJY31411"/>
        <property type="gene ID" value="VR44_18170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8181"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470650" evidence="1">
        <location>
            <begin position="27"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="23375" checksum="B28FADB180A169AF" modified="2015-06-24" version="1">MWRTRVFVAAVAALSLGVGGGGAAQAAVGLPPVVAHVPTSEKVVFITIDDGWTHDAEAARMLVERRVPASLFLLPGATDYDTAYFTGLVGTGRVAVENHTVNHPDLTTLDAAGKDAEVCGAGERLEAAFGKAPKLLRPPYGVVNDEVRLAAKACGVKALVTWTYDFTTWSQTPPAPELRPGDIVLLHFTPTLAADLERALGAARAAGLKPAPLMPYLRSAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEV4</accession>
    <name>A0A0F4JEV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000396">
        <property type="protein sequence ID" value="KJY32730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948036.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000396.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32730">
        <property type="protein sequence ID" value="KJY32730"/>
        <property type="gene ID" value="VR44_15335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7469"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18850" checksum="1A664B70D5B558AA" modified="2015-06-24" version="1">MIEIRDAGAADGDALGEIHAAAWGAAYGPFFTPEFAAAGIADRRTRWHGRAAYGPGTVLLALAGGRPLALSWYRASDARPPGAAEILSFYAHPDGWGTGVSAALMTGTLARLRTDGFTTAHLWTLRDTPRSRRFYAKSGFAETGASRPCDFGDGRPLEQVEYERDCGDDGPRELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEY7</accession>
    <name>A0A0F4JEY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32912">
        <property type="protein sequence ID" value="KJY32912"/>
        <property type="gene ID" value="VR44_15025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7424"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="17434" checksum="E5EC1B57ABBD56F4" modified="2015-06-24" version="1">MRHDGFTVELHSAAPPDAVFGAFADPAVRRRWFRMPGREVSYDHDFTVNGGENASSVFTVEGAAPERLAYASRYLDIVSGSRIVYTYTARVDGEVRWASLVTVELRPDADGTHLRWTEQAAFLTPSSRPEHDLPHLRGATRLRLNGLAAALRPDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGC8</accession>
    <name>A0A0F4JGC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4031 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947816.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7395"/>
    <dbReference type="EnsemblBacteria" id="KJY33407">
        <property type="protein sequence ID" value="KJY33407"/>
        <property type="gene ID" value="VR44_14055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7114"/>
    <dbReference type="eggNOG" id="COG4339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="10020" checksum="607812D8FA3C5EF1" modified="2015-06-24" version="1">MTVYIDPPVWPGHGRMWSHMVSDVSYEELHAFAAGIGCPPRAFERDHYDVPSHRYADAVGAGAVEIGSKELVRRLTQAGLRRPKGRPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGD7</accession>
    <name>A0A0F4JGD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948006.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000387.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32874">
        <property type="protein sequence ID" value="KJY32874"/>
        <property type="gene ID" value="VR44_15145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7447"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045513">
        <property type="entry name" value="DUF6479"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20087">
        <property type="entry name" value="DUF6479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470516" evidence="3">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10528" checksum="4E6B099EAD8F0E9C" modified="2015-06-24" version="1">MMNLAAALAMSATGTAFASALGVVVAVLLVGAVWWGVKRRAAEPKPPTAGQQPRRPAAARRPEERREAEGQPFPSDGSRRTAHELKGYGNFGSPEDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGT8</accession>
    <name>A0A0F4JGT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000377">
        <property type="protein sequence ID" value="KJY33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33014">
        <property type="protein sequence ID" value="KJY33014"/>
        <property type="gene ID" value="VR44_14735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7275"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="23805" checksum="86841EB9565EE3A1" modified="2015-06-24" version="1">MDMEKHPADAAADPAPAAPAPAAPAPAAPAPGGLRASDADRDRIAQILSDALAEGRLTAEEHSERLDTLYAVKTVGELQALVRDLPAGAAPAQPSAAPAGAPAGAGPVESVVAVCSSSARKGRWRPGAHTRAVSVLGDITIDLTEAVFEQQVTEFNVVAVLGNVEVLVPENVTLRGYGSGLLGNFEVHGGGAAADPQAPVVIVRGLAVLGNIEARPRLGARLVDLADKLRKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH88</accession>
    <name>A0A0F4JH88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33118">
        <property type="protein sequence ID" value="KJY33118"/>
        <property type="gene ID" value="VR44_14430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7147"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8550" checksum="445F028CF939B604" modified="2015-06-24" version="1" fragment="single">PEPFGLRHVWAGSMWRHRFMADDALRTVAPVLRAVHAAAFQVLDENGVDTSAFTNRSSIMNGLIQEPAPRKADVYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI44</accession>
    <name>A0A0F4JI44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000401">
        <property type="protein sequence ID" value="KJY32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32636">
        <property type="protein sequence ID" value="KJY32636"/>
        <property type="gene ID" value="VR44_15585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7517"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8680" checksum="20EA13F7A4A7AF4B" modified="2015-06-24" version="1" fragment="single">MDYLDLGPVRVSTTPRTPAPDPDRYQLALVTGDLVLCDTAHPYEAATPATRTVVLQLPRTALPFRPERVDRLLAQRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIB9</accession>
    <name>A0A0F4JIB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33508">
        <property type="protein sequence ID" value="KJY33508"/>
        <property type="gene ID" value="VR44_13850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7049"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="77"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="35711" checksum="A3793663D5F562AF" modified="2015-06-24" version="1">MALDESAAIGAVVRALEEGMGAEDLLLDVIASVQRRVGREWAADRITVAQEHAATAINDRAVTALTLHPSAQTAPTRGRVAVACVEGEWHALPARLLAEVLRLRGWRVDYLGAQVSAPHLVAHLHRTGPDLVALSGSLATRLPAAHAAITACQAVGTPVLVGGAAFGPGSRYARLLGADGWAPDARAAADALARGPLPRVRPGHHAIDDLPHLRDQEYTLVARSRPQLVGSVFGQLADACPAMRTYSEVQREHTAEDLSHIVEFLAAALYTGDEDLFCGFLEWTAGVLDARGVPSASLRPALELLGRELQDFPRATAILRAGAARLTRTPLSPAGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIK2</accession>
    <name>A0A0F4JIK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33598">
        <property type="protein sequence ID" value="KJY33598"/>
        <property type="gene ID" value="VR44_13640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7003"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="19960" checksum="D399A23C70032E80" modified="2015-06-24" version="1" fragment="single">LASDATVWAAGFAVSPIAAAAGLAVTETGRILVDRTMRSLSHPNVYAAGDSVHAIGDNGLPLPMSCATAGFTGMQALQAIMGRLTGSKVGHVKLAYLGNHISLGRRDGILQPVDREGRATPRHFGGRKAARIKEAILRTARWTSWHPTFRLPKRKRHLTAAPQASAAHAPQSSAAHAAPYAPDAPAGRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ00</accession>
    <name>A0A0F4JJ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947663.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33789">
        <property type="protein sequence ID" value="KJY33789"/>
        <property type="gene ID" value="VR44_13225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6863"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="PTHR14202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="SSF140864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="5">
        <location>
            <begin position="26"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="57884" checksum="FB87322B06C63B07" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ94</accession>
    <name>A0A0F4JJ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000332">
        <property type="protein sequence ID" value="KJY33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33853">
        <property type="protein sequence ID" value="KJY33853"/>
        <property type="gene ID" value="VR44_13075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6675"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="31989" checksum="B0CA18675047A6F7" modified="2015-06-24" version="1">MAASAVTAALSLDATVVLLTPVVLATSARLGARPRPHVFATAHLANTASLLLPVSNLTNLLAFAASGLTFTRFAGLMALPWAVAIGVEYVVFRRYFRGDLAAPPEHVPEAAEPAPLPRFATAVLALTLAGFAVASLAGASPAWAALAGAVALGVRALRRRETTPRRLLASTAPAFCLFVLALGVVVRAVVDHGLGDGLEWLTPDGDSLPALLAVAGVAAVLANLINNLPAVLALLPLAAPAGPGVVLAVLIGVNIGPNLTYAGSLATLLWRRMLHVHGEDVRLGDFTRLGLLTTPAALAAAVAALWAGLRLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKR3</accession>
    <name>A0A0F4JKR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000293">
        <property type="protein sequence ID" value="KJY34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947444.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000293.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34373">
        <property type="protein sequence ID" value="KJY34373"/>
        <property type="gene ID" value="VR44_12060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6497"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="17104" checksum="D1114613AABDAE08" modified="2015-06-24" version="1">MDVTLRPVRDEDLEVFYAQTNEPEAVRMAAFTHEDPADRARFDAHWARIRHDPGVLALTVVGADGEVVGHVGVFGPPGEREVTYWIGRAHWGRGAATAALRALLGAVPDRPLHARAAADNGASLRVLDKCGFLVTGHERGFAHARGEEIDEVVLTLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLS9</accession>
    <name>A0A0F4JLS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947303.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34774">
        <property type="protein sequence ID" value="KJY34774"/>
        <property type="gene ID" value="VR44_11300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6154"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="13072" checksum="0D74FECE90D16E93" modified="2015-06-24" version="1">MGARYYGADSESGDRVDDPSEDALFMLISDLNDSDNTFVVIQPDEDDPDWFASVAVLDEGGYEVVQRDATRNEHEVTTATSINDIARDLTIWMAARTFPGRPTSHGLVDTADRWSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMV9</accession>
    <name>A0A0F4JMV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947196.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35159">
        <property type="protein sequence ID" value="KJY35159"/>
        <property type="gene ID" value="VR44_10750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5899"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046238">
        <property type="entry name" value="DUF6271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19787">
        <property type="entry name" value="DUF6271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="48060" checksum="87ED197DFAE6000C" modified="2015-06-24" version="1">MDKICLTLPTNRACADTIEAVGREAAHAAHHFGVEVHLLVLDSADRPAFTRHARAVHTAGLAPGVVAHHLDEAGQRAFLRAAIDRAGLAGPERMLALMLPPAVSYGACTNRAFLIAAALGCRSVHRRDSDSRYQEQNGEPVFPIGQELAFLGRKAADAAGSVTEVLLAAEHTDRTVAMVGGSFVGVPSVDLTDLQQRAPDVHREVIGLWAPAAWSEQERERLVDESFKGAGTEPFTHDRTVLGPVDPMRVDMCNIAFHHEVHERIPLPPATDTIGSDYFLFHLLYHAGLPGVLHNRHIVNFHTDERKTGAGFTAYQTRYAKFLLSMLPFRFLHERMAQEGGALLDGLHRLRAEAVSGLVRESTALDDEENVHRLDTLTRSYRTLGGAYARTAESLHRQGPRLLAEARADMEDFAHLIDAWEPLVHAARTTPLHGKGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN47</accession>
    <name>A0A0F4JN47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946916.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35792">
        <property type="protein sequence ID" value="KJY35792"/>
        <property type="gene ID" value="VR44_09230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5110"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7588" checksum="D814559145A0B63F" modified="2015-06-24" version="1">MAWTWRFEAADGSETSPAVEPEEFTTQGDAESWIGEVWKELLDGGAESVTLFEDGSEIYRMSLKAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNM1</accession>
    <name>A0A0F4JNM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000198">
        <property type="protein sequence ID" value="KJY35805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946901.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000198.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35805">
        <property type="protein sequence ID" value="KJY35805"/>
        <property type="gene ID" value="VR44_09135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5091"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471207" evidence="4">
        <location>
            <begin position="32"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="58"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="246"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="416" mass="45067" checksum="330383BE86A3C09B" modified="2015-06-24" version="1">MKHSPRLWTVLSCSLLVASLGAGATACGGSADNPLSARPYDAAGQVTFNQPPGGGRAADPDKPLEVTAKGTDSRITDVTAVDTHGRRLAGELSAKGDRWHSTTPMAAGVHYTVTVSTEDRHGAPGQRTLAFDTTPAKKLLKVEFGPDEGKYGVGQPITAELSEPVKDKAARALVERGLVIDTPQPVEGAWHWVDDKNLHFRPKDYWPAHSWVSVRSNLEGVKIEDDLHGSASKPLKLEIGDRVEVTTDAAAHTLTFERNGEVINTIPVTTGKPGFSTRNGVKVVLGKQYFVQMRGDTVGIGGSEYYNLPVYYATRVTWSGEYVHAAPWSVGSQGYENVSHGCTGMSTGNAAWFYENITEGDIVRVINSIGEDMEPFGNGYGDWNLDWKEWRDGSYLLKGTQEGRSAVDQARLRPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPA3</accession>
    <name>A0A0F4JPA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946847.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36005">
        <property type="protein sequence ID" value="KJY36005"/>
        <property type="gene ID" value="VR44_08840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5014"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="20078" checksum="1528ACEC7DA1E23B" modified="2015-06-24" version="1">MGRRFTPDAPGSQDADAAHSGSCAHDLHWAGEMRSALGVASLLCTALFAVDAASGRLGPARGALWAGLAFLLFAIMLPQRVSVRPGRLSARRMLTTDTVRTDSLVSVHWTDGVAQRLVLRDAQGNRAEIDPTVLTRNPAMWHLLDTDGRAAIQRGTLREGATALRELARHIDRETAHTVFKVSGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ69</accession>
    <name>A0A0F4JQ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methlyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000155">
        <property type="protein sequence ID" value="KJY36507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36507">
        <property type="protein sequence ID" value="KJY36507"/>
        <property type="gene ID" value="VR44_07900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9632" checksum="63723441A7FA73F4" modified="2015-06-24" version="1" fragment="single">MSEDHTRVQEFFGARADAWDEKFPEDGPAFTAAVAECGIGPGERVLDAGCGTGRALTPLREAVGPSGTVLGVDLTERMLAAARRAGRGADGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQA3</accession>
    <name>A0A0F4JQA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="1">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="1">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnB</name>
        <name evidence="3" type="ORF">VR44_08905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946859.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35918">
        <property type="protein sequence ID" value="KJY35918"/>
        <property type="gene ID" value="VR44_08905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4951"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01677">
        <property type="entry name" value="Salvage_MtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="PTHR10640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20884" checksum="66E3B48E7A330417" modified="2015-06-24" version="1">MTAVTGLEQAGAVLAAEAARFASFGWMRGTSGNLSVLLSREPFRLAVTAGGHDKGELTAEDVVLVDGRGAAVGGGRPSAEAELHARVARLTGAKAVVHVHTVASVLMGRRQPGGIVLKDLEMLKGIGHPAEGEEVTLPVIANSQDMRVLGDRLEAARDPRMPAVVVAGHGLYVWGDSPRQARHHTEVVEWLLELELAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQB3</accession>
    <name>A0A0F4JQB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000163">
        <property type="protein sequence ID" value="KJY36400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946712.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000163.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36400">
        <property type="protein sequence ID" value="KJY36400"/>
        <property type="gene ID" value="VR44_08115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4450"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470790" evidence="2">
        <location>
            <begin position="44"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="40355" checksum="7C3CAB6918B02D09" modified="2015-06-24" version="1">MNDHVVNRPEGAAMGRRRFLTAAAATGIVATAGLAASEGPARAASAHRPAAAGTFRVPAEDVRHTRTWMAFPDSSSIWGRTLSGVQSDIALIARTIAKYEPVYLCANSASAAKARSLAGPSVTVITSIPVDDCWMRDSGPVFRTDGAGGLDAIGLNFNGWGNKQAHARDALVAGRIAAHAGVPFTAAGVVGEGGAVEQDGAGTPLMATRSSLVNGNRNPGASQAQIEAALRAAYGASEVIWFDGVVGQDITDDHVDATSRFLAPGRALVQMPLATDTDVYAKDARKQYQVLSAATTAGGTRMAVEKLQGPDYDRIRSTNRDFLASYANYYLCNGAVITGQFGDAGADTAARATLARLYPGRTVEQLDIDRLGTGGGGIHCVTQQQPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR69</accession>
    <name>A0A0F4JR69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36253">
        <property type="protein sequence ID" value="KJY36253"/>
        <property type="gene ID" value="VR44_08265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4552"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="32296" checksum="DBD807E1ADCF7BFE" modified="2015-06-24" version="1">MELLQATRRVLIDNDNLFGPHRVIPTVQQQIAAIKELRVDRRGTDRRQLLQLQTQYSELCGWLYQDLGDFRAAQHWMREALEASHMAGDDELTTYILARRSQLAGDMNDPIEAVDVAEAAEDRAVPRSRLAAVAATYGAHGHALRNDPLSAQRAYEHALELHAIMDPDPSSPWGVWLDAAYIDVQRAHSLAALGDHRAAAEGFRNAISRLPAGYHRDRGVYLGREAVSLARAGEAERAAVVGLQALSIAKETGSDRISRELAQLDGILDQWRTVPGVSDFRDALTDAVLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR77</accession>
    <name>A0A0F4JR77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase I</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">polA</name>
        <name evidence="4" type="ORF">VR44_07035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000131">
        <property type="protein sequence ID" value="KJY36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946512.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000131.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5299"/>
    <dbReference type="EnsemblBacteria" id="KJY36872">
        <property type="protein sequence ID" value="KJY36872"/>
        <property type="gene ID" value="VR44_07035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3622"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLAc" evidence="3">
        <location>
            <begin position="284"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="528" mass="57587" checksum="713EA45B13C99A32" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS86</accession>
    <name>A0A0F4JS86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000197">
        <property type="protein sequence ID" value="KJY35816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35816">
        <property type="protein sequence ID" value="KJY35816"/>
        <property type="gene ID" value="VR44_09125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5089"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="27" mass="2807" checksum="DB8D873E3324EF99" modified="2015-06-24" version="1" fragment="single">MRATARVLVYSDDAGTREQVRLGAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSJ1</accession>
    <name>A0A0F4JSJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">VR44_07135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946527.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4616"/>
    <dbReference type="EnsemblBacteria" id="KJY36799">
        <property type="protein sequence ID" value="KJY36799"/>
        <property type="gene ID" value="VR44_07135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3771"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="505" mass="54026" checksum="B6E2B3B67B87C0C0" modified="2015-06-24" version="1">MPRGDGRLNHDLLPGEKGPQDACGVFGVWAPGEEVAKLTYFGLYALQHRGQESAGIAVSNGSQILVFKDMGLVSQVFDETSLGSLQGHIAVGHARYSTTGASVWENAQPTFRATAHGSIALGHNGNLVNTAELAEMVADLPRQDGRATQVAATNDTDLVTALLAGQTDDEGNPLTVEESAAKVLPQVKGAFSLVFMDEGTLYTARDPQGIRPLVLGRLERGWVVASETAALDIVGASFVREVEPGELIAIDENGLRTSRFAEAKPKGCVFEYVYLARPDTDIAGRNVYLSRVEMGRRLAKEAPVEADLVIATPESGTPAAVGYAEASGIPYGSGLVKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIRGKRLVVVDDSIVRGNTQRALVKMLREAGAAEVHIRISSPPVKWPCFFGIDFATRAELIANGMTVDEIATSLGADSLSYISLDSMIEATTIQKPNLCRACFDGEYPMELPDPQLLGKQLLESELAGGSDAADALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU34</accession>
    <name>A0A0F4JU34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_06040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946324.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37268">
        <property type="protein sequence ID" value="KJY37268"/>
        <property type="gene ID" value="VR44_06040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2544"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="56815" checksum="0DAB1C7EC4681EC5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU57</accession>
    <name>A0A0F4JU57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946275.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2542"/>
    <dbReference type="EnsemblBacteria" id="KJY37369">
        <property type="protein sequence ID" value="KJY37369"/>
        <property type="gene ID" value="VR44_05780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1971"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12599" checksum="216443A3F3A3B1DF" modified="2015-06-24" version="1">MAGEPQADCLFCKIVEGKIPATVVRETETTIAFRDINPQAPTHVLVIPKVHYPDAASLAAAEPAVIADILREAGEIAAEEKIADHGYRVVFNTGAGAGQTVFHAHLHVLGGRGLQWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU63</accession>
    <name>A0A0F4JU63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946280.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2548"/>
    <dbReference type="EnsemblBacteria" id="KJY37374">
        <property type="protein sequence ID" value="KJY37374"/>
        <property type="gene ID" value="VR44_05810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1977"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28811" checksum="24B01B1BC5449A69" modified="2015-06-24" version="1">MREYSPDLTPQWKRPKAVPEVPADPDLVVEVAGTDFCGAVVACEAGTVTLEDRFGKRRVFPLEPRGFLLDGAVVTLTRPSRAPAAPARTASGSIAVPGARARVARAGRIYVEGRHDAELVERVWGDDLRIEGVVVEYLEGVDDLAAVVAEFAPGPDARLGVLVDHLVPGSKESRIAASVSGPDVLVVGHPYVDVWQAVKPSALGIGAWPEVPRGQDWKTGVCRALGWPENTGAAWQHILSRVTSYRDLEPTLLGRVEELIDFVTGSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUG9</accession>
    <name>A0A0F4JUG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37992">
        <property type="protein sequence ID" value="KJY37992"/>
        <property type="gene ID" value="VR44_04535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.716"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24968" checksum="BB70C746B5F7F135" modified="2015-06-24" version="1">MRGTGVVRGGFGLIGPRRERHVVPAADLDALAVPVGDDGVVIGVDAEGRPAVLGVNRPTPYEVTLIGGLWTAQVMALRTAATGARVAVETGRPQVWNELARAAGGGQQCVTLHEVGRVPPQGASAGSPVLVVRDCGMRPPRGRVVAGPWQSVLTLLPYLSPTAPRLLRNSALVGVQRVSPDEAEQVGALMRLPRGAVDSLPTLGDGVTLWCTQRDRKFVMTQATETETGLLGAARRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK0</accession>
    <name>A0A0F4JVK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000093">
        <property type="protein sequence ID" value="KJY37778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946135.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000093.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37778">
        <property type="protein sequence ID" value="KJY37778"/>
        <property type="gene ID" value="VR44_05005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1316"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="28610" checksum="ABB5C7113D3F2571" modified="2015-06-24" version="1">MGYSVGQVAGFAGVTVRTLHHYDEIGLLCPSGRSGAGHRRYDDADLDRLQRILFYRELGFPLDEVAVLLDDPRSDPREHLRRQHALLTDRIARLQQMAKAVEHAMEAKKMGITLTPEERFEVFGDKDPEQYAEEVERRWGGTEAYAESQRRAASYTKEDWQRIQDEVADWGARYAALVAAGEPADGEAAMDMAEEHRQHICDRYYDCGYEMHVCLGGMYVSDERFKAFYDGMGEGVAEHLRDSITANAVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW59</accession>
    <name>A0A0F4JW59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945805.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38602">
        <property type="protein sequence ID" value="KJY38602"/>
        <property type="gene ID" value="VR44_03160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7847"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24869" checksum="85E7D0A8A765BB03" modified="2015-06-24" version="1">MSGSGGGVTRNTLRQQIADALRDEVLAGRLRPGSEFTVKQIAEQYEVSATPVREALVDLAAQGLLESVQHRGFRVRAYTVDDYRGMIEARMLILDGIFRRLVECGTAPGSAERLVSVRRRAEEARRAARSGSLEVLIGYDLRFWRELSGLAGNTYITEFLHRIRVQCWVFSVPYLQEAPEPATALWDKHGELVDAVTLADAEEVRRIVRAYNQHGLDWAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWA0</accession>
    <name>A0A0F4JWA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38647">
        <property type="protein sequence ID" value="KJY38647"/>
        <property type="gene ID" value="VR44_03145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7844"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="31242" checksum="722C635E34D428FE" modified="2015-06-24" version="1" fragment="single">LLRIVEAEPDLDGVPAELRDLVADCLRKDPAARPDPAAVLARIGAGDTVADGRALEPWLPAPLVAQLGRHAVQLLDREDTGPAHAPGAVAPVAPVAAVSPPAPAVVPATRVAPVHHYGPPPGYLMPPPAAPAPRPRAASAVFLVATALVVATAAGGAVYALMNSGGGTPQTPGGTRSPASSPANGSTAGTNDPGTGSSGSGTPAGRPGVLPAGYAGSWRATSGSSSWHLVLTPGAVGDSVMTLSVDAPGYSCSWRATLRNAPDPVELNGSTVVSGAQPTCTPGGWSRLRLLPDGSLRRELDGSASAPLTYDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYT9</accession>
    <name>A0A0F4JYT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042817427.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000050_gene3507"/>
    <dbReference type="EnsemblBacteria" id="KJY39310">
        <property type="protein sequence ID" value="KJY39310"/>
        <property type="gene ID" value="VR44_01765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5756"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7130" checksum="A18536D05825B432" modified="2015-06-24" version="1">MAAGTVKWFNAEKGFGFIEQDGGGPDVFAHYSNIAAQGFRELQEGQKVSFDIAQGQKGPTAENIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZR3</accession>
    <name>A0A0F4JZR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan bridge formation protein FemAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945395.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4752"/>
    <dbReference type="EnsemblBacteria" id="KJY39615">
        <property type="protein sequence ID" value="KJY39615"/>
        <property type="gene ID" value="VR44_00965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2906"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="42778" checksum="B6633C5B37D08268" modified="2015-06-24" version="1">MSLSLRTISREQHLAYLQSLPSASHCQVPAWADVKNEWRSENLGWFDKSGELVGAALVLYRQLPKVKRYLAYLPEGPVINWYAPNLEEWLQPMLAHLKQQGAFTVKMGPPVVIRRWNSAAIKAGIQDPEVKRLRDVEASYIEPRAFEVSDKLRRMGWQQGEDGGAGFGDVQPRYVFQVPLANRSLDDVLKGFNQLWRRNIKKAEKAGVEVVQGGYEDLPTWQYLYEITAERDKFRPRPLSYFQRQWTALNSEDPNRMRLYIAKHEGEPLAAATMLTVGQHVWYSYGASANHKREVRPSNAMQWRMLRDSYALGASVYDLRGISDTLDENDHLFGLIQFKVGTGGEAVEYVGEWDFPLNKMLHKALDIYMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZX8</accession>
    <name>A0A0F4JZX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945835.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38576">
        <property type="protein sequence ID" value="KJY38576"/>
        <property type="gene ID" value="VR44_03330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7883"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="15448" checksum="E6C43F15048516F3" modified="2015-06-24" version="1">MSATDQGAPGAERTLGQLVAAATAEMSALVHDEIALAKVEIKQDVKRAGIGSGAAIAAGVLLLFSLPVLSFAAAYGIHNLGLGLAWSFLIVGVAFWLLAGLVGLLAVAKFKKVKPPVKTIDSVKQTAAVVGTVKPHPRPVSDQAVGVARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K003</accession>
    <name>A0A0F4K003_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">VR44_00355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945288.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1039"/>
    <dbReference type="EnsemblBacteria" id="KJY39947">
        <property type="protein sequence ID" value="KJY39947"/>
        <property type="gene ID" value="VR44_00355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.69"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13442" checksum="607801B06F26A97F" modified="2015-06-24" version="1">MAYGVKIAKGDAYKRAAKARRHIRIRKNVSGTAERPRLVVTRSNRNIVAQVIDDLKGHTLASASTLDTSIRGGEGDKSAQAKQVGALVAERAKAAGVEAVVFDRGGNRYAGRIAALADAAREAGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0A0</accession>
    <name>A0A0F4K0A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000018">
        <property type="protein sequence ID" value="KJY39529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945474.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4165"/>
    <dbReference type="EnsemblBacteria" id="KJY39529">
        <property type="protein sequence ID" value="KJY39529"/>
        <property type="gene ID" value="VR44_01385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4708"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14457" checksum="BEE82BA3FBAF061E" modified="2015-06-24" version="1">MSRYDVTDEQWEGLAQVVPLRSRNEWPSRVDHRTIPKAAGASAAEQQRRFVVIRVQIFADAREVAEYLIAQIPVLLDLTGADSEVAKRILDFSSGVVFGLGSGMHRVDRNVFLLAPVGTEVEGIAAAAVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1X5</accession>
    <name>A0A0F4K1X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="9" type="ORF">VR44_00195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945276.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39918">
        <property type="protein sequence ID" value="KJY39918"/>
        <property type="gene ID" value="VR44_00195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.36"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18692" checksum="3AF9C23AA2529B3B" modified="2015-06-24" version="1">MARPDKAADVAELEDKFRSSSAVVLTEYRGLTVKQLKTLRRSLGENAQYAVVKNTLTKIAANNAGITSLDDQFTGPTGAAFITGDPVESAKGLRDFAKENPNLIIKGGVLDGKALSADDIKKLADLESREVLLSKLAGAFKGKQSQAASLFQALPSKFVRTAEALRVKLAEQGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2S8</accession>
    <name>A0A0F4K2S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000020">
        <property type="protein sequence ID" value="KJY39476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945510.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39476">
        <property type="protein sequence ID" value="KJY39476"/>
        <property type="gene ID" value="VR44_01605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5679"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="83"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="651" mass="69121" checksum="C80CB0F80FB6E9B3" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K4F1</accession>
    <name>A0A0F4K4F1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ORF">VR44_00040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945252.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40056">
        <property type="protein sequence ID" value="KJY40056"/>
        <property type="gene ID" value="VR44_00040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="143"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY40056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="513" mass="53139" checksum="D4D935A21C2338EA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1Z6</accession>
    <name>A0A0F4I1Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001816">
        <property type="protein sequence ID" value="KJY15932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15932">
        <property type="protein sequence ID" value="KJY15932"/>
        <property type="gene ID" value="VR44_40675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10867" checksum="E066AD723D3D285B" modified="2015-06-24" version="1" fragment="single">AWYATPTLAYARELGHDVRPTEAWIRPEHGAYLDAWYSRLRDAYLATMADMGVTTTLTEPEFLTAMETHKHHSPLPTAVLSAIKSTVKGGIGKLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I234</accession>
    <name>A0A0F4I234_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001808">
        <property type="protein sequence ID" value="KJY15967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15967">
        <property type="protein sequence ID" value="KJY15967"/>
        <property type="gene ID" value="VR44_40670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7002"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10793" checksum="A635255476FBD9A0" modified="2015-06-24" version="1" fragment="single">GTSYVREGGFLHDAGEFDPGFFGISPREALSMDPQQRLLLETSWEAFERAGIDPATLSGTRTGVFAGTNGQDYAIGLSPEQTEGMEGHLLTANSASVVSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3Q4</accession>
    <name>A0A0F4I3Q4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_40355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001731">
        <property type="protein sequence ID" value="KJY16615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16615">
        <property type="protein sequence ID" value="KJY16615"/>
        <property type="gene ID" value="VR44_40355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY16615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24129" checksum="8BF2FCED5ED7F1C5" modified="2015-06-24" version="1" fragment="single">LDLRTLRRQSRIPALLRGLVPAPRHRTAAAVSGAAAQGGSAWADRLAGLPVAEQRSIMSDLVGAQAALVLGHSDAAAVSPERAFRELGFDSLTAVEFRNALIAQTGIRLPATLVFDHPTPAALAEFLRTELVGEDPTGAGAEPTPPAGTADDEPIAIIGMSCRYPGGVETPEDLWRLVADGRDGITAFPGNRGWDLDRLFDPDPDHPGTSYADQGGFLHGAAEFDAGFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHE0</accession>
    <name>A0A0F4IHE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001468">
        <property type="protein sequence ID" value="KJY21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952314.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001468.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21094">
        <property type="protein sequence ID" value="KJY21094"/>
        <property type="gene ID" value="VR44_38390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5327"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="41883" checksum="0878162D55140B10" modified="2015-06-24" version="1">MPRPDDDHTGARIREQRRLARLTQRELSDRIPYSLSLLNQVECGARPASAGLVKAVAEALKLDTSRLTGPASVASLSPDRLAALVTPIREALDAYDLGPHPQLADVRPVSVLIEGADEACRQVRAAHLRAAANVLPALIVELTHTASTAPTTAVWRALASAYRTAHDVALKLGYPDLSRVALDRMGWAAGRASDPCLGAVQLYKRAILVRNSTSLRLIRSGHGLLTGQTHREAIAVAGQLHLGAATVAARAGDRSTLVTHIAAAREFAQQVGGEAGEVHWLSFGQVNVALHDLGAAITMRDYDGALVQARALKMPPSALTSRRARYMVDRALVEMETGHVDASLKYLVSARRAAPEQTRHLPGTRAAVRGLVHLSRRPSDSLGAMARWVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJK7</accession>
    <name>A0A0F4IJK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TP_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_38020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001430">
        <property type="protein sequence ID" value="KJY22210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952245.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001430.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22210">
        <property type="protein sequence ID" value="KJY22210"/>
        <property type="gene ID" value="VR44_38020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5170"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY22210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="45101" checksum="183295A001F586AB" modified="2015-06-24" version="1" fragment="single">GWAGLTAAARGALTGAEVLIGGPRQLDLLPAGECAGLRVAWPSPLRPAVPKLMAEHAGRRIAVLASGDPMFYGIGRALSEELGPGALHVHPHPSSVSYACARLGWPVEDTEVVTVVGRPVARVAAALHEGRRLLVLSAGAATPDEIAALLRERGFGPSRMRVLEQLGSEREDAYEGTADGWNREPGDPLNVVAVECRRDPGAPAPRLGATPGLPDAAYEHDGQLTKRHVRAATLVRAATLCALAPAPGELLWDIGGGSGSIGIEWMRTHPSCRAVAVERVPERAGRITRNAAALGVPGLRVVVGAAPAALGGLPTPDAVFIGGGLTAPGLLDAAWAALAPGGRLVVNTVTLESEAVLAGQHRRLGGELVKLAVSHAVPVGGFTGWRQAMPVTQWSVTKPARTEAQAARTADQAAPTAARAARTPDAAAPVTKPKTQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP51</accession>
    <name>A0A0F4IP51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001354">
        <property type="protein sequence ID" value="KJY23815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23815">
        <property type="protein sequence ID" value="KJY23815"/>
        <property type="gene ID" value="VR44_37180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470275" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6210" checksum="5E464325F5C53179" modified="2015-06-24" version="1" fragment="single">MYRSRKRLLATAALWAAASALAAGCGGDGSAHPSGSAPGGGCPAALARAKEAVGRAERTGAGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPJ5</accession>
    <name>A0A0F4IPJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001326">
        <property type="protein sequence ID" value="KJY23940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001326.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23940">
        <property type="protein sequence ID" value="KJY23940"/>
        <property type="gene ID" value="VR44_36800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4672"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8365" checksum="05188E51B8640030" modified="2015-06-24" version="1">METYLTYMLIRFALLAAGAVAVALLVFAVALVLKRRGRLDQVRRQVDPLARSALRAAVRRLEDGAAGTRRKGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQN5</accession>
    <name>A0A0F4IQN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">VR44_37210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001357">
        <property type="protein sequence ID" value="KJY23808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952094.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001357.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3094"/>
    <dbReference type="EnsemblBacteria" id="KJY23808">
        <property type="protein sequence ID" value="KJY23808"/>
        <property type="gene ID" value="VR44_37210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4833"/>
    <dbReference type="eggNOG" id="COG1637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24637" checksum="43BE056354A4526F" modified="2015-06-24" version="1">MRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGSGDEANVWTVVNKAGEKLIITMEEVLHDSSHELGTDPGLIKDGVEAHLQELLADRIETLGEGYTLIRREYMTAIGPVDILCRDASGATVAVEIKRRGEIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLANDRGMDCVVLDYDALRGIEDDKLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISA2</accession>
    <name>A0A0F4ISA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001151">
        <property type="protein sequence ID" value="KJY24900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951502.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24900">
        <property type="protein sequence ID" value="KJY24900"/>
        <property type="gene ID" value="VR44_34030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3732"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15981" checksum="D36795E307C316F2" modified="2015-06-24" version="1">MSVMGQLTCSEGCLARALRAVSAALRHYTDTPVARPYYVRGCVPEPQDAAVIVALWTGPSAREKSNLFLLVPLVSGGLAVPPWGVVAGLMRLGRGTHLFGSVGRRFDGKPVLDGSALVEGGGRSCPCDGSPEPEGPLGFYFERPGEPRHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISB1</accession>
    <name>A0A0F4ISB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001153">
        <property type="protein sequence ID" value="KJY24887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951511.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001153.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene281"/>
    <dbReference type="EnsemblBacteria" id="KJY24887">
        <property type="protein sequence ID" value="KJY24887"/>
        <property type="gene ID" value="VR44_34075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3742"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="57219" checksum="8349CF734B082D55" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISG2</accession>
    <name>A0A0F4ISG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001197">
        <property type="protein sequence ID" value="KJY24594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24594">
        <property type="protein sequence ID" value="KJY24594"/>
        <property type="gene ID" value="VR44_34905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4057"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470097" evidence="3">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="12477" checksum="C3483BDABFB2018A" modified="2015-06-24" version="1">MIARVIPVALLAGLLLAPLPANAAEAPTAHRAAPARSAVAAGAQAGALAGTVRGTSVNASALTQAAGVSKDSKKDSKKSKSKKKKKGFLGKLGTAALIVGVLVVLLIVAAIIAVVVLAARRRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL7</accession>
    <name>A0A0F4ISL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001189">
        <property type="protein sequence ID" value="KJY24649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951622.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24649">
        <property type="protein sequence ID" value="KJY24649"/>
        <property type="gene ID" value="VR44_34700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4005"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26927" checksum="CB2942D38CEDB2FF" modified="2015-06-24" version="1">MSSQHTNQTSEVPAVGADSPFRKEHVLRDEAPQFVLPLVVRIEKAEPPARTDALETAARAVLVLLTDERAHGEGEWARAVRDWQDARIRKVVRRARGAEWRKAAALPGVTVHGGAAEVRVFPPVPLDGWPKELAKLQVSGTDLDDPEPAPTPEPGVPVLWLNPDLGMSAGKAMAQAGHGAQLAWWELTAAERALWQASGFRLAVRTAPRERWAELSGSGLPVVRDAGFTEIAPGSCTVVSDHPALRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IST6</accession>
    <name>A0A0F4IST6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="3" type="ORF">VR44_34500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001177">
        <property type="protein sequence ID" value="KJY24719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951587.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6924"/>
    <dbReference type="EnsemblBacteria" id="KJY24719">
        <property type="protein sequence ID" value="KJY24719"/>
        <property type="gene ID" value="VR44_34500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3883"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="10789" checksum="CCF4E6572A2B9B58" modified="2015-06-24" version="1">MIPGEIAFGDGPVRLNEGRPVTRLTVLNAADRPVQVGSHYHFAEANPGLDFDRRAARGLRLNIAAGTAVRFEPGIPVAVELVPIGGLRTVPGLRGETGGPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT04</accession>
    <name>A0A0F4IT04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001197">
        <property type="protein sequence ID" value="KJY24593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24593">
        <property type="protein sequence ID" value="KJY24593"/>
        <property type="gene ID" value="VR44_34900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4056"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="11534" checksum="A037BBE2A4C09E4F" modified="2015-06-24" version="1" fragment="single">GHLPPLLVRHGEASFLPQPQGSLLGATAGVTYGQEDIGLLPGDHLLFYTDGLVEDPGVDIEEGLESLAATAARLVREGRADTLARTLAAGRKPHRDDICVLDVHLPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU06</accession>
    <name>A0A0F4IU06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951375.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25134">
        <property type="protein sequence ID" value="KJY25134"/>
        <property type="gene ID" value="VR44_33335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3543"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="27223" checksum="A8D38106EB4D0A26" modified="2015-06-24" version="1">MNREQISKLAHTHHPIKSPLNDDSVSSLLSQALPRGDERVLDLGCGSAEWLLRALTTHPDVHAEGVDISESDLEEARQKAVRLGIDARLTLHHQKAEDFTSPHPFDLILCVGSTHALGGLLPTLEAARTHLAPGGRVLIGDGFWERTPTPEAIEVLGDFADLPTLVDQVVTNGWTPVQGHTSTRQELDDYEWSNWGTLADWALDHPTHPDSPQILTWATTRRTEWLHTYRDSWGFTTLILRPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUE0</accession>
    <name>A0A0F4IUE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001122">
        <property type="protein sequence ID" value="KJY25093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951399.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25093">
        <property type="protein sequence ID" value="KJY25093"/>
        <property type="gene ID" value="VR44_33440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3567"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="14"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="112"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="36199" checksum="C5A3E525AA9FB13F" modified="2015-06-24" version="1">MEILAFGVTADEEPLLERAFAREGRHEVRCLDVFLDEDTAPIAAGYEVVSSSVNADLGGRVLNVLAAGGTRLVAQRSTGFNNIDLDAARRLGLTVSRVSYYSPYSVAEFAWTLAMAVNRRIVRASNRTRDFDFRLNGLMGRDMRGRTAGVLGTGKIGEAFTRIAHGFGMRLLGWDIAPNPACVELGMTYVEKEELFASADLISLHVPLMEATRHLVDAGALAVMKDDAILVNSSRGGLVDTEALVGELREGRFAGVGLDVYEAEAGVFFLDKSLEAFPDDTLARLITFPNVLVTSHQAYYTHDAVGQIIEATVRNVADYLAGRRSENTLVPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV93</accession>
    <name>A0A0F4IV93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001077">
        <property type="protein sequence ID" value="KJY25413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951234.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25413">
        <property type="protein sequence ID" value="KJY25413"/>
        <property type="gene ID" value="VR44_32565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3324"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20955" checksum="AB9C31D66602F203" modified="2015-06-24" version="1">MDPETEQVLDAIGPRLRTLRRTRGLTLEALAATTGISVSTLSRLESGRRRPTLELLLPLARAHRVALDDLVGAPPTGDPRVHLEPLRKHGTVIVPLTRYPGRIQVFKQVLTPREPRQVTHEGYEWFYVLAGEVRLILGDEELVLRPGEVAEFDTARPHWFGPADGGVAEVLHLFGPRGDQAVVRAAPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVV1</accession>
    <name>A0A0F4IVV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001164">
        <property type="protein sequence ID" value="KJY24821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24821">
        <property type="protein sequence ID" value="KJY24821"/>
        <property type="gene ID" value="VR44_34225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24699" checksum="55A0DE2E1EE1C755" modified="2015-06-24" version="1" fragment="single">MQTSDVAPDPNNADVDIDVYGWVLEHRTVDVDAVAAGTGHEADEVRRSVSRLRASRLLHVSPVDPTVAFAVAPDTAAEQLVAPLEAQIRDQQRAISGIREDLGRFLPHYLGRRSTGESLEVLESLEDVRGALNRASVNCTTEMISSQPGGGSRVPEAMQEALRRDETMLQRGISIRTLYHHTARFNGPSQAYVAAASVLGAQYRTAHELFGRLIAFDRELAFIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW34</accession>
    <name>A0A0F4IW34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001018">
        <property type="protein sequence ID" value="KJY25849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951021.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25849">
        <property type="protein sequence ID" value="KJY25849"/>
        <property type="gene ID" value="VR44_31435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2778"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="2">
        <location>
            <begin position="151"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="28336" checksum="905423419CC888F5" modified="2015-06-24" version="1">MTLEFPVLLRLIDERSAAFRAAVASAPGLDVQVPTCPEWTLFDLAQHIGEGRRDWAATVAAGPAPAKSAAEAAPAAPREREALLAWLAESTDQLLDALRKAGPDRGCWAWWETLQSPHTAAAVARHQLQQMAVHTYDAQITVGAPQPLPDEVALDGVEEFLSTCVATTSAWPHQPAAIDFHASEGRSWRLSLSADGARSTRLPGPGGTPATAAGQAPDPAVAFFSMEGTAGELVLSLYDRIPVDSLKTEGDRRVFEQLSAWDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWW6</accession>
    <name>A0A0F4IWW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_30790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000978">
        <property type="protein sequence ID" value="KJY26134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950905.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000978.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26134">
        <property type="protein sequence ID" value="KJY26134"/>
        <property type="gene ID" value="VR44_30790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2615"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35184" checksum="23DF3D8122132A36" modified="2015-06-24" version="1">MTGFVLKRLGSALLVLLALSVLVYALFYVAPGDPARLACGERCNPQQIAQVREQLGLNAPVVTQYLHFLQGLLAGRDYSGGAGLVLHCDAPCLGFSYQNDRQVTELLLERLPATLSLALGSLVIWLVVGVGTGLLSALRRGGPTERVLTVLTLAATGTPVFILGLLLLMAVCAYLQWLPFPTYVPFGEDPEQWAWNLLLPWVTLGVFESAKYARLTRSSTLETLAEDHIRTFRAYGVGERRIVTRHAVRGAVAPVIALSAVDFGTMIGGAVLTESLFGIPGLGKTLIDGVRVVDLPVVVGVVLAIGTAVVLAGAVADLLYALADRRVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX95</accession>
    <name>A0A0F4IX95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">VR44_30460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000960">
        <property type="protein sequence ID" value="KJY26274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950845.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000960.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5349"/>
    <dbReference type="EnsemblBacteria" id="KJY26274">
        <property type="protein sequence ID" value="KJY26274"/>
        <property type="gene ID" value="VR44_30460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2506"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="28288" checksum="4DD7CD4C42C7799E" modified="2015-06-24" version="1">MTSVENGRTPLMAGNWKMNLNHLEAIAHVQKLAFALADKDYDAVDVAVLPPFTDLRSVQTLVDGDKLKIKYGAQDISAHDSGAYTGEISGPMLSKLKCTFVAVGHSERRQYHGETDELCNAKVKAAFRNGITPILCVGEGLDVRKAGNQVAHTLAQVDGGLKDVPADQVESIVIAYEPVWAIGTGEVATPEDAQEVCGAIRGRLAELYSQELADKVRIQYGGSVKAGNIAAIMAQPDVDGALIGGAAGGAALDVDEFVKIVRFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXF8</accession>
    <name>A0A0F4IXF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_29430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000910">
        <property type="protein sequence ID" value="KJY26692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950659.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000910.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5700"/>
    <dbReference type="EnsemblBacteria" id="KJY26692">
        <property type="protein sequence ID" value="KJY26692"/>
        <property type="gene ID" value="VR44_29430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2251"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="21302" checksum="0A9EA7E9B693EDDA" modified="2015-06-24" version="1">MFDFAVFGSLFLTLFVIMDPPGITPIFLALTSGRPAKVQRRMAWQAVCVAFGVIATFGICGQQILDYLHVSVPALMIAGGLLLLLIALDLLTGKTDEPKQTKDVNVALVPLGMPLLAGPGAIVSVILAVQKAEGFGGQLSVWTAIAAMHVVLWLTMRYSLVIIRIIKDGGVVLVTRLAGMMLSAIAVQQIINGVLQVVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXI8</accession>
    <name>A0A0F4IXI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_32585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001081">
        <property type="protein sequence ID" value="KJY25391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951237.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001081.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25391">
        <property type="protein sequence ID" value="KJY25391"/>
        <property type="gene ID" value="VR44_32585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3328"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02549">
        <property type="entry name" value="Peptidase_C39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039563">
        <property type="entry name" value="Peptidase_C39_single_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470363" evidence="2">
        <location>
            <begin position="31"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="3">
        <location>
            <begin position="249"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="463" mass="49196" checksum="972B526F9626F8DB" modified="2015-06-24" version="1">MTAPTPRRALLAIALAAATAATVPGGRASAAPGSGPAQPERAPAPAPAAAGAAVDNRFWYAYAHWQAGTHRGTTAVNGTRPGLQIKTPAGRTEYTDPHTGRKSSWEYATWTSPLHRSTVPATEAIASWNARTPAGSWIQTELRVTYPDGTTGPWYVMGRWAAGDGDIRRTSVDGQTDGRTTVWTDTLAVDGPAAAAGVRITHWQLRMTLYRKPGAPGGPTVWLAGAMASAVPDRFTVPASAPSGRAHELKVPRYSQEVHAGQYPEYDNGGEAWCSPTSSQMIIEYWGRRPSAASLAWVDPGYADPQVCHAARSTYDAAYKGCGNWPFNAAYAATYRDLAGVVTRLGSLTDLETLVAAGIPAITSQSFLREELTGAGYGTAGHLMTVIGFTAAGDVIANDPNSADNASVRRVYKRREWENIWLRTKRRNAEGKTVSGSGGVCYLYAPARPTAAQISALRQVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY70</accession>
    <name>A0A0F4IY70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000881">
        <property type="protein sequence ID" value="KJY26970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000881.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26970">
        <property type="protein sequence ID" value="KJY26970"/>
        <property type="gene ID" value="VR44_28715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2075"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470242" evidence="1">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="11369" checksum="D80B781FDC2FC94C" modified="2015-06-24" version="1">MARHAASDPSPQRLRSAGLTLSLAGAALAMAAGGAQAGELDPAAAVSGVVDPIANLKVNPLAHTGVDPLDNGVGTKVADFPAVGTTMVTGVLTQGPSVKEIPEAAVSSLLGPVLPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYA8</accession>
    <name>A0A0F4IYA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950515.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26982">
        <property type="protein sequence ID" value="KJY26982"/>
        <property type="gene ID" value="VR44_28650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2061"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13047" checksum="7E0D45F720FD295C" modified="2015-06-24" version="1">MAGMVRRSFDDADETRPFEGGKGRLDLLQTDGGAVGRAVFEPGWRWSEHVKPLVGTDSCQAGHTGYMVSGRMHVVMDDGTAEDYGPGDFMQIAPGHDAWVVGDEPAVALDWTGFGDYAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYR3</accession>
    <name>A0A0F4IYR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000864">
        <property type="protein sequence ID" value="KJY27165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27165">
        <property type="protein sequence ID" value="KJY27165"/>
        <property type="gene ID" value="VR44_28305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="450" mass="47146" checksum="CF6BAAAA19D21A2B" modified="2015-06-24" version="1" fragment="single">MPVLPRPGRAGAGPAAADPMDELAGRLDAFVAAAVHPDEIAAVLESDGMTDEYIRLTYGRPDSFTLAEELYHRVPRSFPEPDALPDPWKVSLTACLLRGLIFALPGLAYLLGEPLLEGPPDRLGLPAGTLTLLAGALIGWVWDQTLSHRAYSWLGLGDRAAAGRTLLVGAPVGALLGTAAAFAVPGGPPFSYAFAAGQALYVGAATVLLVLRREQLLLTALAPMAAGSVLALFTDPPVPVRVALLLVSLTAACALALRELPLADGVRAAVRRIRDRTQRHPGEGGAVRWRMLRGAEEDHTRRGPRIGDSVPYGVFGLGTGLLVLYAALGEVLTGGPAEAVAAPSAVALTLSMGPAEWLLHRFRSGSLAGLRAARSPRAFRRRMLTTLAGCLAAYLAVLLLLGTAGTLLWPHAPGLTWVRVTTLLLLGTVMWTGLLLQSFGAVRPAAVVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZM0</accession>
    <name>A0A0F4IZM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iso_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000886">
        <property type="protein sequence ID" value="KJY26918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26918">
        <property type="protein sequence ID" value="KJY26918"/>
        <property type="gene ID" value="VR44_28875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2115"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17191" checksum="1E4DEC2F368A4278" modified="2015-06-24" version="1" fragment="single">AGPLWQSRFRAIAASYPDVECDHLYVDAAAMELIRDPARFDVVVAGNLFGDILSDEASMLAGGLGVAPSASYDPDDTEFAGVFEAVHGSAPDLVGTGRANPLASVMSYSMMLDRLGLRAAHAAVERAVDEVLCGDLLTPDLGGTARTGEVGDLICRAVARHDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZM8</accession>
    <name>A0A0F4IZM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000978">
        <property type="protein sequence ID" value="KJY26136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26136">
        <property type="protein sequence ID" value="KJY26136"/>
        <property type="gene ID" value="VR44_30800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2617"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="553" mass="58181" checksum="38042BBF5BF5BD5E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J067</accession>
    <name>A0A0F4J067_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950470.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000868.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27118">
        <property type="protein sequence ID" value="KJY27118"/>
        <property type="gene ID" value="VR44_28410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2007"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="36737" checksum="46E145CC87B0AB19" modified="2015-06-24" version="1">MPQNRQPSEPRYGNRPTMKDVAARAGVGLKTVSRVVNGEPGVTPDTERRVQDAIEALGFRRNDSARVLRKGRTATVGLVLEDLADPFYGPLNRAVEEVARTHGALLINGSSAEDPDRERELALALCARRVDGLIVIPAGDDHRYLEPEIRAGVATVFVDRPAGGIEADVVLSDSFGGARDGVAHLIAAGHRRIGFIGDHPRIHTATERLRGYREAMALAGLPVAGSWVSLGATAPERVAAAARAMLAGPEPITAVFAGNNRVTVTVVRVLAALPRPVALVGFDDFELADLLRPGVTVIAQDPAALGRVATDRLFQRLSGTALPPTRIVLPTRLIPRGSGELPPHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J069</accession>
    <name>A0A0F4J069_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">VR44_27125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000809">
        <property type="protein sequence ID" value="KJY27665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6913"/>
    <dbReference type="EnsemblBacteria" id="KJY27665">
        <property type="protein sequence ID" value="KJY27665"/>
        <property type="gene ID" value="VR44_27125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1610"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="52"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="291"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="42257" checksum="E0F357EF41A9D199" modified="2015-06-24" version="1">MAVTAGKAAAAVSRAAGRGSGSVIGGKVALRLDPDLLGALAQHLDVVLVSATNGKTTTTRLIAEALRASGPVVSNALGANMPAGITSALAGGSDAKYGVIEVDEKYLAGVARDVTPKVIALLNLSRDQLDRAAETRMLAEKWREGLEGSKAVIVANCDDPLIVWSASSSQTVVWVAAGQEWKDDAWSCPSCGGVMQRPGDDWFCGECGFRRPTPTWVLSGDHVLDPHGSAWPIHLQLPGRANKANAATSAAVAAVFGVPPQVALERMYQVQAVAGRYDVVNFQGRELRLLLAKNPAGWLETFSLIDGPPAPVILSVNARGADGTDTSWLWDVDYPRLAGHPIFVIGDRKLDLAVRLEVAGLDFRVCETLDEAVQLAPPGQIELIANYTAFQDVRRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Q2</accession>
    <name>A0A0F4J0Q2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_29955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000935">
        <property type="protein sequence ID" value="KJY26481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950754.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000935.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M04.017"/>
    <dbReference type="EnsemblBacteria" id="KJY26481">
        <property type="protein sequence ID" value="KJY26481"/>
        <property type="gene ID" value="VR44_29955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2373"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023153797" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="11">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="194"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="344"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="519" mass="54206" checksum="A4BD7464826C365A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2A7</accession>
    <name>A0A0F4J2A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000875">
        <property type="protein sequence ID" value="KJY27051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950485.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000875.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27051">
        <property type="protein sequence ID" value="KJY27051"/>
        <property type="gene ID" value="VR44_28485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2024"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="211"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="34207" checksum="E30A9B00981E8EB6" modified="2015-06-24" version="1">MTLVAMPVYDGAMLFEAAIVLEIFGADRSHLTDPWYEFAVCGPQDARLGGMLRVDTPHGLDVLAHADTVIVPSCDDIEADPPGELLEALRAAYRRGARIASLCTGSFVLAAAGLLDGRQAATHWLHAARLAERYPHVHVNADVLYTHDGQILTAAGKAAALDLSLHLVRLDHGAAVANALARILVVPPYRAGGQAQYIAAPVPARSGDGFTALQDWALDRLHEPLTVQDLAARAGMSTRHLTRLFHQSTGLTPLRWLHVQRIRRAQELLETTDTPVERIAVHAGMGTATTLRRHFSRAVGVPPDTYRRTFRGAGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2R0</accession>
    <name>A0A0F4J2R0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GalKase_gal_bdg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000724">
        <property type="protein sequence ID" value="KJY28500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28500">
        <property type="protein sequence ID" value="KJY28500"/>
        <property type="gene ID" value="VR44_25200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7221" checksum="AED447D844168837" modified="2015-06-24" version="1" fragment="single">MNTVVSGDFERVHGHAPEGLWAAPGRVNLIGEHTDYSDGFALPMALPQTAVLAARRRTDGLLRLHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2Z8</accession>
    <name>A0A0F4J2Z8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000766">
        <property type="protein sequence ID" value="KJY28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950054.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000766.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28068">
        <property type="protein sequence ID" value="KJY28068"/>
        <property type="gene ID" value="VR44_26140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1384"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470343" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="110"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="24621" checksum="43346578309F850B" modified="2015-06-24" version="1">MGPHASSTRLVVTALGAALLLSGCALTGVGPVKTADADTTVSEAVTAVELTGVRSGDVEVVPGAGPGVAVRRVVHYRGGTVPTPGQRVSGGVLKFSDGCEDDCWIDYRLEVPAAARVRVESSSGDVVVKGVAGADLTTSSGDVRAEGITGPVKVRTASGRITATGLEGAEAELRASSGDVEAGFVKAPASVSVTTSSGDVGLKAPQGSYKVSADTASGTRRVSLNDVPDARSGITVRTSSGDITVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J321</accession>
    <name>A0A0F4J321_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000765">
        <property type="protein sequence ID" value="KJY28093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28093">
        <property type="protein sequence ID" value="KJY28093"/>
        <property type="gene ID" value="VR44_26090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1373"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470669" evidence="1">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="12999" checksum="49B465AFF1D8BE99" modified="2015-06-24" version="1">MPLLAFPGALTTAAAAPADASGVAADGNYWVWADTNRGGPACGWSGNDADWRTCGAGNDYNMNDRASSWWNNGYSGALGDVRVYEDINYGGASTCAPNGSAGNIPWEWNDRISSHKWVTNCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3D7</accession>
    <name>A0A0F4J3D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949770.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28770">
        <property type="protein sequence ID" value="KJY28770"/>
        <property type="gene ID" value="VR44_24610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.917"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="32152" checksum="E2CEF2D15B448A13" modified="2015-06-24" version="1">MRAIVVNEWGGPENLVEREIDRPEPGLGEVLVRVHAAGVNPVDWKTRASGALIAWGETPVVGWDVSGTVEAVGPGVTLFAPGDEVYGMPHFPRQAGGYAEYVVAPARQLAAKPASLSHAEAAALPLAALTAWQALVDTADVRPGERVLVHAAAGGVGHLAVQIAKARGAYVIGTASAGKHELLRSLGADEVVDYRTVAFEEVVSDVDVVLDGLGGEIAERSLSVLREGGRLVTLPGPDDVPADTRGFRADWVLVEPDRLGLREIAALADDGVLKPLVETVLPLEQAAKAHEIGEQGRTTGKIVLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J402</accession>
    <name>A0A0F4J402_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000733">
        <property type="protein sequence ID" value="KJY28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28428">
        <property type="protein sequence ID" value="KJY28428"/>
        <property type="gene ID" value="VR44_25385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1173"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7589" checksum="6CFA3F5E59C581F7" modified="2015-06-24" version="1" fragment="single">MAEETSAPAGRDGAGQSRRSFLTYLVAAPTLALVTRAGADALAPQAAHAVVPSLPEVADLVDLGDLFILAGAPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4H9</accession>
    <name>A0A0F4J4H9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949784.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28734">
        <property type="protein sequence ID" value="KJY28734"/>
        <property type="gene ID" value="VR44_24710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.939"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21468" checksum="CCF2DCD5EF6EE9F6" modified="2015-06-24" version="1">MTRTPVYTHPVEGFGTVSFTPVEPAADAALIHSWVTEERARFWGMGEASRELVQEIYEDVDRRTTHHAFMVSLDGEQVALFQTYDCAEDRVSECYEVQPGDVGVHLLIGPTKGPARHGFTGALIEAFIAYLFKDGGAVRVVGEPDARNAKAIALLERSGFELGPEVELPEIDLPEVYLPAKPARLAFLNRQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J582</accession>
    <name>A0A0F4J582_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000638">
        <property type="protein sequence ID" value="KJY29497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29497">
        <property type="protein sequence ID" value="KJY29497"/>
        <property type="gene ID" value="VR44_22775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.487"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11113" checksum="DE477AA0CB27F0AF" modified="2015-06-24" version="1" fragment="single">MRLVAACALTGVAVLYAVLCVKLLVVDMTEVACSAGGCPRGLGWLLLWAFAAAAGAALLWWAVLRGRAYRSAALWVAAVFLSPAALLPAWQGFDWLRGPHLTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J595</accession>
    <name>A0A0F4J595_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose:sterol glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000637">
        <property type="protein sequence ID" value="KJY29512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949433.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000637.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29512">
        <property type="protein sequence ID" value="KJY29512"/>
        <property type="gene ID" value="VR44_22755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.483"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="42081" checksum="343C13C20E64E97C" modified="2015-06-24" version="1">MKILIAAAGSRGDVDPYTGLGAALRAAGHDVALAATAPFAPLVRAAGLEFRALPADTRPRGDVTDRRELMRTAAAFLTELGQGFAGAVDAGTDLLLLSTTTAPLGWHLAEATGTPGLGVYLQPTAPTGDFPPVVTGARSLGRLGNRAAGRFALRMADRISEQGAARLRDRLGLAPLTASAMRRQREREHWPVLHGCSTALVPAPADWRPGLDVVGNWWPYVDPAQRLPADLEDFLDAGPRPVLIGFGSMASGEGERLGELAVRALRRAGLRGVLQSGSAGLTADGGPDVLTVGDVPHALLLPRVAAVVHHAGAGTSAAALRAGVPAVTVPVTADQPFWARRLAALGAAAAPLPFASLTAEGLAEALDRVVKEEPYARAARAAARHMATEDGAARVLEAVERIARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J636</accession>
    <name>A0A0F4J636_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949364.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29655">
        <property type="protein sequence ID" value="KJY29655"/>
        <property type="gene ID" value="VR44_22420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.373"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20596" checksum="9818A74D903C0EFE" modified="2015-06-24" version="1">MAVKILIVTGDAAESLEVLYPYQRLREEGYEVHIAAPSRKKLRFVVHDFEEGFDTYTEKPGYTWPADVAFAEVVPEEYAAVVVPGGRAPEYLRNDPEVRRILAAFAGADKPIAQICHGPLITAAAGSLAGRRVTAYPALEPDMRAAGAEFRDSEAVVDGTLVSARAWPDHSAWMREFLTVLRAKAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J644</accession>
    <name>A0A0F4J644_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000626">
        <property type="protein sequence ID" value="KJY29665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29665">
        <property type="protein sequence ID" value="KJY29665"/>
        <property type="gene ID" value="VR44_22360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="21962" checksum="F841FAA71CA1BF30" modified="2015-06-24" version="1" fragment="single">MALVGSSVTVSRSLADAPLFTAQAVRYAAAALILLGLARAARVPVLRPRGREWLWLAGVAATGLVLFNVAVVRGVAHAEPAVIAVAVASVPVLLGVVGPLLEGRRPSRRVLAAAPVVVAGAVLVEGSGRTDAAGVGWAALALACEAGFTLLAVPVLGRHGAWGVSVHAVWMGAVMLAGPAVFTESPSAVAELGAAQWAAVGYLAVLVTAVAFLLWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J656</accession>
    <name>A0A0F4J656_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">VR44_23420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949549.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5187"/>
    <dbReference type="EnsemblBacteria" id="KJY29248">
        <property type="protein sequence ID" value="KJY29248"/>
        <property type="gene ID" value="VR44_23420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.626"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41160" checksum="B777B88ED9A27B33" modified="2015-06-24" version="1">MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPARRDNVIGAASTKREEPAPAPVRAPEPVRPAFGGLGTVTPREEPPAPVELPVEAAPAPPQVPTARPYQDSPAEELDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J665</accession>
    <name>A0A0F4J665_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_22300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000624">
        <property type="protein sequence ID" value="KJY29685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949344.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene476"/>
    <dbReference type="EnsemblBacteria" id="KJY29685">
        <property type="protein sequence ID" value="KJY29685"/>
        <property type="gene ID" value="VR44_22300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.347"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY29685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="41481" checksum="222C403565ED2929" modified="2015-06-24" version="1">MAGSADFDLYRPAEEHDMLRESVRALCEAKILPFAATVDEEARFPQEALDALVANDLHAVHVPETYGGAGADALATVIVIEEVARVCASSSLIPAVNKLGSLPVILSGSEELKAKYLGPLAKGDAMFSYCLSEPDAGSDAAGMKTRAVRDGDFWVLNGVKRWITNAGVSDYYTVMAVTDPEKRSKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYLDNVRIPADRMIGAEGTGFATAMKTLDHTRITIAAQALGIAQGALDYAKGYVQERKQFGKPIGDFQGVQFMLADMAMKIEAARQLTYAAAAKSERVDSDLTFFGAAAKCFASDVAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7H6</accession>
    <name>A0A0F4J7H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000571">
        <property type="protein sequence ID" value="KJY30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30347">
        <property type="protein sequence ID" value="KJY30347"/>
        <property type="gene ID" value="VR44_20685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8852"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="15103" checksum="4473437F7EFC7225" modified="2015-06-24" version="1">MLAPLLVAVLLGAGTDGSGETVSLDGDRPGERLDVTLTRVVDPAGPEPASGGERLVAVELRLENTGTVPYEDSPAPAAHLLDTTGRRFTGLSAPTDAGPPLPGTVTLAPGRSAAGYVVFRLPREARPAAVQFALDAGLGDDVAHWSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7S4</accession>
    <name>A0A0F4J7S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949295.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29818">
        <property type="protein sequence ID" value="KJY29818"/>
        <property type="gene ID" value="VR44_22025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.284"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="496" mass="52623" checksum="5CD44CCC1C38D6E1" modified="2015-06-24" version="1">MPTPVFEEYEPAGDCACPGCAQRRRALARGRAIALRDGGTPAVRGARRALVLATAAGVVLGGGGPAAALLPDHAAPKPRPAEPLPAEPLPGAGRTAGTAHGADARPVPGPGPSARDTPGSPQGGRAPLHGRPRPPASGPGRPGAPSLARRTDRATIINRAKLWLEAQVPYSMSEYWTDGYRQDCSGYVSMAWNLGTNEWTGSLDTFATKITKDELLPGDMLLFHNPADPNKGSHVVLFGGWVDETHTHYIAYEQTPPVTRRLATPYGYWNNGAKYVPYRFNGVTGGILPGDSVPPAQQPTVTFPGASKFGPGADNKYVAELGRMLIDRGALRFYPKGPSTKWSEADRQATEAFQLAQGWTGADADGIPGPDTWRLLVQRQGNDIVPTGRTTPPPGPQAPQVPPAPSAPGVPRPGPAGVPAYPGLRVFHPGRSHPAIAAMGRQLLKKGFGKYYTAGPGQSWTEADRRNVEAFQRAQGWRGAMADGYPGPETWRRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8C4</accession>
    <name>A0A0F4J8C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone GroES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_21445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949182.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29998">
        <property type="protein sequence ID" value="KJY29998"/>
        <property type="gene ID" value="VR44_21445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.166"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="41738" checksum="2D97DB6E5A5DA080" modified="2015-06-24" version="1">MKAVTWQGRRKIEVATVPDPQLVDPTDAVIEVTTTGLCGSDLHLYEVLGPFLDAGDILGHEPMGVVAEVGSEVRELKAGDRVVVPFNVSCGTCFMCERGLHSQCETTQVREHGSGASLFGYTKLYGQVPGGQAEYLRVPFADTLPIRVPEGPPDERFVYLSDVLPTAWQAVVYADVPPGGSVAVLGLGPIGDMCTRVAAHRGAGRVIGIDLVPERLARAAGHGVQVFDLSEYGDQLVDAVRGATGGRGPDAVIDAVGMEAHGGSAVKALQTATGLLPDAMASALMKKAGVDRLGALELAIELVRRGGTISLAGVYGGAADPLPLLTMFDKQIQLRMGQANVRRWVDDLMPLVTDGDPLGVEGFATHHLSLDDAPRAYADFQKKRDSMVKVLFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8J2</accession>
    <name>A0A0F4J8J2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_23360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949536.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene122"/>
    <dbReference type="EnsemblBacteria" id="KJY29276">
        <property type="protein sequence ID" value="KJY29276"/>
        <property type="gene ID" value="VR44_23360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.612"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470826" description="Histidine kinase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="220"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="46421" checksum="9C283452D5BDD774" modified="2015-06-24" version="1">MRRFTLRTGIRWKITLAIAAVGALTALALSLVVHSAARVSMLESARDSELERVQYIARTPDAGRKPIWGAKVNDPELPAELREKARSGRRGTYIQESPKRAPEVWAAVPLGNGQVLSMHHQFRESANMVRDLDRALVIGSLAVVIGGSALGVLIGGQISSRLRKAAAAAQRVAHGDPEVRVRDAVGGVVRDETDDLARAVDAMADALQQRLEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVRDRAQAMRALVEDVLEVARLDGASERAELQDVALGEFVTRRVTALMPEASVRVVADEIVSTDPRRLERILGNLLANAARYGQPPVQVDIEGRVVRVRDHGPGFPEALLREGPSRFRTGSTDRHGLGLTIAEGQARVLGARLTFRNVAAPGGADTEGAAAGAVAVLWLPEHAPTATGSFPIIQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8K6</accession>
    <name>A0A0F4J8K6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">VR44_20270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948966.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6973"/>
    <dbReference type="EnsemblBacteria" id="KJY30520">
        <property type="protein sequence ID" value="KJY30520"/>
        <property type="gene ID" value="VR44_20270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8762"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY30520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="31493" checksum="23CDEF5207AC08C7" modified="2015-06-24" version="1">MSWFESLILGLVQGLTEFLPISSSAHLRLTAAFAGWHDPGSAFTAITQIGTEAAVLIYFRKDIARIVSTWFRSLYTKSLRSEQDARMGWLVIVGSIPIGVLGVAFKDQITGPARDLRLTATTLIVMGLILGFADWLASRDEQGGRHRVVKQRKTLKELGVKDGLIFGVCQAMALIPGVSRSGATISGGLLLGFTREAAARYSFLLAIPAVLASGAFEIKDVIESPGHITWGPTIFATVIAFFVGYAVIAWFMKFISSKSFMPFVIYRILLGIALFVLIGMGVLEAEAGASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8R2</accession>
    <name>A0A0F4J8R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_23205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29346">
        <property type="protein sequence ID" value="KJY29346"/>
        <property type="gene ID" value="VR44_23205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.581"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="39651" checksum="5FA6368ED2299C09" modified="2015-06-24" version="1">MPRWLPRAVVLVLALVACFQLGSWAFHQLIGLLVNILIAFFLALAIEPAVARMAARGMRRGLATFLVFLGVFAAAAGFLALLGSMLAGQIVDMVEGFPHYLDMVIDSINRTFHTELSRLEIQDSLLHSDWLQKYVQNSASGVLDVSATVLGGLFRLLTVGLFSFYFAADGPRLRRALCSVLPPAKQSEVLRAWEIAVAKTGGYLYSRGLMALVSGIAHYVVFVVLGVPYAPALAVWVGLVSQFIPTIGTYLAGALPTLIAFTLDPWYAVYVLGFVVVYQQFENYVLQPKLTARTVDIHPAVAFGSVIAGTALLGAVGALIAIPAVATLQAFLGAYVKRYEVAGEAGGSAGGQAAGEATAARPRRVRLPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9B3</accession>
    <name>A0A0F4J9B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000537">
        <property type="protein sequence ID" value="KJY30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948829.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000537.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30785">
        <property type="protein sequence ID" value="KJY30785"/>
        <property type="gene ID" value="VR44_19505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8511"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10258" checksum="35CC86BD72F44FAD" modified="2015-06-24" version="1">MNSELPTGWTIERVRALSGDPSAISLSFDRLVVLEVAGQGDYEPLRPDVILAFHDLCLVRDDGEWFMGQLDDDGSVICWASYGSDLDKAIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBB4</accession>
    <name>A0A0F4JBB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948548.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000491.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31475">
        <property type="protein sequence ID" value="KJY31475"/>
        <property type="gene ID" value="VR44_18035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8153"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9951" checksum="B61841F44B75EDD7" modified="2015-06-24" version="1">MPGQRKRKAQKRREADALSARVAAGHWERRFETQDHDELRAYVAELARSGVRPDDTRIDMLCGRLVQPTWYVVSVLVPGPRPGPGPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBC1</accession>
    <name>A0A0F4JBC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_19065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948745.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000522.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31038">
        <property type="protein sequence ID" value="KJY31038"/>
        <property type="gene ID" value="VR44_19065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8417"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24025" checksum="60D1F579C88643FC" modified="2015-06-24" version="1">MRIPAHAVCTAIRDDIVSGFFGPGGRLTEEVLARRYGVSRVPVREALRTLESEGFVTTRRHAGACVAEPGEQEAADLLELRTLLEPLAAARAARRRTEAHLKVLRGLVRLGQERARRGQGEDLRALGSWFHETLAQASGSPGLITLLTQTRHKIAWLYEVRAPARPVDSWADHGAVVDAVARGDAERARALTALHAERTAGAFRLRVRGLQPAVNTGGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBN4</accession>
    <name>A0A0F4JBN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDPG_MGDP_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000468">
        <property type="protein sequence ID" value="KJY31772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31772">
        <property type="protein sequence ID" value="KJY31772"/>
        <property type="gene ID" value="VR44_17500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="19848" checksum="3CB7479A7D6CCDBC" modified="2015-06-24" version="1" fragment="single">MGRLGVPYLTALAELGHEVLGLDINPETLEALQDGRCPFDEPGITDYIAKHTAAGRLRFTDSYDEAAAHGDVFFLAVPTPQREGAMTMDLSAVEDAIGALACRLTRPAVLIGKSSLPVGESVRLAALAADQAPNGVQLRVGWSPDFLREALSMETTLHPARLVLGASDADRAVVESTARRVWAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC64</accession>
    <name>A0A0F4JC64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000499">
        <property type="protein sequence ID" value="KJY31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948614.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000499.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31343">
        <property type="protein sequence ID" value="KJY31343"/>
        <property type="gene ID" value="VR44_18380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8225"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="35423" checksum="67D26487E80B81FB" modified="2015-06-24" version="1">MAALGWLTPRRRSATARSVLAGEASAEAARKTARSDAPPHPAPAAPQAPETASGTGTDITAPPAEAAAEPAFPVPGDDLAAAFFDLDNTVMQGAAIFHFGRGLYKREFFRRRELARFAWQQAWFRLAGVEDPEHMQDARDSALSIVKGHKVSELMSIGEEIYDEYMAERIWPGTRALAQAHLDAGQKVWLVTAAPVETATIIARRLGLTGALGTVAESVDGVYTGRLVGEPLHGPAKAEAVRALAAAEDLDLARCAAYSDSHNDIPMLSLVGHPYAINPDTKLRKHARAHDWRLRDYRTGRKAVKVGVPAAAGVGAIAGGAAAAIALHRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCB0</accession>
    <name>A0A0F4JCB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948587.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31393">
        <property type="protein sequence ID" value="KJY31393"/>
        <property type="gene ID" value="VR44_18240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8195"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="14973" checksum="778045E7D45DE944" modified="2015-06-24" version="1">MTTTFEAEWASLKQQAASRTEMHLASAAAAGGGGGGEDLKSDKAVWNRASQDLGGLATNIKTALTGLGDGQKGAAQAGVESSAAQDELYQSWKTYLESLAGKCSALQGPLRKAGEGQYANDEAIKDGFTQVDGQYQDTPATGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD07</accession>
    <name>A0A0F4JD07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000442">
        <property type="protein sequence ID" value="KJY32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32080">
        <property type="protein sequence ID" value="KJY32080"/>
        <property type="gene ID" value="VR44_16715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7777"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="35636" checksum="F128E2099DB909FC" modified="2015-06-24" version="1">MPQLTDDPGRKGTWMTPAEYGASRAALWTGAVVLVTDTDGRVLVQSVDYRPDRLLPGGAVDAGEAPAAAAAREVREELGVDGHYPCGLAVDWIPADTPGFPAEMRFPGEILHVYDGGTWAPDRIESIRLPAQEITGIEFAEPADLTALMEPGDARRALAALRARINGSGPALLEDGRPTVPTALDRLGVLRTRRVPQHGTWHPGPVPARLPVRGHSGWLFAPDGRVLLLVARATGAAHLPAPKAEPAVGALPLGYRYADRTALARTAARLTGLAPAGDPAYARLLATPEQVRELSDWGPAGRQEVAAVHAARTRLGLPVPLRTPPTELPEQGLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDY3</accession>
    <name>A0A0F4JDY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000452">
        <property type="protein sequence ID" value="KJY31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31948">
        <property type="protein sequence ID" value="KJY31948"/>
        <property type="gene ID" value="VR44_17075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="30853" checksum="1096A8DF4D5066A6" modified="2015-06-24" version="1" fragment="single">PPPTAAPAAGYRAVFRVPEFPAVFAAHLMSVLGVVVAEISLTVLVYRATGSPLMSALTFALGFLPYALGGTVLAGIADRHPARRVLTACDLVCAACAAAMVWPGTPVAGILVLRCAMAFVAPLFQGARSASLADILGSGEAFVLGRSLLRMVAQSAQLTGFGLGGLLLTVLAPRGAIALTAAGFLASALLLRLGTRPRPARAGAVRHSALGGLRAVFGNRRLRALTLLCWIPSAFSVVPEALLTPYADGIGAGTVTLGILMCALPVGTIAGELWAGSALTPRTRARITAPLAAVCLLPLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEW9</accession>
    <name>A0A0F4JEW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947969.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32897">
        <property type="protein sequence ID" value="KJY32897"/>
        <property type="gene ID" value="VR44_14945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7405"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="30392" checksum="E292F8362A213379" modified="2015-06-24" version="1">MKKTAVVTAGTGGIGLETALGLAAAGFAVTVVGRDAGRGAGAVERINAAGPAHPARFLPADLASLDQVRALARTIADDHAASGEPLTVLVNNVGAMFAERQTRGGVEASFVVNHLSPYLLTELLLPTLTAGAPSRIVNVTSGAVTVAKRVFDAVEPPGGYYGFHWYGRAKLANLAYTLDLADRLDGTGVSVFAADPGGAATDMTDGTMTDPKIVSPALRLLWPLVRRTFERSTSGPASAAARPSLTAATDETLTGRTGIVIGAQAHPVAPHRAAADPRVAEAVRRLSERHAPLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF83</accession>
    <name>A0A0F4JF83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000413">
        <property type="protein sequence ID" value="KJY32418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948163.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000413.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32418">
        <property type="protein sequence ID" value="KJY32418"/>
        <property type="gene ID" value="VR44_15985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7617"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="524" mass="52110" checksum="FDBDDD6EB86461D5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFF0</accession>
    <name>A0A0F4JFF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948138.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32483">
        <property type="protein sequence ID" value="KJY32483"/>
        <property type="gene ID" value="VR44_15855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7579"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="38670" checksum="26D1FCDE9E1562A3" modified="2015-06-24" version="1">MPLSPLPAARTTVFAPRLAALLREYTGEDAFRLEPDTMGVAGHALADRILAARRATETERPTFKPLHGRSIGRTEAAAVMRVIGRDVREALEGPLPKEVDLTGPWPLTGHLFLRDLILGGDPRRLRILMSRNLELTPKLTWSVIAAGAAVPWRKKPGTTSSGIAGLLAEADGYHDRRHAMGIYRRAAAPVCFTVSTLVANALWLGSPFDADTPNRNILHEAARLLPPSWNILRYASPEYGALDARIGAGDDVLVLPLLSHRDPALWEEPDAFRPGRWDRLDPETAPGYLPFGHSSERCWGRHMVMPLAELLLDLIRGTGLEVDPAQRKAKVPLVGLLGVEDVRLTKAARRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFY3</accession>
    <name>A0A0F4JFY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000368">
        <property type="protein sequence ID" value="KJY33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33252">
        <property type="protein sequence ID" value="KJY33252"/>
        <property type="gene ID" value="VR44_14265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6422" checksum="B7ED6842961299F1" modified="2015-06-24" version="1" fragment="single">MSLRRGRRLAIDVGDARIGVASCDPDGVLATPVETVPGRDVPAAHRRLRQLVAEYEPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG85</accession>
    <name>A0A0F4JG85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="5" type="ORF">VR44_14110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947825.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2581"/>
    <dbReference type="EnsemblBacteria" id="KJY33362">
        <property type="protein sequence ID" value="KJY33362"/>
        <property type="gene ID" value="VR44_14110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7136"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11565" checksum="BF2286E1E627A35A" modified="2015-06-24" version="1">MYAIVRSGGRQHKVAVGDIVEVDKISTAKVGDTVELSTLLVVDGDAVTSDPWVLAGIKVQAEVVDHHKGAKIDILRYKNKTGYRRRQGHRQQYTAIKVTGIPTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGQ0</accession>
    <name>A0A0F4JGQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000353">
        <property type="protein sequence ID" value="KJY33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33517">
        <property type="protein sequence ID" value="KJY33517"/>
        <property type="gene ID" value="VR44_13765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7031"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="18086" checksum="0EE7C5E36FBD1FA0" modified="2015-06-24" version="1">MLELLSADGPDPDHAEAMMLYGRLVGTWDISNRYRSSGGKWRTAAGEWRFGWVLGGRAVQDVLFCPEFHDRFPGTTVRMYDVTTGLWRITWISPKLPSYFAQTGRSDGAGGMIQEGVDSEGTRSRWTFTDVTPASFHWQGFSAPPDGEFELFQEMHATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH87</accession>
    <name>A0A0F4JH87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="8" type="ORF">VR44_14365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947868.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3331"/>
    <dbReference type="EnsemblBacteria" id="KJY33169">
        <property type="protein sequence ID" value="KJY33169"/>
        <property type="gene ID" value="VR44_14365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7222"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="38119" checksum="59A1C2087E84EA7D" modified="2015-06-24" version="1">MNWDDDSTTPEPDRLVAAAADGEDTAVEAALRPKDLGEFVGQEKVRQQLDLVLKAARQRGATADHVLLSGAPGLGKTTLSMIIAAEMGAPIRITSGPAIQHAGDLAAILSSLQEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATAIPLELPPFTLVGATTRAGLLPPPLRDRFGFTGHMEFYAPEELQRVVHRSARLLDVEIDTAGAAEIAGRSRGTPRIANRLLRRVRDYAQVRADGVITREVAATALQVYEVDARGLDRLDRAVLEALLKLFGGGPVGLSTLAVAVGEERETVEEVAEPFLVREGLLARTPRGRVATPAAWAHLGLVPPQQQAGGSSGQQGLFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIB0</accession>
    <name>A0A0F4JIB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947767.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33498">
        <property type="protein sequence ID" value="KJY33498"/>
        <property type="gene ID" value="VR44_13805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7040"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="23040" checksum="8E8DE6DF662D1C03" modified="2015-06-24" version="1">MPTKRSYVSPRREQAAAHTRELILRSATGLFADRGYGRVTVGDIAAGAGVSPKTVFASLGSKSDILNEIVDAAVRDSGHERALRSVRVAQDPVAVLEAVARGTRTGNESKYAVHEAIRKALPSHEDGEVLWERATADYRAALREAARRLHALASLPYSQEETADLLWFWFGPAGWRTLVAEAGWSWDRAQEFLLRTATVTLHAPSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIT6</accession>
    <name>A0A0F4JIT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947707.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000345.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33683">
        <property type="protein sequence ID" value="KJY33683"/>
        <property type="gene ID" value="VR44_13460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6942"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="40987" checksum="88A56B193987E869" modified="2015-06-24" version="1">MSRRGLAAVSSVLDQAASSATNILVLVLAARLSSASGFADFSMVYVTFSVLLGLNMAYVGQTVVLEKEAGGRLGVTCRSSVLFTAAAAGVAGLVLGVVSLVLPSGWAFLALGLVLPFVLVQDGLRYCFSALRVPERALAADTLRLVCVVAALAVQPQGASAGRLVLVWGLSALPALGLGLWLLRPYVRGARADVRPYLRRGHLGQRFVVEFAVGNGSSQLAVLGLGAFATPLAVGALRGATTLFGPLNVLFNSANAFGPPIVGRASGKRGMVRLTAAMGAALALLGAGWAAVLYALPEGLGRHLLGDTWTAASALLPATGAQYAVMGLGTCALLTLRVLNPKATLSLQVVFSLLSVALLLGGYAAWGVTGAAWGLAAGSAAKATAGWLRVGRVRVEAEAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIU6</accession>
    <name>A0A0F4JIU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_13470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947717.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000345.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3036"/>
    <dbReference type="EnsemblBacteria" id="KJY33693">
        <property type="protein sequence ID" value="KJY33693"/>
        <property type="gene ID" value="VR44_13470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6944"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="401" mass="41711" checksum="143498E8FE9693F1" modified="2015-06-24" version="1">MVSTNYAPEHAGIGPYATQIAEHWASSGHDTHVLAGMPHYPAWSLEPEYKGALRRTERRAGVTVHRRAHTVPAHQTAVKRALFEGSILLHGAVAPPRMPRPHAVMAQMPSLAGGVLAARLAARWKVPFVPVVQDLMGAAAAQSGISGGDKAAALAGRAEAYALKRAALVGVIHETFVDRVVGMGVDPQRIRVVPNWSHVPGPTKPRGETRHHLGWAPDQTVVLHSGNMGLKQGLEVLVGAARLDPRVRFVLMGDGSQRAALAALAADVPNLEIIPPAADGEFPDILAAADVLAVTQHAAVLDMSVPSKLTSYFQAGRPVVASVAAQGGTAQEVERSGAGVLVPPEDPEALLGAVRALAEDPEGADALGAAGPVHVAAHLSREAGLARIDALIDEALGGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJA6</accession>
    <name>A0A0F4JJA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947629.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33894">
        <property type="protein sequence ID" value="KJY33894"/>
        <property type="gene ID" value="VR44_13060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6731"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="27788" checksum="CD258957B30EA821" modified="2015-06-24" version="1">MTTTVLITGASAGLGAAFARGFAAKGCALVLVARDKTRLEALAAELARDFGTVCEVLPADLLDPAGCGAVADRLADTARPVDVLVNNAGFGLPAPYPYSPLEDEERMLDLLVKVPLRLTHALLPGLRERRRGAVLNVSSVAGLLPTGTYGAAKAWLTAFSESLRIDMAPYGVRVLAVAPGFTRTELHQRAGMDVSSLRDGVWLEPEAVVAKALRDLALRRPVSITGRHYQAYAFAARHLPRAFVAGRMARKRRAPGDPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJM6</accession>
    <name>A0A0F4JJM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_14405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947875.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33176">
        <property type="protein sequence ID" value="KJY33176"/>
        <property type="gene ID" value="VR44_14405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7230"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="31483" checksum="7CEB76C38E1D7C93" modified="2015-06-24" version="1">MYGLGWAGVKKLPEPVAAALGRKIADVAWKRRGKSVLRLESNLARVVPDAGPERLRALSQAGMRSYMRYWMESFRLPAMDPRRFGTDVSIKDEHILREALASGRGVIVALPHLANWDLAGAWVTGHVGVPFTTVAERLKPESLYDRFVAYRQSLGMEVLPHSGGAAFGTLARRLRSGGLICLVADRDLSSSGVEVDFFGATARMPAGPALLAQQTGAALLPVTLSYGDAPKMYGRIHPEVEVPGTGTRAEKTAAMTQSVADAFASGIAEHPEDWHMLQRLWLDDLEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJY9</accession>
    <name>A0A0F4JJY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000314">
        <property type="protein sequence ID" value="KJY34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1452"/>
    <dbReference type="EnsemblBacteria" id="KJY34083">
        <property type="protein sequence ID" value="KJY34083"/>
        <property type="gene ID" value="VR44_12645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6594"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11870" checksum="A63B6E6BBF527ECD" modified="2015-06-24" version="1" fragment="single">ARDALLPISVAEHAARLGVPLPELRGAVRRSTGAGVKEYLLGIRLTRAKELLARTDLPVAGIARRVGYEDPAYFSRLFSRRVGMAPVRFRAQQSVRGAGCGGGAQGMGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKP6</accession>
    <name>A0A0F4JKP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000353">
        <property type="protein sequence ID" value="KJY33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33516">
        <property type="protein sequence ID" value="KJY33516"/>
        <property type="gene ID" value="VR44_13770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7032"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18670" checksum="CB775A8E68C55ECE" modified="2015-06-24" version="1" fragment="single">GDTCPDNSLITPEGLRLIDFEAACYQSVFLTAAYCRMPFSSCWCVFALPAGMAAEIEQAYREEVVGVYPALAEDEVWQAGMRQATAVWTVDATVRLLPRVMEDGPLHPTRRPAPTRRQVLRHRWETASGLEEYPALAETMRSLLREVAGTWEVAPLPPYPAFANRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLF0</accession>
    <name>A0A0F4JLF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000239">
        <property type="protein sequence ID" value="KJY35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947182.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000239.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35172">
        <property type="protein sequence ID" value="KJY35172"/>
        <property type="gene ID" value="VR44_10655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5878"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471155" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8418" checksum="E9439B2C5EF40AF2" modified="2015-06-24" version="1">MKGRLAFAALAAAVVAVLPAAAPAQAAPAQPSGDCAALISLISDPNVSVQEKKQAGRDYVNTHTRDEIDQCRRSYQGGIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLH4</accession>
    <name>A0A0F4JLH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947656.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000336.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33816">
        <property type="protein sequence ID" value="KJY33816"/>
        <property type="gene ID" value="VR44_13190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6856"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471157" evidence="1">
        <location>
            <begin position="28"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="41941" checksum="D30EDDB8B67890D3" modified="2015-06-24" version="1">MKARTRTLVAAALVLGIAAGPVAAAQAAPARSQTPVAAPVPSPVFSAPPDAAALRKAIAGVGPQNKDATAALVRVGGTSGSWRGSAGVADVRDGRAAVEDARFRAGSVTKTFTAAVVLQLAAEGKVDLDRPVQDYLPGLLPGFEPVKVRQLLNYTSGLRSADGPGDAFEDEYAHRFDLVDPHALIANAVAKGPESAPEKQQRYSNIHYTVLGVLIEKLTGTTYEKAVGERIIKPLGLRHTSFPSRTQNRIPGPYNHGYQAVQAADGSRSLVDVSDWNSSSNWAAGDLISTTADLERFTVALFGGRVVPKAQLEEMFTVPDVPDAETGEHAVQTAGLKEFVLPDGTKLYGKTGSRYGYSTVIGGTRDLSRTLVYSVNSTDAKGRDMNAVAYGIIGAAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM55</accession>
    <name>A0A0F4JM55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000319">
        <property type="protein sequence ID" value="KJY34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947584.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000319.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34016">
        <property type="protein sequence ID" value="KJY34016"/>
        <property type="gene ID" value="VR44_12815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6644"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="76"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="34629" checksum="2730CB3C26D3DE3C" modified="2015-06-24" version="1">MSRARTARRIAAGAAYGGGGLGLVGVAAVGLVLAEVQFAKRTVGTGLPDPPRADGLYGSEFGGPELSPGPLRMAMLGDSTAAGLGVRRARQTPGALLASGLAAVAERPVELRNVALSGAMSDDLDRQVSLLLDGDGPAPDVSVVIIGANDVTRRMPLTQSVRLLTAAVRRLRLAGSEVVVGTCPDLGTIEPVYQPLRWMARRVSRQLAAAQTIGVVALGARTVSMGDMLGPEFAANPREMFGPDSYHPSAEGYATAAMAVLPTLCAALGVWPESDRLDVSRNEDMLPVAKAASAAAGEPGTEVTAARGPWALLKHRRRRRLPAEPVPEPAAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMT5</accession>
    <name>A0A0F4JMT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000207">
        <property type="protein sequence ID" value="KJY35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946967.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000207.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35677">
        <property type="protein sequence ID" value="KJY35677"/>
        <property type="gene ID" value="VR44_09490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5299"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="41697" checksum="004BEC313B6205F4" modified="2015-06-24" version="1">MSARTLVTGIGVAAPSGLGVEDFWAATRIGKNAIGPVTRFDASSYPSRLAGEIHGFEPAEHLPGRLVPQTDRVTQLALVATDCAFEDAGLDPGDLHPCDMGVVTAAGSGGSEFGENELRKLWSQGPKHVSAYQSFAWFYAVNTGQIAVRNDLRGPTGVLVGDQAGGLDALAQARRRLRKGSRLIAAGGFDASICSLGWAAHLAAGDLSVSEVPERAYLPFDAAASGYVPGEGGALIILEDEEGAVARGARDAYAEFAGYGATLDPRPGSGREPGLRRAVLAALADAGCHPAEVDVVFADGAGVPRLDREEAEAITAVFGPLGVPVTAPKTTTGRIGAGGAPVDVVSAVLSMREGLIPPTTNVELSPAYDIDLVAVRPRTASVRTALVLARGRGGFNSAVVLRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN17</accession>
    <name>A0A0F4JN17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000295">
        <property type="protein sequence ID" value="KJY34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947452.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000295.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34336">
        <property type="protein sequence ID" value="KJY34336"/>
        <property type="gene ID" value="VR44_12095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6505"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7484" checksum="5E8B9FEEF0172647" modified="2015-06-24" version="1">MAGIGGCITLIVVGAILTFASDWHMDGVNLDVVGLIMMAGGLLGLAVYSSVLRRRRAAALPVVDETRDDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN46</accession>
    <name>A0A0F4JN46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HopJ type III effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000239">
        <property type="protein sequence ID" value="KJY35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947183.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000239.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35173">
        <property type="protein sequence ID" value="KJY35173"/>
        <property type="gene ID" value="VR44_10665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014984">
        <property type="entry name" value="HopJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038604">
        <property type="entry name" value="HopJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08888">
        <property type="entry name" value="HopJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12003" checksum="3A37A3FDFCF599BB" modified="2015-06-24" version="1">MTDLNSLRASLASGEHEFADTLAFVAAHYEYQPQAFRNGEVENGAGENEGSCKTLGLALLEGLSDQEALLAFGEHYRDVLATPEGSDHGNIRNLMAHGLAGVSFAGQPLTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNB5</accession>
    <name>A0A0F4JNB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_09435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000206">
        <property type="protein sequence ID" value="KJY35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946956.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000206.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35685">
        <property type="protein sequence ID" value="KJY35685"/>
        <property type="gene ID" value="VR44_09435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5287"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29887" checksum="21DC8814C7222418" modified="2015-06-24" version="1">MDIDVLGALTVRENGVSITPTAAKPRQVLALLALHADQVVPVAALIEELWGTEPPRSARTTLQTYVLQLRGLISQALEGTDGSRTAKDVLVTLPGGYMLNSGGGTSDVREFDRLAGMGYRAMDAGDFPTAARLLREALALWSGQAFADVDGGVQLDMETRRLEETRLCALDQRIEADLRLGRHRELLAELTVLASRYRIHENLHGQFMLALHRSGRRGEALSVYQRLRSTLVRELGIEPSAALRSLQRSILMSSPESPAESPETARKRLARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNK3</accession>
    <name>A0A0F4JNK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase expression protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946909.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35785">
        <property type="protein sequence ID" value="KJY35785"/>
        <property type="gene ID" value="VR44_09190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5102"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1040" mass="107744" checksum="8EB699FA0C8C7BAF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP84</accession>
    <name>A0A0F4JP84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000173">
        <property type="protein sequence ID" value="KJY36182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946768.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5015"/>
    <dbReference type="EnsemblBacteria" id="KJY36182">
        <property type="protein sequence ID" value="KJY36182"/>
        <property type="gene ID" value="VR44_08420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4584"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="36296" checksum="9C3B39872FD122B4" modified="2015-06-24" version="1">MTRNDKNPHAVEVRGLVKHYGDTKALDGVDLFVREGTVLGVLGPNGAGKTTLVRCLSTLIVPDAGTATVAGYDVVRQPRQLRRTIGLTGQYASVDEKLSGWENLYMIGRLLDLSRSEARSRADELLERFSLTEAAKKAAMHYSGGMRRRLDLAASMIGRPAVLYLDEPTTGLDPRTRNEVWDEVQRMVAEGATVLLTTQYMEEAEQLASELTVIDRGKVIANGKVDELKARVGGRTLRIRPVASADLPDMARALSETGLDGVAGAQAVPDEGVLLVPILSDEQLTAVVGLLAGRGYAIADLGTYLPSLDEVFLSITGQRPTPSEDSVPTEKTEEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPS8</accession>
    <name>A0A0F4JPS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000194">
        <property type="protein sequence ID" value="KJY35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946887.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000194.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35854">
        <property type="protein sequence ID" value="KJY35854"/>
        <property type="gene ID" value="VR44_09045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5072"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_oxred_C" evidence="1">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="42531" checksum="5E132B675C0D9FB0" modified="2015-06-24" version="1" fragment="single">GGMAPTPRRSYFAEVLPQVDAEEMYGTYYPRARAMLGVNTVDPDWFESTEWYRFARVSRKHAQNTGLRTTFVPNVYDFGYMRREAAGTATRSALAGEVIYGNNHGKQSVDKTYLAAALGTGNVTIETMQRVVAVRQDPAGGYVLTVRTSDITGKVTQVRELGCDRLFLGAGSLGTTEILLRARETGTLPALSDRVGQGWGTNGNVMTARANHLWDTVGANQATMPALGIDDWDNAANPVFAEIAPLPMGIEHWISMYLAITKNPERGHFTYDAATDSARLRWTRDQNAPSVAAAKNLFDRINLRNVTMYRYDLFGENKAFADTFTYHPLGGCVLGEATDGYGRVKGYRGLYVTDGSLVPGSLGVNPFLTITALAERNMERILAEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQG7</accession>
    <name>A0A0F4JQG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000238">
        <property type="protein sequence ID" value="KJY35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947178.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000238.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35181">
        <property type="protein sequence ID" value="KJY35181"/>
        <property type="gene ID" value="VR44_10625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5869"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="12983" checksum="19178024961BD138" modified="2015-06-24" version="1" fragment="single">FAESVLAPHTPGPPQHRHAQHDEGFYILSGTVRFTVGHDSHDAPAGTLVVVPPGAPHTFANVTDQPAVMLSTFTPGRYVQYFRDLQDMLTDGRPLTPEANIAAMSPYATHPATDFPAAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR97</accession>
    <name>A0A0F4JR97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946505.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36892">
        <property type="protein sequence ID" value="KJY36892"/>
        <property type="gene ID" value="VR44_07005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3615"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="548"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="603" mass="63344" checksum="75EA85DB27181080" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSS6</accession>
    <name>A0A0F4JSS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_06990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="KJY36889">
        <property type="protein sequence ID" value="KJY36889"/>
        <property type="gene ID" value="VR44_06990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3612"/>
    <dbReference type="eggNOG" id="COG3707">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
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    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="4">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23973" checksum="1EC05D99FB8C0388" modified="2015-06-24" version="1">MTAEHESTPTPDADQSHVPPLTTRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQTAVELAREHRPDLVILDVKMPVLDGISAAEKIAGESIAPVLMLTAFSQRELVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRFAELKALEKEVADLSARLETRKLVDRAKSILQTQYGLTEPAAFRWIQKTSMDRRMSMQQVAEAVIEDAEEKKQNAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT31</accession>
    <name>A0A0F4JT31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="9">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_08495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946781.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36121">
        <property type="protein sequence ID" value="KJY36121"/>
        <property type="gene ID" value="VR44_08495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4762"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="13">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="12">
        <location>
            <begin position="239"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY36121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="834" mass="87614" checksum="C23964A515AE8242" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTE4</accession>
    <name>A0A0F4JTE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">VR44_05675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946256.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2523"/>
    <dbReference type="EnsemblBacteria" id="KJY37425">
        <property type="protein sequence ID" value="KJY37425"/>
        <property type="gene ID" value="VR44_05675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1950"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="27021" checksum="568BD6A8C70C8E11" modified="2015-06-24" version="1">MSLFRDDGIVLRTQKLGEADRIITLLTRGHGRVRAVARGVRRTKSKFGARLEPFSHADVQFFARGSELVGRSLPLCTQTEIIAPYGNGIVTDYARYTAGTAMLETAERFTENEGEPAVQQYLLLVGALRTLSRGEHEPHLILDAFLLRSLAVNGYAPSFEDCAKCGIHGPNRHFSVAAGGVICGDCRVPGSVVPSAEAIGLLSALLTGDWPTADAAEPRHVREGSGLVSAYLHWHLERGLRSLRYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTJ1</accession>
    <name>A0A0F4JTJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946394.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37149">
        <property type="protein sequence ID" value="KJY37149"/>
        <property type="gene ID" value="VR44_06405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13705" checksum="F19DCF5E5E60EA33" modified="2015-06-24" version="1">MTIDWHSLPPQQEPAHIPVLTPDAHHAVDWDRVRATIRRLRPLRALAVTAVGLYPAVMWCNRIAGPLAAERGVHTAFAAGAITTVVCAVGVASGGGLRRWIAGLGLVGAMGGTLLADPTRHLVVTWIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU35</accession>
    <name>A0A0F4JU35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acyl-D-glucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946187.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7125"/>
    <dbReference type="EnsemblBacteria" id="KJY37675">
        <property type="protein sequence ID" value="KJY37675"/>
        <property type="gene ID" value="VR44_05340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1704"/>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="607" mass="69426" checksum="C0685FAD742C33BB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV54</accession>
    <name>A0A0F4JV54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946152.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene155"/>
    <dbReference type="EnsemblBacteria" id="KJY37724">
        <property type="protein sequence ID" value="KJY37724"/>
        <property type="gene ID" value="VR44_05105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1336"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24220" checksum="C2D974889A1A7A61" modified="2015-06-24" version="1">MAVRNCLVANDWICWDYVTSRAPELADATLEHVWITAVSVLIGVAVSVPLALLARRGRRWAAPVLGLTTLLYTIPSLAMFSLLLPLFGLSAALVVTGLVLYSLTILVRNVLAGLEAVPEEVREAARGMGYGPARLLWQVELPLALPALLAGVRIATVSTVALTTVGSIVGKGGLGNLIAPAVSSSFKAQVLTASVLCVLLALVADLLLLGLQRMLTPWTRAGRPVRVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWB5</accession>
    <name>A0A0F4JWB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818984.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5798"/>
    <dbReference type="EnsemblBacteria" id="KJY37281">
        <property type="protein sequence ID" value="KJY37281"/>
        <property type="gene ID" value="VR44_06115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2559"/>
    <dbReference type="eggNOG" id="ENOG5032YSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7687" checksum="6892B6D01F7B3D9C" modified="2015-06-24" version="1">MTEATDLAERAGDRDPRVGLRAVAALRRLLEQLEAVQVRSARAQGWSWQEIAAELGVSRQAVHKKHGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWN6</accession>
    <name>A0A0F4JWN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="14" type="ORF">VR44_04075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="JZWV01000075">
        <property type="protein sequence ID" value="KJY38153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945963.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene731"/>
    <dbReference type="EnsemblBacteria" id="KJY38153">
        <property type="protein sequence ID" value="KJY38153"/>
        <property type="gene ID" value="VR44_04075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8720"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="118"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY38153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="40971" checksum="6F5FC8E8BA56243B" modified="2015-06-24" version="1">MAPRPAPGELTFVAPRGAKKPPRHLADLTPAERREAVAAIGEKPFRAKQLSQHYFARYAHDPAEWTDIPAASREKLQQELLPELMNVIRHISCDDDTTRKTLWKLHDGTLVESVLMRYPDRVTMCISSQAGCGMNCPFCATGQAGLDRNLSTAEIVHQIVDGMRALRDGEVPGGPARLSNIVFMGMGEPLANYNRVVGAIRRLTDPEPDGLGLSQRGITVSTVGLVPAMLRFADEGFKCRLAVSLHAPDDELRDTLVPVNTRWKVREVLDAAWEYAEKSGRRISIEYALIRDINDQAWRGDLLGRLLKGKRVHVNLIPLNPTPGSKWTASRPEDEKAFVDAIARHGVPVTVRDTRGQEIDGACGQLAASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWV1</accession>
    <name>A0A0F4JWV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_03200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38615">
        <property type="protein sequence ID" value="KJY38615"/>
        <property type="gene ID" value="VR44_03200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7855"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21840" checksum="415442FF6F334276" modified="2015-06-24" version="1">MPSPREDAEQAGGAAAAGAPTGDGAEGAAGSAADAPQVVAGTTVDHLTETYQAHYRSLLGLAALLLDDTASCEDVVQEAFIRVHSARNRVRDRDKTLAYLRQTVVNLSRSALRRRILGLKLLSKPMPDMASAEEGAYDQLERDDLIKAMRGLQRRQREVLVLRYFADMTEAQVAETLGISLGSVKAYGSRGIAALRVAMEAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX60</accession>
    <name>A0A0F4JX60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inosine-5-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_05445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000099">
        <property type="protein sequence ID" value="KJY37566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946215.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7144"/>
    <dbReference type="EnsemblBacteria" id="KJY37566">
        <property type="protein sequence ID" value="KJY37566"/>
        <property type="gene ID" value="VR44_05445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1725"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="487" mass="51632" checksum="A1CB08C2590DB2C9" modified="2015-06-24" version="1">MDWDVQHVRFLNDLKPPYDLTYDDVFMVPSRSAVGSRQGVDLASPDGTGTTIPLVVANMTAIAGRRMAETVARRGGIVVIPQDIPIEVVTDVISWVKTRHLVLDTPITLAPTQTVADALSLLPKRAHGAGVVVDADHRPVGVVTDHDLTGVDRFTQLSEVMSKELLLIDADIDPREAFNQLDAGHRKLAPAVDKDGRLVGILTRKGALRATLYTPATDANGKLRIAAAVGINGDFVGKAKQLLDAGVDTLVIDTAHGHQESMINAIKAVRALDPQVPIVAGNIVAAEGVKDLIDAGADIIKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEAKKYGKHVWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQQSAEGRLYKESFGMASARAVRNRTSEESAYDRARKALFEEGISTSRMFLDPARPGVEDLIDSIIAGVRSSCTYAGAASLAEFEEKAVVGIQSAAGYAEGKPLHASWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXE4</accession>
    <name>A0A0F4JXE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945657.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39032">
        <property type="protein sequence ID" value="KJY39032"/>
        <property type="gene ID" value="VR44_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="20993" checksum="E90622F9C3153E90" modified="2015-06-24" version="1">MDDRTTGRRSNPLRRKADRTRTRLHAAFAVACLIAVVCGVAVGRAAWSDSSRAAESAARHRHDVPAVTVGRTTYRAGDEPDGTPVTVAPATWRYPADRAHTDTLPVPVGTRQGDTVRVRVDDSGNPAGSPPGTVEIGLDAFGLGTGPLTGVLLVSGLLVRLGLRIVDARSSRAWETEWEGVEPLWSGRLRPGQGADDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXH5</accession>
    <name>A0A0F4JXH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000061">
        <property type="protein sequence ID" value="KJY38529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6628"/>
    <dbReference type="EnsemblBacteria" id="KJY38529">
        <property type="protein sequence ID" value="KJY38529"/>
        <property type="gene ID" value="VR44_03440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7905"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOP1Ac" evidence="2">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="524" mass="55950" checksum="68AFCFBF4B788E40" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXT2</accession>
    <name>A0A0F4JXT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945853.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6626"/>
    <dbReference type="EnsemblBacteria" id="KJY38543">
        <property type="protein sequence ID" value="KJY38543"/>
        <property type="gene ID" value="VR44_03425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7902"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="160"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="504" mass="54040" checksum="004E15CB6BB8BE88" modified="2015-06-24" version="1">MSTTSLPQPDRAAELREAFLAAGFTADGLLDLLGAPAYAALARSETVPALRATRSHGDGPLATLVRLFLLQCPVPHAHAAQALPVEAALADGWLRREGDEVHATVDVRPYGGPDGEDWFIVSDLGCAVGGAGGIGSREEGVVLGVGGASTTLAGITVRTPVGSALDLGTGSGIQALHAAQHATRVTATDVNPRALEFTRLTLALSGAPEAELLTGSLFEPVGDATYDLIVSNPPFVISPGARLTYRDGGMGGDDLCRTLVQQAGDHLNPGGFAQFLGNWQHVEGEDWHDRVRSWVPRGCDAWIVQRDVQDVTQYAELWLRDAGDHRTDPAEYAARYEDWLDEFESRKTKAVGFGWITLRRTDAAEPSIVVEEWPHSVEQPLGETVLAHFARQDYLREHDDAALLAGYFQLTEEVVQEQVGAPGAEDPEHVVLRQNRGMRRATKVDTVGAGFAGVCDGSLSAGRILDAIAQLVDEDPVLLRDRTPEAIRMLVEQGFLEPVPGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ85</accession>
    <name>A0A0F4JZ85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945648.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39023">
        <property type="protein sequence ID" value="KJY39023"/>
        <property type="gene ID" value="VR44_02330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6756"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="13480" checksum="5D54DB2432845378" modified="2015-06-24" version="1">MNYYLDVIKRYADFQGRARRQEYWMFLLWNIPIVIVLTILDYALGSYPVITWIYTLAVFLPSLGVSVRRLHDTGKSGWWYLVSLIPFIGFIWMIILMATEGDAGPNAYGPSPKQIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZW8</accession>
    <name>A0A0F4JZW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945822.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6589"/>
    <dbReference type="EnsemblBacteria" id="KJY38561">
        <property type="protein sequence ID" value="KJY38561"/>
        <property type="gene ID" value="VR44_03250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7865"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="33828" checksum="10E5E656BCC0F5DA" modified="2015-06-24" version="1">MRARYGVPLKVTAGIAAVGAAGVAYAAGFEARSFRLRRVSVPVLPAGARPLRVLQVSDIHMVGGQRKKRAWLQSLAGLRPDFVVNTGDNLSDTEGVPELLDALGPLMEFPGVYVFGSNDYYGPRLRNPGRYLIEKAQGRHGLNGNKPVVGAVHNPWEGMRDAFDAAGWLNLTNTRGRLKLGGMELAFTGLDDPHIKRDRYERVAGGPEADADFSIAVVHAPYLRVLESFTADRYPLILAGHTHGGQLCVPFYGALVTNCDLDTKRVKGLSTYETQGERSYLHVSAGCGTNRFTPVRFACPPEATLLTLTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZX3</accession>
    <name>A0A0F4JZX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945349.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39695">
        <property type="protein sequence ID" value="KJY39695"/>
        <property type="gene ID" value="VR44_00705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2846"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="28723" checksum="3556A455716C5B97" modified="2015-06-24" version="1">MGVLKRFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNATIWNRERTVVPNDFIVELSTGDYERLSPYSGQLGDELAGLVRDYAKQQRYSFMGPIKVHLEKAEDLDTGLYRVRSRTLASSTSQDPSQGRQGGYGYPPVAAPPMPAGPPPGAPGGRPGGAPTTSGAPGTMRRWIEINGTRHQISRPTLVLGRSTEADVRIDDPGVSRRHCEIRTGTPPTIQDLGSTNGIVVDGQHTTRATLRDGSRIVVGSTTIIYRQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1E1</accession>
    <name>A0A0F4I1E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001836">
        <property type="protein sequence ID" value="KJY15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15845">
        <property type="protein sequence ID" value="KJY15845"/>
        <property type="gene ID" value="VR44_40750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8015" checksum="CF586B32C1337267" modified="2015-06-24" version="1" fragment="single">DALRAAAVARPVEEVRRMVTLLGEHPEEEAEADITLRAAAIGRPIEDVALLATILDPERPDADPVPVTRPAVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5R0</accession>
    <name>A0A0F4I5R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001700">
        <property type="protein sequence ID" value="KJY17014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952646.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001700.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17014">
        <property type="protein sequence ID" value="KJY17014"/>
        <property type="gene ID" value="VR44_40195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6523"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="34087" checksum="E89AFB80AD72E96B" modified="2015-06-24" version="1" fragment="single">HELPRVDLVLHGGEPLLAAPAELAAPVEAVRAALARRSPRTRVTASVQTNATLLTRARIAALAGAGIRIGVSLDGGLPAHNARRVDHAGRPGFGAAARGLRLLARHPAGYAGVLCVADIGQDPVETYESLLSFAPPAIGLLLPLANWSTPPPGRTGQAAGTPYADWLIAVFERWWHDGARRTRIRIFEEVIALLLGLPAATESLGLAPATTAVVETDGSIEQADSLKSAYEGAAATGMTLDTHSFDDLLDHPGFAARQLGREALAAGCRSCELVEVCGGGHYPHRYREGEGFQQPSVYCADLQALIRHIARAVHTAATTQRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6Y7</accession>
    <name>A0A0F4I6Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001683">
        <property type="protein sequence ID" value="KJY17223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952625.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001683.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17223">
        <property type="protein sequence ID" value="KJY17223"/>
        <property type="gene ID" value="VR44_40085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6357"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14577" checksum="5AA596910C40704F" modified="2015-06-24" version="1">MTTATLELRRFLTITGQRFKNGQSAPEMFSPAVDAAWHDMLGTPDYDVLCQETAGQPIRHVANNGHGPIAWVAAYEAAYGPLPDIWFTDAHGTVDEQAIARYRETGTVVAEWDCGPAGGDGDDLTPEQPPTHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8Q8</accession>
    <name>A0A0F4I8Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-deoxyerythronolide-B synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001642">
        <property type="protein sequence ID" value="KJY17848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17848">
        <property type="protein sequence ID" value="KJY17848"/>
        <property type="gene ID" value="VR44_39805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6143"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DE" evidence="2">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="325"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="500" mass="52518" checksum="12740EB39CE881AA" modified="2015-06-24" version="1" fragment="single">LHVHGAPVDWEAVLAGRGARRVDLPTYPFQHQPFWLVPAATRGTGPEAADPAEAAFWDTVENQDLAALAERLEVTGDSPLSSVLPALSQWRRRRRSRTVVDSWRYRISWQPLTGGRDTAELSGTWLLAVPGGGGEDAVVTAVSEALARHGAEVALLPVRTDETRTALAARLRPEPGATEPAGVLSLLALTDESHPDHPDLPAGLALTTLLVQALGDAGTTAPLWCATRGAVSTGRSDTPAGPRQAMVWGLGRSTALDHPDRWGGLVDLPATLDERAARRLVSLLAQGPGGEDQTAIRPSGIFVRRLTRALAPDTASPDRTWQPRGTVLITGGTGALGAHVARHLARNGADHLVLTGRRGPDAPGARELAAEIEELGAEVTLTACDLTDREQVAALLRDLPEDHHPLTAVIHAAGLPQFTPTDTLTPADLAAVVAAKATGAHHLDELLAGRDLDAFVLFSSVAAAWGSGSQAAYCAANAHLDALAEQRRARGLAATSVAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBM1</accession>
    <name>A0A0F4IBM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001553">
        <property type="protein sequence ID" value="KJY19407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952452.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001553.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19407">
        <property type="protein sequence ID" value="KJY19407"/>
        <property type="gene ID" value="VR44_39135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5590"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="14357" checksum="F6D2BE051B0FEDD6" modified="2015-06-24" version="1">MDDRTPASEWRWIDVVTPGTRLASVQRALAKLDVRDLGVGSTLAALARADLIEQDEVPRGRGRAVRAKMTRTGRAAVRAALKTAPGRRTGELADWAWEILVGLWQADGAQVRAGGPAVERALLDQRPAPRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDD4</accession>
    <name>A0A0F4IDD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001550">
        <property type="protein sequence ID" value="KJY19463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19463">
        <property type="protein sequence ID" value="KJY19463"/>
        <property type="gene ID" value="VR44_39095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="25850" checksum="96E8AA598AC66109" modified="2015-06-24" version="1" fragment="single">LLPGPVPRWWAGAVGRALGWGPEVEVYDGLAGRGPGLSEAVLARPALARRMRECGLPLVPWGRTEPYARLAGLPWRPDALRYESKSRAHALFARILAGGGHPAVTLPAQWRAGSRRAAVRWVAARARAGESTVLKSEHGVGGSGTTLVTPERVRAAGGARALVRGLPRGPLLVEEYVHGPAEGEAPRDLTYDGFVDGEGRPHRVGAALMDVADGGYRGATVGPGVVPAQLEGPLLAFGAAVGRELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE21</accession>
    <name>A0A0F4IE21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001514">
        <property type="protein sequence ID" value="KJY20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952389.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001514.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20237">
        <property type="protein sequence ID" value="KJY20237"/>
        <property type="gene ID" value="VR44_38790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5471"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19925" checksum="653F6BD04CDFDD9B" modified="2015-06-24" version="1">MHDATFAELLAATERTAVHLEMRDSYAVGDEADDFSTFLRTGIPNLDPTRSFWPQWMPLVQEAVGRGVVMRRARIVSEPVTDYIRYEHAITPLNLEAGEEVRWLPRREASTIALPGNDFWLLDDTVVQFHHFTGTGDWAKDGRERTTDPAAAAAALCRTAFEKVWERAVPHAKYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEG8</accession>
    <name>A0A0F4IEG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001521">
        <property type="protein sequence ID" value="KJY20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20069">
        <property type="protein sequence ID" value="KJY20069"/>
        <property type="gene ID" value="VR44_38850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5485"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15515" checksum="534C5096FC938A66" modified="2015-06-24" version="1" fragment="single">REFLDEHLAGRTVDRVLPLAVSVLKTYDPPLTALEGQPTGPVARHGKFLDLRIGGLHLVTHLARAGWLRWQDALPAQPPRPGKGPLALRLVLDDGAGFDLTEAGTQKRLAVYVVHDPQEVPGIARLGPDPLAAGFDRDAFAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IG43</accession>
    <name>A0A0F4IG43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxylate carboligase</fullName>
            <ecNumber evidence="3">4.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.47" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001471">
        <property type="protein sequence ID" value="KJY21000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3728"/>
    <dbReference type="EnsemblBacteria" id="KJY21000">
        <property type="protein sequence ID" value="KJY21000"/>
        <property type="gene ID" value="VR44_38425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22323" checksum="E5BF1E6855A24D86" modified="2015-06-24" version="1" fragment="single">MTAAAAAVEILKLEGVEQAFGVPGAAINPFYRELKNVGGIAHTLARHVEGASHMAEGYTRAKAGNIGVCIGTSGPAGTDMITGLYSAIADSIPILCITGQAPVSKLHKEDFQAVDIATIAKPVTKAATTVLEAAQVPGVFQQAFHLMRSGRPGPVLIDLPIDVQLTEIEFDPETYTPLPVYKPQASRAQAEKALGFLLEAERPLIVAGGGIINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IL16</accession>
    <name>A0A0F4IL16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001460">
        <property type="protein sequence ID" value="KJY21316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21316">
        <property type="protein sequence ID" value="KJY21316"/>
        <property type="gene ID" value="VR44_38305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Docking" evidence="2">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13567" checksum="59DC184774DE1D3A" modified="2015-06-24" version="1" fragment="single">MSNTPQTANEAKLLQYLKRVTSDLDRANDRLREVEATAGEPIAIVGMSCRFPGGVESPEDFWELLASGADGITPFPADRGWDLDRLVDEDPERTGTSYVREGGFLRGAAEFDAAFFGISPREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INV9</accession>
    <name>A0A0F4INV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001382">
        <property type="protein sequence ID" value="KJY23712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23712">
        <property type="protein sequence ID" value="KJY23712"/>
        <property type="gene ID" value="VR44_37510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10132" checksum="7071AB794954490F" modified="2015-06-24" version="1" fragment="single">MTSRLRGLPAGFGRLWTAQTVSSLGDGVTHAALPLIALTLTRDPLALAVVTAAGTLPWLLFGVLGGALVDRWDRRRTMWVTDALRAALLAIPVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPB4</accession>
    <name>A0A0F4IPB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001340">
        <property type="protein sequence ID" value="KJY23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952052.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001340.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7422"/>
    <dbReference type="EnsemblBacteria" id="KJY23880">
        <property type="protein sequence ID" value="KJY23880"/>
        <property type="gene ID" value="VR44_36985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4781"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="20030" checksum="361F6194088E6406" modified="2015-06-24" version="1">MAVSLSKGGNISLSKEAPGLSAVTVGLGWDVRTTTGVDFDLDASAIAVDATGKVVSDGHFVFFNNKSTPDQTIVHTGDNRTGEGSGDDESIKVNLAGLPASVDKIVFPVSIYDADSRSQNFGQVRNAYIRVVNQAGGAEIARYDLSEDAATETAMVFGELYRNGAEWKFRAVGQGYASGLTGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPN3</accession>
    <name>A0A0F4IPN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001316">
        <property type="protein sequence ID" value="KJY23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951991.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001316.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23985">
        <property type="protein sequence ID" value="KJY23985"/>
        <property type="gene ID" value="VR44_36675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4644"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="42779" checksum="0FFE2792BBE685C7" modified="2015-06-24" version="1">MTEGVRGEGVGSGGGVERVLRAAAPHEVFEEVRGVLIRDHGAAGAELLMADYAAARLRPVTAEPFTADSVSAYNGGEGRAFGAQEAHVVAGEDETTVHLPVTVRGDRLGVLSVRFAAGVPVGGLLGPLQDVADALAHEILVADRDTDFFLQARRTRRLTLAAEMQWQLLPGRSCSRPEYDLGAQLEPAYAIFGDSFDWSASADHLTLTVNNGMGEGVEAALLTSLAVSALRNARRAGLGLADQAALADQALYGHYQGHRHLSMLLLRFDLDTGEVEAVDAGSPRLWRLRGGTVEPVALEAQLPLGMFEDTVYTCQRFTVLPGDRLLLLSDGVYDVLSPAGEPYGARALTRAVMNTRLLPPAQVPKALLEELPGYRGGVDAADDAMVVCLDWHGRPGAGTDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPT7</accession>
    <name>A0A0F4IPT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001306">
        <property type="protein sequence ID" value="KJY24040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951961.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001306.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24040">
        <property type="protein sequence ID" value="KJY24040"/>
        <property type="gene ID" value="VR44_36505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4604"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="15224" checksum="F38926440AC1C495" modified="2015-06-24" version="1">MTLTMTVGKAGAAGTAGATNTDGGDGGAGGDSSTYMEDQLVARAGGGGGGFAGHRSGTFGSGTGGAAGQAQPHGDGACLNGRTMSSAPAAAGENGADGSRNNQGKGGWGGRTVTTFGNPNGNGGSGGIGAGIVGGGDGNRGDHTDAGTGSEGMDGLITLTYTPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPV8</accession>
    <name>A0A0F4IPV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001381">
        <property type="protein sequence ID" value="KJY23719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23719">
        <property type="protein sequence ID" value="KJY23719"/>
        <property type="gene ID" value="VR44_37505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4920"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="498" mass="52495" checksum="884CCBC273E3AB4C" modified="2015-06-24" version="1" fragment="single">AGRADLARRATRAVLARDASPAQRVRARLAVIDAAGQALAALDETFAFACAEADAADDPSLLAAVQLRIAWKHNLSDGDPVRSRDAAAEAGALAKAGGDQVAEAMALTVRARMGRILADPDAEDILAEALALPAPEVPLGMRNAPQYLAVRHALFDDRLADARSRLLVLLPAVQRTGSAEDVFEVLRSLTEVELRRGACALGAAHARRALELTIEAGLSPGPAWYVAATAEAAGGSFARAAAYARRGIRASEEEHDQVFLSRGLYALGTVELATGEAARAVATLRRVAELEEAQQVVDPSILRWHGELAEALVAADDPAGAVALLDAVTPVARSLERTSVLAALDRARGLALSAQGEPESAVALLRATAQRFDALGLPLEHGRTLLALARVERRRRRRAPARAALRDAAELFERAGAEPWLCLARENAPETGVPHPGAAALTDAEARLALLVGGGASNQEAAAKLFLSVKTVEARLTRIYQKLDVRSRAQLATALRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQK9</accession>
    <name>A0A0F4IQK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001326">
        <property type="protein sequence ID" value="KJY23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952018.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001326.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23939">
        <property type="protein sequence ID" value="KJY23939"/>
        <property type="gene ID" value="VR44_36795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4671"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22646" checksum="0D1CEDD8728F5B2A" modified="2015-06-24" version="1">MPKYVDPEARRRDVVDALFRVVVRDGLQRASLRAVADEAGLNIGSLRHYFASQRELMDFAMQSMLDRLGARLVRRVEEAGDLGRHPGPERLRLAVELLAELLPLDEVRRAEVAVFLDFNTAARTSPEFAGLARRTAVGARELVRRLLGRLEATGTLRPGLDLDTETERLTALLDGLGMTAVLHPDLLGAEACLAVLRGHLGDLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQM8</accession>
    <name>A0A0F4IQM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001251">
        <property type="protein sequence ID" value="KJY24307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001251.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24307">
        <property type="protein sequence ID" value="KJY24307"/>
        <property type="gene ID" value="VR44_35755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4305"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23527" checksum="87133EF100139BB1" modified="2015-06-24" version="1">MTETGAPIRVVVADDQTVVREGLVLLLGLLPGTEVVAAAADGAEAVRLVAEHAPDVVLMDLRMPRTDGVEATRLITRDHPGTGVVVLTTYSDDTSVMDALRAGARGYLTKDADAQEIARALAAVREGATSLGRAAQERLVAAAVAGAEPPARPQDAALPDGLTAREGEVLALIAGGHSNSEIARRLTIGESTVKTHINNLFAKTGVRDRAQAVRYAYRHGLATPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQX2</accession>
    <name>A0A0F4IQX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001233">
        <property type="protein sequence ID" value="KJY24402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24402">
        <property type="protein sequence ID" value="KJY24402"/>
        <property type="gene ID" value="VR44_35485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15392" checksum="C763862A52F26CD2" modified="2015-06-24" version="1" fragment="single">VLDTPEEMPPALAHRLAPWTVSTAAWLCGTGARLVVAARPEYWERAGTFYPPELLHTPARPARRLPPALPVGDLTPAEADTARARLGIPADALREADARHPLTLSLLAGIRAAGVREGRPTRDEVFTAHLDLLCLRTALRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRC7</accession>
    <name>A0A0F4IRC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001309">
        <property type="protein sequence ID" value="KJY24023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24023">
        <property type="protein sequence ID" value="KJY24023"/>
        <property type="gene ID" value="VR44_36545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4614"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="29839" checksum="90BBC6A52258464C" modified="2015-06-24" version="1">MRKPVPVPWICPPQGGRPPKHGGEFVFGNPGTWGEVTAVTVTNTNTNRYGAATAQAWDRLHPRLTRRAAWLDHEEPLPIIEGTVIRLTVENLPSGGVNKPVWLWWSGTGATKQDVDRCWQSFLRRFDLEHTFRLLKQTLGWTRPRLRNSGAADRWTWLVLAAHAQLRLARPLARDLRRPWERPAEPNRLTPARVRRGFRNLHAKTGTPALAPKPTRPGPGRPPGSSNRRPASRYEVGRVLVTGESYTRPAHHKVGTKPHRTGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRL9</accession>
    <name>A0A0F4IRL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001250">
        <property type="protein sequence ID" value="KJY24314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951811.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24314">
        <property type="protein sequence ID" value="KJY24314"/>
        <property type="gene ID" value="VR44_35715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="20956" checksum="65B6E37A80804997" modified="2015-06-24" version="1">MSTITLTTWSLEMTSPADLVPAAEPGPEITISRAEVPSPEFSRFLYASVGGDIHWTDRLSLTRAEWLEQLDRPGVETWVAYDRGTPAGYIELDPQPDGVVEIMYFGLLPDFRGRRIGGHLLTLGTARAWDLAERWPGLEPTRRVWVHTCSQDGPTAMDNYQRRGFKVFKTETEEKPDTPTPGPWPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRW7</accession>
    <name>A0A0F4IRW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001175">
        <property type="protein sequence ID" value="KJY24737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951578.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001175.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4277"/>
    <dbReference type="EnsemblBacteria" id="KJY24737">
        <property type="protein sequence ID" value="KJY24737"/>
        <property type="gene ID" value="VR44_34450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3870"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="15187" checksum="4DEF99144067808A" modified="2015-06-24" version="1">MAYEVQKTDEQWQAELTPSEYQVLRLAGTEPAFRGEYTDTKTEGVYSCRGCGAELFRSTEKFESHCGWPSFYDPKDSEAVELKADTSHGMVRTEVLCAKCGSHLGHVFEGEGYPTPTDQRYCINSISLRLTPTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRY5</accession>
    <name>A0A0F4IRY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001169">
        <property type="protein sequence ID" value="KJY24785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951554.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24785">
        <property type="protein sequence ID" value="KJY24785"/>
        <property type="gene ID" value="VR44_34310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3839"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16913" checksum="F21DB97754C40984" modified="2015-06-24" version="1" fragment="single">WVADLAREHGSFEVTPVDLAEVALPFLDEPEFPSSGNYTHQHTRDWSALIEPAEAFVFVLPMYNGGFTAPFKNAVDFLYAEWQGKPVGIVSYSAGGSGGAPAAEMLLPVLTQVGMVPAARSAAVPGVLGLLGADGFTAPEGLAAEVSGVLDDIAALVKEPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT88</accession>
    <name>A0A0F4IT88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001105">
        <property type="protein sequence ID" value="KJY25225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951324.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25225">
        <property type="protein sequence ID" value="KJY25225"/>
        <property type="gene ID" value="VR44_33070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3486"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19263" checksum="D3AF8CF67A91C672" modified="2015-06-24" version="1">MTSPRSTYGGGYYSAPSFPDTPIYDSLVAERGTPQIAPIRVPAAYDTPGASYSSGGYLPALASSMPALPPAPAQPAPSPAYGYGYQQQPAAPAPMPVPLQHAPAPYVPQQQLPQRGGFVPQPQPQQPRPLAAGTGYEAMRPAAPRPMTAPMQMVAPVPTAVPAAAAVPSYQDPYGGQGQYQNRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITB2</accession>
    <name>A0A0F4ITB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">VR44_33005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="JZWV01001102">
        <property type="protein sequence ID" value="KJY25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951312.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001102.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene102"/>
    <dbReference type="EnsemblBacteria" id="KJY25242">
        <property type="protein sequence ID" value="KJY25242"/>
        <property type="gene ID" value="VR44_33005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3473"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28053" checksum="DF81C26F6169E802" modified="2015-06-24" version="1">MTQTVAVLGTGKIGEALLSGMIRGGRPPAKLLVTARRPERAAELHSRYGVEAVSNAEAAKRADTLILTVKPQDMGKLLEELAPHVPADRLVISGAAGIPTAFFEERLAPGTPVVRVMTNTPALVDEAMSVISAGSHATAEHLAHTEEIFGGVGKTLRVPESQQDAATALSGSGPAYFYFLVEAMTDAGILLGLPRAQAHDLIVQAAIGAAVMLRDSGEHPVKLREAVTSPAGTTINAIVELEKHGVRAALIAALEAARDRSRELATGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITF8</accession>
    <name>A0A0F4ITF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001322">
        <property type="protein sequence ID" value="KJY23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952008.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001322.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23961">
        <property type="protein sequence ID" value="KJY23961"/>
        <property type="gene ID" value="VR44_36735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4656"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="30576" checksum="4D337757275C568D" modified="2015-06-24" version="1">MSRRARVSPAEAGLPDGGARRRTPGLRREEVAVLAGVGVSWYQWLEQGRDITVSGQVLDAVSRVLKLTSAERRHLYVLAGLNPPALEVAPGDRDMCQGLQRLIDAWMPFPAHIMDTYWNTVMYNDAAALVLGMRPEIVQNCLIAFFTDPVYMARSPHWEEIAVEVVAQFRAACSEHPEDEGFQAVLEQARELSPRFTELWERQEIRPGGQLRKEMEHPVVGTLHVETTQLRVPARPDLAIVLHTPLPGTETAEKLEWLTSPEGRRGLMYPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU37</accession>
    <name>A0A0F4IU37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951174.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25525">
        <property type="protein sequence ID" value="KJY25525"/>
        <property type="gene ID" value="VR44_32240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3169"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="31405" checksum="FA8F646F7E7C73D0" modified="2015-06-24" version="1">MAWLALDEGYEVSLVEGRVAVRRPAGRQLKTVPKALRDHPEVDRLRRLAEWLDRHEAACAAQVDGWMVSSLPVPTALLARVWRDEAWQAALRDLAVVGDGDPDEVGFLRDATDAGELKVVNLDGETVRLSPRTVTLPHPVLLPDLDDVREFAAELDITQRVEQIHRATWTRPEDVKESATEVRDYAGGKFPSRFSLAARATGLGYRVSGGYATCRVRDGGRAVEAAVWIGEPYWEDESETGALSWHDEEGRAVRLGEVGPVAWSEGMRMAAALYAGRKIEEGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV87</accession>
    <name>A0A0F4IV87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001010">
        <property type="protein sequence ID" value="KJY25925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950984.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001010.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000066_gene6666"/>
    <dbReference type="EnsemblBacteria" id="KJY25925">
        <property type="protein sequence ID" value="KJY25925"/>
        <property type="gene ID" value="VR44_31255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2738"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="373" mass="41843" checksum="C0D7EA12E90CEFB7" modified="2015-06-24" version="1">MEFGLFVQGYVPEARSKVDPEAEHKALLEETQYVIQADKSGFKYAWASEHHFLEEYSHLSANEVFLGYLAAATERIHLGSGIFNPLAPVNHPVKVAEKVTMLDHLSKGRFEFGTGRGAGSHEILGFLPGITDMNHTKEIWEETIAEFPKMFLQEEYEGFQGKHWSLPPRKIFPKPYGKAHPAMWYAAGSPSSYAMAAKKGLGVLGFSVQKVSDMEWVLEQYKTAIQEAKAVGAFVNDNVMVTSTAICAETHEKAVEIAVNANMNRFQSLVFRYHDTFPRPEAIPEWPETLPEYNAEIIELLIAEELLICGDPAEVRAQCKRWEEAGADQLSFGLPTGVSYEDTMTTIKLIGEHVIPHIDTDPVHRTTRFRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVC3</accession>
    <name>A0A0F4IVC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_31160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001005">
        <property type="protein sequence ID" value="KJY25952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000037_gene7500"/>
    <dbReference type="EnsemblBacteria" id="KJY25952">
        <property type="protein sequence ID" value="KJY25952"/>
        <property type="gene ID" value="VR44_31160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2720"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="53"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="20443" checksum="DCC1A3104C491E9B" modified="2015-06-24" version="1" fragment="single">GRAVPLVADAVSFALSALLVRSLPAVPRPVPQARESLLRQARAGASYVFRDRLLLGLALRPAVGNVAFLAVEIVLALFAYDRLGIGSFGFGLLLTAEATGGLLGAALASFLGRRLGTGTALTCTAAVEGLAVMGLAAAPNPYVAGLALAVCGAGMGATMVLAPSLRQSIVPPQLVGRIASTSRMLAMCAAPFGAFLGGWLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVL1</accession>
    <name>A0A0F4IVL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001176">
        <property type="protein sequence ID" value="KJY24731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951583.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001176.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24731">
        <property type="protein sequence ID" value="KJY24731"/>
        <property type="gene ID" value="VR44_34480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3877"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="14500" checksum="E832303C3213FD49" modified="2015-06-24" version="1">MATTRHAHTVWEGNLLEGKGVVSLDSSGIGKYDVSWPSRAEAANGKTSPEELIAAAHSSCFSMALSHGLAGKGTPPTRLETKADVTFQPGEGITGIHLTVEGEVPGIDNDAFVAAAEDAKKNCPVSQALTGTTITLSAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVN5</accession>
    <name>A0A0F4IVN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000988">
        <property type="protein sequence ID" value="KJY26067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26067">
        <property type="protein sequence ID" value="KJY26067"/>
        <property type="gene ID" value="VR44_30950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2696"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7400" checksum="36A111B48CB2584D" modified="2015-06-24" version="1" fragment="single">TEADTGDAERAVTLLAAANSLRMSTGRESTPMERPALLYACAEKAGVAFAPEVALHYAPGTAAAPRLADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW19</accession>
    <name>A0A0F4IW19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001153">
        <property type="protein sequence ID" value="KJY24886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951510.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001153.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24886">
        <property type="protein sequence ID" value="KJY24886"/>
        <property type="gene ID" value="VR44_34070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3741"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="37"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21979" checksum="4A264A5BFC60EB3C" modified="2015-06-24" version="1">MALFSRRSRTATPAAPTQQGAVATLAVDPALAALTGDYVIDAGHSSIGFTVRHAMVTNVRGSFAEHEGTLHLDGGDPSRSTASIDVKIASVSTGIADRDAHLRSGDFFDAEAYPLMTFRSTSAAHVGGDTYRVSGDLTIKDVTRPLSIDLEFAGSATDVYGNERVGFEGSAEILRSDWGLTWNAALEAGGVMVSDKVKLTFDISAIKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWA4</accession>
    <name>A0A0F4IWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_31735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001030">
        <property type="protein sequence ID" value="KJY25743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951080.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25743">
        <property type="protein sequence ID" value="KJY25743"/>
        <property type="gene ID" value="VR44_31735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3057"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="220"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="407"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="562" mass="58701" checksum="27351C3C1E982A19" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWK7</accession>
    <name>A0A0F4IWK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_33585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001127">
        <property type="protein sequence ID" value="KJY25056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030713714.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001127.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5673"/>
    <dbReference type="EnsemblBacteria" id="KJY25056">
        <property type="protein sequence ID" value="KJY25056"/>
        <property type="gene ID" value="VR44_33585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3599"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="12106" checksum="1593F6DA4473B508" modified="2015-06-24" version="1">MTYVIAEPCVDVKDKACIEECPVDCIYEGQRSLYIHPDECVDCGACEPVCPVEAIFYEDDTPEEWKDYYKANVEFFDELGSPGGASKLGLIERDHPFIAALPAGINGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYT6</accession>
    <name>A0A0F4IYT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oleate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001019">
        <property type="protein sequence ID" value="KJY25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951027.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25836">
        <property type="protein sequence ID" value="KJY25836"/>
        <property type="gene ID" value="VR44_31465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2786"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="521" mass="58210" checksum="73F8FD7DD66ADCEE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ91</accession>
    <name>A0A0F4IZ91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000882">
        <property type="protein sequence ID" value="KJY26954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950534.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000882.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26954">
        <property type="protein sequence ID" value="KJY26954"/>
        <property type="gene ID" value="VR44_28765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2085"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="469" mass="48526" checksum="ADE3E54492A52A67" modified="2015-06-24" version="1">MGFGLRWTLHGDGRTPAPGAVVRPDERLSWPRTAGLGAQHVVAMFGASFVSPVLMGLDPNLAIMMSGIATAVFLLATRGRVPSYLGCSLSFVGVAAAIRAGGGDSAVVTGAVFVVGAALFLAGLAVQRFGARIIHAAMPPVVTGAVVMLIGFNLAPVTAATYWPQDQWTALLTMLFTGLAVVCLRGFWSRIAIFLGLVFGYGISWVFDLVFGKIHSPAGGTEAVDHWRLDLSGVGEADWIGLPNLHGPSFQWSAILIALPVVIALIAENAGHIKAVGEMTGDPLDDKLGTAIAADGAASMLSTAVGGPPNTTYSENIGVMAATRVYSTAAYWAAAGFALLFGLCPKFGAVVAAIPGGVLGGITVILYGMIGLLGAQIWLNGRVDLRNPLNLVPAAAGIIIGVGGVKLHFSDSFELGGIALGTIVVITGYHALRYFAPEHLKRQEPLLDSGTSDYDSAEEPAGEPGDKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J003</accession>
    <name>A0A0F4J003_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Cas2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000962">
        <property type="protein sequence ID" value="KJY26256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950856.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000962.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26256">
        <property type="protein sequence ID" value="KJY26256"/>
        <property type="gene ID" value="VR44_30525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010152">
        <property type="entry name" value="CRISPR-assoc_prot_Cas2_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09707">
        <property type="entry name" value="Cas_Cas2CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01873">
        <property type="entry name" value="cas_CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12978" checksum="612A73667B6E3695" modified="2015-06-24" version="1">MTVIVLTQCPVGLRGFLTRWLLEISPGVFIGGPSARIRAALWEEVKQYAGQGRALLAYNTDNEQGFTFETHDHKWHPIDREGVTLIHRPNERVSQVPPVTQGWSKAAKRRRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J072</accession>
    <name>A0A0F4J072_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950475.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000868.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1154"/>
    <dbReference type="EnsemblBacteria" id="KJY27123">
        <property type="protein sequence ID" value="KJY27123"/>
        <property type="gene ID" value="VR44_28440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2013"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="26449" checksum="24599394B77E812B" modified="2015-06-24" version="1">MAELVYPPVIGAAHTLFRALDIRIDMKGTENIPRKGGAVLVSNHIGYLDFIFAGLTARPQKRLVRFMAKESVFRHKVSGPLMRAMKHIPVDRQQGESAYRHALESLRSGEIIGVFPEATISQSFTLKSFKSGAARMAQEAGVPLIPVALWGTQRLWTKGRPKNLKRSHIPVTMRVGEPIEAPKDQYAGAITRRLRERVQELLEAAQAAYPAKPQGTEDSWWLPAHLGGTAPTAAQVKEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0S9</accession>
    <name>A0A0F4J0S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000830">
        <property type="protein sequence ID" value="KJY27474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950295.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000830.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5365"/>
    <dbReference type="EnsemblBacteria" id="KJY27474">
        <property type="protein sequence ID" value="KJY27474"/>
        <property type="gene ID" value="VR44_27420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1651"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26624" checksum="79DAE9324E94C9DB" modified="2015-06-24" version="1">MKYGERTSEAPQGELATGERSTRNRVARSILDHGPSTVADLAQRLGLTQAAVRRHLDTLVADDVVAPREQRVYGARTRGRPAKVFALTDCGRDAFDQSYDKLAVDALRWIAQSVGGGEKGEAAVAAFARARMATQAEAYREAVEAAAPADRTEALAKALTADGYAATAKSAPGPHSGEQLCQHHCPVAHVAEQYPQLCEAETEVFSRLLGTHVQRLATIAHGDGVCTTFIPRSAAQHDTPASASTAGRNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1A6</accession>
    <name>A0A0F4J1A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oleoyl-ACP hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000768">
        <property type="protein sequence ID" value="KJY28047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950067.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000768.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28047">
        <property type="protein sequence ID" value="KJY28047"/>
        <property type="gene ID" value="VR44_26210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1398"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="33"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="28100" checksum="78FBCCE4DBE78FEB" modified="2015-06-24" version="1">MTTLRATTAANPWIRRFHPPARPDTAPVLVVLPHAGGSASYYFPLSRDLAAHAEVLTVQYPGRQERLSEPSPDTIAGLVDGVEDALAPWRERPLVLFGHSMGAVLAYELTRRLEASGAAPRGLILSGRRSPLVPRHDDLHTLDDDALLAHVRALSGTDTTLLADPELQAMILPALRSDYHAVGTYRHEPGPPLRTPVSVLCGESDPRAAVPEAMAWRELTEGAFTFRGFPGGHFYLAERHEAVTSAIADDLKAFMTGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J250</accession>
    <name>A0A0F4J250_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949948.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28335">
        <property type="protein sequence ID" value="KJY28335"/>
        <property type="gene ID" value="VR44_25550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13218" checksum="FDA86A5D636FD2B3" modified="2015-06-24" version="1" fragment="single">MTSSPHSSSDSSDGRDSGDGSHLTRIAAPEGVSPGTGYSHVVWGTGRFVAVSGQCALDEKGEVVGEGDPAAQARRVFENLRRCLAAAGAGFEDVVKLTYFVTDVAHLPAVRAARDEVIAPHLLPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2Y3</accession>
    <name>A0A0F4J2Y3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_24815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949803.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000708.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28702">
        <property type="protein sequence ID" value="KJY28702"/>
        <property type="gene ID" value="VR44_24815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.962"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470536" description="SSI domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="4">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14546" checksum="3847163A339F9D10" modified="2015-06-24" version="1">MLRLAAFAVTSALAAAAAGPLPPLPLGRLLASPDRLTIDISKAGSLNGRYRLDCRPVGGDHPKAEEACSRLDALAKQGKDPFAAAPKAAMCTFQSGGPATAHVTGTWHGEKVDSWFRRENGCDIARWDNLEPVLPSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3K1</accession>
    <name>A0A0F4J3K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000829">
        <property type="protein sequence ID" value="KJY27486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27486">
        <property type="protein sequence ID" value="KJY27486"/>
        <property type="gene ID" value="VR44_27390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1645"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12193" checksum="F2A5E41E085A490E" modified="2015-06-24" version="1">MADTADTAQTAEAADKKHSRTAAKLARQIGAFAKEHGGAEGQLAHIGQAGTRIVLVGTDGGWGDLVAPTYAVAQLAAEKAGLTLHEDFDGELAARVRTGPYEWTRMAGIQVGGPANPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3X6</accession>
    <name>A0A0F4J3X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_23865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949630.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000681.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29047">
        <property type="protein sequence ID" value="KJY29047"/>
        <property type="gene ID" value="VR44_23865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.746"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470711" evidence="4">
        <location>
            <begin position="34"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="603"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="638"/>
            <end position="645"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="903" mass="94258" checksum="F9058E578D641E6E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J419</accession>
    <name>A0A0F4J419_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000807">
        <property type="protein sequence ID" value="KJY27686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950221.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000807.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27686">
        <property type="protein sequence ID" value="KJY27686"/>
        <property type="gene ID" value="VR44_27025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1567"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13386" checksum="EE72C79D5FAF063D" modified="2015-06-24" version="1">MSGIRRISSGGAYEDVIGYSRAVALPNGLVLVSGCTAAGVDGPYDQTMTAFGVAFKALAEAGLGPEHVVRTRMYLTHARDVDEVGRAHKSLFDAVRPAASMIIVNGFVDPTMVVEVEVEAFKEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J559</accession>
    <name>A0A0F4J559_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000689">
        <property type="protein sequence ID" value="KJY28954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28954">
        <property type="protein sequence ID" value="KJY28954"/>
        <property type="gene ID" value="VR44_24090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="11917" checksum="71E89D079AE1A512" modified="2015-06-24" version="1" fragment="single">MTATTAAPAPVPVPSLGRRVLALMGPMVVASVMGQAIAQTDLWVISTLGEQAVAAAAVPQRLLLLDSITAMAMGPVVGLSVAGAVSAHARRRAVQGGLVGATAAGLLIAAAGLAVLPYLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5B9</accession>
    <name>A0A0F4J5B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000762">
        <property type="protein sequence ID" value="KJY28116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950032.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000762.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28116">
        <property type="protein sequence ID" value="KJY28116"/>
        <property type="gene ID" value="VR44_26025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1358"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="36495" checksum="8055E23BA899A2BE" modified="2015-06-24" version="1">MIDLLVAGGGPAGLATAIHGALAGLEVVVLEPRPTPIDKACGEGLMPGAVRRFEELGVAVTGRPFHGIGYVDGVTGLRAEGLFRRGPGRGCRRTDLQAALADRAAGLGVRVLARRVGEVRQDGRRVWAAGLTARYLVAADGLHSPVRRGLGLAVPAAAGRAAARYGLRRHYAVEPWSDLVEVHWARGAEAYVTPLAADRIGVAVLTSEQAPFDLQLARFPLLAARLPPPAPGGGAGVRGAGPLRQRARTRVAGRVLFVGDAAGYVDALTGEGLTLAVSAAGELVRCVRAGRPQEYERAWRELSRGYRVLTSSLLWARRRTPLAGRIVPLAARMPRVFTGAVNLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J657</accession>
    <name>A0A0F4J657_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000625">
        <property type="protein sequence ID" value="KJY29675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29675">
        <property type="protein sequence ID" value="KJY29675"/>
        <property type="gene ID" value="VR44_22325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14116" checksum="C240B19E89C74E00" modified="2015-06-24" version="1" fragment="single">MSDWDGFGGERDARGRRDDGYGRGSGQAQPEGPQRMRHVQRQPQAPRPPRPQPRPAQGPGRTPVPPQAPPPGARPGPGYGVPPQQRQDPDAAYDSGYNTGQVYGRPSGPGRPSGPGGPGRPGGPGGPGGTGRPAGPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J698</accession>
    <name>A0A0F4J698_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-ketosteroid-delta-1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949918.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000734.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28421">
        <property type="protein sequence ID" value="KJY28421"/>
        <property type="gene ID" value="VR44_25410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1178"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="563" mass="59054" checksum="966C47A546805EB8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6U8</accession>
    <name>A0A0F4J6U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000640">
        <property type="protein sequence ID" value="KJY29483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29483">
        <property type="protein sequence ID" value="KJY29483"/>
        <property type="gene ID" value="VR44_22850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.504"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="630" mass="66940" checksum="31764EAB31DF3D5C" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J764</accession>
    <name>A0A0F4J764_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_20905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949082.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30227">
        <property type="protein sequence ID" value="KJY30227"/>
        <property type="gene ID" value="VR44_20905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8911"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="33462" checksum="422E6DA376231F7F" modified="2015-06-24" version="1">MSSSTPPEPEPGVIAGERRHLTNLAYRLLGSLTEAEDAVQESYARWYAMPRPQRAAIDSPGAWLTTVISRICLDVLGSARVRRERYVGEWVPEPLPDRTEWPGGPRSATDPADRVTIDDSVDMAFLVVLESMTPAERVAFILHDVFRYPFPEIARIVDRTPAACRQLAASARRRVAATAPPASPSPQQASVLREFKEAWQSSDIRTLVALLDPGATMVADGGGLVSAVRRTIEGGRDIAGYLMHIAGLSPGLTLLQRTVNGRPGLVAQRDGVTVTVAAFHLTEGRITRIWAVRNPEKLRPWTAPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7F6</accession>
    <name>A0A0F4J7F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000624">
        <property type="protein sequence ID" value="KJY29683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949342.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000624.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29683">
        <property type="protein sequence ID" value="KJY29683"/>
        <property type="gene ID" value="VR44_22285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="32210" checksum="6EF831A2A0196172" modified="2015-06-24" version="1" fragment="single">LVWTLRQSPYHDIDTPDTEVDTDIPRLRAGGVGAQFWTLLVPPGPPRADSCAQAVCETLEQIDAARALMRRYSESLCLALTADDMADARNRGRIASFLGPVPGSTLTGSLGALRAFHALGVRLLAPAGAPWADEGLTAFGHEVVKEANRLAILLDLAGCPPAAACQLVAASKAPVIISNTGAASLNPHPGNATDEVLLALRAGGGLAMVTFDTDRTGDSLHAVADHVEHVRALAGPEGVGLGAAFGSEHGSPRPAGLTDPSGYPRLIAELLERGWSETEVALLSWGNAQRVLREAEFTARAAQYKGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J817</accession>
    <name>A0A0F4J817_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813786.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene197"/>
    <dbReference type="EnsemblBacteria" id="KJY29086">
        <property type="protein sequence ID" value="KJY29086"/>
        <property type="gene ID" value="VR44_23750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.723"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="25154" checksum="E5EE01A2D1F77553" modified="2015-06-24" version="1">MRDAYHEELDSIGESLVEMARLVGSAIGRATTSMLDADLKLAESVIAADQKVDDLQHDLEARAIALLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLARLRFPDRAVPRDLHATILEMGQLAQRLMAKAAEVIITKDVDLALQLEQDDDEMDQLHRTLFQHLMDDRWKHGIETAVDVTLLGRYYERFADHAVSVAKRVVYLVTGEHADELQQPTQVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8X8</accession>
    <name>A0A0F4J8X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000550.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30640">
        <property type="protein sequence ID" value="KJY30640"/>
        <property type="gene ID" value="VR44_19945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8609"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11815" checksum="58105F3AFDC8EE6C" modified="2015-06-24" version="1">MSIVKINALTVPDEQREVLEQRFASRAGAVESSDGFEWFELLRPIEGTDQYLVYTRWRSEEDFQAWMEGPMKAAHQGGGDRPKPAASGSQVWSFEVVQQAAPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9C1</accession>
    <name>A0A0F4J9C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000634">
        <property type="protein sequence ID" value="KJY29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000634.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29556">
        <property type="protein sequence ID" value="KJY29556"/>
        <property type="gene ID" value="VR44_22635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.420"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14290" checksum="007F638975A9AF1D" modified="2015-06-24" version="1">MRIHLTHVFVDDQDKALRFYTDVLGFVKKHDVPLGGTDRWLTVVSPEDPDGTELLLEPSGHRAVGPYKTALVEDGIPAASFAVDDVHAEFARLRGLGVRFAQEPVETGPVTTAVLDDTCGNLIQLVRAAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA11</accession>
    <name>A0A0F4JA11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_19975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948910.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4931"/>
    <dbReference type="EnsemblBacteria" id="KJY30644">
        <property type="protein sequence ID" value="KJY30644"/>
        <property type="gene ID" value="VR44_19975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8616"/>
    <dbReference type="eggNOG" id="COG2119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20153" checksum="DDF322D9C0A2A3AD" modified="2015-06-24" version="1">MFSFTVLAIAFGVVFLAELPDKTALAGLMLGTRYRASYVFAGVAAAFAVHVALAIAAGSVLTLLPHRLVQGVVGLLFLAGAAMLLFKKGDEEEEVKAPADQSFWKVSGAGFMLILVAEFGDLTQIMTANLAARYDNPLSVGLGAVLALWAVAGIGILGGRTLMKYVPLRLITKVAACVMLALAGFSLYEAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAF2</accession>
    <name>A0A0F4JAF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948603.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31352">
        <property type="protein sequence ID" value="KJY31352"/>
        <property type="gene ID" value="VR44_18320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="17196" checksum="304A74DA85D6DBAD" modified="2015-06-24" version="1">MSETHRSRLSNPVKTLPDLGAVTGAMYKLIGNGTVPQSTISLMHLRAGQIVANSYLTKMHTDALRGAGEAEDRITAVSSWADALCFTPAERAALALVEAVLTAPPAGRERVSDEVFAEAAEHYDEKALTTLILAISQVNFFIPLALIGKPLPGQAPSKQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBP6</accession>
    <name>A0A0F4JBP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948568.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000566.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4JBP6"/>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1086"/>
    <dbReference type="EnsemblBacteria" id="KJY30406">
        <property type="protein sequence ID" value="KJY30406"/>
        <property type="gene ID" value="VR44_20545"/>
    </dbReference>
    <dbReference type="GeneID" id="58474832"/>
    <dbReference type="GeneID" id="63982204"/>
    <dbReference type="GeneID" id="67394167"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8820"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21955" checksum="F3835464B689CC60" modified="2015-06-24" version="1">MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCI7</accession>
    <name>A0A0F4JCI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948539.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000486.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31519">
        <property type="protein sequence ID" value="KJY31519"/>
        <property type="gene ID" value="VR44_17995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8144"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8134" checksum="023DC562B0DBEC98" modified="2015-06-24" version="1">MSLQDDLTAVRRNLNELVRSVERLEQDVARQSPAAAPKPSGPAGMVSVPDTPYDQSKWTDTDDEGLGVRDRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD48</accession>
    <name>A0A0F4JD48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000472">
        <property type="protein sequence ID" value="KJY31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948470.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000472.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31734">
        <property type="protein sequence ID" value="KJY31734"/>
        <property type="gene ID" value="VR44_17630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="18848" checksum="216EBCEB8875F601" modified="2015-06-24" version="1" fragment="single">MGTQGRAAVPGPGGPADSPAPAPRVVRQRRRRRGLIALSVALIAAGGLSGALLFTASGQRSSVLVVARDVPVGATLTEADLAPASLALDPVVKAVPAAKRAGLVGQRAAVALKAGSLLSPGQITAVSLVKTGEQLVGVALKPSQVPASRLAPGQKVLIVSTPDPAQAGAAAAAGKPADPAPVSKTLAATVVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF50</accession>
    <name>A0A0F4JF50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000413">
        <property type="protein sequence ID" value="KJY32419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948164.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000413.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32419">
        <property type="protein sequence ID" value="KJY32419"/>
        <property type="gene ID" value="VR44_15990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7618"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12458" checksum="7B052AD7A518EDF8" modified="2015-06-24" version="1">MATAPEFDTPVLDTIAAMTIDSLEHCHMDERTLIISRIAALVAMDAPAISYMAHINPALKADFTVEQLQDLLVAIAPVVGTARVMSAAGHIAQAFGVALALAESEAEAIAQAEAASRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFH2</accession>
    <name>A0A0F4JFH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000382">
        <property type="protein sequence ID" value="KJY32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947960.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000382.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32935">
        <property type="protein sequence ID" value="KJY32935"/>
        <property type="gene ID" value="VR44_14900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7396"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8086" checksum="D78B476997773DDE" modified="2015-06-24" version="1">MSNPFENDNASYVVVRNDELQHSLWPATHPVPAGWTVVHGPDGRQACLDHVERVWTDMRPASLVAALAGNAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFL8</accession>
    <name>A0A0F4JFL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947941.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000378.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32985">
        <property type="protein sequence ID" value="KJY32985"/>
        <property type="gene ID" value="VR44_14795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7356"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="33616" checksum="2B9DE70A11CFCFD2" modified="2015-06-24" version="1">MSYNQPGPYGQQPQQPGPYGQQPPPPPNPYGQQPQQPAYGYPQQAPPPAYPQPTPPPPPGYPQQGGYQTPPAPQPAYGYQQQPPQQGYMPPPAPPKKSKAGPIIAVIAVVAVIGGAGWWFLGGSGGVSDATKGYKLAFPAAVDSYQKAPDATGAAAASEAPLTGDKKTKAEALGVQNAHSANAKYQVGTDPKGKSLSASGLWGDIADPAKAIDNYYAGLSQNNPEAEKIGFKYEVVGTPKEFSPAGFKGAVMKCAYVKLVNLKPAATGKEPKEIQVPSCAWGDHSTLVGVNAIDPAVLLVGGSSGTLDEVAALAAKLYNTSRTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGF4</accession>
    <name>A0A0F4JGF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32894">
        <property type="protein sequence ID" value="KJY32894"/>
        <property type="gene ID" value="VR44_14930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="15005" checksum="A182499703A76ACF" modified="2015-06-24" version="1">MVLGDEELEPGVGEPLDVEPDQRGPVPVEGPVALGGVAGGDGGALRLGVEAVQVLEGELRAGAVVDELEGLGESVRVEGGAQHLVPGREDLDGGPPGLLGEGRFDQVGGHVVVNASAGRGQVAVVEHAGLEPGHRVGVLQSRGQGGAIGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHN2</accession>
    <name>A0A0F4JHN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000411">
        <property type="protein sequence ID" value="KJY32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948151.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000411.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32451">
        <property type="protein sequence ID" value="KJY32451"/>
        <property type="gene ID" value="VR44_15925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7594"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="110"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="37221" checksum="5CB14669671AC3B0" modified="2015-06-24" version="1" fragment="single">VTVRIAVHYDGVSGRLDPGVFLGPGVRLDHLAAGPHHVELVLTAQPWGRWTLGTVDVDVYDRGGLARRTIRADLGEISVFPVPEHAGLTPIPVRLPQRLGEHTSAQRGEGVEVTGVHPYARGERQRRIHWPATTRRGTLQVHGFAAERTAETVVLLDVLTDVVDPVTGTSTLDATFRAAAGLVRAYLRTHDRVGVVSIGGATRWLQPGSGQGYFYRIAESVLAVRKDRSHRSEGLGTLPPPALPAGALVYVITPLTDQRIFDVLHQVRGRSNPVVVVEIPTGDPVVDPGDTEGELALRLWRADRDAMRFSLVESGVAVVAHRPGETLDLALAPLLRTRVQGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIS3</accession>
    <name>A0A0F4JIS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32866">
        <property type="protein sequence ID" value="KJY32866"/>
        <property type="gene ID" value="VR44_15095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7438"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470966" evidence="2">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16575" checksum="19B9E5B36C7537EF" modified="2015-06-24" version="1">MLRMTAGLATAAVTALVPSSCGAGKPVITPKAVTHSELVGRWDGEPRCGSPIFRLRDDYTFSSKDFPVQWDGPEPDSQVTRRSSAGEWHGVNKDPGLPPYLVLSFSGHADIQILHFFLEHGELRIDGTVYADGGDPYAYRCHYKRGSADPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIZ4</accession>
    <name>A0A0F4JIZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947686.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33748">
        <property type="protein sequence ID" value="KJY33748"/>
        <property type="gene ID" value="VR44_13360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6908"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="14"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="32691" checksum="D48390533849BFAC" modified="2015-06-24" version="1">MGVSRPSPAAVLALDAGNSKTDAVLVGADGTVLGTGRSGGFQPPRTGVGAAVDVLGEAVAAAARAAGLAGPPYAFRVSACLANADLPVEERQLADAIAARGWAEAVEVRNDTFAVLRAGVDRPRGVAVVCGAGINCVGMLPDGRTARFPALGRISGDWGGGGGLAEEAVWWAARAEDGRGGPTGLAKALPGHFGLGAMAGLIEAVHLGGIPRGRLHELVPVLFAVAAEGDAVASAIVERQAEEVVALASVALERLGLLAEEVPVLLGGGVLAAGHPQLNGRIGELLSARAPRARLSVVTAPPVLGAALLGLDALGAPAGAHGRLRNQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ33</accession>
    <name>A0A0F4JJ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000335">
        <property type="protein sequence ID" value="KJY33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33824">
        <property type="protein sequence ID" value="KJY33824"/>
        <property type="gene ID" value="VR44_13150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6693"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26159" checksum="5311ED234AA8AFC0" modified="2015-06-24" version="1" fragment="single">AVLLGLDPDAADDRPAMLDAFEADLLRVFGGTDGPPRHPLLLALQPVVREHRLSPEHFLGLIEANRQDQRVARYATYGELLAYCELSANPVGRLVLELTGTATPERIRRSDAVCTALQIAEHLQDVTEDLARDRIYLPAEDMRRFHVAEADLRAPSAGASVRSLVAFETERTYGLLNEGTPLVGSVHGRLRLLLAGFVGGGRAALRAISAAGFDVLPGPPKPTRGLLLREVAAVLRTAPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ37</accession>
    <name>A0A0F4JJ37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947667.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene707"/>
    <dbReference type="EnsemblBacteria" id="KJY33793">
        <property type="protein sequence ID" value="KJY33793"/>
        <property type="gene ID" value="VR44_13250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6869"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="34076" checksum="62E4728778B74316" modified="2015-06-24" version="1">MTATAAPPQAEAPAVPPVHRASLKKRLIPYWLLLPGIVWLLVFFVLPMVYQASTSVQTGSLEEGFKVTWHFQTYWDAFTEYLPQFLRSLAYAGTATVLCLLLGYPLAYLIAFKAGRWRNLLLVLVIAPFFTSFLIRTLAWKTILADGGPVVAVLDKIGFLDVTSWLGITEGSRVLATPLAVVCGLTYNFLPFMILPLYTSLERIDTRLHEAAGDLYATPATVFRKVTFPLSMPGVVSGTLLTFIPASGDYVNAELLGSTDTRMIGNVIQSQYLRILDYPTAAALSFILMAIVLIMVTVYIRRAGTEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJV2</accession>
    <name>A0A0F4JJV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_12770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34043">
        <property type="protein sequence ID" value="KJY34043"/>
        <property type="gene ID" value="VR44_12770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6635"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="140"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="396"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="495" mass="51038" checksum="1863458686E67066" modified="2015-06-24" version="1" fragment="single">LPAGDLVIAPGTIVAALLIGVVVTTLAALLPAWRTGRIAPVAAMGSAHLPATAKSLVVRNVLGSLISLAGIGVVFLGVSMGGDGRMVIGGGAGLMLIGMIVLLPLLSRPVIGAVRPLLHKVFGVPGKLAAQNAVRNPRRTAVTAASLAIGLTLVTTLSVLGVTMGTAVDRMSTDKLKADYKVSMAGGIGGLDKSVADTLAKAPGIKAVSPQADGYFKVGDSFRSASGVNPATIGELLNIDVTAGSLAALGKGEAAVAESTAKKQNLTVGSTLQVQFEDGQKSALKIGAVYKDLEGLLSPYVLDNKVLGAHTDQQYVREVYVNTTAGDSKAGQQAVIDALGKNPAMTVADRQDMRNEMGGIINTMLNIMYGLLGMALIISVLGVVNTLAMSVFERTQEIGMLRAIGLDRARVKNMIRLESVVISLFGAVLGMGIGLFLAWAVGTTLTKAVPNYELVLPYGRLGIFLLLAAVVGVLAAMWPARSAARLNMLTAIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK32</accession>
    <name>A0A0F4JK32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947538.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34123">
        <property type="protein sequence ID" value="KJY34123"/>
        <property type="gene ID" value="VR44_12555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6572"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="364" mass="38840" checksum="84F359F3AF077D32" modified="2015-06-24" version="1">MHSSAPDVTPPARTTLSGLVGNTPLLRVCEPLSPAGRGFWAKLEGFNPGGIKDRPGLHMVERARARGDLEPGARIIESTSGTLGLGLALAGMVHGHPVTLVTDPGLEPSMTRLLTAYGAQVDVVSEPHPTGGWQQARRDRVTELLGHHPGSWCPDQYNNPDNTTAYTPLALELATELGHIDVLVCSVGTGGHSAGVSRVLRQLYPELKVVGVDTVGSTIFGQPARPRLMRGLGSSIYPRNVAYEQFSEVHWVAPGEAVWTCRQLASSHYATGGWSVGAVALVAGWLARTLPPQTRIAAVFPDGPQRYLGTVYDDDYCAAHGLLDAPPAPEPDTIGRLDEKEVTRWTRCAAVVDPLTLTRAEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKE4</accession>
    <name>A0A0F4JKE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000261">
        <property type="protein sequence ID" value="KJY34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34812">
        <property type="protein sequence ID" value="KJY34812"/>
        <property type="gene ID" value="VR44_11260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6263"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="14409" checksum="5B2F33F3AD561E3A" modified="2015-06-24" version="1">MAALQDRQVLLMLYGRGPDRPPTDPNGFRERVEQLGSSAMSELAAHIGPNTPIHPYAKLINRRKLYHRMPSWPDRFLVLMSRVGHSPQLHRALLQIYQLLPPTSLCDPRAVLAACRPGRLVRRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL03</accession>
    <name>A0A0F4JL03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947727.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33646">
        <property type="protein sequence ID" value="KJY33646"/>
        <property type="gene ID" value="VR44_13590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6979"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="48665" checksum="20892A63BC677439" modified="2015-06-24" version="1">MPVTSDTPLLLARLRSALPAEALLTAPAELAAHSRDTAPFSACGTPAVVAVPRTAEQVEHIMRTAYELDVPVVPQGARTGLAGAANAVDGCVVLSTAALDRILSVDPANRLVRCEPGVTTRRLAEAVAGYGLAYPPDPASWETCTIGGNIATGAGGICCVKYGVTADYVLGLDLVLPDGRRMRTGRDTAKGVAGYDLTRLVVGSEGTLAVVVGATLALRPARPPALSLLAQFPTLTAAGDAVAAITRAGHTPSALELLDRATTRAIADLGAHPLVRPGSAATLIVESDGADPSADLTAMELLCKEAGSDHVATSATAEEAREIIEARRLVTPAIGAYMASRGGGLTAFIEDVAVPRSELPKLIGQIEDIAARHRLQVFTLGHAGDGNLHPTVVFDPSDPGELDRARTAYDDIMAAGLALGGTTTGEHGIGTLKREWLERELGPVSLELQRGLKRLFDPKNLLNPGKVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLU0</accession>
    <name>A0A0F4JLU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947197.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35160">
        <property type="protein sequence ID" value="KJY35160"/>
        <property type="gene ID" value="VR44_10755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5900"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="40647" checksum="4B84714E8CF30C96" modified="2015-06-24" version="1">MTTPDTLEHPVPPGRPGHLYRAVSDRPYFSADGETYLSPVRLRDLRKTRPLRVLSEQDFAAWQTYGYVIVRNAISRTAARRLLDFAWEFQGLDPARPDGWYAEREFRSELDRHLYVYGFVEAYHHQLIWDSRQTRRVYEAFVDVWDCEELWVTLDRLNLNPPNVGNRDRALIEPTDRGFDIDLHWDVDTTLGVPPQRVQGIIALDDTHPETGGFQCAPELFRRFDQWQAAQPAGRDPVRPAIDRAEFPVIRPELAAGDLLIFNGHLAHGVAPNTSADRVRAVQYLSMMPALEEHTRLRTSRVDSWRRLATPDWNATLVGDATRHESLRYGRATLNGLGRRLLGLDPWGPAPAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JML4</accession>
    <name>A0A0F4JML4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ORF">VR44_11030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34993">
        <property type="protein sequence ID" value="KJY34993"/>
        <property type="gene ID" value="VR44_11030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6090"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="140"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-106)" evidence="8">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY34993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="741" mass="80165" checksum="88CFE7B8BB93585E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMR6</accession>
    <name>A0A0F4JMR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947498.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34246">
        <property type="protein sequence ID" value="KJY34246"/>
        <property type="gene ID" value="VR44_12350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6455"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471064" evidence="1">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="116"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="35153" checksum="5276282ED1DE885E" modified="2015-06-24" version="1">MRHPLVPLGALAGAAALLATGCSTAPSPAGGQPPAAASRAAAAPVVAPKSPAEVGANELGQVPVLMYHQLTEKPASVYDRTPADFRAELERLAREDYVPVTARDFQTGRIDIPAGTHPVVLTFDDSTNSQVRLGADGAPAPDTAVAILAETAKKHPAFKPVATFFVNADAFSATGSAKALTWLKDHGYEVANHTGRHENLHSLDRAGAERAISAGQQAIERAAPGTRVTSLALPFGAMPEPAGTAVRGTGYHYDGVYLVGANPSVSPFAKGFTPGAIPRIRSAGPKDEDAEFGSSRWLDKLAAGHSRYVSDGDPATVAFPRAAQNELAPAFAQRARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMS2</accession>
    <name>A0A0F4JMS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947089.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35485">
        <property type="protein sequence ID" value="KJY35485"/>
        <property type="gene ID" value="VR44_10160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5632"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470673" evidence="1">
        <location>
            <begin position="32"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="80"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="56481" checksum="9EEFB5E130FDAC97" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN50</accession>
    <name>A0A0F4JN50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35615">
        <property type="protein sequence ID" value="KJY35615"/>
        <property type="gene ID" value="VR44_09790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5458"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046245">
        <property type="entry name" value="DUF6278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19794">
        <property type="entry name" value="DUF6278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16117" checksum="5B0706D6F8563819" modified="2015-06-24" version="1">MRIPFLANWLHRDETQQGAVGLAAALADDPEGIGELFAECEMLRAQAWAEGLELDQTPASLEALDQLMPRWRRDPEAVPWLGNDAGFYLGTVIVRTVPGTGWQVRPDRQPVIRLASGRELNVIESGVSWAMTGSPELSQAYAEASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNJ7</accession>
    <name>A0A0F4JNJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000230">
        <property type="protein sequence ID" value="KJY35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947135.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000230.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35338">
        <property type="protein sequence ID" value="KJY35338"/>
        <property type="gene ID" value="VR44_10395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5953"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="14352" checksum="083AC837CD3E6C50" modified="2015-06-24" version="1">MTATFNHTIIAAKDRNESALFFRELLELSEAPSWGPFTNVRFADGVLLQFAEPPVEIQMQHYAFLVDDELFDRAHRMLRDRGIEHWADPQMRRPGETNTEHNGRGVYCKDPGGHLIELITRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP06</accession>
    <name>A0A0F4JP06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946808.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene958"/>
    <dbReference type="EnsemblBacteria" id="KJY36102">
        <property type="protein sequence ID" value="KJY36102"/>
        <property type="gene ID" value="VR44_08595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4861"/>
    <dbReference type="eggNOG" id="COG3654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="13498" checksum="91C8359C2DB4F14E" modified="2015-06-24" version="1">MEWAWTALAHHLPSDPAVWDPSGVAAAVARHQNDLVLVPEQPAPDTAWRAAAFLHTLAVCPALESPMNEFYAAAATRSYLRVAGAKQLPSPEELGDLVEDAKLGRADVSAVAQQLRALIQEPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ41</accession>
    <name>A0A0F4JQ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000166">
        <property type="protein sequence ID" value="KJY36320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946727.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000166.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36320">
        <property type="protein sequence ID" value="KJY36320"/>
        <property type="gene ID" value="VR44_08200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="31820" checksum="29F24CFB28E24F69" modified="2015-06-24" version="1">MSAAHTPRWNPVTELAPQELRVLVAVAETGGFSAAASRLGISQSAVSHSVRGSEGKVGTVLFERGRSGASPTPAGERAVALGRRILRLYEALGAEARAAGRAASGGGTAGGALEGTLRIAAFRSAALHLLPPALERLAALHPGLRPEVRVVRELGAGTAGEVAAGRADLGIATLGASGDVPPGLLTGVLTREAYALVHPAGHPDPKALPLLDWDENCGSYTRRWWAAQDWIPAATVKAEDDAMVLTMVGRGLGMAIMPELSLREATDAVEIAALGPQGPVRQVGYVTTPESAATLGVRALIRELRAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQD6</accession>
    <name>A0A0F4JQD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000241">
        <property type="protein sequence ID" value="KJY35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947204.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000241.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35146">
        <property type="protein sequence ID" value="KJY35146"/>
        <property type="gene ID" value="VR44_10765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5903"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471257" evidence="2">
        <location>
            <begin position="27"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="437" mass="47231" checksum="6476C03DDACEAEFE" modified="2015-06-24" version="1">MARRLRRAAALLAGLLLLSPATAANAAAGGSSPARELTVWLMWGSVPQPELDRLTGEFEQAHPGVTVNVRMQGWPGIDERLETALNSDAPPDVVETGTTTTPYFAAKGLLKDLSDQSGRLGAAEWIPSLRESGNWQGRQYGIPLYAASRVVIYRKDLFEEAGLTRPRDQKEWLRTNRTLARAHRAEPGFQPLHLPGQNWYVLSGFLHDRGGRIAEYDGMRWRGGLSTRPAVEALEYYQALQSFSRAPKDQDEAHPLQYEVLAKGQTAQMIGLPWELADAERINPALRGKLDMFPVPGTSADRPGSVFLGGSNLAVAQRGRQPDLAADWVAALTGPAFQERLATANGVLPNRLALAGTIDNPGVRVQAQAAANAHTTPVDPRWPTVEAAPNPVKTLLTDVLTGRPPRAAGRRADAVLEERLNAGPPPDGNTTAPGTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQK2</accession>
    <name>A0A0F4JQK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_07595</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946606.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36642">
        <property type="protein sequence ID" value="KJY36642"/>
        <property type="gene ID" value="VR44_07595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3996"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="177"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="393"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY36642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="588" mass="64875" checksum="0A9B56BC75355BAB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRT1</accession>
    <name>A0A0F4JRT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000121">
        <property type="protein sequence ID" value="KJY37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946438.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000121.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37067">
        <property type="protein sequence ID" value="KJY37067"/>
        <property type="gene ID" value="VR44_06620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3242"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="33024" checksum="2A00C16ECD987573" modified="2015-06-24" version="1" fragment="single">AGSLRRTDSNAFVDELIGKGLAASYVHQVFKTWRIFVHWMVDEKEIPLPANIVSRIKLPEIPKRKVVDLTPQQVARIAECIEPRFEVLVWEAACGGVREGEAFGMTKDRVDFLRRRWHIAEQRQKGQAVKTKTKASMTWVSVDQFLLDKIAAHLAAGYDRPAQVQHATELRRIRRQAQGVWTPPVDEGLIVTNHAGRPLTRQTFHPYWREAVEEAGVDPDARFHDLKGFYTRTLATSGNHDPKTVQRLSRHARFEETWDTYAETGAGAEDVKVIAFSSAFTATGDEDPSAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSY5</accession>
    <name>A0A0F4JSY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic immunogenic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946496.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36883">
        <property type="protein sequence ID" value="KJY36883"/>
        <property type="gene ID" value="VR44_06950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3605"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="25985" checksum="98205F2B11F34AD1" modified="2015-06-24" version="1">MTQDATHTPPTAHQPYGTPEVPRVAVRGEARLEVDPEIARIGITVTARGTDRRTALEDLTRRNNTVLDLVKSYGDPVEKLETGAFSITPEPTRHGRGERIRAYHGTVHITAELNDFTALGELTTRLADLELTRVDGPWWALRPTSPAHGEARRQAVLEAVQRAREYAHALGADLAALVELADLGAENAAPLAMAAPAGIHRSLTFAGTEDGGAPPLDLEPQRQTVHAQVNARFTMTPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT56</accession>
    <name>A0A0F4JT56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000101">
        <property type="protein sequence ID" value="KJY37542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946224.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37542">
        <property type="protein sequence ID" value="KJY37542"/>
        <property type="gene ID" value="VR44_05500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1737"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1536" mass="162624" checksum="EE758AA89ACD6A85" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTE2</accession>
    <name>A0A0F4JTE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37099">
        <property type="protein sequence ID" value="KJY37099"/>
        <property type="gene ID" value="VR44_06545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3223"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1341" mass="146840" checksum="BDBDF9291DA14670" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUE0</accession>
    <name>A0A0F4JUE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mca</name>
        <name evidence="3" type="ORF">VR44_07725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5536"/>
    <dbReference type="EnsemblBacteria" id="KJY36591">
        <property type="protein sequence ID" value="KJY36591"/>
        <property type="gene ID" value="VR44_07725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4157"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="31881" checksum="7D743E20F91A0819" modified="2015-06-24" version="1">MTEDPVLTEQLRLMAKYVSEGVPVLVVTCTGGERGSVLNPKLQGDKYIEENIHEVRAKEMDEAREILGIEQEWLGYVDSGLPEGDPLPPLPEGCFALADVEEAAGELVKKIRAFKPQVITTYDENGGYPHPDHIMTHKITMVAFDGAADTDKFPEAEYGAPYQPQKLYYNQGFNKPRTIALHEALLARGLESPYGEWLERWKEFERKERTLTTHVPCSDFFEIRDKALIAHATQIDPDGGWFRVPMEIQKEVWPTEEYELAKSLVDTSLPESDLFAGIRENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUJ8</accession>
    <name>A0A0F4JUJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946105.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37860">
        <property type="protein sequence ID" value="KJY37860"/>
        <property type="gene ID" value="VR44_04850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1051"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470892" evidence="1">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="44"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25151" checksum="2627C3B39315D2B6" modified="2015-06-24" version="1">MSDFNRRHLLATTLTGGAALAAGWTAAAPAAAAPAPSRASGPLRVHLVAFDGVEELDLFGPLEVFALAAALGRPVVPTLVTTGRPGRVRAAFGTQIEVPGRWDPSSADAVVVLGGGYRKRDGAGVWAEIDKGTLPQALRRAVRPGLTLVGVCTGVFLLHAAGLLDGRPCTTHVRAKQDLRDLGHDVRDARVVDDGDLVCAGGVSSGIDAALWLLERELGSEAASGVETLLEFERRGTVLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVU8</accession>
    <name>A0A0F4JVU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_04740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946083.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37883">
        <property type="protein sequence ID" value="KJY37883"/>
        <property type="gene ID" value="VR44_04740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1028"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="948"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1269" mass="138625" checksum="596AAC1FF6DAABA5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW35</accession>
    <name>A0A0F4JW35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000085">
        <property type="protein sequence ID" value="KJY37938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37938">
        <property type="protein sequence ID" value="KJY37938"/>
        <property type="gene ID" value="VR44_04670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1015"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="30404" checksum="F9FA61CB6737E4C9" modified="2015-06-24" version="1" fragment="single">GQANYAAANAFLDGLAVRRRASGLPGTSLAWGWWEQSSAMTEGLDRADRSRLRRTGIAPMPTPEALALFDAACASGEPVLIPARVDLAALRGRPDGELPPLLRGLADGARPRRDRAATADTGPSGLPAGLSALPADEAGTAVLDWLRDRAAVVLGHPAGTTIDPEQPFTQLGFDSLTAVELCNSLAAATGLRLPSTLVFSYPTPRELAGHLLGLLRPAPDGEPERASDAEIREVLRTVPVDALRRAGLLEAVLACAAPAGAPEEPAQEAAGTEELAGMDLDALLDLALDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXE8</accession>
    <name>A0A0F4JXE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_02455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945662.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39037">
        <property type="protein sequence ID" value="KJY39037"/>
        <property type="gene ID" value="VR44_02455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6781"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="457" mass="48211" checksum="823BAE9472DA22B1" modified="2015-06-24" version="1">MSEVTTTDLYEVTMAMSYLREGMCAEATFSLFVRDLPPERGFLVAAGLEPALDYLSRFVVTADDVRVFAEALRRPTADLAQLVGLRFGGEVRAVPEGRLVFAGEPLLEVTAPLPQAQLVETYLLGQVCHQTAVASKAARCVLAACGRPVVDFSLRRCHGPQAGFQAARLGGIVGFAGTSNVDAAVRLGLDASGTMAHSYIESFPCEEDAFRAFARTHPGPVTLLVDTYDTDRGVAAAARVLNGLRRGPGCAIRLDSGDLGQLARRSRVQLDAAGLTDVRITASGGLDEYAIDELVRSGAPIDVFAVGTRVGIAADAPYLDAAYKLVAYDGRPVMKLSSAKATAPAAKQVYRRPGSPDVIALRDEASPPGSVPLLATVMLHGRRTGPSDSLAAARIRFEADLDALTQEARRISGPRPPAPTVSEGLSRLTGEVRGRLLRDPGVPSAVRVTDGIPPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXF1</accession>
    <name>A0A0F4JXF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000047">
        <property type="protein sequence ID" value="KJY38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945735.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38835">
        <property type="protein sequence ID" value="KJY38835"/>
        <property type="gene ID" value="VR44_02780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7286"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="623" mass="66182" checksum="2E4E9982320CF241" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXF2</accession>
    <name>A0A0F4JXF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945668.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39042">
        <property type="protein sequence ID" value="KJY39042"/>
        <property type="gene ID" value="VR44_02345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6758"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018723">
        <property type="entry name" value="DUF2254_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10011">
        <property type="entry name" value="DUF2254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="48393" checksum="66AFF879060D0781" modified="2015-06-24" version="1">MPMTVVRRRRGVFPRLRKRMRNSFLFVPFAGLLIGWVLAAVVVRADSLIHDLDARWTGVDLSGLWFLRTAADFGSAARTAVAAVSSAMLTFIGVVFSITLVALQMAAGRFSPRVLRIYVESRVTKLTLGTFLCTFLYTLRVQKEYGSAGEGSDVVVPYLGSSLTMGFLLLSLALFVVYVHSTIRLMRVTYVMDRVCQESLRLIRDSAGPARAAAGDAGERGADPGGTTVGHVWRPGVLQAVDVPRLVALAARDGLVVHLVPRIGDYLVPHAPLFRVTGGPAPSDADLQAALELGVERTTEQDLAFGIRQLADIASRALSPAVNDPTTAVQALDRIQVLLTALARQPLGRAYHRDADGAVRLVETLPSWPELLDLGLTEVRDYGIGSVQVTRRIAACLDDLERLAPPDRREPVRRHRDLLEEAVHTTAATPQRAAFALQPDRQGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY78</accession>
    <name>A0A0F4JY78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000034">
        <property type="protein sequence ID" value="KJY39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945638.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39085">
        <property type="protein sequence ID" value="KJY39085"/>
        <property type="gene ID" value="VR44_02275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5720"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471353" evidence="2">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="28573" checksum="043C85273B25D5E7" modified="2015-06-24" version="1">MRTYLSAALIVLVALLVPASAIAYWADRQLGDADGYTAAMSPLATNPAVQGVVVAQAGRALSGQIDAGPFQGGVDALLGEALRSFAGTPAYRTAWDAANRAAHTAFLEALTSGHGDAVTIDLAPVIARVKGELVADGVPFADRIPETHLSVEVMEYDNLGALRKGFRMLQIAGVWLPVLTLLLAVASVAVAVRRRRAVLATGLGIAAGAVLLGIAVAVCRRLTLDDLPADIDRAAAGAVYDALTAFLRTTAWVVLSVGLATALTAWLMGRLRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYQ0</accession>
    <name>A0A0F4JYQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945482.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39492">
        <property type="protein sequence ID" value="KJY39492"/>
        <property type="gene ID" value="VR44_01430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4718"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471482" evidence="2">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="16308" checksum="3265A770189A774B" modified="2015-06-24" version="1">MKMTARGSIAALMTCMAAAAAASPAAAATVPVGVPLDAVETTLGVPTPQVGTAVPMPVVGAPEAPVLHKGDLLPNPLLPAVPVATDLGLTKVVSPVPNLLGSKETDGEGSLESPATTLLTRTPGAVVGAPLTMPDAGNRGIPNLTAPKLGVVAPEIIGAPSALLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ24</accession>
    <name>A0A0F4JZ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000041">
        <property type="protein sequence ID" value="KJY38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945705.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38948">
        <property type="protein sequence ID" value="KJY38948"/>
        <property type="gene ID" value="VR44_02625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6831"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045560">
        <property type="entry name" value="LigC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19858">
        <property type="entry name" value="OxRdtase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OxRdtase_C" evidence="2">
        <location>
            <begin position="156"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="34697" checksum="6EDA5A04BEB78065" modified="2015-06-24" version="1">MSDDRTLRVALAGGGAFGAKHAAALKRIEGVEVAAVVSSSLDSARKFAAEQGVGRAVASLDEVLAMEDVDAVVLATPTPLHAEQTLACLDAGKHVQVEIPLAASLADAEACLEAQRRTGLVAMVGHTRRFNPSHQWVRRRIQTGQFDIQQMDVQTYFFRRTNLNALGAPRSWTDHLLWHHAAHTVDLFAYQTGSPIVQANAVQGPVHPELGIAMDMSVQLRAANGAICTLSLSFNNDGPLGTFFRYIGDTGTYIARYDDLVTGKDEPIDVSGVDVSMDGIELQDREFVAAIREGREPNSSVAQVMSCYRTLAALEAQLDAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ40</accession>
    <name>A0A0F4JZ40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_00845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945374.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4775"/>
    <dbReference type="EnsemblBacteria" id="KJY39667">
        <property type="protein sequence ID" value="KJY39667"/>
        <property type="gene ID" value="VR44_00845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2875"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="249"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY39667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="376" mass="39853" checksum="363DB9F79513534D" modified="2015-06-24" version="1">MKIRVERDVLAEAVAWAARSLPARPPVPVLAGLLLKAEDGTLSLSGFDYEVSARVSVEADVEEDGTVLVSGRLLADICRALPNRPVEISTDGVRATVVCGSSRFTLHTLPVEEYPALPQMPTATGTVPGEVFASAAAQVAIAAGRDDTLPVLTGVRIEIEGDRVTLASTDRYRFAVREFLWKPENPDASAVALVPAKTLLDTAKSLTSGDTVTLALSSSGQGEGLIGFEGAGRRTTTRLLEGDLPKYRTLFPTEFNSVAVIETAPFVEAVKRVALVAERNTPVRLSFEKGVLILEAGSSDDAQAVERVDAMLEGDDISIAFNPTFLLDGLSAIDSPAAQLSFTTSTKPALLSGRPAVDAEADEAYKYLIMPVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZE4</accession>
    <name>A0A0F4JZE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000034">
        <property type="protein sequence ID" value="KJY39083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945636.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39083">
        <property type="protein sequence ID" value="KJY39083"/>
        <property type="gene ID" value="VR44_02265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5718"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6602" checksum="784DBA619B3E5B7E" modified="2015-06-24" version="1">MPIDPYAALNAMIRAEAVRFSPAAREGRPAAQAPAPQNHRDTAPEAPGTAADGEPQRPTADPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0V9</accession>
    <name>A0A0F4K0V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4689"/>
    <dbReference type="EnsemblBacteria" id="KJY39563">
        <property type="protein sequence ID" value="KJY39563"/>
        <property type="gene ID" value="VR44_01280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2973"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="14788" checksum="5A4C8E299405F533" modified="2015-06-24" version="1">MREQLRISGVSESVVDDAVLILSELLSNACRHGRPLGARDVGDGEIRAAWRVDKAGRLTVEVTDGGGPTRPVPATPSVTAHGGRGLNIISALAQDWGVRDGAAGEVTVWVIVARGPRHDDFATRVAPPAIDFAAAFDDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3F0</accession>
    <name>A0A0F4K3F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_00800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945365.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39711">
        <property type="protein sequence ID" value="KJY39711"/>
        <property type="gene ID" value="VR44_00800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2865"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="38005" checksum="3D28BAE492D64077" modified="2015-06-24" version="1">MGEVFAGRYELADPVGRGGAGAVWRAWDRRRGRYVAAKVLLRAEAPMLLRFVREQALRIDHPHVLAPVSWAADDDKVLFTMDLVGGGSLAHVVADYGPLPPHFVCVLLDQLLSGLAAVHAEGVVHRDVKPANILLEATGKGRPHLRLSDFGISLRKGEPRLTDTDLVVGTPGYFAPEQLRGAEPDFPADLFAVGLVALYLLTGRKPDSPALLERFPAHGVPEAPEGVPAPLWDVIANLLHPDPRNRFRTATGARKALAEAAQLLPEPPADEEPVEVFDQLGPLPPGFGPEGPLSTPVREDPPQPAPAAPDTTGYHLAPPAPAATRRVPPPSPKVTAAILTAALLCFTTAGWALTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3P1</accession>
    <name>A0A0F4I3P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001792">
        <property type="protein sequence ID" value="KJY16073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16073">
        <property type="protein sequence ID" value="KJY16073"/>
        <property type="gene ID" value="VR44_40615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="12614" checksum="A77ACCA5FF2E65A5" modified="2015-06-24" version="1" fragment="single">LMRRLGAYEALNLDGGGSATLLAAHPGAGALTLENSPSDGHPRPVPNGLVLTAPAGPGPLAGFDVQPAGGATRLFPGLTRTLTATPYDATLAPAAAAPRWSTDRGRIGQDGVYRADRPGPAVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I545</accession>
    <name>A0A0F4I545_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001733">
        <property type="protein sequence ID" value="KJY16593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16593">
        <property type="protein sequence ID" value="KJY16593"/>
        <property type="gene ID" value="VR44_40365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="23775" checksum="119D57552CB54C4E" modified="2015-06-24" version="1" fragment="single">PVAVQGVVGGTGRFAQAVAAASGARILTGTTARALSLSTSGRWSVRAHTGGGPLTLTADAVVLALPAFAVAELLLPHAPLAGEELAAIPHASTAVITLAFSRARAHRLPEGNGFLVPPVDGRTLKAASFLSNKWAWLGAAAPELFVLRASVGRIGEEALLELPDKELVRRAVGELHRAAGPLGEPVAARVTRWDRGLPQYGVGHHDRVARIREAAGKLPRLGLCGAAYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I575</accession>
    <name>A0A0F4I575_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001821">
        <property type="protein sequence ID" value="KJY15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15906">
        <property type="protein sequence ID" value="KJY15906"/>
        <property type="gene ID" value="VR44_40690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="8239" checksum="33440E0DC79E9692" modified="2015-06-24" version="1" fragment="single">APTEAVAQPEAPAAGATPADTVLQAADAPEAPAAPADPAAVADVPAQQAPEAAEAAQTVAADTEPAPADGEAAAEAPAEPRPSVGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8A0</accession>
    <name>A0A0F4I8A0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001641">
        <property type="protein sequence ID" value="KJY17884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17884">
        <property type="protein sequence ID" value="KJY17884"/>
        <property type="gene ID" value="VR44_39800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="133"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY17884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="24805" checksum="20B22EDA64A06E7C" modified="2015-06-24" version="1" fragment="single">LDALAEQRRARGLAATSVAWGPWADGGMAGDEQAEAHLRRRGLPAMAPDTAIAALQRAMDLDETTVVVADVDWQRFAPAFTLARPSALLAGLPEARTALAAAGDGADTAGTAEGTAPSRTAGLAALPDAERHRVLLDLVRAEAARALGHPDLAAVASDRSFKDLGFDSLTSVELRNRLNGATGLRLPATLVFDHPNAEALAAFLSAEVSGHAPAALPATGPAPAGPAGPGAPDEPIAIVAMGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8J9</accession>
    <name>A0A0F4I8J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001698">
        <property type="protein sequence ID" value="KJY17026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17026">
        <property type="protein sequence ID" value="KJY17026"/>
        <property type="gene ID" value="VR44_40180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="7382" checksum="C5A6B7E6CA309C74" modified="2015-06-24" version="1" fragment="single">MRAGAGVGSPGPGAPSVRAGPASSGVTGPGVGAPGASPGAGRLPAPAVQPSARARARAGAGAAAVRAGAGAVGFVLSGRFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJG3</accession>
    <name>A0A0F4IJG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001440">
        <property type="protein sequence ID" value="KJY21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21844">
        <property type="protein sequence ID" value="KJY21844"/>
        <property type="gene ID" value="VR44_38135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="17164" checksum="729AEB64D6ACDC0A" modified="2015-06-24" version="1" fragment="single">MDEIVEALLSEDVLPEDLAALPLPEAYRGNVVHRDETGMFEGIPSAEKDPRKSLHLREVPTPEPGPGEALVAVMASAINYNTVWSSIFEPLPTFGFLERYGRLSELTRRHDLPYHVLGSDLAGVVLRTGPGVNRWKAGDRVVAHCLSVELESADGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJI1</accession>
    <name>A0A0F4IJI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001431">
        <property type="protein sequence ID" value="KJY22152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952249.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001431.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22152">
        <property type="protein sequence ID" value="KJY22152"/>
        <property type="gene ID" value="VR44_38040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5174"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469983" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="17655" checksum="13F25969EDF2EE99" modified="2015-06-24" version="1">MRIRHSLALVLALAAGAVLVTGCGGGAAPEPKGWEPEDALQRADESLGKDVAAGARVTMRGTGFLKAGMDKTLETGGERPFRFDIACDSEESSRVTLLLSREGGSGDRSFDVSCTAGEVTRLNLPAGSALNAHIDPAPQEDSPPAGVVSWQLLTLDPEAVQGCPDALAGCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IL06</accession>
    <name>A0A0F4IL06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001461">
        <property type="protein sequence ID" value="KJY21306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21306">
        <property type="protein sequence ID" value="KJY21306"/>
        <property type="gene ID" value="VR44_38325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5275"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="19223" checksum="D42008EA40A6FFE3" modified="2015-06-24" version="1">MDTGTPATGAFGALLYGLRRRAGLSQEELAHAAGVSVRALSYMERGRSRGPQRRTVQALAEALGLDPEGARELEHTRAWAARAGPAPRRPRPPPQDRTRPRGPPRRICCRARRAASTGGRRSSPPCPGPPRARRPSAWWSGPPGSGRRPSYCTGPTRAVPDSPKGRSTPTCAGSVTPASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ01</accession>
    <name>A0A0F4IQ01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_36315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001292">
        <property type="protein sequence ID" value="KJY24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24105">
        <property type="protein sequence ID" value="KJY24105"/>
        <property type="gene ID" value="VR44_36315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4513"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="64"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="22409" checksum="E5818D1531F73CC1" modified="2015-06-24" version="1" fragment="single">SPPPGGGYPPPGGAGGGGYPPPPGGPAGGGGYPPPPPPPHGGGPGDPYGGYGMPDPLAGMPPLADTGKRLVARLIDLVVVFVPLWLILFAIGFALPRDTDQNGELTDSASRWFTGAALLWWLVYVAVWIVYDWFFTQKSGQTLGKKAMRLRVAMLNDGSVPSSGSALGRAATLWVPVFLCCGLWWVVVGISILVDQPYKQGLHDKAAKTVVVSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQG0</accession>
    <name>A0A0F4IQG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_37500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001381">
        <property type="protein sequence ID" value="KJY23718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952143.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001381.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23718">
        <property type="protein sequence ID" value="KJY23718"/>
        <property type="gene ID" value="VR44_37500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4919"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470311" evidence="5">
        <location>
            <begin position="34"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="6">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="179"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="32018" checksum="C84B8BA569AE5392" modified="2015-06-24" version="1">MIRALRRRALSLATAAAAALGLAAALPAPPAAAAPACAGAWSSSAVYTSGTSASYGGHNWQAKWWTQGETPGTTGQWGVWSDQGACGGGSGQEPDPGTGDPSGFVVSEAQFNRMFPNRNPFYTYDGLVAALSAYPGFAKTGDDTVKRREAAAFLANVSHETGGLVYIVEQNTANYPHYCDASQPYGCPAGQAAYYGRGPIQLSWNFNYKAAGDALGINLLANPYLVERDPAVAMKTALWYWNTQNGPGTMTAHAAMVDGAGFGETIRSINGALECNGGNPAQVQSRVDKYQAFTQLLGVTPGANLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQV8</accession>
    <name>A0A0F4IQV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001340">
        <property type="protein sequence ID" value="KJY23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952050.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001340.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23878">
        <property type="protein sequence ID" value="KJY23878"/>
        <property type="gene ID" value="VR44_36975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4779"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18287" checksum="47C555A1549FD6AC" modified="2015-06-24" version="1">MSNEEFRAAMSRLAAGVCLITAHEPPLTAGGPRGEDVGMTATAFMSVSLEPPLVLVSVREGSRMDDLLAEQPLWAVSLLAESQLQVASRFSMKGRISDRLLFADIPYERGAASGAPLISGALATLECRTRSRVPAGDHTLVIGHVLTASFPSPDARPLTYFRGRYRHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR62</accession>
    <name>A0A0F4IR62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">VR44_35135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001215">
        <property type="protein sequence ID" value="KJY24510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951705.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001215.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene685"/>
    <dbReference type="EnsemblBacteria" id="KJY24510">
        <property type="protein sequence ID" value="KJY24510"/>
        <property type="gene ID" value="VR44_35135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4105"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18693" checksum="C6FE3F02D04AC983" modified="2015-06-24" version="1">MSTTQSDRLRGLLEPLVAAKGLDLEEIELSKAGRRRMLRIVVDSDEGVELDACAELSREVSDALDASDVMGEDEYVLEVSSPGADRPLSEHRHYVRAIGRLVKFQLSAEGEKGAGELVARILGVDDEGMDLEVPGVKGRKATARRVAFTDIAKARVEIEFNRKDKKEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRD1</accession>
    <name>A0A0F4IRD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001308">
        <property type="protein sequence ID" value="KJY24028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951966.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001308.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24028">
        <property type="protein sequence ID" value="KJY24028"/>
        <property type="gene ID" value="VR44_36530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6295" checksum="B15DA870BF5947F7" modified="2015-06-24" version="1">MAIASSRPASAGAVDVLLGGQRDGADEFQQLGDGHPRAHGVCLSGARKEGVTGIGDHVVAGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRF6</accession>
    <name>A0A0F4IRF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001303">
        <property type="protein sequence ID" value="KJY24053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24053">
        <property type="protein sequence ID" value="KJY24053"/>
        <property type="gene ID" value="VR44_36445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="29851" checksum="788BC2553EC0351B" modified="2015-06-24" version="1" fragment="single">MSLSPSRTFPPEIAESEALVALVERGREQGHINGDDVRQAFEAGRIPVDQWKRVLRSLNQVLDEEGVALHVSAAPATKAPAKKPRKAAAAPARTVTKKAAAAPRPIGARKASVAAAPAAAAAISAPSAAAAEEVSAEAAAEPKKRTVKKTAAKKATATKKTAAKKTTAKDADDAENPVVEGEDWAVEDLADETEEEAPKAGGQGFVLSDEDEDDAPAQTVMVAGATADPVKDYLKLIGKVPLLNAEQEVELAKRIEAGLFSEYKLEEEEDHKPAFKRELEILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRG3</accession>
    <name>A0A0F4IRG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001199">
        <property type="protein sequence ID" value="KJY24582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24582">
        <property type="protein sequence ID" value="KJY24582"/>
        <property type="gene ID" value="VR44_34930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4062"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11237" checksum="A071361195D6341A" modified="2015-06-24" version="1" fragment="single">PARSTAPAPPKQSSAPAPAPAPALSLRPTSVREFCANGEWPGTLVVRNSGGGNLKWSIGTLPAGVTAGPDSGSLDAGASQVITLGGRTEQQPAGGRFTIGLSSNGGSGQVTVTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISP5</accession>
    <name>A0A0F4ISP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_35230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001220">
        <property type="protein sequence ID" value="KJY24483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24483">
        <property type="protein sequence ID" value="KJY24483"/>
        <property type="gene ID" value="VR44_35230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4127"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="171"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY24483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="35487" checksum="9D00B0676610DEB2" modified="2015-06-24" version="1" fragment="single">LAVGAVLVLGALTAGAAGVRMDYGQGGAGGERTAATRTAEEIARSMPAGVSDPATVFVKARDGRPMTAERVAGLAGALARVPGVGQVTPAVLSADRGAARLDLLLTAEPGGQQARDLVSGPVRETVRAHVPAGTEAHVGGTAAVFADIAVAVGEDLEVVFPVAAVLIALILLVLLRSLLAPVVLMVAVGLGFTATLGAATLVFQHALGRPGVDFTLPLVLFLFVVALGTDYNILVADRIREEMERPGPARAAVGRAVRHTAPAVATAGLVLAASFGSLAVSPQPGLQQTGFATAVGILLSAFVLSVVLVPALAALLGRSLWWPVRPRAKTAADGERPAAGAERAEPGRVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT52</accession>
    <name>A0A0F4IT52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_33190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001111">
        <property type="protein sequence ID" value="KJY25185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951346.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25185">
        <property type="protein sequence ID" value="KJY25185"/>
        <property type="gene ID" value="VR44_33190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3512"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469778" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="11">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY25185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="14010" checksum="5F5A50EB69881817" modified="2015-06-24" version="1">MSASQPAARRTVLKGAAALAGAVGAGAALSACSTEGGSGAGGPAVPKEPVELGAAAEVPVGGAKLFREQKIVVSCPAEGQYKAFSAQCTHAGCVLDKIDKGEGNCPCHGSRFDVTTGKVLRGPASDPLPSVPVKAENGKLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW9</accession>
    <name>A0A0F4ITW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001121">
        <property type="protein sequence ID" value="KJY25099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951394.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001121.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5146"/>
    <dbReference type="EnsemblBacteria" id="KJY25099">
        <property type="protein sequence ID" value="KJY25099"/>
        <property type="gene ID" value="VR44_33425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3564"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="16897" checksum="B028A7B582A7FC12" modified="2015-06-24" version="1" fragment="single">MVVDDHPMWRDAVARDLAAAGFDVVATAGDGPEAVRRARAVAPRVLVLDLNLPGMPGVQVCKELVGADPALRVLVLSASGEHADVLEAVKSGATGYLMKSAGAQELIDAVRRTAVGDPVFTPGLAGLVLGEYRRLATDPAPAAADEPKAPQLTDRETEVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUI9</accession>
    <name>A0A0F4IUI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AurF domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001243">
        <property type="protein sequence ID" value="KJY24351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951795.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24351">
        <property type="protein sequence ID" value="KJY24351"/>
        <property type="gene ID" value="VR44_35630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4246"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="35050" checksum="2CDB3C69BD4E398B" modified="2015-06-24" version="1">MGVSAPLPVNDRFLEVLERLSHRSIEEYYNPYQQFDWPEKLDEGRMWMTPELLTVYGTPFYDELGEETLQRLSKWESINFYSLNVHGIRELLIEVVGRIHMPGFEVPSDFFHHFIGEENEHMWFFAEFCRRYGDKIYGSTALRADSAWEPEVENFLVFSRILFFEELVDHYNTRMARDESLCHTIREVNRIHHQDESRHIAFGRELVSLLFTRMKEAVPAARVAEVEAYLKRYVVYSINSLYNPHVYRDAGIADPIGLRNALVADERRRPHERKAIRKPLGFFLKTGIFTDDVLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV17</accession>
    <name>A0A0F4IV17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001215">
        <property type="protein sequence ID" value="KJY24511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951706.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001215.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24511">
        <property type="protein sequence ID" value="KJY24511"/>
        <property type="gene ID" value="VR44_35140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4106"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470167" evidence="2">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="18601" checksum="1EC4F6044ACA4DFB" modified="2015-06-24" version="1">MPWTLPSRPSPSRRSVLAGAAAAAAGSALVTGCSGGGGPAASDDAISLERRMREGAVRDSGRLLERYDATAAVHPDLTERLTPLREAVAAHVRALALTTPKPGPTPSRTASPSGSPSPSAPAAGRAEVPAKPTEALSALADAERSLSEARTIALAGAPGELARLLASVAACGAVHAYLLTSNPGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVL2</accession>
    <name>A0A0F4IVL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001065">
        <property type="protein sequence ID" value="KJY25498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951189.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25498">
        <property type="protein sequence ID" value="KJY25498"/>
        <property type="gene ID" value="VR44_32330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3267"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="34049" checksum="9F83D61DFA39A427" modified="2015-06-24" version="1">MTLHALHVRDLRPDDPADAEAVVRVRQAALPFMVTTVDGVAFTLGSAHPDARLRLLVAENADGRVVGTAEVGLAHDSPRPGQSYANVYVDPAARARGAGTALLRTAEEHLVAQGAVDAYTWVLDEPANRAFAERHGYRPSRSSNFLRLDLAEATLPPLPRELPAGVELRPASAFAADPRPLFEADAEATADEPGDVPASLDDYQGWLDGVWHDPTLDHGLTSVVLVGGEVAAFSAARTDGRTRYLSGMTGTRRAFRGRGLAKLAKTDSLRRARAAGYTEAFTGNDAGNGPMLAINKWFGYEICATETRFTKRLGGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW66</accession>
    <name>A0A0F4IW66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001014">
        <property type="protein sequence ID" value="KJY25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951002.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25884">
        <property type="protein sequence ID" value="KJY25884"/>
        <property type="gene ID" value="VR44_31335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2756"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20279" checksum="17303F39DC91BD1B" modified="2015-06-24" version="1">MTTSDLTLDSATALVLIDLQQGILALPTARPSGEVLARGIALAEAFRAHKLPVVLVNVAWSPDGGDLPSTDVDRPGPASAPPAAFSEIPAELAALGDITVTKRHWGAFTGTELDLQLRRRGVHRIVLAGISTSVGVESTARTAWEHSYGLVFAEDATADLDADSHAHTFGKIFPRIGRVSSTAEIIAALDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWJ9</accession>
    <name>A0A0F4IWJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001129">
        <property type="protein sequence ID" value="KJY25046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951426.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001129.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25046">
        <property type="protein sequence ID" value="KJY25046"/>
        <property type="gene ID" value="VR44_33610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3629"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34556" checksum="27587BE025F6EC2E" modified="2015-06-24" version="1">MENARLDEALRTLGIGPAASRVYLALLERAPAPLAEIGRAAGLEGAAFATAYGELVDAGLAGAAGEGTDVGAPVPPAAGLEVLARHRAAELEASRITVGGAFETFRRRRLTAHGDNLVEVVTGDAVGPRLRQAWASAREQIRQLESPPYFPQTEALDDALATLARGVTQRVVYSKASLETPGRLETAIEPCIEAGEQARVAPTVPVKLLIIDEAYALVSLSIRDSDVHHTTLVVQPCGLLSALVALFEQTWQQALPFHGRTTRPAGLAPADRRLRGAGDEVIARELGISRRTFFRRLQILMARLGAENRFQMALQAQRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXT0</accession>
    <name>A0A0F4IXT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">pgk</name>
        <name evidence="12" type="ORF">VR44_30455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="JZWV01000960">
        <property type="protein sequence ID" value="KJY26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950844.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26273">
        <property type="protein sequence ID" value="KJY26273"/>
        <property type="gene ID" value="VR44_30455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2505"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="360"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="42353" checksum="691592F0FF464B76" modified="2015-06-24" version="1">MKTIDELLADGVAGKRVFVRADLNVPLKEGVITDDGRIRAVQPTIAKLAEAGARVVVASHLGRPKGTGTEPDFSLAPAAKRLGELLGAEVAFATDTVGSSAKETVAALADGQVAVIENLRFNAGETSKDEAERVAFARELAELADLYVGDGFGAVHRKHASVFDLPKLLPHAAGYLIATEVGVLKKLTAEVKRPYVVVLGGAKVSDKLAVIDELLGKADRILIGGGMAYTFLYAKGYEVGISLLQKDQVDTVKEYMARAEKNGVELVVPVDILASADFPDIKGGTPADFETVDADKIPADKEGLDIGPRTRELYASKIADAETVFWNGPVGVFEHPDYANGTRAIAQALVDSRAFTVVGGGDSAAAVRILGFDENAFGHISTGGGASLEYLEGKTLPGLAALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY40</accession>
    <name>A0A0F4IY40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_28820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000884">
        <property type="protein sequence ID" value="KJY26935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950547.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000884.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26935">
        <property type="protein sequence ID" value="KJY26935"/>
        <property type="gene ID" value="VR44_28820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2104"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="35062" checksum="8C1BD88315EBD34B" modified="2015-06-24" version="1" fragment="single">PDPLRHVFLSDSGSVAVEVAVKMCLQYWRSLGRPEKRRLLTWRGGYHGDTFQTMAVCDPDGGMHSAWTGLLPDQVFADRPPAGFDAGVDEAYARHLADLVERHAHELAAVIVEPVVQGTGGMRFHSPGYLRLLREIADAHDVLLIFDEVATGFGRTGELFAADHARVSPDVMCLGKSLTGGYLSMAATLCTARIADGISRGEPPVLAHGPTFMGNPLAAAVANASLELLVRNDWRTQVKRIETRLTAALEPARALPGVLDVRVLGAIGVVQLDHDVDVAAASRAAMRAGVWLRPYRDMVYSMPPFVTGDEDLARIARGVLAAAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYP6</accession>
    <name>A0A0F4IYP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950618.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000904.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26784">
        <property type="protein sequence ID" value="KJY26784"/>
        <property type="gene ID" value="VR44_29225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2190"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469961" evidence="2">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="83"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="21862" checksum="2727544DE110C3CD" modified="2015-06-24" version="1">MNSLKIRRTAIAVAAAALLPFSLAACSDSGSDAKTAPTAAADDQAKTGESTPAGDSMTGGRPFGPACAGVPKDGAGSFDGMAKDPVATAASNNPALSTLVAAVKKAGLVDTLNNAKDITVFAPTNDAFAKIPKADLDKVLADKATLTKILTYHVVGQKLTPEQMENGSFETLQKGAVTTAGSGESYKVNATSNVVCGNVKTANANVYIVDTVLMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYT8</accession>
    <name>A0A0F4IYT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000915">
        <property type="protein sequence ID" value="KJY26633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950689.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000915.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26633">
        <property type="protein sequence ID" value="KJY26633"/>
        <property type="gene ID" value="VR44_29595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2298"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16905" checksum="6CA9EEB1B84A45CE" modified="2015-06-24" version="1">MSQAKESIEVDVPVTTAYNQWTQFESFPEFMEGVERIEQRGDTLTHWVTNVAGIRREFDAEIIEQIPDTKVAWVTVGGQSEQSGLVTFRPIDRSLTEVTLVMDFDPEGLAESVGDKLGFVDRQVKGDLKRFKYFIENRGIETGAWRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0W4</accession>
    <name>A0A0F4J0W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000926">
        <property type="protein sequence ID" value="KJY26551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950719.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000926.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26551">
        <property type="protein sequence ID" value="KJY26551"/>
        <property type="gene ID" value="VR44_29760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2332"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="29244" checksum="A8E2A89EDC069825" modified="2015-06-24" version="1">MGSHPQQPPMPVPATAAGREGLEALLRTPRRAVIALDFDGTLADIVPDPDQARAHADAVPALAALAPEVAAVAVVTGRPAGVAVRYGGFAGVPGLEHLVVLGHYGAERWDAVTGVVHAPAEHPGVAAVRAELPGFLDAIGAWRGTWIEEKGQALAVHTRRAEDPEAAFEALREPLAELAARHGLIVEPGRAVLELRPPGMDKGVALTEFLQERDAGPVLYAGDDLGDLAAYSAVEKRRAEGLPGLLVCSGSAEVPELAARADLVLPGPGAVAAFLAQLAGALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1H0</accession>
    <name>A0A0F4J1H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000805">
        <property type="protein sequence ID" value="KJY27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950212.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000805.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27714">
        <property type="protein sequence ID" value="KJY27714"/>
        <property type="gene ID" value="VR44_26980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1558"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470042" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13456" checksum="A3E675585747E2AC" modified="2015-06-24" version="1">MRRLAAPVLTLAGAVAAFAYVGAVDPNEPGHYPVCPLFRLTGVLCPGCGGLRSAHAFARGDLVTALGDNAMAVAGYLVFAAFTALWLGRAFRGGPVPRIALGPAWWWAIGTLALAFTIVRNLPIGSVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Q4</accession>
    <name>A0A0F4J3Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000688">
        <property type="protein sequence ID" value="KJY28962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949667.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000688.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28962">
        <property type="protein sequence ID" value="KJY28962"/>
        <property type="gene ID" value="VR44_24060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470705" evidence="2">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6686" checksum="4ED9448A9817471C" modified="2015-06-24" version="1">MFATRIAKTVAAAVIAVGALGVAHSFTTGEAAAPHHVSADGVGTGTTIPLNQPTGHQSHSTDVTWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J400</accession>
    <name>A0A0F4J400_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000720">
        <property type="protein sequence ID" value="KJY28539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949857.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000720.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a0f4j400">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28539">
        <property type="protein sequence ID" value="KJY28539"/>
        <property type="gene ID" value="VR44_25080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1106"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="5">
        <location>
            <begin position="348"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="475" mass="49923" checksum="ADE7DB6858E92C6B" modified="2015-06-24" version="1">MTVVVTSAGKIRGTSRDQIACFRGIPFAAPPEGPLRFQPPAPPSPWDGVRDTLAFGAAPPQLAPAPGAPAIWRPGDGLDCLTVNVWTPDPGAAGLPVMVWIYGGVWKYGSASMPQYDATALAAAGVVVVTFNYRVGFEGFGHLSGFPDNRGLRDQIAALQWVQDNIAAFGGDNANVTVFGQSAGAASAVLLASAPAARGLFRRVIAQSIPAGARTRTEAHAATTAIARAAGLPATWDALASLPPEALLAVQDAPLRGPEDGFTAFGPVVDDDLVTGQPWTAFEAGAGGEVDLICGFTHEEYRGQGPVPAAQDIDLGQVTEAVGLGKDAAAAYREGYPGLSDDALFTGVLSDALVRMPTTRVAQAHTRAGGRTWLYDFTWQGHALGAAHGIDVPFTFGNPNTRYAALFLGSPPPADFADLSERLRTAWTSFARTGDPGWPRFTPDQPTTRIWNLPPTDTAYPLEASRQIWERTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J433</accession>
    <name>A0A0F4J433_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949903.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000730.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28458">
        <property type="protein sequence ID" value="KJY28458"/>
        <property type="gene ID" value="VR44_25350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1167"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="20522" checksum="389E97823949B5FA" modified="2015-06-24" version="1">MRQNPERRAALLDAAIEVLAREGSRGLTLRAVDKEAGVPTGTASNYFAHRGQLLSQILRRTRERLAPDPAETAGPLDTVELLRRLLGRLRREPSIQTAVLELRLEATRRPELQEELSAFLAAELEPNIAGHLEAGLPGDRQGVELLYFAMQGLIVDDLTVPALLDAHPVEPLLGVLVERLLPARPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4A1</accession>
    <name>A0A0F4J4A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949829.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28644">
        <property type="protein sequence ID" value="KJY28644"/>
        <property type="gene ID" value="VR44_24940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.988"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="523" mass="55353" checksum="985875753E30E9C5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4F3</accession>
    <name>A0A0F4J4F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949800.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000708.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28699">
        <property type="protein sequence ID" value="KJY28699"/>
        <property type="gene ID" value="VR44_24785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.958"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="32611" checksum="3A31F99966A69ED0" modified="2015-06-24" version="1">MPATAETVRAFRDRLGLPGLVDVHTHFMPDRVMRKVWDYFDAAGPLTGTEWPITYRHEEEQRVGLLREFGVRAFTSMLYPHKPAMAAWLNAWAEEFAARTPDCLHTATFFPEEDAAAYVARAVESGARVFKAHLQVGGYDPNDALLEPVWGLLAEARIPVVVHCGSGPAPAEYTGPGPVARLLARHPRLPLIVAHMGMPEYTDFLDLADRYPEVRLDTTMAFTDFSERFTGFPPGDLGRLAGLGDRILLGTDFPNIPYPYEHQLQALERLGLGDDWLRAVCHDNAARLFSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4I9</accession>
    <name>A0A0F4J4I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_23340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949532.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene118"/>
    <dbReference type="EnsemblBacteria" id="KJY29272">
        <property type="protein sequence ID" value="KJY29272"/>
        <property type="gene ID" value="VR44_23340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.608"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY29272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32724" checksum="107239504935D889" modified="2015-06-24" version="1">MTASAESAESPARSPLHEPVIAWFDEHARDLPWRRPEAGPWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPRRALRLHGAAAAITERHGGDVPRDHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVLARTSTGVEYPPNATTAAERRLARALLPEDEATAARWAAASMELGALVCTAKSPDCVRCPVAGLCAWRLAGKPAHDGPPRRGQTYAGTDRQVRGRLLAVLREATGPVTQAQLDAVWNEPVQRARALDGLVSDGLVEPLARGMYRLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6S0</accession>
    <name>A0A0F4J6S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_24975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949841.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000714.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28621">
        <property type="protein sequence ID" value="KJY28621"/>
        <property type="gene ID" value="VR44_24975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1083"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="348" mass="35737" checksum="6DDA8BE039DBB9B4" modified="2015-06-24" version="1">MRKAARPRTLRGPAATSLRVEPRALLGGLLLVAATLVLAVVLIGTGDFEIAPGDVVRTLLGDGTPADDFIVNDLRLPRVLVAILVGAALGMSGAVFQSVSRNPLGSPDLLGFGYGSAVGALVVITVFKGGATEVALGAVVGGVLTGAVVYLLAYKKGIHGYRLVLVGIGASAVLVAVIQYLIAKAQLIEATRAMVWLTGSLAGRDWAQVWPLLAACAVLFPLVLGQGRALRVIEMGDDAAYALGVPVERTRMLLMLAAVLLTTAAAAAAGPISFVALAAPQLARRLTRSPGSNLLTGALMGTVLLLASDLASQRAFGADQLPVGVVTGLVGGVYLLWLLVMERRAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J837</accession>
    <name>A0A0F4J837_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949603.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29111">
        <property type="protein sequence ID" value="KJY29111"/>
        <property type="gene ID" value="VR44_23720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.692"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17809" checksum="1D2E69DE0474DEB5" modified="2015-06-24" version="1">MTLMDVLVDFARTGRIGPLHCGMPLIEAEDLLGPGRPHPAHIMKGPDIDGYPYSWSGLRLVVTQRAVSGIWISLWPGSTAKLPPLVLPDSESFEATVLREELVTALDTAGCDHGVNPVLTFGEQSSILTQPAEVCAVFSLPGRDHHVPHHDRHYLDVMHKHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8G3</accession>
    <name>A0A0F4J8G3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">VR44_23410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949547.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5185"/>
    <dbReference type="EnsemblBacteria" id="KJY29246">
        <property type="protein sequence ID" value="KJY29246"/>
        <property type="gene ID" value="VR44_23410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.624"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="188"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY29246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="38238" checksum="346866FF2702C5AC" modified="2015-06-24" version="1">MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETRLVPERGYELGLIPAVPLPRKPTPELITVPGRLRGTIKAAEEILVRTKADVVVGFGGYVALPGYLAAKRLGVPIIVHEANARPGLANKIGSRYAHAVAVSTPDSKLRGARYVGIPLRRSISTLDRAAVRPEARAAFGLDPNLPTLLVSGGSQGARRLNETIQQAAPTLQRSGIQILHAVGPKNELPRVDNMPGMPPYVPVPYVDRMDLAYAAADMMLCRAGAMTVAELAAVGLPAAYVPLPIGNGEQRLNAQPVVKAGGGLLVDDAELTPDWVLGQVLPVLSDPHRLYEMSRAAAEFGRRDADELLVGLVHEAIAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8K1</accession>
    <name>A0A0F4J8K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948961.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30515">
        <property type="protein sequence ID" value="KJY30515"/>
        <property type="gene ID" value="VR44_20240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8755"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="345" mass="35760" checksum="0EB7C4203211688D" modified="2015-06-24" version="1">MWPGQQQPPGGQQGPQDAQQNPYQQQPGQPNPYQQQPQPGFGQQQPGYGYPQAGGYQTPPPVQPWGQPAPAPSAPRTSGGSPFSTKTVAIVAASAVVVTAAATAAFVLTRDDKASNQANDKPAAASSAPVTPAAPPAPSSNPRGGGDTKPVIPGWKVVMNPKHGTAFDVPPEWNVASSGVISGFEDAKKGDGSPLVTFSAPAFLKEDWCKVDSNKDGKEESTGLAGTGTKGGQGAKDTAGAAHSEAGTWVFAAFSQKLPEDRVKISESKEFTTLSGLKGHYATATVSDIPKENKCTTDGKSIAFSFRNSKGDFASWVLWSAAGVPGEVDQATEEKIMSSVRLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9N1</accession>
    <name>A0A0F4J9N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000624">
        <property type="protein sequence ID" value="KJY29686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949345.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene473"/>
    <dbReference type="EnsemblBacteria" id="KJY29686">
        <property type="protein sequence ID" value="KJY29686"/>
        <property type="gene ID" value="VR44_22305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.348"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="36863" checksum="F6AF6721E32C5237" modified="2015-06-24" version="1">MTEAILLVGGQGTRLRPVTVNTPKPMVPAAGVPFLAHQIARAAAAGVTHIVMATCYLAEVFEPYFGDGSDFGISLEYVVEDEPLGTGGAIRNAAQRLTGGPDSPVLVFNGDILTGLDIAGLVESHQAADADVSLHLVRVEDPRAFGLVPTDADGRVLAFTEKPETPEEIITDQINAGCYVFRRSVIDSIPAGRPVSVERETFPGLLASGAKLHGVTEDTYWLDLGKPESFVQASADLVRGIVSSPAVPGPRGEALVLPGAQVAEGAKLTGGTVVGAGARIESGAVVQGSIVLDGAILGADTVVNASLIGAGASVGSRTVVTGAVIGDGAVVGADNELRAGVRVWCEAELPDAAVRFSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA56</accession>
    <name>A0A0F4JA56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000506">
        <property type="protein sequence ID" value="KJY31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31252">
        <property type="protein sequence ID" value="KJY31252"/>
        <property type="gene ID" value="VR44_18505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470522" evidence="2">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17919" checksum="F0A8103408A456EC" modified="2015-06-24" version="1" fragment="single">GSVKLAVMAAVLLLFGWLVWASKRCATSADLKGIRVRRFTGSRRLAWEDIQEIRAARNPSAGVGQNQPTLISYAYDGEGRRVQLMYVDDNHVDVEREIAALRAAWEELRGPDWAPDPRARERMERQAVREGRVMKATFWGCGIFLVLFVIAMIVIVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAE3</accession>
    <name>A0A0F4JAE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30723">
        <property type="protein sequence ID" value="KJY30723"/>
        <property type="gene ID" value="VR44_19670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8548"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="14288" checksum="DD3ECF5F1095C5AC" modified="2015-06-24" version="1">MSDELWSLIEPLLPEPAPKRAEGRPRVPDRQALCGILFVLHTGIQWEYLPQELGFGSGMTCWRRLAAWNEAGVWDQLHLMLLKKLRVAKKLDWSRAVIDSSHVRAARRGPKAVPARSTVHGRAASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAX9</accession>
    <name>A0A0F4JAX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948770.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30939">
        <property type="protein sequence ID" value="KJY30939"/>
        <property type="gene ID" value="VR44_19190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8444"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="212"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="45584" checksum="7A24269651441571" modified="2015-06-24" version="1">MTVFVVIVAVVAVLALLGMVHRWLWVRLVRDTTRAGGPARRAGTVLAFALPLLSLAALLAGRAGAPFWLQRLVAWPGFMWLAVLLYLTLAMLVAEPVRRLWLRRIARGTPAGPGPEPAGVTAGPPGGPADSAARPDEPAPQTGPGSVAPATAESRSAGGATAPATADPVPAGAPGARPPAAVGAGTYGVLRGPRVKRVQVPLARLPRAAHGFRIAVVSDVHLGPVLGRAHTQRIVDTVNRTQPDLIAVVGDLVDGNVHDLGPAAEPLRQLRSRHGSFFVTGNHEYFSGAQQWVDHVRELGLTPLENARRELPHFDLAGVNDVQGEQEGKGPDFQAALGDRDRSRASVLLAHQPIVIHDAVRHGVDLQLSGHTHGGQLWPGNYLAELANPTVAGLERYGDTQLYVSRGAGAWGPPVRVGAPSDITVVELASYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB55</accession>
    <name>A0A0F4JB55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000481">
        <property type="protein sequence ID" value="KJY31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948506.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000481.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31597">
        <property type="protein sequence ID" value="KJY31597"/>
        <property type="gene ID" value="VR44_17820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8107"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="22537" checksum="983CCF16A809A2F6" modified="2015-06-24" version="1">MPRQVDHEERRRLIAGAVCRLADESGLEGVTLRDVAGRAGVSMGAVQRCFRTKEEMLLFTLGHIGELIAERVRARLVRSPAQSAASALGHAATEVALLREEHRAEARVWLAFVAQAAVSAPLAESLRTNYAALEAMFARLLAEAAADGPAGVPPAPRQQARTLLALADGLTTHVLIGHLTAHQAQEVLHGHLAGLWGHEGAGGAGGAGEDPPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB71</accession>
    <name>A0A0F4JB71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949091.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30236">
        <property type="protein sequence ID" value="KJY30236"/>
        <property type="gene ID" value="VR44_20950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8920"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="9306" checksum="A23E68210334257B" modified="2015-06-24" version="1">MGLLTALVTAPLLPVRVALWVAERVAEEAEAVYYDPGPVRAALAELEHRLVEGEIDEETFDREEDALLDRLEEIEEFRRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBR9</accession>
    <name>A0A0F4JBR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948671.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31188">
        <property type="protein sequence ID" value="KJY31188"/>
        <property type="gene ID" value="VR44_18695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8349"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="4"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="39990" checksum="6D0297FA1E5ABE4F" modified="2015-06-24" version="1">MEEVLITGLGAVSHLGSGADALWHGLMRARSRPERAADPHARMDVPLMYSVPGTPDPDGPAEGPSTAARFAVEAARQALADSALGEVAPERVAVVIGTGMGDATLHERWRAEGHSPDGEWAPVFSVASSLGEWLGAEGPNTSISNACAASGFGISAAAELIRTGAADVVLAGGAEAYSRVALACFNRLGAVDPERCRPFDANRRGTVFGEGAGVLVLESAAHAAARRAPRVYARLAGEGWSCDAHHATAPEPGGTQIVRAMREALERAGAGPGEIGCVVPHGTGTELNDAVESRALHEVLGAAAGRTPLYSLKALVGHTGGAAASLAAVAAALVLHHRTVPPNRPVEERDPDCDVLLPVEPAPLRGSFALVNAYAFGGNNVSLVLQEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCG0</accession>
    <name>A0A0F4JCG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32032">
        <property type="protein sequence ID" value="KJY32032"/>
        <property type="gene ID" value="VR44_16905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7818"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="16490" checksum="23F23C9F77E1A533" modified="2015-06-24" version="1">MNTEAIPNAVPAAAASSTLRSTARRIRPAAGTSTATTTAVTVSSRLRSPPARAWCPRPSPPVRASSPARPTVASRAPRQAAAPARRPTNAAAIGRAKTMVSAPSGWTRLSGPYASATTCSRAPRQFSETAAHQPGLRSGARARRSAELAATCSWRIAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEM0</accession>
    <name>A0A0F4JEM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000431">
        <property type="protein sequence ID" value="KJY32208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32208">
        <property type="protein sequence ID" value="KJY32208"/>
        <property type="gene ID" value="VR44_16395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7675"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="51205" checksum="253D9F4DCD1D0E8E" modified="2015-06-24" version="1" fragment="single">PAPAPAPAPAPDAVPAGSPETASYQPSLAQQRMLFVDLMQEDSNQHNVTLAVDIAGRVDPAAMRAAFTDAQRRHSGLRTVFHQKGGRFETEILAEPGVELTVLDTAHAGPASGTLRPLAGDEDVREWVRELGAPPQRCFAEPPVRATLVLGPERSLLVVTVHHAVTDATSMGVMVEDLAQDYHRRRAGDDTPARAGRHQFHDVLAELERAERNDTTGSSAYWRAQLEGAPDLVPLPTDRPRPEVRAGAGAMWGCDLDPALASRIRGLSAELNTTPFSTMLTAYAVLLRHHSGAEDMAIATPVTSRSTEAAQRVFGLMLNTLVLRVKAGHDASFTSLARSVGAVVLDGIRHSAFPFDRLVAELNPKRHPGRTPLFSVMFAMPVDFPLPDFDGRPARPVELPGLGAKFDLTLYVTPAADGGLHLDWEYDPALFDEGTVRRWGADYTRLLEAVVADPGSPPSLPAPEAPADDTATTEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF05</accession>
    <name>A0A0F4JF05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948173.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32394">
        <property type="protein sequence ID" value="KJY32394"/>
        <property type="gene ID" value="VR44_16040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7629"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16395" checksum="A58AD99A3CF5848F" modified="2015-06-24" version="1">MGPERGAVGHLDDDLPGRDGDPQAGEAFPVPQRAGDELAHHRQHIVDQDRCPAVFGQDSAGGLPRLRTVHLGREALDVGAPRSAAYPGEVLGQGLYARLEGGRSPPGCGLRGRNRDRPKTRGRLMPPRTLRERGATSGRNGAATDFHEFVTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFD1</accession>
    <name>A0A0F4JFD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000410">
        <property type="protein sequence ID" value="KJY32463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32463">
        <property type="protein sequence ID" value="KJY32463"/>
        <property type="gene ID" value="VR44_15900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7589"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="7763" checksum="A495DC8EC0CE17B7" modified="2015-06-24" version="1" fragment="single">PERFAEIARPFLAAVVAVADEDGTGATPAAATRVLRVLGTPPPLAAHVAAALAGPDGHISEDATLKAFAAYCGVDPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFJ6</accession>
    <name>A0A0F4JFJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000469">
        <property type="protein sequence ID" value="KJY31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31761">
        <property type="protein sequence ID" value="KJY31761"/>
        <property type="gene ID" value="VR44_17545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8070"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="35" mass="4320" checksum="98CD3E54473B4F86" modified="2015-06-24" version="1" fragment="single">MRGFVVLPKRWIVERFFAHLTRSRRLVRDFERSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFM2</accession>
    <name>A0A0F4JFM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDPG_MGDP_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000467">
        <property type="protein sequence ID" value="KJY31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31786">
        <property type="protein sequence ID" value="KJY31786"/>
        <property type="gene ID" value="VR44_17495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8061"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="3">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="25266" checksum="8B13D310938F4C8C" modified="2015-06-24" version="1" fragment="single">VVLLSTDFVTADLTKAAANAFLSTKISFANLVDDVCQAAGADSKTVATAMGLDPRIGPFGLTAGLGWGGSCLSKDIRALADRAQALGQSGAATFFSHVDYTNTARRDLAVTHAESVLPGGLEGSVVALWGASYKPNVGDISDSPALDIALRMHRAGAEVRVHDPSVNDLVRRHHPELTVVDAPAEALVGAGVLIVATDWPRYTALDPASFADSTTRTVIDARRCLDHQTLGAFRHHTAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG76</accession>
    <name>A0A0F4JG76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000370">
        <property type="protein sequence ID" value="KJY33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947861.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000370.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33210">
        <property type="protein sequence ID" value="KJY33210"/>
        <property type="gene ID" value="VR44_14325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7214"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="27624" checksum="3DE393FB8D5370A9" modified="2015-06-24" version="1">MVTSDQRRRQLAREKYERQQKRRAEARRRSRQRLAIIGAASAAVIAALIGLIAGGVFDSKDKNDSAAEPSASPSLPEPKKSPSPAMAIDDKAKYTFDLKTSAGEIRFGMDASKTPQTVNSFKSLADKGFFDKTKCHRLVTSGIYVLQCGDPEGTGRGGPGYNIPDENLDSLGKPNEQGQVVYPAGTVAMANTGRPGTGGSQFFLVYKDSPLAPSYTPFGKIDAEGLKVLEEVAKAGTADGAQDGAPKTPVTIEKAAVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG95</accession>
    <name>A0A0F4JG95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">VR44_17065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000450">
        <property type="protein sequence ID" value="KJY31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948367.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000450.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7019"/>
    <dbReference type="EnsemblBacteria" id="KJY31971">
        <property type="protein sequence ID" value="KJY31971"/>
        <property type="gene ID" value="VR44_17065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7944"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="11804" checksum="0D51B85FCD33C3C6" modified="2015-06-24" version="1">MGRVSVAPIEIERTESAEETFAVPEPDVPWVTLVHNDPVNLMSYVTYVFQAYFGYPKDKATRLMLDVHNKGRAVVSSGTREEMERDVQAMHGYGLWATLSQDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGN9</accession>
    <name>A0A0F4JGN9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947771.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33502">
        <property type="protein sequence ID" value="KJY33502"/>
        <property type="gene ID" value="VR44_13835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7046"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16208" checksum="C7F0E7491F34DE52" modified="2015-06-24" version="1">MIKQEQLAAMAGCAAYTEGGQRVGGVEYVLVDDTTGRPEWVRITDRASGLGGVFAPLRHAVLEQERLVLPYAVSLIERAPCAALDCGSVLTVAEEQRLFAHYGLTDVREEVNAEPGSGWSRMDRADTIREGTAGREARVSRLRPARPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHC3</accession>
    <name>A0A0F4JHC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000370">
        <property type="protein sequence ID" value="KJY33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947860.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000370.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33209">
        <property type="protein sequence ID" value="KJY33209"/>
        <property type="gene ID" value="VR44_14320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7213"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="24802" checksum="EF79EF457E6AB6B6" modified="2015-06-24" version="1">MLIAGFPAGAWGTNCYLVAPAAGEECVIIDPGHQAAQGVEETLRKHRLKPVAVVLTHGHIDHVASVVPVCGAHDVPAWIHPEDRYMMSDPEKALGRSIGMPLMGELTVGEPDDVRELSDGAALKLAGMEFSVAHAPGHTKGSVTFRMPEQADVPPVFFSGDLLFAGSIGRTDLPGGSHAEILQSLARVCLPLEDSTVVLSGHGPQTTIGRERATNPYLREVAAGLGNGTAAPRRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHE8</accession>
    <name>A0A0F4JHE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_16050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948175.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32396">
        <property type="protein sequence ID" value="KJY32396"/>
        <property type="gene ID" value="VR44_16050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7631"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="343"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="498" mass="54313" checksum="4DA928862744FD89" modified="2015-06-24" version="1">MPTAPCDPYRPVAHLRPPRNWINDPNGLVFHDGHYHVFYQYNPSGATHANMHWGHFRSPDLLTWEPLPIALSPAPGGVDADGCFSGNAVSDRDRLVAFYSANRWDRSPQHQPVTAAISRDGGRTFAPRGDLVIPGWPEDCTMYRDPYVWLDGERWRMLVGAALVDGRGAALLYESADLETWTYLGPFEARPQEPVGTTGLHTGEGWECPQYLPPQSGQPGVLIFSAWNSHDGDRCVTALIGEEHGNVFEAGTPVLVDHGPDCYAPALLRAPDGRWLLWGWSAEAREESWAVAGGWAGALTLPREISISAEGTLRQRPAAELHSLRGEQALHAKGVSHGPQPVELGGVGHVFDLTAQLETTGAASLRLLTNPDATEYLEIRLDATAGELVVDRDHASLGGRARGGSYRMPCPTGQPVELRLVVDHSIAEVFLTTTGQVLTLRFYPTGEGPWRLEARTAPDTHLSYTVEAWQLLPLTVKEPSADTDLHGQVPLTESSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHV4</accession>
    <name>A0A0F4JHV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947808.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33399">
        <property type="protein sequence ID" value="KJY33399"/>
        <property type="gene ID" value="VR44_14015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7106"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="29033" checksum="BF8610185CD61033" modified="2015-06-24" version="1">MPAKPLDPSSPRALLGAELRVARERRDMSQAALGEKLFVSGSYIGQMENGTRRITLELATAIDQVLGTDGFFTRNCGKQGKSKYPEHFVEAAEAEAEALTIREYAPLVIPGLLQTEAYAREIFHAYQPLAPGSVIDDLTEARLDRAKLLADPTTPLFWCVLDEAVIQRVVGSRAVMAEALQHIVGLIRARRIIVQVIPFSAGAHASLAGPLKLMSFEDAPPLAYVTGLGTGQLSDDPATVTQHTLTYDLLTASALSPNASLALIESAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIQ1</accession>
    <name>A0A0F4JIQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947729.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33648">
        <property type="protein sequence ID" value="KJY33648"/>
        <property type="gene ID" value="VR44_13610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6983"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8234" checksum="4756F438F9D72D8E" modified="2015-06-24" version="1">MSGRPDGERDPAQGLRTHAALLRERAERLRGACAALDWKGPQADAFRARVDELALRCTRAAEGLTRSAAEFDGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIV4</accession>
    <name>A0A0F4JIV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000344">
        <property type="protein sequence ID" value="KJY33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947705.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000344.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33703">
        <property type="protein sequence ID" value="KJY33703"/>
        <property type="gene ID" value="VR44_13455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6928"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9692" checksum="96B7482121AD6DC7" modified="2015-06-24" version="1">MSEQYEYVPHRLLRRRVRDIASGVEGVLMAVINENVSDTADYERWMELAYIRNASGREFTTAVANVQPVYDQPQTAGSRRDGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJF1</accession>
    <name>A0A0F4JJF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947400.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34452">
        <property type="protein sequence ID" value="KJY34452"/>
        <property type="gene ID" value="VR44_11820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6369"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12251" checksum="C90B156CEF38247B" modified="2015-06-24" version="1">MTSKERTGRNEDSRKPEPYVVRVSGEMDHDHAEQLSALLTAAVDETPEGADIIVDLRNSSFCDSSGLSVLLAARQQAQEARHQLVLAAPSHQLVRVLELTESADLFTLAPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL80</accession>
    <name>A0A0F4JL80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000343">
        <property type="protein sequence ID" value="KJY33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33726">
        <property type="protein sequence ID" value="KJY33726"/>
        <property type="gene ID" value="VR44_13440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6924"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="30289" checksum="BDE2EF4CEC5224F1" modified="2015-06-24" version="1">MLRTLADRGTVTATAEALHMTPSAVSQQLTNLARRLGVVLLEAQGRGVRLTDAAHLVLHHADAVFAQLERADAELAGYLSGEVGEVRVGAFSTAIPSLVVPAVAALKEQHPAVEVRIRETDAAESYDLLSTGAVDLALSLAAHSAGDDSRFTRIPLLVDPLDVALPPEHPLAQAPVIRLADLSSDRWIYGGSGPWSEITRSACEAAGFLPEQAHTASGWTAILAMVEAGMGVALVPRMVSARAAGVTLRVLTHDRPTRHVVAALRRGAESTPAVARVLTALRTTAGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL98</accession>
    <name>A0A0F4JL98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947258.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34950">
        <property type="protein sequence ID" value="KJY34950"/>
        <property type="gene ID" value="VR44_11055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6095"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="33247" checksum="82C39AC08245A3DB" modified="2015-06-24" version="1">MNSHVVIGFGPAGAATARLLVEQGRTVKVVTTSGRSPEPGIEHVALDARDSGRLTEAVRGAAAVYSCAAPPYHRWAAEWPALASSLCTAAEETGAVLVMLGNLYGYGPVDGPLTEDLPLAATGTKGRVRAAVWERARDLHQQGRIRAVEVRASDFFGPGVTDGGHLAARVLPPLLRGKPVSTLGDPDAPHSWTYLPDVARALVETAGDERAWGRAWHVPTGPALSVREMVDRLAAEAGTGPVAVRGVPPLVLGLGGLFSPLLRELKEIRYQFDRPFTVDSSAYETAFAAQPTPLDEQVKATVDWWRGRLATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM11</accession>
    <name>A0A0F4JM11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_10595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000235">
        <property type="protein sequence ID" value="KJY35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35235">
        <property type="protein sequence ID" value="KJY35235"/>
        <property type="gene ID" value="VR44_10595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5863"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="42044" checksum="36981F547641217E" modified="2015-06-24" version="1" fragment="single">MTLRDGDPRTVGGYRLEGRLGEGGMGVVYRARSLSGRQVAVKVIRPELAGDPAFRQRFRREVAAARQVSGAFTAPVVDADSDAAAPWLATLFVTGPSLAERVHAQGPLPAAEVWMLAAGLVEALRDIHRVGLVHRDLKPGNVLLAQDGPRVIDFGIARAVTGPGAEATALTGTGVMVGTPPFMAPEQFGRGEVGPAADVFALGSVLVHAATGHGPFNGDSFHAVAFQVVYEDPDLTGLPPQLRPLVESCLTKDPAARPTVPGLLTLLAAGPSAAGGPGAPGPAVPAAEYASDGVVEPGLPDGVVRPSTAVTVSPAAEGFFGPPLTVIAGPQPAPDGAGAPPVSGGPAPERDAGADPERERELGSRPRREAEAPRRGRRMRIAVAVAVVVALGTGGIAAWQGLRDEDKGGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM36</accession>
    <name>A0A0F4JM36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="6" type="ORF">VR44_10505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947153.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35260">
        <property type="protein sequence ID" value="KJY35260"/>
        <property type="gene ID" value="VR44_10505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5844"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8591" checksum="36C90C9A71B75137" modified="2015-06-24" version="1">MSAHCQLTGAKPGFGNNVSHSHRRTSRRFDPNIQSKRYWLPGEGRHVRLTLSAKAVKTVDAIGIEAAVARIRARGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMQ5</accession>
    <name>A0A0F4JMQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_09525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35647">
        <property type="protein sequence ID" value="KJY35647"/>
        <property type="gene ID" value="VR44_09525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5306"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="7"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="33133" checksum="8C421A691A2F8AB9" modified="2015-06-24" version="1">MTRTAFLFPGQGSECAGMGKELIAQRPDLADTYYRTADDLLGFPLSRLCVDGSPRDLEDPTVAQPAAFLTSMAVLEVLRGRGLEPDAVAGHSLGEYAALVAAGALEWTEALWLVRLRSELVATVGDRVGSATAAVIGLSRPDLTRLCAETRAATGQVVEVAGDNEPRQTVVSGQAEAVARVAEEARAAGARVEWLRTGGPFHSSLLGEAEAEFTETLIATEFRDPAVPLVSGVTGGWVTTAAEAVVALRGQLTSPVRWTGAVETLAASGTDRFVEVGPGRVLGGLVRRILPGARVHSTHTPERLARAVDDLSATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMV3</accession>
    <name>A0A0F4JMV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947191.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35154">
        <property type="protein sequence ID" value="KJY35154"/>
        <property type="gene ID" value="VR44_10705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5888"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="17947" checksum="C6A3528223BB0A31" modified="2015-06-24" version="1">MEAAAPNRTRQAPGTFTSFARFVLCGGGVGLASSFGVAALASWTPWVLANAAVTVASTLLATELHARFTFGAGGRATWRQHAQSAGSATAAYAVTCVAMLLLHHLAETPGAVVEQAVYLSASAFAGVARFAVLRLVVFARHRSNGAPATARTARPATAAVARPETLGDPAALCRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN25</accession>
    <name>A0A0F4JN25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947190.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35153">
        <property type="protein sequence ID" value="KJY35153"/>
        <property type="gene ID" value="VR44_10700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5887"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="44433" checksum="11CEA27048E32C64" modified="2015-06-24" version="1">MSEQPVLLPYADPAFVADPHPLYRQLREEGPVRRVVAAGALEAWLVTRYDDALAALSDARLSSDVRDASDARLLRQLPEAERESLLSNMLRSDPPDHTRLRRLVSQAFTARRVAAMRPRIQTLTDRLLDALAPAGRADLVADFALPLPVTVISELLGVPVDDRHDFQHWTDRLIRRGVRAPDPAVVDEAWRHMRAYVTGLIREKRAEPGDDLLSGLVTARDEEQRLSEDELVAMVFLLLAAGYITTVNLIGGGIAALLTHPGQLDLLRSDPALLPGAVEEFLRYDGPVSPGIARFAREDVEIAGVRVPRGATVLIGSAVADRDPARFPDPDRLDITRRDNAHLAFGHGIHYCLGAPLARLEGEIAIGTALRRLPGLALAVRPEEIDWRPGGLRGPESLPVTFVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNB8</accession>
    <name>A0A0F4JNB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947170.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35248">
        <property type="protein sequence ID" value="KJY35248"/>
        <property type="gene ID" value="VR44_10580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5860"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="22059" checksum="D707E03DA31F4A5A" modified="2015-06-24" version="1">MPVGGAGGPGDGAAEPGTVRPGGRTARVRAAVLEAAGDMLAEQGFHGLDLAEVARRAAVGKTTVYRRWGTVAGLVADLLTDMAEQSLPRSDTGSLEEDLLANARLVARTLSDPRQGPLFKAVIAAATCDARTAEALHRFYEVRVAEWAPCVQEAVERGELPGGTEASDVVRAVSAPLYYRLLTTDAPLDEAAARRAAGAAVAAARAGAFVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNN1</accession>
    <name>A0A0F4JNN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_09120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000197">
        <property type="protein sequence ID" value="KJY35815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946897.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5119"/>
    <dbReference type="EnsemblBacteria" id="KJY35815">
        <property type="protein sequence ID" value="KJY35815"/>
        <property type="gene ID" value="VR44_09120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5088"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY35815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22722" checksum="BA1E314CA53FD098" modified="2015-06-24" version="1">MSVVATATTVDTGHAHPTVNRPNLVSVGTIIWLSSELMFFAALFAMYFTLRSVMGAEHWTEQASALNLPFSATNTTILVLSSLTCQLGVFAAERGDVKKLRTWFIITFVMGAIFIGGQVFEYTDLVKEEGLSLSSDPYGTVFYLTTGFHGLHVTGGLIAFLLVLGRTYAAKRFTHEQATSAIVVSYYWHFVDVVWIGLFATIYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNY3</accession>
    <name>A0A0F4JNY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muconolactone delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000274">
        <property type="protein sequence ID" value="KJY34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947348.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000274.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34641">
        <property type="protein sequence ID" value="KJY34641"/>
        <property type="gene ID" value="VR44_11540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6217"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="MIase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23437" checksum="A691C538408FD748" modified="2015-06-24" version="1">MEYLVTMTTRVPEGTSETEVDEIRAREAAHTRELAAQGRVLRLWRPPLGPGEWRTIGLFAADGPDDLERTLASMPLRIWRTDEPIPLGAHANDPGSGTVPLAADEGEYLVTFNVAVPEGTDSQAVEEVESGEARRAQELAAEGRLVRLWTLPGHGRNLSLWQAPAADVLHRALDSLPMTAADWLTSETVPLTRHPSDPATVKRDEPTPGAAGTPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP05</accession>
    <name>A0A0F4JP05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pup deamidase/depupylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947083.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3215"/>
    <dbReference type="EnsemblBacteria" id="KJY35478">
        <property type="protein sequence ID" value="KJY35478"/>
        <property type="gene ID" value="VR44_10120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5624"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="503" mass="56943" checksum="77A143A7049D8CC2" modified="2015-06-24" version="1">MTVRRVMGIETEYGISVPGHPNANAMLTSSQIVNAYAAAMHRARRARWDFEEENPLRDARGFDLAREAADSSQLTDEDIGLANVILTNGARLYVDHAHPEYSSPEITNPLDAVLWDKAGERIMAEAAERAAQLPGAQPIHLYKNNTDNKGASYGTHENYLMKRETPFSDIVRHLTPFFVSRLVFTGAGRVGIGQDGREHGFQISQRADYFEVEVGLETTLKRPIINTRDEPHSDAEKYRRLHVIIGDANLSEISTYLKLGTTALVLSMIEDGFINVDLAVDQPVRTLHQVSHDPDLQHLITLRSGRTLTAVQLQMEYFELARKYVDERFGTDADEQTKDVLSRWEDVLGRLETDPMSLAGELDWIAKREILEGYRRRDGLGWDAARLHLVDLQYSDVRPEKGLYNRLVARGKMKRLLEEPAVERAQSKPPEDTRAYFRGRCLEQYADDVAAASWDSVIFDLPGRDSLQRVPTLEPLRGTRKHVKELLDRCRTAEDLVRVLSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPD3</accession>
    <name>A0A0F4JPD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35704">
        <property type="protein sequence ID" value="KJY35704"/>
        <property type="gene ID" value="VR44_09330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5194"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="46195" checksum="622CAFCF20696131" modified="2015-06-24" version="1">MAGTAVTLAVIASITAWILSHNGYLPGDAVVRTWAAAKDRPADGRPSGTWVVGDVAVRSRFDAVTGFGIADGQNGKKLWEYVPPGRSQICGSARHADASVLLVAYGEEGGGASEPAPQGKGCATVLALDVKDGRQLWTAQRTVTTGRLGQGARFLDTGRDLALVAHDHRDALGARTKDEHTSLRALDLRTGKPRWTAALPDRCGPQQVSVGKEQVFAVLECGGADRVSPGSSDGPELMTAAFNRETGALNWNVPVDARRPVRLGSTVAIESTDPLVLSDTGRYTPFGQDGRPRPGIEFSGGRGRTGEPDYPQTAITGERMYALEGFWEKGQRHRLVAFDLTTGEEVWKVTLDDPAAALTARGDRITVLGEWSTQSSKITDLLEYDADNGEELDDRRFRDAVPGAGTLYEHDGQLIIAGTGGDHTFTAYERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQG1</accession>
    <name>A0A0F4JQG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946795.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene965"/>
    <dbReference type="EnsemblBacteria" id="KJY36089">
        <property type="protein sequence ID" value="KJY36089"/>
        <property type="gene ID" value="VR44_08565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4855"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23418" checksum="8DB20221C6D90F06" modified="2015-06-24" version="1">MRVVIAEDSVLLREGLTRLLTDRGHDVVAGVGDAEALIKTVGDLAAEGALPDVVVADVRMPPTHTDEGVRAAVQLRRDHPGIGVLVLSQYVEEQYATELLAGSSTGVGYLLKDRVADVREFLDAVVRVAQGGTALDPEVVAQLLGRSRKQDVLAGLTPREREVLGLMAEGRTNSAVARQLVVSDGAVEKHVSNIFMKLGLSPSDGDHRRVLAVLTYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQP8</accession>
    <name>A0A0F4JQP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">VR44_10510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947154.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2389"/>
    <dbReference type="EnsemblBacteria" id="KJY35261">
        <property type="protein sequence ID" value="KJY35261"/>
        <property type="gene ID" value="VR44_10510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5845"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="54" mass="6573" checksum="FE5EAE08E8E5669C" modified="2015-06-24" version="1">MARNEMRPVIKLRSTAGTGYTYVTRKNRRNDPDRLVLRKFDPVVRRHVDFRQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR49</accession>
    <name>A0A0F4JR49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_08360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000170">
        <property type="protein sequence ID" value="KJY36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946756.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5028"/>
    <dbReference type="EnsemblBacteria" id="KJY36228">
        <property type="protein sequence ID" value="KJY36228"/>
        <property type="gene ID" value="VR44_08360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4571"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="437" mass="48708" checksum="A246D897269F707C" modified="2015-06-24" version="1" fragment="single">MDKQQEFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPGTFQILPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRILAKTSDLGFTFYTHPEIEFFLLKDKPLDGTRPVPADNSGYFDHTPQNVGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNIMTFRLVMKQVALEQGVQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFYESGAEYQLSKVGRSFIAGLLKHAAETAAVTNQWVNSYKRIWGGSSRTAGSGGEAPSYICWGHNNRSALIRVPMYKPGKTGSSRVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPAGADDDVWALSDAERRAMGIEPLPQNLGEAISLMERSELVAETLGEHVFDFFLRNKKQEWEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTI9</accession>
    <name>A0A0F4JTI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7115"/>
    <dbReference type="EnsemblBacteria" id="KJY37682">
        <property type="protein sequence ID" value="KJY37682"/>
        <property type="gene ID" value="VR44_05290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1692"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="549" mass="58881" checksum="09F58B8A6B88F767" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTR0</accession>
    <name>A0A0F4JTR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_05490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000101">
        <property type="protein sequence ID" value="KJY37540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946223.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37540">
        <property type="protein sequence ID" value="KJY37540"/>
        <property type="gene ID" value="VR44_05490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1735"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="489" mass="51490" checksum="F86917E55887D77D" modified="2015-06-24" version="1">MLDQGQAPPLSPETRKPVNPLMRRKPVERLVSEGGQGEGGTLRRSLTMWQLTMISIGATLGTGIFVVLGTAAPKAGPAVTISFVIAGLTALFSALSYAELAGSVPVSGSSYSYAYATMGELIAWICGWCLVLEYAVSVAAVAVGWGQYLNELLDGTIGITIPEAVSQPYGQGGFINLPALVVVLLSMVFLMRGAKESATVNSIMVAVKIVTLILFIGIGVMGIKSGNYTPLAPLGVTGISAAASTLFFSYIGFDAASTAGEEAKNPKKDLPRAIMLSLGIVTVLYVLVAFVAVGAMPWKDFEGTEAALAQIMTDVTGTSVWGVVLAAGAVIAIFSVVFAVLYGQTRILFAMSRDGLVPKVFAKVDEKTGAPRANVVIVSLFCGVLAAFIPLGKLADATSIGTLFAFGLVNIAVIILRYTKPDMPRTFKVALFPVTPILGFLACGYMMFSLDLPTWIVFGGWMAVGLVVYFTYGIRRSRLATEEVATAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTS0</accession>
    <name>A0A0F4JTS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37143">
        <property type="protein sequence ID" value="KJY37143"/>
        <property type="gene ID" value="VR44_06375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3184"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="26111" checksum="EED0EB1B9027F6E4" modified="2015-06-24" version="1">MASDETATPEPPKKPTTTISATAYRVLRLLPLKLSAAQYGLASKAIEEAVAKVDGDVERVSYRVHGRLADERHPVREPYGWLITRGLRNDQCPAAECESGRIWPTGADCPTCRERYADRRGTPLIFRDRATAIYEVTWTCSGCERPGTGEVPADGTCDGCRHAANTIKAALTAYHLPPAYENGLRMPDRWRCAEDGCQQVTEGARPDHGRCWRCAPKYKRRQRTHRRWQTGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVM4</accession>
    <name>A0A0F4JVM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">VR44_04045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000074">
        <property type="protein sequence ID" value="KJY38210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945958.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene736"/>
    <dbReference type="EnsemblBacteria" id="KJY38210">
        <property type="protein sequence ID" value="KJY38210"/>
        <property type="gene ID" value="VR44_04045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8714"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="31200" checksum="3C4914F78F742F83" modified="2015-06-24" version="1">MAVVTMRELLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLLQSLSYIDRAYEFVKETVAHGGSIMFVGTKKQAQEAIAEQATRVGMPYVNQRWLGGMLTNFSTVYKRLQRLKELEAIDFEDVAASGLTKKELLVLSREKAKLEKTLGGIREMSKVPSAVWIVDTKKEHIAVGEARKLHIPVVAILDTNCDPDEVDYKIPGNDDAIRSVTLLTRVIADAVAEGLIARSGAATGDSKPGEKAAAEPLAEWERDLLEGEKKADAEAPAAEAPAAEAPAADAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVQ1</accession>
    <name>A0A0F4JVQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">VR44_03570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945877.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5751"/>
    <dbReference type="EnsemblBacteria" id="KJY38427">
        <property type="protein sequence ID" value="KJY38427"/>
        <property type="gene ID" value="VR44_03570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8252"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="46713" checksum="D7C9CC057846F62E" modified="2015-06-24" version="1">MTETPALHPLWPAPLADGAVHATVTVPGSKSVTNRALVLAALAAEPGWVRRPLRSRDSQLMSDALRALGVGIEETVSSSSSAGAGAGGEAWRIIPAALHGPATVDVGNAGTVMRFLPPVATLAAGDIRFDGDPRSYERPLGEVINALRALGARIDDDGRGALPMTVHGGGALEGGTVEIDASNSSQFVSALLLSAPRFNQGVEVRHTGATLPSMPHIRMTVEMLRAAGAQVDTPEAGGEKNVWRVAPSALLGRDMVVEPDLSNAQPFLAAALITGGTVTIPDWPHRTTQPGDELRRIFTEMGGSCELTDAGLVFTGTGAIHGIDVDLGEVGELTPGIAAVAALADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRKLHGGVFHTYDDHRMATAGAVIGLAVKGVEIENVATTAKTLPDFPKMWTDMLAGAEAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVQ3</accession>
    <name>A0A0F4JVQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein VR44_04010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945949.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene742"/>
    <dbReference type="EnsemblBacteria" id="KJY38245">
        <property type="protein sequence ID" value="KJY38245"/>
        <property type="gene ID" value="VR44_04010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8707"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13353" checksum="42D3CD408B1B1918" modified="2015-06-24" version="1">MNAKGVARQALGRYGEELAVRRLTESGMTVIARNWRCRGGEIDIVARDGDALVVCEVKTRREGDFEHPMAAVRAGKAERLRRLAGRWLADHGGPPPGGVRIDLVGVLLPRRGAPVVEHVRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW37</accession>
    <name>A0A0F4JW37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_06300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946373.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37196">
        <property type="protein sequence ID" value="KJY37196"/>
        <property type="gene ID" value="VR44_06300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3014"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471103" evidence="6">
        <location>
            <begin position="35"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="179"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="514" mass="52772" checksum="081C147E68189A98" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW99</accession>
    <name>A0A0F4JW99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946001.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38119">
        <property type="protein sequence ID" value="KJY38119"/>
        <property type="gene ID" value="VR44_04270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.144"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="11198" checksum="BE597820FD9288B5" modified="2015-06-24" version="1">MRVMLRAHLDTAASNEAIKTGALVQALRKFLDRIRPEAAYFGLHEGVRSCWIVFDLQDSAQAPLLTWDLFSRFHAEIDITPVMTGEELTEILSEVRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWM0</accession>
    <name>A0A0F4JWM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000061">
        <property type="protein sequence ID" value="KJY38530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38530">
        <property type="protein sequence ID" value="KJY38530"/>
        <property type="gene ID" value="VR44_03455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470953" evidence="1">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26043" checksum="D2A4D23BC0DFD032" modified="2015-06-24" version="1" fragment="single">MDTRRLLRTTGTVIAAAGLLLSGCTSGSPDVASASAEPSAVPAGLRPYYAQKLSWRDCGVQGFQCSTMKAPLDYANPGSGQDVDIAVARRTATGPGKKLGSLVVNPGGPGGSGIGYLQAYAGIGYPAAVRARYDMVSFDPRGVARSSPVECLTGPAMDRFTQVDQTPDDQAERARLVAAFKEFAAGCEQRSARILPHVSTVDAARDMDLLRAVLGDEKLNYVGASYGTFLGATYADLFPGRVGRMVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWU1</accession>
    <name>A0A0F4JWU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein VR44_03175</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945808.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6557"/>
    <dbReference type="EnsemblBacteria" id="KJY38605">
        <property type="protein sequence ID" value="KJY38605"/>
        <property type="gene ID" value="VR44_03175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7850"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11711" checksum="20C6935E9247C1DD" modified="2015-06-24" version="1">MIPGGGQPNMQQLLQQAQKMQRDLATAQEELARTEVEGQAGGGLVKATVTGSGELRALVIDPKAVDPEDTETLADLVVAAVQAANENAQALQQQKLGPLAQGLGGAGSGIPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX47</accession>
    <name>A0A0F4JX47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945712.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38927">
        <property type="protein sequence ID" value="KJY38927"/>
        <property type="gene ID" value="VR44_02660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6838"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27777" checksum="2BFDD7F307B82F39" modified="2015-06-24" version="1">MSATRSTAAGKVLDVLAAFDREHPAQTLSEIAQRTGLALSTTHRVVAELAAWGALERGEDGSWHVGLRLWEIASGCPRTQILRDVALPFMQDLYEATHENIQLAVREGAELVFVERIAGHRSVELVTMVGARFPIGSTGMGRVLLAHAPVDIQEEVLESPLRAWTPHTVTDPRTLRAQLDRIRREQVFVSDRQLSESTVAVSAPVRIGRNGPVSAALGIVITSRGASRARGLREPLLRAAYGISDELGRRTRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXG3</accession>
    <name>A0A0F4JXG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37681">
        <property type="protein sequence ID" value="KJY37681"/>
        <property type="gene ID" value="VR44_05240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1682"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="31622" checksum="33D5AE9AEB20C37E" modified="2015-06-24" version="1">MLAVTVAVTACGAQGEIMMSEQQATDRAEEIIQQAVVTLSPKPTLERFGPETIGPCLAKDDHSPDDRLQVTLFYKLTGVPGAEARNLVLQAREAWLKQGYKIHSSDEKDMSGPFPWVSMRTEPDDFWMEATTGVLDRATGEGIASLSVTSPCFLPPGKASARGADPAAFEAPEADDPAVRRALAHSSRIYDALGVGSAPTQPGEGLSTVRDGLGTAVHHTWSTLPLPEDERARAVQRAHEYFRDAGWKVRTVPTLEGLPAVVAGHPGEHTIAQVAASTTGAVRVAVTRPLGGPTSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXJ9</accession>
    <name>A0A0F4JXJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000065">
        <property type="protein sequence ID" value="KJY38453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38453">
        <property type="protein sequence ID" value="KJY38453"/>
        <property type="gene ID" value="VR44_03535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15133" checksum="B658403D2EC62AD2" modified="2015-06-24" version="1" fragment="single">MTQEAHVTQGPLTTEAGAPVADNQNSETAGVGGPVLVQDQLLLEKLAHFNRERIPERVVHARGAGAYGTFTVTADVTKYTRAKFLSEVGKQTETFLRFSTVADSLGGADARRDPRGWALKFYTEEGNYDLVGNNTPVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXK7</accession>
    <name>A0A0F4JXK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945633.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39107">
        <property type="protein sequence ID" value="KJY39107"/>
        <property type="gene ID" value="VR44_02245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5714"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8594" checksum="B7ECE9ECFF8D2CFC" modified="2015-06-24" version="1">MQSAIREWRGWTGAAPFWLNSVLLSLAPFTAVPLFAQIGVITALAALGGLARQLWYGDYGHPVMHLAAALMGAAAVVFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXS5</accession>
    <name>A0A0F4JXS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">VR44_03090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945791.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6535"/>
    <dbReference type="EnsemblBacteria" id="KJY38639">
        <property type="protein sequence ID" value="KJY38639"/>
        <property type="gene ID" value="VR44_03090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7833"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="46121" checksum="646B6F79A1DA5855" modified="2015-06-24" version="1">MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELRGLNERGIDTSKLLISGNAHLITPYNVTLDKVGERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILSQKVEAALENKNQLLAKLYNRRAIEVDAIVEEMLQYAEQIKPYVADTTLILNNALDEDKVVLFEGGQGTLLDVDHGTYPFVTSSNPTAGGACTGTGVGPTKISRVIGILKAYTTRVGAGPFPTELFDEDGEALRRIGGERGVTTGRDRRCGWFDAPIARYATRVNGLTDFFLTKLDVLTGWEEIPVCVAYEIDGKRVEELPYSQTDFHHAKPIYETLPGWSEDITKAKTFADLPKNAQNYVKALEEMSGAPISAIGVGPGRTETIEINSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY62</accession>
    <name>A0A0F4JY62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39322">
        <property type="protein sequence ID" value="KJY39322"/>
        <property type="gene ID" value="VR44_01845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5773"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="10"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="41282" checksum="E6D80175D8BBF1D2" modified="2015-06-24" version="1">MVAHGQSAAVVVTGVGALTPIGTTVGEFWDAAVKGSVGTAPITLCDVTGLPHRMGGEVKGFGDAASGLPRSTQLAVAAGLAAAADAGVRPWTSDPARAGVCMGTLLGNRAAVEAGVMRFHRGEPPAAIDGLDPAPPLADLADAVSRELGFMGPSVVVSTACASGNSALAYAADTIRANRADVMIAGGVDEMSSALLMLFTSLRSIAPDVARPFDRNRAGLLVAEGSAALVLESYEHARRRGARVYAELAGWSSASDAYHMTAPHPEGRGARRSMERALAQAGVPADRVGYISAHGTGTPSNDRVEARAIRDVFGARTPAVSSLKGALGHAQGAASAIEAVGCVLAIRDGVIPPTANLVDADPECALDLVSLEAREARVDVAVNNAFGFGGNTGCTVFTRLGSRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ34</accession>
    <name>A0A0F4JZ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_03870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000071">
        <property type="protein sequence ID" value="KJY38276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene768"/>
    <dbReference type="EnsemblBacteria" id="KJY38276">
        <property type="protein sequence ID" value="KJY38276"/>
        <property type="gene ID" value="VR44_03870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471488" evidence="4">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="27339" checksum="D93717F0294A7F51" modified="2015-06-24" version="1" fragment="single">MHLKSLTLRGFKSFASATTLRFEPGITCVVGPNGSGKSNVVDALSWVMGEQGAKSLRGGKMEDVIFAGTTGRPPLGRAEVSLTIDNSDGALPIEYAEVTITRIMFRGGSSEYQINGETCRLLDIQELLSDSGIGREMHVIVGQGQLDSVLHADPMGRRAFIEEAAGVLKHRKRKEKALRKLDAMQANLARVQDLTDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVALRAALDAEIADEAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZH5</accession>
    <name>A0A0F4JZH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945500.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4196"/>
    <dbReference type="EnsemblBacteria" id="KJY39510">
        <property type="protein sequence ID" value="KJY39510"/>
        <property type="gene ID" value="VR44_01555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4744"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471016" evidence="2">
        <location>
            <begin position="31"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="104"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="580" mass="62204" checksum="013DBE91EC85D7FF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZW0</accession>
    <name>A0A0F4JZW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39675">
        <property type="protein sequence ID" value="KJY39675"/>
        <property type="gene ID" value="VR44_00900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2890"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471027" evidence="2">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="19528" checksum="6927DD2164A89431" modified="2015-06-24" version="1" fragment="single">PSGSTGPGRRRARRRIAVLTGLAGVAACVLGVLLFNGPAGTGAHDTATSNNTVRAAGSAAPGEYTAQGLQQNVHRLLAAAPSANAPKTAPGESNRTMELENASPGLAPAERPGSPEPAPAAVPPCVQRATGRTEMPLAAEPGRYQGTPVYLVVLPHPGDPARVDAYLVAAGCADNPSASPEKPLFTRTYPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0G6</accession>
    <name>A0A0F4K0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_02960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945775.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38746">
        <property type="protein sequence ID" value="KJY38746"/>
        <property type="gene ID" value="VR44_02960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7324"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="5">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23313" checksum="5B6ED0F7E887002C" modified="2015-06-24" version="1">MDVRRAADRYAGGDPEAGITTRHAFSFGSFYDPENIRFGPVLACNEELLAPGSGFDEHPHSHTEIVTWVVEGELTHRDSTTGHTGTVRPGDVQRLGSGSGARHVERNDGDRPLRFVQMWLAPLAAGGEPSYEVVRGLADGTPYEVPAAGAVLHVLRPGAGERVPVPEAERVYLHVVHGDLRLDGAELGPGDSARITAEKGLEVTAGSPCELLVWELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0G7</accession>
    <name>A0A0F4K0G7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_00125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945265.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene991"/>
    <dbReference type="EnsemblBacteria" id="KJY39905">
        <property type="protein sequence ID" value="KJY39905"/>
        <property type="gene ID" value="VR44_00125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.23"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15285" checksum="9B03FE02BE85EB9F" modified="2015-06-24" version="1">MTAQIQYADVEVGTELPAASFPVTRATLVRYAGASGDFNPIHWNEKFAKEVGLPDVIAHGMFTMAEAIRVVTDWVGDPGAVVEYGVRFTKPVVVPNDDQGALIEVTAKVAQKLDDNRVRVDLTAMSAGQKVLGMSRAVVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0M7</accession>
    <name>A0A0F4K0M7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">VR44_00320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030008467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1032"/>
    <dbReference type="EnsemblBacteria" id="KJY39940">
        <property type="protein sequence ID" value="KJY39940"/>
        <property type="gene ID" value="VR44_00320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.62"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10632" checksum="BA145796C8B7ABFD" modified="2015-06-24" version="1">MSENNVTEKTERGFRKTREGLVVSDKMDKTVVVAVEDRVKHALYGKVIRRTNKLKAHDEQNAAGVGDRVLIMETRPLSASKRWRIVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K117</accession>
    <name>A0A0F4K117_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39628">
        <property type="protein sequence ID" value="KJY39628"/>
        <property type="gene ID" value="VR44_01045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2922"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13446" checksum="0293FAADF8768043" modified="2015-06-24" version="1">MTNFVVKTLANAGALAVAIWLLSGITLDDGSSLGRRALTLILVALVFGLVNLIVKPVVKLLSIPLFILTLGLFTLVVNALMLLLTSWVAEQVHLSFHVDGFWTAVLGGLIISVVSWALNLALPDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K216</accession>
    <name>A0A0F4K216_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">VR44_00435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945297.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1055"/>
    <dbReference type="EnsemblBacteria" id="KJY39963">
        <property type="protein sequence ID" value="KJY39963"/>
        <property type="gene ID" value="VR44_00435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.85"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16186" checksum="D8277B18EC0EF729" modified="2015-06-24" version="1">MRTYSPKPGDISRQWLVIDAQDVVLGRLATQAAALLKGKHKPTYAPHMDMGDFVIVINADKVHLSGNKASQKMAYRHSGFPGGLRSVRYDDLLANNPEKAVEKAVKGMLPKNSLGRQMLSKLKVYSGDQHPHAAQQPVPFEITQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1W6</accession>
    <name>A0A0F4I1W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001804">
        <property type="protein sequence ID" value="KJY15995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15995">
        <property type="protein sequence ID" value="KJY15995"/>
        <property type="gene ID" value="VR44_40655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="11795" checksum="D28F96ECF6BF3DD9" modified="2015-06-24" version="1" fragment="single">GTNAHVVIEEPAPHADPEPRRAAEDAPATETAVVWPLSAKDPAALRAQAGRILAHLAAHPDLHPRDVALSLAPRAALDLRSAVVGARREDLVSGLEDLLAGRPTAAAFLRGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I274</accession>
    <name>A0A0F4I274_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl-synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001859">
        <property type="protein sequence ID" value="KJY15789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15789">
        <property type="protein sequence ID" value="KJY15789"/>
        <property type="gene ID" value="VR44_40830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="6811" checksum="BAACDB137FC4874D" modified="2015-06-24" version="1" fragment="single">QDGASNGLTAPNGPAQERVIEQALANAGLSAADVDAVEAHGTGTRLGDPIEAQALLATYGQDRAGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I658</accession>
    <name>A0A0F4I658_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001669">
        <property type="protein sequence ID" value="KJY17427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17427">
        <property type="protein sequence ID" value="KJY17427"/>
        <property type="gene ID" value="VR44_39980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6332"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="10803" checksum="2A7196C764478361" modified="2015-06-24" version="1">MTVKAEPDGVWRIVCAGEFDLDTTGKLEAACQGEAAGARLLVIDVTGVAFADSSFLNVLIRLRNTRPVVLAGPLPHQLERLLEMTGARALFTIRDGQAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAU6</accession>
    <name>A0A0F4IAU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001567">
        <property type="protein sequence ID" value="KJY19112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952471.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001567.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene111"/>
    <dbReference type="EnsemblBacteria" id="KJY19112">
        <property type="protein sequence ID" value="KJY19112"/>
        <property type="gene ID" value="VR44_39235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5649"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="32976" checksum="D070A7568707E042" modified="2015-06-24" version="1">MRLGVLDVGSNTVHLLVVDAHPGARPLPAHSHKEQLRLAELLDEHGAITPEGVERLVSVIGEAVQAAEDKGCEDVLPFATSAVREAPNADEVLARVKAETGVELPVLSGEDEARLTFLAVRRWFGWSAGKLLVLDIGGGSLEIAYGIDEDPDAAVSLPLGAGRLTSAWLPADPPDPADVKALRRHVRAQIARTVGEFSRFGAPDHVVATSKTFKQLARIAGAAREADGLYVQRDLTRKSLEEWVPRLSAMTTAERSTLPGVSEGRASQLLAGALVAEAAMDLFGVDTLEICPWALREGVILRRLDHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBG1</accession>
    <name>A0A0F4IBG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001583">
        <property type="protein sequence ID" value="KJY18828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952503.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001583.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18828">
        <property type="protein sequence ID" value="KJY18828"/>
        <property type="gene ID" value="VR44_39395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5966"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469382" evidence="1">
        <location>
            <begin position="26"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24678" checksum="D54EFCAB86F513B3" modified="2015-06-24" version="1" fragment="single">SSPARARRRAGVALLGLAAVLPLLAGCGNTGGLDSAGPTPTAIGPVHLWPERKGAVVPPADPGGAPPEYVQGLPPVTGQDVHSVDPVALVQAELRAHPNTDVGPDGMPPETAAAIRACGREGQAPGACPVLAPYYRDLTGNGKDEVVVGVEFPDRMMSVRVYTADEDGRLNRIMATTQTVISVELAGQDVILRVPSGNPGYELITAWSWDAKQRTMLPAREEIVRVPAVPAVSAQGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGB5</accession>
    <name>A0A0F4IGB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001499">
        <property type="protein sequence ID" value="KJY20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20488">
        <property type="protein sequence ID" value="KJY20488"/>
        <property type="gene ID" value="VR44_38660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5407"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="444" mass="48055" checksum="E1CFD82110BA4B99" modified="2015-06-24" version="1">MVLGAGLAGLLTARVLAEHFPRVTVLDRDELPETGPAFRPGVPQSRHAHILWSRGIEVMERLLPGTTAELTGAGAALLESPRDLLWLSPADWFQPVPGARVLIAGRELLDWMVCRAVRRDRRIEVLGGRFVTGLVAGPDGRSVTGVTLRDRPPLAARLVVDATGRTSRAPAWLAALGYPAPEVTRYDSHLGYSSRVYALPAAPGTAGSRLQGRTDSPRGGVLVPLEDGRWLATLVGNGEHAPPTKDPEFLEFTRTLRSPALYEAIRDGEPLTEPTGFRATANEWRHYERMDRWPDGLLVVGDAACRFNPVYGHGMTVAATAAHALDQALAGLPARRIPAECRALQRRTVAAADVAWQIATSEDLRYPWTEGPPPDRATRILQRYMSRVMAGANTDPALSSAFFGVLSLSTPPAALLTPGTVLRVLSKWRLPTAPDAPPYPAHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIH9</accession>
    <name>A0A0F4IIH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001442">
        <property type="protein sequence ID" value="KJY21817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21817">
        <property type="protein sequence ID" value="KJY21817"/>
        <property type="gene ID" value="VR44_38160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5237"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="21993" checksum="CE6BC488C4DEC7C1" modified="2015-06-24" version="1" fragment="single">MQIRLTVLGSRGGHQAATAPAGCDVLVTAPAGTALAAVASGLAATVGGPDTGGTVVLYAGSRRLDLQRTVLGEPPLVDGAVLTLHVPAPEADALGDDGLGAPQLQVVAGPDAGGVHLLHPGSVRIGRSADADVPLDDPDVSRLHCTVTVMPDGRVAVADLGSTNGTTLDGTPVGVRAVPLPPGALLRIGESTLRLATGAGPRLRVVPDLEGHLALTDASGGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIP5</accession>
    <name>A0A0F4IIP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001451">
        <property type="protein sequence ID" value="KJY21549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21549">
        <property type="protein sequence ID" value="KJY21549"/>
        <property type="gene ID" value="VR44_38240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7409" checksum="F7972D73AD6F4D5E" modified="2015-06-24" version="1" fragment="single">AQAGAPAAPAAGPGVTLPGSPRRIDLDVTVRSTGTSWAAVSLLLRDRFGVTHTTQRATLPTGGDGTLRFPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJ72</accession>
    <name>A0A0F4IJ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001434">
        <property type="protein sequence ID" value="KJY22037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22037">
        <property type="protein sequence ID" value="KJY22037"/>
        <property type="gene ID" value="VR44_38080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="15991" checksum="02079755F6C7579E" modified="2015-06-24" version="1" fragment="single">MPPPPPPAGLPDQEPAVTPADIRDGAAVALVVGVSGALLALLWAWLAPRVQYVAHGQAVFLKNTEGEARIGADGTFFLLSLGLGVLSGLAVFLWRRRGGVALVAGLTVGSCFAAVVGWRMGLWLGPGTDVVAAAGKAGEDVPFDAPLQLLAYGVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IK11</accession>
    <name>A0A0F4IK11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_38165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001442">
        <property type="protein sequence ID" value="KJY21818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952272.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21818">
        <property type="protein sequence ID" value="KJY21818"/>
        <property type="gene ID" value="VR44_38165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5238"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY21818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="593" mass="64277" checksum="E3F7D2A6FD47259C" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ19</accession>
    <name>A0A0F4IQ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001365">
        <property type="protein sequence ID" value="KJY23774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952109.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001365.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23774">
        <property type="protein sequence ID" value="KJY23774"/>
        <property type="gene ID" value="VR44_37300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4873"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469729" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21844" checksum="393BF8265FE53EFF" modified="2015-06-24" version="1">MRPFRIPGRAAGATALGAALLAGATLFTAPTASGHGYTDTPISRQKLCANKTVPDCGPIQWEPQSVEGYKGFPAAGPADGQICSGGHSEFAQLDDPRGGTWPATRVNSGQSFDFRWQFTANHSTTDFKYYVTKNGWDPTKPLTRASLDPQPFLVVPYNGGRPDMTTIHRGTMPGGKTGRHMILAVWTVNDTAMAFYACSDVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ73</accession>
    <name>A0A0F4IQ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001352">
        <property type="protein sequence ID" value="KJY23824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952083.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23824">
        <property type="protein sequence ID" value="KJY23824"/>
        <property type="gene ID" value="VR44_37145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4818"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="377" mass="39884" checksum="DA534F2C4CC2BBBE" modified="2015-06-24" version="1">MRAPWRSPPEPGADGRHQIRFALAEGLPFAIALVVLVIELTPAHVVYTGPLLVATPALAAVTLGPAGTLAAAGVALCVSVATATYNHAWGGQLVYTNLLALALVTTASVMTSRAVGARRDQELQQVRRIAEAAQEVLLRPVPARLGPVRAASMYLAAETGAQIGGDLYDAVQTRYGVRLIVGDVRGKGLPAVRAAAVVLGAFREAVHYEDDLVEVVHHCGAALRRDAGTASAGLAGGDDALLEGFVTAVVAQIPDTPDVQVVNRGHPPPLLLRDGEVRPLTPTAPLPPLGLEEFISGRPGRTDSYPFLPGDRLLLHTDGAIEARDAENTFFDLAGAVRTLRDRTRQSFLEDLRRALLRHACGRLADDVAIVVVDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQR5</accession>
    <name>A0A0F4IQR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_36615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001314">
        <property type="protein sequence ID" value="KJY23999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951985.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001314.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23999">
        <property type="protein sequence ID" value="KJY23999"/>
        <property type="gene ID" value="VR44_36615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4632"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="29090" checksum="8105D2BAE543E6E1" modified="2015-06-24" version="1">MPQLGFGVWQVPDAEAERVVGDALEAGYRSVDTAAVYGNERGTGRAVNGSGLPREELFVTTKLWNGPDRRWDRDAVLRAFDDSLGKLGLDHVDLYLIHWPRPMRDDFLTIWKTFEEIAASGRARAVGVSNFRPADLERLGAESSLVPAVNQIELHPLFPQPELRALHARLGIATEAWSPLGQGKELLELPAVAAVAAKHGRSAAQVVLRWHLQLGTIVIPKSVTPSRIRENLDVFGFELDAEDLAALDALGADGRRIGPDPAVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQZ4</accession>
    <name>A0A0F4IQZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001229">
        <property type="protein sequence ID" value="KJY24430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24430">
        <property type="protein sequence ID" value="KJY24430"/>
        <property type="gene ID" value="VR44_35410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6938" checksum="230FAE001F817C3D" modified="2015-06-24" version="1" fragment="single">LRALPLALDRYGITLRLEERTGHHDVRLPFPSPLDDVEQSGTQIQALLSAARRRSHPNTLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISF7</accession>
    <name>A0A0F4ISF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001198">
        <property type="protein sequence ID" value="KJY24589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951664.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001198.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1758"/>
    <dbReference type="EnsemblBacteria" id="KJY24589">
        <property type="protein sequence ID" value="KJY24589"/>
        <property type="gene ID" value="VR44_34920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4060"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11950" checksum="5EBF286E25089FCD" modified="2015-06-24" version="1">MIFIAVRFDVRPEHSDNWLALVDDFTRATRSEPGNLFYDWSRSVDDPNKYTLLEAFTDAEAGAAHVASEHFKAGMETLAGAIATTPEIIHVEVPGQGWSAMAELSPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISH9</accession>
    <name>A0A0F4ISH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001194">
        <property type="protein sequence ID" value="KJY24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951652.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001194.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24614">
        <property type="protein sequence ID" value="KJY24614"/>
        <property type="gene ID" value="VR44_34850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4041"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="30546" checksum="4E20A4727AFAB5A1" modified="2015-06-24" version="1">MAKAANKERAGGATRLVAHLARVLREKAGYTQTELGRKIGYSGAAISAMETCAQPASDEMLVELEREVGWGLGVFEMARGLVRLDKYPAQFQDFIALESRVLTLCMFETLVINGLFQTEAYAQALIAGGYPVLPDRRVAELVEARMERTALFEREPTALIELILDESALLRGVGSPDIMRGQLRHLAELAKRRNVTVQVLPLNCGFTGEHAGARGGLTILETADHEHLAYMEAQDESVMISDPGMVSMYSQRYAKIRAQALGPRESLGLIERLAGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISS7</accession>
    <name>A0A0F4ISS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001129">
        <property type="protein sequence ID" value="KJY25047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951427.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001129.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25047">
        <property type="protein sequence ID" value="KJY25047"/>
        <property type="gene ID" value="VR44_33615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3630"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="10251" checksum="4453E4E84554CF74" modified="2015-06-24" version="1">MSREDNRAGVSALLSWAVWGSLIWIVWDPDLQGVQEAIGWWMIAIALAPVLLMAMWAAVFDEPGAGDDACGSDDGDVHWTHGEESCGSRRYGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITB6</accession>
    <name>A0A0F4ITB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_33030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001102">
        <property type="protein sequence ID" value="KJY25247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25247">
        <property type="protein sequence ID" value="KJY25247"/>
        <property type="gene ID" value="VR44_33030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3478"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY25247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="484" mass="50497" checksum="8E1C8F9B90017DC3" modified="2015-06-24" version="1" fragment="single">MQSRRADYAGFPEYAGQYRLESVLGSGGMGVVHLAASSSGLKLAVKVVHAQHAVDPEFRARFRQEVAAARRVSGAFTAPVVDADPDAERPWMATLFIDAPTLSERVRERVLDAGELTRLAAGLAEALRDIHRAGVVHRDLKPSNVLMAPDGVRVIDFGISRPADSDLRTETGKLIGTPPFMAPEQFQRPREVGTAADVFALGAVLVHAATGRGPFDSDSHYLVAYQVVHSEPDLTGLPARLVPIVARCLAKDPAERPTAEALIAEMRAVAYPTGEDTQAFIPQPRRPVADEEPTHQRRQIATEEPPAARRRRIRPALLAAGLGALLTAGAAGGYLWWAAGPDGPGRPAAHASADPGTAFTPWSVSPGTPPVSCSAAGDGLFCSGPGLAAARLGRADGATAWAVRANAPSFGVSSSTAPSYAAGAVVVVAPGSQLLQVLEPGTGAERWQRKLSAGTRVVTADPYVVTVAADGTVTALDGAGGTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU94</accession>
    <name>A0A0F4IU94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tylosin resistance protein TlrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001129">
        <property type="protein sequence ID" value="KJY25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951428.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001129.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25048">
        <property type="protein sequence ID" value="KJY25048"/>
        <property type="gene ID" value="VR44_33620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3631"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="340"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="551" mass="59100" checksum="B480E702473CC1D2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUM0</accession>
    <name>A0A0F4IUM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001089">
        <property type="protein sequence ID" value="KJY25339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25339">
        <property type="protein sequence ID" value="KJY25339"/>
        <property type="gene ID" value="VR44_32745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3361"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="18079" checksum="36DC4ED64C281611" modified="2015-06-24" version="1" fragment="single">GSAAVQLGKAAGATVIGVVGGKAKARAAEELGCDLVLDRTAEDLVARVKEFTGGRGADVVYDPVGGDAYAASAKCVAFEGRIVVVGFAGGTVPAPALNHALVKNYAILGLHWGLYAAKDPAAVLACHTELTRLADQGAIRPLVSERVPLAGAAEAVQRVADGTTTGRLVVVPSLPDGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWD4</accession>
    <name>A0A0F4IWD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001010">
        <property type="protein sequence ID" value="KJY25924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950983.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25924">
        <property type="protein sequence ID" value="KJY25924"/>
        <property type="gene ID" value="VR44_31250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2737"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27669" checksum="826AF5BA4A391FC6" modified="2015-06-24" version="1">MGKLDGRVVIVTGAARGQGEQEARLFAAEGARVVLGDVLDEQGAAVAEEIAEEHGEDRARYVRLDVSREEDWAAAVAVAKERFGHVDGLVNNAGILRFNELTATPLEEFQQVVQVNQVGTFLGIKAVAPEIGAAGGGTIVNTSSYTGLTGMAYVGAYAATKAAILGLTRVAALELAAQNIRVNAMCPGAVDTPMANPGLLDPAGMADGAREAMAELYQRVVPLGRVGRPEEMAKLALFLTAEDSSYITGQPFVIDGGWMAGVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWZ6</accession>
    <name>A0A0F4IWZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glutamine synthetase</fullName>
            <ecNumber evidence="9">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_30745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000975">
        <property type="protein sequence ID" value="KJY26169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950897.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000975.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5079"/>
    <dbReference type="EnsemblBacteria" id="KJY26169">
        <property type="protein sequence ID" value="KJY26169"/>
        <property type="gene ID" value="VR44_30745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2605"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="10">
        <location>
            <begin position="101"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="6">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY26169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="469" mass="52601" checksum="9631293330C257F2" modified="2015-06-24" version="1">MFKNADEVKQYIEENDVKFVDVRFCDLPGVMQHFTIPARAFDPAEELAFDGSSIRGFQAIHESDMALRADISTARLDPFRRDKTLNINFFIHDPITGEAYSRDPRNIAKKAEAYLASTGIADTAFFGPEAEFYVFDSVRFATSANEGFYHIDSEAGAWNTGSEENNRGYKVRYKGGYFPVAPVDHFADLRAEISLELDAQGLQVERQHHEVGTGGQAEINYKFNTLLAAADDLMLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWQGGEPLFYDEAGYAGLSDTARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPVNMVYSQRNRSAAMRIPITGSNPKAKRVEFRAPDPSSNPYLAFAALLLAGLDGIKNKIEPMEPIDKDLYELSPDEHANVPQVPTSLEDVLKALEEDHEYLLAGGVFTPDLIETWIDYKRTHEIAPIAQRPHPHEFELYFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX49</accession>
    <name>A0A0F4IX49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000923">
        <property type="protein sequence ID" value="KJY26587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950708.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000923.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4960"/>
    <dbReference type="EnsemblBacteria" id="KJY26587">
        <property type="protein sequence ID" value="KJY26587"/>
        <property type="gene ID" value="VR44_29700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2317"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="36520" checksum="55122799EFBEABB9" modified="2015-06-24" version="1">MRLGLALGYWGRGPSPSHLDLATEAERLGYDSVWTAEAWGSDAFTPLTWIAAHTSRIRLGTAIAQMAARTPTATAMHALTLDHLSGGRMMLGLGLSGPQVVEGWYGRPFPASPLTATREYVDVVRQVLRREAPVALDGRFHTHPYRGEDGTGLGKALKPITHPLRADLPLLLGAEGPKNIAQTTRIADGWLPLYWSPTRTDVYQASLTGLPEGFMIAPMARAHVCEDVSEGLLPVKAMLGFYIGGMGHAARNFHADLMARMGYGDEARRIQELFLAGRRQEAVLAVPDAFADEISLVGPRGRIAERLELWRKGPVTDLLVTAPDPHTLRVLADLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXG5</accession>
    <name>A0A0F4IXG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000908">
        <property type="protein sequence ID" value="KJY26730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950644.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000908.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26730">
        <property type="protein sequence ID" value="KJY26730"/>
        <property type="gene ID" value="VR44_29365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2237"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="37138" checksum="724522064FB8FF9E" modified="2015-06-24" version="1" fragment="single">MNPERTLLLVGGTDETVQKAHDLGLNVLLLQHPTKVSELQNRLAAAVEVVDFTEWSLVEPLVRAWHESPGFAAVVSLTEPGLENAGRINDLYGLGGTGYEVTARIRDKAAMRRYVAEHDPEHAVGARSLKTREDLDAFGASYGFPFIVKPVDATASIGVMRVEGPQDADRVWDEVTRLSGTRTDRVSSLFVLKDFLMEEFLDGPEFSVESFSFAGRHVIVTITEKFTSDGHFAELGHAVPARLSEADDAAIREGIRGFLDVMGMRDGVCHTEVRLTAKGPRVIEGHNRIGGDSIPELVLSAFGVDLITLAVGHPFGLVEELPDRPRAHGGAAVRALVGTPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXQ2</accession>
    <name>A0A0F4IXQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000900">
        <property type="protein sequence ID" value="KJY26825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26825">
        <property type="protein sequence ID" value="KJY26825"/>
        <property type="gene ID" value="VR44_29140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2169"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7761" checksum="FC5F4965661D6660" modified="2015-06-24" version="1" fragment="single">MSALPQQHEPEPLPRTANAIAAALNPTRKGTFLEELLAAQAGADMLAVMDRWYLRAVADSTRTDADRPQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXQ6</accession>
    <name>A0A0F4IXQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001073">
        <property type="protein sequence ID" value="KJY25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951222.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25441">
        <property type="protein sequence ID" value="KJY25441"/>
        <property type="gene ID" value="VR44_32495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3303"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18596" checksum="58CFEFB68210D569" modified="2015-06-24" version="1">MTETTAPRRPLAVFDIDNTLADTGHRQHFLEQRPRDWDGFFGAAPADPPLAPGVALAVESAADCEVVYLTGRPERCRADTADWLARHGLPEGRVWMRGDRDRRPARVTKLEVLRRIARGREVRVLVDDDQLVCQAARAAGFQVLLADWAAEAPELKSAQESERGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZL3</accession>
    <name>A0A0F4IZL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000980">
        <property type="protein sequence ID" value="KJY26121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950916.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000980.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26121">
        <property type="protein sequence ID" value="KJY26121"/>
        <property type="gene ID" value="VR44_30850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2628"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="51359" checksum="EBF028D1ED173B19" modified="2015-06-24" version="1" fragment="single">TGPLRVRVAVVGAGISGLTAALTLQDAGIPCTLYEANPARVGGRMWTQRDHWAYGQTSEIGGELIDTSHKKIQELCRRFGLPLEDFLGGGPNGAEEILHFNGSYYPRTQADEDFKAVYQALHRDLQDAGEVSWNSSTPAGTALDNMTLYEWIETRVPGGHGSLLGRFIDVAYNVEYGADTQTQSALALVLLMGYQPNPGNFNVWGLSNERYHVIGGNDRLPNAIAAALNPGTLVMGRSLVAVRANADGTQTLTFDDSGAVRTATADHTILCVPLPILQRLDTSQAGFDPLMRNLLRDARMGYCTKLNMQFTARPWRGTGPWPGVSAGDCFTDSAVQQTWDTTKVQPGNGGILLQYGGGSLAGALTPATPFATESDPYVRDLAGRVLTGVDAFFPGTKAVWTGRAQLSAWHRNPYSLGAYSYWPTGYLHRYAKYEGTAQGNVHIGGEHCSYDFQGFMEGGATEGERAAREVIAALTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZQ3</accession>
    <name>A0A0F4IZQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000976">
        <property type="protein sequence ID" value="KJY26161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950900.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000976.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5081"/>
    <dbReference type="EnsemblBacteria" id="KJY26161">
        <property type="protein sequence ID" value="KJY26161"/>
        <property type="gene ID" value="VR44_30760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2608"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26221" checksum="47C09D8D00076FBA" modified="2015-06-24" version="1">MNRYEGRRVLITGGGSGIGQATVHRILSEGGRVHTVDVNEAGLKATAEQAAAAGHAGRLTTAVLDISDETSVKEGVAAAVDALGGIDVLVNAAGILRSAHTHQTTLDFWNKVIAVNLTGTFLMIRESLPALLAGDQPVVVNFSSTSASFAHPYMSAYAASKGGIQSMTHALAAEYSKQGLRFVSVAPGSIESGMTTGNGPGLPEDTDWSLFAKLAPAIGQGFAGPQTVAGVVAMLGSEDGAFITGTEIRIDGGTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZR1</accession>
    <name>A0A0F4IZR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trans-2-enoyl-CoA reductase (NAD(+))</fullName>
            <ecNumber evidence="4">1.3.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_28750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.44" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000882">
        <property type="protein sequence ID" value="KJY26953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950533.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000882.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26953">
        <property type="protein sequence ID" value="KJY26953"/>
        <property type="gene ID" value="VR44_28750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2082"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024906">
        <property type="entry name" value="Eno_Rdtase_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024910">
        <property type="entry name" value="Enoyl-CoA_Rdtase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010758">
        <property type="entry name" value="Trans-2-enoyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37480">
        <property type="entry name" value="PTHR37480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07055">
        <property type="entry name" value="Eno-Rase_FAD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12242">
        <property type="entry name" value="Eno-Rase_NADH_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12241">
        <property type="entry name" value="Enoyl_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl_reductase" evidence="12">
        <location>
            <begin position="83"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Eno-Rase_FAD_bd" evidence="11">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY26953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="43152" checksum="D168414C03B48B15" modified="2015-06-24" version="1">MSLRQIEPKQRGFLIVNSHPEGAARTVRDMWEAVPARTDGRRPVALVLGHSAGYGLATVVAGLRRHGIRGIGVAFEAPDTGRRTAGAGWYRTAATAELVAEEGHDFRFVNTDAFSDDARSRVADLLEEHYGPVDHLVYSLAAPRRTDPGTGEVHHSVIKPLGAAYEAPALDFSAATPAVTWTRLEPGTDAEARATVAVMGGDDWALWVRALASRGLLADGFTTAALTYVGSEVTAPVYRHGTIGAAKEHLERTARDLDGSALLKEKDGRAFTVVAGAAVTQASTAIPSIALYTSFLRTVLGDGGFRTTAEQAVDLWDQLEGRTPLILDEEGRIRLDGWELDPGVQERVRELWADPQHALDASRSGADWFMKQVRALYGWDVGNVAYGRPVETDVPWPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J006</accession>
    <name>A0A0F4J006_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000875">
        <property type="protein sequence ID" value="KJY27053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950487.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000875.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27053">
        <property type="protein sequence ID" value="KJY27053"/>
        <property type="gene ID" value="VR44_28490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2025"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="35932" checksum="0D056DC4A0B4CC00" modified="2015-06-24" version="1">MNTAQQTVAIFGAYGHTARFLIDEFHERGLGLSLGGRDPVRMTALAEAHPYARTHVATVDEPGSLDALVAGAALVVNAAGPFGDTTGPLIEAALRAGIHYIDITGEQPVTRHDFETYREPLAASGLLFLPALGFFGGLPDLLATAAMGDWAAADDITVAFALDSWHPTPGTRKAGARSAGKRVTVSGGRLVPFDYGQDLPTDWDFPAPVGKQPVHALGTADQITISRHLKSPEVRAFMNEAPLADLRDPHTPAPTGASDGGRSAQSWLIDVVVTRGAERRAVSAVGRDIYAVTAPVVAEAAVRILAGRTLPGGTGSGMRAPGEVFDAEDFLSSIADITWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J035</accession>
    <name>A0A0F4J035_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000854">
        <property type="protein sequence ID" value="KJY27259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27259">
        <property type="protein sequence ID" value="KJY27259"/>
        <property type="gene ID" value="VR44_28015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1854"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="494" mass="48931" checksum="F968DB51A8D05DAB" modified="2015-06-24" version="1">MPWPDASAGGAAGAAAETAYLPPYPGAGEPHPPQRQRPAVPDAWFRDAQPQSPSPAQADAAAQTAYLPPVRQPEPPQGTGGGVPWPDASAGGAAGAAAETAYLPPVRDAADAAAETAYLPPYPVPGQPQAPAVPDAWFRDAQPQLVSPAQADAAAETAYLPPVRDPQPPADAAAETAYLPPVRDAQPPADVAAAETAYLPPVPPVEDAAAQTAYLPPVREAGPEPAAAGAEWSPPTLGGNTLRAVDPAQARAEGRSPIIDPGPQSAILTAALGLLLAGAAALGQYALLLPLIALQGLTAAGWFRLNGMWPARQGIALAFAGALVADGAVLAVDGTYGPGAIIGTLGVWVLLTLVLQLRSHADPDERMYGLMASVASAALAIACTGFLAAGWEAVSTGAAAVAVAVFARALPLPTAPSVGVSLAAAAGAGIAVGGLVGLGAGGALVGLAAGVCALVGLRVAAYDYPSKFVHMTAGVALPLAVAAPVVYLIGRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Y2</accession>
    <name>A0A0F4J0Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950716.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7409"/>
    <dbReference type="EnsemblBacteria" id="KJY26576">
        <property type="protein sequence ID" value="KJY26576"/>
        <property type="gene ID" value="VR44_29745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2328"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="34602" checksum="4C1C822CFB770864" modified="2015-06-24" version="1">MLDEVERWLADRSWSAADRPLDQLLERKRAAGTTVSVVLPALDEEATVGEIVEVIRRDLIEGLPVPLVDELVVVDSASADRTAEVAAKAGARVVHRDEILPRVPAVRGKGEVLWRSLLATTGEIVCFVDADLRDFSSAFVSGIVGPLLTDPQVQFVKAMYDRPLGDAPGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAVRRSLLERLPFPVGYGVELGLLVDALHTVGLDALAQVDVGVRLHRHQDGQALGRMAAAIYRTAQLRLSRGHLVRPALTQFERGPDGFVPRTYAVDTEERPPMLEIEEYAVRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Y9</accession>
    <name>A0A0F4J0Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000838">
        <property type="protein sequence ID" value="KJY27413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000838.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4921"/>
    <dbReference type="EnsemblBacteria" id="KJY27413">
        <property type="protein sequence ID" value="KJY27413"/>
        <property type="gene ID" value="VR44_27620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1759"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6643" checksum="7C83C98814942B6B" modified="2015-06-24" version="1">MPRYEYRCRTCDDTFEVSRPMAESSAPADCPAGHADTVKLLSAVAVGGTSSAPAPSGGGCCGGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J287</accession>
    <name>A0A0F4J287_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000778">
        <property type="protein sequence ID" value="KJY27964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950088.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000778.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27964">
        <property type="protein sequence ID" value="KJY27964"/>
        <property type="gene ID" value="VR44_26325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1420"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22970" checksum="EBBB260AA4AB366F" modified="2015-06-24" version="1">MGLHDDGPGETGALSSDGDLAALALKILVAGGFGVGKTTLVGAVSEIRPLRTEELLSEAGELVDDTGGVERKTTTTVAMDFGRITIRSGLSLYLFGTPGQDRFWFLWDELSQGALGAVVLADTRRLEDCFPAVDYFEHRRIPFVVAVNCFADARRYGANEVSRALDLEQGTPVVLCDARDRDSGKEVLIRLVEYAGRVHTARLLDSVGPQAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2L5</accession>
    <name>A0A0F4J2L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_28215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000860">
        <property type="protein sequence ID" value="KJY27191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950433.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000860.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27191">
        <property type="protein sequence ID" value="KJY27191"/>
        <property type="gene ID" value="VR44_28215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1885"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9164" checksum="18574AE35939CC90" modified="2015-06-24" version="1">MGIIGWIVLGLLAGGIAKILLPGRDPGGLIGTTLIGVAGAFIGGWLSAKFLDRPIENHFFDLATWGSAIAGSLVLLIGYRILFGNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2P6</accession>
    <name>A0A0F4J2P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950416.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27236">
        <property type="protein sequence ID" value="KJY27236"/>
        <property type="gene ID" value="VR44_28105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1864"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="17930" checksum="133D344FE7E6043E" modified="2015-06-24" version="1">METETATRWLTDAEQCAWRTHLDVSRLLMHQLEKDLQPFGLTNNDYEILVNLSEAEGHRMRMSDLATATLQSKSRLSHQITRMEATGLVRRVNCESDRRGLYAVLTDEGMDTMRKVAPHHVASVRENFIDLLPPEALQALHTSLTPVAEHLRGTRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J354</accession>
    <name>A0A0F4J354_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_24565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000702">
        <property type="protein sequence ID" value="KJY28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949761.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3007"/>
    <dbReference type="EnsemblBacteria" id="KJY28782">
        <property type="protein sequence ID" value="KJY28782"/>
        <property type="gene ID" value="VR44_24565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.908"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="119"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35229" checksum="3431B8FBC25F08BC" modified="2015-06-24" version="1">MTAPLHDTSAETPAPVSVADVPAKAIEGRSPGRIAWMRLRRDKVALTGGVVVILLILVAIFAPLIVKLLGHDPNEFHEDLIDPDLGTPLGSLGGISSDYLLGVEPTNGRDVFSRIVYGARISLIVAFLAAFVSVVLGSFLGALAGFIGGWVDGVISRLMDLLLAFPQLLFTIALVSVVPNSVWGFEGSGVRMGVLILVIGFFGWPYIGRIVRGQTISLREREYVEAARSLGAGRGYILVKELMPNLVAPILVYTTLIIPTNILTEAALSFLGAGVKPPTSSWGKMLSDAVPIYQDDPMYMVVPGMTIFITVLAFNLFGDGLRDALDPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J386</accession>
    <name>A0A0F4J386_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_24460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000700">
        <property type="protein sequence ID" value="KJY28817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949741.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000700.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28817">
        <property type="protein sequence ID" value="KJY28817"/>
        <property type="gene ID" value="VR44_24460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.887"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="762" mass="78906" checksum="885E0C9952FEF2AF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J394</accession>
    <name>A0A0F4J394_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000707">
        <property type="protein sequence ID" value="KJY28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949792.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000707.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28715">
        <property type="protein sequence ID" value="KJY28715"/>
        <property type="gene ID" value="VR44_24745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.948"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20305" checksum="8CEC2A52D8B072B7" modified="2015-06-24" version="1">MFSIDLADDAQLFPLEVWHAEEFLAHIDRGREFIGQFIGFPDRATDLESARQLLRSNAEKAAADGRRLYGIRAGGTLVGGVLFADFDAAAGNCEVGCWMEPAGTGRGLVTKACRVLIDWAFDVRGMHRAEWHVAGGNEKSIAVARRLGFTREGVLRQSHLHRGVRQDIEVWSLLADEWAAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3J4</accession>
    <name>A0A0F4J3J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_25745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000746">
        <property type="protein sequence ID" value="KJY28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949978.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000746.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2362"/>
    <dbReference type="EnsemblBacteria" id="KJY28273">
        <property type="protein sequence ID" value="KJY28273"/>
        <property type="gene ID" value="VR44_25745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1254"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="22556" checksum="7451CA3C380FEEDF" modified="2015-06-24" version="1">MACAGGSEAPALPATLKILVAGGFGAGKTTFVGAVSEIEPLCTEELLSGIGEAADPLDGVEAKTATTVALDFGRLTLDDRHVLYLFGTPGQQRFWFLWEELCAGALGAVVLADTRRLADCFPAVDFFERRGIGFVVAVNEFDGGHRYTAEEVREAVGLGPEVPVVRCDARLTGSGTGTLAALVHHLLSTARRTAGPDPATQQHAYAHHFGPGEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J437</accession>
    <name>A0A0F4J437_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000674">
        <property type="protein sequence ID" value="KJY29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29117">
        <property type="protein sequence ID" value="KJY29117"/>
        <property type="gene ID" value="VR44_23675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="38340" checksum="A72410590AB3F422" modified="2015-06-24" version="1" fragment="single">METNSAALVGREEERARLEAFVKSATGQALVLRGEAGVGKSALLDHAAALAAQEGRVVLRAAGVEAESALPYAGLHQFLHPLLSATARPEGDASGAEFDAAFGGTPGQPPSAMALGIAVLRLLMRTRGRRPPLLVLDDGQWLDDASADVCGFVGRRLAGSPVKLLVAVRTDTASRWDTAALPELPVRALSEEDAARLLDRRHPELDRRLRRLVLAQAQGNPLALLELPLQPTGRPGGLPDEDPAGPHGVPLSRRLQRMFDTRIASLDERVRAELLAGALDGAGTPGRADAVPGTRYVMRDADAAVAAGLLDVAPATGELVFRHPLVRSAVVQTATADQRRTAHLALARLHRGDLERRATHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J536</accession>
    <name>A0A0F4J536_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949692.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28919">
        <property type="protein sequence ID" value="KJY28919"/>
        <property type="gene ID" value="VR44_24190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13541" checksum="B76A0AC4DA66CFB0" modified="2015-06-24" version="1">MNRHRGRLRLRLREDRGQVALEYIGFIPILLFVALCGIQLGWIAYVHEQADTAARTAARVEAKHPGRGEAAGRAAIREGLSAQISVPPGGDAITATVTIKINSIVPGLDIPDAKATAVMPNDDPKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5A3</accession>
    <name>A0A0F4J5A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000684">
        <property type="protein sequence ID" value="KJY29009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29009">
        <property type="protein sequence ID" value="KJY29009"/>
        <property type="gene ID" value="VR44_23940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.763"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009334">
        <property type="entry name" value="DUF993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06187">
        <property type="entry name" value="DUF993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25827" checksum="502A008183C99EA7" modified="2015-06-24" version="1" fragment="single">GAVLMASRALAAAARGPEDYLEVYGTLLRQSSRPVVLHWLGPVFDPQLAGYWGHDGLDEAADLLVKIVAEHPRKVDGVKVSLLDAEREKDLRRRLPAGVRCYTGDDHHYPELIAGDGELASDALLGIFDPIAPIAARAALALDREDPGGFRALLDPTVELARHLFAPPTPFYKTGVVLLAWLAGYQEHFTMLAGLESARSLPHLARAYELADQLGLFPDPERAGGRMRRLLAEQGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5D4</accession>
    <name>A0A0F4J5D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiA</name>
        <name evidence="5" type="ORF">VR44_22560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949395.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29562">
        <property type="protein sequence ID" value="KJY29562"/>
        <property type="gene ID" value="VR44_22560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.402"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="32704" checksum="EF4CBC6EF8ACF958" modified="2015-06-24" version="1">MTTTAEGVLGPGQAPRPTGKVKAFLRLVMIEHSVFALPFAYIAALTAMFRLDGRMHWRELLLVTVCMVGLRTFAMAANRIIDRELDARNPRTAGRELVTGAVSVRSAWTGAGIALVVFLGAAALLNPLCLALAPVAVVPMVVYPYGKRFTNFPQAILGLAQAMGPVGAWLAVTGEWSWEAVVLGLAIGVWIGGFDLIYACQDVDSDRAEGVKSVPARFGVPGALWGARACHAVTTALLAAYAVLTDGGAFLWLGLLIVAAAFLYEHTIVKPHDLSRLNRAFFTVNGFIGIALFVCALADLLIRGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6H7</accession>
    <name>A0A0F4J6H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949290.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene889"/>
    <dbReference type="EnsemblBacteria" id="KJY29815">
        <property type="protein sequence ID" value="KJY29815"/>
        <property type="gene ID" value="VR44_21965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.273"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="29089" checksum="481FF6747B0E87FC" modified="2015-06-24" version="1">MEEQNRHPAPHHRPGSPVRSGIPEHGRIPKYYAVKARIAELLDELGEGGVLPTERDLAERYEVARETVRQALRELLLEGRLRRAGRGTVVAGPKLEQPLSLASYTEGVRRQGRRPGRHLIGLERFPCPPELARGIGAETGEPVWHLERVLLADDERVGLESTYVRVARAPRLDVDFQPDSSFYGYLRDSLGISFGDADEKLETVLATPREALLIGTPPALPMLLIHRFSRDQDGLPLERVRSLYRGDRFSFTTRLRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L6</accession>
    <name>A0A0F4J6L6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949181.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2792"/>
    <dbReference type="EnsemblBacteria" id="KJY29997">
        <property type="protein sequence ID" value="KJY29997"/>
        <property type="gene ID" value="VR44_21440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.165"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="35444" checksum="0C456A8FD445E2B5" modified="2015-06-24" version="1">MTPDEALRRIAFLLEWRGASPYRVRAFHTAADAVRDLPAGPVDAAEAARLRGVGPVTAEVISQASTGQVPRYLARLQAEAGPAARAGWDLAAASTGDCHLHSDWSDGGSPLEDMADAARALGHRWAVLTDHSPRLTIAHGLSPDRLRSQLRAVAAVNARLGPGFRLLTGIECDILEDGSLDQDEELLGRLDLVVASVHSKLRSEPGPMTARLLAAVRNPRVDVLGHCTGRIITGRGRPQSRFDAGAVFAACAESGTAVEINCRPERRDPPDDLLELAADAGCRFAVDTDAHAPEQLHWQTTGYARAARIGLGADRLITTWPLGRLLEGRAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J729</accession>
    <name>A0A0F4J729_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_22520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949387.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29578">
        <property type="protein sequence ID" value="KJY29578"/>
        <property type="gene ID" value="VR44_22520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.394"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470788" evidence="4">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="59"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21861" checksum="5E0450F19766DEE3" modified="2015-06-24" version="1">MSLSRATRRRRSTSGRAILLTAVTLASALTLTACGDSGSKSAGSAGGNYVTGPSGISTVAKGDRAEAPRLDGATVDGKTLDTTTLKGKVVVLNVWGSWCPPCRAEAPYFAKVSKELGDAGKDVAFVGINTRDNSTQNAAAFEQNFGITYPSLYDPDGKLILRFPKGTLNPSAIPSTVVLDKEGKIAARTLAAVNEEQLRSMIDPLLAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J753</accession>
    <name>A0A0F4J753_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949771.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28771">
        <property type="protein sequence ID" value="KJY28771"/>
        <property type="gene ID" value="VR44_24615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.918"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="36637" checksum="3F7D0CD231C01F17" modified="2015-06-24" version="1">MSETQDRTQDATRTGSGPGGRHLVAVLALPGFPPFELGIPSRVFGSAVDEDGEALYEVVVCTADGLPVPSDSGFTLQPAAGPEALAAADTVIIPPTHAMPELGRGGPLPPTVAAAIAGIRPGTRLVSICTGSYVLAAAGLLDGRPATTHWNLAREFRRAYPGVRVDEDVLFVDDGDILTSAGVSAGVDLCLHLIRRDHGAAVTNRAARVCVVPPWRDGGQAQYIDRPVPEPTVATTTATRAWALERLAEPVSLAELAAHARMSLRTFTRRFRDEVGMTPVQWLTAQRLEVARDLLESSDLPVDLVAHRAGFGTANSLRQHMRASLGVSPIAYRRTFRAAAPASQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8N4</accession>
    <name>A0A0F4J8N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000540">
        <property type="protein sequence ID" value="KJY30752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948834.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000540.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30752">
        <property type="protein sequence ID" value="KJY30752"/>
        <property type="gene ID" value="VR44_19545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="30074" checksum="CCB7E2D7F8F1763C" modified="2015-06-24" version="1">MPDAAGPHELGALSLYSEVLDADADTLYIRAYYEADQQRAEPWLLAYDLAAHRLRWRTRVAWGYTDRTESLLFRAVVANGRLIGSDATRVFAVDVRDGRFLWVTRLRSDAEAAAPGASGGVHPPVVSEHHVLDVSQVITAVDLLTGTPTWTLKPERDQTLLTSPVCVQGTVHIASHAFTAFEESTGRKLWTYEPGPYFQRIAVPGPFRGELYAAVSGGGQAVIAVDLAQRRASWTLSAQAAGMPDGPSDLTHRDDRLYLQAHQRLTAVRIDTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9S9</accession>
    <name>A0A0F4J9S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948940.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000555.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30559">
        <property type="protein sequence ID" value="KJY30559"/>
        <property type="gene ID" value="VR44_20140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8733"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="23021" checksum="41D6D971F7D820E7" modified="2015-06-24" version="1">MKLEAITWQRMAERLAGHLDAPSAEGGPWRRVGIDGAPAADTGVLAGELADALRQRGRSALVVAAGGFLRPASLRFEFGREDVDAYLGGWYDTGALWREVFAPTDPGGSGRVLPDLWDPVTDRATRSPYTQLPTGGVLIVHGPLLLGHWFPFDLSVHISLSAGALARRTPPSDHWTLPAFARYARETDPASTADALVRADDPRHPAWTGIRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAM0</accession>
    <name>A0A0F4JAM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY30001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949187.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30001">
        <property type="protein sequence ID" value="KJY30001"/>
        <property type="gene ID" value="VR44_21460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.170"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13464" checksum="20129A9DBA43850E" modified="2015-06-24" version="1">MSTGPKSHVPHGEGPSRHEGTEQHGWSPDVDSTHTQDNPSARRSFDTPPKGAPRRTGKVAPSDGAGEVAPVESTSRSGEDLAKGGKQKGHHDLGPRGRSQRPSGGKDDDAYTGVNTREGQGPKKLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAQ4</accession>
    <name>A0A0F4JAQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000534">
        <property type="protein sequence ID" value="KJY30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30838">
        <property type="protein sequence ID" value="KJY30838"/>
        <property type="gene ID" value="VR44_19410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8491"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="5">
        <location>
            <begin position="494"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="595" mass="62616" checksum="7EA98D871CC429D5" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAZ9</accession>
    <name>A0A0F4JAZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000485">
        <property type="protein sequence ID" value="KJY31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000485.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31532">
        <property type="protein sequence ID" value="KJY31532"/>
        <property type="gene ID" value="VR44_17930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8130"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="131"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="35129" checksum="710D43CB2D0D65A2" modified="2015-06-24" version="1">MPEPEPQPYDPVGPGENEAVAPTGQGGAMDLALDEAESLEKPLDPDPSAPRERARSLWSDAWHQLRRNPVFVISSLFILFLVVISLWPQLIASGDPLHCELSKSQQGSSPGHPFGYDTQGCDVYTRTVYGARASITVGICATLGAALLGSALGGLAGFFGGWGDSLLSRVADIFFGIPVVLGGLVFLSVVTSTTVWPVVGFIVLLGWPQLARIARGSVITAKQNDYVQAARALGAGNARILLRHVAPNAVAPVIVVATIALGTYIALEATLSFLGVGLRPPTVSWGIDISNAASQIRNAPHMLLWPALALSLTVLAFIMLGDAVRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBA8</accession>
    <name>A0A0F4JBA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948713.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000518.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31084">
        <property type="protein sequence ID" value="KJY31084"/>
        <property type="gene ID" value="VR44_18890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8318"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="25291" checksum="D855426F3EF17984" modified="2015-06-24" version="1">MRNGEPLRYVALGDSQTEGVGDGDDTAGLRGFADRLAEHLAAAHPGLLYANLAVRGRLAGQVRSGQLGPALELRPDVATVVAGVNDVLRPRFDAAEVAGELEEMFAALTGAGARVATVTFPDVGRIAPLARPLRPRVAELNARVRAAAARHGVVVAETGLAAVGADPRLWSTDRLHASPLGHARIAAALAEALALPGSDDAWRAVAAEVGWAAGFLGPWLGRRLRGTSSGDGRTAKRPQPLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBD1</accession>
    <name>A0A0F4JBD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000517">
        <property type="protein sequence ID" value="KJY31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948711.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31109">
        <property type="protein sequence ID" value="KJY31109"/>
        <property type="gene ID" value="VR44_18885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="140"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="27823" checksum="72FF64D8FDD97BB6" modified="2015-06-24" version="1">MTEAAGASRRPSGTPCWVSLMVHGLGRTEDFYADLFGWEYEPGPAQLGPGVRAVLDGEEVAGIGEMPPDRHLPVAWTTYFAIDDADCAAEAIRSCGGTVAVGPMDAGAEGRVAICSDPLGAIFGIWQDSGHGRRYGLPGTPVWNELVTQDTLTVGKFYQHVFGHEAERHPDAPADFDYLTLRLDGRPVAAVHGVGRSLPHDRGPHWMTYFEVHDTDAAAARVAELGGQVLSPPRDRIRGRLALVADPEGAVFAVVKSAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBK9</accession>
    <name>A0A0F4JBK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948672.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31189">
        <property type="protein sequence ID" value="KJY31189"/>
        <property type="gene ID" value="VR44_18700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8350"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="38190" checksum="E6ED431CA7140A5D" modified="2015-06-24" version="1">MTTHAETAVKYLLGTETTVRLRPRFEGSNINTWIGFKHVNYLVEEAVLAHFRTAGLPSRELFEEHGLGLDVVDLDTRILHAFHQDDEARAVVVPTTRDEDTRFRFSVTLYVERDGKELKAVTSKAEVSLRADDYLAPLAHPEELARFTVERLGDGAGRGPRHGTDVAVADNTALAAGRGTTGADPVLDQLLAGENAFGWKWRIPYPYCHFNERLALSGYLRQVEEVVDLFLADRGISIKTLLDDRKWIPVVPRSQVTFLDEALMEEDLYTVFTVDEVFKDFTYTARTDFYVVRDGRLVQTATGRITHGYAVFENRRDWSLVGFDERVVRALNGDLPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDD6</accession>
    <name>A0A0F4JDD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_19155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000526">
        <property type="protein sequence ID" value="KJY30966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266035.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000526.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5453"/>
    <dbReference type="EnsemblBacteria" id="KJY30966">
        <property type="protein sequence ID" value="KJY30966"/>
        <property type="gene ID" value="VR44_19155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8437"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY30966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="28692" checksum="3B7ED1220DB72C15" modified="2015-06-24" version="1">MATPTLDKMEAAAAASPYITVTFRIRRYNPEVSAEAEWQDFQIEIDPKERVLDGLHKIKWDLDGTLTFRRSCAHGICGSDAMRINGKNRLACKTLIKDINPEKPITVEAIKGLTVMKDLVVDMEPFFQAYRDVMPFLVTKGNEPTRERLQSAEDRERFDDTTKCILCAACTSSCPVFWNDGQYFGPAAIVNAHRFIFDSRDEAGEQRLEILNDKDGVWRCRTTFNCTDACPRGIEVTKAIQEVKRALITRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDY7</accession>
    <name>A0A0F4JDY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1990 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000448">
        <property type="protein sequence ID" value="KJY32014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948343.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000448.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32014">
        <property type="protein sequence ID" value="KJY32014"/>
        <property type="gene ID" value="VR44_16930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7825"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014457">
        <property type="entry name" value="UCP010260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010260">
        <property type="entry name" value="UCP010260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="1">
        <location>
            <begin position="13"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18962" checksum="68F1DF71AF4ECCAB" modified="2015-06-24" version="1">MTRLISTGRRVLSYPERGATLRRPLPDGYHHLHHRAPIGHGREVFEAAGAAVTSFRMHRATGASVRADGPAVPGRRVEIGLGLGPLRITVPCEVVWTPDAPGLAGFAYGTLTGHPESGEESFLVELAPDGTVWFEVTAFSRPASWYTRLAGPLVPVLQRGYARLLGRHLRALAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDY9</accession>
    <name>A0A0F4JDY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_18610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000510">
        <property type="protein sequence ID" value="KJY31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4153"/>
    <dbReference type="EnsemblBacteria" id="KJY31206">
        <property type="protein sequence ID" value="KJY31206"/>
        <property type="gene ID" value="VR44_18610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="16811" checksum="E9EA96210022625D" modified="2015-06-24" version="1" fragment="single">MGRIVVISTGGTIASRWTGSGFAAEAGGREVMATAPLPEGITVEVVDLFSVNSPRLTTAHQLTLLRTVHEVLADPDVDGIVVTHGTDTLEESAFLVDLHHHDPRSVVFTGSQLPMGSTEGDGPGNLYDALLTAATTRGLGVLVAFAGRVHAARGTMKTQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEE9</accession>
    <name>A0A0F4JEE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000396">
        <property type="protein sequence ID" value="KJY32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948033.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000396.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3262"/>
    <dbReference type="EnsemblBacteria" id="KJY32727">
        <property type="protein sequence ID" value="KJY32727"/>
        <property type="gene ID" value="VR44_15305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7463"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="32376" checksum="17E02AC00D26FB11" modified="2015-06-24" version="1">MSSERHDVTDLSTLPTDITRVGVVGCGQMGAGIAEVCARSGLEVKVAETTGEALEIGRTRLHNSLTKAAERGKISEEERDATLARLTFTTDLGEFADRDLVIEAVVENEQVKTEIFQVLDQVITRPDAILASNTSSIPLVKLAVATSRPDQVIGIHFFNPAPVQKLVELIPALTTGEETVKRSEALVRDVLGKHAVRAQDRSGFVVNALLVPYLLSAIRMFESGIASREDIDNGMELGCAHPMGPLKLSDLIGLDTIASIADSMYAEYKEPLYAAPPLLQRMVDAGRLGRKTGSGFYPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF64</accession>
    <name>A0A0F4JF64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000479">
        <property type="protein sequence ID" value="KJY31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948489.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000479.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31621">
        <property type="protein sequence ID" value="KJY31621"/>
        <property type="gene ID" value="VR44_17730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8043"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="29030" checksum="AF2678EE65ADEA64" modified="2015-06-24" version="1">MIDVTRPSYARMYDYLIGGTDNYPSDRRACAELLDIAPDMQQLAQANRAFLVRAVRYLAQTHGVRRFLDFGTGLPTRPNVHEVAQEVTPTASVVYIDNDPMVCAHGRMVLEEDLLTTAVVEADIRDPERIFSVPRVRRILADDRPVAALFVSVLHCLTDDDDPWLLVRDVAARLPAGSYLVISHIASDDATSREELSAFMKRTIGSWGRVRSTADIARFFDGSDLLEHPAPVEVSTWLPDTGLALRPAGADWIACGGVARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFQ7</accession>
    <name>A0A0F4JFQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33025">
        <property type="protein sequence ID" value="KJY33025"/>
        <property type="gene ID" value="VR44_14630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7253"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470901" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="35"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="27303" checksum="416B3418043236AE" modified="2015-06-24" version="1">MRPVVKGAAAAAAAAGIVAAAATVLLGASGEQPVHPFPTVGVLMANGEHWCTASVVDSPKGNVVATAAHCVAPAGEDGRPGETAHDGLAIGELSFAPAFSGEGSGSKPFGVWKVRSIHVDERWTKWGDETADFAFLTVEPDGDGRSLQQRVGQGEAPKPDWTSGYEREVTVIGYPESDHNPQNKPVSCTTQTRHDSDDPDMLYISCAGFWTGTSGSPWIADRGGTGQPGRLIGVLSGGDTDVDSTAALYDERARALYEAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGA0</accession>
    <name>A0A0F4JGA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948346.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene6997"/>
    <dbReference type="EnsemblBacteria" id="KJY31976">
        <property type="protein sequence ID" value="KJY31976"/>
        <property type="gene ID" value="VR44_16945"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="27935" checksum="B18927341698CCE9" modified="2015-06-24" version="1" fragment="single">MSDVLISLDGVEKVFEVRRRSGLMRREKRQVRAVDGISFEVGRGEVVGYIGPNGAGKSTTIKMLTGILTPSGGRLRVAGIDPSRERLRLAHRIGVVFGQRTTLWWDLPLKDSYGLMRRMYRIPAARFRENLDRCVDRLDLAALLDVPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVVSKARVRGFLRQLNEELGTTVLLTTHDLQDIEQLCERVMVIDHGRLMYDGVLGGLHALGEGGERTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGX4</accession>
    <name>A0A0F4JGX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000427">
        <property type="protein sequence ID" value="KJY32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948229.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000427.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32231">
        <property type="protein sequence ID" value="KJY32231"/>
        <property type="gene ID" value="VR44_16330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7723"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="28170" checksum="0D9E44608A5FB33E" modified="2015-06-24" version="1">MAGPEIRQIKSFLATFARRRAARTVELPGGFAALDDEFPLSYGNNHVVIDGAPDPEALPALAEEALGHLSHRLITVLDDTAGEACAEPLLRAGYTRSTYLVMLHRGPVPAGGGAQEVDLDAIRVPLARSWRGSWRGFLPDADEEVIRQLVDRRETVRRGADVVQFIGARTPDGEVASWADLYLDAASGTAQIEDLVTSGLHLRRGYADAVLASALRRAADAHCATRFLIADAQDWPQHWYERRGFTVIGRHHGFERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH79</accession>
    <name>A0A0F4JH79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000418">
        <property type="protein sequence ID" value="KJY32331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948196.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000418.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32331">
        <property type="protein sequence ID" value="KJY32331"/>
        <property type="gene ID" value="VR44_16160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7660"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="25492" checksum="A4A446B0CCECD399" modified="2015-06-24" version="1">MSTPQGRPGGFWRDNSLTLAFGGAFLIVLACQAVAGQAEFNEQLATAGLQQVTFAQYLTSSDFAVDVTENWQSEFLQFFLYIFGTVYLLQRGSPESKKLHKAGPESDRDQHMGEHARADSPRWAGTRDWRQNLYSRSLGTVMALLFLLSWLAQSISGTAAYNAEQLRDLAEPVSWAEYLASADFWSRTLQNWQSELLAVAAMAILSVYLRQRGSPESKPVGAAHSSTGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHV5</accession>
    <name>A0A0F4JHV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyraldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.19" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947664.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene710"/>
    <dbReference type="EnsemblBacteria" id="KJY33790">
        <property type="protein sequence ID" value="KJY33790"/>
        <property type="gene ID" value="VR44_13235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6866"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033737">
        <property type="term" value="F:1-pyrroline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
        <property type="term" value="F:aminobutyraldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="29"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="504" mass="53485" checksum="2F7B5FE85B90EEEF" modified="2015-06-24" version="1">MGNRFQVKDRFADGAQYIDGRLRPGTSGRSHTVVDPATGEEVLTYELAGPADVDEAVAAAKRAFPAWSAATPGERSDALHRLAAVLAEQAEDFAYAESLQCGKPLKLTTGFDVPGTIDNTAFFAGAARHLQGQAAGEYSGDHTSYVRREAIGVVGSIAPWNYPLQMAAWKILPAVAAGNTIVLKPAELTPLTSLMFAQAAQEAGIPDGVINIVTGAGRDAGEHLVGHPDVVMTSFTGSTAVGKRVAEIATATVKRLHLELGGKAPFVVFDDADVEAAAHGAIAASLINTGQDCTAATRAYVQRPLYEAFTARVAELMETVRLGDPFAPTTDLGPLVSHAQRDRVAAFVDRARAYATVVTGGEIPGGDLAEGAYYRPTLITGAAQDSEVVQSEIFGPVLVALPFDTDDEGLALANDTPYGLAASAWTRDLYRAGRATRELKAGCVWVNDHIPIISEMPHGGYKASGFGKDMSSYSFEEYTQVKHVMYDNTAVAAKDWHRTIFGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIH0</accession>
    <name>A0A0F4JIH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33604">
        <property type="protein sequence ID" value="KJY33604"/>
        <property type="gene ID" value="VR44_13680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="31"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="19571" checksum="5D928C5B9EEC4A4C" modified="2015-06-24" version="1" fragment="single">MTTRHEDRGLRSRLRDVPGVRAASSYRREWLVKDLVAGVVLTTLLVPQGMAYAELAGLPAITGLYTTILCLLAYAVFGPSRILVLGPDSSLGPMIAATVLPLVAAGGDPARAVALGSMLAIMVAAVMILASVAKLGFIADLISKPTMIGYMNGLALTILIGQLPKLLGFKVEADSLIGEAVGFVRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIV8</accession>
    <name>A0A0F4JIV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947535.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34120">
        <property type="protein sequence ID" value="KJY34120"/>
        <property type="gene ID" value="VR44_12535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6568"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="39663" checksum="C8B7BB694B95E865" modified="2015-06-24" version="1">MSRIPLGVLDLIPIPSGSSASDALRHSIDLARQTERFGYARYWFAEHHLNPGVAGVSPAVALALTASATSSIRIGSGAVQLGHRTALSTVEEFGLIDALHPGRLDLGLGRSAGAPTPRPAGDEPFVGFTPNGLRIPERFSFAHLLGHPNVALQRKLLNLPGARPQDYAEQVDDVLALLRGEYRSPEGIAARAVPGEGADVEVWILGSSGGQSAETAGRHGLRFAANYHVAPASVLEAAEGYRAAFKPSAELDRPYLSVSADVVVAPDDATARELAAGYAPWVRSIRAAEGAIPFPSPDEARALTAGWSDAEHALVADRVETQFVGSPRTVADHLERLQEATGADELLITTITHDHADRVRSYRLLAEEWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJA8</accession>
    <name>A0A0F4JJA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_14690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947925.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33036">
        <property type="protein sequence ID" value="KJY33036"/>
        <property type="gene ID" value="VR44_14690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7265"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="461" mass="47106" checksum="E18D7BAC4165DA2E" modified="2015-06-24" version="1">MAATVDPGTAAPAALRRSLGFRDLVVYGLLFIAPMAPVGVFGTLDAKSHGAVALVYVVATVAMGCTAFSYAQMVRVAPQAGSVFTYARKGLGEGPGMIAGWMAALDYLLIPAVAYLFSGIAMNALVPQVSRWVWTALAVVVTTLLNLWGVRAAARVGFAVLAVEVVVLLVFLVSAVAVLVRDGARRGWLSPLTGDGSLGFSWAAVVGAVSVAVLSYLGFDAIASFAEEVTGGSARVARALLFCLGLTGVLFVAQTYLAALLAPFSAAELAADPGRQGPAFYTAVEASVGGWLHDLVAVSKAVGAAFAALAGQAAAGRLLFAMARERRLPGVLARTSGGTPRAALLVAAVVTLVAAVWAARRDDGLDHLVSVVDVGALVAFTLLHASVVGWFVVRRAEGPPRWVRHLVVPVLGAAVTVAVIVEASPTAQVVGAVWLAVGLGVLFFQRGRTGAGAGADTLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK28</accession>
    <name>A0A0F4JK28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methlyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947533.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000028_gene2076"/>
    <dbReference type="EnsemblBacteria" id="KJY34118">
        <property type="protein sequence ID" value="KJY34118"/>
        <property type="gene ID" value="VR44_12525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6566"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="32059" checksum="733EAF29CFFCA3D7" modified="2015-06-24" version="1">MTSTVSTTPFIPAPATPYQGDIARYWNEEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDTADSEYEKKLVAELHRLESAQAELLLDHLGAIGRDDMLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAKQADFGNNRARELGIEESVHSRVCNMLDMPFETGQAAGSWNNESSMYVDLHDLMAEHSRVLAVGGRYVTITGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQAVIDLTPDTLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLC7</accession>
    <name>A0A0F4JLC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000279">
        <property type="protein sequence ID" value="KJY34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947362.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000279.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34568">
        <property type="protein sequence ID" value="KJY34568"/>
        <property type="gene ID" value="VR44_11625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6291"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="24154" checksum="3C7910BB68E61D8C" modified="2015-06-24" version="1">MNGNTVALVTGGSRGIGAATALRLAEDGFDVALTYVDGAQAAAEVAGKIEALGRRALAVRADAGAADGPRTAVEETVRALGRLDVLVNNAGAGVLGPIGSLGAADVDRVLAVNVRGAFLAAQAAAGHMGSGGRIVTIGSCMVQRVPGPGGTLYAMSKAAMTGLTKSLARELGGRGITANLVHPGPTDTDMNPADGPYADPQRSMTALGRYGTPQEVAAMVSFLAGPDAAYVTGAEFSVDGGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLW9</accession>
    <name>A0A0F4JLW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000326">
        <property type="protein sequence ID" value="KJY33926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33926">
        <property type="protein sequence ID" value="KJY33926"/>
        <property type="gene ID" value="VR44_12945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6706"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="43" mass="4469" checksum="418C4BBB95B556FF" modified="2015-06-24" version="1" fragment="single">MKTPADETEARAIQDELRKSVVLDEPGPAPGSGLVAGVDVAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMW6</accession>
    <name>A0A0F4JMW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000215">
        <property type="protein sequence ID" value="KJY35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000215.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35530">
        <property type="protein sequence ID" value="KJY35530"/>
        <property type="gene ID" value="VR44_09985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5544"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8492" checksum="93687FABEDD6BF8F" modified="2015-06-24" version="1">MHAFTHDRIHAARTAELAAEAAAWHLAHEAATATATEAAPAALPARPTLRNRLGKTLVAAGIRLMQPEHLHARPQRHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNG0</accession>
    <name>A0A0F4JNG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000232">
        <property type="protein sequence ID" value="KJY35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947141.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35293">
        <property type="protein sequence ID" value="KJY35293"/>
        <property type="gene ID" value="VR44_10430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5828"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8002" checksum="2E63271195450263" modified="2015-06-24" version="1">MRTTIGYTIESIGYVVGAQGLISFGSQAFFGTEWGWMHKVVGLPTSAYLGVFAVGLVLVAIGVRTRKGPARRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNP3</accession>
    <name>A0A0F4JNP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000281">
        <property type="protein sequence ID" value="KJY34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947369.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000281.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3708"/>
    <dbReference type="EnsemblBacteria" id="KJY34546">
        <property type="protein sequence ID" value="KJY34546"/>
        <property type="gene ID" value="VR44_11660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6298"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21836" checksum="2426D278C4FA6BE7" modified="2015-06-24" version="1">MTIRLLLADDHPVVRAGLRAVLDTEPDFAVVAEAATAERAVELAASEPVDVVLMDLQFGAGMHGSAATAAITARPGAPRVLVLTTYDTDADILAAVEAGASGYLLKDAPPEELAAAVRTAAAGQSALAPAVALRLMDRMRTPAEALTKRELEVLQLVADGLSNQQISKRLFLSQATVKSHLVHVYAKLGVDSRTAAVAAAATRRLIRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPL2</accession>
    <name>A0A0F4JPL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_08490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946780.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene934"/>
    <dbReference type="EnsemblBacteria" id="KJY36120">
        <property type="protein sequence ID" value="KJY36120"/>
        <property type="gene ID" value="VR44_08490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4761"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="341"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="454" mass="49465" checksum="F107B5C8797A6FC6" modified="2015-06-24" version="1">MSVSTEIEKNGTSPEKLLAPVLSAFWDEPESWTLETYRRHEGYEGLRKALAMTPDEVIAYVKDSGLRGRGGAGFPTGMKWQFIPQGDGKPHYLVVNADESEPGTCKDIPLLFANPHSLVEGMIIACYAIRSEHAFIYLRGETVPVLRRLHEAVREAYAAGYLGKDIDGSGRNLDITVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVEGLYACPTVVNNVESIASVPAILNKGKDWFKAMGTEKSPGFTLYSLSGHVAGPGQYEAPLGITLRQLLDMSGGMRPGHRLKFWTPGGSSTPMFTDEHLDVPLDYEGVGAAGSMLGTKALQCFDETTCVVRAVTRWTEFYAHESCGKCTPCREGTYWLVQLLRDIEAGKGVMSDLDKLNDIADNINGKSFCALGDGAASPIFSSLKYFRAEYEQHITGKGCPFDHRKSTLWADGPAENSEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQN1</accession>
    <name>A0A0F4JQN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trehalose 6-phosphate phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_08675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946816.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36058">
        <property type="protein sequence ID" value="KJY36058"/>
        <property type="gene ID" value="VR44_08675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4979"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="316"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="612"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="799" mass="88573" checksum="255DEECC822A067A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQQ0</accession>
    <name>A0A0F4JQQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000173">
        <property type="protein sequence ID" value="KJY36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36179">
        <property type="protein sequence ID" value="KJY36179"/>
        <property type="gene ID" value="VR44_08410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4581"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="349" mass="36904" checksum="A8E555C0F50F185D" modified="2015-06-24" version="1">MAQAYLTETGNGGSEPGPSGSGLRRRWAALLRRLAELRRDPGIWKRGIVTAAFALLISGIMVFHAELPNDVGNLGSLTETFLPWLGVFVPVLLAIAVARRSATALIAILLTAAVWVNLFGGLVTDKSGGGGNLMVATHNVDADNPDPRGTARSVAKSGADVLALTELKAGAVPIYEEALAGTYKYHAVEGTVGVWSKYPLTSSKPVDIRLGWTRAMRTTVAGPFGELGVYIAHLPSVRVKLNAGFTANQRDNSADALGAALAAEPLKNVVLLGDLNGTMNDRSLSEVTSQMRSTQGAAGNGFGFSWPAQFPMARIDQIMVRGVKPEASWTLPRTGSDHLPVAARLTVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR27</accession>
    <name>A0A0F4JR27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946599.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36635">
        <property type="protein sequence ID" value="KJY36635"/>
        <property type="gene ID" value="VR44_07535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3984"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="30389" checksum="F42D87C93E81D128" modified="2015-06-24" version="1">MSARRSLEGQVAVVTGAARGVGELLARKLSARGAKVALVGLEPEALKEVSERLHTDSDHWFADVTDHEAMARVAQEVKQRFGKVDIVVANAGVASGGPFVDSDPEAWRRVIEVNLIGGAVTARAFLPVLMESRGYFLQIASLAAITPAPMMTAYCASKAGVEAFAHCLRAEVGYKGVKVGVGYLSWTDTDMVRGADQHDVMRELRGRLPWPANRTYPLGPAVDRIVAGIERRSAHVYAQWWLRGTQGVRGYLPAVIAAGGQRPKGLVGAGGAADEQERAQNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRR4</accession>
    <name>A0A0F4JRR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36438">
        <property type="protein sequence ID" value="KJY36438"/>
        <property type="gene ID" value="VR44_07965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4416"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9144" checksum="5FA1FC61AB532D41" modified="2015-06-24" version="1">MNPAVPAARPGRRRTTTPADAGRAAGQGLRLYEITYLGTGPEPEVRTVEAGEVAAVIEHAGEHGVQVLVRPCRGQVGEPSTRKEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS0</accession>
    <name>A0A0F4JRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947007.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35641">
        <property type="protein sequence ID" value="KJY35641"/>
        <property type="gene ID" value="VR44_09640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5376"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="627" mass="68360" checksum="8189C8CD7B1D7232" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS1</accession>
    <name>A0A0F4JRS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000122">
        <property type="protein sequence ID" value="KJY37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946439.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37057">
        <property type="protein sequence ID" value="KJY37057"/>
        <property type="gene ID" value="VR44_06630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3244"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21601" checksum="644938B942BC7832" modified="2015-06-24" version="1" fragment="single">YRAYTVRDAVLLARVRRLTELGLSLDEVRDVLADDAGRELADVLAELDADLARQEAALAERRRRLAVLLAAGPGEGEPVSPALAALLAKAPPTDSPAAAKDREHLTLLDATGAVGEGLYAVLGPLAADPDVLALYERLDELADAPADDPRIGPLAEAMVAAVPAAAFDAIPSAGPVVPGFGEALLAEYAPAQAEVVRRVMAAFVGRGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSD1</accession>
    <name>A0A0F4JSD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000142">
        <property type="protein sequence ID" value="KJY36739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946552.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2228"/>
    <dbReference type="EnsemblBacteria" id="KJY36739">
        <property type="protein sequence ID" value="KJY36739"/>
        <property type="gene ID" value="VR44_07290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3929"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="81"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="28231" checksum="429F5326B900BA62" modified="2015-06-24" version="1">MPADTDTAPAAVTAAARRTASPWVLMYHSVAEFTDPAEDPYGITVTPGALEAQLLWLRSRGLRGVSVGELLRARAAGRGHGLVGLTFDDGYTDFLTRALPLLRRHDFTATLFVLPGRLGVDNVWDPLGPRKSLLTAEQIREVAAAGQEIGSHGLLHQDLTAAPDDVLQQELRGSRELLRELTGTLPEGFCYPYGHLDARVVDATRAAGYGYACAISPGRLAGRHALPRTHVSQADGAARLRIKELRHGVRELRRKVPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSG6</accession>
    <name>A0A0F4JSG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_05950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946308.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37312">
        <property type="protein sequence ID" value="KJY37312"/>
        <property type="gene ID" value="VR44_05950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2404"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="18833" checksum="28296A2B4D4E585D" modified="2015-06-24" version="1">MSTASVSVRPGAVLADLLPASRVRDIALVVGGAALTGLAAQISVPVPGSPVPVTGQTFAALLVGTAFGARRGFLALGLYAALGAAGLPWFAAGTSGAGGASFGYVLGMLLAATVVGALARRGADRSVLRTAGTMVLGSAVIYAVGVPYLMAATGMSLTAALAAGLTPFLIGDALKAALAMGALPAAWKLAGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSL0</accession>
    <name>A0A0F4JSL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946857.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35916">
        <property type="protein sequence ID" value="KJY35916"/>
        <property type="gene ID" value="VR44_08895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4948"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="17512" checksum="9E2254207740B99B" modified="2015-06-24" version="1">MTIKDIGPEPQSFDLERATLENTDYRSVAWSGKYLQLTLMSIPVGEDIGLEAHPETDQFLRLDAGRGRVQMGSAKDRLDFDREVEDGWAVFVPAGTWHNVTNIGDEPLQLYAVYAPVHHAPDKVHATFADAERDEAAGGDEPPSWSVQPARQVSDEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSR6</accession>
    <name>A0A0F4JSR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946361.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000116.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene77"/>
    <dbReference type="EnsemblBacteria" id="KJY37220">
        <property type="protein sequence ID" value="KJY37220"/>
        <property type="gene ID" value="VR44_06245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3003"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25137" checksum="9D675AE8DE9610DF" modified="2015-06-24" version="1">MSRSVLVTGGNRGIGLAIARAFAQAGDKVAITYRSGEPPQELADLGVLAVRCDITDSEQVEQAYKEIEAKHGNVEVLVANAGITKDTLLMRMSEEDFTSVVDTNLTGTFRVVKRANRGMLRAKKGRVVLISSVVGLLGAAGQANYAASKAALVGFARSLARELGSRNITFNVVAPGFVDTDMTKVLSDEQRADILAQVPLARYAQPEEIAAAVSFLASDDAAYITGAVIPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTC8</accession>
    <name>A0A0F4JTC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_05615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946246.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2509"/>
    <dbReference type="EnsemblBacteria" id="KJY37415">
        <property type="protein sequence ID" value="KJY37415"/>
        <property type="gene ID" value="VR44_05615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1936"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="423"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="537"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="902" mass="97788" checksum="BCB660FCBBD14090" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUC1</accession>
    <name>A0A0F4JUC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000093">
        <property type="protein sequence ID" value="KJY37775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946132.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene178"/>
    <dbReference type="EnsemblBacteria" id="KJY37775">
        <property type="protein sequence ID" value="KJY37775"/>
        <property type="gene ID" value="VR44_04990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1313"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="32571" checksum="FDEFEB842C6EB62B" modified="2015-06-24" version="1">MGRAGLVTAEASGSVVRRILLGSQLRRLRESRGITREAAGYSIRASESKISRLELGRVSFKARDVEDLLTLYGVTDGTERESLLGLVREANAAGWWHSYGDVLPGWFQTYIGLEGAASLIRIYEVQFVHGLLQTEAYAQAVVKRGMPNASAAEIDRRVALRLERQKVLVSENAPVFHAVLDEAALRRPYGDRDVMRGQLEHLIEISQRPNVQLQVMPFSFGGHAGESGAFTLLRFPESDLQDIVYLEQLTSALYLDKEEEVGQYARAMERLQADCPDPDQTRDLLRGLLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUK0</accession>
    <name>A0A0F4JUK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946249.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37418">
        <property type="protein sequence ID" value="KJY37418"/>
        <property type="gene ID" value="VR44_05635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1942"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041478">
        <property type="entry name" value="TetR_C_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17935">
        <property type="entry name" value="TetR_C_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21174" checksum="A8A412D382CB2D01" modified="2015-06-24" version="1">MPSAAAEPLTPERILETTEEVLRRFGPTKATVVDVARALGVSHGSVYRHFPSKAALREAVTDRWLAKSVVMLEGIASAPGEAAPSKLESWLEALFEAKRHKAGDDPELFATYTVLLAENSGVVDTHLTELIDQLTRIIAEGVAAGTLAAPDVPAAARAVFDATGRFHDPQYVAEWFSPTITTEFEAVVALVIRGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV57</accession>
    <name>A0A0F4JV57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38247">
        <property type="protein sequence ID" value="KJY38247"/>
        <property type="gene ID" value="VR44_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6402" checksum="0C48397EF58877EF" modified="2015-06-24" version="1" fragment="single">MLEPGEEHGGRWLRELGAVALMRLLTGPDPGPGPLTGAGPERIAGYRRRAALAEPARDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVL2</accession>
    <name>A0A0F4JVL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000092">
        <property type="protein sequence ID" value="KJY37788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37788">
        <property type="protein sequence ID" value="KJY37788"/>
        <property type="gene ID" value="VR44_04970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1309"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="22897" checksum="ACB095475183D0CF" modified="2015-06-24" version="1" fragment="single">MGWLRALKGTARTAMTVERQRLEPLVALRAAVGLALVIGAGLAFLGPGAAASSAFGAFMAAVATFQQSWRPRPVLALASGLTLAVSTFLGYLVGSADIGLFLPMLALWSFGAGLLWAAGPTAGMIASGNVAIMLVTVTLPTSVPQAAGHAAMIAAGGVVQALLIVLFPVRRWGAQRDALADALAAEADYARRLRHDPVSAFDPVPLMKARDAAAVTARQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWD2</accession>
    <name>A0A0F4JWD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000075">
        <property type="protein sequence ID" value="KJY38154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945964.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000075.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38154">
        <property type="protein sequence ID" value="KJY38154"/>
        <property type="gene ID" value="VR44_04080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8721"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471106" evidence="1">
        <location>
            <begin position="24"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="38995" checksum="52429E4989CF1792" modified="2015-06-24" version="1">MSTTKKIAGAALAAALGVSTLAACGGGTKKDDGAAASGSPKSKTVTLVSHDSFNVSEPVLKEFEQQSGYTVKVLKSGDAGAALNQEILTKGSPRGDVFFGVDNTLLSRALDNGIFTPYEAKGLDGVKPEYVLDKQHRVTPVDSGDICVNYDKAYFADKKIAPPQTLDDLVKPEYKNLLVTENAATSSPGLGFLLASVGKYGEDGWKDYWSKLKANGVEVVDGWEQAYNERFSGSAGGKKAKGDRPLVVSYASSPPVEVLYGEPQPAEAPTGVATGTCFRQVEFAGLLKGAKNEEGGKALIDFLIGKKFQEDMPLQMFVNPVVKDAKLPEVFTKHGAVVEKPENVAPETIAKNRDQWVKAWSSIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWY7</accession>
    <name>A0A0F4JWY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945802.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38650">
        <property type="protein sequence ID" value="KJY38650"/>
        <property type="gene ID" value="VR44_03135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7842"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="18399" checksum="3A21EA522468A39C" modified="2015-06-24" version="1">MDNDWRHDRIGSAHRGQNPTVLRRLDAGFAAIGDRQFLPGYSVLLADDPAVTRLSDLTPARRTAYLTDLERFAEAVERACARLDPAFRRVNIEILGNTDPYLHAHIWPRYDWEPADLVRMPVWLYRDEEYWRGDRHALAPRHDAVRAAITEELDRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXI2</accession>
    <name>A0A0F4JXI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000034">
        <property type="protein sequence ID" value="KJY39082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945635.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39082">
        <property type="protein sequence ID" value="KJY39082"/>
        <property type="gene ID" value="VR44_02260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470945" evidence="2">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12074" checksum="642ADC78A0CA1F8E" modified="2015-06-24" version="1">MSGARYARTVLARALTVACVALLCLFAAGPAASATAGADPRAASSAPADPAEGQGQGQSGPASDPDARADVRTVVRAAPALRELPPGTFHVKHAGESTCVAQGGPDGAALSPRTVRSVVLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY40</accession>
    <name>A0A0F4JY40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945665.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39040">
        <property type="protein sequence ID" value="KJY39040"/>
        <property type="gene ID" value="VR44_02470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6784"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="3">
        <location>
            <begin position="493"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="604" mass="63637" checksum="2691F8CB5695D4EA" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYD1</accession>
    <name>A0A0F4JYD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946036.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000060_gene2707"/>
    <dbReference type="EnsemblBacteria" id="KJY37981">
        <property type="protein sequence ID" value="KJY37981"/>
        <property type="gene ID" value="VR44_04480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.703"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="201"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="459" mass="49672" checksum="697D89154E6114BD" modified="2015-06-24" version="1">MTSRSSRVTARPSSEGRAVARTQTLLKGENGIGTVRRTVLPGGLRVVTETLPSVRSATFGIWANVGSRDETPSLNGATHYLEHLLFKGTAKRTALDISSAIDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIREEDVDAERGVILEEIAMTEDDPGDMVHDLFAQTMYGDSPLGRPVLGTVDTINALGADRIRRFWKKHYDPTRLVVAAAGNVDHAKVVRQVRAAFEKAGALGNTDARPLGPRTGSKRIRTAGRVDLVNRKTEQAHVVLGMPGLSRTDDRRWALGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADTGLFGVYAGCRPSQVHDVLRICRAELDKVASEGLTDEEIRRAVGQLSGSTVLGLEDTGAIMNRIGKSELCWGDQMSVDEMLARISEVTPDDVREVAQDVLAQRPSLAVVGPLKEKQAARLDEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYD4</accession>
    <name>A0A0F4JYD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000045">
        <property type="protein sequence ID" value="KJY38859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38859">
        <property type="protein sequence ID" value="KJY38859"/>
        <property type="gene ID" value="VR44_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ_C" evidence="2">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="11090" checksum="120A9DCD8CC4AE56" modified="2015-06-24" version="1" fragment="single">GGGFDGGFDVGGPGGGFGGTDFEDLLSGLFGRGGERGGFGRTPGTDQVAEITLQVEDAYAGGRRRVTLDTGAGPRSYELNVPPGVTDGQRIRLAGEGGAGSGGGPAGDLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZQ9</accession>
    <name>A0A0F4JZQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945390.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4757"/>
    <dbReference type="EnsemblBacteria" id="KJY39610">
        <property type="protein sequence ID" value="KJY39610"/>
        <property type="gene ID" value="VR44_00940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2900"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="39439" checksum="B5D96ADED09D3578" modified="2015-06-24" version="1">MGSVRVAIVGVGNCAASLVQGVEYYKDADPATKVPGLMHVQFGDYHVGDVEFVAAFDVDAKKVGLDLSDAIGASENNTIKICDVPNKGVTVQRGHTLDGLGKYYRMTIEESSEAPVDVVQILKDRQVDVLVCYLPVGSEDAAKFYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVRLERTMQLNVGGNMDFKNMLERDRLESKKISKTQAVTSQIPDRELGEKNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDALRAAKIAKDRGIGGPILSASSYFMKSPPVQYFDDEALANVEKFIKGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZY5</accession>
    <name>A0A0F4JZY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">VR44_00825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945369.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4779"/>
    <dbReference type="EnsemblBacteria" id="KJY39715">
        <property type="protein sequence ID" value="KJY39715"/>
        <property type="gene ID" value="VR44_00825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2870"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="452"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="673" mass="74244" checksum="57CC98D861AE1E47" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6K7</accession>
    <name>A0A0F4I6K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001693">
        <property type="protein sequence ID" value="KJY17088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17088">
        <property type="protein sequence ID" value="KJY17088"/>
        <property type="gene ID" value="VR44_40150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="10578" checksum="DEF1446EE797F8EE" modified="2015-06-24" version="1" fragment="single">PVAAGLTRELREALTARGATVTTLTVDPAEDRAALAGRLQEAAAGAAPRTVVSLLALDGRPAAGPAAPGSGDAATLTLIQALGDAGVEAPLWCATRGAVTTSPQDPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7V1</accession>
    <name>A0A0F4I7V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_40285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001714">
        <property type="protein sequence ID" value="KJY16806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16806">
        <property type="protein sequence ID" value="KJY16806"/>
        <property type="gene ID" value="VR44_40285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="125"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY16806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="28729" checksum="7F4125094AFFD950" modified="2015-06-24" version="1" fragment="single">CAGLPATSLAWGPWAGSGMAATPEVADGLRKRGLEPLDAEAALTVLDRAVGRGATAVTVADVDWARFAPTFTIGRPSPLLAALPEVRDAANGRPASSGGAGGGAEDTARALRRTLAQADPADRDRTLVELVRREAAAVLGHPDPEAVEPGRAFRDLGFDSLTAVELRGRLVHATGLDLPTTLVFDHPCALDLAGRLLAELLGTTEPSTAAATRAPADEDPVAIVAMSCRYPGGVRSPEELWRLVEEGTDAMSVFPDNRGWDLDALYHPDPDHPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAT6</accession>
    <name>A0A0F4IAT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NPCBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001566">
        <property type="protein sequence ID" value="KJY19140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19140">
        <property type="protein sequence ID" value="KJY19140"/>
        <property type="gene ID" value="VR44_39225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5647"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPCBM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="10892" checksum="5CB13142F7B18B5E" modified="2015-06-24" version="1" fragment="single">FGQGITVNSRSSVEITLNRQCTSFSARAGVDGLSLLTDGTVRFSVYADGQRLWRSDPLGYGDAPAAVQVPLAGRSTLRLVVEQAGQGHLPTLASWADAVISCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICI6</accession>
    <name>A0A0F4ICI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001608">
        <property type="protein sequence ID" value="KJY18376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18376">
        <property type="protein sequence ID" value="KJY18376"/>
        <property type="gene ID" value="VR44_39585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6030"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="611" mass="57013" checksum="846EB3C34AFEAF59" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IF64</accession>
    <name>A0A0F4IF64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001509">
        <property type="protein sequence ID" value="KJY20314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20314">
        <property type="protein sequence ID" value="KJY20314"/>
        <property type="gene ID" value="VR44_38720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="11547" checksum="A35E0703C3E4C1E4" modified="2015-06-24" version="1" fragment="single">MPARASNQGRPQSKGGTAGTQRPTGRGIGPGLRQRAIRAGIALSVARETDVRHGLVVTVHLTGFAAACPRSISILLAIAGVFTAAGILAIAGLFTVARVFTVARVFTFPGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFT2</accession>
    <name>A0A0F4IFT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001482">
        <property type="protein sequence ID" value="KJY20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952338.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001482.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20877">
        <property type="protein sequence ID" value="KJY20877"/>
        <property type="gene ID" value="VR44_38525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5356"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="34886" checksum="B34A99E1D94C226F" modified="2015-06-24" version="1">MGTATRVPQRQDPAVASAARAVEGEELSAEEAVAALRRHGGWSLVRDSFIRFRYADGFSHSRALALQTVLAIVPLAIALIGLSGALHTEAVGRIAELTIRRLAGGPSRDVVDEALAQSRQRSGEGSQAALWFGLLFSVVNVTTALCQVERGANRIYGNERDRPFLHKYARGLVMSVLAGLPLGLSFCVTVLGAHLSRAVAEVYHLGPGPVHTWDLLRWPVGVLLALLATSAIFRLAPRRRQPGYTWLAFGAGVYLTLWLLATWGLSLYVGDGGSFTTVYGPLSAFVSLLLWSYLTSTALFLGLAFAAQLEAVRAGVSEPVTPDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQT8</accession>
    <name>A0A0F4IQT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001345">
        <property type="protein sequence ID" value="KJY23858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23858">
        <property type="protein sequence ID" value="KJY23858"/>
        <property type="gene ID" value="VR44_37040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470323" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="34" mass="3104" checksum="EB441104558E15E3" modified="2015-06-24" version="1" fragment="single">MLKKMMVTAAATAAAIGAGAAAAAPAMAIGNDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRJ2</accession>
    <name>A0A0F4IRJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001294">
        <property type="protein sequence ID" value="KJY24093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951928.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001294.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24093">
        <property type="protein sequence ID" value="KJY24093"/>
        <property type="gene ID" value="VR44_36330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4517"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7974" checksum="BA30E69C186AC9D6" modified="2015-06-24" version="1">MGRAQGFSYGVHGDGTVVITHRGRAAGTLRGGRAAKFLAEVESGDAQLVMARWTGSYKFGNERTARDHPRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IST8</accession>
    <name>A0A0F4IST8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001127">
        <property type="protein sequence ID" value="KJY25057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951424.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001127.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25057">
        <property type="protein sequence ID" value="KJY25057"/>
        <property type="gene ID" value="VR44_33590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3600"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="34942" checksum="43E73E2C7528031F" modified="2015-06-24" version="1">MEITAGGLLEIRITPADVGKRVSVRRVREGTGGTPAFTDAVGVLTSWTGGVLTITRKDGVSVHIPESSLVAGKVVPAAPARRRGPAASFEELARVMARAWQPLESEPLGDWTLRAAGGFTRRANSVLALGDPGIPLDEALARVTAWYADRDLPAYVQASTGAAGTQELLCAELERRGWVNEVSAEVRTAGLAPVADLDADVSGIRLTREPDEEWLGRYGKVRDPELARRVLVEGPSVWFASLDGGRAVGRCVVDGRWAGFGAVTVAPEHRRRGLATAVMTALARRALEEGASAAWLQVETDNPAARALYDGMGFAAHHAYHHFRAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT07</accession>
    <name>A0A0F4IT07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001349">
        <property type="protein sequence ID" value="KJY23841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952074.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001349.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23841">
        <property type="protein sequence ID" value="KJY23841"/>
        <property type="gene ID" value="VR44_37090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4806"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469772" evidence="1">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14581" checksum="CFA31EE0BEEB0AA1" modified="2015-06-24" version="1">MLCAAAALAALAAPASAQSAPADPYPVVVVDCFSAAQVQPEEYILACGDGNNRLVGLHWHTWGAGTATATGTDMVNDCRPYCAAGHFRPYPVEVTLSAPRPWPTHPGVQRFTVIRLLYTDTAPEPVHKDVTYKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT25</accession>
    <name>A0A0F4IT25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobinamide adenolsyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001115">
        <property type="protein sequence ID" value="KJY25147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951365.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001115.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene34"/>
    <dbReference type="EnsemblBacteria" id="KJY25147">
        <property type="protein sequence ID" value="KJY25147"/>
        <property type="gene ID" value="VR44_33280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3532"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="22296" checksum="FF9DB531FF75B188" modified="2015-06-24" version="1">MPQGQPTVVPDDGLTTRQRRNRPLVFVHTGPGKGKSTAAFGLALRAWNQGWPIGVFQFVKSAKWKVGEENALKVLGASGEGGSVVWHKMGEGWSWVQRDAQLDNEQAAKEGWEQVKRDLAAETHKLYVLDEFAYPMHWGWIDVDEVIEVLRSRPGTQHVVITGRNAPEKLMEFADLVTEMTKVKHPMDAGQKGQKGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU10</accession>
    <name>A0A0F4IU10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001275">
        <property type="protein sequence ID" value="KJY24176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951890.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001275.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24176">
        <property type="protein sequence ID" value="KJY24176"/>
        <property type="gene ID" value="VR44_36125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4466"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28171" checksum="1A17CB6B2278C29B" modified="2015-06-24" version="1">MILTWLYAPGDRPAVVEKALRCGADAVIVDLEDSVSASRKEYARAATAELLTERPPVPVHVRVNALGSPWAGADLTALARLHGLAGLRLPKVDAPEQIVRVADRTGGVALYALLESALGVERAYEIARAHPSLQGLTLGEADLCADLGVCAEGGLDWPRSRVVVAARAAGLAPPAQSVFPDIRDLEALAASCARGRSLGFLGRAAIHPRQLPVIERAFLPGPEEVTAAEEIVSAARAAPGALALPDGRFVDPAVVAAAHRTLSLARRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU46</accession>
    <name>A0A0F4IU46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951176.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25527">
        <property type="protein sequence ID" value="KJY25527"/>
        <property type="gene ID" value="VR44_32255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3173"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18494" checksum="ABD7E9A79CFF33FA" modified="2015-06-24" version="1">MTEQPTTEQRGATLRDEDFLRLDGQICFALGAANRAFGGLYRVILKDLELTYPQYLVMLVLWEHGTMPVKQLGQHLRLDSGTLSPLLKRLEAAGLIRRERSTEDERSVHAVLTEEGAALRERAVEVPRRIARATGFELAEIRELQERLGRLTAALDAAVDSVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX2</accession>
    <name>A0A0F4IUX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001020">
        <property type="protein sequence ID" value="KJY25830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25830">
        <property type="protein sequence ID" value="KJY25830"/>
        <property type="gene ID" value="VR44_31505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11612" checksum="B51F907E2A5E974D" modified="2015-06-24" version="1" fragment="single">MCRWLAYSGSPLLLDAVLYRPEHSLINQSLRARLGVETTNGDGFGVGWYSPDGDGTPAVFRDTAPAWNNRNLRELAAHVRSPLFFAHVRASTGSAVQQTNCHPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXY2</accession>
    <name>A0A0F4IXY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase PA-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000953">
        <property type="protein sequence ID" value="KJY26323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950813.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000953.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26323">
        <property type="protein sequence ID" value="KJY26323"/>
        <property type="gene ID" value="VR44_30280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2466"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470237" evidence="1">
        <location>
            <begin position="33"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="289"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="424" mass="44338" checksum="6E0A6DC6DF8C38CF" modified="2015-06-24" version="1">MPLPSPSRVRPALLAAGCAALLALTVSVPSAAAPVRPEPAGAGSVVLDWYDTTARTVAATAAPAQITNSRTWAVGWIAAARAAREAPGGGPSRGRFQDAAVASAVHDVLVALAPSRKDDLDRALASSLSGIPDGPAEDRGVAAGARQARAVLAARAGDGLDPASSNTPFPVAPAAPGIWQPTPDGYAPAIQYGNRLARPFLLERADQFRLGPPPALDSDRYRADLEEVRAYGAADSAVRSPRQTETANFWYSGSLTLYTDVLRVAVARSHGSTADRAALLALFHAASVDTQIATSDSKYTYVRWRPVTAIRTGSIGTDPAWRPLHNTPAHPDYPSGHATYAGAAQAVLDALAGPVTETFDLTSPTAPGVHRAYSGWAQLTRDNVDARVYSGIHSRTADEAGARLGETVGRYALRHADRLLSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYT7</accession>
    <name>A0A0F4IYT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000900">
        <property type="protein sequence ID" value="KJY26824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950604.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000900.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26824">
        <property type="protein sequence ID" value="KJY26824"/>
        <property type="gene ID" value="VR44_29135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2168"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13907" checksum="35650335B1D6B0E1" modified="2015-06-24" version="1">MTRTRRNLWLHKGNYRRLADGDTFLTPSQLLELLLTGYIEGHIGVTVPERASRAPGRGRVVVALDDDVFARVEAGAGEGRTSLVIDTLIEAYLAGGITITLHATTDATQRAATLTVEPVEPPAENDAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ88</accession>
    <name>A0A0F4IZ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroloquinoline quinone biosynthesis protein PqqE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_27830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000846">
        <property type="protein sequence ID" value="KJY27345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27345">
        <property type="protein sequence ID" value="KJY27345"/>
        <property type="gene ID" value="VR44_27830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="43068" checksum="2DFB4B08FC28A687" modified="2015-06-24" version="1">MGAGLVRPATLVRRPRHSVSERPFLVIWEATRACPLACLHCRAEAATARHPEELDGAWARRVMDQVAAFGRPAPLFVITGGDPFQRPDLTELIAYGTGLGLRVAVSPSGTPTLTPESLRAVRDAGAVAVSLSLDGSTAARHDAFRGVPGVFERTLEGWWAARALGLKVQINTTVSRDSLEDLADIAALVRREGAVLWSAFLLVPTGRGQRLDPLTPEAIEDVLHFLHDCGAVLPVKTTEGHHFRRVALQRAVLDARGEPPALGPLYGRLRARAASARLFEGERRPVRRAPLDVSSGRGFAFVSHTGEVHPSGFLPVPAGNVKNRPLTEIYRGSPLFTALRDTSLLGGRCGACEFKPVCGGSRARAYGTTGDVLGEDPYCAYEPGSFPYQAELRPLTERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZG8</accession>
    <name>A0A0F4IZG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SUKH-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000894">
        <property type="protein sequence ID" value="KJY26883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26883">
        <property type="protein sequence ID" value="KJY26883"/>
        <property type="gene ID" value="VR44_29000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2133"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15788" checksum="47FDE2E0C8BE5B97" modified="2015-06-24" version="1">MRTAGWEPGRWDIKQAEYWADALRDHTTPAGHRHTVFPAAVEAWAEFGGLTVTAPGPGRQIAPTPVRLDPLTGLHLARTFADLGRALSTQLCPLGSDTAGGAHLAIDREGRTYLVDHTGDWYLGATLDEALTLLLTGLQPARLTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZI4</accession>
    <name>A0A0F4IZI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_28930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000889">
        <property type="protein sequence ID" value="KJY26903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26903">
        <property type="protein sequence ID" value="KJY26903"/>
        <property type="gene ID" value="VR44_28930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2126"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9297" checksum="A3DCD1D12999C256" modified="2015-06-24" version="1" fragment="single">PVPAAGGRGGDGAPDIAELLEETWRAALGMSSIDHGADFFDLGGDSLSAVGLIAEVRDRLGVELSIGMLFEFPTISALAAQLRGRTEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZJ4</accession>
    <name>A0A0F4IZJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000984">
        <property type="protein sequence ID" value="KJY26096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950926.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000984.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26096">
        <property type="protein sequence ID" value="KJY26096"/>
        <property type="gene ID" value="VR44_30885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2680"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20485" checksum="23784902BEE34757" modified="2015-06-24" version="1">MDALIGTQAPRQRLTDPASAIAALEQAVPGLALLRRTTPAGIDWATVEECLTTHLPSDYKLLADSYPSLAFGDFLCVGFPNPGQEQAWSEDPENLEILAEWCADAEMSIPLHPFPAPGGLLPWATSNQGDYFLWNTTGSGPDEWTVTVASRNGGWWHYTGGAVQFLGDLTSGALELWELPSVRPQVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZL1</accession>
    <name>A0A0F4IZL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000832">
        <property type="protein sequence ID" value="KJY27450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27450">
        <property type="protein sequence ID" value="KJY27450"/>
        <property type="gene ID" value="VR44_27495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1667"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="14312" checksum="E7468596AF01D3AE" modified="2015-06-24" version="1" fragment="single">GTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDGSDIGGGASTMGTLSGGGKQIISIGERTLIGAEAGIGIALGNECVVEAGLYVTAGTRVTLPDGQIVKALELSGADNILFRRNSVTGAVEARPYKANWGGLNEVLHSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J053</accession>
    <name>A0A0F4J053_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_27155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000811">
        <property type="protein sequence ID" value="KJY27642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27642">
        <property type="protein sequence ID" value="KJY27642"/>
        <property type="gene ID" value="VR44_27155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1620"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470593" evidence="4">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="131"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="33129" checksum="826DE8F497150024" modified="2015-06-24" version="1">MTAPRRAGAVLSALVLCLFAPALTACGADEDTTPPHAPGGLTARAGSATSVHVMWERAAPADGVTGYQVFQDGRLVRELPAEKTMVDVTGLTPQTAYAFTVRARDAAGNHSAPGPAARATTPAARAEDHLPPTAPPATTGRAEGPRTVRLSWSPATDDTGVTAYDVYQGGVRIHTAGAAESSTTLTGLQPGTAYSFTVRARDGSDNSSPDGPAVAVTTPADPAQGPGTAPGAFTAAVSPGTVDLGWTAPDTGHETSEYQLYVDDRPVTVIQFGAGAVPRGRASYRLTTTEPAGTVWTLKLRARLPDGNWGAFSEERRITLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0F2</accession>
    <name>A0A0F4J0F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000800">
        <property type="protein sequence ID" value="KJY27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950185.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000800.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3167"/>
    <dbReference type="EnsemblBacteria" id="KJY27750">
        <property type="protein sequence ID" value="KJY27750"/>
        <property type="gene ID" value="VR44_26825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1523"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="26501" checksum="031FA65B119B6C9A" modified="2015-06-24" version="1">MNAYQDQRVVVTGAGGGIGAALAHRFAAEGATVVVNDLDPARAAAVAGAIGARAIAVPGDASAVVREAREALGGRVDVYCANAGLASGGDAFAEEAVWEAAWDTNVMAHVRAARALLPDWLERGEGRFVSTVSAAGLLTMIGAAPYSVTKHGALAFAEWLSLTYRHRGVRVHAICPQGVRTDMLTAAGSAGELVLAPTAIEPDAVADALFDGMEKGRFLILPHPEVADYYAGRASDPERWLGAMNHLQQKWESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0F9</accession>
    <name>A0A0F4J0F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000943">
        <property type="protein sequence ID" value="KJY26406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950786.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000943.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000005_gene4039"/>
    <dbReference type="EnsemblBacteria" id="KJY26406">
        <property type="protein sequence ID" value="KJY26406"/>
        <property type="gene ID" value="VR44_30130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2430"/>
    <dbReference type="eggNOG" id="COG0309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="180"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="35796" checksum="3AA0E42E90B92940" modified="2015-06-24" version="1">MPETALDITGWTCPAPLRDRPRVVMGHGGGGALSAELVQHLFAPAFGGEALAQLGDSAALRLGGLRLAFSTDSYVVRPLFFPGGSIGDLAVNGTVNDLAMSGATAAYLSCGFILEEGVPMATVARVAEDMGAAARAAGVEVATGDTKVVEVGHGDGVYVNTAGIGLIPDGVDLRPQRVVPGDVVIVSGEIGLHGVAIMSVREGLEFGVDIESDCAALGGLVRAMLAVTPDLHVLRDPTRGGLAAALNEIAAASGTGVVLHEGRVPVPAAVANACAILGLDPLYVANEGKLVAFVPREHAEAVLDAMRAHPLGRHAAVIGEAVEAHPGLVVARTGLGGTRVVDLPLGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0T7</accession>
    <name>A0A0F4J0T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000845">
        <property type="protein sequence ID" value="KJY27353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27353">
        <property type="protein sequence ID" value="KJY27353"/>
        <property type="gene ID" value="VR44_27820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1802"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6380" checksum="C62B9CEC970DB473" modified="2015-06-24" version="1" fragment="single">PALPERVPQTHLTRQLRGPRAPEPDTGTDAATPEEVADAWADYEEGTKKVEAELGADQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J319</accession>
    <name>A0A0F4J319_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949983.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000747.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28259">
        <property type="protein sequence ID" value="KJY28259"/>
        <property type="gene ID" value="VR44_25765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24561" checksum="C5F751701D7384D3" modified="2015-06-24" version="1">MTHATADTGFRYEDLGRLMALMTGDEKHGPAATSTLDVLWVLYDRVLRVGLGSADEPGRDRFLLSKGHGPMAYYAVLAAKGFFPVDWLPGFGTFDSPLGHHPDRVLVPGVEIASGSLGHGLPLAVGSALGLRAQGLDEPAVWVLIGDAELDEGSNHEAIAYAGSAGLESLHTVVVDNDSATHGWRGGIASRFEAAGWSTATVDGRDHAALHAAFTAPHPGRPHAVVARVEKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J359</accession>
    <name>A0A0F4J359_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000759">
        <property type="protein sequence ID" value="KJY28138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28138">
        <property type="protein sequence ID" value="KJY28138"/>
        <property type="gene ID" value="VR44_26010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="12301" checksum="1EC923B03A49B71A" modified="2015-06-24" version="1" fragment="single">DRTPASDVHAAEAEPGGGEQEAPVRTEPDGHTTAARDSRPAQDDAPGKPGAVGADAAAEGDTPAAKASGDAPAGAPGRGTPAPEAVSAKGGAPSGGEVADEPGASAPGAEAPVRRPSWAKRDADRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Q3</accession>
    <name>A0A0F4J3Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28459">
        <property type="protein sequence ID" value="KJY28459"/>
        <property type="gene ID" value="VR44_25355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11837" checksum="2DD2F29DEB222285" modified="2015-06-24" version="1" fragment="single">MERIVEEIREDLGRRIALAADRLADRTLAEDPAYAAPLGRAAVRERMRETLHRTVEGLVSASRGEPVEVADARAAGALRAGQGLPLDPLRRTYRYGGRLVWQCLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Q3</accession>
    <name>A0A0F4J4Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_24575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000702">
        <property type="protein sequence ID" value="KJY28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949763.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3005"/>
    <dbReference type="EnsemblBacteria" id="KJY28784">
        <property type="protein sequence ID" value="KJY28784"/>
        <property type="gene ID" value="VR44_24575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.910"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="35729" checksum="16526F46EBAFE269" modified="2015-06-24" version="1">MLVYLIRRLFNVAATLLVVSVVTFGIFFAVPKLTGSDPALMYAGRETNETALAGIRVKMGFDKPISEQYLLFVKGIFAGRDYDGGTGVTHCAAPCFGYSFKTEAPVWQTMMDRIPVTLSLALGAAVIWVLAGVATGVVSALKRRTAIDRTVMVGALAGVSLPIFFTGMVAPAIFVYSLGWLDVSNYKPLTEDPLAWLNSLILPWVTLAFLFAATYARITRATMLEVLGEDYIRTARAKGLKEGVVIRKHALRSTLTPIVTMFGLDLGGLLGGAVLTETTFNFQGLGTAAVAAISQGDLPVIMGVTLLAALFVVLANLIVDLLYAVIDPRVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4R4</accession>
    <name>A0A0F4J4R4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cobalt transport protein CbiM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Energy-coupling factor transporter probable substrate-capture protein CbiM</fullName>
            <shortName evidence="11">ECF transporter S component CbiM</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbiM</name>
        <name evidence="12" type="ORF">VR44_24510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CbiM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949752.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3018"/>
    <dbReference type="EnsemblBacteria" id="KJY28799">
        <property type="protein sequence ID" value="KJY28799"/>
        <property type="gene ID" value="VR44_24510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.897"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01462">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00123">
        <property type="entry name" value="cbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 11" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24064" checksum="34B723AB1C5F5485" modified="2015-06-24" version="1">MHIAEGFLPPLHAAAWGAASAPFVVHGVRALTREVKSHPESTLLLGASGAFTFVLSALKIPSVTGSCSHPTGTGLGAILFRPPIMAVLGTITLLFQALLLAHGGLTTLGANVFSMAIAGPWAGYAVYKLLRRSGAPLMVTVFFGAFFADLVTYCVTSVQLALAFPDPASGFLGSLEKFAGIFALTQIPLAVSEGLLTVLVMRLLMQSSKSDLVRLGVAKLTGAGRTEEAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5R5</accession>
    <name>A0A0F4J5R5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_23590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000666">
        <property type="protein sequence ID" value="KJY29179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29179">
        <property type="protein sequence ID" value="KJY29179"/>
        <property type="gene ID" value="VR44_23590"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="960"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY29179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1032" mass="108708" checksum="26F7AD4B62528910" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6N7</accession>
    <name>A0A0F4J6N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000608">
        <property type="protein sequence ID" value="KJY29880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949246.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000608.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene128"/>
    <dbReference type="EnsemblBacteria" id="KJY29880">
        <property type="protein sequence ID" value="KJY29880"/>
        <property type="gene ID" value="VR44_21770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.234"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19792" checksum="B6E9AC6AA343FCB6" modified="2015-06-24" version="1">MGDLSTTDAKTVTIRRARTGDVPALRRLLDQYVQQRILLDKAPVVLYEDIQEFWVAERDSDGQVVGCGALHVMWEDLAEVRTLAVDRDLKGSGVGHQVLAKLLETARRVGVSRVFCLTFEVDFFAKHGFVEIGETPVETDVYMELLRSYDEGVAEFLGLERVKPNTLGNSRMLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6S8</accession>
    <name>A0A0F4J6S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30067">
        <property type="protein sequence ID" value="KJY30067"/>
        <property type="gene ID" value="VR44_21320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8989"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7555" checksum="05D27A34E18B6E19" modified="2015-06-24" version="1">MVDQPTPHPAQPGPEDQPVVCARCGARSPNGAPPTWTCSVENGTRQYFCVDCARANLRAIEGRLDSSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7S1</accession>
    <name>A0A0F4J7S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000686">
        <property type="protein sequence ID" value="KJY28981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28981">
        <property type="protein sequence ID" value="KJY28981"/>
        <property type="gene ID" value="VR44_24015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.795"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="7723" checksum="937EE25C875AC2BC" modified="2015-06-24" version="1" fragment="single">GAPSPAAAAAKQQPAPHEHTFANELAAPKENPQQRDSAPVAPAVAGCDRHYGSVNVCVPAAFPAEVKKTCLLYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7V5</accession>
    <name>A0A0F4J7V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29848">
        <property type="protein sequence ID" value="KJY29848"/>
        <property type="gene ID" value="VR44_21795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.239"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10570" checksum="CB51845D27261929" modified="2015-06-24" version="1">MIRHRFRRDGAAMGALDSAGSGTGPLVEALSRHIENDPDFAEDLRDWIKEYGSGPGSGAGQSTQLRHSNQVIGTVHGSVIQGQNVRGRFSLRGLRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J914</accession>
    <name>A0A0F4J914_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29426">
        <property type="protein sequence ID" value="KJY29426"/>
        <property type="gene ID" value="VR44_22980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.533"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="931" mass="101164" checksum="960C62443D13C8D8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9E0</accession>
    <name>A0A0F4J9E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949390.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29581">
        <property type="protein sequence ID" value="KJY29581"/>
        <property type="gene ID" value="VR44_22540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.398"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18845" checksum="A23172C092493ACA" modified="2015-06-24" version="1">MSPVSHATSEPRGEGRWLLRFEVHVPYAYESLWPFLTTGDGLRTWLAAADVLERRLGGAVTLRWLNSGTTVSGEVTAWDTERVVEYTVSEHGRIRFHLEPVGTDSTVIRFLNERAGSDAERLDCLAGWHDHFEMLEAALAGHPADWPSWTDTRWSELRASYASFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB80</accession>
    <name>A0A0F4JB80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000479">
        <property type="protein sequence ID" value="KJY31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948490.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000479.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31622">
        <property type="protein sequence ID" value="KJY31622"/>
        <property type="gene ID" value="VR44_17740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8045"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9085" checksum="599EE343AB7A7C34" modified="2015-06-24" version="1">MIERAYQQGAIAALPKTHDRTIPTFPQAETETLSILSVRFQWGSLLTAAGAVATVMGSATAGVLLALAPAVLTDGTVVTYLRIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBB2</accession>
    <name>A0A0F4JBB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000518.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31089">
        <property type="protein sequence ID" value="KJY31089"/>
        <property type="gene ID" value="VR44_18915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8323"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="24"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="444" mass="45625" checksum="A28DF306BF75B7E4" modified="2015-06-24" version="1">MTSAAPVPTLAHHTLLVLLLQLSLLLLLALTLGRLAARFRMPAIVGELLAGVLVGPSVLGHLLPGLAGRLLPQQPEQMHLLDAVGQLGVLLLVGVTGMELKFGLVKRRGTTAVRVSLAGLLLPLGLGIGAGYLLPASLLPGDTDPTLFALFLGVALCVSAIPVIAKTLMDMNLLHREIGQLTLAAGVIDDVIGWFLLSVVSAMATAGLTAGRLTASLLYPVGVVAFALLVGRPAVRLALRAAGRSPEPGPTVAVAALTVLLGSAGTHALGLEAVFGAFVCGALISTSGELDPEKLAPLRTTVLAFLAPVYFATAGLRMDLTALARPEVLAAACAVLAVAVLGKFAGAYTGAKLSRLNNWEALALGAGMNSRGVIEVIVAMTGLRLGILGPETYTVVVLVAIVTSLMAPPILRTAMARVEERAQTELALADDDPHGLSPRRATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC11</accession>
    <name>A0A0F4JC11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000503">
        <property type="protein sequence ID" value="KJY31283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31283">
        <property type="protein sequence ID" value="KJY31283"/>
        <property type="gene ID" value="VR44_18460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8287"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15944" checksum="C9ADF0BE1EA5F160" modified="2015-06-24" version="1" fragment="single">PDPVGHAVEARLYAEDPALDWRPQTGVLHTLSLPEHVRVDTGFTDGDTVSVHYDAMLAKVVAHAPTRAEAVRVLADALARARIHGPATNRELLVRSLRHPDFTAARIDTGFYDRHLDTLTAGAPDPALACLAAALAEAAPAPGAPLAARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCA2</accession>
    <name>A0A0F4JCA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000450">
        <property type="protein sequence ID" value="KJY31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948363.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000450.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31967">
        <property type="protein sequence ID" value="KJY31967"/>
        <property type="gene ID" value="VR44_17045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7939"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="10031" checksum="42783F743F7ECCAE" modified="2015-06-24" version="1">MAIEVRIPTILRTYTDGEKAVTGEGATLSELFADLETRHKGIEERIVEGGQLRRFVNVYLNDEDVRFIEGIATPLKDGDSVTILPAVAGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCG1</accession>
    <name>A0A0F4JCG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31484">
        <property type="protein sequence ID" value="KJY31484"/>
        <property type="gene ID" value="VR44_18075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8162"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16354" checksum="4A1A280F3AC0F7D7" modified="2015-06-24" version="1">MPHDPAYAPPYGHAPAPGCRNCGAPQAALFSVRAHVGVLVLMRFHTLNGPFCRPCGRSLVRTMTTKTLCQGWWSPLSLVLFTPFTLFWNLLAAIKFGKLPDPTPAPGRQPLEEGPPVHARPLAYVAIIPLLWFTWVIVNIYLDATGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCP9</accession>
    <name>A0A0F4JCP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000436">
        <property type="protein sequence ID" value="KJY32132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32132">
        <property type="protein sequence ID" value="KJY32132"/>
        <property type="gene ID" value="VR44_16515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7703"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17229" checksum="D9BC4AE0F9A76169" modified="2015-06-24" version="1" fragment="single">MADAPYDAASARAGAVPWVARGAFVTELLTLRAEGRSGEAHALLCEAALWPAGELPGLAEELGHAGLAADWTTLLWEAASLPPDRLAAAAGALGEAGREEDADRLLPQGVARPAAEVAEAALALGAAGRDRETRALLEAFVRLRTADETAALARHDPHWFTPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDS2</accession>
    <name>A0A0F4JDS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948137.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32482">
        <property type="protein sequence ID" value="KJY32482"/>
        <property type="gene ID" value="VR44_15850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7578"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="43368" checksum="18E3BF497D0C4DB1" modified="2015-06-24" version="1">MSVEQVPVSFFDDPHPAYRRWRELEGGAHRVRILGEAPLEGWVVTGHAACKAALADPRLSKNAATEAFDRRDGSEEGPGPGRALTAHMLNSDPPAHTRLRRLVQQAFTARRVAALRPVVEGHVNRLLDGLARTPEPDLVRDFAVPLPLAVVFDLLGASEGAGHILEAWAATLNGEEGDGEVSVPTAEALVGHIRALLAHKRAHPGDDLLTALIHAHDDGDRLSEREITSMSFLLVAAGHQTTANLISNGVHALLTHPRELAALRADPSRTGAFIEEVLRHESPFSIATMRYATEPVTIDGTTIPAGDFVQIAMLSANRDPAVFPDPDRFDPSRPATGHLAFGHGIHHCLGAPLARLQAETAFTTLLTRHPTLRLATPTARPQWWRNPRHRGLRTLPVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE00</accession>
    <name>A0A0F4JE00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000405">
        <property type="protein sequence ID" value="KJY32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948117.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32577">
        <property type="protein sequence ID" value="KJY32577"/>
        <property type="gene ID" value="VR44_15725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7548"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27664" checksum="288293B0F1BBBBA3" modified="2015-06-24" version="1">MLGTDFRTGSPNWLDLGSPDTGAAAAFYREVFGWDFVSAGPEAGGYGFFQQGGRTVAALGPLTEEDGDSAWTVYFQSPDIRATADAVMRAGGQVRVAPMDVMGEGWLAQFTDPQGARFACWQPGKTAGLEVASAENSLVWVELHVPDPEAALRFYGGVFGWRSAEMEAPGMTYRVLSLAEGDQQQTSFGGVAPQGEGAGGASTIPSRWVPYFHVADADAVVAKVEGAGGAVLMPAANVPDVGRIAWAADPAGAVFAVLRPDPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEI7</accession>
    <name>A0A0F4JEI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000435">
        <property type="protein sequence ID" value="KJY32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3669"/>
    <dbReference type="EnsemblBacteria" id="KJY32168">
        <property type="protein sequence ID" value="KJY32168"/>
        <property type="gene ID" value="VR44_16510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7701"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="45732" checksum="FA92372590817D7B" modified="2015-06-24" version="1">MTDPTPLHSRHRTVLPDWLALYYDRPIELTHGEGRHVWDAEGNRYLDFFGGILTTMTAHALPEVTKAVSEQAGRIIHSSTLYLNRPMIELAERIAALSGIPDARVFFTTSGTEANDTALLLATAYRRSNQILAMRNSYHGRSFSTVGITGNRGWSPTSLSPLQTYYVHGAVRTRGPFAHLDDAAFTAAAVADLEDVLGQARGGVAALIAEPVQGVGGFTSPPDGLYGAFREVLNRHGILWISDEVQTGWGRTGDNFWGWQAHAQNGPPDMLTFAKGIGNGMSIGGVVARAEVMNCLDSNSISTFGGSPVTMAAGLANLAYLLDHDLQGNARRVGGLLLERLRALAAASPAVRDVRGRGLMAGLELTEPGTDRADPQAAAAVLEAARAGGLLIGKGGGHDTSVLRIAPPLSLTVAEAEEGAEILGQALRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JES0</accession>
    <name>A0A0F4JES0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000423">
        <property type="protein sequence ID" value="KJY32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32263">
        <property type="protein sequence ID" value="KJY32263"/>
        <property type="gene ID" value="VR44_16275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7708"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="11164" checksum="6A7AD62960F62415" modified="2015-06-24" version="1" fragment="single">GWVQARLRRWDRAIPLLYEAATAPGPSYRHLFTAELLAAFAGAGAWREAEELIGRIAPRAAAIGSVRTTETLAATAAGLRHRRGAPASLRDAAAHLRVRESLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEY8</accession>
    <name>A0A0F4JEY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">VR44_18005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948541.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5643"/>
    <dbReference type="EnsemblBacteria" id="KJY31521">
        <property type="protein sequence ID" value="KJY31521"/>
        <property type="gene ID" value="VR44_18005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8146"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="486"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="633" mass="69731" checksum="E45AD7E0E3DBB381" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF27</accession>
    <name>A0A0F4JF27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase ECF-subfamily sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_16120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000416">
        <property type="protein sequence ID" value="KJY32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948189.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000416.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32378">
        <property type="protein sequence ID" value="KJY32378"/>
        <property type="gene ID" value="VR44_16120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7647"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="SSF110221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AbfB" evidence="6">
        <location>
            <begin position="394"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="525" mass="55352" checksum="7C509AC1CAFABD84" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG49</accession>
    <name>A0A0F4JG49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3068"/>
    <dbReference type="EnsemblBacteria" id="KJY31926">
        <property type="protein sequence ID" value="KJY31926"/>
        <property type="gene ID" value="VR44_17100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7952"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22858" checksum="00AEC126D1C24FCF" modified="2015-06-24" version="1">MRNPCSRSTPQPGRTGRPRSAAADAAILAATRDALVELGWSKLTMGDVSARAGVAKTTLYRRWAGKNELVVDAVAELFDALELPDRGSLEADIEYVVLQFAALLRRPEARTALMAVVAESTRDEALRDRIRSAIVDRQKRLVVLGRERAQARGELPYEEDQSLAGHTTDLIFDVIAGTVVHRALVSSEPVDEGWVAAFTALLMHGLTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGP8</accession>
    <name>A0A0F4JGP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947809.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33400">
        <property type="protein sequence ID" value="KJY33400"/>
        <property type="gene ID" value="VR44_14020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7107"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7665" checksum="ADF40057C3A651FF" modified="2015-06-24" version="1">MVLTPQERMRAAEEAVRQLRESLEGVGVTFPSLDVDGVSAASTYGLPLVDLGRCNLDTALRLAAVLHERAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGU0</accession>
    <name>A0A0F4JGU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_14845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000380">
        <property type="protein sequence ID" value="KJY32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947950.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000380.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32963">
        <property type="protein sequence ID" value="KJY32963"/>
        <property type="gene ID" value="VR44_14845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7366"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24001" checksum="1E87BDCDF1B693B8" modified="2015-06-24" version="1">MRINRILLAGSLVSVALVLQVTVLGRLQLPGAVPDLVLLTVVALALVYGHVSGALIGFAAGLLTDLAPPADHAAGRYALVLCLIGYLVGLARPDSGRFRSAWGPMLTVVAAAIGSTLLYAGVGALVGDTAARHVGLVGLLFTATLYDLLLAPFTVPFIMALARRAENDPMAVEANGGPPQGKDVASGWLAGGTGLRIGSQRGGLRLMTARGRANRAGRIKGVKGVKGVKSVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGW6</accession>
    <name>A0A0F4JGW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32988">
        <property type="protein sequence ID" value="KJY32988"/>
        <property type="gene ID" value="VR44_14815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7360"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="111"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35478" checksum="532E4D7EEFE68A7A" modified="2015-06-24" version="1" fragment="single">MSEQQPEGQDRDRDGTFDEFDQIVAEEADRDPDLAVIEAGSRTLRAQAGPPSGDPVPARPEDPEVAKALLEVEQELATRWGETKLDPSVSRIEALMDVLGQPQRAYPTIHVTGTNGKTSTARMIEALLNAFELRTGRYTSPHVQSVTERISLDGAPISAERFIETYHDIKPYVEMVDAAEDFRLSFFEVLTGMAYAAFADAPVDAAVIEVGMGGTWDATNVIDASVAVITPISLDHTDRLGSTPGEIAGEKGGIIKQDATVILAQQPVDAAQVLLKRAVEVDATVAREGMEFGVVSREVAVGGQMLTLRGMGGEYDNIFLPLYGAHMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH00</accession>
    <name>A0A0F4JH00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947917.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33028">
        <property type="protein sequence ID" value="KJY33028"/>
        <property type="gene ID" value="VR44_14645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7256"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15653" checksum="7E5976FD639ACAB3" modified="2015-06-24" version="1">MTSMPPEERIGSHIKRAEQALLAAKTTACKPAAVTVPQYAALLWLAEKPGISAAALARLCGVTAPTMNTVLKNLHERGLVERTPHEWHRNVLETRLTPEGRAAMELADAGAVRVERALAAAFSPEEREQLVALLGRCAEVLDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHI4</accession>
    <name>A0A0F4JHI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947653.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene723"/>
    <dbReference type="EnsemblBacteria" id="KJY33812">
        <property type="protein sequence ID" value="KJY33812"/>
        <property type="gene ID" value="VR44_13170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6852"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="453" mass="50058" checksum="9F63BB1BF421E6D5" modified="2015-06-24" version="1">MSQDLSKTAYDHLWMHFTRMSSYENAPVPTIVRGEGTYIFDDKGKRYLDGLAGLFVVNAGHGRKELAEVAYKQAQELAFFPVWSYAHPKAVELAERLADYAPGDLNKVFFTTGGGEAVETAWKLAKQYYKLQGKHTKYKVISRAVAYHGTPQGALSITGLPALKAPFEPLVPGAHKVPNTNIYRAPIHGDDPEAFGRWAADQIEQQILFEGPDTVAAVFLEPVQNAGGCFPPPPGYFQRVREICDTYDVLLVSDETICAFGRLGTMFACDKFGYVPDMITCAKGMTSGYSPIGACIVSDRIAEPFYKGENTFLHGYTFGGHPVSSAVALANLDIFDKEGLNQHVLDQEGNFFSTLQKLHDLPIVGDVRGNGFFYGIELVKDKVTKESFTDEETERVLYGFLSKALFDNGLYCRADDRGDPVIQLAPPLIADQGTFDEIEGILRNVLTEAWTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHV0</accession>
    <name>A0A0F4JHV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947803.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7195"/>
    <dbReference type="EnsemblBacteria" id="KJY33394">
        <property type="protein sequence ID" value="KJY33394"/>
        <property type="gene ID" value="VR44_13990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7099"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="27864" checksum="AB714C646227381D" modified="2015-06-24" version="1">MSNGGQRTFGPLGTTLVIIPTYNEAENIGRIVGRVRAAVPEAHVLVADDNSPDGTGKLADELAAEDDHVHVMHRKGKEGLGAAYLAGFAWGLEHGYGVLVEMDADGSHQPEELPRLLTALAGADLVLGSRWVPGGRVVNWPKSREFLSRGGSTYSRLMLDVPIRDVTGGYRAFRRETLEGLGLDEVASAGYCFQVDLARRAVRKGFRVVEVPITFVERELGDSKMSKDIVVEALWRVTQWGLGERLAKLTGGTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHW6</accession>
    <name>A0A0F4JHW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_14115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947826.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33363">
        <property type="protein sequence ID" value="KJY33363"/>
        <property type="gene ID" value="VR44_14115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7137"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="321"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="853"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="962"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1055" mass="112661" checksum="6AC5A99284323672" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIH7</accession>
    <name>A0A0F4JIH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_12505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000311">
        <property type="protein sequence ID" value="KJY34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34152">
        <property type="protein sequence ID" value="KJY34152"/>
        <property type="gene ID" value="VR44_12505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6561"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="89"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="368"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="666" mass="71446" checksum="04201404D9EB3B71" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK99</accession>
    <name>A0A0F4JK99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947805.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33396">
        <property type="protein sequence ID" value="KJY33396"/>
        <property type="gene ID" value="VR44_14000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7102"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471125" description="Inhibitor I9 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="10201" checksum="ED6CA57B62E0F65A" modified="2015-06-24" version="1">MRTRVSRVLPLAAAVLAAVAAVLPLSTAAVGEPAPPSYIVTVRPGVDPAGVAAQVGGVHPDRYFHHTLNGFAARLTPRQVADVAALPGVLAVETDGTAGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKI5</accession>
    <name>A0A0F4JKI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000266">
        <property type="protein sequence ID" value="KJY34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34705">
        <property type="protein sequence ID" value="KJY34705"/>
        <property type="gene ID" value="VR44_11475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12659" checksum="E721A2A45201AC2C" modified="2015-06-24" version="1" fragment="single">PEQCVAVAARVMERRHVDRLPVVDEEDRLVGIATRRDLLRVFRRTDDEIRSDVAAEVSAHLPASGGAAVRVQVKDGVVTLQGLASPSVDPFALLRAAWRVEGVVGVMHSRRPDDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKP7</accession>
    <name>A0A0F4JKP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000291">
        <property type="protein sequence ID" value="KJY34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34399">
        <property type="protein sequence ID" value="KJY34399"/>
        <property type="gene ID" value="VR44_11930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6467"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="2">
        <location>
            <begin position="110"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="38754" checksum="2F874EC95A493C95" modified="2015-06-24" version="1" fragment="single">AWAGIRARGGGVGRERWLPVAKAVVVGVALLLVFGGLFASADAAFADLLGGLVPDVSVGEGPLRTLLFLGGSLLALATARTAAAPHRWDRIKSRPGKARSRLEWSLPLILLDLLFAGFNAVQLAVLFGGYDKVLESTGLSHAEYARQGFWQLLWATVFVLAVIALALRWAPRGTPGDRRLVRAVLGTLCLLTLVVVASAVRRMELYVDAYGLTRLRLSVVTMELWLGLVIVLLMAAGAVGRRRLARAVAGSAAAAVLAFGLLSPDALIAENSVTRYQQEGKIDLAYLRGLSADAAPALDRLPEPRRSCALMGIRDDLRQAGDLPWYATSLGQYRAREILRARPVTASRSECAGLGAYGSRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM07</accession>
    <name>A0A0F4JM07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35387">
        <property type="protein sequence ID" value="KJY35387"/>
        <property type="gene ID" value="VR44_10210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5908"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="32855" checksum="390F6EF3BB867E7F" modified="2015-06-24" version="1">MVEREHGHIGSAQAVLGLLVVGGMALGALLLHPGAGLFAEGRGPLGENPVLVLGLALLSLFGGIALRAKYVERIGAQETLDPVEQRLADGVRRVLTAAPPALPLLIVALHRFGAPDSDSGGGAPPNGGGPGPSSLPLAPPVPVPTAPPAPPAAPDAGSHSGLTRVLLVLGLALLTAALVLAFRLLWRYLRHPTEPEAAAVAETPGGEREPLAAAVDRGRRALQDATDVSAAVIACYLAMEESLADSGVARHASDSPHDLLERALHGGLSAADAATELTALFREARYSTHPMHGGHRDRAAAALAEIAHGLRPQGDGPRAGAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMI7</accession>
    <name>A0A0F4JMI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34963">
        <property type="protein sequence ID" value="KJY34963"/>
        <property type="gene ID" value="VR44_11125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6109"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="53" mass="5831" checksum="94CE052E16417513" modified="2015-06-24" version="1" fragment="single">RPGADPAEVTDAAERLTALLEGLSVRRLSGLLPLEHARRLMREAVRVEVDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNN4</accession>
    <name>A0A0F4JNN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947106.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35378">
        <property type="protein sequence ID" value="KJY35378"/>
        <property type="gene ID" value="VR44_10250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5918"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25491" checksum="E82DB4F005870CD5" modified="2015-06-24" version="1">MSGIQGKVIAITGASSGIGEATAAYLAAKGAQLVLGARREERLNSVVDGITAKGGTAAGVVVDVTRREDLQRLTETALNRYGRLDVLVSNAGTMAVSPFDDLRQDDWDTMVATHITGLLNGIGAALPIFRRQRFGQFVNVGSTAAYVVKSPQGVYAATKTAVKVLTEGLRQESGPDLRVTLVSPGFTHTEGIGKGASPEAAAAMTRQRDEIAMPPSAIASAIGYAIEQPDGVDVSEIVVRPTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP00</accession>
    <name>A0A0F4JP00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AdoMet activation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000220">
        <property type="protein sequence ID" value="KJY35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35473">
        <property type="protein sequence ID" value="KJY35473"/>
        <property type="gene ID" value="VR44_10180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="4">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="19360" checksum="8FF56F4EBB78814F" modified="2015-06-24" version="1" fragment="single">ATLPELKQRRVAKRDTPALQVEEPEQPGGRSDVAVDNPVPTPPFWGTRVVKGIPLKDYATWLDEGALFKGQWGLKQARAGGATYEELVENEGRPRLRGLLEKLHTENLLEAAVVYGYFPCVSKGDDLIILDEQGNERTRFTFPRQRRGRRLCLADFFRPEESGETDVIGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPG1</accession>
    <name>A0A0F4JPG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946823.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36065">
        <property type="protein sequence ID" value="KJY36065"/>
        <property type="gene ID" value="VR44_08725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4988"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="31001" checksum="0B589FC5A991408F" modified="2015-06-24" version="1">MERTLVVGVDGSPESRAAADWAAREAVRRDMRLHVVHAWSWQPLALPVVQDHDTEAGRAQEVLEETRAELTRRHPRLSLTAEVVPDAPVPALLRAAKDAEMLVLGSRGHGALAGFLLGSYGQQLIAAAECPVVSVRARHGIAVPGSDEGEVVVGQQGGVADSADVLRFAFETAASRKAPLRAVRAWNLPPVYGYSPGSMWIADRFGGLEPFEKAALEQALEPWRTRYPEVDVVAHVELGGAGHVLLSAASDAGLLVVGRQVRESGLGTRIGSTAHAVLHHSACPVAVVPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRC3</accession>
    <name>A0A0F4JRC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000142">
        <property type="protein sequence ID" value="KJY36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946553.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000142.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36740">
        <property type="protein sequence ID" value="KJY36740"/>
        <property type="gene ID" value="VR44_07300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3931"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="24409" checksum="074CC5EF7C0AB750" modified="2015-06-24" version="1">MADTADQKKSDHRSGKKRRFLPPPAWWPLPACALLGLAAGGVYGVLKAPEYAATSYVVAVPNETTEPATAQGFAQAYGRIATSSSTLAYAQPRAGVGAQQLRTQVRAETSPDSPMIAITGTSKSASEAADIANAVADALSLSSNQAAKNTGVQLLLFSQAVAPTEPASPSASISAAVGLCAGGLLGGLWLLARPARRRPAEQDETERPAVEEYASLPAQGEHSEHSETKEKESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS2</accession>
    <name>A0A0F4JRS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946508.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36895">
        <property type="protein sequence ID" value="KJY36895"/>
        <property type="gene ID" value="VR44_07020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3619"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16395" checksum="BC0A2F3783809721" modified="2015-06-24" version="1">MADEQQHAVKFPQEVLDEYASLGIDLPALFSAGALGERMEIRILEASADRVVATMPVKGNTQPYGLLHGGASAVLAETLGSVGAMLHGGSRKIAVGVDLNCTHHRGARDGIVTGTATPVHRGRSTATYEIVITDEQDRRVCTARLTCLLRETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS04</accession>
    <name>A0A0F4JS04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946392.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37147">
        <property type="protein sequence ID" value="KJY37147"/>
        <property type="gene ID" value="VR44_06395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3188"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11769" checksum="6537745290ED6D4A" modified="2015-06-24" version="1">MSTVPPRIPDPRTGQAERRAHIAAVIAELTAEHPDATLVYDAVMDVLAAVDRIPGAVLEIRLPGVLDVHDMTALGDTLTEGRTWRTGRLTEATGVTEHGAHVRVMTEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS93</accession>
    <name>A0A0F4JS93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000124">
        <property type="protein sequence ID" value="KJY37035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37035">
        <property type="protein sequence ID" value="KJY37035"/>
        <property type="gene ID" value="VR44_06700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11844" checksum="375141671898961A" modified="2015-06-24" version="1">MCGEGDALKVVRVQRHGVLRLPAGGRAGGRDALAVLRPDAQLAEIQVEMGIREMDRTFERGFGHPVWPSRAPAPEQAAGRRAGHRRPAHGGIRPPPARPPGRRGGPGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSF3</accession>
    <name>A0A0F4JSF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946869.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35881">
        <property type="protein sequence ID" value="KJY35881"/>
        <property type="gene ID" value="VR44_08950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4961"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_7C" evidence="2">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="30925" checksum="9978CE3B2BBC2B7C" modified="2015-06-24" version="1">MNRPDHTPTAAPHVAVITLVAGRHRHLALQQTALSRSDRRPDTYVVVTMDDAIAAAIAARGSPAATVVPMAVPRSGRFPLAAARNAGARRALALGADVLVFLDVDCVPGPQSVGRYTEAAVNGVLLCGTVTYLPPPPVGGYRLAGLPELADPHPGRPVPRPDQLLTGGDPDLFWSLSFTLTASTWRRIGGFCEEYTGYGGEDTDFACLAHRAGVDLCWLGGAPAYHQHHPVEDPPVRHLHDILRNGALFHRRWGRWPMEGWLHAFADLGLVRFDTAAGAWTATPSTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT98</accession>
    <name>A0A0F4JT98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000171">
        <property type="protein sequence ID" value="KJY36196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36196">
        <property type="protein sequence ID" value="KJY36196"/>
        <property type="gene ID" value="VR44_08390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4577"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="21637" checksum="021A5400B1BE12D3" modified="2015-06-24" version="1" fragment="single">MSTPPTPPHDPSGPPIPEGAAPGHPAAPDPAAAPAEGPTGTPPAAPAPEQPPAEPAPQTPAEDLAETARLSFDKPATPAQPQDTPDPAADLAETARLPQPVPQDAPVPAADQAETARLSLDKPPAEPAPETPAEPLAETARLSFDKAATPQDPAAPAAGGETARGSWEKPEAAAPAAPPVQPAPAAGGGAPEGYNPWAAPAPGAFAAPGGGAHAGFAQPAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTG8</accession>
    <name>A0A0F4JTG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_06675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000123">
        <property type="protein sequence ID" value="KJY37043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946448.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000123.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37043">
        <property type="protein sequence ID" value="KJY37043"/>
        <property type="gene ID" value="VR44_06675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3253"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="43"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="45819" checksum="6AD8292EC3F64F12" modified="2015-06-24" version="1">MKRLEFCMSERGPSAAPSHEPSASPSAAAAVPLTAARRTGLLVTFILGGLTALPPLSMDMYLPALPEVTAALSSPAATIQLTLTSCLAGMALGQLVIGPMSDKWGRRRPLLTGMAVYVLATAICALAPSAGLLIGFRLLQGLAGAAAIVIARAVVRDLYDGVEMARFFSTLMLISGTAPIVAPLIGGQVLRFADWRGVFVVLTAVGLALTLVVWRGLGETLPPERRQTGGVGAALRTMRGLLSDRVFAGYTLAGGFAFAVLFSYISASPFVVQEIYGASPQAFSLLFGLNSVGLIVVGQVNGKLLVGRVSLDKVLAVGIAVLTAASVALLLMSTGVFGTVGLLPVAAALFVLMSTMGLVLPNTNAQALMRTPHAAGSASALLGTSSFLVGAVASPLVGIAGERTAVPMALVQLSCSLLAAGCFLALCRPWREREPMAAAADPAAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX0</accession>
    <name>A0A0F4JTX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946335.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37279">
        <property type="protein sequence ID" value="KJY37279"/>
        <property type="gene ID" value="VR44_06105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2557"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="32716" checksum="279D6E6B18CBEE72" modified="2015-06-24" version="1">MPPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAGTVYPRLAKLEAEGLVTYATEGGRKVYSITDAGRAELADRRGELADLELEIRDSVSELAAEIRDDVRGAAGDLRREMLAAANASATQPEDESWKAAKEELRKARQEWKEQARRAKDESRRAREEAQQARRQAKEAAKEAQERAREEVQRIAAQLQEQLSRTGGVFGSLAGAWLGGNSTAAAPGTPTAPGPSGSGWAEDLAPSADPARDLDRLLDRFRDDIRDAARDHGVTPAQLSEARAHLAAAAARIEAGLRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU48</accession>
    <name>A0A0F4JU48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946338.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5800"/>
    <dbReference type="EnsemblBacteria" id="KJY37283">
        <property type="protein sequence ID" value="KJY37283"/>
        <property type="gene ID" value="VR44_06125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2561"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="172"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41155" checksum="AE213D036A2A48CE" modified="2015-06-24" version="1">MAAEIVNPRSDSATDNNPDAVFALHRGGKMAIQATVPVKDKDDLSLAYTPGVAKVCTAIAEQPELVNEYTWKSNVVAVVTDGTAVLGLGDIGPEASLPVMEGKAILFKQFGGVDAVPIALATKDTDEIVETVIRLAPSFGGVNLEDISAPRCFEIERRLQEALDIPIFHDDQHGTAIVTLAALRNAAKLTGRTLGDLRAVIAGAGAAGIAIAKILVDAGIGDVCVTDRKGVVSADRTDLTDVKAEIAGLTNKTGLNGTLEEALAGADVFIGVSGGTVGEEAVASMAKNSFVFAMANPNPEVHPDIAHKYAAVVATGRSDFPNQINNVLAFPGIFAGALKVRATRITEGMKIAAADAIAGVVGDELAADYVIPSPFDERVAEAVTAAVAAAAKADGVARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUD4</accession>
    <name>A0A0F4JUD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946050.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37952">
        <property type="protein sequence ID" value="KJY37952"/>
        <property type="gene ID" value="VR44_04580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.996"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13259" checksum="C0141F520DE875C5" modified="2015-06-24" version="1">MGWRHTDAETPVRRGADGQFYVAAQDVTAILRDMARTFDLHARSDGGAWTAGDRTTPVRLDEDTMRTVASILRAQADEMDDQLIAIAATSTARTAGSPSAWRQEAAKPAAKGRGRRKNCDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUF0</accession>
    <name>A0A0F4JUF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946107.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000090.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37810">
        <property type="protein sequence ID" value="KJY37810"/>
        <property type="gene ID" value="VR44_04865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1057"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="25581" checksum="43B98655E1D4019C" modified="2015-06-24" version="1">MGTLDGKTALVTGASRGIGRAVALRLAAEGALVAVHHGGNEEAAAGTVARIEEAGGRAFAVRARFGEAGAVDALFEGLTAGLAGRGLDVLVNNAGIGSGSSIAQVTEEEFARLLAVNVTTPFFVIQRALPLLNDGGRIVNMGSTASRFAVTSQIGYTVTKAALEAMAPSLANELGRRGITVNTVAPGAVRTDMTAGYTAVPEVVAALEGITALGRLGEPEDVADVVGFLAGPQGRWMTGQTVDVSGGTWLGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUU6</accession>
    <name>A0A0F4JUU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_05425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7141"/>
    <dbReference type="EnsemblBacteria" id="KJY37604">
        <property type="protein sequence ID" value="KJY37604"/>
        <property type="gene ID" value="VR44_05425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1721"/>
    <dbReference type="eggNOG" id="COG3548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY37604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="24146" checksum="0288D54412B93D12" modified="2015-06-24" version="1">METETNRVEAFSDGVFAIVITILVLELKVPEEQGSALWHGLLEQWPHYAAYLVSFLIIGVMWVNHHTIFSHLKRVDRPLLFLNLMVLMVVSVIPYTTNILAEHLMDGDSANVAAILYSSWTVVYALAFLGFWWYVTKVGHLFHETVDKDGARATRVRFGLGAVAYPLTVILSFFSAPLTLVAHFLIALYYAANQIPIPLVVEEERLETGSDLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUW8</accession>
    <name>A0A0F4JUW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000137">
        <property type="protein sequence ID" value="KJY36781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36781">
        <property type="protein sequence ID" value="KJY36781"/>
        <property type="gene ID" value="VR44_07235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3788"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="143"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="40665" checksum="30726547FA9FF3D5" modified="2015-06-24" version="1">MGLGRQSEGRSGDGAAWQVVRVLPFLLILLGLVFDLLTPPRFTGAPFFTAAPLIAAPLFSLGATALTGIASSAAVVGLHLYNGTSWRAEALTELVTVLTVSGLALLINRVVRRSGERLASARGIAEAAQRAVLPTPAERIGGLHVAARYEAAQADAFIGGDLYAVQDTPYGVRLAVGDVRGKGLGAVEAVAVVLGAFREAAETEPTLEGLARRLERALAREGTRREGLDAEEGFTTCVLGEVPPGAELLRLVNRGHPEPLLLYADGGLAVLAPAEPALPLGLGELAAGPPGTAGEWPFPPGSTLLLFTDGLTEARDRSGVFYDPAVRLRGRVFSGPDEVLSALSSDVRRHTGGGTTDDMALLAVGRAGEGQPERRRTVPVVRREEGSGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVC3</accession>
    <name>A0A0F4JVC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946123.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37799">
        <property type="protein sequence ID" value="KJY37799"/>
        <property type="gene ID" value="VR44_04950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1077"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="235"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="44361" checksum="4475819D3D9757EA" modified="2015-06-24" version="1">MGRVRSWVVRAGAGFWRAAVVVAVCMPVPAVWAGAVGLAVWCGAEHPWSWIGPAVIVCAGTLALAQSVCRAVRVLVARWTGTAIPGGYREAGPVMQLSTGYWWNGFSYERSRRDAVMDQRMRLWWSDPATWRDLRFAVIAPFTAGLAAALPPAALAVAALGLTGVGPAGSGTVGRLVGAAATAVAVGCSPYAWRALHRVAVRFLGPSAAMVLAERVDELTSQRADATVAQAAEIRRIERDLHDGAQARLVALGLSLATAEALMDRDPEQARTLMREARAGAAASLTELRELIRGISPPVLSERGLVDAVRALALDVPLDVAVRAAGPLRLDPPIESAVYFGVAELLTNAVKHAGANRAHVSLVRDETGIVVEVEDDGRGGADARPGGGLAGLRRRLAVFDGTLTVTSPHGGPTRVRMAVPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVD4</accession>
    <name>A0A0F4JVD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="11" type="ORF">VR44_03835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000070">
        <property type="protein sequence ID" value="KJY38327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945922.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000070.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene774"/>
    <dbReference type="EnsemblBacteria" id="KJY38327">
        <property type="protein sequence ID" value="KJY38327"/>
        <property type="gene ID" value="VR44_03835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8670"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28090" checksum="DF37A68C826B4A32" modified="2015-06-24" version="1">MSELSNAEKQADSNNAASSHTLLEGRLGYQLESALLVRALTHRSYAYENGGLPTNERLEFLGDSVLGLVVTDTLYTTHPDLPEGQLAKLRAAVVNSRALAEVGRGLDLGSFIRLGRGEEGTGGRDKASILADTLEAVIGAVYLDKGLDAASELVHRLFDPLIEKSSNLGAGLDWKTSLQELTAAEGLGVPEYLVTETGPDHEKTFTAAARVGGVSYGTGTGRSKKEAEQQAAESAWRGIRAAADERKAAEAASAAADGASAPADPATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVU4</accession>
    <name>A0A0F4JVU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37091">
        <property type="protein sequence ID" value="KJY37091"/>
        <property type="gene ID" value="VR44_06500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3213"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15568" checksum="0988B378500DDB05" modified="2015-06-24" version="1">MRRTFDPPPSNAAYRALPGVATYPTPPPGCYWASEVCWWAIRPGPVVLRVRRIGHEHNSHHFIRAAIVDLCLGEDEPILEEVGLPSVSLSRDVEHMTEWTAVEISRNGRRRPWRAAEIEDGPFAALAGCLEWEAADADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX66</accession>
    <name>A0A0F4JX66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38745">
        <property type="protein sequence ID" value="KJY38745"/>
        <property type="gene ID" value="VR44_02925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7317"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PTHR21325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="4">
        <location>
            <begin position="42"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="29849" checksum="202E4C0093B71689" modified="2015-06-24" version="1">MAVAVLAATVTGCDDGGPPSKGGGGGAQARPRWNPAPVSVAAVGDSITRGFDACSVLADCPEVSWATGSDPAVNSLAARLLGGAEAPARSWNYAVTGSRMADLPGQLAEAAQHKPGLVTVMVGSNDACRPTASSMTSVADFRAEFEQALKVLRAASPDSQVYVSSVPDLQRLWNQGKDSPMVRQIWKLGICQSMLAEPLSIDAGATARREKVRARVVEYNEVLRQVCAKDELCRYDGGAVFQYPFGAEQLSRWDWFHPGRDGQARLAELAHRQVTAAEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXL9</accession>
    <name>A0A0F4JXL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945833.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6603"/>
    <dbReference type="EnsemblBacteria" id="KJY38574">
        <property type="protein sequence ID" value="KJY38574"/>
        <property type="gene ID" value="VR44_03315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7880"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25860" checksum="D8D4D4631F820E03" modified="2015-06-24" version="1">MTRGTQDETTAEAGHRADGLELTTAGLPGWLDPVVEAARTVRPRQLSRFLPPEDGGGRQSAVLILFGEGPRGPEILLQERAGTLRSHAGQPSFPGGALDPEDGDPHTTGPLRAALREAEEETGLDPAGVQLFGVLPRLYIPVSEFVVTPVLGWWREPSPVGPVDPAETARVFTVPVADLTDPAHRVTVVHPRGHQGPAFTVESALVWGFTAGVIDRILHYAGWERPWDRSRQVPLDWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY31</accession>
    <name>A0A0F4JY31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline D-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945790.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38638">
        <property type="protein sequence ID" value="KJY38638"/>
        <property type="gene ID" value="VR44_03085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7832"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="39295" checksum="B7426A5EEDF52997" modified="2015-06-24" version="1">MTANHHRPELQQAIQDIVDSGWAGVQLRVNDPRGEWVGSAGVAQMGGSAKPPTDGHFRIGSNTKSFTATLVLLLVADGRLELDGPVADHLPEYGLDPRITLRMVLQHTSGLFNFTGEYYEDGTTAPGIAWEGQEWVDNLLRTYRPEELVRLALSKPARFEPGTDWSYSNTNYVLLRLLVEKVTGRPFAEEMRTRILDPLGLSGTVVPDASPEIPEPHAHATYTYRHGDEWKTLDVTRSNPSWISAAGDMISTTRDLHVFFSALMGGRILPAGLLEEMRTPHPKLNYGLGLFVQQTEDGGTVYTHNGGMWGWGALMFSSPDGTTTLTASLTCGDARLDMMQVGELFGQAQKRLVAEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY50</accession>
    <name>A0A0F4JY50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000035">
        <property type="protein sequence ID" value="KJY39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39055">
        <property type="protein sequence ID" value="KJY39055"/>
        <property type="gene ID" value="VR44_02295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5724"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12460" checksum="D70D449B1C9773EA" modified="2015-06-24" version="1" fragment="single">RVVRDAVVLTDRRRLDRILTNLLVNAHKHGRPPVEVTVEGPVVVIHDHGSGYPAELVEQGPQRFRTGDPGRGRGHGLGLTIAAGQAAVLDIALSFANAPDGGALTTLRLPVGRLPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYB3</accession>
    <name>A0A0F4JYB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_02935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945758.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4896"/>
    <dbReference type="EnsemblBacteria" id="KJY38728">
        <property type="protein sequence ID" value="KJY38728"/>
        <property type="gene ID" value="VR44_02935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7319"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="8"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY38728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="43481" checksum="D10F2B1A8F10C6FE" modified="2015-06-24" version="1">MSPTNRTVVVTGIGATTPLGGDSASTWEGLLAGRSGVSPLEGERFAELPVRIAAQAAVDPGEVLPRPLARKLDRSAQFALIAAREAWADAGYTAPAGEDETIVPERLGTVIASGIGGVTTLLDQYDVLKEKGVRRVSPHTVPMLMPNGPSANVGLEVNARAGVHTPVSACASGAEAIGYAVEMIRTGRADVVVAGGTEAAIHPLPIAAFANMMAMSKNNESPTTASRPYDKARDGFVLGEGAGVVVLESAEHAAKRGARVYCEVLGQGLSADSHHIAQPEPTGRGVAAALQNLLDNTELDPSELVHLNAHATSTPQGDTAELKALRKVLGDDLDHVAISATKSMTGHLLGGAGGIETVATVLALYHRIAPPTINVDDLDDEVDADIVRGEARKLPVEGPIAAINNSFGFGGHNVSLAFRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ48</accession>
    <name>A0A0F4JZ48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ORF">VR44_01670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945523.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6512"/>
    <dbReference type="EnsemblBacteria" id="KJY39415">
        <property type="protein sequence ID" value="KJY39415"/>
        <property type="gene ID" value="VR44_01670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5735"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY39415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="863" mass="93942" checksum="AC2513A6C39F5336" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ99</accession>
    <name>A0A0F4JZ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat-shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945663.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39038">
        <property type="protein sequence ID" value="KJY39038"/>
        <property type="gene ID" value="VR44_02460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6782"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16871" checksum="74824075AE571D1C" modified="2015-06-24" version="1">MSGTQMERRRGLFPDLADWFGADFPRFPMWRPAPGIHPIPIEVTSNDGTYTLRAELPGLDPEKDVEITVDGDTLIVSAEHTESIEDKDHSEFRYGSFSRSVRLPGQIPTEGVEASYADGILTVRVPMKTEPPAGRRSIPVKRPQAPQAEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZA4</accession>
    <name>A0A0F4JZA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotran_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39043">
        <property type="protein sequence ID" value="KJY39043"/>
        <property type="gene ID" value="VR44_02355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6761"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="45"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="40209" checksum="DD146276BCA0FC29" modified="2015-06-24" version="1">MTDPTAPSAFPGGPALFRLDPAVAHLNHGSYGAVPLPVQEAQEALRAQAHADPDAFFNGVSERLTAARGRIAARLGADPDGLSFISNATEGANLALDAIPLAEGDEILVTDHGYGTVVEAAARRAKVTTVALDPRLPDEDAVREAVLAGVTPRTRVAVLDHVSSPTARLIAGPRLLAELAERGITTVVDGAHTPGMLAEPIAAGADFWFGNLHKWGYAPSGSALLAVAPAHRARVRALSPSWEDHRGFPLSVEYRATFDYTGWLAAPEGLDLLERLGADRVRAHNSALAGYGAELLARIPGMTVLPHTPGLALRSLLLPPGVAETREAATALREELAAKLRIRVLVWPRPGGGGLRVCGQVYNRAEEYERLAEALPAYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZA7</accession>
    <name>A0A0F4JZA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_00605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4820"/>
    <dbReference type="EnsemblBacteria" id="KJY39742">
        <property type="protein sequence ID" value="KJY39742"/>
        <property type="gene ID" value="VR44_00605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2827"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21848" checksum="049AEFA15B320209" modified="2015-06-24" version="1">MTTARRDTYTPETLLSVAVQVFNERGYDGTSMEHLSKAAGISKSSIYHHVAGKEELLQRAVSRALDELFAVLEEPGALRGRAVARVEYVTRRTVEVLVAELPYVTLLLRVRGNTRTERWALERRREFDHQVAELLKAAAADGDLRADMDIRLATRLLFGMVNSLVEWYRPHPGTTPDQLADAVVSMALDGLRTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZG9</accession>
    <name>A0A0F4JZG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000067">
        <property type="protein sequence ID" value="KJY38411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38411">
        <property type="protein sequence ID" value="KJY38411"/>
        <property type="gene ID" value="VR44_03690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6102" checksum="8E99B08E36C26AE8" modified="2015-06-24" version="1" fragment="single">MEVVIVPDAKAGGELIAEAMAALVRRKPDALLGVATGSTPLPVYEALAAKVAAGEVDASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K010</accession>
    <name>A0A0F4K010_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945819.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38616">
        <property type="protein sequence ID" value="KJY38616"/>
        <property type="gene ID" value="VR44_03220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7860"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102480">
        <property type="term" value="F:5-fluorocytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="44"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="46719" checksum="4936CE90E9302453" modified="2015-06-24" version="1">MIVRGARLLHEDGLHDVEVAEDGRIARVLPYDDQKEPPATGVLIEAHGGLLSAPFVEPHIHLDTALTAGQPRPNASGTLWEGIACWSERKRTLTREDVISRATEVLRWQAAQGVLHVRTHCDVTDPSLTALDALLEVRDRVREVMTLQITAFPQEGIVSFPDGEALLREAVARGADVVGAIPHFEDTREDGIASLRTAFALAEEHGLRLDAHCDEIDDEQSRFVEVLATLALRTGLRERATASHTTAMGSYNGAYAYKLQRLLSRSGIHLVCNPFANLNLQGRFDAYPKRRGLTQVKEMLAAGVNVALGHDDVMDPWNALGTGNPLQTALVGVYAAQLTGADEIPLAFSMVTERAARVLGLGADEYGVTEGAPASFVLLPAPTPGEAIRRQVRPRYVVSHGTVLAENPPAPARLWWPGQPGPSDVDFTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K019</accession>
    <name>A0A0F4K019_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945301.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39967">
        <property type="protein sequence ID" value="KJY39967"/>
        <property type="gene ID" value="VR44_00460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.91"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470999" evidence="2">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="27027" checksum="5496AA8A5E85F0A0" modified="2015-06-24" version="1">MRAGRARRAAAGAVSGLALAVLATGCGAGRPTVIVVEEGGPAAELPVSDPADGPARKGRQAGPAQKGRPQEAPERLLVAQGDLLDHKVTPEAHDSAPAGVDRPECRDLARAVEGFLPAGRTGWARASVVAVASALPDDASEGQKRAAALDAASSTVTVVTLGSYAAEAAHGHFAEVQAAGRACEGGYAATVNGETFTVTRVVPHAAYGGDEALAYTVEAERDGEPYQTELMVVRKGGTLVNFHASRLSGEAQLAAPAIEAQVRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0C4</accession>
    <name>A0A0F4K0C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945462.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39554">
        <property type="protein sequence ID" value="KJY39554"/>
        <property type="gene ID" value="VR44_01335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2983"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="4">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF35_N" evidence="3">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="235"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34043" checksum="E807A15D11202AE9" modified="2015-06-24" version="1">MTVDGTAAAAEVELLRRLRAFEGRPAAIAGRAKDPVNEPMIRHWCEAMGDTNPAYTGPEAIAPPTMLQAWTMGGLSGHTGRSTAYDELLALLDGAGCTSVVATDCEQEYLRPLRPGDTVTFDAVIESVSPRKTTKLGTGHFVTTRMDVHAGGELAGTHRFRILKYAPAARRPPSQPESAVKPQRPRPVINRDTQGFWDGIREHKLLIQRCTACATLRFPWLPGCNACSSPDWDTVEASGAGTVFSYVVMHHPPFPAFDPPYAVALVELAEGVRMISNIAGVPYDKVRIGLPVRLEFLRVDDTLELPVFRAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0R2</accession>
    <name>A0A0F4K0R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4794"/>
    <dbReference type="EnsemblBacteria" id="KJY39704">
        <property type="protein sequence ID" value="KJY39704"/>
        <property type="gene ID" value="VR44_00750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2855"/>
    <dbReference type="eggNOG" id="ENOG5033BI6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="58" mass="6589" checksum="1275D53690D6D2CD" modified="2015-06-24" version="1">MYGWIWRHLPGNAWVRALICLVLVLAVVFVLFQYVFPWAEPLLPFNDVTVDEGSGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1Z5</accession>
    <name>A0A0F4K1Z5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">VR44_00310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007265906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1030"/>
    <dbReference type="EnsemblBacteria" id="KJY39938">
        <property type="protein sequence ID" value="KJY39938"/>
        <property type="gene ID" value="VR44_00310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.60"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15807" checksum="010C8DB489742F9B" modified="2015-06-24" version="1">MLIPRRVKHRKQHHPKRSGMAKGGTEVSFGEYGIQALTPAYVTNRQIEAARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWIANVHPGRVMFELSYPNEKIAREALTRAAHKLPMKCRIVKREAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K297</accession>
    <name>A0A0F4K297_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_01735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945536.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39306">
        <property type="protein sequence ID" value="KJY39306"/>
        <property type="gene ID" value="VR44_01735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5749"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="144"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="33088" checksum="844ABBED8050091A" modified="2015-06-24" version="1">MAGFRIGRGRDDNRPPQQPPHTPRQQPYGQQQAPQAQAQAPYGHQPYPPAGGPPPQQHWPQPGGGAGGHGEPEYFDPYGGGPGGHHQQPHHPGAHEPSYADNPGHTQAFSLGEDPYGQATAYHAGAAAPAPAGPRLHWKDLLRGIVLRPGPTFLQMRDYAVWGPALTVTFVYGMLAVFGFDKARKDAIKATLTQVIPIVLSTGVAFVICGLILGAVTHTLARQLGGDGAWQPTVGLSMLVMSITDAPRLLVAVFLGGDNMFVQVLGWVTWLAAGALFTSMVSKSHDLPWQKALGASAIQLVALLSMIKLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K330</accession>
    <name>A0A0F4K330_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39561">
        <property type="protein sequence ID" value="KJY39561"/>
        <property type="gene ID" value="VR44_01260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2968"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="210"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="436" mass="46056" checksum="2CED958E7DB97D36" modified="2015-06-24" version="1">MQDRLAGMVSDLTTLHELTERLARASDLDSSLREFLRAGAALVGARRGLVVLEPSDGLGPTSTIGLGLGRADLGHIETVPRSATSYGRILDGLPDAHGGSEVLPEPGTAAIPGAGGYEPPADPRHREVAARLGYAASYALPLTADATGRLGAAVWLYDEQAEPSDRQRDLVGLYVRHAAEHLARMLEVDRSRTRLATVSEELLPSRLPRIPGVQLAARHRTGPLGGGDWYDALPLPESAMGLAVGSVTGSGPGAVAAMGRLRASLRAYAVMEGEDPVAVLSDLELLLRLTEPARSATALFAYCEPAARKIVLAGAGHTPPLLIGERRTEYVETSLSAPLGMLACWEAPSVEIEPASGETVLLYTDGLLRRTGDPMDRAYARLHAAAAGVPRSAREDPAAICDHILRTVLPEDGPHPAGSDPHRDTEDVVLLAARFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3H7</accession>
    <name>A0A0F4K3H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945324.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39736">
        <property type="protein sequence ID" value="KJY39736"/>
        <property type="gene ID" value="VR44_00570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2820"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="33430" checksum="3234F52A25B6752D" modified="2015-06-24" version="1">MHAITIEQPGGPEALVWADVPDPVAGEGEVLVEVAASAVNRADVLQRQGFYDPPPGASPYPGLECSGRIAALGPGVSGWAVGDEVCALLSGGGYAQKVAVPAGQLLPVPQGVDLVAAAALPEVVATVWSNVFMVAGLRPGETLLVHGGSSGIGTMAVQLGKAVGARVAVTAGGKEKLARCAELGADILIDYREQDFVEELKAATGGAGADVILDIMGAKYLGRNLEALAMNGRLAVIGFQGGVKAELDLRMLLAKRGAITATSLRARPLEEKAAIIAAVREHVWPLIDAGRVRPVVHASYPVTEAAEAHRVLESSAHVGKLLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I354</accession>
    <name>A0A0F4I354_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001822">
        <property type="protein sequence ID" value="KJY15898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15898">
        <property type="protein sequence ID" value="KJY15898"/>
        <property type="gene ID" value="VR44_40695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7076"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469144" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9079" checksum="8E6442FD19E5C7F0" modified="2015-06-24" version="1" fragment="single">DTTPHAVVRSRPFLLLAAAFTLSAFAVYAAVTTLVPLVTERGYTTSQAAWALGLGGAGQTLGRTLYASLARRTGATTRTVALITLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4G6</accession>
    <name>A0A0F4I4G6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001761">
        <property type="protein sequence ID" value="KJY16363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000047_gene2148"/>
    <dbReference type="EnsemblBacteria" id="KJY16363">
        <property type="protein sequence ID" value="KJY16363"/>
        <property type="gene ID" value="VR44_40490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20151" checksum="EA6A21AD70C35CC0" modified="2015-06-24" version="1" fragment="single">ALAHNPFNLREDLTDLDELAQSLTVRGQLQPLAVATRMAFMEAHPGATDGLGRAPYVVIDGNRRLAAAQLAGLKTMHIHVNDALSASAADILESALIANVHRVDVAPMDQARALQELVDVHGSQAQVAKRIGKTPAWVSQRLTLLNLTPDLQDKVESGELKVEPARRIGRLPQEQQAAAAAESINAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4N6</accession>
    <name>A0A0F4I4N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_40235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001705">
        <property type="protein sequence ID" value="KJY16925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16925">
        <property type="protein sequence ID" value="KJY16925"/>
        <property type="gene ID" value="VR44_40235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY16925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12415" checksum="9EE64C521D455754" modified="2015-06-24" version="1" fragment="single">MRADRLLSLLLLLQSRGRMTAPELAAELEVSVRTVYRDVEALGASGVPVCVDRGPAGGYRLMDGYRTRLTGLTDAEAGSLFLAGAPGPARDLGLGAVVATARLKLEAALPAALADRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IC78</accession>
    <name>A0A0F4IC78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001545">
        <property type="protein sequence ID" value="KJY19630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19630">
        <property type="protein sequence ID" value="KJY19630"/>
        <property type="gene ID" value="VR44_39040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5569"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="18706" checksum="A3EFB96C1CEEC1BA" modified="2015-06-24" version="1">MAAGVLAAIGLGIWGVTWARTGTEDPGKAKGRAEAKDKYTTLADCPAVAPFLPRLPGARDPAKDVHSETVTGAITSCSWAQERAAVASVDWDLELGRRGRSGTEEQRQRYTAAVTEGAGEPGIGDEAFWNGTCQLVVRDGNVMVTVWLNGGGSGTDACRPQVRDLARTALTVTQGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICQ3</accession>
    <name>A0A0F4ICQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001538">
        <property type="protein sequence ID" value="KJY19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952424.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001538.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19797">
        <property type="protein sequence ID" value="KJY19797"/>
        <property type="gene ID" value="VR44_38980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5554"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16097" checksum="61473AC99A4D03BE" modified="2015-06-24" version="1">MPKPLSPSSPSPLAHIQSLPSWLVGRVAARGRGLVADAIAGEGLKLMQHAVLAATAEYGPVAQAELGRRLAVDPKDMVGILNHLQDAGLVLRTPDPADRRKNAVTVTPQGEAALARCAALAEAANEQLLAPLTPGEQDVLMGLLRRVHEAPASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEM1</accession>
    <name>A0A0F4IEM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001567">
        <property type="protein sequence ID" value="KJY19111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952470.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001567.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene112"/>
    <dbReference type="EnsemblBacteria" id="KJY19111">
        <property type="protein sequence ID" value="KJY19111"/>
        <property type="gene ID" value="VR44_39230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5648"/>
    <dbReference type="eggNOG" id="ENOG502Z8QX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="29658" checksum="F2B3344D06663F5C" modified="2015-06-24" version="1">MPNTKKASKNQSKKNKSAVADEKGLDFPRAWVEFPDPADEEQVFRCDLTWLTSRWTCIFGSGCQGIQAGRASDGCCTLGAHFSDEDDEQRVAEHVARLTPELWQFHDVGSESGWTQLDDDGEKQTRRWDGACIFLNRPGFPAGAGCSLHILALRNGQEPLETKPDVCWQLPIRRTYEWIDRPDDTRVLQVSIGEYDRRGWGPGGHDLHWWCTSATSAHGAGEPVYVSYRAELTELMGAEAYAELVKLCEARLASLLPMAPHPADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIN8</accession>
    <name>A0A0F4IIN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001452">
        <property type="protein sequence ID" value="KJY21539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21539">
        <property type="protein sequence ID" value="KJY21539"/>
        <property type="gene ID" value="VR44_38245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="38592" checksum="3A84D2CF4717BC57" modified="2015-06-24" version="1" fragment="single">PLDALTDAPIGSAATPLALAGVHLSYAGDGGPAGDGAELTLRRLAVSDTPDGGAVPVAAPAAPAAPGAAATGGWQLAPPAQPRASGTPVLSPAAAGSTDLLRLRYWGGSGTEKGVQALLFPAPAAPPATPVPAVATTGYLRALGAATGDTVHITVDGVTVPLRITAAVEALPVAGRTALAVDLGTLGRLLLETAGQQPPAPTEWWLPAASAADPVPARAARALREGVRTERVQLSGEITAALLDDPLSAGPQSALAALAAACAVLAAIGFATSTAAERRVRGREFSVLLALGTPRRSLARAAAAEGAVLILLGTAVGTGLGVALVHLMAPLVVLTPAAHRPFPPVRVDMPFWQTLLTAAAIAAVPLLSAASGGPRGRDIAARLRPVEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILT6</accession>
    <name>A0A0F4ILT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001419">
        <property type="protein sequence ID" value="KJY22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952222.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001419.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22438">
        <property type="protein sequence ID" value="KJY22438"/>
        <property type="gene ID" value="VR44_37905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5141"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="546" mass="57934" checksum="036E14B89E57DA3F" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPM1</accession>
    <name>A0A0F4IPM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ECF subfamily RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001323">
        <property type="protein sequence ID" value="KJY23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952010.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001323.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23952">
        <property type="protein sequence ID" value="KJY23952"/>
        <property type="gene ID" value="VR44_36760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4662"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="21625" checksum="81DB7A22824F5855" modified="2015-06-24" version="1">MSEGEFDPSGDQTVSSELAGVLPVEFTAFHSQQHRAYLRYAHLQLGNAKDAEEVVDDVFTFLLKVWRQALKEASLHGFAWAVLREHVERRLAALGRQVAMVETAWFSALRRSSRERLELLESKLGLYAAIAELSERQYDVVLLAFLLGNDSDTVARMMGISPATVRSHVRGARRTLSRKLGVDWIPGEEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQF6</accession>
    <name>A0A0F4IQF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001335">
        <property type="protein sequence ID" value="KJY23904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952040.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001335.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23904">
        <property type="protein sequence ID" value="KJY23904"/>
        <property type="gene ID" value="VR44_36900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4696"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19428" checksum="2758C64A8DBA839F" modified="2015-06-24" version="1">MRNVSTLLLMTGHPPGPLWTGRASNRGQWLLAAAGAACLALGVELAVDNSWASGYVPLLMSVIGCLAAGLLILYGTLAFVYVAVTVDAEAMEVRCGHIGLPRRKIRLADVTAAEFLPRVTPQQWGGWGYRWRPEKGTAVIVRRGEGVELRLGDGKLFTVTVDDAENAVRVIRAHLRALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQP4</accession>
    <name>A0A0F4IQP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001318">
        <property type="protein sequence ID" value="KJY23979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23979">
        <property type="protein sequence ID" value="KJY23979"/>
        <property type="gene ID" value="VR44_36690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="454" mass="48120" checksum="BF398E57A4753AB2" modified="2015-06-24" version="1" fragment="single">RSWQRVPAARRARGGGPVVPVVGLASGSLGRLVRVVSGDGRWRRLACLRLDAAAAAAPAPAAAPPHRDADPLELVERFRAGASPTAQRLAAHLAAVPLTLPVMTLVRRSLLRGSEHGHLAEVALGGLLAPWQGQQRPEEVEFEFLPGVREVLLGSQLRGDVAEVRELVRRRVWEYMARNRGTGPDFSATRVTTGTEGRRPVPEGARPFAERGPAVEREPAGETEPLADRARAADREHALDRGPVADREPVADQDPVVDREPVAAAVADRGPVGGVVRVGFDSFREPGEVGILLAPRLVLTAGQVAAPGGAAVWVRAGGREFPCQPVWRDDASPPVLLLESERDLTDPAGFVPQPWGRPPAPGGVRLRVDGVTEGGQPAALTGTLVHDDGAANGELVDLSPEPETWTHFVGAPVSDGGRLIGVVHTVHRDRLVFLTAAALLEQPAFRSALDGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRG2</accession>
    <name>A0A0F4IRG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001260">
        <property type="protein sequence ID" value="KJY24259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2780"/>
    <dbReference type="EnsemblBacteria" id="KJY24259">
        <property type="protein sequence ID" value="KJY24259"/>
        <property type="gene ID" value="VR44_35895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4336"/>
    <dbReference type="eggNOG" id="COG4214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="38648" checksum="2A343E215FC04457" modified="2015-06-24" version="1">MLLALALIVLLFQFWTGGILLQPLNITNLIQQNGYILILAIGMMIVIIAGHIDLSVGSLAAFVGAAAAVMMVEHRTPWPLALAVALLLGALAGAWQGFWIAYLGVPSFIVTLAGMLLFRGGTQILLQGQSVAPFPKGFQNISSGFLPEVGPRTDYHNLTLLLGLAVLAVAVLQEVRRRRRAVSYGLRPLPAGLFLVKLGAIAAAVVTFTLLLASYHGAPIVLLLLGVLLAVFGYVMRNSVLGRHTYAIGGNEAAARLSGVKSKRVVFLAFVNMGVLAALAGMVFAARLNAGTPQAGINFELEAIAAAFIGGASASGGVGTVLGALTGGLVLGVLNNGMSLVGVGTDYQQVIKGLVLLAAVGFDVYNKRKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRS5</accession>
    <name>A0A0F4IRS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001240">
        <property type="protein sequence ID" value="KJY24369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24369">
        <property type="protein sequence ID" value="KJY24369"/>
        <property type="gene ID" value="VR44_35580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CO_deh_flav_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8400" checksum="4982CC4428B8B9BB" modified="2015-06-24" version="1" fragment="single">VLTSVRLPAALPGERAACHRAISRARAEWPLVEAVARLALQGSVITRAAVAAGGVARVPLRLPEVEAALTGREATPGVLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS64</accession>
    <name>A0A0F4IS64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_35710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001249">
        <property type="protein sequence ID" value="KJY24323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951810.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001249.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3787"/>
    <dbReference type="EnsemblBacteria" id="KJY24323">
        <property type="protein sequence ID" value="KJY24323"/>
        <property type="gene ID" value="VR44_35710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4293"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="176"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="352"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="429"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="568" mass="62908" checksum="662623780F7297FA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISI4</accession>
    <name>A0A0F4ISI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001193">
        <property type="protein sequence ID" value="KJY24619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2566"/>
    <dbReference type="EnsemblBacteria" id="KJY24619">
        <property type="protein sequence ID" value="KJY24619"/>
        <property type="gene ID" value="VR44_34800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4031"/>
    <dbReference type="eggNOG" id="ENOG502ZT33">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="55" mass="5927" checksum="BFD96FBDD0441D30" modified="2015-06-24" version="1">MSLSTTANNLVLLASEGAEQHGGNHESLSPYLTGGGALFVLLLMLWVTTRLNRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISR6</accession>
    <name>A0A0F4ISR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001129">
        <property type="protein sequence ID" value="KJY25050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951430.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001129.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25050">
        <property type="protein sequence ID" value="KJY25050"/>
        <property type="gene ID" value="VR44_33630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3633"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27344" checksum="5D0A070E34BB3B5A" modified="2015-06-24" version="1" fragment="single">GELVIGVGALPAGFPPLAYTGTDQKTLTGAEPDLGRLVAATLGLKPVVKNSTWENLFVGVDSGKVDAAFSNVTVTEERKKKYEFASYRKDNLAFEVLKENPWNFGGDFHNLAGKTVAVSKGTNQEKILLEWQGKLRAEGKDVEVKYFPDPNSVYLALSGGKIDLSFGPNPSIAYHITQTAGGNAPTRNAGSYSGAGESLQGLIAATAKKDSGLAKPVAEAVNHLIRNGQYAQLLAAWNLSNEAVTTSEVNPPGLPQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IST5</accession>
    <name>A0A0F4IST5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor SigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_33530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001125">
        <property type="protein sequence ID" value="KJY25070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5686"/>
    <dbReference type="EnsemblBacteria" id="KJY25070">
        <property type="protein sequence ID" value="KJY25070"/>
        <property type="gene ID" value="VR44_33530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3586"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24434" checksum="C3A5219F7B7273CB" modified="2015-06-24" version="1">MTYTADRFHTAHTATTATFAADAGSQAWTPPTWEEIVSTHSARVYRLAYRLTGNQHDAEDLTQEVFVRVFRSLSTYTPGTFEGWLHRITTNLFLDMVRRKQRIRFDALADDAAERLPSREPSPQQVLHDTHFDADVQQALDTLAPEFRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRSHLRKALKHRSPEARASQRALAGVAVGVPGAGGEGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT77</accession>
    <name>A0A0F4IT77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein meaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_33095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001107">
        <property type="protein sequence ID" value="KJY25210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951329.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3635"/>
    <dbReference type="EnsemblBacteria" id="KJY25210">
        <property type="protein sequence ID" value="KJY25210"/>
        <property type="gene ID" value="VR44_33095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3491"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="9">
        <location>
            <begin position="544"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY25210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="683" mass="74649" checksum="FABBC4D9B54244FD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT80</accession>
    <name>A0A0F4IT80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_33120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001107">
        <property type="protein sequence ID" value="KJY25215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951333.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3640"/>
    <dbReference type="EnsemblBacteria" id="KJY25215">
        <property type="protein sequence ID" value="KJY25215"/>
        <property type="gene ID" value="VR44_33120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3496"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY25215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="30059" checksum="BC83E7DCDD50F1D5" modified="2015-06-24" version="1">MTDPETPATGWVPESAPEESAEDDMPLSLRLSIADTLTLGNATCGFMAVYFTTTGILIPHLTGSGESGMARHSAATAVILMLLAAVFDLFDGIVARKLRSSPMGAELDNLSDLISFGLAPAYFVLVYGMVADDAHQKVSALAAIVVLLAVVLRLARFSCVTMKDGMFQGMPSPFGALTVVSIVLLELPFVPTLLAIVGVAWLMVSRVEYPKPRGVLAAAMLSWIVGAMGLLAAWAFDAPGGQLLLQTGCALQIALAATIPLFATTRRANTFRHNRREARAAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITB5</accession>
    <name>A0A0F4ITB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001151">
        <property type="protein sequence ID" value="KJY24899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24899">
        <property type="protein sequence ID" value="KJY24899"/>
        <property type="gene ID" value="VR44_34025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3731"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24500" checksum="E9BC926DE86C04CD" modified="2015-06-24" version="1">MDDHFTEALLVLRRFVGVPLPATDWRIRALVRPDGEHIRIRLADAAGQNVLVDLPTSFGRKHGSWWYVGALRRTAGGLAVGTVPVAAERQGIPYVDVAELVGSVVPEAAEVTLDDGIDYLVADLAGDPLWHGATPSAAPELYVLTGFDYHHPGVVRVYLDHEGRTIGVDLPLSDDGRLRPVQWWASTKLIALLNPEEPTTLAAHQTHDAHDPLCEAVYDLTEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITM1</accession>
    <name>A0A0F4ITM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_34205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001163">
        <property type="protein sequence ID" value="KJY24828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951534.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001163.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24828">
        <property type="protein sequence ID" value="KJY24828"/>
        <property type="gene ID" value="VR44_34205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3812"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="232"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="437" mass="43846" checksum="1D04D99B4AD3093B" modified="2015-06-24" version="1">MTSSYTGGSASSRRRTPLGALVAASGISSLGMAATLVAVPWFVLHSTGSGTRTGLVATAEVLGLLCSAVLAGPVVDRLPVRATSVGADLLTASAIGLIPLLHAWGALPLPVLIVLVFLVGAARGPSDTSKQLLLPGAMERAGVTAERATGAVEGARRIGMMAGAPLAGLLISTAGPVRTLFADLAAMAACALVVATLVPATARPRPVADGPRGSYTQELRFGIGQLRKDRLLGAMVGVLMLTNALDGALNGVLYPAYGTRVLRSSALFGAMVTAMGAGALLGAALYGWAGHRLPRRAVFVGAFVLVGAVRCAALAAEPGATVLLAVLALSGIGSGIVSPLMMSVAYERVPEAVRGRVFGLLVAAALAATPLGMLGAGLALDAAGLVPALLGTGALYLTVTLAPLVFPVWRELDSRAPAERAEPPAELRSAAPAVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW4</accession>
    <name>A0A0F4ITW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001122">
        <property type="protein sequence ID" value="KJY25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951400.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001122.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5151"/>
    <dbReference type="EnsemblBacteria" id="KJY25094">
        <property type="protein sequence ID" value="KJY25094"/>
        <property type="gene ID" value="VR44_33450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3570"/>
    <dbReference type="eggNOG" id="COG3200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="49670" checksum="24774C53123D8396" modified="2015-06-24" version="1">MTVNAENHALAAKATWRDLPAAQQPSYPDAEALRAVVADLESYPPLVFAGECDQLRARLGAVAKGEAFLLQGGDCAEAFDAVSADHIRAKLKTLLQMSAVLTYAASVPVVKVGRIAGQYSKPRSKDTETRDGVTLPTYRGDSVNGFAFTEEARVPDPERLKRMYHASASTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPSGQRYEQLAREIDNALNFMKACGTDPAEFKAVEFYSSHEALLLDYEGALTRTDSRTGKLYDTSGHMVWIGERTRQLDHAHIEFCSQIANPIGIKLGPTTTVDEALTYIDRLDPEREPGRLTFVVRMGADKVRDKLPELVDKVTASGATVAWVTDPMHGNTFEAASGHKTRRFDDVLDEVKGFFEVHKALGTHPGGIHVELTGDDVTECVGGGDEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW7</accession>
    <name>A0A0F4ITW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001073">
        <property type="protein sequence ID" value="KJY25442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951223.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25442">
        <property type="protein sequence ID" value="KJY25442"/>
        <property type="gene ID" value="VR44_32500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3304"/>
    <dbReference type="eggNOG" id="COG3360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="8007" checksum="5C0D7D02FB26811D" modified="2015-06-24" version="1">MSNHTYRVTEIVGTSHEGIDQAIRNGITRAGQTLRNLDWFEVTQVRGHIENGQIAHYQVGLKVGFRLDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITX3</accession>
    <name>A0A0F4ITX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001071">
        <property type="protein sequence ID" value="KJY25455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951212.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25455">
        <property type="protein sequence ID" value="KJY25455"/>
        <property type="gene ID" value="VR44_32445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3293"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="31398" checksum="DFD233DBC50D47E3" modified="2015-06-24" version="1">MQFQQLVYFVAVAETRHFTRAAEREHVAQPSLSQQIKALERELGAELFSRARGNIALTDAGEALLPLARRILADADTARLEVQELLQLRRGRVRLGATPSVCTGMLPEVLRAFHTAHPGIELLIEEGGSLDLVRELARGVLDLALIVLPLPPSAPPLTTVELLTEDLVVVSSRELPPPGGGGELTIADLREEPMVMFRHGYDLRDLTVGACRAAGFEPVFTVEGGEMDAVLGFVRAGLGVAVVPEMVVAHAGPGLRATPLTGSPLRRTIALAHRTDVAPPRAARELKRILVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU42</accession>
    <name>A0A0F4IU42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_32270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25530">
        <property type="protein sequence ID" value="KJY25530"/>
        <property type="gene ID" value="VR44_32270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="222"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="38494" checksum="3D88ADEF228E8835" modified="2015-06-24" version="1" fragment="single">MKRSYTWTVGHTPWSAWAWRNTAFSVAAIPPALPVATGLLLLTVAAPGRTALPLLLCLALSPLLTKLQRSRFRVLLGLDVPPVVHTHPWRTVRGLSERLRSEATRRQYAYHLAVSPLAALGAGLLVLTWACGLAGASAYAWVWMLPSDGELPDFGWTRQYDLLTVGGALMLLAAPWMAALLTRLDALAAASLLGPNRARELQRRVEDLAESRAGVLDAADIERRRIERDLHDGAQQRLVSLAMNLGIARATLQDLPPEAKAVIDEAHREAKEAIEELSNLVRGLHPAVLEDRGLDAALSGIAARAPLPVELTVDLAERPGPTVEAVAYFVVSEALANVAKHARARRCSVTVARVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW76</accession>
    <name>A0A0F4IW76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000957">
        <property type="protein sequence ID" value="KJY26295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26295">
        <property type="protein sequence ID" value="KJY26295"/>
        <property type="gene ID" value="VR44_30365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2485"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12229" checksum="7B1CCE3DFD80D2A9" modified="2015-06-24" version="1">MPVAHRPARSLRVLLDPPNPPLAVRLGLQPDIEVVASPAERPVVALVEDPASVAALLAEDPECRVLVATGSAHPGLRESVLAAGAAGLVLRDGPVEELAECLRRASMGETVVDPALAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWE9</accession>
    <name>A0A0F4IWE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_31190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001007">
        <property type="protein sequence ID" value="KJY25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950975.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25939">
        <property type="protein sequence ID" value="KJY25939"/>
        <property type="gene ID" value="VR44_31190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2726"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469895" evidence="6">
        <location>
            <begin position="33"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="47"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="566" mass="59725" checksum="76F130D17FBD4B4D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWF5</accession>
    <name>A0A0F4IWF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001137">
        <property type="protein sequence ID" value="KJY24996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951448.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001137.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24996">
        <property type="protein sequence ID" value="KJY24996"/>
        <property type="gene ID" value="VR44_33735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3662"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="27328" checksum="03D5DCBDF7FC0A62" modified="2015-06-24" version="1">MFGRNTRDEPFEAVHWDEITQFTVGRTMRNTFRKSKRGEGAHAVRSMRMRGGEEYMVPGVYIVPVELSASLAKGGFRLFEDEAGRQLLCTVLPDGSDRYRVKDHADREIGCIRRTPVTKRLTRQGLWMEQPGYPSVVAPRAWARGGPGASLGRGVGHVLDGIVDSLLSFGSDEAGGSGGLKPVVWAAVVEDAGEEADGEYGEAVLTFPRRTDGTRWYFVKRDGWLDKRLAFALAVLRESDTIGADRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXG1</accession>
    <name>A0A0F4IXG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000908">
        <property type="protein sequence ID" value="KJY26725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26725">
        <property type="protein sequence ID" value="KJY26725"/>
        <property type="gene ID" value="VR44_29335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2231"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469922" evidence="2">
        <location>
            <begin position="36"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="47"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="588" mass="59516" checksum="940812F3A6540F24" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXM2</accession>
    <name>A0A0F4IXM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000942">
        <property type="protein sequence ID" value="KJY26409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26409">
        <property type="protein sequence ID" value="KJY26409"/>
        <property type="gene ID" value="VR44_30110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2425"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_4" evidence="2">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="30156" checksum="A5A1B064BD89BFC4" modified="2015-06-24" version="1" fragment="single">SYGTQLDGVYAHLFPKNVGRTVFDAVVDPTSDELQADLGQAKGFQQALEHAMEYCRDKYAANCPTGGSADEGNRRIADLLKKLETEPAPTKSARKLGSDLALTGIAASLYDEKTWDYLVQSLGELRQRGTGNNLLAIADAYSGRGADGHYNNTDAAHTAISCADTSRRYTVAEMRAQEPAFRSASPVFGPSMAKGLLVCTDWPVRGASDKPQVAAEGAAPILVVGNTGDPATPVEGAKRMADALGRGVGVNLTVKGEGHGVYGSNACATKAVDAFLVDGTAPADGTVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXW8</accession>
    <name>A0A0F4IXW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Alpha-amylase</fullName>
            <ecNumber evidence="4 9">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_29970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="JZWV01000935">
        <property type="protein sequence ID" value="KJY26484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950757.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000935.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26484">
        <property type="protein sequence ID" value="KJY26484"/>
        <property type="gene ID" value="VR44_29970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2376"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469933" description="Alpha-amylase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="466"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="568" mass="60538" checksum="05CD7FC879D43B21" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY77</accession>
    <name>A0A0F4IY77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001044">
        <property type="protein sequence ID" value="KJY25631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951133.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25631">
        <property type="protein sequence ID" value="KJY25631"/>
        <property type="gene ID" value="VR44_32020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3121"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031016">
        <property type="entry name" value="CGA_synthase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04467">
        <property type="entry name" value="CGA_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="40300" checksum="4D95747C5047517C" modified="2015-06-24" version="1" fragment="single">MPPIPALNSATPSDPPGAATVALVGAEFGWGSSGKLSAVLSALRDRPAPPLRFVGMGSGLGRPLLAEHPVDGWYDLPDDPGRAGPWVAEFVRSQGVRAAVVVLDGAAARALLAAGVPTVFVDSLPFLWSEGDRAALPLDATVYCAQKSVELPPECRSVLADARGLRWVEAVIARPRAAQPERGAPRSAGRPYRRALISLGGLRAPNLLAPEHYPRLVLPAALEALAAHGVEEVHIAGNLPGGLVGGLVDSCAAAPRTTAGPLGHGAFLERLDACDVLLTSPGLTTLLEAGGLGVPTVCLPPQNLSQIFNGRYHSQALGARLRVLWPKEVLVEDEVLALRAKGEDHALERIYGAIGAAARGDSRQEVGRALREGVLDALRRSAGVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYB4</accession>
    <name>A0A0F4IYB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000939">
        <property type="protein sequence ID" value="KJY26443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950776.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000939.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26443">
        <property type="protein sequence ID" value="KJY26443"/>
        <property type="gene ID" value="VR44_30060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2396"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12412" checksum="2905463C54EB3EA8" modified="2015-06-24" version="1">MNTSDRDSGTDPEAIDENVIAELARLRDSIDNIDAAVVHMLAERFKCTQQVGHLKARHHLPPADPGREASQIARLRQLAENAKLDPAFAEKLLNFIIAEVIRHHETIAAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYI5</accession>
    <name>A0A0F4IYI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin system, toxin component, RelE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001030">
        <property type="protein sequence ID" value="KJY25741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951078.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25741">
        <property type="protein sequence ID" value="KJY25741"/>
        <property type="gene ID" value="VR44_31725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3055"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="13849" checksum="B1DA162BA62662F1" modified="2015-06-24" version="1">MEDLFTVEIEPEVRLWLMNLSDADYLVAEHAVGLLVDAPTTLGEPYSRHLGGGVRELRFILGHNREAVRLSYRLAPHRRIVLLTVFRKTKQREVAEVDRAVRAGRVCESSHGPAVDVYTRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ24</accession>
    <name>A0A0F4IZ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000854">
        <property type="protein sequence ID" value="KJY27257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950401.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000854.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene227"/>
    <dbReference type="EnsemblBacteria" id="KJY27257">
        <property type="protein sequence ID" value="KJY27257"/>
        <property type="gene ID" value="VR44_28025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1856"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="27912" checksum="8AAA5279A7E8B0B9" modified="2015-06-24" version="1">MSSLLLLTNALQPSAEVLPALGLLLHNVRVAPAEGPALVDTPGADVILVDGRRDLPQVRSLCQLLRSTGPGCPLILVVTEGGLAAVTADWGIDDVLLDTAGPAEVEARLRLATGRQQLGSDDSPMEIRNGDLSVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVTPEKVERAAAEAAAKAERKKAPAAETPAEAPAETPSAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZB9</accession>
    <name>A0A0F4IZB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000843">
        <property type="protein sequence ID" value="KJY27375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950356.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000843.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27375">
        <property type="protein sequence ID" value="KJY27375"/>
        <property type="gene ID" value="VR44_27775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1793"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6727" checksum="E6CD14FB032B311A" modified="2015-06-24" version="1">MTLDDLYTDIVAEEFDADADTGPYREAVLALAVLGAVADGETGEEVRTTARALGARLGMRLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0E2</accession>
    <name>A0A0F4J0E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000945">
        <property type="protein sequence ID" value="KJY26391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950795.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000945.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26391">
        <property type="protein sequence ID" value="KJY26391"/>
        <property type="gene ID" value="VR44_30180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2441"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="175" mass="17869" checksum="E6D7D7B2ED620988" modified="2015-06-24" version="1">MSAAADARQAGARVEEVLDRLAASGDRAACAAAEELVRVLMEFYGAGLARITERLGAGSLAPLLDDDLVASLLTLHGLHPEDVHTRVERALRAAGAPVEPLGFDEATGVLRLRTAPATASGCGCGTGGTDATRAALEDALACFAPEVTGVDIETAAPPPPLLQIGTRPQTPARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J106</accession>
    <name>A0A0F4J106_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000819">
        <property type="protein sequence ID" value="KJY27564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950262.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000819.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27564">
        <property type="protein sequence ID" value="KJY27564"/>
        <property type="gene ID" value="VR44_27245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1585"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="466" mass="49890" checksum="2DD2BAB9B87E8079" modified="2015-06-24" version="1">MPIATVNPTTGQTLRTFDALDADGIERCLDEAARTAVTYRRTGFAERAALLNRAADLLEAEGEDIARTMTVEMGKPLAAARAEAAKCVKAMRWYAANAEGLLADERPADSDVRDAGASAVRVRYRPLGVVLAVMPWNFPLWQVVRFAAPALMAGNVGLLKHSSNVPQTALYLGDLFRRAGFPEGCFQTLLIGSGPVEGILRDPRVAAATLTGSEPAGRAVASVAGDEVKKTVLELGGSDPYIVMPSADIARAAKTAVTARVQNNGQSCIAAKRFIVHTDVYEEFARLFTEGMTALTVGDPMRESTDVGPLATESGRADVEELVDDAVRQGATVLCGGRRPPGHPDGWFYEPTVLADVTPEMRIDLEETFGPVATLYRVGSLDEAVERANHTPFGLSSNVWTRDEADLDRFVQELEAGGIFVNGMTASHPALPFGGVKRSGYGRELSGHGIREFCNITTVWQAADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J148</accession>
    <name>A0A0F4J148_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">VR44_27440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030846240.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000831.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5369"/>
    <dbReference type="EnsemblBacteria" id="KJY27458">
        <property type="protein sequence ID" value="KJY27458"/>
        <property type="gene ID" value="VR44_27440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1656"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27576" checksum="5D8127FE49F57D18" modified="2015-06-24" version="1">MATLEIHDLHVSVEAENGAREILKGVDLTVKQGETHAIMGPNGSGKSTLAYSLAGHPKYTITGGTVTLDGEDVLEMSVDERARAGVFLAMQYPVEVPGVSVSNFLRTSATAIRGEAPKLRTWVKEVKSAMEQLQMDPAFAERNVNEGFSGGEKKRHEILQLELLKPKIAILDETDSGLDVDALRIVSEGVNRVRETGEVGTLLITHYTRILRYIKPDFVHVFANGRIAESGGAELADQLENEGYDKYVKGGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J198</accession>
    <name>A0A0F4J198_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000827">
        <property type="protein sequence ID" value="KJY27508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27508">
        <property type="protein sequence ID" value="KJY27508"/>
        <property type="gene ID" value="VR44_27355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1613"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="20281" checksum="1775899BA466B4E5" modified="2015-06-24" version="1">MPRPRLPGGYAASGVRAVRVTLVAAAGFYLFLYGFGAPTAATYALFSAVALAGLSRIPGTGPQRAATVLRLAPVCWLLVVVGTYLSVRTWTAVAGMLVIGFALAFAAVGGPGLAGAGPGLQLLYILPSFPPYDPGSLGVRLVGTTTGLALLVLAERYLFPEPAPPSYQELAARAADTAAHCARELGAPPYALGPAAAGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1W7</accession>
    <name>A0A0F4J1W7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="5" type="ORF">VR44_26935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000804">
        <property type="protein sequence ID" value="KJY27723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3053"/>
    <dbReference type="EnsemblBacteria" id="KJY27723">
        <property type="protein sequence ID" value="KJY27723"/>
        <property type="gene ID" value="VR44_26935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1549"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="190"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="518"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="658" mass="73150" checksum="B7A1AFBAE11C4489" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1X7</accession>
    <name>A0A0F4J1X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000790">
        <property type="protein sequence ID" value="KJY27869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950133.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000790.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27869">
        <property type="protein sequence ID" value="KJY27869"/>
        <property type="gene ID" value="VR44_26555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1436"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="36552" checksum="6D5F00280C2116C0" modified="2015-06-24" version="1" fragment="single">MTDVLLLAGTRKGLFIGRRRDSGPWEFDGPHFNAQAVSAVAIDARGPVPRLLAGGDSAHWGPSVFRSDDLGASWQEPAAPAVKFPKDTGASLERVWQLHPAGPEAPGVVYAGTEPAALFRSADRGESFELVRPLWEHPTRSAWVPGGGGEGLHTVITHPADPAALTVAVSTAGVFRSRDGGASWRPSNHGVSAVFLPDPHPEFGQCVHKIAQDAGDPDRLYLQNHWGVYRSDDAGAEWTDIGSGLPSDFGFAVAAHPHRPDTAYLFPLNADSDRVPAGHRCRVFRTRDAGATWEPLTKGLPEGDHYGTVLRDALCTDDADPAGVYFGNRNGELYASDDDGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J253</accession>
    <name>A0A0F4J253_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950519.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26986">
        <property type="protein sequence ID" value="KJY26986"/>
        <property type="gene ID" value="VR44_28670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2065"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470058" evidence="2">
        <location>
            <begin position="34"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="25695" checksum="2959D6BE690011A1" modified="2015-06-24" version="1">MRITARFKAPATTFALLPALLLGAVGCSSGTDAAAPAKSPDPKGSAAAAPSGAPGPAASPAPKAKDARLERSALEQGDLPGYQVSAQGKNPSAPTGQPQADKKACQPLADIMGDKPDPAAHETVNRGIGSQKQVGLAVSASVSSYDESDAKKVVSRLREAVAACGSGFTATVQKQTGTYRDVKAVPFRTAGDESVSWTTTAAAEGVSAQVHLVVVREGSSVVRLMALNVAAAGQKAAVPQEVADKQLEKVRKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Z7</accession>
    <name>A0A0F4J3Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000678">
        <property type="protein sequence ID" value="KJY29077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949620.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000678.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29077">
        <property type="protein sequence ID" value="KJY29077"/>
        <property type="gene ID" value="VR44_23815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.736"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13560" checksum="3BEBB7D1697AC120" modified="2015-06-24" version="1">MTRTRITDGVLHTTLADVARFLRHLLSPAGHPVPRAWTDESLRIRTGELTPSRGLLWHPAPAGVWAHHPPSGPGPALWIAPRHDRWAVLLPGPATGSGTLLRTAFREAAFAREDLTAPALTGGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4B4</accession>
    <name>A0A0F4J4B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950174.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3176"/>
    <dbReference type="EnsemblBacteria" id="KJY27776">
        <property type="protein sequence ID" value="KJY27776"/>
        <property type="gene ID" value="VR44_26775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1513"/>
    <dbReference type="eggNOG" id="COG2149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14644" checksum="6C8255C3BF43D7E4" modified="2015-06-24" version="1">MIDFVKDVRLWFAPQRLRAEGETPDYRFSLANERTFLAWIRTALALVGGGFAVDQFLPDLRWGVRVGMALALLAVGAACALRAVHHWVRCERAMRRGEDLPLSPFPVLLSLGVGLVAVAMMVVVLLGWTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J529</accession>
    <name>A0A0F4J529_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949455.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29457">
        <property type="protein sequence ID" value="KJY29457"/>
        <property type="gene ID" value="VR44_22895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.513"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6587" checksum="096ABFC2A55384E2" modified="2015-06-24" version="1">MAKIAAFMNEQEMGPITESVVNRDGTPVMATPAAVVAVPASVKITAAVVAFTVPVGAYVAGRVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J538</accession>
    <name>A0A0F4J538_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxic cation resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949707.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28878">
        <property type="protein sequence ID" value="KJY28878"/>
        <property type="gene ID" value="VR44_24270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.834"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26232" checksum="013966A58F07AC5D" modified="2015-06-24" version="1">MTGGAGAISLRKVEETAPALVPLYKSAGVSLRKHGLEGGRAAVYLVLDHSGSMRPYYGDGTVQAFADRVLGLSAHLDSDGRVPVVFFSTDVDAIEEVPLAAHEGRVTQIAAGLGHMGKTAYHLAMDAVIDHYLDSGSTDPALVVFQTDGGPVNKLAAEKYLCKAARLPLFWQFVGFGNTRSSQFDFLRRLDELPVPQKRVVDNAGYFHAGPDPRAVPDAELYDRLVAEFPAWLAAARRAGIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5H8</accession>
    <name>A0A0F4J5H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949616.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene189"/>
    <dbReference type="EnsemblBacteria" id="KJY29094">
        <property type="protein sequence ID" value="KJY29094"/>
        <property type="gene ID" value="VR44_23790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.731"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="34221" checksum="E30E5A37F72E441F" modified="2015-06-24" version="1">MAGNSQRRNRRTSNKKGATVGSGGQRRKGLEGKGPTPKAEDRKGHKAFRISNAMARQAAKRRPAPRRGGPKGTSEMVVGRNPVFEALRDGVPATTLYVQQFIDNDERVRDALKLAGERGNINLMEAPRAELDRMTNGLNHQGLVLQVPPYEYAHPEDLTDAAYDNGEDPLIVALDGVTDPRNLGAIVRSVSAFGGHGVVIPERRAAGMTAGAWKTSAGTAARTPVSRVTNLTRALQEYKKAGIAVVGLAAEGTHEVQDLDALAGPVVIVVGSEGKGLGRLVGENCDYLVRIPMPGGAESLNAGVAAGVVLYEAARRRATQGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5V4</accession>
    <name>A0A0F4J5V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949320.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5166"/>
    <dbReference type="EnsemblBacteria" id="KJY29742">
        <property type="protein sequence ID" value="KJY29742"/>
        <property type="gene ID" value="VR44_22165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.317"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21175" checksum="41895D9D18F3DC17" modified="2015-06-24" version="1">MSVLPLVFTSGWASGINAYAVVLLLGIFGATGLTDEVPASLQRTDVLVVAGVLFLCEAVADKIPYVDSVWDSVHTVIRPATGAVVGALLAGQSGSLPDIAAGALGGSTALASHLVKAGTRMAVNTSPEPFSNILLSFAEDLGVAGLVVFAVFHPTAAAVIAAVLLAAGLAIVVFLWSRIRRFRRRRAQRREEKRTAAVQGAPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J658</accession>
    <name>A0A0F4J658_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">VR44_23285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000655">
        <property type="protein sequence ID" value="KJY29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949522.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000655.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3046"/>
    <dbReference type="EnsemblBacteria" id="KJY29319">
        <property type="protein sequence ID" value="KJY29319"/>
        <property type="gene ID" value="VR44_23285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.597"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="18"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="33977" checksum="AA6AE90351B3FBCA" modified="2015-06-24" version="1">MTNPQPLLPPHARVFVAGHRGLVGSAVVRRLTADGHEVLTRGRADLDLRDAAATEAYLRDVRPDAVVLAAAKVGGIMANSTYPVQFLEDNLRIQLSVIGGSHAAGVGRLLFLGSSCIYPKLAPQPITEDALLTGPLEPTNEAYALAKIAGIVQVQSYRKQYGASYISAMPTNLYGPGDNFDLESSHVLPALIRRFHEAAAEGREEVTLWGSGTPRREFLHVDDLAAACAVLLERYDGDEPVNIGCGEDLTIRELAETVAEVTGFAGRLDWDTSKPDGTPRKLLDVSRLTALGWKPGIGLREGIASTYRWWLDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7B5</accession>
    <name>A0A0F4J7B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthesis protein ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949155.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30065">
        <property type="protein sequence ID" value="KJY30065"/>
        <property type="gene ID" value="VR44_21305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8986"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="129"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="370" mass="38135" checksum="FAE90FFC7DD5F69B" modified="2015-06-24" version="1">MYPKVKPALARAWRDLQTVQFGVTPAHAVVLGPVDTATGSLIDRIDGTRGMELLRAEARGMGLPEGQADGLVRRLAGAGLLDDATAGGPRAQAVRSRPEALERLGPDLGSLSLVHPEPGGDLRGVAARRAIRVRVRGSGRVGALVAAVLAGAGVGRVEVLDGGRVEPADVAPGGLGPGSVGRLRAEAARALVRESAPGRAPREGDPEGPGPEVALVVVTPRDGLQAWAPDPATAADWVATGTPHLYAGVLEGTGLVGPLVLPGVTACAGCMERERVDGDPAWPRMLVQWRTAHRRRERAACDLGLSTAVAGLAAAHALAFLDGRLPASTGSRWEAALPALHWERSELSPHPECPCGASVLAADPALEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7J6</accession>
    <name>A0A0F4J7J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_20625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949031.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6940"/>
    <dbReference type="EnsemblBacteria" id="KJY30372">
        <property type="protein sequence ID" value="KJY30372"/>
        <property type="gene ID" value="VR44_20625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8840"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="369"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="477" mass="51689" checksum="6932730208932817" modified="2015-06-24" version="1">MTAKPRIPNVLAGRYASAELAVLWSPEYKVTLERRLWLAVLRAQKDLGIEVPDAALADYERVLETVDLASIAEREKVTRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRLSLELARDRTVAVLARLGKLAGEHAELVMAGRSHNVAAQATTLGKRFATAADELLVAYDRLENLLQRYPLRGIKGPVGTAQDMLDLLGGDAAKLADLEQRIAAHLGFSQAFTSVGQVYPRSLDYDVVTALVQLAAAPSSIAKTIRLMAGHELVTEGFKPGQVGSSAMPHKMNTRSCERVNGLMVILRGYASMTGELAGDQWNEGDVSCSVVRRVALPDAFFAFDGLLETFLTVLDEFGAFPAVVARELDRYLPFLATTKVLMGAVRAGVGREAAHEVIKEHAVASALAMREQGAERNELLDKLAADDRMPLDRAQLDALMADKLSFTGAAGDQVASVVSRIEAIAKEHPEAAGYAPGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7M2</accession>
    <name>A0A0F4J7M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="9" type="ORF">VR44_22125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="JZWV01000619">
        <property type="protein sequence ID" value="KJY29758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949314.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000619.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5157"/>
    <dbReference type="EnsemblBacteria" id="KJY29758">
        <property type="protein sequence ID" value="KJY29758"/>
        <property type="gene ID" value="VR44_22125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.308"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="8">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY29758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27524" checksum="E4B3005E7F55EFA1" modified="2015-06-24" version="1">MADDLFTLGDRTFTSRLIMGTGGAPSLDILERALIASGTELTTVAMRRLDPTVQGSVLSVLSRLGIDVLPNTAGCFTAGEAVLTARLAREALGTDWIKLEVVADERTLLPDGVELLDAAEVLVDEGFTVLPYTNDDPVLARKLEDVGCAAIMPLGSPIGSGLGIRNPHNFELIVERAGVPVILDAGAGTASDAALAMELGCAAVMLASAVTRAQEPALMAAAMRDAVSAGRLAHRAGRIPPRRFAEPSSPMDGRAALDPERPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N9</accession>
    <name>A0A0F4J7N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_21980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene886"/>
    <dbReference type="EnsemblBacteria" id="KJY29809">
        <property type="protein sequence ID" value="KJY29809"/>
        <property type="gene ID" value="VR44_21980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.276"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="349" mass="37226" checksum="F4A85B6FE2F22179" modified="2015-06-24" version="1">MSGIRFDSVSVAYHGTTVLDSLDLTVEPGEVMALLGPSGSGKTTALRAVAGFVRPVSGRVLIGGRDVTALPPHKRGIGMVVQQYALFPHLRVEDNVAFGLRAQKAPRAGIPARVTEALEMTGMAAYARRYPRELSGGQQQRVAIARALAIRPGVLLLDEPLSALDAQLRSGMLAELARLHRELPDVSILYVTHDQVEALTLADRIAVMDRARLQDCGTPQQLYRAPRTEFTASFVGNANLLPVTVADAGAVFAGRPLDLDTGRAAPGATATLCVRPHLLGLGEGPNALRGTITEVQWRGSTHRLYVDVGGHRVKADLPELRETPALGDEVTLHFEPRDAVLLAAGVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9N9</accession>
    <name>A0A0F4J9N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_22245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949335.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene485"/>
    <dbReference type="EnsemblBacteria" id="KJY29696">
        <property type="protein sequence ID" value="KJY29696"/>
        <property type="gene ID" value="VR44_22245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.335"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="505" mass="53918" checksum="BAE6896B03E41B0B" modified="2015-06-24" version="1">MASSLTKDAATPAPEKTFFGHPRGLATLFMTEMWERFSYYGMRALLVYYLVSGGADAATGSQGGGLAMTAATTTAIYSVYVSMVYLMAMPGGWFGDRVWGARKTVAIAGFVIMAGHLSLALPGQAMFFVGLILVAAGSGLLKANISTMVGHLYDGPDDPRRDGGFTLFYIGINLGAFVAPFVVGTVGKEHNWHLGFALAAVGMALGLTQFLIGTKHLSPKSSQVPNPLTPEERKAVLTKVALAVLGIAVFYGAVVALGAYTLNWALVPLTLAGLVIPVAVLARIKRDKELSGAEQSKMTAYIWFFIAAAVFWMIYDQGGSTLSLFADDKTADTVFGFGFSATWYQSLNPLFVMALAPVFAWLWLWLARKNQEPNTIVKFAMGLVLIGASFFVFIVPMGMATGDTKVSPMWLVSIYMIQTIGELCVSPVGLSVTTKMAPQKYASQMMGVWFLAVTAGDCTTSLLSIGGVDLNGTWVIGFQAAAAALAGFAVYAYRKKVQALMGDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Y5</accession>
    <name>A0A0F4J9Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000556">
        <property type="protein sequence ID" value="KJY30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948951.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000556.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30553">
        <property type="protein sequence ID" value="KJY30553"/>
        <property type="gene ID" value="VR44_20180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8741"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045924">
        <property type="entry name" value="DUF6343"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19870">
        <property type="entry name" value="DUF6343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9287" checksum="DCD15E1E82B908EC" modified="2015-06-24" version="1">MRTGNEPLTARSPLRLRFWLSLWGLVWAAGGAAVFSLAERPGWAAACAAVVVLAAVDLGVVVHHIHQGPHYQPGPDIPPYEPPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA64</accession>
    <name>A0A0F4JA64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">VR44_19775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000546">
        <property type="protein sequence ID" value="KJY30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948875.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000546.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30694">
        <property type="protein sequence ID" value="KJY30694"/>
        <property type="gene ID" value="VR44_19775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8574"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="318"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="436"/>
            <end position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="448"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="694" mass="74536" checksum="904FC452553DB993" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA90</accession>
    <name>A0A0F4JA90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease DDE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948860.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000544.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30719">
        <property type="protein sequence ID" value="KJY30719"/>
        <property type="gene ID" value="VR44_19695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8555"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="175"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="41459" checksum="23E0D24F1107695A" modified="2015-06-24" version="1">MSRPGPKIPPLSVTDAQRAVLEGWLRRRTTAQALAQRSRIVLECAEGHSVMEVSRRLRIAPDTVRTWRRRFIERGLDGLCDDPRPGVPRKITDADVERVIVKTLEETPKNATHWSTRSMAAATGMSQSSISRIWRAFALAPHRSQTFKLSTDPLFIDKVRDVVGLYLDPPEKALVLCVDEKSQIQALDRSQPVLPMVPGVPERRSHDYVRAGTTTLFAALEVATGKVIGSLHRRHRAAEFKKFLAKLDKEVPADLQVHLILDNYATHKTPDIKRWLLAHPRFHLHFTPTSASWLNLVERWFAELTQKKLKRGVHRSVRALERDIRAWLADWNENPRPFIWTKTADEILDKVAAYCRRISDSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAB8</accession>
    <name>A0A0F4JAB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000546">
        <property type="protein sequence ID" value="KJY30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3124"/>
    <dbReference type="EnsemblBacteria" id="KJY30693">
        <property type="protein sequence ID" value="KJY30693"/>
        <property type="gene ID" value="VR44_19770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8573"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="1">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20050" checksum="DCFE11EA027EAAB6" modified="2015-06-24" version="1" fragment="single">TIGGEAKLDDTALLELATEIEGHPDNVAACLLGGFTLAWMEGGSARAIRMDPADSIVPVVFVPSKPVLTETARGLLPRSVPHVDAAVNAGRAGLLVEAMTRRPEFLLPATEDRLHQEYRAPAMPESVALVNRLRADGIPAVISGAGPTVLALVDNDAADKVAQLAGEGWAANRLALDAAGASVLPLGAQGGQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAP7</accession>
    <name>A0A0F4JAP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000504">
        <property type="protein sequence ID" value="KJY31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000504.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7343"/>
    <dbReference type="EnsemblBacteria" id="KJY31275">
        <property type="protein sequence ID" value="KJY31275"/>
        <property type="gene ID" value="VR44_18480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8291"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22261" checksum="B6B2EE2F869D2C57" modified="2015-06-24" version="1">MGTLTGPESGTAATPARGLPKQARSRVTRRHLLEAAVSCLAEHGWAGSTVAVVAERAGVSRGAAQHHFPTREALFTAAVEYVSEERSTALRELFQAAPAPRPAVVEALVDLYTGALFRAALQLWVAASNEEQLRPQVTELEARVGRETHRIAVELLGADESVPGVRETVQGLLDMARGLGLANVLTDDTARRERVVAQWSRIIDAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAT8</accession>
    <name>A0A0F4JAT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266087.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5503"/>
    <dbReference type="EnsemblBacteria" id="KJY30081">
        <property type="protein sequence ID" value="KJY30081"/>
        <property type="gene ID" value="VR44_21235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8971"/>
    <dbReference type="eggNOG" id="COG3703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="16305" checksum="F55DABF838DA7E99" modified="2015-06-24" version="1">MSLYAAYAGNLDPRLMTRRAPHSPLRGTGWINDWRLTFGGEQMGWEGALATIVEAPRQQVFVALYDIAPLDEDSMDRWEGVGLDIYRRMRIRVHTLDGEEAAWCYVLNGYEGGLPSARYLGEIADAAESAGAPHDYVMELRKRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAV0</accession>
    <name>A0A0F4JAV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000500">
        <property type="protein sequence ID" value="KJY31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948624.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31335">
        <property type="protein sequence ID" value="KJY31335"/>
        <property type="gene ID" value="VR44_18415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8233"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="28589" checksum="309532136D808C19" modified="2015-06-24" version="1">MLSEGALRAHLLAARLAGPVATTREESLRSYRLFAARDPRVLLGLDPQGRWDVGALLGLMADRCGVSADPAQVSGPDVIDPERTVAALGVFAERLREAAGARSPVLFGTGHPHRLLGFYAGLAGAMSAAGCVVLTPAQGVHVDMTTRFGVRTHRIDYVRGVALVREPGARAAASATGAHTHSPLPVRVALGALAESGGPLPELVVGDHGWVCGAGQLGVEAIGLADTDDPALFVGEAEGRVAAVVPLDDAVFSAAYGPLARFVLQRAGLPVRQEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBD8</accession>
    <name>A0A0F4JBD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000489">
        <property type="protein sequence ID" value="KJY31500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948544.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000489.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31500">
        <property type="protein sequence ID" value="KJY31500"/>
        <property type="gene ID" value="VR44_18015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8149"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13649" checksum="45F76BC64B112E02" modified="2015-06-24" version="1">MTSLIRHITIDCHDAYALGEFWAEVLNGSLHEDDSPGDDEVLLTTEGGALLFIQVPDTKSVKNRVHLDLQPQDRTRDEEVERLVALGAKLVGDHRRPDGTGWATLADPEGNEFCVERSAAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBW4</accession>
    <name>A0A0F4JBW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_20485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949005.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000563.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6653"/>
    <dbReference type="EnsemblBacteria" id="KJY30446">
        <property type="protein sequence ID" value="KJY30446"/>
        <property type="gene ID" value="VR44_20485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8808"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="640"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="832" mass="89635" checksum="02274A47213A389D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC67</accession>
    <name>A0A0F4JC67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948942.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000555.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30561">
        <property type="protein sequence ID" value="KJY30561"/>
        <property type="gene ID" value="VR44_20150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8735"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="12698" checksum="F4E707E5F5EB7482" modified="2015-06-24" version="1">MGGRQATTERRPGTRVPAGLSGREVVIPPGGCTGWHYHLVPLMAVVTAGTLTRILDDGTVEVHPAGATFVEPEGHDHVHLGRNLGAAPVVLHITCALADDDPWAVPAPAPLAATPCGCPDHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCC3</accession>
    <name>A0A0F4JCC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948570.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31408">
        <property type="protein sequence ID" value="KJY31408"/>
        <property type="gene ID" value="VR44_18155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8178"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="90"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="26717" checksum="CD76877D0D6316D6" modified="2015-06-24" version="1">MNGPGIELTLAPELRLFAPPSRRVDRVPTATDGASSLGHVVESAGVPLTEVGRLLVDGREVPVSYVPQAGQSVEVFGVDRPQQVPGAPLRFLLDVHLGTLARRLRLLGVDAAYDNEDPGDPALATRSAAENRVLLSRDRGLLRRREIFAGAYVYSDNPDDQLRDVLGRFAPALAPWTRCTACNGPLHEADKDSVGDRLEHGTQRSYDVFAQCSDCERVYWRGAHHSRLERIVDEALAEFGDGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCJ9</accession>
    <name>A0A0F4JCJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VR44_17125</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948376.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3063"/>
    <dbReference type="EnsemblBacteria" id="KJY31920">
        <property type="protein sequence ID" value="KJY31920"/>
        <property type="gene ID" value="VR44_17125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7957"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="51278" checksum="15A6E5B5B3E20F64" modified="2015-06-24" version="1">MRRSKIVCTLGPAVDSLEQLKALIEAGMNVARFNFSHGSQAEHQERYDRVRRACEETGRAVGVLADLQGPKIRLETFAEGPVELVRGDEFTITTEDVPGDKSICGTTYKGLPGDVAKGDQVLINDGNVELRVTEVEGPRVKTIVIEGGVISDHKGINLPGAAVNVPALSEKDVDDLRFALRMGCDMVALSFVRDANDVKDVHRVMDEEGRRVPVIAKVEKPQAVENMEAVVAAFDAVMVARGDLAVEYPLEKVPMVQKRLIEMCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILDGADAVMLSAESSVGAYPIETVKTMSKIVAAAEEELLSKGLQPLVPGKKPRTQGGSVARAACEIADFLDGKALVAFTQSGDTARRLSRYRAQQPILAFTTDVNTRNQLTLSWGVESAIVPHADSTDAMVELVDAEVLKLQRFNTGDTMIITAGSPPGVPGTTNMVRVHHLGGTGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCV0</accession>
    <name>A0A0F4JCV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000433">
        <property type="protein sequence ID" value="KJY32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948247.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000433.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32182">
        <property type="protein sequence ID" value="KJY32182"/>
        <property type="gene ID" value="VR44_16435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7684"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="593" mass="62087" checksum="9927BAF0FE320CE5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDD9</accession>
    <name>A0A0F4JDD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948410.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31829">
        <property type="protein sequence ID" value="KJY31829"/>
        <property type="gene ID" value="VR44_17295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7994"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="41113" checksum="3152C57FF3E69E49" modified="2015-06-24" version="1">MPVAVYVLGLSVFALGTSEFMLSGLLPPIAEDMHVSIPRAGLLISAFAIGMVIGAPLLAVATLRLPRRTTLIALISLFGLGQVAGALAPSYGLLFASRVVSALACAGFWAVGAAVAIAMVRTDQRARAMSVMIGGLSIANVLGVPAGAFLGEQFGWRSAFWSVGAASAIALAGILALIPKIPLPAEKPRLRRELGIYGDRQVWLAVAVTALAAGGVFCAFSYLSPLLTETAGLGSAWVPWVLALFGVGALVGTTVGGRIADGRLFGVMIWGITASTAFLTALALLASVQVAAVGLSFLLGVSAFFTAPALNARMFNVAGAAPTLAGATTTAAFNLGNTGGPWLGGTVIDAGYGYAATAWAGAAMTVTAIALTLLALRIDRRSGATRLITGSTATPSPTEAQPTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEN5</accession>
    <name>A0A0F4JEN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32660">
        <property type="protein sequence ID" value="KJY32660"/>
        <property type="gene ID" value="VR44_15510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7502"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="15086" checksum="EE2B05BBAFE1BA69" modified="2015-06-24" version="1">MHIDAPLDAVGLDPRGVMREPDFAEPQNAAWYQDGPTPGEPGAAAIVGHMDTPQAPQAVFFHLKDLAKGGEIDVHRTDGTTAVFTVDAVDTFKKDDFPTSKVYGDTGGRAELRLITCGGDLTADRHWDSNVVVFAHLTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFQ6</accession>
    <name>A0A0F4JFQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein VR44_14380</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_14380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947871.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3328"/>
    <dbReference type="EnsemblBacteria" id="KJY33172">
        <property type="protein sequence ID" value="KJY33172"/>
        <property type="gene ID" value="VR44_14380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7225"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26844" checksum="68269CFB9DBFBE7B" modified="2015-06-24" version="1">MSGHSKWATTKHKKAVIDAKRGKLFAKLIKNIEVAARMGGPDIDGNPTLFDAVQKAKKQSVPNKNIDSAVKRGGGLEAGGADYETIMYEGYGPNGVAVLIECLTDNRNRAASDVRVAMTRNGGSMADPGSVSYLFNRKGVILLPKGELSEDDVLGAVLEAGAEEVNDNGETWEIISEATDLVAVRTALQEAGIDYDSADSSFVPTMQVELDEEGARKIFKLIDALEDSDDVQNVFANFDVSDEVMEKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG43</accession>
    <name>A0A0F4JG43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000396">
        <property type="protein sequence ID" value="KJY32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948034.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000396.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32728">
        <property type="protein sequence ID" value="KJY32728"/>
        <property type="gene ID" value="VR44_15315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7465"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7805" checksum="B4E2141A8D35414B" modified="2015-06-24" version="1">MRATEGDQLVQHGRIVGQHDRVGEIVEVLGENGAPPYRVHFPDGHDAVMSPGPDCVVRHPDRPEGTSTTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG64</accession>
    <name>A0A0F4JG64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000453">
        <property type="protein sequence ID" value="KJY31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948371.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3071"/>
    <dbReference type="EnsemblBacteria" id="KJY31941">
        <property type="protein sequence ID" value="KJY31941"/>
        <property type="gene ID" value="VR44_17085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7949"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18503" checksum="AE99D655225F0AE8" modified="2015-06-24" version="1">MPKPLSLPFDPIARADELWRQRWGPVPSMAAITSIMRAHQILLGEVDAVVKPYGLTFARYEALVLLTFSQAGELPMSKIGERLMVHPTSVTNTVDRLVRSGLVAKRPNPQDGRGTLASITEKGREVVEAATKDLMAVDFGLGPYDAEECAEIFALLRPLRVAAGDFEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJB8</accession>
    <name>A0A0F4JJB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+)--protein-arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_12160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000299">
        <property type="protein sequence ID" value="KJY34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947465.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000299.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34295">
        <property type="protein sequence ID" value="KJY34295"/>
        <property type="gene ID" value="VR44_12160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6412"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006471">
        <property type="term" value="P:protein ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="551" mass="59708" checksum="7DFB8F0075C36388" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK39</accession>
    <name>A0A0F4JK39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000309">
        <property type="protein sequence ID" value="KJY34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947511.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000309.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34184">
        <property type="protein sequence ID" value="KJY34184"/>
        <property type="gene ID" value="VR44_12410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6474"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470594" description="SLT domain-containing protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="61"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11966" checksum="D11A72A3D7FD9176" modified="2015-06-24" version="1" fragment="single">MSNAVIRRIAASKKTFAGTVLALGVAGSMLATVPAQAAPTSAKAIAQQMIKDPAQFAAFDKIVTHESGWDYTATNSSSGAYGLVQALPASKMSSAGADWKTNPATQIKWGLDYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM51</accession>
    <name>A0A0F4JM51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000319">
        <property type="protein sequence ID" value="KJY34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947580.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000319.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34011">
        <property type="protein sequence ID" value="KJY34011"/>
        <property type="gene ID" value="VR44_12790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6639"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="30104" checksum="93046EAF3385D94C" modified="2015-06-24" version="1">MRSSNPVFSRRGFSRDNGGYAGFDAQYAQAGTATNPYATNPYAIDPTTGMPAAPARGAAMTIDDVVSRTAMTLGVLIVTSVVAWLALPVDPANLGKSYMIGVGAALVAFVLAMVQSFKRKPSPGLILAYAAFEGFFLGVISAATSYYLSAGVVIQAVLGTMCVFAAVLVAYKMRWIRVTRRFTGFVMAAALGFVLLMLANSLFMLFGGGDGLGFRSGPLGIVFGIVGVVLGACFLAMDFKQVEDGVTYGAPREEAWLAAFGLTMTLVWIYLELLRLFQILSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM98</accession>
    <name>A0A0F4JM98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000230">
        <property type="protein sequence ID" value="KJY35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35335">
        <property type="protein sequence ID" value="KJY35335"/>
        <property type="gene ID" value="VR44_10405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5955"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046187">
        <property type="entry name" value="DUF6215"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19721">
        <property type="entry name" value="DUF6215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="21921" checksum="3735C5553FE2B773" modified="2015-06-24" version="1">MGEDIDAANRGGRAWGQAVAALVLVPGLALGLWWWGRAKGTTTGGSRPVVRTRTARRRRGMCPAGNCASLYRPGLDALLGIPGREVQTVSGGSRTSRPGGTGEAIVTPTARVEFEGYAVTLDAGYGGLLDDAALLRVAEKVLPAVPGAPPADATAGGRPVPDEQRSQESVLRAARTGPRAAAVRLSRGPAQGLRSRVPSVRREPPGPRGPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMK9</accession>
    <name>A0A0F4JMK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947245.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34988">
        <property type="protein sequence ID" value="KJY34988"/>
        <property type="gene ID" value="VR44_11005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6085"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10226" checksum="A37EF96EEC2D8C93" modified="2015-06-24" version="1">MAGYVEQKEDVIRRLRRIEGQVRGVQRMVAEDVYCIDVLTQVSAIKAALQSCAVTLLDEHLNCCVTEAIAQGGDRARVKVGEASRAIARLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMM5</accession>
    <name>A0A0F4JMM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947028.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35617">
        <property type="protein sequence ID" value="KJY35617"/>
        <property type="gene ID" value="VR44_09800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5460"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22677" checksum="8460F1DADBF42EB4" modified="2015-06-24" version="1">MKLTKRLHSCVQLEKDGHTLVIDPGVFSEPDAGLGADVLLVTHEHPDHFDEGRLRAALDANPAAALWTLRSVAERMAPAYPGRVHTVGHGDTFTAAGFEVQVHGELHAVVHPDIPRVTNVGYLVEGSLFHPGDALTVPDAPVDTLLLPVHAPWNKIAEVVDYVREVKPRRAVDIHDAYLADIARPIYDFTLDKLGGAPHSRLGAGESAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP76</accession>
    <name>A0A0F4JP76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_11460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947332.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34741">
        <property type="protein sequence ID" value="KJY34741"/>
        <property type="gene ID" value="VR44_11460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6190"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="36617" checksum="9F780B9344781A1A" modified="2015-06-24" version="1">MPVDLRHRPFLKELDLTPEEFRHLLELSEQLKAARSAGTGSRRLHGKNIAVIFEKTSTRTRCAFEVAAHQEGAHVTYLEPASSQLGHKESIKDTARVLGRYYDGIEYRGSDQRLVEELARYAGVPVWNGLTDQWHPTQSLADVLTMWEHTDKPLEQVSFAYLGDARNNVGSSLLITAAMLGMDVRMVAPAALANAPEVVAAARAAAASTGARITLTEDVAEGVAGVDFVYTDVWLSMGEPAEMWDERIALLRPYQVTMDVLKATGNPQVKFMHCLPAFHDSDTTVGAKIAARTGMTAMEVTDEVFESVHSIVFDQAENRLHTIKAVLVATLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPV2</accession>
    <name>A0A0F4JPV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946907.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35783">
        <property type="protein sequence ID" value="KJY35783"/>
        <property type="gene ID" value="VR44_09175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5099"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="48257" checksum="111D03033B52B702" modified="2015-06-24" version="1">MTSEQPDTSRATRRRPAWAIGSIAAAVLLAGGGTAYWASTAYGDAPRGGGRTGDTAAVAPRDAGTPSRPGIAPGEPDPHGAGVTYRADGPLPQGPASAPSFSSSGEVGSEEVARLAQALGISGAPRLSGEQWLAGESADGSGPRLSVTRKAPGTWSFSRFQAGPGDDCVRGKDTCGPATLPEGGSAQSSAQGSAPGSGAGTPVSEQAAKAAAAPVLAAAGQGDAKVDARLVTGSVRVVVADPVVGGLPTQGWSSRITVGADGAVVAGSGELKAPVRAAEQPVIGAAEALDRLNAASKGGNGTGPGPSGCATSVPLTPDTPTGATDTLPCNPEPRPVKPPRTESVKGAVLGLTAGTVDGVRGLVPAWLFEVGGTDGKPGRTVVQPAAAREDSPAPVPPQGRTVPGFSYGQADRTLTVNFWGGVCSTYALEAREEAGSVLVKITDTPNQPGQACVMLAKEMSVTAQLKQPLGDRKVVDATTGKALPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQA4</accession>
    <name>A0A0F4JQA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_08140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000164">
        <property type="protein sequence ID" value="KJY36390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946717.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000164.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36390">
        <property type="protein sequence ID" value="KJY36390"/>
        <property type="gene ID" value="VR44_08140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4377"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="29761" checksum="DAB1ABF2FB797008" modified="2015-06-24" version="1">MTAVPIRRPGLARIRAAGSPLHLACLAFVALVTLAALLAPWLIPHDPNTVDLADALAAPSAAHPLGVDAAGRDTLSRLLLGARTSLLGPLGVVAFSTVAGIAIGTAAAWRGGRLDSVLSRSTELVFAFPGMLLAILVVSVHGEGLLAPVLALAVAYTPYVSRLTRSLVLAERARPYVSAHRVQGHSALQICRRHVLPNIAPVVLAQSAINFGYALMDLAGLSFLGLGVPALTPDWGRMVFDGQTAIQHGYPLSAILPCAVVVLTVVAFNVVGERWADRVARRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQE8</accession>
    <name>A0A0F4JQE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947198.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35161">
        <property type="protein sequence ID" value="KJY35161"/>
        <property type="gene ID" value="VR44_10675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5882"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471145" evidence="1">
        <location>
            <begin position="35"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="30346" checksum="FBD23B0D129B3F5D" modified="2015-06-24" version="1">MVLSRGARWAAGVTAAVCMALLLGPSAPGGAAPAAGPLRFGAAGEVVPDRVATWNLCNPCGGIGHDFGRAKEIARYAPQVIGLQEACVRDVEQIRTYLEEVYGLVYRVEYGTVLRNWNRCGGPPWRPGGFGQAILSAALMSDRVNVEYPDGGSEDRGYLAVTTLVGGRPVRVFNTHLAERRQGGVRAGQVEARHDRAIVLGDFNAVPYAPELGPMWALALDTDPGCRPATAGTGAGDVCTVTTDWNSKFDYVFLRGITPRTHRVRPSPYSDHHLLYSDLNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS62</accession>
    <name>A0A0F4JS62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946384.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37207">
        <property type="protein sequence ID" value="KJY37207"/>
        <property type="gene ID" value="VR44_06275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3009"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="12015" checksum="0938150D4DA5C85E" modified="2015-06-24" version="1">MQRTKRNGAEVFRITGARMGLAEDVRGRQRRYVISMGIRTLSVVATVILWNVERHVAIVTLAAGLLLPYIAVVIANAGRESTPSLPSHFVPAPVRPALEPGNLRKTSDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS77</accession>
    <name>A0A0F4JS77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37222">
        <property type="protein sequence ID" value="KJY37222"/>
        <property type="gene ID" value="VR44_06250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3004"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="19642" checksum="7009ADC2E5CB9F9B" modified="2015-06-24" version="1" fragment="single">MPTETGGHPSPDRDMIEQTVPDPGRTPVAHSIDAAFTALPLRALADAALARARALGADHADFRLERIRSASWRLRDAKPSGGSDTTDLGYAVRVVHGGSWGFASGVDLTMDGAAKVASQAVAMAKLSAQVIKAAGSDERVELADEPVHADKTWISAYDVNPFEVPDAEKSALLADWSSRLLAAEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT44</accession>
    <name>A0A0F4JT44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_06890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000128">
        <property type="protein sequence ID" value="KJY36918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946486.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000128.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2768"/>
    <dbReference type="EnsemblBacteria" id="KJY36918">
        <property type="protein sequence ID" value="KJY36918"/>
        <property type="gene ID" value="VR44_06890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3462"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117002" description="Glucanase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="10">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY36918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="577" mass="60250" checksum="A4C1F33F2F08F2CA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU16</accession>
    <name>A0A0F4JU16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946690.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36446">
        <property type="protein sequence ID" value="KJY36446"/>
        <property type="gene ID" value="VR44_08020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4430"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="538"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="643" mass="69185" checksum="ED45AD84C681B7B0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUB4</accession>
    <name>A0A0F4JUB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37358">
        <property type="protein sequence ID" value="KJY37358"/>
        <property type="gene ID" value="VR44_05865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1989"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="99"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="29285" checksum="187986F7A92CF634" modified="2015-06-24" version="1">MPPTARLLSCRVLDTVHQPIRQAKFEVTDPIGRRVVSGETDPYGGFTAAMPEGEYRLSVSAEGYAPFHGATLVGDPAQPGTAEIVLDSVEPPVLPQPGHWELDPTHSSIGFTAKHIGFARIHGRFTTFAGAVRIAERMEDSSMHVIIDAASIDTGLRMRDDHLRSADFLDAARYPTVEFYSERFIHRSGSRWAVAGALTLHGVSRSVTLDTQYLGVGTGLEGEPRAACRATAELHREDFTLNWQSMLAQGIAAIGSSVEVALDVQIVHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVF2</accession>
    <name>A0A0F4JVF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000128">
        <property type="protein sequence ID" value="KJY36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946489.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000128.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2772"/>
    <dbReference type="EnsemblBacteria" id="KJY36921">
        <property type="protein sequence ID" value="KJY36921"/>
        <property type="gene ID" value="VR44_06910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3466"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="31582" checksum="B20861418885F09D" modified="2015-06-24" version="1">MARTPGTTASGPPRVRRLRPSAGRQRHAGPLAYVLLGLAALLSLFPLYWNLVAASHTGERVVKAPAPLLPGPRLLDNLSFAWNQVDMGEALVNTTVVAGLVALSTVLFSTLAGFAFARLPFKGRSALLALVVATMTIPPQLSVIPLYEIITDLGWVDQLQSVVLPSLVAAFGVFFMRQYLIEALPVELVEAARVDGAHSLRIIWHVVFPVARPAMAVLGMLVFVQAWNDFFWPFIALTPDGNPTLQVALAGLGAGNHTVDQAVVLTGALISTLPLLLVFAVLGRHIVGGITAGAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWJ3</accession>
    <name>A0A0F4JWJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945771.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4911"/>
    <dbReference type="EnsemblBacteria" id="KJY38742">
        <property type="protein sequence ID" value="KJY38742"/>
        <property type="gene ID" value="VR44_03020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7336"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16947" checksum="A0206AEAC3600CD2" modified="2015-06-24" version="1">MAIEVGTKAPDFELKDNHGATVRLSDFRGEKAVVLLFYPFAFTGVCTGELCELRDQLPRFQNDDVQLLAVSNDSVPTLRVFADQEGLEYPLLSDFWPHGETSRAYGVFDEEKGCAVRGTFVIDKDGVVRWSVVNGLPDARDLNEYIKALDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXC8</accession>
    <name>A0A0F4JXC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000067">
        <property type="protein sequence ID" value="KJY38413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945900.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38413">
        <property type="protein sequence ID" value="KJY38413"/>
        <property type="gene ID" value="VR44_03700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8278"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21202" checksum="EAADAD665228A543" modified="2015-06-24" version="1">MVTGQRGRPRSFDRDAALDKAMLTFWEHGYEATSISDLTRTLGIGAPSLYAAFGDKRKLFDEVVVVYGSRYGDFAAVALREEPTAGAAIGRILREAAEIYTDPAHPPGCMVISAAANTTSQEVAEALRERRNANLALFESRIRADVASGVLPADTDARALARYAGAVLQGMSQQSRDGATREELEAVAERALLAWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY20</accession>
    <name>A0A0F4JY20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945645.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2420"/>
    <dbReference type="EnsemblBacteria" id="KJY39020">
        <property type="protein sequence ID" value="KJY39020"/>
        <property type="gene ID" value="VR44_02310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6752"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13906" checksum="66360982BAC8EBC9" modified="2015-06-24" version="1">MESYTIGQAARLLGVSVDTARRWADAERFPTRREGTRRMVDGPDLAAFCVEAAQEAADGVEAPHTSARNAFPGIVTGVRLGTVDAQVEIQAGPHRIVSLLTREAVEELGLEVGSRATARVKSTSVFVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYV0</accession>
    <name>A0A0F4JYV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945455.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4686"/>
    <dbReference type="EnsemblBacteria" id="KJY39547">
        <property type="protein sequence ID" value="KJY39547"/>
        <property type="gene ID" value="VR44_01295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2976"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="32889" checksum="C6194421835C1445" modified="2015-06-24" version="1">MFDSRHIRTFHEVVASGSYSAAARVLGYTQPAITQQMKALERAVGTPLFTRVGRKMKLTEAGESLARHAESILGSLSAAEAQLKAYTRLRTGRVRVCGFPSANVTLVPEALSGLAKDHPGVQVELLEGEPPESLRRLQRGECDITLAFTYPGLHEEVPEEVTEVRLLEDQLTVLLPTGHPLARRRAVHLADLAEEQWIAGCPRCRANLLHECAELGFVPDIRFATDDNLVVQSLVAQGLGVAMMPALVLPSLSLSRVCGRVLEPAARRHIAAYVYRDHLRIPATAVVLDELKRAASNRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ05</accession>
    <name>A0A0F4JZ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945950.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38246">
        <property type="protein sequence ID" value="KJY38246"/>
        <property type="gene ID" value="VR44_04015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8708"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="238"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="544" mass="56200" checksum="839784A7B0F7C567" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZJ8</accession>
    <name>A0A0F4JZJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39143">
        <property type="protein sequence ID" value="KJY39143"/>
        <property type="gene ID" value="VR44_02155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5694"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="39319" checksum="70073788E416F618" modified="2015-06-24" version="1">MRFHARSPIEPAWISQVLVPVVRSLRIEHNATVAYLARGWKHGPHVELIARGPDGIPWQDIAGSIDWRLEDLPEPMTGEQYLAQARELGRLERVEPPYLPLHPRGTVEFFDRNPGITWPAGLEAPRDLVLTRMFTPLARLMDLAAGRDAGVPVTALAEAFTALCTAHPGGPSYGVFSLRSHAEAFLYWASSVKDPRPSFARRLEADAPMLRAVVERARDGAESSEAAEFRAAFAYGMGVLDTAAARGDLSAELLDGLAPVEDRASTAPPGHRGPVAEGRSEFHSTIAESRAVDRTPSWFASYRLLINLFYSRLPLLGVTPIQRYYLCFAIAETVDEVYGEDWRERLRRAAERKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0K2</accession>
    <name>A0A0F4K0K2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945424.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4723"/>
    <dbReference type="EnsemblBacteria" id="KJY39644">
        <property type="protein sequence ID" value="KJY39644"/>
        <property type="gene ID" value="VR44_01105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2934"/>
    <dbReference type="eggNOG" id="COG2164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12907" checksum="89DA8062C4A0C63E" modified="2015-06-24" version="1">MQIRISWPAGLLTATLDETPTSKALAAALPISASANTWGEEVYFDTGVSVDLEHDARQVVEPGTVAFWTEGDALALPYGPTPISRGGESRLASPCNVLGSFDGDPRLLATVRDGDPIRVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K343</accession>
    <name>A0A0F4K343_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_01125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945425.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39576">
        <property type="protein sequence ID" value="KJY39576"/>
        <property type="gene ID" value="VR44_01125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2939"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="212"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="246"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="47559" checksum="27D7A07031C5C48D" modified="2015-06-24" version="1" fragment="single">ALQDYWLRWLLPVGTAVLVGTGSVVFTAWLLPGAGLVLAVGLLLAGVGVPLVSGACARSAERRLAPARGELATRVADLLTGTAELTVAGALADRKARARDADGVLTRIASRGAAAAGLGGGLSALVCGVTVVGAAFAGAGAVADGRLSGVAMAVVVLTPLAAFEAVAGLPLAVQYRQRVRRSAERVYEVIDAPVPVAEPAEPQEPPVSPFPLRLTGLAARHDGQERDALHGLDLTLEAGRRIAVIGPSGSGKTTLAQVLLRFLDPRHGAYTLGGTDARALDGDGVRRLVGLCAQDAHIFDSSVRENLRLARTGASEEQLREALAAARLLHWADGLPDGLDTLVGEHGQRLSGGQRQRLALARALLADFPVLVLDEPAEHLDLATADALTADLLAATEGRATVLITHRLAGLEAVDEVLVLDRGAVVQRGAYAELAAVEGPLRNLLERERRAGAIPADSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3I0</accession>
    <name>A0A0F4K3I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_00600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4822"/>
    <dbReference type="EnsemblBacteria" id="KJY39741">
        <property type="protein sequence ID" value="KJY39741"/>
        <property type="gene ID" value="VR44_00600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2826"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="18700" checksum="77EC235F5E1B959A" modified="2015-06-24" version="1">MPAPPVPPAPAAAPRPLDPIDRSIMRLLQTDGRASIRSVAEQVHVSRANAYARINRLIDDGVIRGFTARVNHERAGQGASAYITLKIVQNSWRTVREKLRELPGAAHIALVSGDFDVLLLVHTADNRTLRELVLTRLQSIPEVLSTRTLLVFEETDLLDPGPPAGGPALAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3I6</accession>
    <name>A0A0F4K3I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945334.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39746">
        <property type="protein sequence ID" value="KJY39746"/>
        <property type="gene ID" value="VR44_00565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2819"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="40093" checksum="5281939DC83FAC2F" modified="2015-06-24" version="1">MFHVKLHGQDAMARGADEKLVARRVKLPKRVVGRPLRQVTKRLLMALFVLCLTVLIVWLDREGYHDNADDKVGFVDSVYYATVTLSTTGYGDIVPYSDSARLVNILLITPLRVLFLIILVGTTLEVLTERTREEWRLNRWRKNLREHTVVVGFGTKGRSALQTLLATGLPKEQVVIVDPSAKVIDMANAEGFTGVVGDATRSDVLLRAELPKARQVIIATQRDDTAVLVTLTARQLNRGAKIVTAVREEENAPLLKQSGADAVITSASAAGRLLGLSVLSPRAGAVMEDLIHQGSGLDLIERPVNRSEVGRGVRETEDLVVSVVRGHRLLPYDDPHASPLQLTDRLITIVRATPPTTPQVTLGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K463</accession>
    <name>A0A0F4K463_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_00425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945295.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1053"/>
    <dbReference type="EnsemblBacteria" id="KJY39961">
        <property type="protein sequence ID" value="KJY39961"/>
        <property type="gene ID" value="VR44_00425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.83"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="317"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="539" mass="60098" checksum="85DDF99F376FEE41" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9R8</accession>
    <name>A0A0F4I9R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001616">
        <property type="protein sequence ID" value="KJY18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952549.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001616.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18203">
        <property type="protein sequence ID" value="KJY18203"/>
        <property type="gene ID" value="VR44_39640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6045"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="28074" checksum="75DECDE40DDAA8ED" modified="2015-06-24" version="1">MGAAVGEGRAVPRYLQIAEDIVQQVRTGVLQPGDQVPSEAEMVDRYGVSGGTVRKAMLEIRASGLVETRHGKGSFVKARPPVRHRSSDRFRRSLRQGAKAAYLAESEQSGATAKVSVIHIGPVDAPEAIAQRLGVDVGAKVLARRRLYFRNGTPVETATSYLPWDVVRDIPELFAENSGDGGIYARLEEHGHVFREFVETLQARPAAKAEASELALSPGATVVHLLRNAVTTSGRVVEVCDTLMAADQFVFEFRIPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAK1</accession>
    <name>A0A0F4IAK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001595">
        <property type="protein sequence ID" value="KJY18694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952522.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001595.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18694">
        <property type="protein sequence ID" value="KJY18694"/>
        <property type="gene ID" value="VR44_39495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5988"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="20821" checksum="C1975875FF69F039" modified="2015-06-24" version="1" fragment="single">PAPARRAPAGAAVLREDVTEAIRAAVLAELAESGFARMSIEGIARRAGVGKTAVYRRWKSKLHLVLDLIGVFAVDGLPVPATGSLYGDVRALLEVMTHVLRHPVASAVIPDLLVESARNPEIADAVRGALLDGQRRLAEGIVAEAVARGELEDTASPERALDLAIGPLYWRQVVVGDAVPAGYLDQLARSVVAGLKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAV9</accession>
    <name>A0A0F4IAV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001645">
        <property type="protein sequence ID" value="KJY17801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952580.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17801">
        <property type="protein sequence ID" value="KJY17801"/>
        <property type="gene ID" value="VR44_39820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6146"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27594" checksum="86190DF27ECCFABC" modified="2015-06-24" version="1">MTGVRNFRDVGGLPTTDGRRVRPGRLFRSGHLAHATETDAEFLASLGLHTVFDFRNAADQALEGPDVALPGVRNVNIPLSDPADGGEFWRMVREGGLDQLRGLLGGGRAAARMAGSYRAMIRDRTAEHGRVVRALAEDSVPALLHCAAGKDRAGLAIAVTLLALGVDREAVVADYLESNAPHNRYRVRRDSEAPEAHSPEVMELLAPLFDARAEYLLAAYETIDGHWGGVDRYLAEGLGLTPVTLERLRERLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB87</accession>
    <name>A0A0F4IB87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001558">
        <property type="protein sequence ID" value="KJY19300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19300">
        <property type="protein sequence ID" value="KJY19300"/>
        <property type="gene ID" value="VR44_39170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY19300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="474" mass="48567" checksum="87DE391CD4ADA4E3" modified="2015-06-24" version="1" fragment="single">YWLETRPAAGDLASAGLGSAGHPLLGAAVALADGDGLVLTGRLSLSAQPWLAQHLVMGAALLPGTALVDLAIRAADEAGCDRVEELTLQAPLVLPAQGAVQIQVTVGGPDGNGHRSVSVHSRPDGTGSDTPWSAHAAGVLAPPAGAAPADELSQWPPADAEALPLDGYYERLAELGFGYGPLFQGLRSLWRRGDEVFAEVSLPQDTEAGGFGVHPALLDSALHAVGLGGLLPDTGRGRIPFAWNGVRLEATGATALRVRLTSPAPDTVSLTAADGTGRAVVTVGSLVLRTVTADQLPAAVGVDHPDALYRLDWPVLPLGDGDTPQDTTGPLTRVEDLTGLRALLDGLGDAGLPADTVLVPAPRGSRTTTEAEQVHTVTREGLALLRTWLGDDRTTDSRLVSRLVLLTRGAVAPEPGTTVTDPAQSALWGLVRSAQSENPGRLVLADLTPAPAPASAAADADADADADADAEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDM5</accession>
    <name>A0A0F4IDM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001587">
        <property type="protein sequence ID" value="KJY18766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18766">
        <property type="protein sequence ID" value="KJY18766"/>
        <property type="gene ID" value="VR44_39445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="18404" checksum="99511410D1A223EA" modified="2015-06-24" version="1" fragment="single">MPTAGGGGLPVFTPRRAPVLTADFTSTAQWVAGRSWAYPDGGPVNPGDNKLDHLVEDPSYSRSGTFRATRRPDGNWDTGLLTTEGSDQGFTVRTGDVLEARVRLPTETGAWPAIWTWRDGGQEIDVFEYHPDNPDLLELSNHVREAHRYHRDPAVRPGAWVDLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEN7</accession>
    <name>A0A0F4IEN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001500">
        <property type="protein sequence ID" value="KJY20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952364.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20485">
        <property type="protein sequence ID" value="KJY20485"/>
        <property type="gene ID" value="VR44_38665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5409"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20680" checksum="6680C7A840FE9469" modified="2015-06-24" version="1">MLPTHGGDDPARPAGLRIGHLDLAGRVDEALRVQAVAFGLSEEEVGIRRYIVQRHMTCRGARALGAFTDDGALAGFVYGMPNDRAHWWSTIVEPYLRATGTEHWLDDSFVITELHVHPGFQGRGVGRALITRITDTAEEPRSILSAIDTDSPARGLYGALGYQDLARRVHFPSASLPYAVMGAPLPLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INY3</accession>
    <name>A0A0F4INY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001373">
        <property type="protein sequence ID" value="KJY23745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23745">
        <property type="protein sequence ID" value="KJY23745"/>
        <property type="gene ID" value="VR44_37400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9793" checksum="BF59764BD3CD077E" modified="2015-06-24" version="1" fragment="single">MEENLQTGRKLRPVDLARAHGLSTQAVRNYEEAGVLPPAARGENGYRAYTPGHALALAAFLALVPGHGHATATAVMRAVNRGACDEAFRLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPB8</accession>
    <name>A0A0F4IPB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001391">
        <property type="protein sequence ID" value="KJY23494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952162.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001391.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5947"/>
    <dbReference type="EnsemblBacteria" id="KJY23494">
        <property type="protein sequence ID" value="KJY23494"/>
        <property type="gene ID" value="VR44_37600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5025"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="475"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="540" mass="57411" checksum="C5B746B203449D1A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPK8</accession>
    <name>A0A0F4IPK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001416">
        <property type="protein sequence ID" value="KJY22576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1420"/>
    <dbReference type="EnsemblBacteria" id="KJY22576">
        <property type="protein sequence ID" value="KJY22576"/>
        <property type="gene ID" value="VR44_37880"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="25776" checksum="B0A7ABC0C0FA460F" modified="2015-06-24" version="1" fragment="single">MTRQRSHSYRQPGVVLTDHHFTVPLDHARPDGEHIELYARETVATGKDPERLPWLLYLEGGPGFGARRFTGREAWLERALADYRVLLLDQRGTGRSTPANRQTLPLRGTPAQQADYLAHFRADSIVRDAESIRRTLTGGAPWTVLGQSFGGFCTTHYLSTAPEGLTAALITGGLPALDATATEVYEAAYPRVERKNLAHYARYPMDVERARRIAAHLAERPAELPGGHRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPU8</accession>
    <name>A0A0F4IPU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001383">
        <property type="protein sequence ID" value="KJY23709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23709">
        <property type="protein sequence ID" value="KJY23709"/>
        <property type="gene ID" value="VR44_37525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4925"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="28867" checksum="0E2AFDC9FB411C1E" modified="2015-06-24" version="1">MGGTAAFGGEPDSARGYLLDNARAKAGERFVWLADLFDGVTRGHFDRLGVKAGWRCWEVGAGGPGIPEALAAAVGPTGHVLATDIDPSWLGAGDGYEVRRHDVAADPPPEPGTFDLVHARLVLVHVPDRARALATMAAALRPGGLLLVEDADTALQPLACLDDSGPAQRRANRLRDAVRELLARRGADLRYGRTLPRALREAGLVDVAAAGSFPVGGPACDRLEAATIRHVRGELLAAGLTDDAEIDAHLAAVEAGELDLTLAPLISVWGRRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ00</accession>
    <name>A0A0F4IQ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001298">
        <property type="protein sequence ID" value="KJY24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951938.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24077">
        <property type="protein sequence ID" value="KJY24077"/>
        <property type="gene ID" value="VR44_36380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4528"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26144" checksum="BFFE4B87A6775E3F" modified="2015-06-24" version="1">MPIRAVLWDIDDTLFDYTGADAAGLARHLRDEGLGDRYGTPAEALALWRKATELHWGRFSAGEVTFQGQRQDRVRDFLGEPALTAAEADAWFERYVGHYRAAWTLFPDVLPVLDALAGSHRHGVLSNSSEANQDPKLRHLGLRDRFEVLVCAAELGVSKPDTAAFLAACAALGLPPAEVAYVGDQPEIDARGARDAGLTAVWLDRDGRRGPGPGGVHRIEGLGQLPGLLAADTRFGARSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQL1</accession>
    <name>A0A0F4IQL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001363">
        <property type="protein sequence ID" value="KJY23783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952105.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001363.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23783">
        <property type="protein sequence ID" value="KJY23783"/>
        <property type="gene ID" value="VR44_37280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4848"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="290" mass="31394" checksum="C55AADB96E6BF39C" modified="2015-06-24" version="1">MMLVTGATGTIGREVLRRLAPDVPVRVMARQPARVTGAPGKAETVRGDYDEPESLDRALRGVDSVFLVTSRIGRDDDARFLRAARAAGVRHVVKLSAAAVEDGRADDLITRWQRDNEDLLRGSGMEWTLLRPRSFMSNTLSWASSIRSDGVVRALYGKSANACVDPRDIAEVAVRALTEPGHAGRAYVLTGPAALTATEQTAQLSELLGRSLRCEELDPAEARSLWGTRYPEAVAEALLRSAERQRDGAKAGVRDTVEEVTGRPAGTFRAWAAGHLTAFMPHRSAVGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQV3</accession>
    <name>A0A0F4IQV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001342">
        <property type="protein sequence ID" value="KJY23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952058.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001342.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23873">
        <property type="protein sequence ID" value="KJY23873"/>
        <property type="gene ID" value="VR44_37020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="135"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="43459" checksum="1AE0D56C467566ED" modified="2015-06-24" version="1">MEDVRIGVLGYGLRGALARTAHRPGRGAVVAALADPDPGARDRAAAAFSGARIHADPREVIGDPGIDAVLVLTPDHTHAELAVRALRAGRAVFVEKPLDIDVERCDEVLRTAYETGSRLYVGHNMRHMPVVRLMRELIARGAVGAVKTVWIRHFVGYGGDWYFKDWHAERRFTHGLLLQKAAHDLDVLHWLAGSYTEEVQAMGDLMVYGGIPHRRAAGEPKTADWYTEEGHWPPGTQRDLNPVIDVEDVSLMNLRLGNGVLAAYQQCHFTPDYWRNYTVIGDAGRLENFGDGPGAEVRVWNARRSGYRAEPDARHPVPAAPSEGGHGGADPLLIDEFLRFVREGGPTDTSPVAARMAVAAGYGATQSLRDGGTPLRVPPLDPLLAAYFENGQRRNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRD9</accession>
    <name>A0A0F4IRD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001205">
        <property type="protein sequence ID" value="KJY24557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951683.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001205.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24557">
        <property type="protein sequence ID" value="KJY24557"/>
        <property type="gene ID" value="VR44_35020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4078"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="27272" checksum="45C4003EA8E98D16" modified="2015-06-24" version="1">MQSSLFGHAEQQSQERYAVQNPQLLRVTLAGSDDVLARKGSMVAYQGIVDFDGEYQSSNQRGARLRTGEGLDLMRCSGQGTVYFANLAQHVHVLDVDHEGLTVDSSYVLAMDSTLHTEVIAVDSQYGISGSGKYQLNITGRGKVALMTSGQPLMMQVTPDKYVNVDADAIVAWSTSLRVQMQAQTHSSGVWRRRGNTGEGWELSFLGTGFALVQPSEVLPPQNAQLGQGIAAQYGMGQHGVHAQNQNNVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRW9</accession>
    <name>A0A0F4IRW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001172">
        <property type="protein sequence ID" value="KJY24765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951567.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001172.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24765">
        <property type="protein sequence ID" value="KJY24765"/>
        <property type="gene ID" value="VR44_34360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3850"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="13709" checksum="79A82ADC74B783DC" modified="2015-06-24" version="1">MTAPAAATAPAPAPAPAPFPAPDLVTVSVRQGLEAVDIIRRGAGRAAPAVGPVLHDGSGDTLGFLVPPGTADAWDLPGSACTQTNGRGMRFGDLATPTAGGTGWLLPPEAVGPVTDPEVLRAALGEAARLIEAADNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL4</accession>
    <name>A0A0F4ISL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001140">
        <property type="protein sequence ID" value="KJY24982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24982">
        <property type="protein sequence ID" value="KJY24982"/>
        <property type="gene ID" value="VR44_33775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3676"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19605" checksum="FC2894F55A97F26A" modified="2015-06-24" version="1">MAMFWNGNTGRKGECPGSTVGHSWQGYPFVLPHLNDVKNVVVTLHRILNDNTGDDPGNGLEISGRFDVARLCFGPEAGKLITLGSFNLFDRPGSDPQEIIEGTEFPVERDQQLMIFPGEFLWITGKLLEQDTFGEDDLGDRDIRIPFDALTNTPIDLGVFADGHDQRVIVTMSTRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITC0</accession>
    <name>A0A0F4ITC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001150">
        <property type="protein sequence ID" value="KJY24904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951496.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001150.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24904">
        <property type="protein sequence ID" value="KJY24904"/>
        <property type="gene ID" value="VR44_33995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3724"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="61"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27884" checksum="A9995770EDE2BCA6" modified="2015-06-24" version="1">MSDDWTRDPAAAEPAEGPAWSGSDGAQAFAAVEAATDWLLGYPFVFRALSRRGIGAGSVLVDYGCGPGKVADRAARLLGARVIGVDTSPEMLALARAPGTAVAEFHLVEGGRTGGLADGCADAAMCSHVLASLPDEEAVLSVFTEVRRLLRPGGPFVLLSTDPDCGGTEYASLRIGGPGTVHAPGQGLTVRLRRTDGTWQEVRNHAWPVGRIPGLLERAGFRDVVQERPTVEQALDTADPELVRSRPWTGERERPPLVVTTALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITR1</accession>
    <name>A0A0F4ITR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001078">
        <property type="protein sequence ID" value="KJY25410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7176"/>
    <dbReference type="EnsemblBacteria" id="KJY25410">
        <property type="protein sequence ID" value="KJY25410"/>
        <property type="gene ID" value="VR44_32575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8584" checksum="0BAE6E2466797E7E" modified="2015-06-24" version="1" fragment="single">MGDVMDFGMPGSTHAPAELAWLRGVDACTMGAYPQAEEEFRTAVGLDPSMADAWLGLHALRVDTTNALLRMYAHRDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU02</accession>
    <name>A0A0F4IU02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VR44_33870</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="JZWV01001143">
        <property type="protein sequence ID" value="KJY24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951473.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001143.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene600"/>
    <dbReference type="EnsemblBacteria" id="KJY24953">
        <property type="protein sequence ID" value="KJY24953"/>
        <property type="gene ID" value="VR44_33870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3698"/>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="253"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="438"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJY24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="556" mass="57483" checksum="A3A952865EF4FC6D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU40</accession>
    <name>A0A0F4IU40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001270">
        <property type="protein sequence ID" value="KJY24206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24206">
        <property type="protein sequence ID" value="KJY24206"/>
        <property type="gene ID" value="VR44_36025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4363"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="19007" checksum="B544F6887927E2A2" modified="2015-06-24" version="1">MTVASTTASAAPSPLAGSTTVTPAGHAFKAALTGKATLKAGSVTVTCSVSVSTGSVPAAPGNQNPAGAVASPISPPTYSSCTSSMPGVTPTVTTSGSWSVSMQNGSPITATMTVPTGGLVVHTTGLATCTVTAAPGGPASVPGSWANGAPSSLTFTNASVPVTVTGGFGCPTSATSSTFNAVYLVSDTTDPAQQITVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF8</accession>
    <name>A0A0F4IUF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ORF">VR44_35700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001249">
        <property type="protein sequence ID" value="KJY24321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951808.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001249.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3788"/>
    <dbReference type="EnsemblBacteria" id="KJY24321">
        <property type="protein sequence ID" value="KJY24321"/>
        <property type="gene ID" value="VR44_35700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4291"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="48"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="25723" checksum="E891FEABC46FCDC3" modified="2015-06-24" version="1">MTTVQDARLTELKELAERAGRELEDASALEILTWAAETFGAKFCVTSSMEDAVVAHLASRAFPGVDVVFLDTGYHFEETIGTRDAVQAVMDVNVITLTPRQTVAEQDAEYGPELHDRDPDLCCALRKVKPLEEGLTAYEAWATGLRRDESPTRAGTPVVGWDEKRQKVKVSPIARWTQDDVEAYVAEHGVLTNPLLMDGYTSVGCAPCTRRVAEGEDARAGRWAGRGKTECGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUV0</accession>
    <name>A0A0F4IUV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001024">
        <property type="protein sequence ID" value="KJY25792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951057.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25792">
        <property type="protein sequence ID" value="KJY25792"/>
        <property type="gene ID" value="VR44_31615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3031"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="160"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Gmad1" evidence="4">
        <location>
            <begin position="308"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="578" mass="61655" checksum="9C697FDBDE1CA6A0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV50</accession>
    <name>A0A0F4IV50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001065">
        <property type="protein sequence ID" value="KJY25499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25499">
        <property type="protein sequence ID" value="KJY25499"/>
        <property type="gene ID" value="VR44_32335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3268"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13510" checksum="34DB32A889AA6F70" modified="2015-06-24" version="1">MTSTNPLRLRIDGAAGSAAPYEQLRAQIADQARSGRLPVGFKLPTVRGLAEELRLAANTVAKAYRALEADGVIETRGRNGTFVAAAEGSSREAALAAQSYADRAHRLGLTEAEALSAATAALRARYAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV67</accession>
    <name>A0A0F4IV67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001204">
        <property type="protein sequence ID" value="KJY24566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951680.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24566">
        <property type="protein sequence ID" value="KJY24566"/>
        <property type="gene ID" value="VR44_35000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4049"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27405" checksum="498D350706E9906A" modified="2015-06-24" version="1">MTDTPESPAVRVERAGAVTTVVLSRPGARNAVDGPAARQLAEAFRDFEADEEASVAVLWGEGGTFCAGADLKAVGTGRGNRVEPDGDGPMGPTRLRLTKPVIAAVSGHAVAGGLELALWCDLRVVEEDAVFGVFCRRWGVPLIDGGTVRLPRLIGESRAMDLILTGRPVPAAEAHAIGLANRLVPPGQARPAAEELAREIAAFPQLCLRHDRLSVREQHGLAEPEALANELRHGTVPLSAGETLAGARRFASGAGRHGSFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVW8</accession>
    <name>A0A0F4IVW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000974">
        <property type="protein sequence ID" value="KJY26180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950895.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000974.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5077"/>
    <dbReference type="EnsemblBacteria" id="KJY26180">
        <property type="protein sequence ID" value="KJY26180"/>
        <property type="gene ID" value="VR44_30735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2603"/>
    <dbReference type="eggNOG" id="ENOG5031K3Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24443" checksum="4C82D90C13D891E6" modified="2015-06-24" version="1">MARKSNAETAANPGRLKQIALTYKMTSKADPKVGLIVAGVGIVTFGVFLAIGFLIGHPVYLGILGFLVAFLAMAIVFGRRAERAAFGQMEGQPGAAAAVLDNVGRGWTTTPAVAMNRNQDIVHRAVGKAGVVLIAEGNPNRVKSLLAAEKKKLARIMPDVPVHDFIVGTGEGEVPLKKVRTTLLKLPRVLPGDQITIVNDKLRAMGDLMSNMPIPKGPVPGRGMRGQRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW31</accession>
    <name>A0A0F4IW31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000970">
        <property type="protein sequence ID" value="KJY26217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26217">
        <property type="protein sequence ID" value="KJY26217"/>
        <property type="gene ID" value="VR44_30610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16504" checksum="87B472FA23D343DF" modified="2015-06-24" version="1" fragment="single">MTAPDTATRPLPPDVEQAEAAIVEHYPRLVRLAYLVLPPSLGRNRRVLTAHSLAQRALPRGRRATDAAAVQGGVPAQRGGLGGPESGYAYVRLRVLRSALEAGVPLTFKALPLRGQLPALLPQVWGLRLFPRAGGAEELALDQWLATLNGPGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWK4</accession>
    <name>A0A0F4IWK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000998">
        <property type="protein sequence ID" value="KJY26004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26004">
        <property type="protein sequence ID" value="KJY26004"/>
        <property type="gene ID" value="VR44_31070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2669"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="12979" checksum="E91F33F072D1CB17" modified="2015-06-24" version="1" fragment="single">QTPLRETSLLDAEVHVEASGNPAATLPVIERHLRPGARCLVVSRTDLAALIDSNPWVSHAARLIGARGHCGGIYPYLLNLFLAGRLDPTALVGATLSLEEVPAALARGATATSAGKTIVRVSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXC1</accession>
    <name>A0A0F4IXC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000984">
        <property type="protein sequence ID" value="KJY26093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26093">
        <property type="protein sequence ID" value="KJY26093"/>
        <property type="gene ID" value="VR44_30875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2677"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16379" checksum="7F29335DBCF53B49" modified="2015-06-24" version="1">MPLLFEAIITAETPRDMIGYTLDDHVEGDTIIFECTPPAVGVIMAALAGDLSALARDVLLQTLLFVAAGSGDYELEAEGAGLADRCRTHAQEGFWRLLKIGLTGTAEDAETIADICEYFELGGDKAAFYQAELRDRVRAKTKRGRRRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXF1</accession>
    <name>A0A0F4IXF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001087">
        <property type="protein sequence ID" value="KJY25356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25356">
        <property type="protein sequence ID" value="KJY25356"/>
        <property type="gene ID" value="VR44_32700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045401">
        <property type="entry name" value="GAP1-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045402">
        <property type="entry name" value="GAP1-N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20014">
        <property type="entry name" value="GAP1-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20013">
        <property type="entry name" value="GAP1-N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAP1-N2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GAP1-M" evidence="2">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21712" checksum="00E43982A7EA4CB6" modified="2015-06-24" version="1" fragment="single">MSEALLREAEPLLGYEPPPGPGRPEALSLSLLPDGSRLLARAVRTGSGFHAHAVHLPGAEARGALPVTAWGSADWQERTPADGPPAALDRIPAPGPYDRAAMAEFVAARGAWLAAFFDDVRRVAEEPGAPKVVLVEAEAADVARWVMLACGVLPHARGQWLSFTTYTRQPLSAPQQLVGVQPQDTGALAVGGRRHRVYDLSLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXG6</accession>
    <name>A0A0F4IXG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951247.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25371">
        <property type="protein sequence ID" value="KJY25371"/>
        <property type="gene ID" value="VR44_32640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3337"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HA" evidence="2">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="14341" checksum="E2F35ECA789078B7" modified="2015-06-24" version="1">MTRHGEAIGRWLATQRRDWARLNTEQQTRLTKLGVTPARVVHARSAPAKTSTTTTSGRGAEAFHKGVQALAQYRAREGGGTPGRGHVERLPDGSEHRTGVWVANQRQRRDRLDPAQLEALSALGQEWAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXV7</accession>
    <name>A0A0F4IXV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG</name>
        <name evidence="2" type="ORF">VR44_30380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000957">
        <property type="protein sequence ID" value="KJY26298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950829.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000957.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4976"/>
    <dbReference type="EnsemblBacteria" id="KJY26298">
        <property type="protein sequence ID" value="KJY26298"/>
        <property type="gene ID" value="VR44_30380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2488"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="32779" checksum="EA550D8DC6DFC49C" modified="2015-06-24" version="1">MSLPLEGLSAIVTGAGRGLGRAEALELARLGASVVVNDFGQSGRDGSGEASAAPAEEVAAEIRAAGGQAVAHLGDVADFEQARELVELAVSSFGKLDVLVNNAGILRDRMVFSMSEDEWDSVIRVHLKGHFNTTHFASAHWRERSKAAGGPVYGRIVNTSSEAFLGGSAGQPNYAAAKGGIVGLTTSTALALAKYGVTANAICPRARTRMTEDVFAGFQVPEEGRLDPLAPEHVAPLVGYLASPASARANGQLFVVHGGIVVVMERPRVAAKFDTSKEVFSFEELDSLLSPHYASRPANETFAAAEVLGLKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY86</accession>
    <name>A0A0F4IY86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_31960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001042">
        <property type="protein sequence ID" value="KJY25641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951122.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001042.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5915"/>
    <dbReference type="EnsemblBacteria" id="KJY25641">
        <property type="protein sequence ID" value="KJY25641"/>
        <property type="gene ID" value="VR44_31960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3107"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="42451" checksum="100C9B268779A815" modified="2015-06-24" version="1">MSSAPKNPFVPTDPLGLDELLSPEDLAVRDTVRTWAADRVLPHIAQWYEAGELPGIRELARELGSIGALGMSLTGYGCAGASAVQYGLACLELEAADSGIRSLVSVQGSLAMYAIWKYGSEEQKQRWLPGMAAGELIGCFGLTEPDVGSDPAAMRTHAKREGSDWILNGRKMWITNGSVASVAVVWAQTDEGIRGFAVPTDTPGFSAPEIKHKWSLRASVTSELVMDDVRLPADAVLPGVTGLKGPLGCLSHARYGIVWGAMGAARASFEAALDYARTREQFGRPIGGFQLTQAKLADMALELHKGILLAHHLGRRMDAGTLRPEQISFGKLNNVREAIDICRTARTVLGANGISLEYPVMRHATNLESVLTYEGTVEMHQLVLGKALTGLDAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYN0</accession>
    <name>A0A0F4IYN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000905">
        <property type="protein sequence ID" value="KJY26769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950629.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000905.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26769">
        <property type="protein sequence ID" value="KJY26769"/>
        <property type="gene ID" value="VR44_29270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2203"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19174" checksum="EF88FE6C281D3B92" modified="2015-06-24" version="1">MSAPSRAYRYVGPHHVIAAVQTANSGAPIRTPADFADWAAAQSAGELKEPLTFVIGTDGALLLAPRRSEHAACAGGGLVLSAGEVSFASEAGRWIVTEVSNQSTGYCPDVASWPAVAQALDQAALDHPDYFTHPVLFRRCPGCHRHNIVREGHFVCVFCDADLPRRWNVDTNVRDPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYN3</accession>
    <name>A0A0F4IYN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008743607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7406"/>
    <dbReference type="EnsemblBacteria" id="KJY26573">
        <property type="protein sequence ID" value="KJY26573"/>
        <property type="gene ID" value="VR44_29730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2325"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7400" checksum="3FE27171C3640F8A" modified="2015-06-24" version="1">MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVKLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYP2</accession>
    <name>A0A0F4IYP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000923">
        <property type="protein sequence ID" value="KJY26583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950704.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000923.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4954"/>
    <dbReference type="EnsemblBacteria" id="KJY26583">
        <property type="protein sequence ID" value="KJY26583"/>
        <property type="gene ID" value="VR44_29680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2313"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="26927" checksum="7DD80CD0C3D35D12" modified="2015-06-24" version="1">MLTVDFSRFPLAAGDRVLDLGCGAGRHAFECYRRGAQVVAVDRNGEEIREVAKWFAAMKEAGEAPAGATATAMEGDALALPFPDESFDVVIISEVMEHIPDDKGVLAEMVRVLKPGGRIAVTVPRYGPEKICWALSDAYHEVEGGHIRIYKADELLGKMKQAGLKPYGTHHAHGLHSPYWWLKCAFGVDNDKALPVKAYHKLLVWDIMKKPLATRLAEQALNPLIGKSFVAYATKPHLPVGTAGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ57</accession>
    <name>A0A0F4IZ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-linked alkanal monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001007">
        <property type="protein sequence ID" value="KJY25941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene873"/>
    <dbReference type="EnsemblBacteria" id="KJY25941">
        <property type="protein sequence ID" value="KJY25941"/>
        <property type="gene ID" value="VR44_31195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2727"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="369" mass="38362" checksum="8EB3F4D3DC724B39" modified="2015-06-24" version="1" fragment="single">ARHAAAGAGAPEAAAGDPVRGTVRGTAPVPLSVLDLVTVGAGSTAHASLRTSVELSRLAESRGYHRHWVAEHHSMPGVASSSPAVILAHLAAHTSRIRLGSGGVMLPNHAPLAVAEQFGTLEALAPGRVDLGLGRAPGTDPRTAAALRGPGRLDEAADEFPRRLAELTRFLDDDFPDGHPYSRVHAVPGPVQGPAARPPVWLLGSSGFSARLAGEHGLPFAYAHHFSAAGTLPALDLYRQSFRPSAVLDAPYALIGVAALAADTEEQARAQVLTGALSMLRLRSGRPGLVPTPEEAAAYPFSPLEREFVDGWLANIVHGTPDEVRSGLDALAARTGADELMLTTNAHSGAARLRSYELVADAYSMPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZF6</accession>
    <name>A0A0F4IZF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_29045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene544"/>
    <dbReference type="EnsemblBacteria" id="KJY26868">
        <property type="protein sequence ID" value="KJY26868"/>
        <property type="gene ID" value="VR44_29045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2142"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY26868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="35893" checksum="3DD6B65E7A6EBBC3" modified="2015-06-24" version="1">MMEGAAASSGGSAPSATRGGEQKRSVEQVALLLFITVPFLALLAAVPLAWGRGVSWLDLGLMVFMYFLACHGITVGYHRYFTHGSFKAKRPLRIALAVMGSLAVEGPLVRWVADHRKHHKYSDHEGDPHSPWRFGETVPALMKGLWWAHIGWLFDEEQTDQQKYAPDLIRDPAIRRISRDFIYWTAVSLAIPPLVGGLVTMSWWGAFTAFFWGSLVRVALLHHVTWSINSICHAVGKRPFRSRDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVLRGQVDSSARLIRWFELAGWATDVRWPSGARIDARRRDKSSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0D4</accession>
    <name>A0A0F4J0D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000803">
        <property type="protein sequence ID" value="KJY27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27730">
        <property type="protein sequence ID" value="KJY27730"/>
        <property type="gene ID" value="VR44_26910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="47620" checksum="914B694C2F2FA3C9" modified="2015-06-24" version="1" fragment="single">MRKWLPLTAVCIGAFMLLVDVTIVTVALPDMAADMHTGFSGLQWVMDIYALALAALLLGSGSLADRIGRRRVYLGGLVLFAGASLVCGLADGPGALIAFRAVQGVGGAAMAATSMALLSASYQGRDRGVAFGVWGAVNGAAAAAGPIVGGLLTEHFGWRWIFFINLPLCALAVFVTLRAVAESRDPRARGLDLPGMAAFTVGAGALTYALIRAGEDGWTSPATLGLFALAAVAFAAFVLVELRGSHPMLDLSLFRSPAFAAVMTAGLLTSGAAFSYLMYVSLWLQSAEGMTPVGAGLALVPMSLAAFVVAAVAGRLLHGVSARLTIGGGLLLIGGGALLQAWMLDAGDSWPALVPGLALTGVGVGVSMPALAATAMGAVPPARAGMAGGVLNTSRQLGTALGIAVLGGVFHAGLADGLSGRPAGTADALASGGAGRLLGSVPGAREWIDAAFASGLRETFVVSGALGLAGGLIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0G3</accession>
    <name>A0A0F4J0G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,2-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000799">
        <property type="protein sequence ID" value="KJY27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950179.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000799.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27760">
        <property type="protein sequence ID" value="KJY27760"/>
        <property type="gene ID" value="VR44_26805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1519"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="39621" checksum="0AB33BDCD5A0FE7E" modified="2015-06-24" version="1">MTQTRQTFAAGSRLFSPARLGRLDLPNRLVMAPLTRNRAGADGVPGELMATHYAQRATAGLIIAEATTPNAVGQTYPHIPGIHTAAQAAGWQRVTRAVRDAGGRMFLQLQHGGRIGHPDTSGHVPLAPSAVPLPEPLHTSAGLQDPVTPRAMTEEDIRSTIADFARAARNAVAAGFEGVEVHAANGLLLHQFLAPNTNLRTDAWGGSVEGRIRFAVEVVRAVGEAVGPERVGVRISPGVEVNGIEEPDLEELYPALLAALAELEPVYLHVEYADQERPGFAMLRRAWPGTLIANPKLSREEAAADGGAARGERLLAEGADLVALGRAFIANPDFVERARTGAPLNELRPEFLMHVHGAEGYNDYPALVPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0M2</accession>
    <name>A0A0F4J0M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lpp-LpqN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950155.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000793.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27830">
        <property type="protein sequence ID" value="KJY27830"/>
        <property type="gene ID" value="VR44_26670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1493"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15436" checksum="F25CA7ED1E1D017B" modified="2015-06-24" version="1">MSPEETAAVELLRRVPYGRVATSMRALPFLAVARHIVVGGRIVLRMHAGFGYHHACNGSVVSYGADNVNSGAPRLWSVQVTGTARLAEPTTAELELFGPAPHFVDGEVFDPVYMRIEPQFVTVHTLGAGNSGRYDRPRLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0M6</accession>
    <name>A0A0F4J0M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000851">
        <property type="protein sequence ID" value="KJY27293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27293">
        <property type="protein sequence ID" value="KJY27293"/>
        <property type="gene ID" value="VR44_27975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1844"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="17888" checksum="A4DF94E1ABFD4A43" modified="2015-06-24" version="1" fragment="single">LTLPAPVGSAPDPGLKLEKDSAVTVDTFLEEYDPSAREKMKQGFADNGLRQIVARGWTTPDGTRTRVYLLRFHGSGFADTFTGCGIDLNGVKGMEPDSAWEQARTQPAPDPSGISVLRESVPFGDEQTRVGCVQSGDVQALILQNRKGGAGAVPLHQAVILQRQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J259</accession>
    <name>A0A0F4J259_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000783">
        <property type="protein sequence ID" value="KJY27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950107.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000783.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27934">
        <property type="protein sequence ID" value="KJY27934"/>
        <property type="gene ID" value="VR44_26425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1469"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="111"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="31936" checksum="C9DE61A07B560AC8" modified="2015-06-24" version="1">MTTTAPESDLRRHELADFLRSRRERITPEQVGLARGRRRRTPGLRREEVAQLSAVGVTWYTWLEHAREIQVSPQVLDALARALLLDSTERAHLFALAGSTDPAPNTRCASVTPALRAMLDQLDPIPACVQNSRYDILAYNSTYGRLLCDLDRLPREDRNCLWLAFTNADWRASLADMPDVNRLLAAKFRASMAGHLAEPAWKALLARLDAASPEFREIWARHEVVGLGSNKKYIRNAHVGLLRLEHTSLWLGPAAGPRLTTFVPLDEETRLRLEELHSLSPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J291</accession>
    <name>A0A0F4J291_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000778">
        <property type="protein sequence ID" value="KJY27969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27969">
        <property type="protein sequence ID" value="KJY27969"/>
        <property type="gene ID" value="VR44_26355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12161" checksum="4C935D07E18E4BA4" modified="2015-06-24" version="1" fragment="single">MMGPAHSLSGAAAWLGVGAATAAAGHPMPWPVLVVGALICAGAALAPDLDHKSATISRAFGPLSRGLCEVVDKISYAVYKATRSPRDARRSGGHRTLTHTWLWAALIGAGSSALAVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J323</accession>
    <name>A0A0F4J323_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28264">
        <property type="protein sequence ID" value="KJY28264"/>
        <property type="gene ID" value="VR44_25775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1259"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="19031" checksum="651F3B3BA29ACB7B" modified="2015-06-24" version="1">MLPGAGQAMMMRQTLEGGLGVARATIVGNAVGLLLWSLSAAAGLSTLLLTNPGVYTVVRIAGGVVLVVLGINTLRAGRAGPTPPGRDGPRGGSWGAFGTGLATNLGNPKAGVFAVSVLPQFVTAHGSAFASIALLGAVWAFVNACWYLLFTWGVSRGRALMTRPAVQRGLRVVTGLVLLALGTAVAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J330</accession>
    <name>A0A0F4J330_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28103">
        <property type="protein sequence ID" value="KJY28103"/>
        <property type="gene ID" value="VR44_26080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1371"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="15005" checksum="2DC9D782E088ED3A" modified="2015-06-24" version="1" fragment="single">MVLGIDGGGSGLRAAVAAAAGGPVRATASGGAANVRSVPEPELTERLARVVGRVLPPGGAADLVSVVAGFAGAGIPGRAGDRGQHVAVRALRTALARHGCAPPHVRVAADSEIAFAAAPGCPPDGLAVIAGTGAAATRMRGHRLAATADGCGWLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3D5</accession>
    <name>A0A0F4J3D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28877">
        <property type="protein sequence ID" value="KJY28877"/>
        <property type="gene ID" value="VR44_24265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.833"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="24627" checksum="FAC2A21C62ADCCE2" modified="2015-06-24" version="1">MAADETAEGTPGAAAARRTLPATSWAVLGLLSFGEELSGYDLKKWSDWSLRFFYWSPSFSQIYGELKRLEKAGYASSRMVAQDSGTRDKRVYRITDAGMDAVRRWARETPVDPPVLKHGPMLRLWLGHLLEPEQMRELLLQQQEFAEGMRRGAEADVAAAQEEEAWAYPTLTLKWAERYYASERDLAAAMLEDLEDLEDIKARNTRPQPHTDTDTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3R5</accession>
    <name>A0A0F4J3R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000738">
        <property type="protein sequence ID" value="KJY28358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3633"/>
    <dbReference type="EnsemblBacteria" id="KJY28358">
        <property type="protein sequence ID" value="KJY28358"/>
        <property type="gene ID" value="VR44_25535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1205"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="25253" checksum="9EE142A035C499DA" modified="2015-06-24" version="1">MELFATKGYEATTVDEIAAAAGVARRTFFRHFRSKEEAIFPDHDDTLIRAEAVLEVAPAHEHPLDTVCRGIKEVMKMYAASPAVSVERYRLTREVPALREREIASVARYERLFTRYLLAHFDETDHHDGNDDPLLAEVAASAVVTAHNHVLRRWLRAGGQGDVETQLDHAFAIVRKTFGSGIGAGRSLGAAGAAPQAAVRAEGEVLVAVARTDAPLDEVMRTIEEALKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4J3</accession>
    <name>A0A0F4J4J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949537.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29277">
        <property type="protein sequence ID" value="KJY29277"/>
        <property type="gene ID" value="VR44_23365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.613"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11439" checksum="A5E5E50A0824D982" modified="2015-06-24" version="1">MTDGTDRPNNSQPGPASGGYGYPQPGQSNPYQPEPAAGQQGQGFGPPPVADESFPPPIPETFSATPTPDWQAMADASEAQRRKRRMLVIGGGVLAGSWSWSQRARRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J604</accession>
    <name>A0A0F4J604_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949300.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000615.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29792">
        <property type="protein sequence ID" value="KJY29792"/>
        <property type="gene ID" value="VR44_22055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.291"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="463"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="634" mass="65985" checksum="54C4772578DEBC79" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6D5</accession>
    <name>A0A0F4J6D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000652.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29338">
        <property type="protein sequence ID" value="KJY29338"/>
        <property type="gene ID" value="VR44_23160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="25811" checksum="68904D27EF3C400F" modified="2015-06-24" version="1" fragment="single">MPTPITAYELTGRTALVTGAAAGIGRATALLLAGAGAAVHCADRDERGLAETTALITKAGGTATAHPLDVTDRAALRAAVAAAGPLDITAAIAGVMHTSSVLDTTDEDLDRVLDINFKGVLRTCQEAVRAMIAAGRPGSVVTMASGAVDAAQPGLLCYSAAKAAVVQLTKTLATESGPHGIRVNAVAPGWIRTPMTARHTPEAQEQTEAAMIRMSPLRRVGEPEDIAHAVLYLASDASSFMTGQILRPNGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6U4</accession>
    <name>A0A0F4J6U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan binding domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949421.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29549">
        <property type="protein sequence ID" value="KJY29549"/>
        <property type="gene ID" value="VR44_22670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.466"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="36613" checksum="73532C0D0B1F16AA" modified="2015-06-24" version="1">MLGSLAVVVAATGGGYAVTAQPRADRAADDRHADGLPRRTEPVRRGDLSSGLTVEGTLGYAQERRLNAPGPGVLTWVAGAGTAVERDGRLYELGGRAVRLFYGATPMYRQLKTGDKGEDVKQLKRNLAALGYGTGLDADDATFTAGTATAVKRWQKAHKAAETGEVGKEDIAFASGPQRVQRADGQAGDEPGPGKPVLTLTGTERMVRFQLDAAKVGTARSGDPVTVTLPGGGTATGKIDSVGSTANPDGEGNGSGGGGGGGGGNGKPKVQVTVALDDAARVQGPDQSPVSVRLPGETREGVLSVPVNALLALAGGGFGVQVVENGAVREVPVELGMFGQGRVEVKGDALKEGMRVGVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7K7</accession>
    <name>A0A0F4J7K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949689.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28916">
        <property type="protein sequence ID" value="KJY28916"/>
        <property type="gene ID" value="VR44_24175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.787"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470800" evidence="1">
        <location>
            <begin position="22"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24358" checksum="11E97BD2CC06C9C2" modified="2015-06-24" version="1">MNSRQRRGVILLLLSAVCALAAFAGVLVVIGDVNSKVGAEVVAYRVKGDIAPYSALSAGQFEAVKVPKRWLSDTAVSDLGTLRGKIALTTLKKGSLLQSDMFVDKPQLQPGEQEIAIMIDAATGVAGKITSGAKVNIIATFKGAKESDPARSVIIVANARVLNVGKLTPLDKDGDKKGPAEAVPITFALNTKDTQRVAYAESFAEHVRLALVAPGTDSAPGAADRTYTLDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8N6</accession>
    <name>A0A0F4J8N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949132.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000589.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30108">
        <property type="protein sequence ID" value="KJY30108"/>
        <property type="gene ID" value="VR44_21190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8961"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="31"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="580" mass="62488" checksum="9039C99ACA972B22" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8P0</accession>
    <name>A0A0F4J8P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000586">
        <property type="protein sequence ID" value="KJY30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30159">
        <property type="protein sequence ID" value="KJY30159"/>
        <property type="gene ID" value="VR44_21085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8897"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="12978" checksum="5812F72BB90A5FD2" modified="2015-06-24" version="1" fragment="single">AFSNALATVLQRRASLTVPQSDGFRFGLVLDLLRRPLWLGGILAVIAAGVGQAAALATGALSLVQPLFVLELPLALLIASLMTRNRLPGAVWLAVAAVVAGLGVALVAASPAGNRTHVPLDRWVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8P7</accession>
    <name>A0A0F4J8P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger SWIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948946.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000555.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30565">
        <property type="protein sequence ID" value="KJY30565"/>
        <property type="gene ID" value="VR44_20170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8739"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="401" mass="42701" checksum="29327BD07C8C7255" modified="2015-06-24" version="1">MITARDDRRRTFETVPAGLEAVTWWGRAWVRALEERAPDAARLARGRAYASEGHVDAVTVTPGRIVAYVRGSRARPYRTELALSAFDDAEWTEVLEAVAADPAALAALLEREVPQSLAGRLLPGPGELGARCSCPDPARPPCKHAAALCYRAARLLDSDPFVLLLLRGRGERELLEDLARRNAAHAAREQPDAAADFPGVPARAALARTVLPPLPAPLAAPAVAGAPPAYPSDPAAPDPLALEQLAGDAAARALTLLTTGEDPIGGLGLWQDAVRLASAHPTAGLTGAARALYRDLARATGRTTTDLARAAAAWRQGGLPALTVLDEPWDPPAGPFDRARPLLLAAGLGSFRPGRNRLTDRTRQLRLGREGLWYAYESRPGTDDWWPTGRPSPDPVTALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAF8</accession>
    <name>A0A0F4JAF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948608.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31357">
        <property type="protein sequence ID" value="KJY31357"/>
        <property type="gene ID" value="VR44_18345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8218"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12559" checksum="A4E70BD32E960A34" modified="2015-06-24" version="1">MTENLRAGDAPARRAFVAPLVSTLLTLPMALVALFYTGISPMACDSCDTAAAHAFDASFRIAWPVFLAGLLGALVLLVCCWALPWRVRNTARRVGLAFAAPGLVVLATLVFTALVDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBR1</accession>
    <name>A0A0F4JBR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948649.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31244">
        <property type="protein sequence ID" value="KJY31244"/>
        <property type="gene ID" value="VR44_18555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8306"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="19094" checksum="0022174E4FB6E6CD" modified="2015-06-24" version="1">MTSYVRVRWYHEGAEYAVLFLSGLDDDRYEHLHRGQHHGSHATRIEVRTVHIVNVQAIEGTSNEVTFSSSIGQAWGHWHGDLPADGSAHVEIDIPEPVTTWQPADRPADALVGRPRSVVTICALVESVDDDGVVALRLASDIVLVDWEAVVPPPVGERIILTTATVELYPYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBS3</accession>
    <name>A0A0F4JBS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948676.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31193">
        <property type="protein sequence ID" value="KJY31193"/>
        <property type="gene ID" value="VR44_18660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8341"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="38177" checksum="008DFA0869998A62" modified="2015-06-24" version="1">METATARRGPLITAWSAVSPYGLERPEFTAGITAGRTAAAALDRGVWDGPVDTACLVPGFDSKTVLGRKGTRSMDRVTGLAVTAVGRLLQDPEGARIPGVGEDAGLVLGTNTGSAQSMMDFTRDSVVQEKPFYVDPMRFPNTVMNCAAGQCAIWHKLKGPNTTVAGGRASGLLALNYALRLQKSGHTRTVLCGAVEEFSPARAWLEFHTRRPDEADGILGEGAAVLLLESAEAAAQYGRPGLAEVLALEFGVFHTDAQVAPVLADSVRRALDRAAVQPPEVALVAASGAHGARGAAERESLDAVFAGHEPEHVPGAELIGDTHAASASFQTAALLATAEGRPGLAGSIGLITSVDRDGVVGCAVLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBT8</accession>
    <name>A0A0F4JBT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000504">
        <property type="protein sequence ID" value="KJY31274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948633.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000504.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31274">
        <property type="protein sequence ID" value="KJY31274"/>
        <property type="gene ID" value="VR44_18475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8290"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26643" checksum="92421D8FFD96E038" modified="2015-06-24" version="1">MAPLVHAAKATGITTLTLDSPANRNALSAQLVGELRAALAEAGKDTGTRAVLHTHGTRAVLLTHTGNTFCAGADLKSPCDPADFLALLRELTTLPKPVVARVTGHVRAGGLGVLGACDIAAAGPQSSYAFTETHLGLAPAVISMTLLPRLDPRAASRYFLTAEPFDAAEATRIGLLTLHTDGDPDTALAPVLDGLRKASPQALAETKAMVAAGVREALDRDGDRLSELSARLFASAEAREGITARFERRDPSWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBU2</accession>
    <name>A0A0F4JBU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">VR44_20520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000565">
        <property type="protein sequence ID" value="KJY30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949012.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000565.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1080"/>
    <dbReference type="EnsemblBacteria" id="KJY30426">
        <property type="protein sequence ID" value="KJY30426"/>
        <property type="gene ID" value="VR44_20520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8814"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="542" mass="56744" checksum="F7B19FF6E5A33634" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBV6</accession>
    <name>A0A0F4JBV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000509">
        <property type="protein sequence ID" value="KJY31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31228">
        <property type="protein sequence ID" value="KJY31228"/>
        <property type="gene ID" value="VR44_18605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8317"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase_C" evidence="1">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="18169" checksum="15EC804761D26B32" modified="2015-06-24" version="1" fragment="single">MKTQAVALDAFADPSRELLGKVGFGKVSVLRQPQRPQALPLPAMPELPPRVDMVMHHADGDPVLFNAAVAAGARGIVLIGTGAGNATPEIVQAVREAVARGVLVALTTRVPAGPVTEIYTHGGAVDIVAAGAVPTGTLRAGQARIAVLSALLATDDPAEQARVLRAALSEEDPALVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCB3</accession>
    <name>A0A0F4JCB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000461">
        <property type="protein sequence ID" value="KJY31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000461.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000025_gene6296"/>
    <dbReference type="EnsemblBacteria" id="KJY31855">
        <property type="protein sequence ID" value="KJY31855"/>
        <property type="gene ID" value="VR44_17285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7992"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="29326" checksum="94B79CF89FA3B78B" modified="2015-06-24" version="1">MAERLKKSGLIGELSAEFAGTMILILFGVGVVAQVVAGGALTDPPGGLGNHDSIAWAWGLGVTLGVYVAARLSGAHLNPAVTVALAAFKGFPWKHVAPYVVAQTAGAFVAALIVRWNYTEALAKADPTHTIKTQGVFSTLPANGNPNLPVTEWGALRDQIIGTAVLLLLILAVTDLLNTPPGANLAPFIVGLIVVAIGMAIGTNAGYAINPARDFGPRLASFLTGYGGAWRDQYGNFYFWVPIVGPLIGGLLGAGLYKFFVGRFLPTAEPEPPGEVPTPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCT7</accession>
    <name>A0A0F4JCT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948816.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30796">
        <property type="protein sequence ID" value="KJY30796"/>
        <property type="gene ID" value="VR44_19430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8495"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="38625" checksum="7D488F68A2C63A4C" modified="2015-06-24" version="1">MATTAPVHFRTTVPAAPRAHKAPRLRDLGPNWYASVMGTAIIANAGGTLPYQLPGQRAVCAFLWALSAVALAVLLGARALHWRHHPDQARAHLLDPAVAPFYGCLSMALLAVGAGTLIVGKDLIGQSPAVAVDAVLFTAGTVVGLVMAVVVPYLMVVRHKVEASQASPVWLLPVVAPMVSAAVGPLLVPHLPAGQPREALLLACYAMFGVSLLAVLLLLPLVFGRLITHGPLPLALTPALFLVLGPLGQSTTAVNQLADVAPGAIDAPYAGALGAFAVVYGVPVMGFALLWLALAAAMLVRAARDGMGFAMTWWALTFPVGTCVTGAAGLARHTGLDAFAWLAAALFLGLVTAWLLAAVHTLRGLLTGRLLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDT3</accession>
    <name>A0A0F4JDT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_18840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948702.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000515.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4117"/>
    <dbReference type="EnsemblBacteria" id="KJY31136">
        <property type="protein sequence ID" value="KJY31136"/>
        <property type="gene ID" value="VR44_18840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8379"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="202"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="414" mass="44800" checksum="3996F26BFBC0D0FB" modified="2015-06-24" version="1">MAATPSPPPAPPKPTWDPGQPEGPFPWLRPTIRIRLTLLYGGMFLIAGILLLSIIYLLAAQALREGNALPFKIVGGQKVEVSSSTCPGVGIDQSIEQFNAAIGQCILDQRKHALDDLLSRSLMALMGLSVIAFAFGYAMAGRVLSPLGKITRTARRVVGSDLTRRIELDGPDDELKELADTFDEMLDRLERAFTAQQRFVANASHELRTPLAINRTLLEVHLSDPGAPVELQQLGKTLLATNERSEQLVEGLLLLARSENQIVERKPVDLAEVASRAIDQARGEALAKGVEIRGERALAVVQGNGVLLERIALNLVQNAVRYNVPEGGWVEVTTEVQHGQAVLLVSNTGPVVPAYEVDNLFEPFRRLRTERTGSDKGVGLGLSIARSVARAHGGRILATPREGGGLVMRVTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEP2</accession>
    <name>A0A0F4JEP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_16220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000422">
        <property type="protein sequence ID" value="KJY32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948208.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000422.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32274">
        <property type="protein sequence ID" value="KJY32274"/>
        <property type="gene ID" value="VR44_16220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7667"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="496" mass="53358" checksum="471B4A29268D0A00" modified="2015-06-24" version="1">MYTDTDRCVRAVQSKDARFDGWFFTAVRTTGIYCRPSCPAVPPKVENMSFLPSAAACQQAGYRACKRCRPDTSPGSPEWNARADAVARAMRLIQDGVVDREGVPGLAARLGYSARQVERQLNAELGAGPLALARAQRAQTARLLIETSGLPMGDVAFAAGFSSIRNFNETVREVFALTPGELRARAARAGRQEPRVPGTLSLRLPYRAPLTPDNLFGHLVATAVPGVEEWRDGAYRRTLRLPHGSGIVALTPGPDHIGCRLALTDLRDLTIAISRCRWMLDLDADPEAVDEQLRTDPLLAPLVDEAPGRRVPRTVDAAEFAVRAVLGQQVSTAAARTHAARLVTAYGEPVEDPQGGLSHLFPSPEALAGLDPEALSMPRSRRATLTTLIAALADGSLPLGIDSDWEAARARLNALPGFGPWTTEVIAMRALGDPDAFLPSDLGVRKAARGLGLPSTPAALIARAAGWRPWRAYAVQYLWATDDHPINRMPAEGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF40</accession>
    <name>A0A0F4JF40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948172.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32393">
        <property type="protein sequence ID" value="KJY32393"/>
        <property type="gene ID" value="VR44_16035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7628"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="10139" checksum="32E62FBF80C938C4" modified="2015-06-24" version="1">MLERTLRKTHTEVTFILPADTPPGPVSVVGDFNDWQPGTHTLALRKDGKRAVTVKLPGENTYAFRYLAAGDYWFNDESAGDHDGPNSRLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK7</accession>
    <name>A0A0F4JGK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32101">
        <property type="protein sequence ID" value="KJY32101"/>
        <property type="gene ID" value="VR44_16675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="56" mass="6230" checksum="E5E1A9FD4685DFAD" modified="2015-06-24" version="1" fragment="single">MDRRVHRPLEDQEFDFITGMAQGTAVLAYFTGSWPKAVEASRALDAVVAEVAREYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGP1</accession>
    <name>A0A0F4JGP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_14850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000380">
        <property type="protein sequence ID" value="KJY32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947951.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000380.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32964">
        <property type="protein sequence ID" value="KJY32964"/>
        <property type="gene ID" value="VR44_14850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7367"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="60"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="298"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="724" mass="78398" checksum="EF6B6E4241CF5288" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGP7</accession>
    <name>A0A0F4JGP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000380">
        <property type="protein sequence ID" value="KJY32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947956.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000380.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2583"/>
    <dbReference type="EnsemblBacteria" id="KJY32969">
        <property type="protein sequence ID" value="KJY32969"/>
        <property type="gene ID" value="VR44_14875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7372"/>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="2">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27948" checksum="EAFBF5140BA4744B" modified="2015-06-24" version="1">MQRIRLRYTKRGRLRFTSHRDFQRAFERALRRAEVPMAYSAGFTPHPRVSYANAAPTGTGSEAEYLEIALAAPRDPETLRKLLDESMPLGLDIVDAVEARTSGLADRLTASVWELRLEGVEPAEAQRAVEAFLAAETVEVQRRTKNGMRTFDTRGAVVSLEALPAQVDRSPDNACAILRLVVRHLTPAVRPDDVLSGLHAVADLAPPVPAAVTRLAQGLFDEESGTVTDPLAPDREADTAAPPTAAVNADAKAPEGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGT3</accession>
    <name>A0A0F4JGT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malonic semialdehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000377">
        <property type="protein sequence ID" value="KJY33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947930.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000377.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33009">
        <property type="protein sequence ID" value="KJY33009"/>
        <property type="gene ID" value="VR44_14710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7269"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15068" checksum="7CCF06C87D154B3D" modified="2015-06-24" version="1" fragment="single">LVRSAEARERLVNLMSDGNKAKTAAAPLVAILAADNEFHEEFDTLLPHYPAVKGFFTERPAREAFAARNAMLQAAYFIVGIRAAGLAAGPMTGADLEGISKEFLDGDHSALMVVNIGKPGEGAWHDRSPRLSYDEVITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ08</accession>
    <name>A0A0F4JJ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34180">
        <property type="protein sequence ID" value="KJY34180"/>
        <property type="gene ID" value="VR44_12425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6544"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="173"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="42925" checksum="C2CD96F057247F47" modified="2015-06-24" version="1">MLAWVLDRSHEASARQVPALIEEAAQRLGLTGTRLYLSDLQQVRLVALPQLAAERPETAETAEADEQAEALDIDASLAGLAYRAQQVQTSRDRTTAWVPMVDGVERVGVMRATGPALDEQDLEGCLALAALATLIVISKSTHNDLLVERGRSRPMTLQAELLWAFLPPRTIGTSQATSTAVLEPAYDIGGDAFDHNFSDGGLHLTLLDAMGHDLAAGGASAAGLAACRSTRRAGGDLQDIATTIERTLRSWIPDRLMTGILAHLDTRRGEFAWINCGHPPPLLIRDGHVVPAALERPPQLPLGLGYHEDAPPPLHRARLQPRDRVLLYSDGVTEARSATGELFGEERLGDTVIRSMASGTTAPEALRRLILELLTHQDQRLHDDATILLCEWHPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ20</accession>
    <name>A0A0F4JJ20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000294">
        <property type="protein sequence ID" value="KJY34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947449.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000294.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34347">
        <property type="protein sequence ID" value="KJY34347"/>
        <property type="gene ID" value="VR44_12090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6503"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="148"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="22506" checksum="70496320EE016BCB" modified="2015-06-24" version="1" fragment="single">RTGALAELAGQPFGRVLVWAVGIGLVAMALWRCSEVLFGSVGPDGRKPAKRVAAAARTVFYAVTAFSALSFAAGRGGGRSSDEQSRDVTAQLLAVPAGPWLVGLAGLGIAVGGIVVVVGAARLTFREHMETGRLPRGARRAVDVLGVVGGVARGAVFTAAGAFLVHAAVSYDPRKAKGVDDTLRSFAQTPAGPWLLVAVATGLLLFGVFSWAMAAWPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLA6</accession>
    <name>A0A0F4JLA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947689.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33751">
        <property type="protein sequence ID" value="KJY33751"/>
        <property type="gene ID" value="VR44_13375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6911"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="33907" checksum="3ABDC901C7CFBE61" modified="2015-06-24" version="1">MVPPALLAKRRRAALRTAAFLSPWLIGFAVFFAYPLLSTAYFSFTRYDGFRPPAFNGTANWSYVFTDYPLFWPALRNTLWLVVVMVSCRVVFGLGVGLLVTRVKTGAGLFRTLFYLPYLAPPVAATLAFVFLLNPGTGPVDTLLDGTGLPAPGWFTDPGWSKPALTALALWGVGDLMVIFMAALLDVPKEQYEAAELDGAGPWARFRHITLPNISPIILFAVVTGVIQAMQYYTQPLVAGKAAAGVIGGSGQQFEPGYPDKSTLTLPQLVYNLGFQRFDYGAACVLALVLFALSMAFTALLMRRRGGLTGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLP6</accession>
    <name>A0A0F4JLP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">VR44_10795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947210.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35110">
        <property type="protein sequence ID" value="KJY35110"/>
        <property type="gene ID" value="VR44_10795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6009"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25622" checksum="3A5A9F23F85E6DF4" modified="2015-06-24" version="1">MPYEAPTHTVERSLRATTGAKVIAGVDEVGRGAWAGPVTVCAAITGLRRPPEGLTDSKLLTPRRRDELFDVLQAWVTAHALGHASPEEIDELGMTAALRLAAVRALDALPVRPDAVILDGKHDYLGTPWRVRTVIKGDQSCIAVAAASVIAKVQRDRMMAGLGEPGDGIEQFAFAANAGYPSPVHRAALEERGPTVHHRLSWSYLDALPQWRHLKKVRRSEESVELENGGQLGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLT5</accession>
    <name>A0A0F4JLT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947319.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34728">
        <property type="protein sequence ID" value="KJY34728"/>
        <property type="gene ID" value="VR44_11385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="567" mass="61293" checksum="3EAC3CF831FB9DE5" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMS5</accession>
    <name>A0A0F4JMS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000208">
        <property type="protein sequence ID" value="KJY35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35667">
        <property type="protein sequence ID" value="KJY35667"/>
        <property type="gene ID" value="VR44_09505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5302"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="28469" checksum="F81D8AB67AB4B255" modified="2015-06-24" version="1">MPVRTADAALAGVRRGVGAERLTGRTALVTGSSRGMGRAAAIRLAQEGALVAVHYNRDEAAAREVVTSVEKDGGRAFAVRGELGVDGDVDGLFAVLEEDLRERTGSTDLHILVNNAGVMGGVGADEVTPEQFDRIFAVNAKAPFFLIQRALRNMPDGGRIINISSGLTRFANPDEIAYAMSKGALEQLALHFAKALGPRRITINSVAPGITRNGNPVFDIPEVVEQMAGLSAFGRVGEPEDVADVVAFLATDEARWITGSFVDATGGTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMX4</accession>
    <name>A0A0F4JMX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="13" type="ORF">VR44_10660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000239">
        <property type="protein sequence ID" value="KJY35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947185.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000239.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000040_gene4442"/>
    <dbReference type="EnsemblBacteria" id="KJY35174">
        <property type="protein sequence ID" value="KJY35174"/>
        <property type="gene ID" value="VR44_10660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5879"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="602"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="689" mass="72207" checksum="D4238B8F0DA6CDA6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNQ3</accession>
    <name>A0A0F4JNQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000280">
        <property type="protein sequence ID" value="KJY34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947364.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000280.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3703"/>
    <dbReference type="EnsemblBacteria" id="KJY34556">
        <property type="protein sequence ID" value="KJY34556"/>
        <property type="gene ID" value="VR44_11635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6293"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="56"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="47512" checksum="0FCCB592E7A3B386" modified="2015-06-24" version="1">MADVPVELVLRSTRVITPEGTRAASVAVAGGKIAAVLAYEAEVPAGARLEDFGDDVLLPGLVDTHVHVNDPGRTEWEGFWTATRAAAAGGITTIIDMPLNSLPPTTTVDNLRVKQEVARTKAHVDVGFWGGALPDNVKDLRPLHDAGVYGFKCFLSPSGVDEFPLLDQEQLATSLAEITGFGGLLIVHAEDPHHLESAPQNPGPKYADFLASRPQDAENTAIENLIAQARRLNARVHVLHLSSASALPLIAAAKAEGVQITVESCPHFLTLTAEEVPDGATEFKCCPPIREAANQDVLWDALADGTIDCIVSDHSPSTADLKTGDFATAWGGISSLQLGLPAIWTEARKRGRTLEDVVRWMSAAPAALAGLAQKGAIEAGRDADFAVLAPEETFTVDPAELHHRNQVTAYAGRTLHGVVKSTWLRGAQIADHGTPTEPTGLLLERQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNS4</accession>
    <name>A0A0F4JNS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_08850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946849.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36007">
        <property type="protein sequence ID" value="KJY36007"/>
        <property type="gene ID" value="VR44_08850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5016"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="622"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="848" mass="90986" checksum="BA698CDF5C2ABE6E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP24</accession>
    <name>A0A0F4JP24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4">2.7.9.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, orthophosphate dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_11485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000268">
        <property type="protein sequence ID" value="KJY34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947338.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000268.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34691">
        <property type="protein sequence ID" value="KJY34691"/>
        <property type="gene ID" value="VR44_11485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="299"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="424"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="10">
        <location>
            <begin position="540"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="641" mass="68584" checksum="1181A50CF45BB7F0" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR00</accession>
    <name>A0A0F4JR00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ORF">VR44_08405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="JZWV01000173">
        <property type="protein sequence ID" value="KJY36178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946763.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5018"/>
    <dbReference type="EnsemblBacteria" id="KJY36178">
        <property type="protein sequence ID" value="KJY36178"/>
        <property type="gene ID" value="VR44_08405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4580"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY36178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="584" mass="63283" checksum="7B1CB1E6B34C1A2B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRB1</accession>
    <name>A0A0F4JRB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000164">
        <property type="protein sequence ID" value="KJY36389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946716.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000164.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36389">
        <property type="protein sequence ID" value="KJY36389"/>
        <property type="gene ID" value="VR44_08135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4376"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="36014" checksum="298C91B6D56A1301" modified="2015-06-24" version="1">MRTPNTPTPNPPTPNAPAATAGPALDVRGLRITLPGTARPVLDGVDLTVGAGETVALVGESGSGKSLTSRSALRLLPPGAVVEGVVRVAGRDVLTLDPAALRAVRSTAAAMVFQDPRAAVNPLRRIGDFLTEGVTLTGTMGRNEATARAGELLRAVGLDASVLRKYPGQVSGGMLQRVVIAAALMGDPVLLLADEPTTALDVTSQAEVIALLAALRERFGTGLLFVTHDLDLAAAISDRVYVMYAGRIAETGPAEELFARPRHPYTAALLASTPRMDGPRGRLAAIAGMPPDLRVELPGCAFAARCPLATEVCDREAPRPAAAPGRPEHRAACHHSDRLEGSAVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRN1</accession>
    <name>A0A0F4JRN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">VR44_07100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4623"/>
    <dbReference type="EnsemblBacteria" id="KJY36855">
        <property type="protein sequence ID" value="KJY36855"/>
        <property type="gene ID" value="VR44_07100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3763"/>
    <dbReference type="eggNOG" id="COG1828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="9049" checksum="0FA77EE284239256" modified="2015-06-24" version="1">MARVVVDVMLKPEILDPQGQAVQRALPRLGFEGIADVRQGKRFELEVEGEVDQAALDRIHKMAETFLANTVIEDFTVKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRY5</accession>
    <name>A0A0F4JRY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose 5-phosphate epimerase</fullName>
            <ecNumber evidence="2">5.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araD</name>
        <name evidence="2" type="ORF">VR44_06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.4" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000127">
        <property type="protein sequence ID" value="KJY36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946478.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2757"/>
    <dbReference type="EnsemblBacteria" id="KJY36930">
        <property type="protein sequence ID" value="KJY36930"/>
        <property type="gene ID" value="VR44_06850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3452"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="11"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="26139" checksum="E02606FBD6FE4B24" modified="2015-06-24" version="1">MSETDLKSLRREVLAANLRIPEAGLATLTWGNVSGVDRDAGVFVIKPSGVSYAELTEEDLVVVALEDGRVVDGHLRPSTDAETHRCLYRAFPSIGGVTHTHSAHAVAFAQARRPIPVLGTTHADTFNGPVPVTEDLTAEQCAKDYEYNTGQVIVARLGGDPRRAAEVPGALVSRHGPFTWGATAKAALENAIVCEAVAEMALHTLALGFRLGGVSEPPRHLLERHFTRKHGPDAYYGNPAPAPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSW5</accession>
    <name>A0A0F4JSW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946331.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37275">
        <property type="protein sequence ID" value="KJY37275"/>
        <property type="gene ID" value="VR44_06080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2552"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20734" checksum="F361C9B19EE6A431" modified="2015-06-24" version="1">MRKLTYFVATTVDGFIGAPDGDADFMYAYADQEFVGHLIAEYPETIAAAGRAHLGLADAEPKRFDAVIMGRNTYEPGLKAGMTSPYGHFREQYVVSRSLVEAPAADVRLISGDVAAEVRGLKARDGLGIWLCGGADLAAQLADEIDEYIVKTYPVVAGTGMPMSRVGFGVRPLELTGCTAFGGGQVITSYDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTV3</accession>
    <name>A0A0F4JTV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946116.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37792">
        <property type="protein sequence ID" value="KJY37792"/>
        <property type="gene ID" value="VR44_04910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1068"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7250" checksum="E276F5A1B566E4B8" modified="2015-06-24" version="1" fragment="single">RELDRLQAAVTGAKEAFAEAAGRIAVELGRGGNSAVARHLDVTPQHVSNLALAFKNKRADRAVADKGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTW4</accession>
    <name>A0A0F4JTW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="15" type="ORF">VR44_06285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene70"/>
    <dbReference type="EnsemblBacteria" id="KJY37193">
        <property type="protein sequence ID" value="KJY37193"/>
        <property type="gene ID" value="VR44_06285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3011"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY37193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="36020" checksum="7C27DF4B57FA105F" modified="2015-06-24" version="1">MLLDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLGKSDLLSDDEIVRLIRIAVTHLGITEVRFTGGEPLLRPGLVGIVEQCAALEPRPRMSLTTNGIGLKRTAQALKAAGLDRVNVSLDTLRPEVFKTLTRRDRHHDVIDGMAAAREAGLTPVKVNAVLMPGLNDDEAPDLLAWAVENEYELRFIEQMPLDAQHGWKREGMITAGDILQSLRTRFTLTEEGAEERGSAPAERWVVDGGPATVGVIASVTRPFCGACDRTRLTADGQVRTCLFATEESDLRSALRSGAPDEEIARLWKVAMWGKKAGSGLDDPSFLQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTY1</accession>
    <name>A0A0F4JTY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4 6">3.4.24.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_06090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4 6"/>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946347.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37294">
        <property type="protein sequence ID" value="KJY37294"/>
        <property type="gene ID" value="VR44_06090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2554"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014495316" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22223" checksum="AEF707970880544C" modified="2015-06-24" version="1">MLSAASVGLGVAAVLGGVVPTATAATPAGGSPASYAAYERSQENQAANKAFFEAVQRAVAEQRAANPSATAVVTVTYNTRNAPSFRTQIANSTRIWNGSVSNVKLQEVSSGGNFSYYEGNDSRGSYASTDGHGRGYIFLDYAQNQQYDSTRVTAHETGHVLGLPDHYSGPCSELMSGGGPGTSCTNPYPNSTERSRVNQLWANGLVGSGLGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU74</accession>
    <name>A0A0F4JU74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase VR44_05930</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946304.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37308">
        <property type="protein sequence ID" value="KJY37308"/>
        <property type="gene ID" value="VR44_05930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2400"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="44812" checksum="29F074C999A732D8" modified="2015-06-24" version="1">MALDTRVLQADEWDVWYDHLELAFGGVPESPEERTLYRSLTELDRSLGVWDGGTCVGSAGAFSFRLSVPGGAVVPAAGVTMVGVAPTHRRRGVLTSMMRRQLDDVRAAGEPVAVLTASEPEIYGRFGYGTASYDLVVDIDTTRVRLDVPPGADAVRLRLVDPLKALDDCERVYAALVAGRPGMPARQPGWERQGLLDPESHREGASPLKCVVAEDADGVVVGYARYRVRPDWEPSGSDGKVLVGEVDAVDPAAYAALWRYLFEIDLTWHVRAYRRPVDDPLLHLVNDVRRIRARQRDALHLRVVDLPGALEARGYGAAVDVVLEVEDAFCPWNAGRWRLTAGADGSGVRCVRTQDAAELELSVRELGSAYLGGVTLASLAGAGRVRELRPGALREASRAFAGDVAPWLPHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUG2</accession>
    <name>A0A0F4JUG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">VR44_04490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266917.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000060_gene2705"/>
    <dbReference type="EnsemblBacteria" id="KJY37982">
        <property type="protein sequence ID" value="KJY37982"/>
        <property type="gene ID" value="VR44_04490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.706"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="10763" checksum="6974C9950EC29A31" modified="2015-06-24" version="1">MPLDAATKKQIIAEFGAKEGDTGSPEVQVAMLSRRISDLTEHLKTHKHDHHSRRGLLILVGQRRRLLQYLAKKDIQRFRTLVERLGIRRGAAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUN0</accession>
    <name>A0A0F4JUN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946575.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36686">
        <property type="protein sequence ID" value="KJY36686"/>
        <property type="gene ID" value="VR44_07410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3955"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="13578" checksum="AA051FB562168BAE" modified="2015-06-24" version="1">MSDPQLPPRPEYHPGSAQPRLNRPVHERYPQIRPTSGYGDPRIRRTGPGPGAGTEQEPERSSKLNARLALALTVVIGQLWALTVTVNEWMKGNTATAWWGAGFLILSFLVVIALWLLDPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV30</accession>
    <name>A0A0F4JV30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946202.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7133"/>
    <dbReference type="EnsemblBacteria" id="KJY37598">
        <property type="protein sequence ID" value="KJY37598"/>
        <property type="gene ID" value="VR44_05385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1713"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="494" mass="52733" checksum="0E9C4CF66475ECC8" modified="2015-06-24" version="1">MTKRELSGHPLAHPGKLFIGGQWVPARDGRTEPDISPIDGQEIVPVAQAAATDADAAVAAARTAYEEGPWSRLSAQERALRLNRVGELIERDLEEIALLETVDMGKPFAFSSTVDAPMAAQLMHYYAGAVTRVDGSSRAPAGGQLAYTLREPLGVVCAITPFNFPLLLSMTKIAPALAAGNTVVHKPSPATPLTALKIAELFQEAEIPDGVLNVVTGPGVELGETLTGHPGIDKIAFTGSTAVGQSIIRKSAGTLKKVTMELGGKSANIVFADADLDAAEELAFFGIYYNKGEICTAGSRLLLQRPIHDELVERLVRRAAALKPGDPRDPQTLFGPLAHRAQFDKVSSYIEVGEKEGALLRTGGTGWTPEGASSQGLYFLPTVFTGVDNGMRIAQEEIFGPVLSIIPFDTEEDAVRIANDSAYGLAAGVHTKDLRRAHRVASQIKAGTVWVNCYNQYDPSVPYGGYKASGYGRECGPESLESYTQTKSVWIGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWC0</accession>
    <name>A0A0F4JWC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946341.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37286">
        <property type="protein sequence ID" value="KJY37286"/>
        <property type="gene ID" value="VR44_06145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2565"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="28703" checksum="EAF82D955F5346B3" modified="2015-06-24" version="1">MTHTATGSFGTDWQAWQDSWDRQQEWYMPDREERFRVMLDMVEALTGPAPRVLDLACGTGSITDRLLKRFPQARSTGLDLDPALLTIARGHFAGDDRVTFVTADLKDPDWPAALPYDSYDAVLTATALHWLHSEDLAVLYRRIAPLVRPGGVFMNADHMPDPSTPLINAADRAQRHAGMDRAKAAGVLDWRDWWALAAADPVLAEPTRARFAIYGEHADGDTPDEFWHARTLREAGFAEARTVWRSPSDALVLGLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXI8</accession>
    <name>A0A0F4JXI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000044">
        <property type="protein sequence ID" value="KJY38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945720.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38875">
        <property type="protein sequence ID" value="KJY38875"/>
        <property type="gene ID" value="VR44_02700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6846"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="29" mass="3142" checksum="72213AAB467E8B98" modified="2015-06-24" version="1">MTVENIVGLLVAVALLGYLVLALVKPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY18</accession>
    <name>A0A0F4JY18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945764.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38734">
        <property type="protein sequence ID" value="KJY38734"/>
        <property type="gene ID" value="VR44_02975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7327"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="36169" checksum="73F1DDAAE2422620" modified="2015-06-24" version="1">MTEQTTIARTELGKGGPVVGIQGLGCMGMSDFYGDTDETAARETLDAALAAGVTLFDTADAYGRGANEEFLAPFVAAHRDEITLATKFAIERNDDPAYRGIRNDRAYIRQAVEGSLRRLGVDVIDLYYMHRRDPAVPFSESVGTMAELVQEGKVRHLGLSEVTGAELREAYAVHPIAALQSEWSLFSRDVERSAVGAAAELGVAFVPYSPLGRGFLTGAFTDAEAELSAGDVRRGQPRFTGENARANAALLAPVREIAAAHGVTAAQVALAWVQQRAAVHGLTVVPIPGTRRPGRLAENTAATRITLTAADLALLEPLASRVAGTRYPDMTFTSVPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYE2</accession>
    <name>A0A0F4JYE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">VR44_01625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945515.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6523"/>
    <dbReference type="EnsemblBacteria" id="KJY39407">
        <property type="protein sequence ID" value="KJY39407"/>
        <property type="gene ID" value="VR44_01625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5726"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="18662" checksum="9F6BA0181FEAF829" modified="2015-06-24" version="1">MTDVRDALLQQIKDKAVVHGKVTLSSGKEADYYIDLRRITLDGEAAPLVGQVMLDLTAELDFDCVGGLTLGADPVATSMLHASAARGQRLDAFVVRKAQKAHGMQRRIEGTDVKGKRCLVVEDTSTTGGSPLTAVEAVREAGGEVVAVATIVDRGAAEAIAGAGLPYLTGYQLGDLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZR6</accession>
    <name>A0A0F4JZR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945272.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene998"/>
    <dbReference type="EnsemblBacteria" id="KJY39912">
        <property type="protein sequence ID" value="KJY39912"/>
        <property type="gene ID" value="VR44_00160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.30"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="43552" checksum="C65EFD6F36CFBCF2" modified="2015-06-24" version="1">MTSATPSSERRVSARIGAISESATLAVDAKAKALKAAGRPVIGFGAGEPDFPTPDYIVEAAVAACRDPKFHRYTPAGGLPELKKAIAAKTLRDSGYEVDASQVLVTNGGKQAIYEAFAAILDPGDEVIVPAPYWTTYPESIRLAGGVPVEVVADETTGYRVSVEQLEAARTERTKVVLFVSPSNPTGAVYNEADAKAIGEWAAEHGLWVLTDEIYEHLVYGDAKFTSLPVLVPALRDKCIVVNGVAKTYAMTGWRVGWVIAPQDVIKAATNLQSHATSNVSNVAQVAALAAVSGDLEAVAEMRKAFDRRRQTMVKMLNEIDGVYCPTPEGAFYAYPSVKELLGKEIRGKRPQDSVELAALILDEAEVAVVPGEAFGTPGYLRLSYALGDEDLVEGVTRIQNLLAEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0F2</accession>
    <name>A0A0F4K0F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_01660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39413">
        <property type="protein sequence ID" value="KJY39413"/>
        <property type="gene ID" value="VR44_01660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5733"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="36830" checksum="219900DFBC1BFA1B" modified="2015-06-24" version="1">MFAGVRGAGVLVITLGAWWADRNPVRVLGGSWDSYWYLSIAANGYGRTQMWPASDSIQSDSAFFPLYPVLTHLLGGGPVAGLAVAWTAAAVAAVGIYRVGERLLGARAGVLLVALWASLPHAVVLTLGYTEPLLCALAAWSLYALLRERWMWAASLAVLAGLTRPTGIAVAAAVSVLALRELLRGSRAPAVWAAGLLAPAGWVSYVLAVGARRHELFGYFTVQRQWGSRFDFGAGTVGVVDKVLTGGEVTIPVAVTVATLAVAGLLAVLLLLDRTPLPLLVYTAVLLVIALGGAGFFESKPRFLLPAFPLLLPVAAAMAKARPRTAVAVTVGMAGLSFGYGAYLTLLAKVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Q8</accession>
    <name>A0A0F4K0Q8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Pantothenate kinase</fullName>
            <ecNumber evidence="4 7 8">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="11" type="ORF">VR44_00450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4 7 8"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945305.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1059"/>
    <dbReference type="EnsemblBacteria" id="KJY39970">
        <property type="protein sequence ID" value="KJY39970"/>
        <property type="gene ID" value="VR44_00450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.88"/>
    <dbReference type="eggNOG" id="COG1072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="10">
        <location>
            <begin position="113"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="38479" checksum="C9D8A33B30EAB07C" modified="2015-06-24" version="1">MITSPTRCTPEHATERPGPRRVPEPSPYVDLTRAEWSALRERTPLPLTAEEVERLRGLGDVIDLDEVRDVYLPLSRLLNLYVGATSNLRGTLNTFLGDAGGNGHGAQQGTPFVIGVAGSVAVGKSTVARLLQALLARWPEHPRVERVTTDGFLYPMKELQRRGLTSRKGFPESYDRRALTKFVADIKAGKDEVTAPVYSHLIYDIVPDERLVVRRPDILIVEGLNVLQPALPGKDGRTRVGLADYFDFSVYVDARPEDIERWYLNRFRKLRETAFQNPFSYFRKYTQVSEEEALEYAQTMWRTINKPNLLENVAPTRGRATLVVRKGPDHKVTKLSLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1D5</accession>
    <name>A0A0F4K1D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945282.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39924">
        <property type="protein sequence ID" value="KJY39924"/>
        <property type="gene ID" value="VR44_00235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.45"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="25318" checksum="BB28851C44171B72" modified="2015-06-24" version="1">MDPAFLPGDGGLDDRVPFLARLENEDGTALRKLGREMQFAPRSPLIQQNEPSTHVLLILTGWTKVTASAPTGYQALLALRGPGDIVGESAAVTGSPRSATVTALERVRAVAIDHRAFREFLSGCPSAAFTLLGLTAERMRASDRRQLAHASMSVRERLATLLLDLARTHGRRSTGGVEIAVPLTKQELAGAVGASREMVQRALKDLRDRGVVSTGRRTVVIAQPDILRRIGRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I164</accession>
    <name>A0A0F4I164_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001871">
        <property type="protein sequence ID" value="KJY15770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15770">
        <property type="protein sequence ID" value="KJY15770"/>
        <property type="gene ID" value="VR44_40860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7284"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6171" checksum="502157B7B3B66DEA" modified="2015-06-24" version="1" fragment="single">ELGGAPGLAELLDAGTFEAILALLPEQAAEPSAAAPVPAPAPAPVPAPAPAPAPAPAPAPAPDAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I264</accession>
    <name>A0A0F4I264_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylhomocysteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001788">
        <property type="protein sequence ID" value="KJY16100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16100">
        <property type="protein sequence ID" value="KJY16100"/>
        <property type="gene ID" value="VR44_40605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6962"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="14134" checksum="FA51C6349AFD2ACA" modified="2015-06-24" version="1" fragment="single">VLIETLVALGAEVRWVSCNIYSTQDHAAAAIAAAGIPVFAWKGETLEEYWWCTEQALTWPGQTGPNMILDDGGDATLLVHKGVEYQKAGAVPDVSTADNEEMAIVLGLLAKTDIDWTALASGIRGVTEETTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I309</accession>
    <name>A0A0F4I309_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_40475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001758">
        <property type="protein sequence ID" value="KJY16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16395">
        <property type="protein sequence ID" value="KJY16395"/>
        <property type="gene ID" value="VR44_40475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="49"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="19170" checksum="A22D3C231EB66FBB" modified="2015-06-24" version="1" fragment="single">PLFADAVSFAVSALLVRSLPAVPRPVPQARESLLRQARAGASYVFRDRLLLGLALRPAVGNIAFLAVETVLALFAHDRLGIGSFGFGLLLTAEATGGLLGAGIASFLGRRLGTGTALTCTAAIEGLAILGLAASPNPYAAGLALAVCGAGMGATMVLAPSLRQTIVPPELMGRVASTSRMLAMCAAPFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I472</accession>
    <name>A0A0F4I472_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001716">
        <property type="protein sequence ID" value="KJY16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16790">
        <property type="protein sequence ID" value="KJY16790"/>
        <property type="gene ID" value="VR44_40295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6601"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="25426" checksum="EF830C7F22608FB3" modified="2015-06-24" version="1" fragment="single">VPTLAPGPGGLTPVFERTRQRTEKTVALTFDADMTSDQGPRAASGEHFDNPELIAALRRLKVPSTVFMTGRWAEEYPDQAKAIGTDPGFEIANHSYSHHAFKSPCYGLPALDAAAARADVDRAFAAFKKAGAVNTVAVNTVPYFRFPGGCYDEQALRALAPAKVTAVQWDVVSGDAFAKDPDAVAEQVLAGVKPGSVVVMHCTHSAAPVTEQAVEKIVPELRKRGYRFVKVSELMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4W3</accession>
    <name>A0A0F4I4W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001721">
        <property type="protein sequence ID" value="KJY16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952668.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001721.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16734">
        <property type="protein sequence ID" value="KJY16734"/>
        <property type="gene ID" value="VR44_40305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469548" evidence="1">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="27831" checksum="64139E13C289C1F0" modified="2015-06-24" version="1" fragment="single">LPLLQADCANCFALCCVALPFAKSADFAVNKAAGTPCKNLRQDFRCGIHTGLRDQGFQGCTVFDCFGAGQQISQVTFEGRDWRTHPETRQAMFDAFPVMRQLHELLFYLSAALGIPAAAPLHPALRELLTRTEGLTRADADTLTTLDVPALRQEINTLLLKTSELARAKTPGRKKNHRGADLMGARLAGADLRGANLRGAYLIAADLGRADLRGADLIGTDLRDTNLRGADLRDTLFLTQPQLNAAQGDPATRIPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5S2</accession>
    <name>A0A0F4I5S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001674">
        <property type="protein sequence ID" value="KJY17345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17345">
        <property type="protein sequence ID" value="KJY17345"/>
        <property type="gene ID" value="VR44_40015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6341"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="11010" checksum="E7C2BBDF00663322" modified="2015-06-24" version="1">MPGAVCGELLPCQQLVESDADVGGIGLEGAVDLGDEVMRCLGGVGGDGGAQGGDLLGEGEAVSGQGVLQDAAGGVVGQAENARVGGGGGAGRGGLLRFCSFGKGGDEMCVAAASSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6Y0</accession>
    <name>A0A0F4I6Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001648">
        <property type="protein sequence ID" value="KJY17785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17785">
        <property type="protein sequence ID" value="KJY17785"/>
        <property type="gene ID" value="VR44_39835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10515" checksum="3B0B58E0C8CA107B" modified="2015-06-24" version="1" fragment="single">MTPDVETGSGSERGLPPPKERRRLRESGELTHEQVATELGVTPGTVRSWETGRTEPGARTRAAYADLLDRLARAGAGRPGGSTTRPGRAAKRAPKPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8V7</accession>
    <name>A0A0F4I8V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001690">
        <property type="protein sequence ID" value="KJY17131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952635.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001690.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17131">
        <property type="protein sequence ID" value="KJY17131"/>
        <property type="gene ID" value="VR44_40135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6399"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="26858" checksum="CFFB18AD3F6B2547" modified="2015-06-24" version="1">MATRLVQINMKAHDDSALGRFWAEVLGWGIDSEGPGVTNLEPVGFSYPDPLAVCVDIIARPEPKTVKNRVHLDLATTSAAHQAELVARLKDLGATLADVGQGDVPWTVMADPEGNEFCVLEPREIYRDTGPVAAVVVDCSDPREMARFWGEVIDWKLHQVTDDLATMRSAQGVGPYLEFVRTPDTKTGWNRVHLDVAPYKGDDLAAEAARLRALGATDPDFDRSAIHWTVLADPEGNEFCLLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9G9</accession>
    <name>A0A0F4I9G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small membrane hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001611">
        <property type="protein sequence ID" value="KJY18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952543.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001611.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18319">
        <property type="protein sequence ID" value="KJY18319"/>
        <property type="gene ID" value="VR44_39605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6037"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15145" checksum="A718CE642376EFAF" modified="2015-06-24" version="1">MSLKKINTVLAAAFILFILWFGTEYILSPETTAPGYGLPGWPSGDGDGFLVVKGIRDVVLALVLGVLLVTGHRRALGWALMVEALAAYGDMTNVLAHHGSVAIALGVHCLTATLMVVNGLLIIRETSRAAAAAEAPARVRVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAJ2</accession>
    <name>A0A0F4IAJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_39250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001568">
        <property type="protein sequence ID" value="KJY19065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2220"/>
    <dbReference type="EnsemblBacteria" id="KJY19065">
        <property type="protein sequence ID" value="KJY19065"/>
        <property type="gene ID" value="VR44_39250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5651"/>
    <dbReference type="eggNOG" id="ENOG50348JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469354" evidence="5">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY19065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9045" checksum="CB9EDC4CE4574269" modified="2015-06-24" version="1">MQRTDLCGKDRIQMKYKKAVVMAAGVLVAAGAASPAMADAAADGKAVGSPGVLSGNLVQVPVHIPVNVCGNTVNVIALLNPAFGNVCVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IMP8</accession>
    <name>A0A0F4IMP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">VR44_37655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001397">
        <property type="protein sequence ID" value="KJY23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952174.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001397.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene36"/>
    <dbReference type="EnsemblBacteria" id="KJY23305">
        <property type="protein sequence ID" value="KJY23305"/>
        <property type="gene ID" value="VR44_37655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5036"/>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="10"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="267"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="506" mass="53315" checksum="DD95857F758A09D8" modified="2015-06-24" version="1">MSGTRRGGGLLVAGTTSDAGKSVVTAGICRWLARQGVKVAPFKAQNMSLNSFVTREGAEIGRAQAMQAQAARVEPTALMNPVLLKPGGDRSSQVVLLGKPVGEMSARGYHGGRQEQLLGIVTDCLEQLRGTYDAVICEGAGSPAEINLRRTDIVNMGIARAARFPVVVVGDIDRGGVFASFFGTTALLSPEDQSLIAGYLVNKFRGDVSLLEPGMEMLRSLTGRGTYGVLPFQHGLGIDEEDGLRVSLRGAVRESVVAPPVGQDVLRVAVCAVPLMSNFTDVDALAAEPGVIVRFVDRAEELADADLVVVPGTRGTVKALEWLRERGLAEALARRAAEGRPVLGICGGFQALGEHIEDEVESKAGSVAGLGLLPVRVRFAVEKTLARPVGTALGEEVAGYEIHHGVAEVLGGEPFLDGCRVGSVWGTHWHGSLESDGFRRAFLREVAAAAGRRFVPAPDTSFSALREEQLDLLGDLIEEHADTAALLRLIESGAPSGLPFLPPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ28</accession>
    <name>A0A0F4IQ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001292">
        <property type="protein sequence ID" value="KJY24102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951922.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24102">
        <property type="protein sequence ID" value="KJY24102"/>
        <property type="gene ID" value="VR44_36305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4510"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M6" evidence="2">
        <location>
            <begin position="83"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="785" mass="85394" checksum="81D493CCBF6B7D32" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQD8</accession>
    <name>A0A0F4IQD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001269">
        <property type="protein sequence ID" value="KJY24212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951870.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001269.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24212">
        <property type="protein sequence ID" value="KJY24212"/>
        <property type="gene ID" value="VR44_36020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470047" evidence="2">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="21723" checksum="374CD7603B7DD8CF" modified="2015-06-24" version="1" fragment="single">MSRISVRGFAVASATAVTTVGAVVGVATGDAATSNDLETTASGATLLTDIPVGEQAQVQSGSLAQQADALAHAADADAKRSAEEAARIQAAEDAKSKKADAQKAEQEKKDADAKKLKDERDAAEGIASRSATRDAGDFPVQGSYTVAQVKDIARQLVPSGQFQCFSNIINEESTWNYQAVNSSSGAYGLVQALPGSKMASAGSDWRTNPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQK1</accession>
    <name>A0A0F4IQK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001250">
        <property type="protein sequence ID" value="KJY24315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951812.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001250.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3783"/>
    <dbReference type="EnsemblBacteria" id="KJY24315">
        <property type="protein sequence ID" value="KJY24315"/>
        <property type="gene ID" value="VR44_35730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34701" checksum="786EE9A0109DE701" modified="2015-06-24" version="1" fragment="single">MQPAKETPDGTPARPGRLHRARVLYRNVSKRKMGWLLLKDTVNSCVEYRILGLAAEAAFFTLLSLPPLFLGLLGLLGYVDGWTNTQSVASIEENILRAVGTVLSDRGVNDIARPMLDDVTREGRPDLISLGFAFALWSGSRAVNVFIDTITVMYGLDGQRGIVKTRLLAFLLYVIALVIGAIVLPLMVVGPDAVVRLVPWSTEVIAVLYWPVVTLLSIAFLTTLYHVSVPVRSPWIEDVPGALVALAMWVLGSFLLRIYLTNTVEGPTIYGSLAAPVAVLLWIGISAFAVLVGAAVNAAIDRVWPSVATAAAREANERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQV2</accession>
    <name>A0A0F4IQV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001306">
        <property type="protein sequence ID" value="KJY24039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24039">
        <property type="protein sequence ID" value="KJY24039"/>
        <property type="gene ID" value="VR44_36500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4603"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470061" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6719" checksum="F1352941D83FDCAC" modified="2015-06-24" version="1">MKKTFPVTAAAAVVSLWTLAVAAHAAPAPVTQTYDRPGSYTFTVPDGVRRITEAAEAVGATTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQW9</accession>
    <name>A0A0F4IQW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_36440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001302">
        <property type="protein sequence ID" value="KJY24059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3609"/>
    <dbReference type="EnsemblBacteria" id="KJY24059">
        <property type="protein sequence ID" value="KJY24059"/>
        <property type="gene ID" value="VR44_36440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4540"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="6"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="24543" checksum="1A579857309479AF" modified="2015-06-24" version="1" fragment="single">GMLFLDLIQEGNVGLIRAVEKFDYTKGFKFSTYATWWIRQAITRAMADQSRTIRIPVHMVEIINKLARVQRQMLQDLGREPTPEELGKELDMTPEKVIEVQKYGREPISLHTPLGEEGDSEFGDLIEDSEAVVPADAVSFTFLQEQLQSILGTLSEREAGVVSMRYGLNDGQPKTLDEIGRVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR56</accession>
    <name>A0A0F4IR56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001222">
        <property type="protein sequence ID" value="KJY24472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951726.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001222.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24472">
        <property type="protein sequence ID" value="KJY24472"/>
        <property type="gene ID" value="VR44_35255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4160"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="25940" checksum="2D6DC2E2AF06CE0A" modified="2015-06-24" version="1">MDDLTLVRDHTIYSCVTGSRAFGLATEASDTDRRGVFLAPTPLFWRFEKPPTHVEGPREEEFSWELERFCELALRANPNVLECLHSPLVDRLTPVGEELVSLRDAFLSRRAHTTFSRYAVSQHRKLLADVRLHGAPRWKHAMHLLRLLLSCRDLLRTGRLDIDATPYRDRLLAVKRGELSWEEVDAWMTRLTEESESALTSTTLPAGPDLPRITDFLHRTRRASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRP6</accession>
    <name>A0A0F4IRP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">VR44_34605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001182">
        <property type="protein sequence ID" value="KJY24690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007263143.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001182.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3254"/>
    <dbReference type="EnsemblBacteria" id="KJY24690">
        <property type="protein sequence ID" value="KJY24690"/>
        <property type="gene ID" value="VR44_34605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3906"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="14398" checksum="931A1CB4F219982A" modified="2015-06-24" version="1">MARVKRAVNAHKKRRAILEAASGYRGQRSRLYRKAKEQVTHSLVYNFNDRKKRKGDFRQLWIQRINAAARQNGMTYNRLIQGLKAANIEVDRKILAELAVNDANAFAALVEVAQKALPADVNAPKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISN7</accession>
    <name>A0A0F4ISN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001185">
        <property type="protein sequence ID" value="KJY24669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951613.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24669">
        <property type="protein sequence ID" value="KJY24669"/>
        <property type="gene ID" value="VR44_34645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3914"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23292" checksum="A241C6886D5CEEE5" modified="2015-06-24" version="1">MCGVGLREIKKQQTRTAIADAALPLFLEYGFDRVTVAEVARHAGVSTNTVFNYFPVKEDLFFDRGADAEEHLAAVVRDRAPGACPVEAVCEDLLSGLRENHPMLGLQPGATAFWQVILDSPALLAREREIGERAEAALTAALTGHPPHTADAPGHCAPPPPALLAGAVAGMHRAALRELRQRIMAGEAPEEARDAVISAVVQGFDLICRGLHPTAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT62</accession>
    <name>A0A0F4IT62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001110">
        <property type="protein sequence ID" value="KJY25195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951342.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25195">
        <property type="protein sequence ID" value="KJY25195"/>
        <property type="gene ID" value="VR44_33165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3506"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15433" checksum="EDF63B6E7FA415AF" modified="2015-06-24" version="1" fragment="single">MPAQLRDSHCSTCGTPFDTTDWPRPCTACGAVTYRNPLPVAVALLPVEDAAGTGLVVITRTIEPAKGGTALPGGFIDFGEDWREAVVRELREETGIEAPAGEVTLADALSSPQGHLLLFGLLPPRPASALPPSAPTDETTGWHVLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUL9</accession>
    <name>A0A0F4IUL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001236">
        <property type="protein sequence ID" value="KJY24381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951780.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001236.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene894"/>
    <dbReference type="EnsemblBacteria" id="KJY24381">
        <property type="protein sequence ID" value="KJY24381"/>
        <property type="gene ID" value="VR44_35555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4224"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="30226" checksum="6DADBE5C12C7F9BB" modified="2015-06-24" version="1">MKLLRVGPAGSERPALLDQDGTLRDLSGLITDVDGALLADDSVLSRVRDAAAAGELPVLDGEGLRIGSPVGRIGKIVGIGLNYFGHAAEVGAEPPAEPILFLKAADTVVGPDDTVLIPRGSVKTDWEAELGVVIGSTARYLGSAEEGLAHVGGYTLVNDVSEREFQIERGGTWDKGKNCETFTPLGPWLVTADEIPDPQVLDVKLWVNGELKQDGNTSDQIFPVGEVVRYLSQFMTLYPGDVIVTGTPGGVAMGQPEPKPYLRAGDVVELEIEGLGRQRQEFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVZ6</accession>
    <name>A0A0F4IVZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001044">
        <property type="protein sequence ID" value="KJY25628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951130.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25628">
        <property type="protein sequence ID" value="KJY25628"/>
        <property type="gene ID" value="VR44_32010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3119"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="26217" checksum="7099331C43E5B9C3" modified="2015-06-24" version="1">MDLGLEGRVAVVTGASRGIGLAIVRALAGEGALVVAGARHSSAELDALVERGGVRLVRVDLAEAGGARRLVAAAGDRIDVLVNNVGSASARPSGFLGVTDEQWQQAINLNLFAAVRVTREVLPLMLERGSGSIVNICSVNSVDPMVIDYSVGKAALANFSKGVSKEVGGRGIRVNTVSPGPVETDLWLAGDGVAATVSRATGMTPREVAAQAAGATVTGRFSKPAEVADVVLMLASDRTGNVTGSDITIDGGFLTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW13</accession>
    <name>A0A0F4IW13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000969">
        <property type="protein sequence ID" value="KJY26225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26225">
        <property type="protein sequence ID" value="KJY26225"/>
        <property type="gene ID" value="VR44_30605"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6798" checksum="7A46737155AB7092" modified="2015-06-24" version="1" fragment="single">PDVLRVLAEAGVADPAAAVAESGDPAHDALFASPEFDPCVLQARPTDLLRRRRFARAAMAGAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWB0</accession>
    <name>A0A0F4IWB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001029">
        <property type="protein sequence ID" value="KJY25753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951074.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25753">
        <property type="protein sequence ID" value="KJY25753"/>
        <property type="gene ID" value="VR44_31710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3052"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20576" checksum="EFC071A1C71BB21A" modified="2015-06-24" version="1">MTTDLLDRKLERAFAHLDADDNGVIDEKDMIALGSRLLTALAEPADSPKAAEVFRGLTDFWVDLFNELGVGQDQKLTPEQYRDGMTRLYKDGGPAYEKSFRPMMKAMLTVVDTNGDGHISPEEFHKAQLAFDTRLEPAAADALFERIDKNHDGYLSVDELLDAVREYYTGEDEDAPGNLLFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ32</accession>
    <name>A0A0F4IZ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000907">
        <property type="protein sequence ID" value="KJY26738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000907.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26738">
        <property type="protein sequence ID" value="KJY26738"/>
        <property type="gene ID" value="VR44_29310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2213"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="32"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="459" mass="50072" checksum="99DC5E1282094DD1" modified="2015-06-24" version="1">MTINGGISFWYASDASPHQPPRAPLTTDATADVVIVGGGYTGLWTAYYLKRTAPDLRVTVLEQKFCGYGASGRNGGWLYNGIAGRDRYARLHGHQAAQRLQHAMNDTVTEVIDVAAAESIDADIHRGGVLEVARTPAQLARLKAFHTAELTFGETDRELYGATATRNRIDIADAVGSSWTPHGARIHPLKLLRGLATACERLGVVIHESTPVTELAPRRAVTPYGTVRAPYVLRCTEGFTASLKGQKRTWLPMNSSMIVTAPLPPSVWSQLNWADAPLLGDMAHAYMYAQRTADDRIAIGGRGVPYRFGSRTDNDGHTQPATISALRELLFSFFPVLTGTEITHAWSGVLGVPRDWCATVTLDATTGLGWAGGYVGSGVATANLAARTLRDLVLGESTDLTALPWVHHRVRRWEPEPFRWLGVHALYAAYREADRHETRTHTPKTTPLARLANHISGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZX3</accession>
    <name>A0A0F4IZX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000878">
        <property type="protein sequence ID" value="KJY27018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950504.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000878.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5473"/>
    <dbReference type="EnsemblBacteria" id="KJY27018">
        <property type="protein sequence ID" value="KJY27018"/>
        <property type="gene ID" value="VR44_28600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2049"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="44140" checksum="E55CE35A61A09C2C" modified="2015-06-24" version="1">MSTSTVSATSAAPKKGGGRRKLTLPWILLIIAAGLALVSVVRLISGANDLTSVGQFSGALQLAVPIALAGLGGLWAERSGVVNIGLEGMMILGTWFGAWAGYQWGPWTGVVLGIIGGALGGLLHAIITVTFNVNHIVSGVAINILAVGFTQYLSNFTFDKTPGGSSKQSPRIEPITEITVPGLSDWLATLQGKHWFLISDAAGALGGLVTNLSLLTVVAVLLVPATWWVLWRTAFGLRLRSCGENPVAAESLGVNVYKYKYIAVIVSGAMAGLGGAFLAIVSTGIYQEGQTGGRGYIGLAAMIFGNWMPGGMALGSGLFGFTYSLRLRGGAENVHAMLLLIAILLVLAVAWQLYKKKYLQAGIAAVCSAGLFVWYALTDQVPSQFVDAAPYVTTLLVLALSAQRLRMPKADGMPYRKGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J013</accession>
    <name>A0A0F4J013_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000961">
        <property type="protein sequence ID" value="KJY26266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950852.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000961.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26266">
        <property type="protein sequence ID" value="KJY26266"/>
        <property type="gene ID" value="VR44_30510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2517"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="295"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="45638" checksum="F9CCB9BBA892FF4B" modified="2015-06-24" version="1">MNPVNPMDAKHSGPAAGPPRGPSRPEFWRSPLRGPWLTAVFGIVLLFGITVVFVTGLLSYAAYEPDLAAVNDQTPGKGWLGFYLFSWPTSPYWLYRVTQGVHVTLGVVLVPVLLAKLWSVIPKLFAWPPVRSAAQAAERISLLLLVGGAGFEFATGILNTQLHYIFPGSFYTLHFYGAWVFIGAFAVHVALRLGRAVRALRAGPRQPDPDSEEAAGLVSPRPAAPTISRRGALGMVGLGSLALLAVTAGQSVGGWFRRTALLAPHGQEPGSGPNGFQINKTAASVGIRPSDIGPAWRLTVRGGGRQIDLTHAQLLALPQHEALLPIACVEGWSTADQHWSGVRLADLAALVGLGTHPPQVLVQSVQRGGSFSSVVLSAGQVRDARSLLAVRVNGALLSPDHGHPARVIVPGAPGVHNTKWVTRLTFGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0P9</accession>
    <name>A0A0F4J0P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950137.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27857">
        <property type="protein sequence ID" value="KJY27857"/>
        <property type="gene ID" value="VR44_26590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1443"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470016" evidence="2">
        <location>
            <begin position="37"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="495" mass="52793" checksum="0E3FD2E1A0AB31BA" modified="2015-06-24" version="1">MTLLHTVRVRHRSLGAALAAAGLLTTLLAAAGPAAASPDPGDSSPGAGSRQSADRAPGRELAPGEIPGQDEIVHSANVKPLANIPDAGLKGINSDLAFQGDYAYAGNYDGFTIYDIADPKAPKIVTQVLCPGGQNDVSVSGDLLFLSTDSSRNDDSCNSVSQPATEKSSWEGIKIFDIKDKKNPKYIKSVETACGSHTHTLVPGGRDIYLYVSSYSPSEAFPDCQPPHDGISVVKVPRKAPTQAAVVGFPVLFPDGGNPGAPTNPGVSKTTGCHDITVLPSEDLAAGACMGDGILFDISEPEHPRVIDRVQDNVNFAFWHSATFNEDADKVVFTDELGGGGAATCNEATGPNRGADGIYDITGTGDQRKLVFRGYFKIPRHQADTENCVAHNGSLVPVGDGRDIMVQAWYQGGVSVWDFTDSAQPKEIGYFERGPLTTDRLGLGGSWSAYYYNGHIYSNDIVKGLDVLRLDDRRTDSAKRVRMDRLNVQTQPEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Y5</accession>
    <name>A0A0F4J0Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950116.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000784.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27922">
        <property type="protein sequence ID" value="KJY27922"/>
        <property type="gene ID" value="VR44_26450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1474"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24002" checksum="5861B19812BD9C0C" modified="2015-06-24" version="1">MDVSVCRRLTVLLLVLTWVTGLIEAVSLLALGPVFTAMQTGNVLFLSFGLAHQGHLPALAAGVSLLSFAVGAVCAARLEGAAEARGRHWFVLGLSVEAALITVAAAIGWGLAPRYGSPAVRHLLTASALAVAMGFRNVTSMRVNLPGVPTTLVTRSMTALLGGSALGHDTAFGYGTGAWGRRAWAVAAMFTGGLTGGLLVRAGCPVNWLLLPAALVVLAVALVYLRQPALHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2I2</accession>
    <name>A0A0F4J2I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950457.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000866.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1133"/>
    <dbReference type="EnsemblBacteria" id="KJY27141">
        <property type="protein sequence ID" value="KJY27141"/>
        <property type="gene ID" value="VR44_28345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1993"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="53"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="42446" checksum="5FBB5AE885288834" modified="2015-06-24" version="1">MSTTGTTATTASNTAAVTTTVDVDRSDADYRAWLKEAVRKVQADANRSADTHLLRFPLPEAWGIDLYLKDESTHPTGSLKHRLARSLFLYALCNGWIRPGRPVIEASSGSTAVSEAYFAKLIGVPFIAVMPRTTSPEKCRLIEFHGGECHFVDDSMKMYEESADLAARTGGHYMDQFTYAERATDWRGNNNIAESMYQQLRLERYPEPAWIVATAGTGGTSATIARYVHYMQHDTRICVPDPENSCFFDGWTHHDPHASSDCGSRIEGIGRPRMEPSFVPGAIDRMMKVPDAASVAACRALEQAIGRKAGGSTGTGLWSALKIVSEMVAEGRKGSVVTLLCDPGDRYLDKYYSDEWLAAQGLDIDPYAKTIRTLLETGEWREPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J335</accession>
    <name>A0A0F4J335_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stilbene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000763">
        <property type="protein sequence ID" value="KJY28108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950034.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000763.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28108">
        <property type="protein sequence ID" value="KJY28108"/>
        <property type="gene ID" value="VR44_26035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1360"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="71"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="218"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="36353" checksum="818DB1157A48B750" modified="2015-06-24" version="1">MTRVLSVRSVFPPHRYPQAQITEALVRCLPPGADAALLRRVHASARVGHRHLALPLERYGPDSDFGTTNALFLRTALELGAEAVGGALAGAGLAAPEIGLVLSTTVTGLATPSLEARLVSRTGLRPGVRRVPLFGLGCAAGAAGLGMLHEQLAGRPGQAALLLSTELCSLTLQPTDTSMANLVAGALFGDGCGALVAVGAEHPRHDGAGGGGPWVVDARGRLYPGTEHLLGWDIGHWGLRMVLGRELPGLVGLHVAEEVESFLAGHDLKPADIDVWICHPGGPKLLDVLAGSLGLPGHALAASRRSLASVGNLSSASVLHILGAVQAAGPPAPGSTGLMLAFGPGFASELVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J348</accession>
    <name>A0A0F4J348_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949966.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28289">
        <property type="protein sequence ID" value="KJY28289"/>
        <property type="gene ID" value="VR44_25675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1234"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="453" mass="49024" checksum="ADCE7F5346AC1212" modified="2015-06-24" version="1">MVSVSELKQADPGKWRAAADDAVAVAKQCDGLATHAREDVARTVNRCWVGESGRAATERFVKHADDYETSAVALRAMAKVYDDLADAITAAQRDLNSALDYARTHDLKVEESGRVQLSHPVMAPPGSTEHLEPANHAQGIIVEALRQAAQADTEAARALRTIEGLTAISDPKLAKEALTPGSPLAIALALSGGVDGLHPINVSPAQFAAVNRASAETGISRKLLLAILWQEQQWYQNFSPGLTGPLPVGGRVFDWTLQQTIKPDKSLGITHMKPETARDVMHRNQTAFTLPDGTFLGDLGDAELTKYIEENPNEDIRLSAYHLSDLERNRYGARTDKQLFTLYAADTPEVRELNERYGDESSSRGGDIRTRGEHWDKVEPHLDDAMAWYALTDEQRATAMRQLESQTPAGHHVSIDPIYHEGGGPSTGTGTGPAEPGTPSPGPGPAPQPPRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3P2</accession>
    <name>A0A0F4J3P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949946.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28333">
        <property type="protein sequence ID" value="KJY28333"/>
        <property type="gene ID" value="VR44_25585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1216"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19734" checksum="860E8F219E05ECEC" modified="2015-06-24" version="1">MPYSTSTSTYLGEGPRVGLRPVRPADGPEFTARVRESRELHRPWLFPPDTLEAYEPYAAALAEGRLRAGFLVCELAGGAIAGFINVNNIVRGAFQCGALGYGAFAHAAGRGLLGEGLDLLLAHAFADTGLGLHRLEANVQPGNAASIALVRGRGFRLEGFSPDFLHVAGAWRDHERWAITAPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4H5</accession>
    <name>A0A0F4J4H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">VR44_24665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949779.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2989"/>
    <dbReference type="EnsemblBacteria" id="KJY28729">
        <property type="protein sequence ID" value="KJY28729"/>
        <property type="gene ID" value="VR44_24665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.929"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="499" mass="52287" checksum="CFEEDAC613A21716" modified="2015-06-24" version="1">MADTNIIKLTAAQTAEKIASGELTAVEVTEAHLARIDATDEKVHAFLHVDREGALAQARAVDAKRAAGEKLGPLAGVPLALKDIFTTVGVPTTVGSKILEGWIPPYDATLTRKLKEADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTKIPGGSGGGSAAALAAFQAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEVIAGHDPLDSTSIDAPVPPVVEAARNGSVAGMRVGVVKQFRGEGYQAGVVQRFDESVELLKELGAEIVELDCPSFDLAMAAYYLIAPSECSSNLARFDAMRYGLRVGDDGTKSAEEVTALTREAGFGDEVKRRIILGTYALSSGYYDAYYGSAQKVRTLISKDFEKSFEQVDVIVSPTTPTTAFAIGERTDDPLAMYLADLCTIPTNLAGNSAMSLPCGLAPEDGLPVGLQIIAPAMKDDRLYKVGAAVEAAFVERWGHPLLEEAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5A8</accession>
    <name>A0A0F4J5A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000692">
        <property type="protein sequence ID" value="KJY28938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949676.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000692.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28938">
        <property type="protein sequence ID" value="KJY28938"/>
        <property type="gene ID" value="VR44_24110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.816"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="19774" checksum="E7343221371DBBB1" modified="2015-06-24" version="1">MSDHDRTFRTAVTVGVSLDGFIARPDGDIDWLTSRGEQAGDTGYEAFMAGIDTLAMGRNTYEKVLTFGFWPYEGKRVAVLSGTLATDDPRVTVLPSLGALLAWLTAEGAENVYVDGGRIVQTFLREGLLDELTVTTAPVLIGEGIPLFGGLAGRDIELTLRSAKALDGGFTQATYAVTAAAPSVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5I1</accession>
    <name>A0A0F4J5I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000629">
        <property type="protein sequence ID" value="KJY29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949375.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000629.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29617">
        <property type="protein sequence ID" value="KJY29617"/>
        <property type="gene ID" value="VR44_22460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.381"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="41210" checksum="C9479C91C7836A79" modified="2015-06-24" version="1">MTTAPTRPAPALAAADALNARLGATRTEPAANPQLEALALAVTANQPVLLWGEPGIGKSAGMERLADALGVRLETVIASVHEPSDFAGLPIVGDDPATTGVPMAPPDWAVRLARTGHGLLFFDELSSAPPAVQAALLRVVLERRVGSLELPASVRIVAAANPPSSAADGWHLSPPLANRFVHLDWTHDARTVARGMAGTWPETALPAVDPARASGAAARARGVISGFLTARPGLVHHMPNDAEGRGRAWPSPRTWEMALRLLATGYASGAGREALSAALTGAVGDGAGLELLAYLENLDLPDPEKVLADPDAFALPKRGDRQLAFLIAVVAAVQGEPTRRRWEAGWAVLAKAVDAGVPDVAARAAADLAAMRDLSWTGGGGIDAFVELLQLAGALPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5J1</accession>
    <name>A0A0F4J5J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949453.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29455">
        <property type="protein sequence ID" value="KJY29455"/>
        <property type="gene ID" value="VR44_22880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.510"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="40626" checksum="2646BC054BE2537F" modified="2015-06-24" version="1">MCAAVALLALLYKARVLRTDRSAAQLALIGSFFFLVVIFTVSTPAVWVAVSRAVGIENFSGLLSQSAVIALSVCQQLVLLSLTRSPATARRAAVPRIVLLGVVLAAMVVLFFEAAAHGESPDDFAVVRAHYTPAYLAVYLAAFTLTQIGVGVMGWRYCRIAPSPWLRRGLRLVALSLPFSLCYSVSRLAGIVAAQFGGTGHAWEPAAQIGVAMAVCTQTVGWILPDWGPHLTAAADRIRYRRAHRILMPLHRTLTAQVPGPVIPMGRGADLRTRLYRTLIEIRDAQWELRTWMDEDVAGAARREAGRAGLGGEQTAAVVEAAQLRAALAAKARDEPPARPAATPLAACPPELAAELLHQQRVARALASPVVDRAVAGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5M2</accession>
    <name>A0A0F4J5M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5937 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000680">
        <property type="protein sequence ID" value="KJY29063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29063">
        <property type="protein sequence ID" value="KJY29063"/>
        <property type="gene ID" value="VR44_23830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5937" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6627" checksum="BD2F14765CBAD3A6" modified="2015-06-24" version="1" fragment="single">MTLRIDIAAMPSEGLRFAASPLAELTAMLHVLAEPEHHPEFGAWAADVWAGPCGRGCGRGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5W5</accession>
    <name>A0A0F4J5W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000668">
        <property type="protein sequence ID" value="KJY29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949585.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000668.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29158">
        <property type="protein sequence ID" value="KJY29158"/>
        <property type="gene ID" value="VR44_23615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.668"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035172">
        <property type="entry name" value="DUF5302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17227">
        <property type="entry name" value="DUF5302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6657" checksum="B3EEFAD8837A86C9" modified="2015-06-24" version="1">MTDTPDNHAADAEGKDKFREALERKARNARSQQAHHEGRLKIKGASGPNGQSRTFRRKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Y1</accession>
    <name>A0A0F4J5Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949944.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28331">
        <property type="protein sequence ID" value="KJY28331"/>
        <property type="gene ID" value="VR44_25565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="29552" checksum="7AAED63332BE4206" modified="2015-06-24" version="1">MKILISADMEGATGVTWPADVLPGTPQWERCRGMFTSDVNAAVLGFYEGGADQVLINEAHWTMRNLLLEELDARAEMITGRHKSLSMVEGVQHGDVDGVAFVGYHTGAGAEGVLAHTYLANSLTGVWLDGLRASEGVLNAHVVAEYGVPVILVTGDDLTCVDAAGYAPDARTVAVKDHVSRYAAVCRTPARTAADIRAAAKEAVKLAVRHEPVRGGPHTMEVEFDAEHLSMAATVVPGVERTGERRIAYTSGTMYEGIRTFKAVTTVVSAALEEQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J637</accession>
    <name>A0A0F4J637_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000662">
        <property type="protein sequence ID" value="KJY29228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29228">
        <property type="protein sequence ID" value="KJY29228"/>
        <property type="gene ID" value="VR44_23460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.634"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470761" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="11238" checksum="D910B68C778CF8E8" modified="2015-06-24" version="1">MARAFPGAVFFAAAVLAGAFPSTAFFATAVFFPAAASFTATAFFAGAVFFTAAAFFAGAAFFTAAAFFAGAAFLAGAARSAAAVEPGTAATSRVAVFFATMAAAPFHRMWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J718</accession>
    <name>A0A0F4J718_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gatB</name>
        <name evidence="13" type="ORF">VR44_24675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2987"/>
    <dbReference type="EnsemblBacteria" id="KJY28736">
        <property type="protein sequence ID" value="KJY28736"/>
        <property type="gene ID" value="VR44_24675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.931"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="332"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY28736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="484" mass="52140" checksum="2C4D2AD337A00D49" modified="2015-06-24" version="1">MGLEVHVELGTKTKMFCGCSTELGAEPNSQTCPTCLGLPGSLPVVNAIGVESAVKIGLALNCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGEIFRVEIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERAPEVAKAYVAELREVIKALGVSEARMDKGQMRCDVNLSLRPNGTKEFGTRSETKNVNSLRSVERAARFEIQRHAAVLSSGGSIVQETRHFHEEDGSTTAGRIKDNAEDYRYFPEPDLVPVAPARAWVEELRAALPEMPRLRRNRLREEWGVSEHDMQSILNAGAVDSIVATIEEGADSAAARKWWMGELARNANEQGVSVDELPITPAQVARIAALVAAGDLNDKLARQVIEGVLAGEGTPDEVVEKRGLKVVSDEGALGAAVDEAIAGNAAIADKIRGGKIAAVGALVGAVMKTTRGQADAARVKELILEKLGVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7L8</accession>
    <name>A0A0F4J7L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_24200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949694.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28921">
        <property type="protein sequence ID" value="KJY28921"/>
        <property type="gene ID" value="VR44_24200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.792"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="145"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="33441" checksum="0D83A9EC70DD5B15" modified="2015-06-24" version="1">MTNLVLLTLGATLLAGLFVSLGVHAYSAGLAQRAALIERLAAEGAPEAPGRRRRFAGLDRRLRRTKLGRRIEVKLATTGLDLTPGEFFAYMLMAVAGVWLVSAALLAPFFGPVAGLIGLWAANAFLNWQRARRTERFINQLPELARILANATQAGLALRTAIGIAAEELEAPAGEELSRVADRLAVGHSIEEALGEIVERLPSRELVVLVSTLVLSARAGGAIVGSLRNLVVTLEQRKETRREIRTQLSQVTVTAYLVPAIGLGSLLLVDMMMPGALDRMTGALIGQTAVLIALGLFTLGFVLIRRLSKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7P3</accession>
    <name>A0A0F4J7P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949289.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29814">
        <property type="protein sequence ID" value="KJY29814"/>
        <property type="gene ID" value="VR44_22015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.283"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="22290" checksum="335D728CA7B9534F" modified="2015-06-24" version="1">MSGPRPSAGGRLLTFTAWSVLVLGLWLWGKEITGVPAGPLSGRAGGQAAPGLPAARAPLTAAMPARVDVPSLGVQAPVIARGLDRQGAIEPPPYELPGTVGWWGAGPAPGAAGAALMVGHVDTKSKPAVFFGLGSVKPGAKIRVARADGTVAEFTVEDVRVYERAGFDPHKAYGPRVEGRSELRLVTCGGTYDKAAGQYSANVVVSAYLTGAGARPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Y6</accession>
    <name>A0A0F4J7Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29046">
        <property type="protein sequence ID" value="KJY29046"/>
        <property type="gene ID" value="VR44_23860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.745"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="47" mass="4860" checksum="3FE2A1256FB00246" modified="2015-06-24" version="1" fragment="single">MLLAEVARVSREVAETSARSRKAALLAELFAAAPADEAGLVIAYLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J840</accession>
    <name>A0A0F4J840_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000556">
        <property type="protein sequence ID" value="KJY30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948950.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000556.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30552">
        <property type="protein sequence ID" value="KJY30552"/>
        <property type="gene ID" value="VR44_20185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8742"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14954" checksum="F2D0847C8943C007" modified="2015-06-24" version="1">MPDTTPTPPPPREPVGPPSPETHVIDYRAAEQLLEARDPRGAVRLLDSVIAAHPENTAARLLRARAFFAAAQLRPAQLEFELVLEREPDNAFAHFALARTHQRSGRHEQARRHFRLAAALDPQPEYLAAARFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J867</accession>
    <name>A0A0F4J867_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_21580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949210.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000603.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2202"/>
    <dbReference type="EnsemblBacteria" id="KJY29933">
        <property type="protein sequence ID" value="KJY29933"/>
        <property type="gene ID" value="VR44_21580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.194"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="172"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="43731" checksum="8B83067D3A7C8A11" modified="2015-06-24" version="1">MAGKKNPNGAGSIWQRKDGRYEARVYVPQPDGTRARKTVYGKTWQECDEKRQELVLRDRQGVPTPTRSARLSEWLPYWLEQHVEPRRKLSTYDKYETHVRLHLVPLLGARSLESLSTADVRRFLTRVQKDKTVATAKEAHRVLRTALSGAVRDELITRNVASLVEPPRAKQREIRPWTLEETLAFLEAARGEALYAAFVLAIAMGLRRGELVGLRWSDLDLDKRVLHVRQQTQRRRGQLYQDDPKSRRQRAVPLPAMCIAPLRWHRLKQRAIFRETGVEWSEAGPVFATRNGRTVEPRNVYRAFTRVAADAGLRVVRLHDARHGCATLLTAAGVAPRVIMEILGHSQISITMDVYTHVVDDTKREAISHMDRMLRRQRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8S4</accession>
    <name>A0A0F4J8S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000537">
        <property type="protein sequence ID" value="KJY30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30787">
        <property type="protein sequence ID" value="KJY30787"/>
        <property type="gene ID" value="VR44_19525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6208" checksum="76AC40B64EDBD64A" modified="2015-06-24" version="1">MRQHSGAHSDNAALTASAASTLTIPAARRRPADGRQRGTDSPDEGPAGARPDSSSVESPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J954</accession>
    <name>A0A0F4J954_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000571">
        <property type="protein sequence ID" value="KJY30344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000571.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30344">
        <property type="protein sequence ID" value="KJY30344"/>
        <property type="gene ID" value="VR44_20700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8855"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="144"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="37793" checksum="462FD61E6F1DDEC1" modified="2015-06-24" version="1">MIPTVVWGTGNVGRAAIRAVEAHPALELTAVIVHNPAKIGRDAGELAGLDRRLGVAATDDIGAVLAARPAAVVYAASGDVRPDDALADITRAITAGAAVVSPALYTLYDHRSAPPEFRDPVLAAIAEGGGSLFASGVDPGWGNDVLPLLLSGLGTTVDAIRCQEIFDYSTYDQPDSVRDLVGMGRPMDEEPMMLMPSVPTMVWGGQIRMMARALGVELDEIRETSDRRALDTTVTTPTMGEFQAGTQGAIRFEVQGIVAGEPRIVIEHVTRIHASCAPDWPAPPDGGAGAHRVVIEGRPRIEVTVEATDEGENRSAGGNATAVGRLVGAIDWLVEAEPGLYDALDVPLRPAVGKLGRKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAA1</accession>
    <name>A0A0F4JAA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000606">
        <property type="protein sequence ID" value="KJY29901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29901">
        <property type="protein sequence ID" value="KJY29901"/>
        <property type="gene ID" value="VR44_21690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.217"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6440" checksum="1FBF1ACA179F1426" modified="2015-06-24" version="1" fragment="single">GKGDDISNIDQKALDINVDVIANAVGHYAYDLAPLSQPVVSKPTTGSGNGGGLRPGHDHESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAJ2</accession>
    <name>A0A0F4JAJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31392">
        <property type="protein sequence ID" value="KJY31392"/>
        <property type="gene ID" value="VR44_18235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8194"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470527" evidence="2">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="18133" checksum="7E14350C723F10AA" modified="2015-06-24" version="1">MSLTYLPRAAAAATAVAALFALATGCSGAGAPPAAEDPGPAAAAPVSLPAPRSAPSPAAVLTPAPAAGEVRTEQGPFTDRVKLTNTRLTTAGTPSVTGHVAISSDVSDTLALEITAAYYDAQGRLLGTGTFQYQEEGEDAHAQEHHDGPRAAGDGIDFTVPADHLTGTPAAAVLSVPVLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAN3</accession>
    <name>A0A0F4JAN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948799.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000530.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30869">
        <property type="protein sequence ID" value="KJY30869"/>
        <property type="gene ID" value="VR44_19345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8476"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="42996" checksum="BE2BA8CBCCCA7999" modified="2015-06-24" version="1">MKGPDYYIPAAAMAISLVCKLPALRTNWRDPLLRSVCFLLLLAGAVFTFAAPPTIEAVNRWTGIPNFSAPLVYCLMTAFSASCLVLVFNWRGGPAEEIRHTSLRWIAGYSVVISAIVVLFALGSAPVERLVDFDTYYANTPYIRLMIASYLLAHNVAVMMMVSMCWRWSLQVCGWLRAGLLIIVSGYAISLAYDAAKMSAVAARWLGHDLDFLSTLVAPPLASAGALVSSVGFVLPLLYQRVSDSWRTWSTYRNLGALWQEVQSTAPSGTPGVRMSWWSPAEIRVIQRESDIHDGFLRLGPCFDRRHRDTAYERALAAGADEETARAVADAAMVAAAVTVCAAHPEAAGSEEDQAEENRVLLTADGPRDLVRISHALRHSPLVAAARRQAAPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBH3</accession>
    <name>A0A0F4JBH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949056.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000572.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30336">
        <property type="protein sequence ID" value="KJY30336"/>
        <property type="gene ID" value="VR44_20750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8868"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24666" checksum="03CBE9B6BB36D947" modified="2015-06-24" version="1">MSAPVRVLVVEDDPVAADAHALYVGRVPGFTAVAAVHTLAEATRVLERTPVDLLLLDLTLPDGNGLRFARALRASGHPADVIAVTSARDLAVVRESVSLGVVQYVLKPFAFPTLRERLLRYAEFRAAAGEAVGQDDVDRALAALRAPAAAQLPKGLSAPTLDRVAALLREAAEGLTAAGAAGAAGISRITARRYLEHLVDTGRADRAPRYGQVGRPELHYRWRAAEAGSVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCT5</accession>
    <name>A0A0F4JCT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000479">
        <property type="protein sequence ID" value="KJY31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948492.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000479.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31624">
        <property type="protein sequence ID" value="KJY31624"/>
        <property type="gene ID" value="VR44_17750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20087" checksum="FA9BF4FBF57742A8" modified="2015-06-24" version="1">MTRTLYVISCAAPPARHVTTGIKAAQARGWDVALVLTPAAHRWSVEEAGGDSELDAWRALTGHPVRHTYKLPSQSDVLPDPDALLVAPATLNTTTKWAAGHADTLALGLITEALGMPHRPVVALPYINAAQAQHPALAPAIATLRGAGVRYLLDDGTGPGFRPHPPKHGNVDAYPWDLALDTLDEPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDB6</accession>
    <name>A0A0F4JDB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31809">
        <property type="protein sequence ID" value="KJY31809"/>
        <property type="gene ID" value="VR44_17455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8028"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="414" mass="43399" checksum="D1B6025F219FD912" modified="2015-06-24" version="1" fragment="single">EAEAEADVDPLPVPPAPEVPSPAAAAGSGEAPPPVRPDPAAVIPWGVRVAAEASWRLLLLAGMVWVLMKVISEVRLVVLAFAAALLVTALLQPFVVRLRRIGLPRGLATAVTAVLGFVVIGLVGWFVVWQVMENLDDLSNRLREGINELKSWALDSPFHVTEKQINDIAKNLSETIGTNTEEITSAGLQGVTVLVEVLTGMLLSMFSTLFLLYDGQKIWNWVLGLVPSAARPGVAGAGPRAWRTLTAYVRGTVLVALIDAVFIGLGLYFLKVPMAVPLAVFIFLFAFIPLVGAVVSGALAVVVALVTQGPFTALMVLLVVLAVQQIEGHVLQPFILGRAVRVHPLAVVLSVAAGGMIAGIGGAVVAVPLVAVTNTVVVYLRAYSRERRLAPAAPTGPAPHGATAVGSAEREAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDE0</accession>
    <name>A0A0F4JDE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000469">
        <property type="protein sequence ID" value="KJY31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948457.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31763">
        <property type="protein sequence ID" value="KJY31763"/>
        <property type="gene ID" value="VR44_17565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8076"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="10634" checksum="F9BBA5A21F39E770" modified="2015-06-24" version="1">MKQQFILAGKLDELGDSLLGTLGGWSDKGLKVALTVVVVVTVARRVSLKAGIGALIAMVLALGLYEARESLSGAVKDEINHPAKGAGAVTLVVTPKPAAGGSGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDG7</accession>
    <name>A0A0F4JDG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948181.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32402">
        <property type="protein sequence ID" value="KJY32402"/>
        <property type="gene ID" value="VR44_16080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7637"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="14147" checksum="614C8B3648FDBD38" modified="2015-06-24" version="1">MKITSSAVSLNVDDVPASSAFLVEHFGFREEMAADGFASLTRDDAGMNVIFLRRGLESLPADQRDEHAAGLILAFVVEDLEGELARLRSEGVAITMPLTDEEWGERAFQVRDPNGVIVQLVDWNAPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE06</accession>
    <name>A0A0F4JE06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948338.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32034">
        <property type="protein sequence ID" value="KJY32034"/>
        <property type="gene ID" value="VR44_16915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7820"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="13613" checksum="C17BEF98FF068591" modified="2015-06-24" version="1">MAGSGVPVIGSVDELTELLHARHGGPRTPDRDLGLRTAALLRRSHPYDKELQVAGLVHGLGGLPGAEAAEAVRALLGDRVARLLRGRTAAGEDAEALRQAAEAGRTAGLDAGLVEDWRPVLELVAAGAYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF37</accession>
    <name>A0A0F4JF37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Indole acetimide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000482">
        <property type="protein sequence ID" value="KJY31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31586">
        <property type="protein sequence ID" value="KJY31586"/>
        <property type="gene ID" value="VR44_17825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="29199" checksum="181A27FCA24AD549" modified="2015-06-24" version="1" fragment="single">MPEALWQKTAAAQAEAVRGGEVSAAELVESHLERIAEVNPRVNAVTQLMAERARAAAELTDRRRAAGEELGPLAGVPFTVKETTPVEGVPTTFGVPRFRDLVARADAPPVARLRAAGAIPIGHANMPTLVLAGMHTRSELFGDTANPWDPARTPGGSSGGDAVAVATGMAALGLGNDSGGSIRVPAQFCGVAGLKPTTGRFPADHRVLGPEDPGPASQALVTDGPFARSVADLRLAYEALAGTDPRDPRAVPVPAYGPPLTGPVKVAVVADPGGRGVHPSVRAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFD5</accession>
    <name>A0A0F4JFD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_15820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000408">
        <property type="protein sequence ID" value="KJY32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948131.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000408.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32509">
        <property type="protein sequence ID" value="KJY32509"/>
        <property type="gene ID" value="VR44_15820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7572"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23717" checksum="B75923C520748D73" modified="2015-06-24" version="1">MSPRNSPKIDKGQAVETSLRLLNEVGLDGLSLRAIAKELGVQAPALYWHFKNKQELLDEMATEMYRRMTADSPLSPGLSWQDRLLTANRGLRTALLRYRDGAKVFSGSRFTGTEHAVAMEDNLRALTEAGFTLPQAVRATTTAYLFTLGFVTEEQGVEPLPGERREGFDVAERAARFAEFPLAAEAGADLFQNYDEGFEEGLALVVAGIANRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFR2</accession>
    <name>A0A0F4JFR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947919.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33030">
        <property type="protein sequence ID" value="KJY33030"/>
        <property type="gene ID" value="VR44_14655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="41584" checksum="88F96C4208D22FB5" modified="2015-06-24" version="1">MSTVHATAALLSEPALLRAHLRALAVLDGAIGDDPDSARYRYDAAWGPGEEAALMENGSGDEFSVLFTPAGVLIRGFDHESEMSPYGTDDEQVWPGVVDDVPSALRPLLDEPAFYDEGLATPRVTACLWRETGDTAWRTGPDIGFPPGSPDPDGSGHLFRLLTDRSPEAVQAHFEDYYERPVPLEAVRHVLAGHPLTPETARALNPAALSDEALLRRIAAHPEVDAYLACDGEFDLTRTDPIESIALPAGLPVEPVAGCGAGGTHYLCGPDGPDSARPVLYTDSEGQATLIAESLAEALTLAVVLPSWHDALAGFRPPALNADYMEDNPDHPEVRDRLLAALRLPPASESEVLARLLTTAARTVPDGFLPTVEGEEDAAFEPMLRLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFR7</accession>
    <name>A0A0F4JFR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">VR44_14685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947924.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5612"/>
    <dbReference type="EnsemblBacteria" id="KJY33035">
        <property type="protein sequence ID" value="KJY33035"/>
        <property type="gene ID" value="VR44_14685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7264"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="35675" checksum="32C01414433D5373" modified="2015-06-24" version="1">MTAPAPASRRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPVYVRHEIVHNKYVVQTLQKKGAIFVEKTEEVPPGNIVMFSAHGVAPVVHEEAARGRLATIDATCPLVTKVHKEAIRYANEDFDILLIGHEGHEEVIGTSGEAPDHITIVDGPDDVAKVEVRDESKVVWLSQTTLSVDETMETVDALKQKFPLLVSPPSDDICYATSNRQAAVKAMGAEADLVVVVGSKNSSNSIRLVEVALDAGARAAHLVDFASEIDEAWLEGVTTVGLTSGASVPEVLVEEVLEWLAQRGFADVEIVKTAEESIVFSLPKELRRDLRTEAAELVAGGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFY8</accession>
    <name>A0A0F4JFY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000368">
        <property type="protein sequence ID" value="KJY33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33257">
        <property type="protein sequence ID" value="KJY33257"/>
        <property type="gene ID" value="VR44_14290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7205"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25224" checksum="F9AEE02B0F79A59C" modified="2015-06-24" version="1">MWTRDQQECGTGAPAARTVAPDGDVILLVPGESAAARAAAHAQDDDLPAVIEITDVAPVSVPHRIRGRARLAGWLTPVRGDDRAPCAALMAERHPVGELLGLTESLDALHPGRPAWMLLRLEVGEVSVDDLWGAERVDPEELAAAGPDPMTAHEAELLQHLASVHPDRLAGLCGLLGSREAAGLTPVPLALDRLGLRVRFTRGPGLAAFDARFDFPEPVTDVCGLRRALRSLFAAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGX2</accession>
    <name>A0A0F4JGX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947743.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33602">
        <property type="protein sequence ID" value="KJY33602"/>
        <property type="gene ID" value="VR44_13670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7010"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="52"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="38167" checksum="493C42DF3257926B" modified="2015-06-24" version="1">MSDDRAERIADFIRPLRVEPGSEVRLSRDFDPRYKAGLKKPEGVELLRSGVSLLAEYQERLAAQNTYGVVLCLQALDAGGKDGTIRHVMSGVNPQGVRVSSFKVPSVEELGHDYLWRYAQRLPSRGEIAIFNRSHYEEVLVVRVHPAILDRQNLPEGSYGPDLWDRRFREINHWERYLTDNGFKVVKIFLNLSKEEQRIRFLKRIDLPEKNWKFSAADVRERRYWDDYQRAFSAMLSATSTKWAPWYVVPADRKWFARICAAAVLAHTLMDIDPQFPDVGEEARKDLLVTRRALEKEAPAGSEADPYAAGHPEKKKGRSGRHKKGKKGRKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHK1</accession>
    <name>A0A0F4JHK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_13120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000334">
        <property type="protein sequence ID" value="KJY33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947643.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000334.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33832">
        <property type="protein sequence ID" value="KJY33832"/>
        <property type="gene ID" value="VR44_13120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6687"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="37165" checksum="0B50DB2053CD9A1D" modified="2015-06-24" version="1">MPVLTRLIPSPVVVDISRGAMDQLDGILADQRISTSGRLAIAISGGSGQALRARLEQALPHADWYPVVDGTIDSAVKLADDIKGRRYDAVVGLGGGKIIDVAKYAAARVGLPMVAIATNLSHDGICSPVSILDNDNGRGSYGVPTPIAMVIDLDVIREAPTRFVRAGIGDVISNISAIADWELSHKITGEAVDGLAAAMARTAGESVLRHPGGCGDDEFLTVLSEALVLSGIAMSISGDSRPSSGACHEISHAFDLLHPGRSALHGEQVGIGAAFAMHLRGAREQSGLFVEVLRRHGLPVLPQEIGFSVDEFTAAVEYAPQTRPGRFTILEHLNLSAAEIRDAYADYAQTIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHQ2</accession>
    <name>A0A0F4JHQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_14160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000365">
        <property type="protein sequence ID" value="KJY33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947833.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000365.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3368"/>
    <dbReference type="EnsemblBacteria" id="KJY33293">
        <property type="protein sequence ID" value="KJY33293"/>
        <property type="gene ID" value="VR44_14160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7178"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="6">
        <location>
            <begin position="50"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="243" mass="26501" checksum="164858F7AF5DFE8E" modified="2015-06-24" version="1" fragment="single">MYKLFFNLVFKRMDPEKAHYTAFRWIRLAARTPVLRTFVAAALAPRYEGLRTEALGLRMHGPFGLAAGFDKNAVAIDGMAMLGFDHVEIGTVTGQAQPGNPKKRLFRLVPDRALINRMGFNNEGSEAVAARLAARKPVFRTVVGVNIGKTKVVPEAEAAADYVISTERLARHADYLVVNVSSPNTPGLRNLQATESLRPLLTAVREAADRSVTGRRVPLLVKIAPDLADEDVDAVADLALELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI23</accession>
    <name>A0A0F4JI23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pimeloyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948112.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7306"/>
    <dbReference type="EnsemblBacteria" id="KJY32611">
        <property type="protein sequence ID" value="KJY32611"/>
        <property type="gene ID" value="VR44_15715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7546"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="537"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="744" mass="78885" checksum="6E544FDBFC1C09EB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIC1</accession>
    <name>A0A0F4JIC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-ACP desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_12910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000325">
        <property type="protein sequence ID" value="KJY33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947603.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000325.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3559"/>
    <dbReference type="EnsemblBacteria" id="KJY33935">
        <property type="protein sequence ID" value="KJY33935"/>
        <property type="gene ID" value="VR44_12910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6699"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="36550" checksum="14B651A20EA89965" modified="2015-06-24" version="1">MTITSPHLGSSEAWTDAKLLYALEEVVEKELNRHLKVTKDWMPHEYVPWSDGRNFPGFFEDGEAWDPQQSKVTDIGKIALVVNLLTEDNLPSYHHEIATLFGRNGAWGTWVHRWTAEEGRHGIVMRDYLLASRAVDPDKLEAFRMQHMSEGFESDNSHSMLHSVAYVAFQELATRISHRNTGHQSGDPVCDRMLARIAQDENLHMIFYRNLLAAAFELAPDLTMQAVRDVVVNFRMPGHGMPGFERMAAQMAIGGVYNLRIHHDDVLSPVIRFLKIMDIDGLGPEGQKAQEELGLFMNGLDSEARKFDERLAARAARMAARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJE0</accession>
    <name>A0A0F4JJE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000298">
        <property type="protein sequence ID" value="KJY34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947462.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34320">
        <property type="protein sequence ID" value="KJY34320"/>
        <property type="gene ID" value="VR44_12110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6509"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="35820" checksum="766772767699EA50" modified="2015-06-24" version="1">MLVEGRGPLSRAVVAALRGGPPPAPDTAAARGADPWGEDLHLALYLLYELHYRGFEGVDDALEWDPALLAVRGTLEDRFLHALRTATAGAPQTVAEAFAALLVEPVDLSGSLSHHLETEGELWQLREYAALRSLYHLKEADPHAWVIPRLYGRAKAAMVAIEYDEFGAGHPDRIHARLFAGLMADLGLDTAYGHYLDRAPAPLLATVNLMSLLGLHRALRGALVGHFAYVEVTSPPGSRRLARAMRRCGAGPAAEHFYAEHVEADAVHEQVVRHEVVGGLLADEPELESDVAFGCAATVLLEERLAAHIRTAWDRHRSALRTPAGAGPAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJG7</accession>
    <name>A0A0F4JJG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger CDGSH type superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_12925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000325">
        <property type="protein sequence ID" value="KJY33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000325.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33939">
        <property type="protein sequence ID" value="KJY33939"/>
        <property type="gene ID" value="VR44_12925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6702"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_19" evidence="3">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ZnF_CDGSH" evidence="4">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15569" checksum="65CA1C4D1FC6DBF1" modified="2015-06-24" version="1">MEANEPKEPKEPKEPKAYAGEGITVTYDAGRCLHAARCVGGLPEVFDTGRRPWIQPDGAAPERVAEVVRRCPSGALQYRTATGPAEEGDRPATVVRSPLGQLFLRGELSVTTASGEVRRETRAVLCACGVSGNQPYCDHSGSCGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLE9</accession>
    <name>A0A0F4JLE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000248">
        <property type="protein sequence ID" value="KJY35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947241.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000248.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35005">
        <property type="protein sequence ID" value="KJY35005"/>
        <property type="gene ID" value="VR44_10965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="3">
        <location>
            <begin position="6"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="498" mass="54548" checksum="6FA7CE448102DC9D" modified="2015-06-24" version="1" fragment="single">MSTPVWITATPPATHGELHVGHLAGPYVAADVLSRYLRAEGEPVLFTTGTADHNSSVHARALRAGRKPEEVAEGYRAAITSDWLRSGVEFDHVVRPRQDKGYGRWLADLFRRLHAEGVIAARTRLTPYCESCERWLHGAHVRGTCPHCAAPSDGGMCHECARPNDGGDLLEPRCAQCGSTAVPRRCRRLYVPLEPHRDALAEYWAGTGLPPRLAALCESLVEDGLPDIAVAHPAEWGLPVPVDGFPEHRIDGCFEAAAMHLFGYGDQALPERAIHFCGFGHAFCHAVLLPVLLFAQGVKLPQHFCVNEAYVVEDEALVWGSGQKAWALDLITEYGSDTLRRHVLQARPLGRRTEFRPERLAAARRELDESWNSWLSRLFAAVREECAGLAPAALPGGAGWEVLERRLLRGVEDLREAYSPESFDPRRAVALLDEMVRSAADFGHVNAHEAHRPTADSRHLPALAAQLAVARALGAWARPVMPEGADRLSAALKAQPXG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM32</accession>
    <name>A0A0F4JM32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35255">
        <property type="protein sequence ID" value="KJY35255"/>
        <property type="gene ID" value="VR44_10465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5836"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13387" checksum="B28F4DA3D9D7C2EC" modified="2015-06-24" version="1" fragment="single">GMLHAVNPVGVVAFVAASGLSIAMYFGLFGEGLQPYSPVAAAVIAFVLTPLTAVVTQGRYYLRRTDDGIDEPLLDGDGNPSAVTFDCHVCHQPYERPDLAACVAHEAVVCSLCLSTDKSGEHVLPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JME2</accession>
    <name>A0A0F4JME2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947531.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34116">
        <property type="protein sequence ID" value="KJY34116"/>
        <property type="gene ID" value="VR44_12515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6564"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="471" mass="52347" checksum="B8E5B103CD920623" modified="2015-06-24" version="1">MTIDTSPEAQLQEPPQQRSLSTAAARNLATTTKSAPQMQEITSRWLLRMLPWVETKGGTYRVNRRLSYTVGDGTIDFVQDGASVRVIPQELGELALLRGFDDVQVLTALADRCVQRDFRAGEVLVERGTPADQIHLIAHGRISQTSVGKYGDEVAVAVLADGERFGENALLDADATWDYTATADTPGTLLTLSRAEFSAVLAQAPHLQEHIRRFSSLPLQRQNRHGEAEIAMSAGHTGEAELPGAFVDYELNPREYELSVAQTVLRVHTRVADLYNGPHNQTEEQLRLTIEALRERQEHELINNREFGLLHNADFKQRIQTHSGPPTPDDLDELLCRRRGTRFLFAHPKTIAAIGREFNARGLYPDHVDLGGQQVPAWRGVPILPCNKIPITKENTSSILAMRPGEDNQGVIGLRQTGLPEEYEPGLSVRFMGIDERSIISYLVSTYYSAAILVPDALGVLENVQIARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNH1</accession>
    <name>A0A0F4JNH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947117.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35389">
        <property type="protein sequence ID" value="KJY35389"/>
        <property type="gene ID" value="VR44_10280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5924"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17076" checksum="D55E23D8B893E314" modified="2015-06-24" version="1">MTTTSPLQNGTATLGQRPIALVAWRATEAILRHSQATLARIDVTQPQWWALNNIVRAEDGLTRDEIRAVAVPYDMGAEVMVHAVDALVHRGWLGIGADGRLTCTQEGHEGLATAKEHMDRVRADILGDITEEEYAAAVSVLQRIADNLAPAAATSTVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPW9</accession>
    <name>A0A0F4JPW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947264.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34956">
        <property type="protein sequence ID" value="KJY34956"/>
        <property type="gene ID" value="VR44_11085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6101"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18668" checksum="97A9032E3A888838" modified="2015-06-24" version="1">MTPTLRTERLLLDPYLPDDEEAFVALFQDTRVSRWMGDGPVPEEEDRALFGRIFTKVYARGLFDVWAVRRDGELIGHAEIKRTDAVGGHEIIYALAPAAWGAGLGSELARALTAYGFDTLALAEVHATVAAENGASLALLERIGFEHVRDITEDDGSTTRVLTLRAARDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPY4</accession>
    <name>A0A0F4JPY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000162">
        <property type="protein sequence ID" value="KJY36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36417">
        <property type="protein sequence ID" value="KJY36417"/>
        <property type="gene ID" value="VR44_08090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="436" mass="47222" checksum="82DB00DE624B80FD" modified="2015-06-24" version="1" fragment="single">MSQLSQRPEKPAVGLPLPHESANLHVTGAALYTDDLIHRTKDVLHAHPVQVMKAHGRITALRTEPALAVPGVVRVLTAADVPGVNDAGMKHDEPLFPDTVMFHGHAVAWVLGETLEAARLGAAAVEVELDEQPSIVTLSEAIAAESFHGARPVMLAGDVDAGFADSVHVFTGEFQFSEQEHFYLETHAALAHIDEAGQVFVQSSTQHPSETQEIVAHVLGLHSHEVTVQCLRMGGGFGGKEMQPHGFAAVAALGAKLTGRPVRVRLNRTQDLTMSGKRHGFHAAWKIGFDAEGRIQALDATLTADGGWSLDLSEPVVARALCHIDNTYWIPHARVAGRIAKTHKVSNTAFRGFGGPQGMLVIEDIMGRCAPLLGLDPMELRERNFYRAGQHTPYGQPVTQPGRIRAVWDQVKENGGLADRRREIAAFNAAHPHTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ09</accession>
    <name>A0A0F4JQ09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ORF">VR44_08910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946860.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35919">
        <property type="protein sequence ID" value="KJY35919"/>
        <property type="gene ID" value="VR44_08910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4952"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="35746" checksum="EF090FAD3F4594ED" modified="2015-06-24" version="1">MTRELRAVEWAGDGLALIDQTALPHREVVLRVTDVDGLVDAVRRLVVRGAPAIGAAGAYGVAIALLQAEREGWDGSRIRAEVARIRAARPTAVNLAVSVDRVLARLDDGVTAVLAEAAAVQREDVEANHALGAHGADWLLKRQGEDRPLRVLTHCNTGALATAGWGTALGVIRELHARERLETVYADETRPLLQGARLTAWELAQEGIAHYVQADGAAAGTILRGEVDVAVVGADRIAANGDTANKVGTVGIALACAYAGIPFVVAAPTTTVDLATPHGDGITIELRDEAEVLEWAGVRTAPAGSRGHNPAFDVTPGGLVTALVTERGVLEVSAGELPGLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQB1</accession>
    <name>A0A0F4JQB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35121">
        <property type="protein sequence ID" value="KJY35121"/>
        <property type="gene ID" value="VR44_10855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6022"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="182"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="446"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="629" mass="67650" checksum="983388C9263D9D2E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQF3</accession>
    <name>A0A0F4JQF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000162">
        <property type="protein sequence ID" value="KJY36415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946707.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36415">
        <property type="protein sequence ID" value="KJY36415"/>
        <property type="gene ID" value="VR44_08095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4446"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012175">
        <property type="entry name" value="Xanth_DH_ssu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036557">
        <property type="entry name" value="XdhA_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="217"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="501" mass="52505" checksum="C5A6E54F81347222" modified="2015-06-24" version="1">MATSTPTPLITVNGKETPLAPAAPHTTVLDFLRERGLTGTKEGCAEGECGACSVLVARPGVDKPTDWVAVNACLVPAAALDGQEVITSEGLATPGEPGTPPALHPVQEEMAVRGGSQCGYCTPGFVCSMAAEYYRPDRCAHAAPPDGAGSGHGHPEHGDPEHGPNGFDLHALSGNLCRCTGYRPIRDAAFAVGTPAGDDPLALRREQSPPAPAATAYTRDDSTFLRPGSLAEALELLRERPGAVVVAGSTDWGVEVNIRSRRADCVIAIDRLPELRSLHVASDHIEIGAAQTLTEIERRLDGTVPLLAELFPQFASRLIRNSATLGGNLGTGSPIGDSPPVLLALEASVVLADADGEREVPLGDYFTGYRQSVRRPGELIRAVRIPLPLSPVTAFHKIAKRRFDDISSVAVAFALDIQDGIVRKARIGLGGVAATPLRALATEAALEGRAWTAETAEAAAEVLKAQGTPMDDHRASAAYRSAMLGQSLLKLYSQTTEAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQT7</accession>
    <name>A0A0F4JQT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000232">
        <property type="protein sequence ID" value="KJY35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947145.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35296">
        <property type="protein sequence ID" value="KJY35296"/>
        <property type="gene ID" value="VR44_10455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5833"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="512" mass="54627" checksum="CD5010DD93C2E449" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS82</accession>
    <name>A0A0F4JS82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_06190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000115">
        <property type="protein sequence ID" value="KJY37227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946352.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000115.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene85"/>
    <dbReference type="EnsemblBacteria" id="KJY37227">
        <property type="protein sequence ID" value="KJY37227"/>
        <property type="gene ID" value="VR44_06190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2991"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY37227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="42145" checksum="9334BBDC6424A027" modified="2015-06-24" version="1">MSASQTSDVPTLLVKIFGKDRPGITAGLMDTLAAYSVDVVDIEQVVTRGRIVLCVLVTKPATTAEGELRSTVHSWAESLKLSAEIISGTGDNRPRGVGRSHVTVLGHPLTAESTAVIASRITETGGNIDRIFRLAKYPVTAVEFAVSGAETEPLRTALATTAAQIGVDVAVVSAGLHRRAQRLVVMDVDSTLIQDEVIELFAAHAGCEAEVAEVTERAMRGELDFEQSLHARVALLAGLDESVVEKVRAEVRLTPGARTLVRTLKTLGYQVGVVSGGFTQVTDDLRERLGLDFAQANTLEIVDGKLTGKVTGEVVDRAGKARLLRRFAAEAGVPLAQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNVPFLDAVLYLLGITREEVEAADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTB9</accession>
    <name>A0A0F4JTB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_05410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37607">
        <property type="protein sequence ID" value="KJY37607"/>
        <property type="gene ID" value="VR44_05410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1718"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="407" mass="40919" checksum="3D7430C3D2548532" modified="2015-06-24" version="1">MPQAAGRPAAGPRPSGFWVVGAVLVLLMLSSSVPSALYVLYQQRWGLSAGVVTVVFAVYAVTVLAGLLLFGSLSDTLGRRPVLGAGLVLAIVSMGLFAGAGGLGLLLAARAVQGLAVGLATGAMGAALLELSPRSRPALGAQVNSAGPTVGIGLGGLGAGLLVQYAPAPTVLSYLLLVVAFAVTLVGVVRMGESAPGAGGRFRVVPHRIRVPAAVRRRFAVLVLTVVAVWTVGGFYLSLGPHLALSLLHTTNYLAGGATVALLAGSATCAQLLLGRTEPLRTAVLGLLGLLAGLALVLLALGLGSAPVFLVATAVLGSGWGAAFLGSFRAISTLAEPEHRGELTAAVYVFAYLAMSVPAVLAGLLTNIHGLQRTSVGFMAAVAAVCALALFTTLRLAARTRAEGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTH9</accession>
    <name>A0A0F4JTH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946184.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7119"/>
    <dbReference type="EnsemblBacteria" id="KJY37672">
        <property type="protein sequence ID" value="KJY37672"/>
        <property type="gene ID" value="VR44_05310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1697"/>
    <dbReference type="eggNOG" id="ENOG5032URQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="16209" checksum="8DF3FD1F4ECCDF89" modified="2015-06-24" version="1">MPAERLTEDAIRTFAENWYVALDRHLPLEQVLALITEDLEFKVPEDTFLGHQGFGRWYEAVTNRFFDEVHTVTKVEPVIEGDRAIVRVLVNWQAKIWDPPAARSQWLGFDADQTWTVVAGADGPLIKQYTVNELAPMPGSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTK8</accession>
    <name>A0A0F4JTK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000166">
        <property type="protein sequence ID" value="KJY36316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36316">
        <property type="protein sequence ID" value="KJY36316"/>
        <property type="gene ID" value="VR44_08170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4383"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease_alpha" evidence="4">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20805" checksum="996BD62AA53401B1" modified="2015-06-24" version="1" fragment="single">MSRQTPHTDHSAHCAPGSRHIDPREYASVFGPRAGDRVRLGDSGLTVRVEYDAQKPGDEFLAGFGKTARDGLHLKGAAVRETCDVVISNVLVIDAVLGIKKVSIGIREGRIHAIGRAGNPDTLDGVDVVVGTGTSIVSGEGLIATAGAVDTHVHLLSPRIMEASLAAGVTTVIGQEFGPVWGVGVNSPWALKHAFNAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU52</accession>
    <name>A0A0F4JU52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946343.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37288">
        <property type="protein sequence ID" value="KJY37288"/>
        <property type="gene ID" value="VR44_06155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15359" checksum="641FA741B5439B9D" modified="2015-06-24" version="1">MAESGRARVRIGITEVSGPSMVPTLLHGDRMVVRYGALVRPGDVVVFRHPLQQDLLVVKRAAERRPGGWWMLGDNPFNETGDSTDYGAVPDDLVLATAVLRLRPRPAHQSSLRARLSWALSAVRPLRADSSASRRLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU59</accession>
    <name>A0A0F4JU59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946346.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37293">
        <property type="protein sequence ID" value="KJY37293"/>
        <property type="gene ID" value="VR44_06070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2550"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="36364" checksum="2D639A9EE20DA48E" modified="2015-06-24" version="1">MALMAAHTIAAGEGQEAAVLLDRARESVDPELRRAVESLPALTRRVAMYHFGWEHEDGSPAAVGAGKAIRPALVLASARALGGPQGSPESVVRAAAAVELAHNFTLLHDDVIDNDARRRGRPTAWTVFGIPDALLAGDAMMALALRMLADDPHPASARASARLAACIVELCAGQQADCAFERRTSVTLEECLAMATAKTGALLGCACAVGALYAGAGPEEVDAMDAFGREAGLAFQLIDDLIGIWGDPGHTGKPAGADLVARKKSLPVVAALTSGTGAGEELAALYAGPMTGDDDVRRAARAVERAGGRDWAQAHAGDRMGRAVQELSRAVPDVAAAGGLLALAEFVTRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUR3</accession>
    <name>A0A0F4JUR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945984.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38102">
        <property type="protein sequence ID" value="KJY38102"/>
        <property type="gene ID" value="VR44_04180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.125"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470898" evidence="1">
        <location>
            <begin position="37"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="36698" checksum="99EE77AC7A6653DF" modified="2015-06-24" version="1">MPKPSPTFLSRRGLIAAGGALGLVAALTACGGGDKAKDGAGDQGSSAASGAWSFKDDLGKTASAKSTPKNVVAYTGTAAALYDYGVQVKGVFGPTKLADGKPDPMAGTMDISKVEILGNVYDEFNVEKYAALRPDLLATNTWDGSYWYVPEASKDKILKLAPAAAIGVGDKVSMDKALERTADLAKSLGADLNTRKSADAKARFDAASAKVREAVKANPGVKVLVGSGSDQMFYVSTPKTSADLKYFESLGVEFVTPEQDKLDPQGFYESLSWENAGKYKADVILLDNRTQALQPEALKAKPTWNELPAVKAGQVAPRVTEPIYSYEKCAQLLEDLAKTIQNAKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV64</accession>
    <name>A0A0F4JV64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042817977.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37734">
        <property type="protein sequence ID" value="KJY37734"/>
        <property type="gene ID" value="VR44_05160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1347"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11517" checksum="5B199ECBAB3D5F47" modified="2015-06-24" version="1">MKFDMGSTTLSDLGKATSGSSDDLGTLIKLLIAAADPLEGKFNGVGRTAFDSFKRRSDAVTAELNGSLRAILGGQRGMDTSFTTGDHEQGDNAHQNMGSANFDAARFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVF8</accession>
    <name>A0A0F4JVF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000127">
        <property type="protein sequence ID" value="KJY36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946479.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000127.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36931">
        <property type="protein sequence ID" value="KJY36931"/>
        <property type="gene ID" value="VR44_06855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3455"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="35315" checksum="0772C6A17CFB57D5" modified="2015-06-24" version="1">MSTGTADTAARRARPFPAVSPRTRTRVPLLVTAGLLVVMFGVGSVRYEGFLSAQVVLNLLIDNGFLLVVAVGATFVILTGGIDLSIGSMVALSTMLTAWLVQSHGWPLAAVIPLVLLTGAASGALMGWIIHTFEIQPFIVTLAGMFLARGLCYTISTESITIDDPATTGAAQTRLYGPGGLFVSIPVLIALAVLVTAFVVLHHTRFGRNVYALGGNESSARLMGLPTGATKVAVYGVSGLCSALGGLLLTLYTLSGYALHAMGMELDAIAATVIGGTLLTGGSGFVLGTALGVLVLGMIQTLVNFQGTLSSWWTRIVIGALLLVFIVLQRLLGGRRSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVR8</accession>
    <name>A0A0F4JVR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_03655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945896.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5769"/>
    <dbReference type="EnsemblBacteria" id="KJY38447">
        <property type="protein sequence ID" value="KJY38447"/>
        <property type="gene ID" value="VR44_03655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8269"/>
    <dbReference type="eggNOG" id="COG1966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="47"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="479"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="733" mass="77252" checksum="C26381DB2E869CD3" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWX1</accession>
    <name>A0A0F4JWX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945787.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38635">
        <property type="protein sequence ID" value="KJY38635"/>
        <property type="gene ID" value="VR44_03070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7829"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="18033" checksum="F3899F396D87260C" modified="2015-06-24" version="1">MTDTPTTATTSISRMPNPGEFVPELADISAALFRATGNRSVPRSTISLVHLRAGQIVNNTYLTILNTGFLRKAGVSEEQITAVASWQDALCFSPAERAALALVEATLQPAAPGKERVSDELYAEAAKHYDEKALATLTIAIGQINFFIALAVIGKPHPVETLAARQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXJ0</accession>
    <name>A0A0F4JXJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_03670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945893.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38443">
        <property type="protein sequence ID" value="KJY38443"/>
        <property type="gene ID" value="VR44_03670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8272"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="37895" checksum="53E9373C3B11D0BA" modified="2015-06-24" version="1">MTVHSQGATTSAPQDAPHQSAGRPKAQSPAAGPRPTPPRGGRKQLPSGWLPYLLVLPAVASMALLLLYPLIKNVILSFQDINKIEFIQRKYPFGGFANYTQLIGDSNFWTVVVRSFLFTFANVALIMVIGSLIGILLNRLGKWMRLVLSMALVMAWAMPIVASVQVFYWLFDEQFGVMNWVMRTLGFSGYEQHNWFETGLSTLTIVTLLVVWGSIPFVALNMYAGLTTVGAELYEAARMDGANGWQTFWKVVFPNLKPFFLVTTFLEVIWVFKAFTQVYAMNKGGPDRASEILPVFAYVEGQSQAHYGLAAAISVLTILILLVVMSFYFRLILKQEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXV4</accession>
    <name>A0A0F4JXV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD, TfdA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945580.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39212">
        <property type="protein sequence ID" value="KJY39212"/>
        <property type="gene ID" value="VR44_01975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5801"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="126"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="38732" checksum="6F2979C0E81D9356" modified="2015-06-24" version="1">MKAIYTFSETDRASLSDSLTFLGANPYTDYEKFRDAIGNLIADERVPAGFVDACRRIKQQRDDKVTYAHVVSNCPLDVDRPVFDQANPVDDKYLQKQTFVGEGVLELLAQLTATPLLSYATRNNGDFFHDVYADNRYSGTQTQKTDWELYWHNDRTAHPVRADYLALLGMRCPTDDLVYTKYVDGRELLKFISPENQELLREKAFVTPYDELSRASNRKQQVSDLHTLLENEHSFRYYDTRTMPADPSSAAHYEALRQFRDALAKSREQYHRIQEGDLLVIANQDGLHSRQMVDIQHFETTRLRWLLKTYAFRDDAAADVHGDIWLDGVRGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYG5</accession>
    <name>A0A0F4JYG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000081">
        <property type="protein sequence ID" value="KJY38021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946027.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4253"/>
    <dbReference type="EnsemblBacteria" id="KJY38021">
        <property type="protein sequence ID" value="KJY38021"/>
        <property type="gene ID" value="VR44_04415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.452"/>
    <dbReference type="eggNOG" id="ENOG50318WM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23105" checksum="459B5F1425A6F5EE" modified="2015-06-24" version="1">MAAAQGRFSDGADGVDGAKESSVPLPFRRAVDGLRKARLRPGIEIDPTKPPQRLAPYAYALEAAVVDGEEDLADGRLILLHDPAGHDAWQGTFRLVTLVRAELEPEMAADPLLPEVCWSWLTGALEARGLAYGEPSGTVTMASSHYFGGLGERRPATQIEIRASWTPREGVGGVPDTSAHLASWCELLCQIAGLPPAGPAEGAPGVVSLPQRRGPHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYV1</accession>
    <name>A0A0F4JYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945555.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39325">
        <property type="protein sequence ID" value="KJY39325"/>
        <property type="gene ID" value="VR44_01865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5777"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="413" mass="44427" checksum="657137844DB3A2D4" modified="2015-06-24" version="1">MKVCVIGSGIFGIAAVREISRHLPEWSVHWVSEDPEAGGLWNTASKRSRVYDTLFLNTSRQRSAFTGTAIPAEPSVHFVHHSLYSAYLAEVAAGCQGPQRHWECRVDSVSAREGGGWLVRWHDRTGAGTEEEFDAVVDATGHNVEPVWPDVPRAAGTTYALSHSAEYRNAEPYRGKRVLVIGNGASAVDIACELTSAASRVEISIRTPKWYLPKVLLGKPIDHSGGGLSHAPLVGRVIARVGESVVRRVVGSYDSFGLEVPRSPLAVSTPVLSDHFLPHLSHGRLHARTGVVALEQESVRFADGTEGTFDAVIAATGFQDASPHLPADVRDTLSRRRLGLSLEAPGSPGLYLLNRFRCGDSAVKCAEVQAAAVARCLPGSRSRSGAPPVLAGPEVPGGRITARTLRKVYEAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYY8</accession>
    <name>A0A0F4JYY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945446.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4711"/>
    <dbReference type="EnsemblBacteria" id="KJY39597">
        <property type="protein sequence ID" value="KJY39597"/>
        <property type="gene ID" value="VR44_01165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2947"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="591" mass="64369" checksum="4844C2090C850926" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZJ1</accession>
    <name>A0A0F4JZJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000018">
        <property type="protein sequence ID" value="KJY39530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945475.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39530">
        <property type="protein sequence ID" value="KJY39530"/>
        <property type="gene ID" value="VR44_01400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4712"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046081">
        <property type="entry name" value="DUF6099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19594">
        <property type="entry name" value="DUF6099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="16624" checksum="09C5E111E37EC26B" modified="2015-06-24" version="1">MDAVRLIAAGRHALARSAAAWDIVGEAWQAQALAQGVGSWLAVTGPPELRAEARGLGEAGSRGCGAVDRAALGEAEGAAPDQPPRAAQLTGVADLRQALLGLQALLGEVGIALVGVACATDDEGLYWQCIESIDAADESSDRVRALLRRMTVRERGSASGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K001</accession>
    <name>A0A0F4K001_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">VR44_03180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945809.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6558"/>
    <dbReference type="EnsemblBacteria" id="KJY38606">
        <property type="protein sequence ID" value="KJY38606"/>
        <property type="gene ID" value="VR44_03180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7851"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="21785" checksum="B8FEC09F8932F4F4" modified="2015-06-24" version="1">MYEGVVQDLIDELGRLPGVGPKSAQRIAFHVLQAEPTDVRRLAHALLEVKEKVRFCAVCGNVAQEERCGICRDPRRDATVICVVEEPKDVVAIERTREFRGKYHVLGGAISPIEGVGPDDLRIRELLARLADGTVTELILATDPNLEGEATATYLARMIKPMGLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0P7</accession>
    <name>A0A0F4K0P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_01475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945488.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39498">
        <property type="protein sequence ID" value="KJY39498"/>
        <property type="gene ID" value="VR44_01475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4728"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="218"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="39194" checksum="16BFD16208F38B3D" modified="2015-06-24" version="1">MAGFALGVEQEEWCGQLRALAERRLRPLAEKGEPGRVNRPLLAELGELGLLERVFGSGALELCLLRESLAYGCTEAETALALQGLGGHPVLRAGTAAQRERWLPGVRAGRLVAAFALSEPGAGSDAAALALAAAPDGAGWRLEGAKCWISNAPEADFYTVFARTGEAPGAKGITAFLVPADRPGLTGEALDMLSPHPIGSLSFDGVPVGREDVLGGPGQGFRVAMETLNLFRPSVGAFAVGMARAALDATLAHTAGRTAFGGVLADLQAVAHRVAEMATRTEAARLLVYAAAGAYDSGSPDVPRRAAMAKLLATETAQYVVDHAVQLHGAVALRRGHLLEHLYREVRAPRIYEGASEVQRGIIAKELYRGVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1F8</accession>
    <name>A0A0F4K1F8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">VR44_00365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005313525.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1041"/>
    <dbReference type="EnsemblBacteria" id="KJY39949">
        <property type="protein sequence ID" value="KJY39949"/>
        <property type="gene ID" value="VR44_00365"/>
    </dbReference>
    <dbReference type="GeneID" id="67399250"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.71"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="7002" checksum="F27CEBAB7345E4EE" modified="2015-06-24" version="1">MARLKITQTKSYIGSKQNHRDTLRSLGLKRLNDVVVKEDRPEFRGMVHTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I452</accession>
    <name>A0A0F4I452_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001723">
        <property type="protein sequence ID" value="KJY16712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16712">
        <property type="protein sequence ID" value="KJY16712"/>
        <property type="gene ID" value="VR44_40315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7199" checksum="F12A6C5880744D07" modified="2015-06-24" version="1" fragment="single">LITGGTGALGRLVAAHFITTHGVRNILLTSRRGPDTEGAAALQEELTALGATVTVAACDAADRDALAALLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB36</accession>
    <name>A0A0F4IB36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001595">
        <property type="protein sequence ID" value="KJY18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001595.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18693">
        <property type="protein sequence ID" value="KJY18693"/>
        <property type="gene ID" value="VR44_39490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5987"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41675" checksum="2057A367C06759DC" modified="2015-06-24" version="1">MSGEQTEVLVIGGGYAGVMAANRLTRRADVNVTLVNPRPEFVERIRLHQLVAGTDDAVVEYRKVLGERVRLVVDTVTRIDTAGRAVTLAGGGTARYDYLVYAVGSGSADPRVPGAAEFAHPLATLEEARRLRPALDAAPSGAPVTVVGGGTTGIETAAELAAGGRAVTLVCGGALGPSLHPRGRRAVAGRLAALGVTVVEGPGAKVTAVTRETVRLADGRELPSAVTVWTAGFGVPDLAARSGLSTDALGRLLTDETLTSVDDVRVIAAGDSAAPSDLPLRMSCQAAAQTGPQAAETVLSRIAGERPAPIEVGFVAQCVSLGRRDAVLQFAAKDDTPRKYVLRGRPAAKVKELICRSVPWQLAYEARKPGVRTWWTKDPKRQELLRARAAGDPAAAAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEQ5</accession>
    <name>A0A0F4IEQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001527">
        <property type="protein sequence ID" value="KJY19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19938">
        <property type="protein sequence ID" value="KJY19938"/>
        <property type="gene ID" value="VR44_38900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5496"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="33971" checksum="B3E04EEFFC7FC1D9" modified="2015-06-24" version="1" fragment="single">GGVMIGDVEGHDTDAAAVMGQLRIVLRAYVLEGHTPGTAMARASAFLRDLATERFATCTYAEADLNTGMLRLVRAGHLDPVVRRGDGSCHRVQVAGGLPLGLPPREPPSGTGCGYPVTSMELHPGDTLLLCTDGLVERPGGDLEAGIREFMDAACQGPADVEELADVLCDLVGDAGGGDDMALLVLRRRGTAAPRGGGPLRQRLVPGDTEGPAQARHLIRAAAAAWGARERADEIELAADELMTNALVHTDGGGQVGMRLTAEGRIRVEVEDSSSALPRRREADDWAVSGRGLMLVDRLADGWGVEPRGSGKCVWCEFTVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFZ6</accession>
    <name>A0A0F4IFZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_38700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="JZWV01001504">
        <property type="protein sequence ID" value="KJY20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952371.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001504.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20403">
        <property type="protein sequence ID" value="KJY20403"/>
        <property type="gene ID" value="VR44_38700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5418"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="48745" checksum="3EB9DA3748AE487C" modified="2015-06-24" version="1">MSDDEGEPEPVSHDLRAEKAVLRAMLVSTDAIADVVEILHGHDFYRPAHELIYNSILALYAAEKAPSPFTVCAHLEEAGQLDRAGGRAYVNSLVSTASGKDWARNAERVQATSRLRRLHTAAIHIENLVAEASPENVDKVANAAEAEILAATTSRPGSLPPAFSIGDVLEDTLDELEAIGSRKATLAGVPTGFQDLDLLTGGLQPGQLIVLAGRPAMGKSTLAGDFLRAAAIKANLPSTLFTLELRRTEVTMRILAAEARVALHHMRAGTLTDDDWTRLARRMPDVSAAPLYIQDSAYATFTDLRAQCRRLRSQRDIALIVVDALHMLTYGTRPFSSRYEEISEIARCLKLLAKELDIPVVAVSQLNRGPEQRTDKKPQISDLRDSGALEDNADVVILLHREDAYEKESPRAGEADLIVAKHRNGPTATITVAFQGHYSRFVDMAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILG9</accession>
    <name>A0A0F4ILG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001424">
        <property type="protein sequence ID" value="KJY22338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952228.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001424.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22338">
        <property type="protein sequence ID" value="KJY22338"/>
        <property type="gene ID" value="VR44_37940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5152"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="252"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY22338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="35978" checksum="951CF34CC5E61BDA" modified="2015-06-24" version="1">MPIQPCEPQPRVGITAVGSLLPEDVLSSDDLQREVTRRSGIALPDRMLTLATGIVSRRVAPEGVYASTLAAGAARRALDAAGLDPLDVDLLVFASASRDLVEPATAHIVQAELGSRAHAVDVTNACNSFVNGIDLARGMVLAGRSRRALVVTGETPSRAVRKDPADFAEFRGSFAGYTFGDAGAAVVVEPVERGGILDVDGETHSEHWEVGGIPGGGSRHPRGDAYTYFQGDGHELRGVFEKAGTAVIDRTLHRTGMGWDGFSKVLVHQVTVPYLERFAELTGVPQDKLVVTVPELGNVASASIGVQLDRIFGELDSGERVLFVGLGGGISIMTMVWEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ87</accession>
    <name>A0A0F4IQ87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001349">
        <property type="protein sequence ID" value="KJY23839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952072.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001349.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23839">
        <property type="protein sequence ID" value="KJY23839"/>
        <property type="gene ID" value="VR44_37095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4807"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="29270" checksum="A789040406BE15FA" modified="2015-06-24" version="1">MADHDLTGFAKSTFTHGGTTRRVLRRGTGPAVIIMAEIPGITPKVLEFAAHVADAGCTAVLPVLFGTPGRDANPASGGWPNTARALASTMGQVCVSREFTVLATGRSSRVVGWLRALAAAEHERCGGPGVGAVGMCVTGGFALAMAADERMLAPVLSQPSLPLPCTPGRAGTIDISPRELAVVRGRCEREGLQVLGLRFKGDRLVPGERFAFLRRTLGDAFVAVELEDNTANPEAALPPHSVLTEHLVDEPGQPTRQALDTVLDLFREKLLGEPSGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQT4</accession>
    <name>A0A0F4IQT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001309">
        <property type="protein sequence ID" value="KJY24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24019">
        <property type="protein sequence ID" value="KJY24019"/>
        <property type="gene ID" value="VR44_36540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470057" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="14338" checksum="80DB28380844BB46" modified="2015-06-24" version="1" fragment="single">MVAALAAAAVLTAILPAAATGGTIWTTLPSMPTARAGVASAAAPCPPGQTGICVYTVGGENLAGQPLASAESYNRITNAWSTLPPMPTARSNAAAATAACPPGQTGTCLYVIGGVVISGESQTPQTVVQSYNPVTNAWSTVAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQZ3</accession>
    <name>A0A0F4IQZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001295">
        <property type="protein sequence ID" value="KJY24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene287"/>
    <dbReference type="EnsemblBacteria" id="KJY24089">
        <property type="protein sequence ID" value="KJY24089"/>
        <property type="gene ID" value="VR44_36350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8244" checksum="D550EA37E544C898" modified="2015-06-24" version="1" fragment="single">GFPRDRADQLAAVASGLTSLTAGASRIFEGGAVNQTVVEMDRGFLFLMSVSDGSSLAVLAHPECDIGLVGYEMALLVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRG1</accession>
    <name>A0A0F4IRG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001302">
        <property type="protein sequence ID" value="KJY24058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951947.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001302.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24058">
        <property type="protein sequence ID" value="KJY24058"/>
        <property type="gene ID" value="VR44_36435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4539"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469754" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12299" checksum="51F5F4855EA4A5D0" modified="2015-06-24" version="1">MSQIRRIGVMTGVAALLLAGTACSADRTTVGTLTFRGHDSPVEVSYANTSVQGCHRIGIPHGATHVANNTLVDVILYRTPDCRHGQQEDGIYVATTLSNVTAPSSLPWRSWSVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISJ6</accession>
    <name>A0A0F4ISJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001142">
        <property type="protein sequence ID" value="KJY24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24962">
        <property type="protein sequence ID" value="KJY24962"/>
        <property type="gene ID" value="VR44_33820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3689"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="44738" checksum="4913113C31C2E910" modified="2015-06-24" version="1">MRRWTGPLVGARARLRWVHLILGGALLMPYLLLAQVVVGAAAGGVNVLASLPLTLLSYAASLPLVALTGLFGLVRPLSATAARAMTGVPGDRLADGPARSWAARRRASAWWTLHLGIGALVSGMSLAVPPMAVVLIVMPLSGTLRASVWGTYLFSAEAEPYLSPLLGAGLLAGLAAVCAGAGALLARLAPVLLGPTAADRLAAAEERAADLAVRNRLARELHDAVGHALSAVTLQAGAARRVLDSDPAFVREALAAIEETTRRTVGELDAVLGLLRDGDPARADAMPAPTLAGDLDGLLARTRAGGTVLTAEQDPGPAGDWAQLPAIASREAYRIVQEGLSNALRHGTGPITLLIRVHTTDGSRELEITMTNPPAPPPHAHDGGRPRTGGGRGLRGASERAALLGGRVEAGPHGETWRLRAVLPLGTTTAPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITZ5</accession>
    <name>A0A0F4ITZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001068">
        <property type="protein sequence ID" value="KJY25480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951197.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000071_gene5881"/>
    <dbReference type="EnsemblBacteria" id="KJY25480">
        <property type="protein sequence ID" value="KJY25480"/>
        <property type="gene ID" value="VR44_32365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28946" checksum="5763A6843CEC6FF6" modified="2015-06-24" version="1" fragment="single">MAATEPLPLAGLTVVAVEQAVSAPFATRQLADLGARVIKVERPDGGDFARAYDTAARGLASHFVWANRGKESLALDLKDPRGLEVLHALLDGADVFVQNLAQGAAARLGLDAAALCARYPRLVAVDISGYGEGGPYAHKRAYDMLVQCEAGLVSVTGTPERPVKAGIPAADIAAAMYAFSGVLAALLRRGTTGRGGPVEISMLESLAEWMGHPLHHTMHGGEQPVRTGLAHAVIAPYDAYATADGDRVLLSVQNDREWRRLAREVLERPELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU61</accession>
    <name>A0A0F4IU61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001133">
        <property type="protein sequence ID" value="KJY25013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001133.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25013">
        <property type="protein sequence ID" value="KJY25013"/>
        <property type="gene ID" value="VR44_33670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3643"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469801" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="138"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26701" checksum="ED1E4F63F000AD05" modified="2015-06-24" version="1">MRKHRKKTHYRKIAVAVGALAIVGVPTAAMACLDPQETGRAHTAATAWQERHPSSSGPEAQPQAEVPVETGPASELPDEVPPAPVEPVTEQPAEQPAGQPAAAPPAAPRPQAPAAEPSAAPPAPQASGAQTDAQAKVLALVNQERAAAGCPAVTVNAELTKAAQDHSADMAAHATMSHTGSDGSDPGQRITRAGYQWQTYGENVAYGYSTPEQVMEGWMNSPGHRRNILDCSYREIGIGLAQPGQYWTQDFGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF1</accession>
    <name>A0A0F4IUF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001120">
        <property type="protein sequence ID" value="KJY25103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951389.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001120.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25103">
        <property type="protein sequence ID" value="KJY25103"/>
        <property type="gene ID" value="VR44_33400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3558"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19128" checksum="CC89F9607678E5DC" modified="2015-06-24" version="1">MAEHEESSGGVPPLDEEAAWAAIVAGYGQEPPDPPGARPFRPIENLMLPEEDVQPEPPAAAPTTPTALGSSVVFAPGVVLGPRDHSPAEPKDEDLAGDAADEGHFVPPEPPELPPADTTAKFAWLAVVGGPVLLLLAVLLQWDMTWWLTTLGIGGFLGGFATLVARMSGDTDDNDDDPGRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVA8</accession>
    <name>A0A0F4IVA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001193">
        <property type="protein sequence ID" value="KJY24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951642.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001193.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24621">
        <property type="protein sequence ID" value="KJY24621"/>
        <property type="gene ID" value="VR44_34810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4033"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="420" mass="43066" checksum="FF0EABED7E24D144" modified="2015-06-24" version="1">MAVPGDPPNGTPEGTGGGDDELRPDEYRSVVFDEDFVRAARLQEFSAQERMGEHARAVRSRSIWSGGGSAGRGNGTPGRGARQGMLLVLLIASAFAVAVYLGLRNPYVPPAGGNAEPLSSTVVPLTPSSAVPGGKPADLYARSPAAEYRTGAAGITLPAVRRTHHFTESQVVAALSIAKDYLVQSSLDPDVLSGTASRPVRVLLDPGQLAQFDESMTSPSGDGRHAATGWLVRFDPQTAALADSRVRVSGTLAFEEVSPEALVVTTDHTFVYAVRGASGPPAGSDASSLFTVRRELRLRFDHEDLTTRRAELASSYVMAGPQDCAADPAGGFRPLLAGAGPTTVGPPVSDPYASGHPRRTAGLCGVMDPAAAAPDPSAQPPSAQPAASSPPPQAGPADAGAVPAARPQAPPPPASVSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVZ9</accession>
    <name>A0A0F4IVZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001156">
        <property type="protein sequence ID" value="KJY24866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24866">
        <property type="protein sequence ID" value="KJY24866"/>
        <property type="gene ID" value="VR44_34115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3749"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34748" checksum="766E4FFD7B12FBAF" modified="2015-06-24" version="1">MSWPWDRTDGWGSLLPDVQAEIAGIARSIARSEPVLMFAEPGHTDEARAQCGPTVTVVEYPVNDCWTRDTGPIFALNAAGSRRIGLDFGFNGWGGKYPFDKDDLLPVGVCDHLGVERRDVPMVLEGGSVITDGQGTLITTEECLLNPNRNPTMTRAQIEATLLAAYGATKLIWLPYGLANDTITNGHIDLVAAYLGPARILLHTQPDTSSPNHDRMAANKAVLDAATDACGRRFELVEMQQQPHFRQNGLMVETFSYTNYYLTSAQVIVPQSGEAAADAAALDRLRPLFPGREVVGTPARILAWGGGGVHCVTQHVPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW74</accession>
    <name>A0A0F4IW74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001148">
        <property type="protein sequence ID" value="KJY24916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951487.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001148.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24916">
        <property type="protein sequence ID" value="KJY24916"/>
        <property type="gene ID" value="VR44_33945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3715"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="19636" checksum="D816AF80B2F9C704" modified="2015-06-24" version="1">MIIDDGIVFRAAEEKDAGVLVKLYDQAARWMRKQGIDQWKPGEKDAAHFRGKMRDGEVWLAADADGQVVGAYELWWSDEEAWGVQPPVAGYVHRLMVDRETAAPGTGLRILEHAEHRIARTGRERARLDCVSTNPRLLAYYQGAGYRVVGEFPSKQGKDGRVYGVILLERRLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWA9</accession>
    <name>A0A0F4IWA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001144">
        <property type="protein sequence ID" value="KJY24946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951478.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001144.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24946">
        <property type="protein sequence ID" value="KJY24946"/>
        <property type="gene ID" value="VR44_33895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23516" checksum="476D8D75B61EF6E7" modified="2015-06-24" version="1">MADTPGRIRVLLVDDHQVVRRGLRTFLEVQEDIEVVGEAADGAEGTDRAEELRPDVILMDVTMPGTDGIEALRRLRDLGNPARVLIVTSFTEQRTVVPALRAGAAGYLYKDIDPDALAGAIRSVHAGHVLLQPEVAEALLAAQDDQGAPAGRPGSLTDREREVLGLIADGRSNREIARALVLSEKTVKTHVSNILMKLDLSDRTQAALWAVRHGITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY19</accession>
    <name>A0A0F4IY19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001057">
        <property type="protein sequence ID" value="KJY25561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25561">
        <property type="protein sequence ID" value="KJY25561"/>
        <property type="gene ID" value="VR44_32185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3158"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17404" checksum="0F8306881CF031D0" modified="2015-06-24" version="1">MELLRASLDPASHREDVVSKLDLPTGRLIAAAAHADADDNGADRLANLAGGLALAALGLSAEVASRGEKTLEEFLDGLEQAGDDEVHKLMVATIRGMLHDQGVEVMGRTLAQDQARFLDLLLALTSYCGTSILALQAIGTPAETTLADLEDALRDEDDEAEPAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ73</accession>
    <name>A0A0F4IZ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000848">
        <property type="protein sequence ID" value="KJY27330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950378.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000848.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene200"/>
    <dbReference type="EnsemblBacteria" id="KJY27330">
        <property type="protein sequence ID" value="KJY27330"/>
        <property type="gene ID" value="VR44_27875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1815"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18874" checksum="C25EA467A54A1834" modified="2015-06-24" version="1">MADTAAIIESTLSGAELTWENPQPGTYVVQLPGTRKLSTTCSLRVGRHSLSLNAFVIRHPDENEAGVHRWLLERNLKLYGMAYAVDPLGDVYLTARLPLSVVTPDDLDRLLGTVLEAADGAFNTLLELGFASAIRREYEWRTSRGEPTHNLDAFKHLTRPTAPLPDAPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZG5</accession>
    <name>A0A0F4IZG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000894">
        <property type="protein sequence ID" value="KJY26878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950580.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000894.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26878">
        <property type="protein sequence ID" value="KJY26878"/>
        <property type="gene ID" value="VR44_29005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2134"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="419" mass="44383" checksum="AD0BB2B743C92CB4" modified="2015-06-24" version="1">MTSTGEERDGAGRDGPWWWERRRGAVLDVGLGAVSAVECAVEGVPFAHEAGLPVPLGVVFGVVVGAVLVLRRRWPVAVVLVGIAVTPAAMGFLLGVVGLYTLAACEVPRRVTGTLASMSLVGTFVVTYLRTRGDVEGEGALVFVLSAFMAVALTVPPVLLGLYVGARRRLMESLQERADSLERELSLLADRAEERAEWARQEERTRIAREMHDVVAHRVSLMVVHAAALQAVAGKDPEKAVRNAALVGDMGRQALTELREMLGVLRASEKPVRAVAAVADVVAPVAVVEEGPSLAELEVLVGQSRAAGMSVEMVVQGEGRAYPAEVEQTAFRVVQEALTNCHKHAPGARVVVRLAHREEEVAMQVENGPREGEARGADLPSGGNGLVGMRERVLGLGGVFVSGPTDGGGFKVSAVLPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZK2</accession>
    <name>A0A0F4IZK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000833">
        <property type="protein sequence ID" value="KJY27440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27440">
        <property type="protein sequence ID" value="KJY27440"/>
        <property type="gene ID" value="VR44_27530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="660" mass="67308" checksum="7242AAE313C8B5AB" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J036</accession>
    <name>A0A0F4J036_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000812">
        <property type="protein sequence ID" value="KJY27630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950252.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000812.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6904"/>
    <dbReference type="EnsemblBacteria" id="KJY27630">
        <property type="protein sequence ID" value="KJY27630"/>
        <property type="gene ID" value="VR44_27190"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470443" evidence="2">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="43135" checksum="1881A12FCEDE1E1A" modified="2015-06-24" version="1" fragment="single">MFRRTLNCAAVPAIAALTVLAGTAPAHADQIPQAPGHRLVSHYDGAPAAAAPLRGEAPPQHPFLAPNGRSGMHSDAGGSATSPWSGPLGRNPRVTSEKIAALGGECATATFDAGGRLVTVCGTFSGFEVKLLEPRTLATLAEHKLPQRSSTVEAITSLDFSKIFKDTSGGAYFYLDDQDRAVLADSRQHVLRLAHSQNPDGSWRFTVDGDWDLTGQVPHDCVSWTNLWPSGTCDPVTSVMPDWNGLIWWVTRQGRVGTVDPQTSRIRSIRLEGEEIQNSFSVAEDGVSIVSDHALYSFHAGADGTPEALWRQTYDRGTGTKPGSVNQGSGTTPDLFGNGYVAITDNADDRMNVLVYRRGADVPADRRLVCKVPVFGSGASTTDNSLITWGNSIVVENNYGYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Y3</accession>
    <name>A0A0F4J0Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000838">
        <property type="protein sequence ID" value="KJY27408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27408">
        <property type="protein sequence ID" value="KJY27408"/>
        <property type="gene ID" value="VR44_27600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1756"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="56"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="23032" checksum="86AFCC4A7E574AD8" modified="2015-06-24" version="1">MEAEGLVTSSRGVGTMVRAQTPLKRIGISRYDKAKWRDGDEVAFIADRVVSGRAYQRGEQTQSVSLVEAPAAVAEAHGLPEGAQVYARARLVKEGEQPTHTLTSYYRPEHVEGTRIVDPTPGPAGRGGGFRVLYDAGYEIDHMKERIFARVPTSDEVKLPAGEPVVELHRTTYTADGTVVEFAVGVHAASWFAWEYEFKVPDSAQDGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1H1</accession>
    <name>A0A0F4J1H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000762">
        <property type="protein sequence ID" value="KJY28117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28117">
        <property type="protein sequence ID" value="KJY28117"/>
        <property type="gene ID" value="VR44_26030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1359"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17075" checksum="4F335F2342060E89" modified="2015-06-24" version="1" fragment="single">LATARRNAAWSLARGGREYGRGHYPAVVGLHVALLAGCAAEAVHRPFLPALGWPALAVAVAAQGLRWWCVLSLGPRWNTRVIVVPGLPLVAAGPYRLLRHPNYAAVVLEGLALPLVHTAWVTALGFTLLNALVLRVRIRCENSALTYARTADPLLGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1R2</accession>
    <name>A0A0F4J1R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000808">
        <property type="protein sequence ID" value="KJY27668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27668">
        <property type="protein sequence ID" value="KJY27668"/>
        <property type="gene ID" value="VR44_27075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1577"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="8807" checksum="FA6E989D4833BCEC" modified="2015-06-24" version="1" fragment="single">LDAAHVAAYESVSGPATATVRLLGLDPFEASAVLAGLAPDLDAVAARAAEAALLARTEGTDVLPAASSPLLDIAAEVHADWAVRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J234</accession>
    <name>A0A0F4J234_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000741">
        <property type="protein sequence ID" value="KJY28315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949956.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000741.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28315">
        <property type="protein sequence ID" value="KJY28315"/>
        <property type="gene ID" value="VR44_25615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1222"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="22491" checksum="8C179F77F2110CA8" modified="2015-06-24" version="1">MSTREPSAGPASATDRRTLIADTAIGLVAASGLRGLTHRAVDAAAGLPAGSTSYYFRTRTALIAAGYRRLAELDVSEVPSSLPTDRDEAARALGTLLHHWLTAGRERQLARFELSLEAARNPELEPDLREAGLAVRARAAAVLAALGAPNPQESAELLAAWTDGLLYDRLAGALAPSRPTPDPAELTSTVRRMLDAVLGTSAQDPAAYHPGPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3K2</accession>
    <name>A0A0F4J3K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VR44_24345</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000697">
        <property type="protein sequence ID" value="KJY28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949721.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000697.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5248"/>
    <dbReference type="EnsemblBacteria" id="KJY28860">
        <property type="protein sequence ID" value="KJY28860"/>
        <property type="gene ID" value="VR44_24345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.851"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="17">
        <location>
            <begin position="39"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJY28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1531" mass="164519" checksum="F1F7156C9A447B32" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3N3</accession>
    <name>A0A0F4J3N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000731">
        <property type="protein sequence ID" value="KJY28439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949908.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000731.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28439">
        <property type="protein sequence ID" value="KJY28439"/>
        <property type="gene ID" value="VR44_25365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1169"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="647" mass="68603" checksum="A3AB9EEC8F9AD522" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3T9</accession>
    <name>A0A0F4J3T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28383">
        <property type="protein sequence ID" value="KJY28383"/>
        <property type="gene ID" value="VR44_25495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1197"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7664" checksum="D737F209EB9D2B5D" modified="2015-06-24" version="1">MDPHTKATQIAPFTAVPGPRHPAVPAQAPTGHITSTAERGSFCLAVCSCGWTGPARRSRDLARKDATRHGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4L8</accession>
    <name>A0A0F4J4L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949774.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2993"/>
    <dbReference type="EnsemblBacteria" id="KJY28774">
        <property type="protein sequence ID" value="KJY28774"/>
        <property type="gene ID" value="VR44_24630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.921"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="34312" checksum="BB7B679A48078D30" modified="2015-06-24" version="1">MTAGATGVGSLPGGDAREAAKTATGSFEDFPYLPELPARGPGADMIGRSLGLLVDLYAHVEPSGWRISDRPGRDTRRARSWLGEDLDALEEFTQGYTGRLKVQAVGPWTLAAALELHGGEAVLQDAGACRDLAASLAEGMRGHLADVQKRVPGAEIVLQYDEPSLTAVLRGRVRSASGYRTYRAVDRQVVESALRDLFSVHDGEVVVHSCAPDVPFALLRRAGAAAVSFDFSLLTEREDDAIGEAVEGGMKLFAGVVPGTDGPLSDPGGSVMGVRKLWRRLGLAPGTLAESVVVTPSCGLAGASPAYARAVQAHCVRAARSLADNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5S0</accession>
    <name>A0A0F4J5S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949605.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29113">
        <property type="protein sequence ID" value="KJY29113"/>
        <property type="gene ID" value="VR44_23695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.685"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="24120" checksum="97F93A74A1E41188" modified="2015-06-24" version="1">MGIERPGRPEDLPAAELLWARWALAAVLEAGEEGERTPRVHRTGTWIDEEGLHLDDCGCTWWTLAPMGRGRYVLYGEDESSAVKWHEPTIDMLAQAPDWLPFQRLRGLLEGWELGCVYWYEDGAWARAPYPDGLADDGLDCGMSRFAVREKALDLLVYADRGVPRERALGLLAAAEAHRLGAREIEAVLADCADDHTAADREAVLRALERSGLSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J618</accession>
    <name>A0A0F4J618_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949539.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29279">
        <property type="protein sequence ID" value="KJY29279"/>
        <property type="gene ID" value="VR44_23375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.615"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470186" evidence="1">
        <location>
            <begin position="35"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="19153" checksum="82F10A7833FB39F7" modified="2015-06-24" version="1">MSAKRVSTRRTRTALAVTALGATLALGAGTTAFADEAPSTAVQAAAAKTSLWEKPVASYTLSATFGKGGSMWAHKHSGQDFAVPVGTPVHAASAGTVVKAGPNGGGDGPAYGNAIVIKHADNTYSQYAHLSKILVKVGQKVALDQKIALSGNTGNSSGPHLHFEIRTTPNYGSAIDPVAFLRKAGITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J676</accession>
    <name>A0A0F4J676_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">VR44_22265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene481"/>
    <dbReference type="EnsemblBacteria" id="KJY29700">
        <property type="protein sequence ID" value="KJY29700"/>
        <property type="gene ID" value="VR44_22265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.339"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="100"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="40240" checksum="639EC94A20606F8B" modified="2015-06-24" version="1">MVGGGQLARMTHEAGIPLGIRFKILSDTPQDSAALVVNDVVIGDYRDLDTLRAFARGCDVITFDHEHVPTEHLRALESDGIPVRPGPDALVHAQDKGVMRAKLDEIGAPSPRHRIVSDPADAAAFAEEVGGFPVILKTVRGGYDGKGVWFVRTPEDAEAPFKAGVPVLAEEKVDYVRELAANIVRSPHGQAVAYPVVESIQVDGVCDTVIAPAPNLSEALAGEAQALALHIAKELDVTGHLAVELFETTDGRILVNELAMRPHNSGHWTQDGAVTSQFANHVRAVLDLPLGDPRPRARWTVMANVLGGDYPDMYAAYLHCMAHDPQVKIHMYGKDVKHGRKVGHVNTYGDDLDDVLERARHAAGYLRGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6X2</accession>
    <name>A0A0F4J6X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949212.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000603.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29935">
        <property type="protein sequence ID" value="KJY29935"/>
        <property type="gene ID" value="VR44_21600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.197"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="15945" checksum="0D231CCD41AB7314" modified="2015-06-24" version="1">MNSTPEERLAAAGLKLPPVAPPVAVYVPAVVSGHYVYTSGQLPMVDGALLRTGKVGGEVTPEQGAELARQCALNALAAVASVAGDLSAVKRVVKVVGFVASTPDFTGQPGVVNGASELLGTAFGDAGIHARSAVGVAVLPLDAPVEVELTVELHTPMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Z6</accession>
    <name>A0A0F4J6Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949204.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29960">
        <property type="protein sequence ID" value="KJY29960"/>
        <property type="gene ID" value="VR44_21555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.189"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6344" checksum="623B608595B949AB" modified="2015-06-24" version="1">MAITISFVALFGLVLFFLLRSRSLGPGSAFVAAGFGFFLASTGAAGPINEMATAIVHAIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J771</accession>
    <name>A0A0F4J771_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000629">
        <property type="protein sequence ID" value="KJY29618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949376.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000629.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29618">
        <property type="protein sequence ID" value="KJY29618"/>
        <property type="gene ID" value="VR44_22470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.383"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="18958" checksum="C234B0A29D1019E8" modified="2015-06-24" version="1">MTGVRKGLAKVEISLRWDPSPAGTPPHDLDLVAGVFGAGDPYGQSVYLVHFGSRAPDGTITLDRDSRNGQGFGWDEVMTLELDRLAPELVRVVVGVVIQDPGPAGTPGRTVFSAVAGTGLRIREGHTDLATGDFAGLAGATAATVAEFLRDGEGGWTLDARTHGFDADPQEYTRLMGAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7X5</accession>
    <name>A0A0F4J7X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948974.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30477">
        <property type="protein sequence ID" value="KJY30477"/>
        <property type="gene ID" value="VR44_20320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8773"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470682" evidence="1">
        <location>
            <begin position="35"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="77"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="58240" checksum="93FBA5CDA19D46BB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8D1</accession>
    <name>A0A0F4J8D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30445">
        <property type="protein sequence ID" value="KJY30445"/>
        <property type="gene ID" value="VR44_20480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8807"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="31500" checksum="6AE3D96B4792E2D0" modified="2015-06-24" version="1">MPQPPTNRSPATPPARPDASMSLLTHVMDHSLDEGYAEASARREAEGTAGLPRTLKAKLALAAGLVLAALVVTLGAAQARATAPVLAKERQELIDRVERADRHADTLERDIERLRTDVADRQREALKQQGGRQAQLVALLSGATEVHGPGVKLVVDDAKGSSSGGGGGPRESAGFSDTGRVRDRDMQRIVNGLWQSGAEAVSINGQRLTALSAIRAAGDAILVDNRPLVPPYEVLAIGDKKRLGTAFQDSVDGQYLHVLQESYGIRYSLSPVDEAKLPAASSLTVRTATAEEPKKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8P8</accession>
    <name>A0A0F4J8P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000653">
        <property type="protein sequence ID" value="KJY29331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949513.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000653.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29331">
        <property type="protein sequence ID" value="KJY29331"/>
        <property type="gene ID" value="VR44_23215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.583"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19250" checksum="4AB150967B3687CF" modified="2015-06-24" version="1" fragment="single">MTNPSVEPVRIANPVRLDELIEAIKNSHADTLEQLSGAVVAAEHLGEVADHLIGHFVDQARRSGASWTDIGRSMGVTRQAAQKRFVPKADKEGDAALDPEAGFSRFTPRARNVVVASQNEARAANNAEIRTEHLALGLLAEPEGLAGLVLASHGITPEALRSAATATLPPAAEEMPALVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J965</accession>
    <name>A0A0F4J965_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000639">
        <property type="protein sequence ID" value="KJY29491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949440.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000639.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29491">
        <property type="protein sequence ID" value="KJY29491"/>
        <property type="gene ID" value="VR44_22805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.493"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="27886" checksum="64C154C32097960B" modified="2015-06-24" version="1">MWAAGEAYEPYVGRWSRLVAARFVRALDVPPGGSWRDVGCGTGAVTRAVLEAAQPADVVGVDPSESYLAYARAHVHDPRARFVRADAVNLPFAGGAASAAVGGLVLNFVPAAPRAAAEMVRVVRPGGLVGVYLWDYGEGGMEAIRAFWDAATALDPRARELDEAVRFPLCTRTALGALLAGAGLVDVETEEIRVPTPFHDFDDYWTPFLGGQGPAPAYLAALPEDRRRALRERLEAALPRAADGSIPLRARAWAARGRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDJ6</accession>
    <name>A0A0F4JDJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_17230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000457">
        <property type="protein sequence ID" value="KJY31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948399.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000457.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000078_gene2295"/>
    <dbReference type="EnsemblBacteria" id="KJY31889">
        <property type="protein sequence ID" value="KJY31889"/>
        <property type="gene ID" value="VR44_17230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7979"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="96"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="31514" checksum="7CCBA6E888FC5D73" modified="2015-06-24" version="1">MASTDTTPKATAKTDDLAGLEAGLDALDAVQTHRTPVREVLTKKVLPPVLAVGLVLVVWQVLVSAKVTDETKLPALSAVWDSLTDMWLKGTLLEVVWTSVSRGLLGFLLALAIGTPLGLLVARVKFVRAAIGPILQGLQSLPSVAWVPPAVLWFGLNDAMMYTVILLGAVPSIANGLVSGIDQIPPLFLRAGRTLGATGLRGAWHVVLPAALPGYVAGLKQGWAFSWRSLMAAEIIASSPDLGLGLGQLLENGRNNIDLPGVFLAIVLILVVGIAIDLLIFSPVERWVLRSRGLLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDP3</accession>
    <name>A0A0F4JDP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000411">
        <property type="protein sequence ID" value="KJY32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948152.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000411.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32452">
        <property type="protein sequence ID" value="KJY32452"/>
        <property type="gene ID" value="VR44_15930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7595"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="22662" checksum="68762A8A1F9F7C1D" modified="2015-06-24" version="1">MTTAPARPAPRPSGGRPARLTSRLTDRLLGTALVIAACDPSAALHASPPVRLLVTAAAAAAAWWAAPMVDARPVHTSMRWPAVLARRRTTVLPAAAIAIAAATDPAPWLVVCIAALLLAYLLVTDPWTAGVTAPPGRPRATPALAAAAATAVVLLAAQAPTARTAYARLPAALAVGATAACLALALHTRHRPPNRPPRPDPAADEARNRPPHRARTRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDR7</accession>
    <name>A0A0F4JDR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000516">
        <property type="protein sequence ID" value="KJY31116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948706.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000516.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4112"/>
    <dbReference type="EnsemblBacteria" id="KJY31116">
        <property type="protein sequence ID" value="KJY31116"/>
        <property type="gene ID" value="VR44_18860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="43381" checksum="17752A6553F476FA" modified="2015-06-24" version="1">MPSPYRAIFAAPGTKAFSAAGLIGRLPISMVGVGILTMISEITGRYAMASALTGTLALAAAMIGPQVSRLVDQYGQRRVLRPATLVSVASVTALVLAAANGLPDWTLFVFAAVAGCVPSVGSMVRARWTELYRDAPRELHTAYSFESVIDEVCFIFGPILAIGLSTTWFPEAGPVIAAGFLLVGVWLLTAQRATEPPPHPRSQDGDRSSALRSPGLQVLTATFVATGAIFGSIDVSTLAFAEEQGHKSAASFILAIWAAGSCLAGIVFGLLHLKGRMERRWVLGICAMAVSMIPLLLAGNLPFLAVALFVSGLAIAPTMITTMALIEAHVPRAKLTEGMTWISTGLAVGVAVGSSVTGLVIDAAGAQRGYVVSISSGVAAAAVAFAGYRRLTRPAQGEEPSRDGDIGDSSGERADRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDX7</accession>
    <name>A0A0F4JDX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic ring-opening dioxygenase LigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31191">
        <property type="protein sequence ID" value="KJY31191"/>
        <property type="gene ID" value="VR44_18630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8335"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="67"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="32226" checksum="E2E515090A8D4F2F" modified="2015-06-24" version="1">MSGLLPALAVPAAPVYGALLSYLVYHPPRRPHHKHPRDFGLPLEEVAVPLPGGGRTLHVWLCRGGTDRVVVIGHGIGLSKSASLAQAAFLHEAGYTVALFDHRNHGLSDSDKAFWGLSERHTDDVVAVVDHLRGSDGYQDARFAVFGFSFSTFPSLYLLRRPDRPVDAIVCDSGPALELEPLFRNFLRAKGLPVPRPLRSGPSWAVLTAVFSRLGTAMLRAQWPPPAEGAYLDTPVLILAGEDDSIIPVEGARALAARYPRAEIEVLPGTEHLQGMKTDPDRYRTAVLDFLKRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE55</accession>
    <name>A0A0F4JE55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948327.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32023">
        <property type="protein sequence ID" value="KJY32023"/>
        <property type="gene ID" value="VR44_16840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7803"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="246" mass="25442" checksum="01C62C7195BDB4E8" modified="2015-06-24" version="1">MPYVAVTALSHAGLVRERNEDSLVVGPWTLCATVTDSPQTLVFPLGRPLLVAVADGLGGHPAGEVASALVARRLSALGPTLDGPDTLRDALDVCDYEVDAAAEGHPEMFAMATTVAGVLVLAESLLVFNVGDSRVYSAGPDGLRRVSVDDSPPPPPGRRTTSAVTQTLGGSRASGTPVPHVRALALAPGDRYLVCSDGLTDPLPDEEIDAVLKAHDDGRAAFELWKAAIEAGGPDNITLALVRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEW8</accession>
    <name>A0A0F4JEW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32745">
        <property type="protein sequence ID" value="KJY32745"/>
        <property type="gene ID" value="VR44_15250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7386"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="12313" checksum="53810A34A9E85677" modified="2015-06-24" version="1">MSVILTLEAVGDPKALEQYARSHNEKFQGVLETAKRHGLIAHRFYGSEDGTRLMVLDEWPDRQSFESFFQEMESEIRPMMEAAGVTARLEPTFWRELSTQDAYGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFS5</accession>
    <name>A0A0F4JFS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32654">
        <property type="protein sequence ID" value="KJY32654"/>
        <property type="gene ID" value="VR44_15560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7512"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19534" checksum="CAE9F22E594DA17A" modified="2015-06-24" version="1">MLPSTDAIAQLRDAVAAAPPGHGLRWTGEASWHFTLAFMGEVQDDHLPELHARLARAAAHTAPFPLRLHGSGHFGRRALWIGAAGGLDALRMLAERADAAARRAGIPMEQHRRYTPHLTLARARDDAADLRPCLDALSGFEGTPWQVDTLSLVRSHLPVSGVAGEQPRYEVVDAWPLTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFZ1</accession>
    <name>A0A0F4JFZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000399">
        <property type="protein sequence ID" value="KJY32673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32673">
        <property type="protein sequence ID" value="KJY32673"/>
        <property type="gene ID" value="VR44_15480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7497"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25106" checksum="0A3A18541837A5D0" modified="2015-06-24" version="1">MTLWPDTFTDHLAPGTARAATRVLAAAGLTVTVPTAGPVCCALTYVSTGRLTRARRVLRRTLETLGDVEGPVLVLEPSCAAALRTDLPALLPDDPRAHRLAAAVRTFAETLEQYAPHWTPPRLDRPVAGQTHCHQHAVLGDAADRRLRDRAGLTGELSGGCCGLAGNFGFEPGHHAVSVACAEEQLLPSLRSAGPDAAVLADGYSCRTQIAQLSGHRARHLAELLAEALAPDEGPDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGG7</accession>
    <name>A0A0F4JGG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947983.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32909">
        <property type="protein sequence ID" value="KJY32909"/>
        <property type="gene ID" value="VR44_14965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7409"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="91"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="373" mass="40574" checksum="CAE86F472BBC0949" modified="2015-06-24" version="1">MEAASKVGDPKADELVSDLIDNKEVDGVNALFRTIGTLKPGMDLSGLPPRLATFLKEAAAAPPDWSEADVKAAESFFARHHGEVSMLQGTVGLIGTYLSPTGAFTLRSTGRLGGVEGPGRRLSQSSRLFLDMGDKNALRDGSLAANVTKVRLVHASVRQLHKKSGEWDYAKWGEPVSQKYTTGAACVFSTQILQAMKRLGVDVSKDDAKGFVCAWHYVNHYLGTPDKWLLPKDPDQVEALWNQERDKEWKKTDDGVFMTRQAVDFYRKFYPPGVHDAFFAMVRHALSDKYADMAGLPKSVLGAAAEPLAAGHGVVSGIAGGMLGGTAQKATGVNPYKDILGIASKGYNEIQRFALTQGEDDQPQMHQELHDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHH8</accession>
    <name>A0A0F4JHH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_14335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000370">
        <property type="protein sequence ID" value="KJY33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33213">
        <property type="protein sequence ID" value="KJY33213"/>
        <property type="gene ID" value="VR44_14335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7216"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="411" mass="45360" checksum="112A4528073C6B47" modified="2015-06-24" version="1">MRADVPDSLLVAEPLSGKKDSGLRGVGRRVLANLKRARKALLVHIALRATGLAVMAIWAERKDVRPLEILGGRWDAVYYLHIAENGLTTPLATPSPCAFAGPSCQMAFFPVYPMLVRYTSYVTHLPMNWVAMGLALFASVIAAWGIFAVTDKIYGRRVALFTCALFAIVPAALVQSMAYTEPLFLALSVWAMYAVMTKSWLTAGVLAFFAGATRPSGSAIVAAVVLAGVWEYVQWRRGRRAQRPAVGRIVTASLIAPLGWFGYVGYVGWHFGRWDGYFELQRRWGSVYDGGFDTVNELKKTFTEVHTTLNHVVVSLTVVTAVVLFVLMTRRRRPPMVVWIFAAMIMLMALGGAGFYFSKMRFIMPAFPLLFPFALALARARRSTVLWILGSATAVSALFGGNLNFVWWGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHM0</accession>
    <name>A0A0F4JHM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_13110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000333">
        <property type="protein sequence ID" value="KJY33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947640.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000333.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33847">
        <property type="protein sequence ID" value="KJY33847"/>
        <property type="gene ID" value="VR44_13110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6684"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045985">
        <property type="entry name" value="DUF5941"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19365">
        <property type="entry name" value="DUF5941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5941" evidence="3">
        <location>
            <begin position="266"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="591" mass="62035" checksum="85958CCBA3822FA4" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHS3</accession>
    <name>A0A0F4JHS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947693.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2640"/>
    <dbReference type="EnsemblBacteria" id="KJY33755">
        <property type="protein sequence ID" value="KJY33755"/>
        <property type="gene ID" value="VR44_13395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6915"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="20100" checksum="70E887B0F6AD3729" modified="2015-06-24" version="1">MPHVLVLNASYEPLGVVPLRRALVLVLENKAISLEESGAFLHSATQAVPAPSVVRLKRFVRVPYRGPVPLTRRALFARDGGRCMYCGAVATSVDHVIPRSRGGQHVWDNVVAACRRCNHVKADRHLLELGWRLRHQPAPPSGLAWRIIGTGHRDPRWMPYLQPYGADDALERIGVGVTAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHY3</accession>
    <name>A0A0F4JHY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000325">
        <property type="protein sequence ID" value="KJY33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947605.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000325.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33937">
        <property type="protein sequence ID" value="KJY33937"/>
        <property type="gene ID" value="VR44_12920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6701"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="15372" checksum="7E96A9FDFB97FF50" modified="2015-06-24" version="1">MITVIEQAVQARLVATAPKVETVPVTLCYDRSDPFAVRMAFPALATLEGVEVSWTFARELLMSGIQHPAGCGDVRVRPYDGDRTTVEFHAPEGVAIVLMTTAEIQRFLERSRELVPPGLEHRYLDMDHSLDELMRGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI16</accession>
    <name>A0A0F4JI16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000323">
        <property type="protein sequence ID" value="KJY33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947595.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000323.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33977">
        <property type="protein sequence ID" value="KJY33977"/>
        <property type="gene ID" value="VR44_12870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6669"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="39401" checksum="C9A88ADF9F1877F2" modified="2015-06-24" version="1">MDLPVMPPVKPMLAKSVAKIPPGMQYEAKWDGFRAIVHRDGDEVEVGSRTGKSLSRYFPELVAALKENLPARCVVDGEIVIVHGGRLDFDRLTERIHPAASRVKLLAETTPASFVAFDLLALGDDSLLDTPLADRRGALVHVLSTARPPVHLAPATTDPALAREWFERFEGAGLDGVVAKPLDLPYRPDARLMFKIKHERTADVVLAGFRFHKTGPIVGSLLLGLYDGQGALQHVGVCAAFPMKRRAELVEELEPLRMPDAEGHPWASWTDEAAHESARLPGAQSRWTGKKDLSWVPLRPERVCEVKYDHMEGDRFRHTAQFVRWRPDRTPESCTYGQLEEVVGYDLAEVLGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI68</accession>
    <name>A0A0F4JI68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947572.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000318.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene510"/>
    <dbReference type="EnsemblBacteria" id="KJY34037">
        <property type="protein sequence ID" value="KJY34037"/>
        <property type="gene ID" value="VR44_12750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6630"/>
    <dbReference type="eggNOG" id="COG1507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20440" checksum="D7DA171ECCD502FB" modified="2015-06-24" version="1">MQTPPPQTDRTEPTDADIEAFEQQLGRPPRGLRAIAHRCPCGQPDVVETAPRLPDGTPFPTLYYLTCPRAASAIGTLEANGVMKEMQARLAEDPELAAAYQKAHEDYIRRRDAIEVLQGFPSAGGMPDRVKCLHVLVGHSLAAGPGVNPFGDEALAMLPEWWAKGPCVTPCGGKAEEEKAAEEEPKGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI78</accession>
    <name>A0A0F4JI78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947773.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33504">
        <property type="protein sequence ID" value="KJY33504"/>
        <property type="gene ID" value="VR44_13860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7051"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11901" checksum="A59D2D8AA6293CDB" modified="2015-06-24" version="1">MTGGKAVVTTTTEREATVIRLQGEVDEDDTPLLARALGQAAQGGPPRTVVDLSGTPFVDSSVLHALLAAQRAHAARGRVLVLAGPLQTAVRRLLDVTGAAHAFRMADSLATAMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIM3</accession>
    <name>A0A0F4JIM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000307">
        <property type="protein sequence ID" value="KJY34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34197">
        <property type="protein sequence ID" value="KJY34197"/>
        <property type="gene ID" value="VR44_12385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6463"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9197" checksum="0A71BD643AF9D036" modified="2015-06-24" version="1">MDAARRARRAGAKVVALTSYARSPLSEACDCTLVAGGQDLVFGLETVASRLAHLTVVDALTLTLLGLRGAPAEEALRLSADVTVDHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK30</accession>
    <name>A0A0F4JK30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacillolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947519.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34174">
        <property type="protein sequence ID" value="KJY34174"/>
        <property type="gene ID" value="VR44_12475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6555"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470812" evidence="1">
        <location>
            <begin position="29"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="37285" checksum="FD298C432D167BFC" modified="2015-06-24" version="1">MARRISRGLVAAATATVATLALAGPVAAQSAGTATTGSALPQGRIFMVNPVQSSGDQSLTDGKDGNAAVPASAYALAALHNLDGSGGLSGKWAAVRSETGAPARLADAASYSRKDDGFEQVMAYFWVNEAQEYLQSLGFGSELPGANDRVQPIRINQWGADNSFFSDTKAEIRFGKGGVDDAEDAEVIVHEYGHAVHNAQVPGFGTSPEAGAIGEAFGDFLAVSVGAYADETHGWPRKTDLACVGDWDSVEYSAAPHCLRRVDGNKVYADRVGEVHADGEIWSRALFDIRGALGARTAGRIIVNAQFVVNAQFGFRPDTSFQDAALTTIDTAQRMYGADAAAAVRAAFKARQIPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKM3</accession>
    <name>A0A0F4JKM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947331.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34740">
        <property type="protein sequence ID" value="KJY34740"/>
        <property type="gene ID" value="VR44_11455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6189"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="33357" checksum="D720D1FA7C9BC08B" modified="2015-06-24" version="1">MRVVIALGGNALLHRTERPDAAIQLANVHRAVDALAPLAEQHELVITHGNGPQVGVLALQSAADRSLSGPYPFDVLGAETQGMIGYWLLQSLQNALPARQVCALLNQTLVSAADPAFAGPEKFVGPVYGRAEAESLAAERGWTVKQDGEHWRRVVPSPRPQRVVETRLIRLLLDSGTVAVCAGGGGVPVVRDEQGRLAGVEAVVDKDLTAAVLAEALDADFLLLLTDVPYVELGHGTPKAEPVRHTTPARLRAHRFPAGSMGPKVEAVCRFVELTGGTAAIGALEDARAILDGAAGTVVSPSGRAPQDGALTHQEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLE0</accession>
    <name>A0A0F4JLE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947199.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35162">
        <property type="protein sequence ID" value="KJY35162"/>
        <property type="gene ID" value="VR44_10710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5889"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27512" checksum="74859E9B27327CC8" modified="2015-06-24" version="1">MVNTPSKSLSGKVAFVGGASRNLGGLISTTIGAEGAKVAVHYNSASSKAKAEDVVAQINAGPGEAFAFQADLTRVDEVERVFDEVVSRFGKLDISVNTAGMVLKKPLTQITEEEYDRMFAVNSKAAFFVMREAARRMEDGGKIITIVTSLLAAYTGLYSSYAGSKAPVEHFTRALSKELFGRNISVNNIAPGPMDTSFFYPAEDEDSIAYHKSSAMNGDLTKIEDIVPWVRHLLTDGWWANGQTFFVNGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLE8</accession>
    <name>A0A0F4JLE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000274">
        <property type="protein sequence ID" value="KJY34644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947352.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000274.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34644">
        <property type="protein sequence ID" value="KJY34644"/>
        <property type="gene ID" value="VR44_11565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6222"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11180" checksum="AC7C7B86F4F91FAB" modified="2015-06-24" version="1">MIATYGFNATLTARPGMGDRLVDLLLTGLQEGNPGASEYCVVYLVSRCTSAPDVVHVTEGWTSEEDHHRIFAGEAAQAIVAQVGGLLAKESEYTDYVPVCGKAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JME7</accession>
    <name>A0A0F4JME7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMNH2-utilizing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947536.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34121">
        <property type="protein sequence ID" value="KJY34121"/>
        <property type="gene ID" value="VR44_12545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6570"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="39715" checksum="89B5EBD28957606E" modified="2015-06-24" version="1">MSELHLAVALDGAGWHPAAWREPGARPAELFTARYWADVVAEAEAGLLDFVTFEDALALQSSSATAPDERTDQVRGRLDAVLTAARVAPLTRNIGLVPSVTATHTEPFHVSKAIATLDYVSRGRAGLRVQTSTLPHEAAHFGRRTFPVPVGEPAAEAADHVEVVRRLWDSWEDDAEIRDVATGRFLDRAKLHHIDFTGPYFSVRGPSITPRPPQGQPLVTASAGAVAPGGGSVDLVYVTPRDQEEARAAADSARSPHVFADLTVFLDGDGPAAATRRERLDALAGQPAPTDAAVFTGTPAGLADLLLRWRAEGLTGFRLRPAVLAHDLPLITRGLVPELQRRGAFRTAYGAPSLRGLLGLDRPASRYAATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN85</accession>
    <name>A0A0F4JN85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000232">
        <property type="protein sequence ID" value="KJY35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947142.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35294">
        <property type="protein sequence ID" value="KJY35294"/>
        <property type="gene ID" value="VR44_10435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5829"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="70"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19804" checksum="28D0612B17E124F4" modified="2015-06-24" version="1">MAKTKRRGRLWAGLLAAAVLALGLGVYWFQPWKLWQDSTVREALPTTSGKAAQPGPGSSAVPPGAPTGPQTLARGTLISHEHTTTGTVALIRLPDGSRTLRLEDLDTSNGPDLRVWLTDAPVKEGVAGWTVFDDGKHVSLGRLKGNKGDQNYQIPADVNLADYRSVTIWCDRFDVSFGAASLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNG4</accession>
    <name>A0A0F4JNG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000232">
        <property type="protein sequence ID" value="KJY35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947144.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35298">
        <property type="protein sequence ID" value="KJY35298"/>
        <property type="gene ID" value="VR44_10450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5832"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16696" checksum="74C3D7A6BEB5F36C" modified="2015-06-24" version="1">MKVIIVCVSVSHGNTRRVADSIGQVLGARVVSPEEADPTELSGADLVGFGSGVFYSRLHPRLTDFVKALPNGRGRAFVFATSGLPEVPPAPFTRPLVRLLEGKGFEVEGSFSCRAFDTWTPFKLVGGINKRRPNGEDLAAAQAFAERLRDGRGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNL1</accession>
    <name>A0A0F4JNL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxydechloroatrazine ethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947380.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3718"/>
    <dbReference type="EnsemblBacteria" id="KJY34511">
        <property type="protein sequence ID" value="KJY34511"/>
        <property type="gene ID" value="VR44_11725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6312"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="68"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="467" mass="49768" checksum="B45FEB237B02BD92" modified="2015-06-24" version="1">MAASAAHDGAVERIVIENCAIATVDANDTEYASGHVVIAGNKIEFVGAGKAPENLDNVVRRIDGTGHLVTPGLVNTHHHFYQWITRGLATDHNLFNWLVALYPTWARIDEQMAYSAAQGSLAAMARGGVTTAMDHHYVYPKNSGDLSGAIIRAASEMGVRFTLARGSMDRSEKDGGLPPDHAVETLEGALADTEATIKKYHDASFDAMTQVAVAPCSPFSVSTELLKQGAELARRLGVRMHTHGSETVEEEKFCHELFGMGPTDYFESTGWLGEDVWMAHSVHMNDSDIAAFARTKTGVAHCPSSNARLAAGIARVPDMLAAGVPVGLGVDGTASNESGELHTELRNALLINRLNPVHREAALNARQSLRLGTYGGAQVLGRADNIGSLEVGKCADLVLWNLNTFLHSSIADPVTALVFGAAAPVTASFVNGKQIVENNRLLFADEDAIAVSTRAEAQRLARISAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNV2</accession>
    <name>A0A0F4JNV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946873.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35885">
        <property type="protein sequence ID" value="KJY35885"/>
        <property type="gene ID" value="VR44_08975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4967"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="3">
        <location>
            <begin position="417"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="489" mass="52693" checksum="3FB07FC19E095928" modified="2015-06-24" version="1">MDQSRAPVLDALAAYHEAGQTPFTPPGHKQGRGADPRVRAVLGDSVFRSDVLATSGLDDRTSSHGIVEEAQALMAEAVGAEHAFFSTCGSSLSVKSAMLSVAGPHEELVVGRDAHKSVVAGLILSGIRPVWVDPQWDPERHLAHPPSPQAFEEALAGHPDARGALVTTPTPYGTCSDLAAIAEVCHRRGVPLIVDEAWGAHLPFHPDLPTWAMDAGADVCVTSVHKMGSGLEQSSVFHLQGDLVAPEVLKGREDLLGTTSPSVLVYAALDGWRRQMVQYGKTLYDDALALAGRVRDRISRIDGMHVDDRDDFCGPGKASDLDPLQVIVDISACQVTGYRAADWLRRHHRINLHVSDHRRISAQLTHADDDRTAGILLAALTDFAAHAPQLRTGQPVYVPPPSGLRLEQAVLPRDAFFGRTEQVPWERAEGRVAAEMLTPYPPGIPAALPGERLTMDVLRYLRTGVEAGMVVPDAVDTDVTGVRVLREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP16</accession>
    <name>A0A0F4JP16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Drug:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946772.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene926"/>
    <dbReference type="EnsemblBacteria" id="KJY36112">
        <property type="protein sequence ID" value="KJY36112"/>
        <property type="gene ID" value="VR44_08450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4753"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="47064" checksum="67BCAF434424A6E8" modified="2015-06-24" version="1">MTEPTEPLSEHRADVIVVGAGPAGSTTAYYLAKAGLDVLLLEKTAFPREKVCGDGLTPRATKQLVAMGIDISEEAGWLRNKGLRIIGGGQRLQLDWPELASYPDYGLVRKRDDFDETLARQAQKAGARLYERCNVGEPVRDPRTGHITGVHAKLGEEKTPVTFHAPLVVAADGNSSRLSLAMGLHRREDRPMGVAVRTYFTSPRHDDDYLESWLELWDRRGPQDRLLPGYGWIFGMGDGTSNVGLGILNSSSAFKELDWREVLKAWCASMPEDWGYTPENMTQPIRGAALPMAFNRQPHYTKGLLLVGDAGGLVNPFNGEGIAYAMESGQIAAEVIVQAHARATPAQRELALHSYPKVLKETYGGYYTLGRAFVKLIGNPTVMKIAAQRGLTHPVLMRFTLKMLANLTDPTGGDAMDRIINGLSKVAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPA5</accession>
    <name>A0A0F4JPA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_09910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947044.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000213.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35583">
        <property type="protein sequence ID" value="KJY35583"/>
        <property type="gene ID" value="VR44_09910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470914" evidence="10">
        <location>
            <begin position="29"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="11">
        <location>
            <begin position="52"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="331" mass="34067" checksum="EA797B2BD5C58DA2" modified="2015-06-24" version="1" fragment="single">MHGMRMWKATSALVGLLLAGVAATPAHAQTIREQQWHLDAMKADDIWKISTGEGVTVAVIDGGVGRIPELEGQVLPGKDFAAGQTGYEGDERNDYNKHGTGIAAVIAGSGKHPSGDGAYGLAPGAKILPIRVPLDLSPSTPTWVSAIRYAADSNAKIINISLGVEGSAKDDLARSEAVKYALSKGKLIFAAVGNDGNTTNWVEYPGATPGVVGVGSVGPDGGAAKQSQHGPQVDLSAPGVDIVTACAGKTELCKSSGTSDATALTSASAALLWSVHPTWTNNQILRVLLNTAGKPVDGVERNDYIGYGVVRPRVALPTPGDPGPPDVYPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPB1</accession>
    <name>A0A0F4JPB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyaluronate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947300.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34771">
        <property type="protein sequence ID" value="KJY34771"/>
        <property type="gene ID" value="VR44_11285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6150"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="42456" checksum="5767539C536E7CDD" modified="2015-06-24" version="1">MSTEKSADDPQQVWDVVVVGAGPAGASAAHAAAAAGRHVLILEKARLPRYKTCGGGIIGLSRDALPPGFELRLRDRVHAVTFTRNGRFPRTRRSRKTLFGLVNRSEFDQQLVEHARQAGAEVRTGAAVARVEQHQPDEGTAQLVLQGGETVLARAIVGADGSAGRVGAHVGVTLDQVDLGLEAEIPVPAKVAAHWAGRVLIDWGPLPGSYGWVFPKGDTLTVGVISRRGEGAATKQYFEDFVVRLGLADYEPSISSGHLTRCRSDDSPLFRSRVLVCGDAAGLLEPWTREGISFALRSGRLAGERAARIAQARDTADVHRQALDYANAVTTGLGAEMTVGRRVFDFLQRHTGLSYMAVTRIRPVWNLLAKTTRGSTPLSEALHAHPAGRALRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPG0</accession>
    <name>A0A0F4JPG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947003.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35638">
        <property type="protein sequence ID" value="KJY35638"/>
        <property type="gene ID" value="VR44_09695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5387"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27068" checksum="3C49FF1F8FB9E593" modified="2015-06-24" version="1">MSIAELQVYSVEEADVTGGVCLVRCVGGTARSGQVYAAGESRVWLRGAERHGQAVDSFGAGHTARVRLAGAVVALLIRGQVLTSVPPDGHGLAELEAWLDTGPPLTDEPRPRTLRSLAIGGMQNERLPDGTRLRWGRVALAAAHRCAAAEGASDLLRGIELASVRAYLLREFGPGPGGDPAALGREALALIDLTPAEAAARARDWRALPRERILHLRRIKNLLRWAGAARPYLAPGDPLAQALETWSQVGRQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQK1</accession>
    <name>A0A0F4JQK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946699.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36455">
        <property type="protein sequence ID" value="KJY36455"/>
        <property type="gene ID" value="VR44_07960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4414"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="25931" checksum="F8FDBE1864E6D6E7" modified="2015-06-24" version="1">MSVDRGCGSEVSVPRRRLVRAGLRGAAVLGAGLVCGASAASGSRSGAAVGDRPRPCEPGRAWRELEAGNRRWRTFRESHPDQAGDVRRALVGGQHPFAVVLGCVDSRVPPELVFDQGLGDLLTVRSAGEVLDEAVLGSISYGVLELGVPLIVVLGHQGCGAVAAAVHAEAGGALPAHVRYLAERIRPAIDHRLEGQARIDAAVTENVRRVRARLTAEPDLAARVADGCLAIVGARYELTSQLVRKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQQ3</accession>
    <name>A0A0F4JQQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2252"/>
    <dbReference type="EnsemblBacteria" id="KJY36692">
        <property type="protein sequence ID" value="KJY36692"/>
        <property type="gene ID" value="VR44_07450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3964"/>
    <dbReference type="eggNOG" id="COG3263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="386"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="50485" checksum="0C901FE6886BF7B3" modified="2015-06-24" version="1">MLLVAVAAVRISSRSGLPSLLIYLGIGIAIGQDGIGNVVFDNAELTQVIGYAALVVILAEGGLGTKWKEIKPALPHAVALSLVGVAISVGVTAAGAHYLVGLEWRQSLLIGAVVSSTDAAAVFSVLRKVPLPSRVTGVLEAESGFNDAPVVILVVAFATVGPVDPWYVLVGKIALELAIGAAIGLAVGFLGAYGLRHVALPASGLYPIAVMAIAVSAYAAGAMAHGSGFLAVYLAAMVLGNAKLPHWPATRGFADGLGWIAQIGMFVLLGLLVTPHELAKDFWPAVIIGLVLTMVARPLEVFVSLLPFRVAWQEQVLMSWAGLRGAVPIILATIPMVTGIEGSDRVFNIVFVLVVVYTLVQGPTLPWLARKLNLRETGEAAADLGIESAPLEKLRGHLLSFAIPEASRMHGVEVGELRLPAGASVTLVVRDAKSFVPAPSTVLRRGDELLVVATDPVRDAAEARLRAVARGGKLAGWLGTSGGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQR3</accession>
    <name>A0A0F4JQR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946794.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36088">
        <property type="protein sequence ID" value="KJY36088"/>
        <property type="gene ID" value="VR44_08560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4854"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="238"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="45618" checksum="A6B5B7C4F228BA31" modified="2015-06-24" version="1">MAEVRDVVWAPVAGRTWRGLLYLVVGLPLSCVYFGLAIAGLATGAGLLVTFVGVPVLAGVLAMCRGFGIVERARVRGLLRVPVRDPAPVRAGKPGVPAALGALLKSGSAWRHVLYSVIHFPWALFAFCLALTLWGYGWSMLLYPLWFWVFPAFTDQPGLQLFQNGDYTFYLDSPLTIAAASALGLVFTLTAPWVVRGLVAVDRVLVTGLLGRSRLDDRVSELESGRGVVVDTAAADLRRIERELHDGAQARLAALAMDLGLAKEKLAEDPRAAARMVDEAHGEVKVALRELRDLARGIHPAVLTDRGLDAALSAVAARCAVPVRVEVDLPARPAPAIEGIAYFTVSELLRNVRGHAGARSAGVDVWRSGQRLMIRVADDGHGGDAASGGTALPAGLAERLDAMDGVLVVDSAEGRGTVVTAELPWRDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRE9</accession>
    <name>A0A0F4JRE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_06915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="JZWV01000128">
        <property type="protein sequence ID" value="KJY36922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946490.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000128.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2773"/>
    <dbReference type="EnsemblBacteria" id="KJY36922">
        <property type="protein sequence ID" value="KJY36922"/>
        <property type="gene ID" value="VR44_06915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3467"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="443"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY36922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="488" mass="53253" checksum="8F9AD9FCBD186B62" modified="2015-06-24" version="1">MGALSHDRARDPATRPLTATRTFPSGFLWGTATAAYQIEGAAREDGRTPSIWDTFSHTPGKVFAGHTGDVAVDHYHRFAEDVRLMSELGLGAYRFSVSWSRVQPAGRGPAGRKGLDFYRRLVDELLAAGIEPALTLYHWDLPQDLEDAGGWPERGTAERFAEYAGLVADALGDRVKRWTTLNEPWCSAFLGYGSGVHAPGRTDPVAALRAAHHLNLGHGLAVQALRASLPGDAQLAVSLNLHAVRPLTPRAEDREAARRIDAVGNRIWLGPMLEGAYPQDLFADTSHLTDWSFVRDGDTATIHQPLDLLAVNYYTPTVVSRVAEGAERPQDDGHGDSEHSPWPGADGVAFHRAPGERTAMGWPVDPDALYDLLTGTAARYPGLPLVVSENGAAYEDEVGPDGTVHDPRRAAYVHAHLEAVHRAITDGADVRGYFLWSLLDNFEWAYGYAKRFGAVHVDYGTLERTPKSSAHWYSRVARTGRLHAPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRJ5</accession>
    <name>A0A0F4JRJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946460.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36972">
        <property type="protein sequence ID" value="KJY36972"/>
        <property type="gene ID" value="VR44_06745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3428"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17380" checksum="49A68856E1E830F1" modified="2015-06-24" version="1">MSADLTPVIAAGTRWLLTAFPPAPGAFSRALAEAQARQAVTLAAGLRYPTALDAELVLLLGPGGSARLDWLTGAEPDGEDDAWRSWVDETLVSWAACLLADASLAAGAQRVADRALAGGLTRLVRPGEHEHHAAPLLRHPDLVEPVAALHRAPLLELLENQGAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRQ5</accession>
    <name>A0A0F4JRQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_06670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000123">
        <property type="protein sequence ID" value="KJY37042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946447.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000123.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37042">
        <property type="protein sequence ID" value="KJY37042"/>
        <property type="gene ID" value="VR44_06670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3252"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="35778" checksum="DC8FEE430D065424" modified="2015-06-24" version="1">MNATAPTTAETLRSALGGLLDGLPPKQAAAAVERLIANYRGTTPTDAPVLRDRSDVAAYAAYRMPATFEAVRSALDGLAEAAPRWVPGSHVDVGGGTGAATWAVDAVWDGPRTTTVLDWAEPALALGKELAARSGSDALRTADWRRAVIGAGIALPDADLVTVSYVLGELTAEARRAVVAEAARAGQAVVLIEPGTPQGYLRIREARDQLIAAGLKVAAPCPHDGACPIEVGQDWCHFSARVSRSSLHRKVKGGSLPYEDEKFSYVAATRFPTTPVPSRITRRPQIRKGLVLLDLCGPEETGLGRATVTKRHGGLYKAARDAEWGEQWPPADAPDSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS9</accession>
    <name>A0A0F4JRS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">VR44_09550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946976.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35651">
        <property type="protein sequence ID" value="KJY35651"/>
        <property type="gene ID" value="VR44_09550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5311"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="24836" checksum="CDB1DE90CA6450CA" modified="2015-06-24" version="1">MSDVKDLVQVAGIIDAEEAKLLAEEGVDWFGFPLRLPSGKDDISEAAATEIIAGLTAPQEGVLISYMVDADEISEFTTQLGVKAVQLHGDVTPEELRKLKAIRPDLYVLKSLVVKEDNAEELLQFVDEVAEFVDMFITDTFNPATGAKGATGLTHDWNVSAELVRRSPKPLMMAGGLSPENVADAIRFVKPAAVDAHSLLEGEDRRKDRAKVAKFVAESRKAFAEIANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTS4</accession>
    <name>A0A0F4JTS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37148">
        <property type="protein sequence ID" value="KJY37148"/>
        <property type="gene ID" value="VR44_06400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3191"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="413" mass="44688" checksum="67824AEB1E86CF18" modified="2015-06-24" version="1">MKPPLQLTRTHKILIGTVTFGAVVVAGIGFAGSYAAVQKLALRKGFGSFAYVFPVGIDAGIGVLLALDLLLCWIRIPFPVLRHIAWLLTAATIAFNGAAAWPDPLGVGMHAVIPVLFVITVEAARHAVGRIADITADKDMDGVRITRWLLAPAPTFKLWRRMKLWELRSYEQAVGMEQDRLVYRTRLQARYGRAWRRKAPVEAVIPLRLAKLGVPLAQTAPAGLAAAGILIEWRPSAPSAPAFEEHAETALDLAATPALPPIRTVIPSPAVAFAADKPKRPREEVSIRIPPDDANGLDDCEADTQEEDTQEPEPENLHDDPADTQDPQAGDAADESTNPQDAPACPPPDNSLTARNARAAKEAAKRRLSYAEGWQQAQQDTPGITQAQFAERLGISPRTLRRALTENTPALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU43</accession>
    <name>A0A0F4JU43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol3_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946289.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000108.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2554"/>
    <dbReference type="EnsemblBacteria" id="KJY37354">
        <property type="protein sequence ID" value="KJY37354"/>
        <property type="gene ID" value="VR44_05855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1987"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="35426" checksum="08266627DFFCDD03" modified="2015-06-24" version="1">MLEPMATRKNPTDEPLAPITLAVGQEDLLLDRVVRDVVKAARAADADTDVRDLTSDQLQPGTLAELTSPSLFSERKVLIVRNAQDLGADTVKEVKAYLADPYEEITLVLLHAGGVKGKAVLDAARKAGAREIACPKMTKAADRLSFARQEFRTLGRSATPEACQNLVDAIGSDLRELASAVAQLCADVEGTIDEAVVGRYYTGRAEASSFTVADRAVEGRAAEALEALRWSLATGVAPVLITSALAQAVRAIGKLASAPRGARPGDLARDLGMPPWKIDRVRQQMRGWSADGVSEALRAIALADAGVKGGGDDPEYALEKAVVAVARAARPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUD7</accession>
    <name>A0A0F4JUD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946255.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2521"/>
    <dbReference type="EnsemblBacteria" id="KJY37424">
        <property type="protein sequence ID" value="KJY37424"/>
        <property type="gene ID" value="VR44_05665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1948"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15158" checksum="B520594E3836E555" modified="2015-06-24" version="1">MATAPGETNTAPVRGRSTRQRAAVAAALDEVDEFRSAQELHDMLKHRGDSVGLTTVYRTLQSLADAGEVDVLRTSDGESVYRRCSTGDHHHHLVCRKCGKAVEVEGPAVEKWAEAVAAEHGYVNVAHTVEIFGTCADCAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUI6</accession>
    <name>A0A0F4JUI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/prolyl-tRNA synthetase associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946605.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36641">
        <property type="protein sequence ID" value="KJY36641"/>
        <property type="gene ID" value="VR44_07585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3994"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16865" checksum="6D24F664D70207CA" modified="2015-06-24" version="1">MTTSTPHPLFAQALAELGLDLPIRTFPEGTRTAADAAAAIGCELSQIVKSLIFTADGVPVLVLMDGASRVDVEAVRRQLDAAKVTRADATVVRETTGYAIGGVPPFGHRTRTRVLADQALLRHDVVWAAAGTPHAVFPMPPRELVTHAAAELADVREKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUR1</accession>
    <name>A0A0F4JUR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38097">
        <property type="protein sequence ID" value="KJY38097"/>
        <property type="gene ID" value="VR44_04150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.119"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28998" checksum="ED912B29B0D629F6" modified="2015-06-24" version="1">MDRMPNPTEPIETPSRAQLIDHLVSTRIAGQVATPRENNLSHYRKLANGDRHYWLGLELGDRWADEQDVLAVMAERVGVVDDPAHRTGQDTIDPELTVAGLDRMAARLRKAALDRQSVLFATGHPGGLLDVHRATAEALRAAGCEIVRIPAGLFADEGSVWQFADVAVLERGATLWHTHSPAPMAAILDALTADGRPQPDLVVADHGWAGCAAQRGLDAVGYADCNDPALFLAEAEGTLQVAVPLDDHVRDPRFYDPMVAYLLAAAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWJ6</accession>
    <name>A0A0F4JWJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945776.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38747">
        <property type="protein sequence ID" value="KJY38747"/>
        <property type="gene ID" value="VR44_02965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7325"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="28782" checksum="3BF3E8BA8955FC2E" modified="2015-06-24" version="1">MESLRAVENWPVPAAAAAVVRADGSLAGSHGPVDRRFPLASVTKPLAAYAVLVAYEEGAVELDEPAGPEGSTVRHLLAHTSGLAFDEHRATAPPGQRRLYSNAGFEVLGDHLAKATGIPFADYLREAVFEPLGMNSSSLEGSPAKDGVSTVSDLVRFAAELQAPRLLDVRTVAEATSVVHPGLKGVLPGYGHQSPNDWGLGLEIRDGKSPHWTGLTSSPRTFGHFGQSGTFLWVDPDVRAACVALTDRAFGPWAVEAWTPFTDAVLAELRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWX3</accession>
    <name>A0A0F4JWX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945952.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38248">
        <property type="protein sequence ID" value="KJY38248"/>
        <property type="gene ID" value="VR44_03905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8685"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="23497" checksum="9CBB6FF85DBB25F5" modified="2015-06-24" version="1">MGFTIGGSRGTKEFRSGVRRRGRTSECTAVAEYTGLWGWDAVPGARAAAPARDCSCGHTNCPTPGAHPLDFAPTVPGGATLDEVTEIWGEYPGAAVMLPVGRAFDVIEVSAEAGRRALVRMERMGLPLGPVTATPDGRAQFFVAPGAAAELPELLYRMGWDDADLDLRALGHGSFLTAPPSDRAGLGPAVWLRRPALDCAGGPPQARLLLGTLAYTCHRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX42</accession>
    <name>A0A0F4JX42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000054">
        <property type="protein sequence ID" value="KJY38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945785.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38715">
        <property type="protein sequence ID" value="KJY38715"/>
        <property type="gene ID" value="VR44_03050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7342"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27126" checksum="2B9A611A11CC29E5" modified="2015-06-24" version="1">MTHAMQKGSNIPVAATAVRAVLRWTPGPEVPDVDASALLVGADGRVRSDEDFVFYNQPRHPSGSVWRLGKKQVGDGVTDAVQADLRAVPPVVDRVLVVASAEDVPFQRVHDLRIQLYDASPGAAPEPLAHFDVRPETGAETALICGELYRRGEGWKFRALGEGYSDGLVGLATDHGISVDENAAEAGEGAAAAPAPGAGSADDRTAAMRPPAAAPVTQAPPPVQPAYGYPQQVSPVPVPAPGGDPSFRLPVQGPQFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXG0</accession>
    <name>A0A0F4JXG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945674.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39047">
        <property type="protein sequence ID" value="KJY39047"/>
        <property type="gene ID" value="VR44_02445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6779"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="151"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="30775" checksum="A62FFB10259B14F6" modified="2015-06-24" version="1">MTVGLDGTDAGSAAADWAAHEAELRNATLELVHAEDWAQYGPFAVPLPEPRRQWAEDLLSLTRDRLLRTHGTLDISTRGTRGIAAAKVLSSSAEDADLLVLGSRGLGAVAGFIVGSTGSATIRHTDTPVVLVRPFDSEHHPLRPADDAGPVVLGVDLHSNCDRLLAFACEEAARRSCPLAVLHCWSLPPALSYAPGLDPGVAQEMTDRLETTLRRLLSPWERKHPQLAVDTRILIGQPAIQLLDASSDAALLVVGRRIRRPALGARIGPITHAVMHHATSPVAVVAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXP3</accession>
    <name>A0A0F4JXP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945807.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38604">
        <property type="protein sequence ID" value="KJY38604"/>
        <property type="gene ID" value="VR44_03170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7849"/>
    <dbReference type="eggNOG" id="ENOG5033CIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040688">
        <property type="entry name" value="SLATT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18183">
        <property type="entry name" value="SLATT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLATT_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25819" checksum="9CD0046DC9882649" modified="2015-06-24" version="1">MQPEGPPRDPAEDGDLTGRPFPLGDWGEPAERLDELYRRVEADALRTAEWYLSDRAWKRRGARTLRAGAALGAVTGAAMPLLELTGSAPGVAPYGYLSLLLAAACLACDRFFGLTSGWMRDVATAQAVQRRLQTLQFDWASENVREVLGPTEGTASEAAERCLTVLRRFSEDVTELVRSETADWMVEFRAGPTPLAMQSLAVAPARPDPGVPPARFPLPPGTRPNMPRQRPPEQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXP5</accession>
    <name>A0A0F4JXP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000062">
        <property type="protein sequence ID" value="KJY38498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945864.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38498">
        <property type="protein sequence ID" value="KJY38498"/>
        <property type="gene ID" value="VR44_03490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7917"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16958" checksum="E7F1177A297671A5" modified="2015-06-24" version="1">MAEQGGVSVRVAGEADLDVAAELFRGYLEFYEVRVEDPARPREFLAERIAKDESLVLLGEVAGLGTVGFAQVYRTFSSLSLRPIWVLGDLYVAPSGRRTGAGRTLLREVLERAREAGVAGVQLETGFANEVAQGLYESEGFVREGYYIYFRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY09</accession>
    <name>A0A0F4JY09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945754.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38724">
        <property type="protein sequence ID" value="KJY38724"/>
        <property type="gene ID" value="VR44_02910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7314"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="41999" checksum="218E91A8DEB7CC36" modified="2015-06-24" version="1">MEPQAPAKAEEREPAGREEPEEREKKVTWSELFFDLVLVFAVTQVSALLHHDHGWAGTGRALIVFVPVYWVWVGNTVHANTHDADRPLNRLGLFAAGLCGLLMALALPDAFGDRGPLLAGAYFGARLVLAALAHGRSRRLRLTPVTLSVLISGPLLLAGAFLDGSARIWLWALAAAVDLAAPRLTRRNMVRLDFDSGHLAERFGLFVMIALGESIVAVGAPVASAPELDRGSLAAVAVAFALVCGLWWVYFHLAADAVRHGLETAAVRADVARQVLSYGHLSLIASIIAVAVGMAEAVAHPGARLPLGVAALLHGGCALFLATFGYTRWHLFRSWSVTRLTAAVVVLLLLPAAVLLPSLAALALLTAVVTGLNLVELALVRRRGELPGATSPSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY55</accession>
    <name>A0A0F4JY55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945547.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39317">
        <property type="protein sequence ID" value="KJY39317"/>
        <property type="gene ID" value="VR44_01810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5766"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29399" checksum="7A18405AB1DF4684" modified="2015-06-24" version="1">MTERKNARDQVALITGASRGIGRALALTLGRAGATVVVNYKKNADLAEKTVAELEEAGGRGLAVQADVETVEGVESLFATVREEFGRLDHFVSNAAAGAFKKILDFEPHHLDRTYAMNLRPFVLGAQQAVRLMDRGGRIVALSSYGSIRAYPTYAALGSMKAAIESWVRYMAVEFAPYGINVNAVNGGLIDSDSLEFFYGVPGMADMATVLERIPKGRPGSVQEVADTIAFLLSPGAEYITGQTLAVDGGLNVVAPPFFADTSAPLTLGERPTGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYC2</accession>
    <name>A0A0F4JYC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945768.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38738">
        <property type="protein sequence ID" value="KJY38738"/>
        <property type="gene ID" value="VR44_03000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7332"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471167" evidence="1">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13549" checksum="EBFEFFAF6DE4E20E" modified="2015-06-24" version="1">MRTWSTARVTTLAAALLAACALIPSTAGGAHAAGSPPCATGELCLWAKPDFKGTRAVYDLSTLDINSCTTLPAGPPGYQALVNRTGRPVTTYQSAECAETGEFQTYPGDGILLPQSPYQIRAFKVWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYN6</accession>
    <name>A0A0F4JYN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-butyrolactone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000020">
        <property type="protein sequence ID" value="KJY39477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39477">
        <property type="protein sequence ID" value="KJY39477"/>
        <property type="gene ID" value="VR44_01615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5681"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26181" checksum="2B8602C085237B2F" modified="2015-06-24" version="1">MRTERPQVKQDRAVRTRRAILQAAAVVFEERGYDAAKLSDIVNIAKVTKGALYFHFESKEGLAQAVIDAQNEDQPQALPQQYKAQEFIDIGMVFSHRMRHEVLIRASARLTLDQTGGELDRATPYETWIGVCADVLSEARRRGELLPGVDPVVPARLIVGAYAGLNTMSHTLGLDLDAQVAELYTHVMPNVVVPAVAIRLDTAPGRGARALYGPQGGHACRAGCANGVVPAGEFEETGVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ22</accession>
    <name>A0A0F4JZ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945421.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39642">
        <property type="protein sequence ID" value="KJY39642"/>
        <property type="gene ID" value="VR44_01055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2924"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020246">
        <property type="entry name" value="Uncharacterised_SCO3924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17260">
        <property type="entry name" value="DUF5326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7709" checksum="88F52BACFDD7B52A" modified="2015-06-24" version="1">MRAMFAGTPWWVKWVAVPLLALFVFGGIITTIIGTLIGFAFKVLLFAALVGGLIFVVKKFTGSGAKSSSSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K012</accession>
    <name>A0A0F4K012_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39745">
        <property type="protein sequence ID" value="KJY39745"/>
        <property type="gene ID" value="VR44_00630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2832"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25215" checksum="39FD9701D1A2AC34" modified="2015-06-24" version="1">MVGPGPQLGRDPVPLGAEGQQGVVGQDQAADVLALRVERVHGPGRELVQLQPVDGRGVVQPGPGTDHVGVPGVEVAAGHHTGGAEARREADDGSDVAEVARVVEQYDGRGAGRPREGGPPCVPVGPHGEGRDPGGVHPGQQPLELPPAHEPHDRFLHVGRELGGEGPHPLGLLGHDGHHLGPEPQGVLQRMEPVEHHNVVPPGILAPLPHHTHTPTLRPTRHYPASRGTIRPRRGLSSLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K049</accession>
    <name>A0A0F4K049_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945543.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39313">
        <property type="protein sequence ID" value="KJY39313"/>
        <property type="gene ID" value="VR44_01785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5761"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12695" checksum="B02E572F0EEFB522" modified="2015-06-24" version="1">MSKTDELLVDVARLVESGRSNQMSLTVVTGGAVITGRLAPEAVWRQRVSEVLADSDRLAEFSAVFAGAAAKDGPPTHLHFHLARILQGTVGIPETGGMYRVSIADISAWTMGDVSYSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0B9</accession>
    <name>A0A0F4K0B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_01305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945457.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4684"/>
    <dbReference type="EnsemblBacteria" id="KJY39549">
        <property type="protein sequence ID" value="KJY39549"/>
        <property type="gene ID" value="VR44_01305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2978"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="348" mass="35113" checksum="01652EA3733F60D9" modified="2015-06-24" version="1">MALLHRPQSEAAPVVSRETPTPWPGLGLAAGGALVAWCVHRLVPGIPMLTASVVLGIAVAHIPGVRTVVRGPARPGLSLAGRRLMRIGIVLLGLGLGLDQVLRLGWATVAMVSAVVAATFFGTVWLGRRLGLPGDQPLLIATGYSICGASAIGAVSEVSGSDEEDVAASVALVTLCGTLAIAVLPLLQGPLGLSDLSFGRWVGASVHDVGQVVATAQTAGPAALGEAVLVKLMRVALLAPLVAAVAFSMRARRRGVRTSSGKRPAPVPLFVAGFLAAAALRATGLLPHVALDWAHTAQEALLAAALFGLGSAVHLPTLARTGGRAALLGLGAWVVVAGVSYAGVLVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K198</accession>
    <name>A0A0F4K198_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="10" type="ORF">VR44_00175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945274.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1000"/>
    <dbReference type="EnsemblBacteria" id="KJY39914">
        <property type="protein sequence ID" value="KJY39914"/>
        <property type="gene ID" value="VR44_00175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.32"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32989" checksum="34C82AA0C91A8D49" modified="2015-06-24" version="1">MSDPNLNASHDSVESVEDQLDIVEAADAVDPDEVELADAEAGTAAEEAALHVEDDEDADAEAEEADEDSEDEGDVEDAAETADEDAEEAEEAAPAEPVDPIQALREELRLLPGEWYVIHTYAGYEKRVKANLEQRAVSLNVEEFIYQAEVPEEEIVQIKNGERKNVRQNKLPGYVLVRMDLTNESWGVVRNTPGVTGFVGNAYDPYPLTLDEIVKMLAPEAQEKAAKQAAEEAGLPAPAVKRTIEVLDFEVGDAVTVTDGPFATLQATINEINPDSKKVKGLVEIFGRETPVELSFDQIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1J5</accession>
    <name>A0A0F4K1J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_00525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000007">
        <property type="protein sequence ID" value="KJY39798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945316.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39798">
        <property type="protein sequence ID" value="KJY39798"/>
        <property type="gene ID" value="VR44_00525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.105"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9819" checksum="8B26223C7CDFF400" modified="2015-06-24" version="1">MWEARAVEGRGNELLEWARSQVLAREPLRREVLRAAQDRVLVITWWEVPQGGPAAELPELPEPAADLITRAVHRWRFESVEVTHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2N3</accession>
    <name>A0A0F4K2N3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">VR44_01700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6507"/>
    <dbReference type="EnsemblBacteria" id="KJY39421">
        <property type="protein sequence ID" value="KJY39421"/>
        <property type="gene ID" value="VR44_01700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5742"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="40493" checksum="5FE142FEAFA915C1" modified="2015-06-24" version="1">MSTKDFVEKDYYKVLGVPKDATEAEIKKAYRKLAREYHPDANKGDASAEERFKEISEANDILGDAKKRKEYDEARALFGNGGFRPGPGGGGSFNFDLGDLFGGAQGGGQGGFGGGLGDVFGGLFNRGAGAGAGTRTQPRRGQDIESEVTLSFTEAVDGATVPLRMSSQAPCKACSGTGDKNGTPRVCPTCVGTGQVSRGSGGGFSLTDPCADCKGRGLIAENPCEVCKGSGRAKSSRTMQVRIPAGVSDGQRIRLRGKGAPGERGGPAGDLYVVVHVGTHPVFGRKGDNLTVTVPVTIAEAALGADIKVPTLGGPAVTLKLPPGTPTGRTMRARGKGAVRKDGTRGDLLVTVEVAVPAELSDKAREALEMYRDATESDDPRALLFESAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K392</accession>
    <name>A0A0F4K392_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VR44_01025</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4739"/>
    <dbReference type="EnsemblBacteria" id="KJY39641">
        <property type="protein sequence ID" value="KJY39641"/>
        <property type="gene ID" value="VR44_01025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2918"/>
    <dbReference type="eggNOG" id="COG1017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="18">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="149"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJY39641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="41269" checksum="23DDC34CC61640DC" modified="2015-06-24" version="1">MPSGGGATEPSPDAVLIRRTLAEVAPVADKVTSYFYALVFTGHPQLREMFPVAMDVQRDRLLKALLTAAEHIDDPAVLTPYLRRLGTGHRKYGTMAAHYPAVGEALIGALARYAEFTWGPEAEAAWVRAYTAISQIMIDAAAEDEVRAPAWWHAEVVSHDLRTSDIAVLTVRPDQPYPFLAGQYTSLETPWWPRVWRHYSFASAPRADGLLSFHVKAVPAGWVSNALVRRARPGDVLRLGPPAGSMVVDHSTDNGMLCLGGGTGIAPIKALIEDVAEHGERRPVEVFFGARSDDDLYDKDTLLGLQRSHPWLSVRPVIGEGMAGQLPHAVGENGPWSSYDAFISGPPAMIRSGVDALKRIGIPGERIRYDALEELAGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3J3</accession>
    <name>A0A0F4I3J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001739">
        <property type="protein sequence ID" value="KJY16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16555">
        <property type="protein sequence ID" value="KJY16555"/>
        <property type="gene ID" value="VR44_40395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6734"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="20667" checksum="7E610A64D7EC9BBE" modified="2015-06-24" version="1" fragment="single">MQVLESYLSLLATVAIAGGEPGMIASGVLGGISAGLKLLFPPRATDFGTELTKQLNALDKLLVEQMAEQSVRDDMAKFLGDVTTLLQVIKTSDHLFQRFAKDPDPDAFAASSDTQDLRDKVNAACEGLDQFRPTLNELPLSKHTTPDSKFLTLGLYATGAALHMQLELMRAMWQGTTSESPWAHNLVSCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I624</accession>
    <name>A0A0F4I624_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001669">
        <property type="protein sequence ID" value="KJY17425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952604.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001669.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17425">
        <property type="protein sequence ID" value="KJY17425"/>
        <property type="gene ID" value="VR44_39970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6330"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8167" checksum="C2CEEB2FF948473A" modified="2015-06-24" version="1" fragment="single">DPDDPDLGPVPGGVYVELVGGPLDGQLLDAIGWSPLELADGALLMSERGAFGPGGRSAYEPAEVDGVYPSRFGWRGDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7R9</accession>
    <name>A0A0F4I7R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001626">
        <property type="protein sequence ID" value="KJY18085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18085">
        <property type="protein sequence ID" value="KJY18085"/>
        <property type="gene ID" value="VR44_39715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6124"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="29079" checksum="17FA49794FD6A1ED" modified="2015-06-24" version="1">MPLSIEHRPDEGRAVATVHAALDAGVTLIDTADSYHWHAGETGHNERLIARALARYGGDTSGVLIATKGGRGRPGDGTWTVTGTPGHLKRAAEASAVRLGVDAIGLYQLHKPDPAVPWAESVGALRELLDAGTIRSAGISNVTTAQIREAYGILGDGLVSVQNQYSPAVRDSEPQLRLSTELGLAFLPWSPLGGISRSSLDGPSGPTSADTAFHRVAARHGVSPQRVALAWLLSRSPSVIPLPGASRPASITDSAAAARLELTATELAELEEPLTPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAN1</accession>
    <name>A0A0F4IAN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001650">
        <property type="protein sequence ID" value="KJY17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952587.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001650.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17726">
        <property type="protein sequence ID" value="KJY17726"/>
        <property type="gene ID" value="VR44_39855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6272"/>
    <dbReference type="eggNOG" id="ENOG502ZVND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="17443" checksum="E02EBD2CCB406785" modified="2015-06-24" version="1">MAWLYAEYIADELLRTGRLIPVSTLEFRAGRDTLALTIYLSDAAGELSGIRVVSQLDEWLSLTAYGHPWRDWVQTRFLTLGEEARERGRGEDPDLELARAAWRWLDHTELFATNLDPDHPAQAGPPPGLDENARVWTPAWQLGLPLGHLAMHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE23</accession>
    <name>A0A0F4IE23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001542">
        <property type="protein sequence ID" value="KJY19718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19718">
        <property type="protein sequence ID" value="KJY19718"/>
        <property type="gene ID" value="VR44_39020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469833" evidence="2">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY19718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="26230" checksum="A73F494CAC067363" modified="2015-06-24" version="1" fragment="single">MEALAASRAPFLLGVRHHSPALAAVVPALLDAADPEVVCVELPADFQPWLPHLADPETVAPVALAGLGREGRLAFYPFADFSPELAAVRWARERGVRVLCCDLPLGDRGWSSPSPAEPAPTGTDGPPAAGAAGRGADGPATASAGYASDDAEAAPAPAGPAGADADGSVPAPARPGTHGGSGSRAADCDSESAAPAPAVAEADRLAGPGSGAAVHGGAARRSYADALAASVPGARATTCGTARSRSSPRAAPRRPCAAPPSVSAGPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEP5</accession>
    <name>A0A0F4IEP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_38925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001531">
        <property type="protein sequence ID" value="KJY19928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19928">
        <property type="protein sequence ID" value="KJY19928"/>
        <property type="gene ID" value="VR44_38925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY19928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16282" checksum="28790901DDF4BAD2" modified="2015-06-24" version="1" fragment="single">LDAEALRAQARAGTLPPLLRKLVRTSVRRSLDSAPRTTAGHTPLGDRLAALPADERHAFLLDLVRTQVAAVLGHASTRSVAVDRQFRDLGFDSLTAVELRNLLGSATGLRLPATLVFDHPTPEALARLLLAELLGTDADPAEPAGSVEAVAVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH36</accession>
    <name>A0A0F4IH36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001474">
        <property type="protein sequence ID" value="KJY20969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952323.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001474.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20969">
        <property type="protein sequence ID" value="KJY20969"/>
        <property type="gene ID" value="VR44_38445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469792" evidence="3">
        <location>
            <begin position="38"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY20969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="549" mass="58891" checksum="7A0454A9C7F4C986" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIV0</accession>
    <name>A0A0F4IIV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001438">
        <property type="protein sequence ID" value="KJY21940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952264.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21940">
        <property type="protein sequence ID" value="KJY21940"/>
        <property type="gene ID" value="VR44_38120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5228"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="34717" checksum="0B187045B1922FF4" modified="2015-06-24" version="1">MRMLINSADTVVADALHGMAAAHPELDVDVERRVVLRRDAKTGGRVGLVSGGGSGHEPLHGGFVGYGMLSAACPGEVFTSPVPNQMLHAAAGVDSGQGVLFIVKNYTGDVLNFQMAAELAEEDGLSVERVLVNDDVAVTDSLYTAGRRGTGATLFVEKIAGAAAEEGAPLDRVAALARQVNESSRSFGVALSACTTPAKGSPTFQLPEGELELGIGIHGEPGRERRAMMTAREIADVAVGAVLDGLAETGGPADGPVLALVNGMGATPLLELYGFHAEVARILAARGVPVARALVGNYVTSLDMAGCSVTLCRADEELLRLWDAPVQTPALRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIX1</accession>
    <name>A0A0F4IIX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001447">
        <property type="protein sequence ID" value="KJY21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952277.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21649">
        <property type="protein sequence ID" value="KJY21649"/>
        <property type="gene ID" value="VR44_38195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5246"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8511" checksum="FF62BBD0AE0E64E8" modified="2015-06-24" version="1">MSLTLVMEHVEAPSTSTSLAPREQEALRHIAAGCTYLQAARNMGLSKHTVDAYLRRIRAKFGVNTTAELTRLAISLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKP3</accession>
    <name>A0A0F4IKP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001413">
        <property type="protein sequence ID" value="KJY22610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22610">
        <property type="protein sequence ID" value="KJY22610"/>
        <property type="gene ID" value="VR44_37820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5123"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046129">
        <property type="entry name" value="DUF6126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19621">
        <property type="entry name" value="DUF6126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6546" checksum="1597E2FA42299EAA" modified="2015-06-24" version="1">MVMTDDGQERGGPGKRAAAEQEKWKAKGVALRAFFYIAGTHVFAAFVMLLFYLGQHAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQU9</accession>
    <name>A0A0F4IQU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001232">
        <property type="protein sequence ID" value="KJY24405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951764.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24405">
        <property type="protein sequence ID" value="KJY24405"/>
        <property type="gene ID" value="VR44_35460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4206"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="33102" checksum="A65CAF92534B795D" modified="2015-06-24" version="1">MNEYGRYAPQQEPTTFWQEPDQEHHTAYGRPFFGLGEMTASWDPSEELAHLCREAMAPGRAEPLDQVVYGETGETVSGAGLASGLTSGPGPGLTPGPAGGGFSPGTGRPPRASAPGGHRRGSRAKTPGVALLWTGSLCTAVLVAVIAAVVSIFSGLAICEALRHSAGPRTAHDVASWWPLLIYGPWMVASLSILRAALHQRRAVHSWSIVLLFSTLATLLCVAQAPRTLAAEAAATLPPIAALACFQQLVRQITLTRPPRQTAARHRTGRSPQLRPPTTASSPGTPLPDYSVRDRRESLRASTGYRFRYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR37</accession>
    <name>A0A0F4IR37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001284">
        <property type="protein sequence ID" value="KJY24139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24139">
        <property type="protein sequence ID" value="KJY24139"/>
        <property type="gene ID" value="VR44_36235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16971" checksum="DE3D7ED4A419FBC7" modified="2015-06-24" version="1" fragment="single">MWHEDMLWGQTLRSTVAHAEIVSIDISEALAMPGVYSVLTYDDLPAEMKNYGLEIQDTPVLANGRVRHHGEPVALVAADHPETARRAAAKIKIDYKELPLVTDEASALAADAPLIHPGRDDHHAGHVPHPNIVHRQPIIRGNVEEARKRADVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRE3</accession>
    <name>A0A0F4IRE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001198">
        <property type="protein sequence ID" value="KJY24590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24590">
        <property type="protein sequence ID" value="KJY24590"/>
        <property type="gene ID" value="VR44_34925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="25505" checksum="90DE3082AD43D076" modified="2015-06-24" version="1" fragment="single">MPRPENDAPVPSHGTTPDPGGGFTDPAPGREGIIVQGGRTPSGSNDPRAIGPKQDDPRAIGPKQDDPRAIGPKQDDPRAIGPKQDDPRAIGPKQDDPRAIGPKQDDPRAIGPKQDDPRAIGPKHDDPHAVRDGIIVQGGRTGHPGGNARQKRARKTKTMALVIGGVMVLAVGGFLVGRQLGHDPATLQPQAVATPTAAVSGGAPAPSASSDGGSPAPPATPGAPATEVASSPTPAASEPPARNGSGPTPARSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS00</accession>
    <name>A0A0F4IS00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001259">
        <property type="protein sequence ID" value="KJY24263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24263">
        <property type="protein sequence ID" value="KJY24263"/>
        <property type="gene ID" value="VR44_35875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8063" checksum="7A47F41C83E381C5" modified="2015-06-24" version="1" fragment="single">MPQPPLIGITTYLAHAQWGEWDLPAAVLPAAYADCVRASGGRAVLLPPDAPEAAADVVGRLDAIVLAGGEDLDPALYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS31</accession>
    <name>A0A0F4IS31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001166">
        <property type="protein sequence ID" value="KJY24812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24812">
        <property type="protein sequence ID" value="KJY24812"/>
        <property type="gene ID" value="VR44_34255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8775" checksum="FA3547C852529625" modified="2015-06-24" version="1">MLDDLVAEGVHAAGAQGGEEVVLQERVDVEEGGGARWRWPCFHSQVYSRKVTGPYFAMRSVRVWLAGADFVRCRQPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS39</accession>
    <name>A0A0F4IS39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001161">
        <property type="protein sequence ID" value="KJY24840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24840">
        <property type="protein sequence ID" value="KJY24840"/>
        <property type="gene ID" value="VR44_34185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="11252" checksum="5C6ED52810D0F78A" modified="2015-06-24" version="1" fragment="single">TPDPYGAPGARMYRTGDLARRRPDGTVDYLGRSDQQVKIRGHRIEPGEIEAELVRGPQVGHAAVVVREDTPGEQRLVAYVVPSEGQVADPAELRRALAERLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISC5</accession>
    <name>A0A0F4ISC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_35525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="JZWV01001235">
        <property type="protein sequence ID" value="KJY24388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951775.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001235.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24388">
        <property type="protein sequence ID" value="KJY24388"/>
        <property type="gene ID" value="VR44_35525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4218"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="101"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="381"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY24388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="583" mass="63712" checksum="ECD39E408F838F9E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISQ6</accession>
    <name>A0A0F4ISQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001218">
        <property type="protein sequence ID" value="KJY24493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951714.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24493">
        <property type="protein sequence ID" value="KJY24493"/>
        <property type="gene ID" value="VR44_35180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4115"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="349" mass="36905" checksum="BB2F2FB289AD856C" modified="2015-06-24" version="1" fragment="single">AGHFRRLLAEAERLGLADERAEALLGLGDCALEAGELTEAAGHFEAAELLLADEPLPRRARPIRGRAVAHLLAGELRYACYLLESAIDGLNAGGLADPEALVLLYSAVIGPYIDMGAHARAAHAAELALALAPQVADPALVAGMHRQVARTFLAEGRVADADASLAKAQAVYRQLRLRTDLAHCHWMRGYVQAQHGELAAAERELRIAREMLTARRAALYTAQVEVELADVLRRLGRHEEAAELVSGLLAEGSDPGAVHAGGAHRLLGLIAEERGDAEAAEEHYVRALALLERSGAGGDLADLCRLLGDLLRRAGRTEAALDAYRTGLGHRAAPGTTTLGPAPAAPAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISS9</accession>
    <name>A0A0F4ISS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001368">
        <property type="protein sequence ID" value="KJY23766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952115.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001368.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23766">
        <property type="protein sequence ID" value="KJY23766"/>
        <property type="gene ID" value="VR44_37350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4888"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046030">
        <property type="entry name" value="DUF5988"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19450">
        <property type="entry name" value="DUF5988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7891" checksum="F8961A47FD812FCB" modified="2015-06-24" version="1">MNDSDTAKAVLEGGPADLTERVVAQPEAGADVKLLFRGGYEHFRRTERTQDTAEGRLPVYEWWERTELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX0</accession>
    <name>A0A0F4ISX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001122">
        <property type="protein sequence ID" value="KJY25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25092">
        <property type="protein sequence ID" value="KJY25092"/>
        <property type="gene ID" value="VR44_33455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6582" checksum="1ACCAE122768100A" modified="2015-06-24" version="1">MVRTQEPQSVPALVTEAIWRGVQAPAAACSLTCLSVTPKQEQTYTRFTSLSGMVLAATPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT29</accession>
    <name>A0A0F4IT29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">VR44_34795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001193">
        <property type="protein sequence ID" value="KJY24618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951639.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001193.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2565"/>
    <dbReference type="EnsemblBacteria" id="KJY24618">
        <property type="protein sequence ID" value="KJY24618"/>
        <property type="gene ID" value="VR44_34795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4030"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="22295" checksum="305EC5994209C427" modified="2015-06-24" version="1">MGEQEVPTGPVKRRLGVMGGTFDPIHHGHLVAASEVAALFHLDEVVFVPTGEPWQKSQRAVSPAEDRYLMTVIATASNPQFSVSRIDIDRGGPTYTIDTLRDLSALNQDADLFFITGADALAQILTWRNADELFSLAHFIGVTRPGHVLTDDGLPEGGVSLVEVPALAISSTDCRARVAEGDPVWYLVPDGVVRYIDKRELYRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITE4</accession>
    <name>A0A0F4ITE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001173">
        <property type="protein sequence ID" value="KJY24748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951568.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene47"/>
    <dbReference type="EnsemblBacteria" id="KJY24748">
        <property type="protein sequence ID" value="KJY24748"/>
        <property type="gene ID" value="VR44_34385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3855"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27710" checksum="BB065FC72D03FBC2" modified="2015-06-24" version="1">MALLDKDGVRLTIDDTVATVTLTNPAKRNAQSPALWRALAEAGRSLPGSVRVVVLRGEGKSFSAGLDRQAFTPEGFEGEPSFLDLARGSDELLDSTIAEYQEAFTWWRRNDIVSIAAVQGHAIGAGFQLALACDLRVVADDVQFAMRETSLGLVPDLAGTQPLTALVGYARALEICATGRFVHAEEAERVGLANLVVPADELDAAVQDLTTALLAPPRDAVIETKALLREAGSRTYDDQRGAERAAQARRLRDLAGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITM4</accession>
    <name>A0A0F4ITM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951251.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25375">
        <property type="protein sequence ID" value="KJY25375"/>
        <property type="gene ID" value="VR44_32670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3345"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17816" checksum="0BD16D0F9B81ED83" modified="2015-06-24" version="1" fragment="single">FKHWNAGANTSDGCNTRAEVILEEAVEQPEISAGCKLSGGRWFSLYDDTWVTSASSLDVDHLVPLAEAWDSNASTWTAARREAYANDLATPTSLIAVTARSNRAKADKDPADWLPPAAGYHCAYATGWVETKLRWGLAADDRERAALLGVAEECPGATLSYETVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU35</accession>
    <name>A0A0F4IU35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001270">
        <property type="protein sequence ID" value="KJY24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951873.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001270.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24201">
        <property type="protein sequence ID" value="KJY24201"/>
        <property type="gene ID" value="VR44_36045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4367"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="25690" checksum="DBA996A424406E99" modified="2015-06-24" version="1">MSRGVLVTGASRGIGRAVAAAFARQGDRVAVHASAPHADARETLAALDGEGHVLVTGDLGDPARVEDLVAEAADALGGVDVLVNNAAAMVAHPLPTTSYADWQAAWRRTAAVNLFGAADVSYCVARRMIDGGRPGHIVNVGSRGAFRGEPDHPAYGATKAALHAFGQSLAVSLAPHGITVASVAPGFVATERVSGRLQGEEGERIRAQSPFGRVAEPEEIAAAVLYLASPEARWSSGAVLDVNGASYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUH0</accession>
    <name>A0A0F4IUH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001039">
        <property type="protein sequence ID" value="KJY25660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25660">
        <property type="protein sequence ID" value="KJY25660"/>
        <property type="gene ID" value="VR44_31895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11890" checksum="CED41805150255CA" modified="2015-06-24" version="1" fragment="single">RAARAAAAVLRGGLEPPAEVAYRDGEVYLPTLGLLRLGEPGTEGRAALHATGEGYAVVRAGRTEHRFGPAAGDARWLPVRTWQPGPQQPPVALEDLDPYRNCFARPPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV42</accession>
    <name>A0A0F4IV42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001013">
        <property type="protein sequence ID" value="KJY25900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950997.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25900">
        <property type="protein sequence ID" value="KJY25900"/>
        <property type="gene ID" value="VR44_31315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2751"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="33035" checksum="8E6137F20FC557F3" modified="2015-06-24" version="1">MPGTERTLEGRVALVAGATRGAGRGIAVQLGASGATVYVSGRSTAGRPSEYGRPETIEETAALVTAAGGRGVPVVADHLVPEQVEALVARIEAEQGRLDLLVNDVWGGEQLFEWESPVWEHDLDRGLRLLRLAIDTHAVTSHFALPLLLREPGGLVVEMTDGTAEYNATRYRNSFFYDIAKSAVLRMAFALGHELGPRGATAVALTPGWMRSEMMLDAFGVTEANWRDALKEVPHFAISETPSYVGRAVAALAADPEVSRWNGQSLSSGQLAGVYGFTDLDGSRPDAWRYMVEVQDPGRPADTTGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVQ8</accession>
    <name>A0A0F4IVQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000984">
        <property type="protein sequence ID" value="KJY26092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26092">
        <property type="protein sequence ID" value="KJY26092"/>
        <property type="gene ID" value="VR44_30870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2676"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14926" checksum="8EEEA9E8675F8085" modified="2015-06-24" version="1" fragment="single">TKAAALFREIRERGYRGSRVVVTKYIATLRAGTAAPEPRQPIPSPRRITTWILRRLDTLTESHREQLDRILDACPDLATARDLAREFSAIARERRGHDLRHWVARALATRGRNRSRASRPSSRTTGTPSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWV7</accession>
    <name>A0A0F4IWV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000929">
        <property type="protein sequence ID" value="KJY26530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950736.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000929.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2664"/>
    <dbReference type="EnsemblBacteria" id="KJY26530">
        <property type="protein sequence ID" value="KJY26530"/>
        <property type="gene ID" value="VR44_29860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2352"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="1">
        <location>
            <begin position="65"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="539" mass="58123" checksum="77E2F9C59AE51567" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXT9</accession>
    <name>A0A0F4IXT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000938">
        <property type="protein sequence ID" value="KJY26454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950768.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000938.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26454">
        <property type="protein sequence ID" value="KJY26454"/>
        <property type="gene ID" value="VR44_30030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2389"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470234" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23288" checksum="3ABEBDEC3E7C31DD" modified="2015-06-24" version="1">MPLRRIALGAAVAALTALATPAQAQASAAAPSLPPPGRVTVDVAGVNGSGCPQGTAEVAAASDNTAFTVTYSNYLAQTGAGSGGTDFRKNCQLALRIRVPQGFTYAIARADYRGFAHLQRGAYGQQRANYYFQGNAQTTRSTHQFNGPLTDNWQASDQTDYADLVWAPCGEERNLNVNTELRVYAGTSGSQNLSFMSMDSTDGSVSTVYHFEWRECPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXU2</accession>
    <name>A0A0F4IXU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000959">
        <property type="protein sequence ID" value="KJY26283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26283">
        <property type="protein sequence ID" value="KJY26283"/>
        <property type="gene ID" value="VR44_30440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2502"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470386" evidence="2">
        <location>
            <begin position="32"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="640" mass="69297" checksum="E2992A1BF1F12BED" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYD1</accession>
    <name>A0A0F4IYD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001035">
        <property type="protein sequence ID" value="KJY25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25686">
        <property type="protein sequence ID" value="KJY25686"/>
        <property type="gene ID" value="VR44_31845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="36291" checksum="931F6BE54C202E8F" modified="2015-06-24" version="1" fragment="single">ELFRTAGAEPAIRKEASALEANQGILQTQALIGGEHKWLIKAVDPSGALARFSPTGWCLCSQNNIEPVLAAQSRAQGADVRFSTELMTFDQDAEGVTCLVKDRGTGEHLTVRADYLIAADGPRSPVREALGIRQAGSGELFHNVSIVFRSERLAGLLGDLRFIVCYLMRPGADGALLPVDNETQWVFHAPWHPETGETLEDFTEERCIAQIRNAIGVPDLDVEIGGKAPWHAAERVAQQYSVGRVFVVGDAAHEMSPTGAFGSNTGIQDAHNLAWKIAAVLNGSAGPDLLHTYEDERLPVARATSERASARSAEHSHPGYVPPPTMGGGPGSGVLTTAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYF2</accession>
    <name>A0A0F4IYF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000935">
        <property type="protein sequence ID" value="KJY26483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26483">
        <property type="protein sequence ID" value="KJY26483"/>
        <property type="gene ID" value="VR44_29965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2375"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470248" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="25146" checksum="042BD3FF8D3995B4" modified="2015-06-24" version="1">MIKHLTARGLTALALTALPLLATTPANGAALGQAPATAPALHRRVFPEPPPADVVRAELDRLTVEPPHSMAGYSRAMFPHWAKQYGECDTREVVLSRDGHEVTQDSACRAITGTWYSEYDDKTFDSASKIDIDHMVPLANGWRSGADTWDTAKRKRFANDLDNSQLIAVSAASNRSKGDQAPDQWAPPNTFYWCTYSRAWTHIKSLYELSITPTERTKLIEMLSTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYJ5</accession>
    <name>A0A0F4IYJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000929">
        <property type="protein sequence ID" value="KJY26528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950734.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000929.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26528">
        <property type="protein sequence ID" value="KJY26528"/>
        <property type="gene ID" value="VR44_29845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2350"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470408" evidence="2">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19437" checksum="A07ADAE35609000F" modified="2015-06-24" version="1">MNRRPLVIAAAIVGALATAAFALPNLPPNPLTNALNDRFFKEKGRHFATAGAAQAHARGDRALALPSWVPGDATDIRIQARADGKARLIRFTLGKTPLDGPQCAAEHPKKAGGPRLGARWWPRDIRAEERPECRDRYQYQVSVRGKKVYAWTDGTPSPGTRIPEGTPAVPAPGAVPAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYT4</accession>
    <name>A0A0F4IYT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000861">
        <property type="protein sequence ID" value="KJY27185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000861.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1425"/>
    <dbReference type="EnsemblBacteria" id="KJY27185">
        <property type="protein sequence ID" value="KJY27185"/>
        <property type="gene ID" value="VR44_28245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1892"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="20924" checksum="0901B3D2479B6A58" modified="2015-06-24" version="1">MIRLLLAEDQGMMRGALALLLGLEEDIEVVAQVAAGDEIVPAALEARPDVALLDIELPGRSGLDAAADLRTACPGTRVLILTTFGRPGYLRRAMEAGAAGFLVKDGPVEELAAAVRRVLAGETVIDPSLAAAALSAGPNPLTPREADVLNAAVDGATVADIAARVHLSESTVRNYLSAAIGKTGTRNRMEAVRAARRQGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYW2</accession>
    <name>A0A0F4IYW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000897">
        <property type="protein sequence ID" value="KJY26844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26844">
        <property type="protein sequence ID" value="KJY26844"/>
        <property type="gene ID" value="VR44_29085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="540" mass="55988" checksum="AAF7B93AED58635C" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ56</accession>
    <name>A0A0F4IZ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000905">
        <property type="protein sequence ID" value="KJY26768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950628.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000905.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26768">
        <property type="protein sequence ID" value="KJY26768"/>
        <property type="gene ID" value="VR44_29265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2201"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19875" checksum="7A802C235CE92669" modified="2015-06-24" version="1">MSVGAARVCFVDELVERVDCQDRVLGVVTRAQAVREGWLHRIASTVCRDERGRILVHRRSEQLSRFPGLYEVMVGGAVGVGESYEQAAGRELAEELGIRDLPRLLFTFINRSGLSPHWLGVHEAVVPDAVTRDPQEVAWCGWLTESELHSALLEWRFTPDSHEAFSRYLVFRASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZB6</accession>
    <name>A0A0F4IZB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_27745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000843">
        <property type="protein sequence ID" value="KJY27370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M04.017"/>
    <dbReference type="EnsemblBacteria" id="KJY27370">
        <property type="protein sequence ID" value="KJY27370"/>
        <property type="gene ID" value="VR44_27745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1787"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P/Homo B" evidence="4">
        <location>
            <begin position="89"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="21507" checksum="8DCB78CB85BA88AB" modified="2015-06-24" version="1" fragment="single">ASEGSGAKTINGVNYDSPTSDGLPVTGIGRDKAQLIWYKALTTKFNSTTDYAGAREGTIAAATDLYGAGSAEVNAVTDAWAAVNVGARSGGGTPTPGNVFESTTRVAIPDSPGPAVTSSVNVTGITGNAPSTLKVGVKITHTYIGDLQIDLVAPNGTSFRLQNSSSDSTANLDKTYTVNASAVPANGTWKLKVQDKAAADTGTITDFKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZF2</accession>
    <name>A0A0F4IZF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">VR44_29035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000895.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene541"/>
    <dbReference type="EnsemblBacteria" id="KJY26863">
        <property type="protein sequence ID" value="KJY26863"/>
        <property type="gene ID" value="VR44_29035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2139"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21441" checksum="39D5A64D4660E9F1" modified="2015-06-24" version="1">MSDDTAPWLIVGLGNPGAEYAGNRHNIGFMVADLLAERIGGKFKAHKARAQVVEGRMGPPGPLNRRVVIAKPMSFMNLSGGPVTALRDFYKVPVERIVAVHDELDIDYATLRLKLGGGDNGHNGLKSMTKAMGADYHRVRCGIGRPPGRMQVADFVLKDFSSTERKELDWFVDRSADAVECLVQEGLERAQSAYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0G0</accession>
    <name>A0A0F4J0G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007264019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000858.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27213">
        <property type="protein sequence ID" value="KJY27213"/>
        <property type="gene ID" value="VR44_28175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1878"/>
    <dbReference type="eggNOG" id="ENOG503475H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="9181" checksum="E70483190DF1F90D" modified="2015-06-24" version="1">MGAHRRRCDWCNNGTPIVRDMEPVNPDYQYWCEECARALIIKGDPIETYRELEGEPIYGRLLDEHCTLKRFYQFARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1B2</accession>
    <name>A0A0F4J1B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tripeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000809">
        <property type="protein sequence ID" value="KJY27659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27659">
        <property type="protein sequence ID" value="KJY27659"/>
        <property type="gene ID" value="VR44_27095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1604"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22303" checksum="57D7D534A820482B" modified="2015-06-24" version="1" fragment="single">WVPVAQAFSAWAAGDEKPLIEANAPDMSDLKGNAASENSNAVYTAVECADAKWPTSWAKWDRDNTELNKKYPFLTWSNAWMNLPCATWKSKQSTPIEVGAKSIAPVLIVQSERDAATPYQGGVELHRRLAGSRLITEQNAGSHGVTSLVNPCINTRVESYLLTGKVDAADVKCGPHATPVPPAPAAAKSLAQAPASELAKREELPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1R7</accession>
    <name>A0A0F4J1R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_25860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000751">
        <property type="protein sequence ID" value="KJY28232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28232">
        <property type="protein sequence ID" value="KJY28232"/>
        <property type="gene ID" value="VR44_25860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1277"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="133"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="598" mass="60689" checksum="06972A574E649923" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J230</accession>
    <name>A0A0F4J230_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000882">
        <property type="protein sequence ID" value="KJY26956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950536.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000882.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26956">
        <property type="protein sequence ID" value="KJY26956"/>
        <property type="gene ID" value="VR44_28755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2083"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="38032" checksum="0C2E11B4E4ED8839" modified="2015-06-24" version="1">MSPTPPAPPAAPASPSTARAMNDRLALELLQAEGALTATQLKQLTGLSRPSVADLLERLCAAGLVEVVGESGEQRRGPNARLYGIVARRAHLAALDVRTDSATAVVTDLLGRQLASAELPVDAVDEAVDRLEALARRARAEALHTVVVGAPGLVAPASGELRDTSGLPAWHRDLVAALQRRLTAAVGVENETNLAALAEQRVGAARDLDSFVLLWLGAGVGAAVVLDGRLRRGASGGAGEIGFLPVPGTAALPSATDCGGGFHALAGAAAVAALAAEHGFGGPVEEAVAGAAGEAFLDALAERLALGAAAVAAVLDPGCVVLGGGLGRAGGDPLAARVARRLAALSPVPTEVRATALGDPAVLEGARLAAREAAQSQLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J390</accession>
    <name>A0A0F4J390_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949947.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28334">
        <property type="protein sequence ID" value="KJY28334"/>
        <property type="gene ID" value="VR44_25590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1217"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="662" mass="72055" checksum="2F92988D6DA182AB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3A7</accession>
    <name>A0A0F4J3A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_25910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000754">
        <property type="protein sequence ID" value="KJY28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950014.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000754.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28188">
        <property type="protein sequence ID" value="KJY28188"/>
        <property type="gene ID" value="VR44_25910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1246"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="543" mass="55600" checksum="D12962869A473E88" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3K0</accession>
    <name>A0A0F4J3K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000745">
        <property type="protein sequence ID" value="KJY28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28283">
        <property type="protein sequence ID" value="KJY28283"/>
        <property type="gene ID" value="VR44_25730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27312" checksum="F454F6AEC693B995" modified="2015-06-24" version="1" fragment="single">VLPLPPLPGGRASLDDLDPYRAPAAGHPAPVRPARRLTPKGHKRWDTQWTGALTLLERYDSARADEAARLLRSVVPLGGGARSSGATLPAAAGSVLARGQSPPALAATLVHEVQHGKLAALTDVLTLHTADRTPRHWAPWRTDPRPLEGLLHGTYAHLALAGYWQRAALYGARGAWAQHARIRAQVAAVLPVLRDHPRLTLAGREFVDGMTDAERAMDELPPPGDRYATARRALERERLAWCAAHPELAASTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3T0</accession>
    <name>A0A0F4J3T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000737">
        <property type="protein sequence ID" value="KJY28373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28373">
        <property type="protein sequence ID" value="KJY28373"/>
        <property type="gene ID" value="VR44_25525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9598" checksum="5D7D2DA6B9E7B5C5" modified="2015-06-24" version="1" fragment="single">DEVVAHCLSVELESSDGHNDTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPDHLSWEEAASPGLVNSTAYRQLVSRNGAGMKQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J442</accession>
    <name>A0A0F4J442_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000682">
        <property type="protein sequence ID" value="KJY29040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949642.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000682.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1371"/>
    <dbReference type="EnsemblBacteria" id="KJY29040">
        <property type="protein sequence ID" value="KJY29040"/>
        <property type="gene ID" value="VR44_23925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="31100" checksum="B4C3FDEC428DEF59" modified="2015-06-24" version="1" fragment="single">MERRTIKIAMNGVTGRMGYRQHLVRSLLALREQGGLDLGDGTLLWPEPVLVGRREDALRAVAERHSLEHVTTDLGAVLADPEVEVYFDAQVTGAREAALRRAVAAGKHVYCEKPTALDFPAALELARLAAAAGVKHGVVQDKLFLPGLLKLRRLIEGGFFGQVLSVRGEFGYWVFEGDGQPAQRPSWNYRAQDGGGIVTDMFPHWEYLLHELFGRVRTVQALTRTHIGRRWDEEGKPYEATADDAAYGIFELEGGAVAQINSSWTVRVHRDELVEFQVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4G2</accession>
    <name>A0A0F4J4G2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949543.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5181"/>
    <dbReference type="EnsemblBacteria" id="KJY29242">
        <property type="protein sequence ID" value="KJY29242"/>
        <property type="gene ID" value="VR44_23390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.620"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="3">
        <location>
            <begin position="55"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="2">
        <location>
            <begin position="268"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="43329" checksum="CA8458BDF66218C6" modified="2015-06-24" version="1" fragment="single">GHEYAERAVAAGAAAVLAARPVGVPAIVVDDVEKALGALARAVVGRLGTDVVALTGSAGKTSTKDLIAQVLQHHAPTVWTPGSLNNEIGLPLTALKATAETRHLVLEMGARGIGHIAYLTGLTPPRIGLVLNVGTAHIGEFGGREAIAQAKGELVEALPSEAEGGVAVLNADDLLVRAMSARTKARTVLFGEAEDADVRATEVRMTPSGQPSFTLHTPTGCSDVTLRLYGEHHVSNALAAAAVAHVLGMSVEEIATALSGAGTLSRWRMEVTERADGVTIVNDAYNANPESMRAALRALAAMGGAGKEGGGRTWAVLGPMAELGDASLAEHDAVGRLAVRLNVSRLVAVGGREASWLQLGAYNEGSWGEESVLVSDAQAAIDLLRSELRPGDVVLVKASRSVGLERVALALLQGEGEVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Q9</accession>
    <name>A0A0F4J4Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000707">
        <property type="protein sequence ID" value="KJY28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949796.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000707.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28718">
        <property type="protein sequence ID" value="KJY28718"/>
        <property type="gene ID" value="VR44_24760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.953"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="37777" checksum="B82D49F66038D67D" modified="2015-06-24" version="1" fragment="single">SPSGGAPSGAGGSPPGSPAAASAGAAPGAGASAPPAKGSVTVTGEVAKGLDSPWGVAPLPGGDLLVASRDKGTISRVRTDTGEVTQIGRVPGVAPGGEGGLLGLALSPHFASDRLVYAYFTTESDNRIARMRYDEQRPPGQQLGAPDTVLRGIPKGLVHNGGRIAFGPDGMLYAGTGETGNTALAQDRKSLGGKILRMTPDGKPVHGNPEADSVVYSWGHRNVQGLAWDGDKRLWASEFGQHSWDELNLIEPGGNYGWPEVEGKGGKAGFRDPVAVWKTDEASPSGIAWAEGSIWMASLKGERLWRIPLKGAVPAAEPEAFLTGKYGRLRTVVALGGDRLLLVTSETDGRGSPQAGDDRILSLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4S0</accession>
    <name>A0A0F4J4S0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_23405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949546.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5184"/>
    <dbReference type="EnsemblBacteria" id="KJY29245">
        <property type="protein sequence ID" value="KJY29245"/>
        <property type="gene ID" value="VR44_23405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.623"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="453" mass="48441" checksum="64F3070AB3023844" modified="2015-06-24" version="1">MPAKQMLPGRRPSAVKAQGRRRPAAGSGRPARRGPLERLRRTRRQLTKAWDRPLTAYYLIFGSSLLITVLGLVMVYSASMIKALQLGLGDAYFFKKQFLAAAIGGVLLFAASRMPVKLHRALSYPVLAGTLFLMVLVQVPGIGVSINGNQNWISLGGPFMLQPSEFGKLALILWGADLLARKGDKGLLTQWKHLLVPLVPVAFLLLGLIMLGGDMGTAMILGAVLFGLLWLAGAPTRMFAAVLLFAGVIVALLIKTSPHRMDRLACLGATDPGKNDLCWQGVHGIYALASGGWFGSGLGASVEKWGQLPEAHTDFIFAITGEELGLAGTLSVLALFAALGYAGIRVAGRTEDSFVRYAAGGVTTWITAQAVINIGAVLGLLPIAGVPLPLFSYGGSALLPTMFAVGLLIAFAREEPAARAALAMRQPRAGWKRSGPIWKSMRRRVKRRPSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5A2</accession>
    <name>A0A0F4J5A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28096">
        <property type="protein sequence ID" value="KJY28096"/>
        <property type="gene ID" value="VR44_26040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1362"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="23739" checksum="D1C5809B04984555" modified="2015-06-24" version="1" fragment="single">RGPAGTALTAGAVAAGQLSVGWSNDRVDLRRDRAAGRRDKPLATGRVPAAAVTAAALTALALCVPLSLAAGAAAGAAHLAGVAAAWAYNLRLKGTAASWLPYTLAFGLLPAFVTLGLPGAPWPPPWLTGAAALLGAGAHFANVLPDIADDLATGVRGLPQRLGARTSAALAALLVLGSAALLVLGPPGRVTPYGWTLLALTGALLLATAAAPGRIPFLGVMAVAGGDVLLLLARGAGQAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5N3</accession>
    <name>A0A0F4J5N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000638">
        <property type="protein sequence ID" value="KJY29500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29500">
        <property type="protein sequence ID" value="KJY29500"/>
        <property type="gene ID" value="VR44_22790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="15707" checksum="E79F80B22906D403" modified="2015-06-24" version="1" fragment="single">MASVSVEVLAGGGAAAAPYADQLVRHVERSGGAARAAGADLALRALVGMGDDRAADWYAVRLDSPWLDVAPLPSRWAPHLLPVFRRRLVGHGPYDRAVSLILRTLAEWGPAAAPAVPELVGLLDTPVARAAAEALGAIGPAAAGGRRAAGRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5P7</accession>
    <name>A0A0F4J5P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_23760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813788.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene195"/>
    <dbReference type="EnsemblBacteria" id="KJY29088">
        <property type="protein sequence ID" value="KJY29088"/>
        <property type="gene ID" value="VR44_23760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.725"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="25055" checksum="F0076BD560CB8A6A" modified="2015-06-24" version="1">MTRVLVVEDEESFSDALSYMLRKEGFEVAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRGEPEEVTPAALEAGPVRMDVDRHVVTVGGAKVDLPLKEFDLLEMLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5R3</accession>
    <name>A0A0F4J5R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000636">
        <property type="protein sequence ID" value="KJY29530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29530">
        <property type="protein sequence ID" value="KJY29530"/>
        <property type="gene ID" value="VR44_22715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="8678" checksum="AE4C17901DCCC73D" modified="2015-06-24" version="1" fragment="single">MAEEGRTAEAARRTEGEGAGPDALRVGVLAYPGCFASEVFGVPDLLTMAGHVAGPDAPGYRVSVLSPRRRVTASGGTRLDVRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6N9</accession>
    <name>A0A0F4J6N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000639">
        <property type="protein sequence ID" value="KJY29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29489">
        <property type="protein sequence ID" value="KJY29489"/>
        <property type="gene ID" value="VR44_22795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.491"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13069" checksum="86F5AAF01DAE3268" modified="2015-06-24" version="1" fragment="single">LGQPVLRYLADLGPQAAGHADAVRPLLTCPGQWSRVGAAEAWWRITGDAPPAVEALLPELAPLARRSATPLVLRTVRVLGAIGGPAAAALPVLHEVTSSPRRYGGIPADEELLRAARTATSAIEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Z0</accession>
    <name>A0A0F4J6Z0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ORF">VR44_21155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949125.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000588.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7069"/>
    <dbReference type="EnsemblBacteria" id="KJY30137">
        <property type="protein sequence ID" value="KJY30137"/>
        <property type="gene ID" value="VR44_21155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8954"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="370" mass="41119" checksum="786FCBFD09FFAA2E" modified="2015-06-24" version="1">MAVVDVSEELKSLSSTMGSIEAVLDLDKLRAEIAVLEEQAAAPSLWDDPDAAQKITSKLSHLQAEVRKTETLRGRIDDLGVLFDLAQEMDDADTLAEAEAELVSVRKALDEMEVRTLLSGEYAEREALVNIRAEAGGVDASDFAERLQRMYLRWAERHGYPTEIYETSYAEEAGIKSTTFVVKAPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVETSDHVEIDESELRVDVYRASGPGGQGVNTTDSAVRITHIPTGIVVSCQNERSQIQNKASAMNVLQAKLLERRRQEEQAKMDALKDGGSSWGNQMRSYVLHPYQMVKDLRTEFEVGNPQAVLDGEIDGFLEAGIRWRKQQEQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7P6</accession>
    <name>A0A0F4J7P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000689">
        <property type="protein sequence ID" value="KJY28951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949669.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000689.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28951">
        <property type="protein sequence ID" value="KJY28951"/>
        <property type="gene ID" value="VR44_24075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.809"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="42647" checksum="BA7BCB1F400A29A4" modified="2015-06-24" version="1">MQTTIQPVRDDLLRVGGAFTPGFLDPDPSRRLALVGENPFLEFGFNEWRKWEALDDVPAVPEFSLHLGRTAICEGPREQARYIDYVMDQSATRRNKPTSIGVHVTGDRALGGGSFGLHSYFSGTKEEEERAVRFLSDLNRTSGLPVWVENANCYSASARGILDAWQAVTRICEKTGSGLIVDLAHLYIDAVNCGVPVDVLLGAIPWSQVVELHLSGVRTGRDGTLHDGHSEAVHEGVWSLLDTVLDQRLITETEPVTVIVEHADLTWTDRADQYYADFARAESVLERHRRARTGGAADTEPHDYGVPYCRAYLRQLCNGWIPGLAQASEQRGLSYAELFDQWVDDVRARGKRIVLNLDEIPPAERPGAVSAPQDLLAYAKEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7U9</accession>
    <name>A0A0F4J7U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6994"/>
    <dbReference type="EnsemblBacteria" id="KJY30452">
        <property type="protein sequence ID" value="KJY30452"/>
        <property type="gene ID" value="VR44_20385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="7599" checksum="69CD2E35B6ADD9FD" modified="2015-06-24" version="1" fragment="single">MQASGKNAGLGLALVSACAFGGSGVAAKPLIEAGLDPLHMVWLRVAGAALVLSPLAWRHRALVRRRPLLLAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J824</accession>
    <name>A0A0F4J824_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_21625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000604">
        <property type="protein sequence ID" value="KJY29924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949218.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000604.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29924">
        <property type="protein sequence ID" value="KJY29924"/>
        <property type="gene ID" value="VR44_21625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.203"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19777" checksum="4EB3CB898AB8C57D" modified="2015-06-24" version="1" fragment="single">YYRVRYEAPGAPELAASVRALLKAPGTPVQDIPDRGLDHGAYVPLVEMYPGADVPVLQVSLPTLDPARLMDLGRKLAPLRDEGVLIVGSGFFTHNLAALRHTGPGVPGWSAEFDAWGREALAAHDVDALLDFEAKSPAGRLAHPRTEHFAPLFVTLGAAESDLGAQSTPVDGFWMGLSKRSVQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J977</accession>
    <name>A0A0F4J977_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000637">
        <property type="protein sequence ID" value="KJY29506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29506">
        <property type="protein sequence ID" value="KJY29506"/>
        <property type="gene ID" value="VR44_22735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046134">
        <property type="entry name" value="DUF6131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19626">
        <property type="entry name" value="DUF6131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7092" checksum="13F3BEAED05EB40D" modified="2015-06-24" version="1">MVDAGGPPIVRDQEVLMIILGVILLIVGFLTGISIIWTIGVILVVIGLVLWVLGAVGHAGGGRRHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9C4</accession>
    <name>A0A0F4J9C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948778.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30947">
        <property type="protein sequence ID" value="KJY30947"/>
        <property type="gene ID" value="VR44_19235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8453"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470862" evidence="2">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="9910" checksum="13D02DE3E9E9B9BD" modified="2015-06-24" version="1">MDTSDTTRRRMRSGAVALGGMGLLAATLVACGSSSEPDKRCASKSTLEHLNSKECKSGGRGAYYYGGTVSNGKVSGGSFDKSAVTRGGIGGGSHSGSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9K3</accession>
    <name>A0A0F4J9K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948749.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000522.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3415"/>
    <dbReference type="EnsemblBacteria" id="KJY31042">
        <property type="protein sequence ID" value="KJY31042"/>
        <property type="gene ID" value="VR44_19055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8415"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="36"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="185"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="455" mass="48190" checksum="613DF8AA15CB18A0" modified="2015-06-24" version="1">MTFHPRPQAGEAKPWAFPAPERSTLGNGLTLLRCHRPGQQVVAVEVNLAAPLDAEPEGLDGVATIMARALSEGTDKHSAEEFAAELERCGATLDAHADHPGLRVSLEVPASRLPKALGLLAEALRAPAFDDGEVARLVRNRLDEIPHEQANPQRRAAKELSKELFPATLRMSRPRQGTEETVARIDSAAVRAFYEAHVRPATATVVVVGDLTGIDLDAVLADTLGAWTGNTAAPLPVPPVTADDTGRVIIVDRPGAVQTQLLIGRIGPDRHDIVWAPQVLGTYCLGGTLTSRLDKVLREEKGYTYGVRAFAQVLRSTADGKGASMLAISGSVDTPNTGPALEDLWQVLRTLAAEGLTDAERDVAVQNLVGVAPLKFETAASVAGTLADQVEQELPDDYQARLYARLAETGTAEATSAVVSAFPVDRLVTVLVGDAAQIEEPVLALGIGEVTVVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAG6</accession>
    <name>A0A0F4JAG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948668.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31185">
        <property type="protein sequence ID" value="KJY31185"/>
        <property type="gene ID" value="VR44_18675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11134" checksum="B47631787A59EAC2" modified="2015-06-24" version="1">MAEYLLVESQGSYAGPGAEAFLGDAVRLARAGHGVAVLLIENGVTEGLAAAGPAVGRVLAAGGEVWADAFSLDQRALSAQRLAPGVRAVEMDEVAERLLRPGVRGVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB63</accession>
    <name>A0A0F4JB63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000525">
        <property type="protein sequence ID" value="KJY30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30978">
        <property type="protein sequence ID" value="KJY30978"/>
        <property type="gene ID" value="VR44_19125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8429"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7411" checksum="ACBE9D3E381B2F55" modified="2015-06-24" version="1" fragment="single">MADEHKAWLDGATAEELLRGRAAGPAGPGADPRARAEAARLRAALDALTPPSADRELPGEAAALAAFRAAHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBF2</accession>
    <name>A0A0F4JBF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_17965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948534.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000486.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31515">
        <property type="protein sequence ID" value="KJY31515"/>
        <property type="gene ID" value="VR44_17965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="38224" checksum="CEF439794F428539" modified="2015-06-24" version="1">MTASSTTADVPRQRGGDSEAPVLEVRDLHVEFATREGVVKAVNGVNYSVSSGETLAVLGESGSGKSVTAQAIMGILDSPPGRVAKGEILFRGQDILKLPENERRKLRGPKMAMIFQDALSALNPVFSVGNQLGEMFRVHQGMSKKDAKVKAIELMDRVKIPAAKSRVDDYPHQFSGGMRQRIMIAMALALEPDLIIADEPTTALDVTVQAQVMDLLADLQREYNMGLILITHDLGVVADVADKIAVMYAGRIVEQAPVHELYKRPAHPYTRGLLDSIPRLDQKGQELYAIKGLPPNLLKAPSGCAFNPRCPKAQDICRTEMPPLLQVTEQDGTELAGRASACHFREEQLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDZ7</accession>
    <name>A0A0F4JDZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948328.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32024">
        <property type="protein sequence ID" value="KJY32024"/>
        <property type="gene ID" value="VR44_16845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="30533" checksum="DBCCB39B3625D6E7" modified="2015-06-24" version="1">MPVHVGTSGWQYEDWRGPFYPDGLPKRLWLEEYARRFATVENNNAFYRLPETGTFASWRERTPEGFVMAVKASRYLTHVKRLHDPEEPVHRLLEHAAGLGPRLGPVLLQLPPNLRADPAALDACLDCFPGTVRVAVEPRHPSWWDAEPRLRAVLERHGSALCWADRWSRPVTPLWRTASWGYVRLHAGAASPPPRYGRQALDSWARRIADGWPDREDVYVYFNNDQGGAAVADAVRFARSAEAHGRTVTRPPTPRPPTADAPRTRRSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEI3</accession>
    <name>A0A0F4JEI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_18230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948585.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31391">
        <property type="protein sequence ID" value="KJY31391"/>
        <property type="gene ID" value="VR44_18230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470648" evidence="8">
        <location>
            <begin position="29"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="515" mass="53885" checksum="4077A2D06B2F03D9" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEN2</accession>
    <name>A0A0F4JEN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31416">
        <property type="protein sequence ID" value="KJY31416"/>
        <property type="gene ID" value="VR44_18190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8185"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470654" evidence="2">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="18771" checksum="6AA895B6B9840B4C" modified="2015-06-24" version="1" fragment="single">MDVERTPVRRRFLPGIAMLTALVAGATACTGSGGIGGAGDQKNGGSTAAPAQPGKYRSLPQPCKAVDGKRLRAMLPATDSLTTEQREQLYAGTAEPSYDADRHVGCRWNAQTPEATLLLSVTFERVVSYDRAAASDDDKARQVYVRRLTDAHLPFPGPTTSPSPSPSPGTSTGTGTGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFD6</accession>
    <name>A0A0F4JFD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000474">
        <property type="protein sequence ID" value="KJY31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000038_gene4560"/>
    <dbReference type="EnsemblBacteria" id="KJY31701">
        <property type="protein sequence ID" value="KJY31701"/>
        <property type="gene ID" value="VR44_17645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8095"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="89"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="457" mass="50418" checksum="32287757822B84BD" modified="2015-06-24" version="1">MVVDYGAVRLIKKQVGERLTELLRARPGLSQAAQEQQGRHLINEQVAVWSDAEAVKRGVATSPREDALIAQAVFDLQFRAGRLQQHLDNTLVENIFINGYADVWLDFTDGRRVRVAPVADSDEELRELLRDLARRTTGQAERSLSTADPFLALRLADGSRLQAVIDVTPGTYMTIRRHSMRHADLPELVSRGMLDSTLEAFLRACVRAEKNVMIVGGQAAGKTTLLRALLKEIDPDERFATLETEFELFAHENGYHQQVVPMEARESNGEMVAGVAAGEITLMDLMYRALRMTLTRIVVGEVRGPEIVAMLQAMTNGAGGNLCTLHAIHPSVVFDRIAELYLLAQANMSESLAYRQAANGLHFIVFVSSVDETKIGGHRHRFVSHVLEVTGIGEGGRPETNQIFGPRPEWGEHRAVPLMLPRCINDLRRAGFDASLLNTPAGAWGAALPLLVREAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFM6</accession>
    <name>A0A0F4JFM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_15680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948105.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M04.025"/>
    <dbReference type="EnsemblBacteria" id="KJY32604">
        <property type="protein sequence ID" value="KJY32604"/>
        <property type="gene ID" value="VR44_15680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7538"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="88"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="175"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="42380" checksum="F1DF300DDCCA3C12" modified="2015-06-24" version="1">MRTRPINCIIPPYILDKLLESPDSDIRQAALDTLLTTARLRGERAVRASIAGAAATPGDGRRTVFDCDGAASLRGAALARTEDGPASSDTAVNQAFDGLGVIRDFYQEVFHRNSIDDQGMRLDGYVHFDVQFNNAFWDGQQMVFGDGDGQEFSNLAGSLDVNGHEVTHGVTENTAGLEYHNQSGALNESISDVFGSLVKQWKLKQTAEEADWQIGADVWTPGITGDALRSLKAPGQAYNNPQFGKDPQPDRMSKFIHLPDTPRGDSGGVHINSGIPNKAFYLAAVGIGGFAWEGAGRIWYDALRASTADATFQDFADTTYQKAGDLFGVGSSEQAAVLAAWAGVEVQISGVPKARAFAVSGNGAVGREDGLAALSRQLGELNAKVSGLARDIAALKGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFP7</accession>
    <name>A0A0F4JFP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000377">
        <property type="protein sequence ID" value="KJY33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33015">
        <property type="protein sequence ID" value="KJY33015"/>
        <property type="gene ID" value="VR44_14745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7277"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470435" evidence="1">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="19726" checksum="FE6BA3D8173C232F" modified="2015-06-24" version="1">MAGSAALVATLVGAAPAPAAPAAPKVASVHGAGTISYPYVPKEHDIRFTVDAEQVPWSRPFPAQGGEQGMPVDARGKVTVYHAMPDQNFTGVAEAQVDCVVTGGRTAVITAVVTSSNVGWEGKRIGISVQDGEHGAPDRVGFSWGIANVDVQPDGTVAEPHVGTCMAPAPFTEVVKGGFKVTPAPLAPRPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFR1</accession>
    <name>A0A0F4JFR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_14410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947876.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3322"/>
    <dbReference type="EnsemblBacteria" id="KJY33177">
        <property type="protein sequence ID" value="KJY33177"/>
        <property type="gene ID" value="VR44_14410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7231"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="22921" checksum="CE143CD152985025" modified="2015-06-24" version="1">MLNKYARAFFTRVLTPFAAFLLRRGVSPDAVTLIGTAGVVAGALVFFPRGEFFWGTITITLFVFSDLVDGNMARQAGVSSRWGAFLDSTLDRVADAAIFGGLALWYAGSGNDNVLCAVAIFCLASGQVVSYTKARGEAIGLPVAVNGLVERAERLVISLVAAGLSGLQTFGVPSWIGVLLPIALWVVAAGSLVTLVQRVVTVRREAAEADAAAPAEGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG57</accession>
    <name>A0A0F4JG57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948024.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000395.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32743">
        <property type="protein sequence ID" value="KJY32743"/>
        <property type="gene ID" value="VR44_15240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7384"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12165" checksum="5296B455237CB5EC" modified="2015-06-24" version="1">MAPLARIPLEGGGFVLVEASPATDGPVKAGRIGDAVRVLPETLQEALAPVTAAARVALDQLRKARPDDITVQFGIDLSVAAGAVITKTGAGCHLTVTMTWKGSDSGRPPAASEPPERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGL6</accession>
    <name>A0A0F4JGL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_14895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000382">
        <property type="protein sequence ID" value="KJY32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947959.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000382.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32934">
        <property type="protein sequence ID" value="KJY32934"/>
        <property type="gene ID" value="VR44_14895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7395"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="602" mass="63057" checksum="F75691C02442D7CD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGL9</accession>
    <name>A0A0F4JGL9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32913">
        <property type="protein sequence ID" value="KJY32913"/>
        <property type="gene ID" value="VR44_15035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7426"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470715" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15306" checksum="87636766E32A1C7F" modified="2015-06-24" version="1">MTTVLAAAAALSAAVTTSATAADAGELKNLRTGACIDDSSLGLRGFGCNGLSYQMWLNYGSGNGNTVLKNANTGRCLDDSGAGLRAIPCNGLNYQNWRATLDTVKWAWTFQNENTGRCIDDSSAGLRSFPCNGLSYQKFYYQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH93</accession>
    <name>A0A0F4JH93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947887.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33123">
        <property type="protein sequence ID" value="KJY33123"/>
        <property type="gene ID" value="VR44_14455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7152"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470731" evidence="2">
        <location>
            <begin position="28"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="22364" checksum="AB4888AF9A9E8BAC" modified="2015-06-24" version="1">MIMRRTAVTLAGLAFFTAALVGGCGTAASGPGAPAPLPPSGPAAACPVLDRAAHTAPPATVGGTPVNTPEAARLSQAVGAQGRGAFADVYGAQITDHPAGRVALCVTDLGRGRLLLEAARKADPAVDPGRADLYLSRYTRRALNEGVARLTADQGRPLFPLYSFSPAPDASGIVVTSTAEGAASKDLKARLEQLTGGIPVTVERGDPLTPAVGGPSADAGDPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHH0</accession>
    <name>A0A0F4JHH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947671.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene701"/>
    <dbReference type="EnsemblBacteria" id="KJY33797">
        <property type="protein sequence ID" value="KJY33797"/>
        <property type="gene ID" value="VR44_13275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6874"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="46704" checksum="42FBE37F72786100" modified="2015-06-24" version="1">MTAVPQERRIVTAIPGPKSQELQARRLSTVAGGVGSVLPVFTARAGGGIIEDVDGNRLIDFGSGIAVTSVGASAEAVVRRASAQLADFTHTCFMVTPYEGYVEVCEALAELTPGTHAKKSALFNSGAEAVENAVKIARAYTKRQAVVVFDHGYHGRTNLTMALTAKNMPYKHGFGPFAPEVYRVPVAYGYRWPTGAENCGPEAAAAAIDQIAKQIGAENVAAIIIEPVLGEGGFIEPAKGFLPAIVKFANENGIVFVADEIQSGFCRTGQWFACEDEGIVPDLITTAKGIAGGLPLAAVTGRAEIMDAAHAGGLGGTYGGNPVACAGALGSIETMKELDLNAKAKNIESIMKSRLSAMQEKYDIIGDIRGRGAMIAIELVKDPASKTPFPEAAGALAKACHAEGLLVLTCGTYGNVLRFLPPLVISDELLNEGLDLIEAAFAAIGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJE9</accession>
    <name>A0A0F4JJE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dGTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000327">
        <property type="protein sequence ID" value="KJY33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947614.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000327.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33919">
        <property type="protein sequence ID" value="KJY33919"/>
        <property type="gene ID" value="VR44_12965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6710"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14719" checksum="095C4DE099CB83DB" modified="2015-06-24" version="1">MKAAVRKWEAVRAFALGLPEAVEEHPWGPEDGVVKVNKKIFVFLGNADGPEPPGLSVKLKDEALHGHALTAPGARPTGYGLGRAGWVSVPLGEKGAPSAEVLCEWVEESYRTVALKRHVRELDSRRPGGAPVEIGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJM1</accession>
    <name>A0A0F4JJM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-formimino-L-glutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000321">
        <property type="protein sequence ID" value="KJY33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947590.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000321.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene491"/>
    <dbReference type="EnsemblBacteria" id="KJY33999">
        <property type="protein sequence ID" value="KJY33999"/>
        <property type="gene ID" value="VR44_12845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6652"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="46525" checksum="2E59AF15BD6FB0BD" modified="2015-06-24" version="1">MTAQKTYWLEHAWLGEHVEPGVALDVTADGRIAGLRTGADTPPPGAEVLRGLTVPGLANAHSHAFHRALRSTVQVGSGTFWTWREVMYGVAQNLTPDSYFDLARAVYAEMALAGITDVGEFHYVHHAPGGTPYADPNAMGEALIEAAAAAGIRITLLDTAYLAAGFGEAPNAHQRRFSDGTADAWAERVSALKPREHALIGAAVHSVRAVPAGQLATVAAWAQERQAPLHVHLSEQTAENDACLAAHGRTPAQLLADHGVLGPGTTGVHNTHLTDEDIALLGATTTGTCMCPTTERDLADGIGPAGRLQRAGSPLSLGSDSHAVIDLLEEARAMELNERLRSRTRGHWTANALLTAATADGHAALGRPDAGRLEAGALADFTTIALDTVRTAGPLPRLGAETAVFAASAADVRHTVVGGRHIVRDGAHTLVGDVAGALSEAIAAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLK4</accession>
    <name>A0A0F4JLK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000236">
        <property type="protein sequence ID" value="KJY35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35227">
        <property type="protein sequence ID" value="KJY35227"/>
        <property type="gene ID" value="VR44_10600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="22228" checksum="BA37FE8DCCEA01F8" modified="2015-06-24" version="1" fragment="single">ASGGSSTGASAPACGPDGAVKAAGAGSLKVAMDRWVADYQAACPGTRADYAPTGAGAGIQQFKEGSADFAVVDRLLTPAQTESVAARCPGGRPVQLPLGVLPVAVVVNLPGVDALTLGPATLARIFRGQITRWNHAEIAASNPGRPLPDTAIQVVTPTDESTTTLTFTQYLSTVVPTGWGSIPESSLSAVGTGPGVSSSAVARTVKQTAGSISFTRPGAEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLT2</accession>
    <name>A0A0F4JLT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_11335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947308.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000123_gene6820"/>
    <dbReference type="EnsemblBacteria" id="KJY34779">
        <property type="protein sequence ID" value="KJY34779"/>
        <property type="gene ID" value="VR44_11335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6162"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="297"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="498" mass="52774" checksum="DB5B7B8AAD7F461A" modified="2015-06-24" version="1">MNRTRTNGRSSLTRNRTGGPVFRTAAGSEQGSRFGASAPSRSGGYGRRPAAVQGEFALPKTITPALPAAEAFADLAMPGELSAALTAQGLTVPFPIQGATLPNTLAGRDVLGRGRTGSGKTLAFGLALLARTAGERAEPRQPLALVLVPTRELAQQVTDALTPYARAVKLRLTTVVGGMSIGRQAGALRAGTEVVVATPGRLMDLIDRGECRLNQVAVTVLDEADQMADMGFMPQVTALLDQVRPEGQRMLFSATLDRNVDLLVRRYLTDPVVHSVDPSAGAVTTMEHHVLHVHSADKQRTTTEIAAREGRVMMFLDTKHAVDRLTEDLLNSGVRAAALHGGKSQSQRTRTLAQFKTGHVTVLVATNVAARGIHVDNLDLVVNVDPPTDPKDYLHRGGRTARAGESGSVVTLVTPNQRGGMTRLMRAAGITPQTTQVRSGEEALNRITGSQAPSGVPVVITAPVLERAARVAASRGRRRPAATVRRVDVRQSAFDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLV1</accession>
    <name>A0A0F4JLV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000239">
        <property type="protein sequence ID" value="KJY35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947186.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000239.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35175">
        <property type="protein sequence ID" value="KJY35175"/>
        <property type="gene ID" value="VR44_10670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5881"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="27396" checksum="45AF649529864DC4" modified="2015-06-24" version="1" fragment="single">TVRRVGETIRRPAGAWTPAVHALLAHLESAGFTRAPRALGTDGGDEVVSLLHGEPAYSPWPSVLRSTAGVRELGTWLREYHEAVRDFRPPADARWRGQEDEEWRPGLIVRHGDLGPWNSIWHGDRLAGFIDWDFAAPGHALDDLAQLAWYAVPLRPAEKQRRESITGDHALRSRLDALCAAYGARPAAVLDALDAVQSREAARIERLGGRGQEPWATFLARGDAEEMRAERSWLRSNRTLLLGTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPE6</accession>
    <name>A0A0F4JPE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000182">
        <property type="protein sequence ID" value="KJY36050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36050">
        <property type="protein sequence ID" value="KJY36050"/>
        <property type="gene ID" value="VR44_08780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10327" checksum="05BAF0425CC8CA4C" modified="2015-06-24" version="1" fragment="single">MSAGDRPAEPGVPRLRLDELLDELQIRIEEVRGTRDRLNGLLEAVMSVGRELDLPQVLRGIVEAAVLLVDAEYGALGVIGDDRSSPSSCPSASATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQU2</accession>
    <name>A0A0F4JQU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000143">
        <property type="protein sequence ID" value="KJY36732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946558.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000143.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36732">
        <property type="protein sequence ID" value="KJY36732"/>
        <property type="gene ID" value="VR44_07315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3934"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471156" description="GH26 domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="53801" checksum="16B921537152A94E" modified="2015-06-24" version="1">MPRPHHRLVSTCVGTVTAGLLATGAALAAPDDDPAKGSDTAFGAYLDYGPSGIARIPRLSRWLGGREVRVGHTYLPGDSWAGIEGRVPFLEDWAQWRRAEDDRMFVLNVPMQARNEGRVPDWQVAQLIRAGAQGEHDKHFRRLAERLVELGVPDTVIVLGWEMNGTTYTHRCGPDPEHWKAYWNRVVNTMRSVPGQRFKFDFTPNRGTDAIPWTECYPGDDVVDVIGMDSYDQGPGRTFDDHVRQPYGLQQHVDFAKAHGKRISYPEWGLFRNGDNPEYVRRMLQWIDQHHPLYHTITDYCPHGVWQCKQNPRSSKVFRDALSDQGPVVVPTPVVPTPVVPTPVVPAPVVPTPVVPTPVVPTPAVPTPQLPTPEVPTPSAPTPDAPTPTPTPTPEATPSPTPTPVAPEPQPLPTRPAPSVSQPPKPQPTKPQPTKPEPKPQPQQPVNSKQWCLPLDFGDWFSKLMGKQQVCITFGGWGGDSGFWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR45</accession>
    <name>A0A0F4JR45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VR44_08190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="JZWV01000166">
        <property type="protein sequence ID" value="KJY36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946726.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene271"/>
    <dbReference type="EnsemblBacteria" id="KJY36319">
        <property type="protein sequence ID" value="KJY36319"/>
        <property type="gene ID" value="VR44_08190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4388"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="39332" checksum="705AAE67730B2C34" modified="2015-06-24" version="1">MTTPTIELKPSSNPLSDAEREAILASPGFGRHFTDHMVTIKWTEGRGWHDAELVPYAPLSIDPANMTLHYAQTIFEGLKAYRQPDGTVATFRPQANAERFQASARRMAMPELPTELFIEACDALIKQDSAWVPTSGEASLYLRPFMFASEVGLGVRPANEFLFMVIASPAGAYFPGGVKPVSVWLSEEYVRAVKGGTGAAKTGGNYAASLVAQAQAASHGCDQVVWLDAVEHRWIEEMGGMNLYFVYGDRIVTPELTGSLLPGITRDSLLTIARDLGYTAEEGRISTEDWKRDNENGTLTEVFACGTAAVITPVGSVKSERANWTQGDGEPGEVTMKLRKALLDLQTGHRADTHGWMHPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS25</accession>
    <name>A0A0F4JS25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000201">
        <property type="protein sequence ID" value="KJY35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35756">
        <property type="protein sequence ID" value="KJY35756"/>
        <property type="gene ID" value="VR44_09260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5179"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10345" checksum="6D81F8BFCB90708C" modified="2015-06-24" version="1" fragment="single">AHHLLSIAAEALENARRHAHATRVTLTAATTPTHLTLTVTDDGPGLPPGGPPSTRRGHYGLLGMRERAAALGADLRLGPRPDGTRGTRVHLTLPLEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSK1</accession>
    <name>A0A0F4JSK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946395.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37150">
        <property type="protein sequence ID" value="KJY37150"/>
        <property type="gene ID" value="VR44_06410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3194"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="17985" checksum="3533C3DF0AE2F954" modified="2015-06-24" version="1">MDLIEFTHAVTRAGAGFGFFLVVVTAAAVFYGNGRTVNALKKRRIWLPWVSSFAVMVLASAVSGGFLSKVSAGFTGTSNRVGSEVGNTAIGQSGEGAVEIHVTEVLSYSGSWIALCAVVVWLLFLWFAKGWGERALALSGALSGASWGIATSLGGAAAMIGVPLVSWLGEQVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVT9</accession>
    <name>A0A0F4JVT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946408.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37086">
        <property type="protein sequence ID" value="KJY37086"/>
        <property type="gene ID" value="VR44_06475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3208"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="31827" checksum="F4F2E1EFF074DF55" modified="2015-06-24" version="1">MTTELALGTYHCRDIPRAAAHAVARGAHWIDTAPNYRAGRAHTQLAAVLTQHPQVKVSTKTGFFGKDEATAAVAEGILTWHQAAAGHSLTPEFLRWQTSRSLDLLGRADLVFVHNPEHARLDRKELHQRLREAFIVLEDFAHTGRIGGYGVATWSGLDTAEFSVTELLALAREAAGGHHHLHAVQLPVSLVMARPISLALDGRGPLVQARAAGLDVFASSPLHGGQLPGMVTAELAEVIEPGLTPTQAALRIVASTPGVTRVLLGTSNPAHWDAAQQTLALDPLPPSTLRKVLDVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWI7</accession>
    <name>A0A0F4JWI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945985.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38103">
        <property type="protein sequence ID" value="KJY38103"/>
        <property type="gene ID" value="VR44_04185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.126"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34137" checksum="71C95C700ED60FF0" modified="2015-06-24" version="1">MTATASASASDTTADTADAVPAAAHFRFFTLEVLRTRRLGHSFLRVTFGGESLAEFRSGGYDQSLSLFLPVGEQEHTELPSTDEDTWFGAWRAMPDGIRPVMRSYTVREQRRTDGGEVEVDIDFVLHGDSSPASRWAGRAAAGRRIMAIGPAVAENKSVRFQRPEGCDAVLMYADETALPAAAAILDRLPAGTRVKAWFEVPHEDDRLGPHTLADTDITWIVREKAAGAAARTERVLSELRAARLPGAGAPYAWLAGEAGTVRAVRRHLVQERSVDRRAVRFTGYWRLGASEEQLLAEAYAGKAPSEDPTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX84</accession>
    <name>A0A0F4JX84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">VR44_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945884.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38434">
        <property type="protein sequence ID" value="KJY38434"/>
        <property type="gene ID" value="VR44_03615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8261"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="23262" checksum="4BB830D3A64E7739" modified="2015-06-24" version="1">MAQQENQVTPIDDEGWVVDTEDCEARELAYREAGTSRPITVVGNPVLHRECKDVTEFGEELAQLINDMFASQKTAEGVGLAANQIGVDAKVFVYDCPDDDGVRHTGVVVNPKLVELPAGSRVLDDSNEGCLSVPTAYASLARPDYAEVTGQDAQGNPIKVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAENTPRYPVVAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYD5</accession>
    <name>A0A0F4JYD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945615.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39140">
        <property type="protein sequence ID" value="KJY39140"/>
        <property type="gene ID" value="VR44_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41325" checksum="60758FF23EA08450" modified="2015-06-24" version="1" fragment="single">MSLASPPAASPAIASPSVASVLAESAARRPAHPALVFGDRSYSYAELWDGALRYAAALRARGLGAGDRVALLLPNTPAFPMAYYGILALGCTAVPVHEQSRAPEISHVLRDSGAAALVCAASLLPEAAAAARAAGVAVLGVSDGDATGDDGDADAAGPDLAEQLPRLDREARHAEPLPGLVPPAPGAIAVVLYTSGTTGAPKGVMLTHHNVLMNITTTARTPFAFDGHDVLLGALPLSHTFGQICGMGVCFHAGATLVLMSRFCGTRALELMNDHRCTVVMGVPTMYLALLDAAGSDPRRPPLERAYSGGSSLPPAVLRQVEEVLGAPVYEGYGLTETSPSVSYNQPGHRRRPGTVGLPIPGVEVGIADADEPRRIRLLPDGERGEIVVRGHGLMAGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ45</accession>
    <name>A0A0F4JZ45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000040">
        <property type="protein sequence ID" value="KJY38973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38973">
        <property type="protein sequence ID" value="KJY38973"/>
        <property type="gene ID" value="VR44_02585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6821"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="38933" checksum="48D91825808B0385" modified="2015-06-24" version="1">MSRMTDVPPHGGQPSPPLPRVRLVDVAREAGLSKTTVSAALNGTGRLSPEVREKARETARRMGYRPNATARRLRAGRARLIGYVVGEFADAPWTFLESPYFARLTAATAATSLRRGYAVVLLPAGSLQSEWADLSLDAVVVADPVADDPIVEDLLAARIPVFSDRSVEGRPGAYWVDVDAGAAVREALDHLRAQGARRPVLLVPDSTTRFHTEVFAAHRAWCAEHGVPERVVRVGAPGNGPVIRAVETALADDPAAAGARPDALLVVAEASPPLVLDAARRLGYEVPGDLLLVCVSEDVTAEHTEPPVTTLSLRPEAIAEAGVETLVAVLEHGDREAAGVLVRTRLDVRASSVRPAQSECTSRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ94</accession>
    <name>A0A0F4JZ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945658.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39033">
        <property type="protein sequence ID" value="KJY39033"/>
        <property type="gene ID" value="VR44_02430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6776"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="10098" checksum="6A30AA80F9E06721" modified="2015-06-24" version="1">MSHVTEWKTRIYLFEEDRTTHVRIDLDTGTTKLTGHGTARCNPTDADVPEIGDELAAARALEDLGAQLKLLAFGDMETAGAGPRAGTPWATASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZM6</accession>
    <name>A0A0F4JZM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945891.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5770"/>
    <dbReference type="EnsemblBacteria" id="KJY38441">
        <property type="protein sequence ID" value="KJY38441"/>
        <property type="gene ID" value="VR44_03660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8270"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="28051" checksum="9C1FD23BDA16A2C4" modified="2015-06-24" version="1">MSTEGATTEPEGGPATRTARVPKYYRLKRHLLDMTETLPPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQPLQLSSYTEDMRAQGLEPTSQLLDIGYVTADDTLAGLLKIATGGRVLRIERLRLASGEPMAIETTHLSAKRFPALRRSLAKYTSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSLDADGEPVEWVRSVYRGDRYKFVARLQRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZV7</accession>
    <name>A0A0F4JZV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_00860</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945376.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4772"/>
    <dbReference type="EnsemblBacteria" id="KJY39670">
        <property type="protein sequence ID" value="KJY39670"/>
        <property type="gene ID" value="VR44_00860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2881"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY39670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="40619" checksum="51615CD1DE160304" modified="2015-06-24" version="1">MDTIASLFSFITTPVSWVIVQFHSLYGAIFGPDSGWAWGLSIVSLVVLIRICLIPLFVKQIKATRGMQALQPKMKAIQERYKNDKQRQSEEMMKLYKETGTNPLSSCLPILAQSPFFFALYHVLSAIANGQTIGVINQSLLESARQAHIFGAPLAAKFTDSAEKAASLGASITDVRIVTAVMIVLMSLSQFYTQRQLMQKNVDLSVKTPFMQQQKMLMYIFPVIFAVMGINFPVGVLVYWLTTNLWTMGQQMYVINQNPTPGSKAQDQYLTRLLKHVSTHGNVKGRGKKKIVAAIVAKGPDRNDNERKFITALSKQGMAAQADGSVIRSSEATADADAASGGVATKRQQPKRQSKSKRQTPPSKPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZV8</accession>
    <name>A0A0F4JZV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">VR44_03415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945851.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6624"/>
    <dbReference type="EnsemblBacteria" id="KJY38541">
        <property type="protein sequence ID" value="KJY38541"/>
        <property type="gene ID" value="VR44_03415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7900"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="801" mass="81420" checksum="E2CE11587BFB7C54" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K062</accession>
    <name>A0A0F4K062_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945788.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38636">
        <property type="protein sequence ID" value="KJY38636"/>
        <property type="gene ID" value="VR44_03075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7830"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="3">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="116"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="27361" checksum="4987B7BBF2B97A4A" modified="2015-06-24" version="1">MPGGRLTQSERQQIALGLADGLAYAEIARRLDRPTSTVTREVMRNGGPASYRADLAHRATEHRAHRRKQAAPRGPEAPPPAHGRDPEAVAAYEETFTTVLIATGTPKMMARVMTCLYTSDSGSLTAAELVQRLQVSPASISKAIAFLETQGLVRRERDERRRERYVCDNDVWYQSMIASAKGTAQLAETAREGVGVLGPQTPAGVRLENIARFVDFVSESITRAAEQAREILHTKPEAEAGPEGSEGPDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K197</accession>
    <name>A0A0F4K197_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_00690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4805"/>
    <dbReference type="EnsemblBacteria" id="KJY39693">
        <property type="protein sequence ID" value="KJY39693"/>
        <property type="gene ID" value="VR44_00690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2844"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="22900" checksum="B8A57A157D80427E" modified="2015-06-24" version="1">MTAKVIRVVIADDEPLIRAGIRMILTSAPDIEVVAEGANGREAVELARSHAPDVVLLDIQMPVMDGLTALGELGRAVPGARALVLTTFGEKENVLRALGQGSAGFLLKDSAPAELIGAVRAAAAGDAYLSPAATRHVVDQLATGRAAGRGEEARRRVAALSERERGVLALLGEGLSNADAGRRLHMSEATVKTYVSRILAKLECENRVQAALLARDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1V4</accession>
    <name>A0A0F4K1V4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ORF">VR44_00170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945273.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene999"/>
    <dbReference type="EnsemblBacteria" id="KJY39913">
        <property type="protein sequence ID" value="KJY39913"/>
        <property type="gene ID" value="VR44_00170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.31"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10407" checksum="F87D7985C4972D56" modified="2015-06-24" version="1">MTDALGSIDMPDADSDTREKKARKGGKRGKKGPLGRLALFYRQIVAELRKVVWPTRNQLTTYTTVVIVFVVIMIGLVTVIDYGFQEAIKFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3E6</accession>
    <name>A0A0F4K3E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945360.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39706">
        <property type="protein sequence ID" value="KJY39706"/>
        <property type="gene ID" value="VR44_00760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2857"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="27401" checksum="442029F9AF75C0F7" modified="2015-06-24" version="1">MTNSDDSSAGPRRRVRTVRLLTAAVFALAGLIFVTSFNTSKGTNIRTDASLLKLSDLIHERSANNAELEKSAAAVRSQVDALADRDNGSTKAEDAKLAALRKASGTEELTGKGLSVTLNDAPPNATARVPGVPEPQPNDLVIHQQDLQAVVNALWLGGAEGIEVMGQRLIATSAVRCVGNTLILQGRVYSPPYKVSAVGDPGALRKALNNSPAIQNYQLYVNAYGLGWKVEEDKRLTLPGYSGTVDLHYAKPLESASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2P3</accession>
    <name>A0A0F4I2P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001768">
        <property type="protein sequence ID" value="KJY16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16275">
        <property type="protein sequence ID" value="KJY16275"/>
        <property type="gene ID" value="VR44_40525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6902"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17489" checksum="C908D48EC15A58D5" modified="2015-06-24" version="1" fragment="single">AAKVRGWVPWVVAAALLVPAGVWSAWLRTPESRRDDVLAVAAAVREEGRPGDAVLFMPSRRREWLLSSPQLYGGLRDVALAASPAASHTLHGTELPPERVRQALLSSPRVLALMDPADQPLDPYPAEAEKRDTLTADFDRCSVTEVRGARVAVYARRGGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9H8</accession>
    <name>A0A0F4I9H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001593">
        <property type="protein sequence ID" value="KJY18710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18710">
        <property type="protein sequence ID" value="KJY18710"/>
        <property type="gene ID" value="VR44_39480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5985"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY18710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14805" checksum="0601F461DAEAB855" modified="2015-06-24" version="1" fragment="single">AVRPGQALRDLGFDSLTAVELRNRLGKDTGLRLPPTLVFDYPTPAELAAYLGAEAAPAGRDVTGLLAELDRIEAELQNTATADADLRESVTGHLRRLLDRWAAPAGQAAETEVSGVADGLHTATDDEMFDFIGKEFGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBL0</accession>
    <name>A0A0F4IBL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001578">
        <property type="protein sequence ID" value="KJY18878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18878">
        <property type="protein sequence ID" value="KJY18878"/>
        <property type="gene ID" value="VR44_39340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="12989" checksum="9E2ACCD4EBB2C04C" modified="2015-06-24" version="1" fragment="single">GVPVDPRGLLPAEERRLLDLPPAELDTQSYWVPGKRPAPPRRTAPVPVPAPVPPAEPPADETPYELLRMIRHQAALLTHLTNALPTPRPAPGEAADATAAAPAVNAQAATPAGTSPAADTSDAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEG4</accession>
    <name>A0A0F4IEG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_38855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001522">
        <property type="protein sequence ID" value="KJY20064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000033_gene6717"/>
    <dbReference type="EnsemblBacteria" id="KJY20064">
        <property type="protein sequence ID" value="KJY20064"/>
        <property type="gene ID" value="VR44_38855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5486"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="5">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14973" checksum="2E7A16975AA32B71" modified="2015-06-24" version="1" fragment="single">DAFAALLAGERRQIKGVLRDQAVIAGIGNAYSDEILHAARVSPFKLAASFDEEQVTHLYEAVRETLRAAVERAHGLAAGQLKAEKKSGLRVHGRDGEPCPVCGDTVRSVSFADSSLQYCPTCQTGGKPLADRRLSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH51</accession>
    <name>A0A0F4IH51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001457">
        <property type="protein sequence ID" value="KJY21380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21380">
        <property type="protein sequence ID" value="KJY21380"/>
        <property type="gene ID" value="VR44_38285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5266"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="18259" checksum="B3484C4561E1A358" modified="2015-06-24" version="1" fragment="single">FTAEGTALAPGGPLRYPATGTVPTPPPAPTRDSYLSDLDWISAANGWGPVERDASNGKSAAGDGPPISFGGTSYPKGLGVHAPSDIAYHLGGAAVRFTSLVGIDDFSAKQSSLGATRAKVYGDGRLLLTTPTLTAAGGPVAVDLDVRGVRVLRLVVEDANNRTSFDHTSWALARVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INX5</accession>
    <name>A0A0F4INX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001379">
        <property type="protein sequence ID" value="KJY23727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952138.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001379.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23727">
        <property type="protein sequence ID" value="KJY23727"/>
        <property type="gene ID" value="VR44_37465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="40986" checksum="C7A3A1D417130D8E" modified="2015-06-24" version="1">MHEAEAEAEEVDRVVRAPEGTVHKVVKSLWIAIWLFYLSAPVTDLVRGGHSDGARLLGGLGLLAFVGWYLVLVFRPDRQKPVRPVLLSLAVLSAVATALSLALGREWLVLFVYVSIASGAALPAQISRFTVPAATALLTALALTVPDGGDYLWGLLIPALMGGFAMVGVRAMIRTTIELRQARATVAQLAANEERLRMARDLHDLLGHSLSLITLKSELAGRMLPDHPDRAAQQVADIEKVCRQALVDVREAVSGYRRPTLPGELAGARTALAAAGVKGDLPSDFTDTVPEDQECALAWSLREAVTNVVRHSGAKRCTVALTTRQTLAGPVLELSVTDDGSGGSAVPGNGLTGLTERLEAVGGTLWAGPAGKTGFRLLARVPLGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INZ4</accession>
    <name>A0A0F4INZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001370">
        <property type="protein sequence ID" value="KJY23755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23755">
        <property type="protein sequence ID" value="KJY23755"/>
        <property type="gene ID" value="VR44_37365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4891"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="107"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24023" checksum="02F61967BFC28A87" modified="2015-06-24" version="1" fragment="single">LSMRASDADRERVVERLRDAVAEGRLDMEEFEERLEAAYKSRTYAELEPLTRDLPAPESSSALSYAPGPVSATSSSWQSRIGGTSASSSAVAIMSGFQRKGRWTVPAQFNAVAFWGGGELDLREADFAAREVVITCVAIMGGIEITVPPGVEVDVRGIGIMGGFDQGRSLENRPEPGAPRVVVNGLAFWGGVAVKVKAPKPPKQPKRLKDGRKPVDGEVRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPJ9</accession>
    <name>A0A0F4IPJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001329">
        <property type="protein sequence ID" value="KJY23927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952026.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001329.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23927">
        <property type="protein sequence ID" value="KJY23927"/>
        <property type="gene ID" value="VR44_36840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4680"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18579" checksum="5B5DAE90C4C68ABC" modified="2015-06-24" version="1">MYGTVTQPKRYKQSAGLLLFRRRGAGADGRDGGVEVLLGHMGGPLWAGRDAGGWAIPKGEYGPDETPRDAARREFTEELGLPPPEGEYLPLGEVRLSSGKLVTIWAVEGDLDPALVVPGTFTMEWPPHSGTEREFPELDRVAWFGPPMARNKLIASQVPFLDRLLTLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPT0</accession>
    <name>A0A0F4IPT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001313">
        <property type="protein sequence ID" value="KJY24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24007">
        <property type="protein sequence ID" value="KJY24007"/>
        <property type="gene ID" value="VR44_36590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4626"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14876" checksum="7AEA8ECB06097CAD" modified="2015-06-24" version="1">MRPLSAHAPRPCTLVVCRGCCCGDPRKNPGTDHAGQLARLREAADASGGRLAVRTSECLGPCERANVIVVQPTTEARRRGARAVWFGWALDDTATDEIIAWAESGGPGATPLPATLDLHRIDPPEPKPATPAPRRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPZ6</accession>
    <name>A0A0F4IPZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001299">
        <property type="protein sequence ID" value="KJY24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951939.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001299.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24072">
        <property type="protein sequence ID" value="KJY24072"/>
        <property type="gene ID" value="VR44_36390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4530"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="468" mass="48838" checksum="CB0B8A61B2329CF5" modified="2015-06-24" version="1">MFLGAARQAELVREGKVTARALAEASLRRIEALDPQLGAFRVVRAREQVLAEADARDAARAAGAELPLLGVPVAIKDELDVAGEVTTFGGAANLTPAARDSEAVRRLRAAGAVVVGKTAMPEFGQWPFTESAAHGRTRNPWDTSRTPGGSSGGSAAAVAAGLVGAALGGDGGGSIRIPAACCGLFGLKPQRGRVPTAPQPHLWHALGTIGPLTRGVRDSALLYDVLSGPAEGDRWAARPTATGFVRAASTEPGRLRIAWSAKPAVPGVRPHPEHVTALRRTADLLRELGHDVREVSPRYPDATAAFVPQFCGGVRAEAAAVERPELLEHRTRQTLRLARLAPEAAVERAVRAGERLTERAERVFAGADLLLTPTLAARPRAVGALDGVGLVGLLGALLRSRPMIAYTALWNVTGHPAASVPAGFGTDGLPLAVQLVGRPHEEPALVSVAAQLESARPWTLRVPPLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQJ6</accession>
    <name>A0A0F4IQJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001256">
        <property type="protein sequence ID" value="KJY24277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951833.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001256.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24277">
        <property type="protein sequence ID" value="KJY24277"/>
        <property type="gene ID" value="VR44_35830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4322"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="624" mass="66962" checksum="3058C1ACFC50D8A0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR34</accession>
    <name>A0A0F4IR34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001328">
        <property type="protein sequence ID" value="KJY23933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23933">
        <property type="protein sequence ID" value="KJY23933"/>
        <property type="gene ID" value="VR44_36825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4677"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23322" checksum="96C36E46B1D78477" modified="2015-06-24" version="1" fragment="single">LILTIGGVLTGAANAVRELVKERVIYQRERAVGLSRSAYLMSKVVVLGTITVAQAVVLTLIALAGVDLNAPGGKGVLMPPLIEITIAVALLSFTAMMLGLMISALVKKEEVTMPLLVLLAIVQVVFCGTLLKLYGVPVLEQVAWLAPSRWAMGAMGATLQLGRIVPGKLTQDPIYHHESGIWLVCIGALVALSVAYGLVVARLLRRQEPAVMRKQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR97</accession>
    <name>A0A0F4IR97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_35065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001207">
        <property type="protein sequence ID" value="KJY24545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24545">
        <property type="protein sequence ID" value="KJY24545"/>
        <property type="gene ID" value="VR44_35065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="23436" checksum="D738C6563C3063B6" modified="2015-06-24" version="1" fragment="single">GLPAAAIAWGSWGSGRMMGRHAEEHLTRRGILPMPADLGIAALRRAMENEDTVVTVADIDWERFVRAFAHTGDYPLLHRLPEARRILEAAAPAGATGTAEGGSPLTGRLAGLPGPERLRALVELVRTQAATVLGHAGADAVQPQRAFRETGFDSLTAIELRNRLAGATGLRLPTTVVFDYPTPAELAAHLDAQLAGGPRPGAPATAPAARPADDEPVAIVAMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRR6</accession>
    <name>A0A0F4IRR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001242">
        <property type="protein sequence ID" value="KJY24359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951792.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001242.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24359">
        <property type="protein sequence ID" value="KJY24359"/>
        <property type="gene ID" value="VR44_35615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4243"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="30987" checksum="B74994401F33E7E8" modified="2015-06-24" version="1">MEAVSRTAQWTAAARALETDREDRLFADPYARTVADTIGFELLERYAGAGTVPFLAIRTTYLDRQIVRTVQEHGIRQVVFLAAGMDTRFYRLPWPDGVTVYELDRPALLEAKAEMLAGEPQPAGRTRTAVPVDLTQDWTGPLKEAGWRSDEPVLWVVEGLLFFLPELAVRNLISTLAGHSAPGSVLLGDVISKAALENPLSRPFLKCLEEDGNPWLFGTETPEQLLADCGWDVREVRQPGEDGAHFDRWPYPVPARTVPGVPRSFLFTCDLPTTEVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS23</accession>
    <name>A0A0F4IS23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ORF">VR44_35345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JZWV01001227">
        <property type="protein sequence ID" value="KJY24444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951743.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001227.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5006"/>
    <dbReference type="EnsemblBacteria" id="KJY24444">
        <property type="protein sequence ID" value="KJY24444"/>
        <property type="gene ID" value="VR44_35345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4181"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="31148" checksum="908FC6A9CF3DD1D6" modified="2015-06-24" version="1">MSGQSLLVPGELSPARSVPGNIRRPEYVGKPGPKPYTGPEVQSAETIEAMRIAGRIAAQAMEEAAKHIAPGVTTDELDRVAHEYMCDHGAYPSTLGYRGFPKSLCSSLNEVICHGIPDSTVLRDGDIVNLDVTAYIGGVHGDNNATYLCGEVDEESRLLVERTREALNRAIKAVKPGRQINVIGRVIESYAKRFGYGVVRDFTGHGINSSFHSGLIIPHYDSPHATTVMEPGMTFTIEPMLTLGTHEYDMWDDGWTVVTKDRKRTAQFEHTLVVTETGAEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISK2</accession>
    <name>A0A0F4ISK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001140">
        <property type="protein sequence ID" value="KJY24985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24985">
        <property type="protein sequence ID" value="KJY24985"/>
        <property type="gene ID" value="VR44_33795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12956" checksum="12476E621AF95280" modified="2015-06-24" version="1" fragment="single">MIAPPMTTPPATPAPPGRRPRPTSVRRLFVVLAGLLILAVLGYLGLRLHHRLNTIDMPQGDTAPQGGYTLTVYFTPSEAYYHGPQRSIRRQVCPGQNLPDAFPADYLERVGMEGFGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITP2</accession>
    <name>A0A0F4ITP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001304">
        <property type="protein sequence ID" value="KJY24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951953.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24046">
        <property type="protein sequence ID" value="KJY24046"/>
        <property type="gene ID" value="VR44_36465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4593"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="570" mass="62240" checksum="DCFBDD8984CCF0EB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITT2</accession>
    <name>A0A0F4ITT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001294">
        <property type="protein sequence ID" value="KJY24096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951931.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001294.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24096">
        <property type="protein sequence ID" value="KJY24096"/>
        <property type="gene ID" value="VR44_36345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4521"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="33090" checksum="271150C92DDD55FC" modified="2015-06-24" version="1">MSTTRPSAPRLGTGRRILRATALAATLPYLTLKVAWLAGSRAGIPEGSILLRGGSALTVANAITLAMDACVILLALALTRPWGRRVPGPLLTLPVFAATGLLTPIVLGYPAQLLVKALGMGADEAADAAREPFLDPWVFAVVYSGFIIQAIALAGLFVPYARERWGRRWQGALGRGRLSSPTGVVAGAAALAGAVAGAVQLYWAFGGSAGLPAERVAAYSAETGVVSGAHAICALAAAAGALMLARGGALPAKWPLALTWIGASAAASWGAWTLIAVLGVNLGEGEPSTTAFFLAYADQMITGLLAGAVLVRHLLTRGEAGPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW5</accession>
    <name>A0A0F4ITW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001072">
        <property type="protein sequence ID" value="KJY25450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951217.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25450">
        <property type="protein sequence ID" value="KJY25450"/>
        <property type="gene ID" value="VR44_32470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3298"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11308" checksum="B5E27A3826A6AB5C" modified="2015-06-24" version="1" fragment="single">MLIPHAEKPHAGATGEDDEGNEDPGSLAGRGRRRAEELHRLFGPSHGAPLPRPAALFATGGPQSAPARCRQTLAPLATALHVPVQDRFAVGAEADLARAVLAGPAPALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU05</accession>
    <name>A0A0F4IU05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_36155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001276">
        <property type="protein sequence ID" value="KJY24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951895.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001276.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24171">
        <property type="protein sequence ID" value="KJY24171"/>
        <property type="gene ID" value="VR44_36155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4473"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY24171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="41765" checksum="F8837E7125B24D60" modified="2015-06-24" version="1">MDLDHSPEVAAFRAEARAWLREHVPDAALPSLETEQGFAAHREWEAELHAGRWSAVSWPEEYGGRGADIERWLVFEEEYWAAGAPGRVSQNGISLLAPTLFDHATPGQRARVLPSMASGEVIWAQAWSEPESGSDLASLRSRAERTEGGWLLSGQKTWSSRAAFADRAFGIFRSDPDAAKPHHGLTYLMFDLRAPGVTVRPIGRLDGKPAFAELFLDRVFVPDEDVIGEPGQGWRIAMSTTGNERGLTLRSPGRFLATAARLAALWRERGDPADTALRDRVADAVVGARAYELFTWAGATRFAAGGEIGAESSLNKVFWSQYDIALHETALDLLGPDAELAQGPWAEPWVFSLAGPIYAGTNEIQRDIIAERLLGLPKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUU7</accession>
    <name>A0A0F4IUU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001024">
        <property type="protein sequence ID" value="KJY25787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951052.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25787">
        <property type="protein sequence ID" value="KJY25787"/>
        <property type="gene ID" value="VR44_31600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3028"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="41664" checksum="0A18065CA45F13D2" modified="2015-06-24" version="1">MNDSPGWAAPGSPSDGQAPEAAQQPPAGGSADSKWSAAQPPPGQWSSPAAGQTPPQQPQQAAGWGAYPSQPGQQQPAAPYAYGNPGGGWGGPPPAAKPGVIPLRPLGLGEILDGAVATLRGHWRSVLSVSLVVAALSEIALLAVQRLTMDSLTVPDTQPTTPAQAVRALGDAGILYGAQYYLEVLGLILVTALLAPTVSRAVLGQPSTLGGTLKAVRPLAPRLLGLTGLLLLGSLAAGLLPALPGILLGSAALTALGIPVGLVLLAWFYVTFALAPPALMLERGTPAAALRRSAKLVRGSWWRVFGISLLTWIIRTITSTVIVMPFAAIAMVLAPGGLSGFLDGSAALSWTVLVITGIGAIAGATVTTPMQTGVTTLLYIDQRIRREALDLELARAAGVEGYGSTTPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUV6</accession>
    <name>A0A0F4IUV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001099">
        <property type="protein sequence ID" value="KJY25268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951302.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001099.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3196"/>
    <dbReference type="EnsemblBacteria" id="KJY25268">
        <property type="protein sequence ID" value="KJY25268"/>
        <property type="gene ID" value="VR44_32955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3411"/>
    <dbReference type="eggNOG" id="ENOG502ZW25">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21431" checksum="231F64FFBAFBF722" modified="2015-06-24" version="1">MPRQVFLYDPPDRFVAGTVGLPGRRTFFLQASQGPRVTSVSLEKTQVAALAERMDELLDEVVRRTGGNAPVPAVASTEAADTAPLDVPVEEEFRVGTMALAWDGEQQRMIVEAQALVELDADSEEDLAEAEERLLQDEENGPPMLRVRLSGAQARAFAKRALDVVNAGRPPCPLCSLPLDPEGHVCPRQNGYRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV54</accession>
    <name>A0A0F4IV54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_32300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001064">
        <property type="protein sequence ID" value="KJY25504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951185.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25504">
        <property type="protein sequence ID" value="KJY25504"/>
        <property type="gene ID" value="VR44_32300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3260"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="34409" checksum="8950CA885736BDC8" modified="2015-06-24" version="1">MSGEGYREVLELLREFSPLVQALPPRAALVQVRGARRYFGADAARIAEVVRLRAVARLGTDVRIGVADTWAVAAMASARITGPGGVLAVPAEQVPGFLAPLPVGSLYGLGSRQAEALRGFGLHTVGALTQVPPGVLERILGKRAGRLVAERARGIDPRPVTPRGLPSSAAVRTGFARQELDGPHARAALLGLVVRLGAQLRGRRQAARSLCLTLQFAGGTRWERSRRLTEPSAHDEDLRTLAYRLMDAAGLQRARLTGMVLRAEDLTAAEAVTRQLSLDPVREARLTVEAAIDRANARFGPGTVRPATVPAGLAREPLPAAAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWN5</accession>
    <name>A0A0F4IWN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001122">
        <property type="protein sequence ID" value="KJY25091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951397.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25091">
        <property type="protein sequence ID" value="KJY25091"/>
        <property type="gene ID" value="VR44_33445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3568"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="116"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="437"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="632" mass="67663" checksum="699BC9E57BBDAE08" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXK2</accession>
    <name>A0A0F4IXK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000905">
        <property type="protein sequence ID" value="KJY26765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950625.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000905.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26765">
        <property type="protein sequence ID" value="KJY26765"/>
        <property type="gene ID" value="VR44_29250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2197"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="31430" checksum="8CF55245FF82F73C" modified="2015-06-24" version="1">MDLRALRCFVAVAEEGHFGRAAARLHLAQPPLSRRIRELEADLGCRLFERIPTGARLTAAGEVLLAEARDLLERAERARERVRGAESERVLVLGTVTGAGLDVGAAALAALRRERPGLRVRLREAPITDPSAGLREGRVDLALTRLPFDTSGLTVRLLGEEPLVAVLPAEDPLAGRPRLHVAELAGRPRFRLPPGTDARWRAYWLGAPDDAPGPVVSSTEECLHAVLWEGTVGLLPAGAARRHARPGIAFVPVDGHAPSRIVTAHRATAPDPRAEALAQALTEAFAARPPAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY28</accession>
    <name>A0A0F4IY28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000886">
        <property type="protein sequence ID" value="KJY26920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26920">
        <property type="protein sequence ID" value="KJY26920"/>
        <property type="gene ID" value="VR44_28895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2119"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="376" mass="40201" checksum="12870534AFC22C2D" modified="2015-06-24" version="1">MPALQQPDWAGHEDLPAAVGELRHAPGLVGPGEVKAFGLLVAEAARGDVNILQAGDCAEDPADSTPEAVRAKVGMLDALAAAFSEITGRPTVRVGRMAGQYAKPRSRPTERHGGRELPVFRGHMVNGPEPDAAARVHEPRRLTDCYRAALSVHSALRTDTGWNRARTWTSHEALVMDYELPLVRGDGSGRAFLSSTHWPWIGERTRSARGAHVRLLAEVDNPVACKVGPTMTPAELLELCGLLDPERQPGRLTLIARQGAGAVRRGLPALVECVRRAGHPVVWMCDPMHGNTVTTPAGRKTRLVEEVVREVRGFRQAVECAGGTAGGLHLEATPDDVLECVADADGIAGLDGRPRPLCDPRLNLEQAATAVSAWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYW1</accession>
    <name>A0A0F4IYW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bromoperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000913">
        <property type="protein sequence ID" value="KJY26658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950675.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000913.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26658">
        <property type="protein sequence ID" value="KJY26658"/>
        <property type="gene ID" value="VR44_29520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2277"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29638" checksum="0952E9A9B072AA8F" modified="2015-06-24" version="1">MPYIKVAEGNSAPVELYYEDHGTGRPVVLIHGWPLNGASWEKQTAALLAAGNRVVTYDRRGFGRSDQPADGYDYDTFAADLDAVLTALDLRDAVLVGFSMGTGEVTRYLGTYGSERVAKAVMIGVVPPFLLKTDDNPAGVDGAVFKGIEEAIRADRFAFMTDFLADFYNVDVLGGERISEQAVQASWNVAVTASAKGTLDCVQAWLTDFRADLPRIDVPTLIIHGDADRTLPIDSTAVPLARLIDGAELKVVPGGPHGLLWTHADEVNSALLAFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ07</accession>
    <name>A0A0F4IZ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950417.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3082"/>
    <dbReference type="EnsemblBacteria" id="KJY27237">
        <property type="protein sequence ID" value="KJY27237"/>
        <property type="gene ID" value="VR44_28110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1865"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="33001" checksum="1F301D95F44C9BA1" modified="2015-06-24" version="1">MVTVDVPALVAQAREGRPRAVARLISLVEGASPHLREVMAALAPLTGGAYVVGLTGSPGVGKSTSTSALVTAYRKAGKRVGVLAVDPSSPFSGGALLGDRVRMSDHASDPGVYIRSMATRGHLGGLAWAAPQAIRVLDAAGCDVILVETVGVGQSEVEIASQADTSVVLLAPGMGDGIQAAKAGILEIGDVYVVNKADRDGADATARELNHMLGLGESRGPGDWRPPIVKTVAARAQGIDELVEQLEKHRAWMDERGVLAERRAARAAREVETIAITALRSRLADLHGDAHLGALAGRVAAGELDPYAAADALLDSLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J090</accession>
    <name>A0A0F4J090_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000849">
        <property type="protein sequence ID" value="KJY27314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950380.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000849.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27314">
        <property type="protein sequence ID" value="KJY27314"/>
        <property type="gene ID" value="VR44_27905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1830"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="19980" checksum="56D3F1F6648545F4" modified="2015-06-24" version="1">MAIADDLKKTLTDPTPLYFAAGTADLALQQAKKVPGLIEQLRAEAPARFEAVLDTDTKVVQEKAKVAQEAVTARVVEVFGAIDPKKLGETAQDLALRGVGVAAEYAVRAKETYDRVAEHGEQAVRAWRGEVADEIVDIAEVVEPEPAPAQEAPAEASTGEAGEEKPAAKKPAARRNGTRKPVSEAAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J095</accession>
    <name>A0A0F4J095_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-Ala-His dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1143"/>
    <dbReference type="EnsemblBacteria" id="KJY27148">
        <property type="protein sequence ID" value="KJY27148"/>
        <property type="gene ID" value="VR44_28390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="25300" checksum="9DA5C6E04EA42442" modified="2015-06-24" version="1" fragment="single">MSQNPIAETVASLMPRAKAELTELVAFQSVADWAQFPKSESEGAANWVADALRAEGFQDVALLDTPDGTQSVYGFLPGPEGAPTVLLYAHYDVQPPLDDAAWISPAFELTERDGRWYGRGAADCKGGFIMHLLALRALKANGGVPVSVKVIVEGSEEQGTGGLQQYAEAHPELLTADAIVIGDAGNFRLGLPTVTATLRGMSLVKIKLDTLGGNLHSGMFGGVAPDALAALIRLLDSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0H7</accession>
    <name>A0A0F4J0H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_28085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950413.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27233">
        <property type="protein sequence ID" value="KJY27233"/>
        <property type="gene ID" value="VR44_28085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1860"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12696" checksum="B64436F5F8BF96CF" modified="2015-06-24" version="1">MDIKTASALHRLRLISVPEALSFPALLIFGSLLSRISDIDYLMMPLGIVHGILFVIYAVFLLDVWNKAKWPLKKVALFFLLALLPFGGLYGDRLLKRDEADSVVAARAREAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0S5</accession>
    <name>A0A0F4J0S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000788">
        <property type="protein sequence ID" value="KJY27882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27882">
        <property type="protein sequence ID" value="KJY27882"/>
        <property type="gene ID" value="VR44_26545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1433"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12328" checksum="DAEC1FA251F12AD6" modified="2015-06-24" version="1" fragment="single">ARMVVAFAGGALAGWLVVRRERHPLVAHRGTVNHVQTLPRLRGRGIATALMNRVPQIARDEMGLERLGIAVRGGLGLEGFYRGLGWTEVGRWPGALRVAPGDDRDEILMSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1E4</accession>
    <name>A0A0F4J1E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000765">
        <property type="protein sequence ID" value="KJY28087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000765.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28087">
        <property type="protein sequence ID" value="KJY28087"/>
        <property type="gene ID" value="VR44_26105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1377"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34851" checksum="A388B45F06736A45" modified="2015-06-24" version="1">MASSQVPVIDLGPWRSGGPAERARIAGRVDEALQTAGFLLVTGHGVDPSLPARIREAARSFFRLPPEVKQPYAVSVGGRGWLGPGAEANSYAEGTASPPDLKESWSFAADEPTGVPSVDAEWFRPNTWPAEAPGLREPVTAYLRAMRALSDELLELLAVALTLPEDHFTRHTGHPTWGFNLNWYPGAETVGEPLPGQFRIGPHTDFGTVTVLDRERGAGGLQIHTDADGWQDAPWDPAALTVNIGDLLARWTGDRWRAGRHRVLPPPAHAPAEELVSLVYFYECDAHTRVESLPAPVGRVAHEPVDSHAYLRAKLDQITVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1U3</accession>
    <name>A0A0F4J1U3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949986.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000747.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28262">
        <property type="protein sequence ID" value="KJY28262"/>
        <property type="gene ID" value="VR44_25790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1262"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="30088" checksum="19BFB40FFFE381FB" modified="2015-06-24" version="1">MRLCTLTVDGREDVGIAVDGGIVRLGVLAELTGTTLGPTLLDVVVGDQLGSIRAALADPEARAKALLSAEPAFAPIYRHPPKLWGVGLNFRGHAADLDVEQPVGTPGSYLRPSSCVIGHGDEIVLPVQSERVTAEAELGVVIGRTCRDVAPEDAPSVIFGYTTILDMTAEDAIRVNPRYIPWSKAFDTFCSLGPWVVTPDEVGDLSSIRITTVVNGETIATNQVSAMMRDPYWQVAHFSGGMTLDAGSVLSTGTPGAGVIQDGDVVEAVVEGIGTLRNTVRRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J201</accession>
    <name>A0A0F4J201_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000742">
        <property type="protein sequence ID" value="KJY28310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28310">
        <property type="protein sequence ID" value="KJY28310"/>
        <property type="gene ID" value="VR44_25640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1227"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="17042" checksum="9C0271881E08DA74" modified="2015-06-24" version="1" fragment="single">ALAARYETGIALGRTGRAAEALDLFRSLVRDRTRAYGAADPETLRARHVLGVNLGRLDRWEEAVAEAREVGAARARALGAEHPDTLVSPDTLVSRRELAVGLGRLGRWDQALPIYRELSGIRERSLGDEHPDTVLAHADEAHCLERLGQVCYQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2G2</accession>
    <name>A0A0F4J2G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Multi-component regulatory system-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000767">
        <property type="protein sequence ID" value="KJY28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950061.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000767.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28054">
        <property type="protein sequence ID" value="KJY28054"/>
        <property type="gene ID" value="VR44_26175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1392"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="14132" checksum="F5E7975DBF9495D8" modified="2015-06-24" version="1">MRSTASDRLPIRGADRRPARVRPYSLTGGRTRFTQVLLVETFVATLDAGPAKTPDRMPEMRAIVEVCRRMRTIAEISALLKLPLGVVRVLVSDLADQGRIRVYGTGHGTGRPERALLERVLDGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2S8</accession>
    <name>A0A0F4J2S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_24905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949822.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28637">
        <property type="protein sequence ID" value="KJY28637"/>
        <property type="gene ID" value="VR44_24905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.981"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470069" evidence="5">
        <location>
            <begin position="45"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_85" evidence="6">
        <location>
            <begin position="133"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="703" mass="74926" checksum="37E981497F2EF3B0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2W1</accession>
    <name>A0A0F4J2W1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000767">
        <property type="protein sequence ID" value="KJY28053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000767.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28053">
        <property type="protein sequence ID" value="KJY28053"/>
        <property type="gene ID" value="VR44_26170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="16263" checksum="E908FA6D8D9C4CCD" modified="2015-06-24" version="1">MTAPSTYGLSSQARNLQWLLTDLVEEVPGVNSVAVVSSDGLLLLSSEAAPESGKAARPKGPRGASADLATIVSGLGSLTTGAAALMEFGSVKQTMVAMENGSVFVMSISDGSLLGVHATPDCDMGVVAYHMALFVGRAGHVLTPEVRSELRQSMENTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4U7</accession>
    <name>A0A0F4J4U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949768.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28768">
        <property type="protein sequence ID" value="KJY28768"/>
        <property type="gene ID" value="VR44_24600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.915"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24651" checksum="4163ECBF664DCAA7" modified="2015-06-24" version="1">MTEKAKGGGRTRRAVLFGGLGALAVGALAAQDEIRRAWWLLPGVSKPRKEGDVDSPGVSWTAASPANWRLADRPDDYRVDRIVVHVTQGDFASSVGAFQNPFHKASAHYIVRQDGHVEQMVRELDIAFHAGNRSMNERSVGIEHEGFIDRPQDFTDALYAASARLAADICRRYGIPVDRQHVLGHSEVPGADHTDPGPHWDWDRYLRMVREELARTAPPAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J593</accession>
    <name>A0A0F4J593_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000765">
        <property type="protein sequence ID" value="KJY28086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28086">
        <property type="protein sequence ID" value="KJY28086"/>
        <property type="gene ID" value="VR44_26095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1374"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470396" evidence="2">
        <location>
            <begin position="35"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="33828" checksum="13B71A9168BCE0A5" modified="2015-06-24" version="1">MRRGRTARVAAAPVVALAAVLALAGCAAGGTAGAERASGPERASGTEPTAGQSRVLARAEQILISRCMSARGFTYAVTEPVREEGAARSFPYGLDDVDWARAHGYGGRAERAAAEARAADPNQLYFHRLPARERALARTALMGASPTGLTATAPTGMTLTASKEGCIARAQSALYGDPAAWFRVKVVTMNLRPAQEERVRRDGRYAEAVRRWADCMKAAGRPYASPDDSRQAAAALAEELPPDRADAAETALAVTEATCATSTELGRVSRALDRAYGEEVRARHQDDIALGHRLQNAALPTAERVVSQYDRSTPSGGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5F8</accession>
    <name>A0A0F4J5F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000685">
        <property type="protein sequence ID" value="KJY28998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949657.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000685.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28998">
        <property type="protein sequence ID" value="KJY28998"/>
        <property type="gene ID" value="VR44_24010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="587"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="687" mass="73026" checksum="60890158B2E61FC2" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J707</accession>
    <name>A0A0F4J707_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949420.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29548">
        <property type="protein sequence ID" value="KJY29548"/>
        <property type="gene ID" value="VR44_22710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.474"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="29766" checksum="5486D1F324240B45" modified="2015-06-24" version="1" fragment="single">VRPLREVDVLVVPGFELRPGTDLDAPLARLAPEIAAIRARAAAGTALVSLCVGAFLLAEAGLLDGRRATTSWLHAGELARRHPEADVRPEHLVVTDRGVTTTAAFSAMYDFALDLVRRHNGAGVARTTARVALVDDARTSQTPYADPRLLPQPGREFSHRVMRRLDQDLAERYDLGALADAFRVSTRTLLRRFAEETGRSPLAHLQASRVRRARHLLETTDRTVAAVAAAVGYQDPGTFAALFARHTGHRPSAYRAAFRRPVRGPGPAADADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J774</accession>
    <name>A0A0F4J774_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_20970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30237">
        <property type="protein sequence ID" value="KJY30237"/>
        <property type="gene ID" value="VR44_20970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8924"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14127" checksum="1F292F6469A6A2AF" modified="2015-06-24" version="1">MAADGRPPHRDAQPGPHGVGDAMAEALRLLPATPAETSARPAPGGRLRTGPDSAAEDLVKLVLTLVELLRQLIERQALRRVEAGGLSEAQEEELGATLLALHDRMGELCAQHGYRLADLNLDLGPLGPLLPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J816</accession>
    <name>A0A0F4J816_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949221.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene145"/>
    <dbReference type="EnsemblBacteria" id="KJY29913">
        <property type="protein sequence ID" value="KJY29913"/>
        <property type="gene ID" value="VR44_21640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.206"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="24531" checksum="8F321C16C6DDCED5" modified="2015-06-24" version="1">MSIRVMLVDDQVLLRTGFRMVLAAQPDMEVVAEAGDGLEALEVLRATKVDVVLMDVRMPRLDGVEATRRICEPPEHPKVIILTTFDLDEYAFSGLKAGASGFMLKDVPPAELLAAIRSVHSGDAVVAPSTTRRLLDRFAPMLPTTAQEPENKEIERLTEREREVMLLVAQGLSNGEIAGRLVLSEATVKTHVGRILTKLGLRDRVQVVVLAYETGLVRAGGGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8H4</accession>
    <name>A0A0F4J8H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5513"/>
    <dbReference type="EnsemblBacteria" id="KJY30089">
        <property type="protein sequence ID" value="KJY30089"/>
        <property type="gene ID" value="VR44_21280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8981"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032026">
        <property type="entry name" value="Ad_Cy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16701">
        <property type="entry name" value="Ad_Cy_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="210"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="42331" checksum="FCCEB9D420FB8383" modified="2015-06-24" version="1">MDRRRPLTVGDSTSSASSSGSAGNPGTPIGRDRHTPFHEVDHAAQPTADPLAIRLEQLILGAERRYTPFQAARSAGVSMELASRFWRAMGFADIGQARALTEADVLALRRLAGLVEAGLLSEPMAVQVARSTGQTTARLAEWQIDSFLEGLTEPPEPGMTRTEVTYPLVELLLPELEEFLVYVWRRQLAAATGRVVQVADDEEMVDRRLAVGFADLVGFTRLTRRLEEEELGELVESFETTAADLVAAHGGRLIKTLGDEVLYCADDAATAAEIALRLIETMEADAQMPELRVGIAFGTVTTRMGDVFGTTVNLASRLTSIAPKDAVLVDGAMAEELSRTGAAPKSEKDAESEEGGGSYRFALQPMWQRPVRGLGVVEPWSLSRRTPKIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9B4</accession>
    <name>A0A0F4J9B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1089"/>
    <dbReference type="EnsemblBacteria" id="KJY30409">
        <property type="protein sequence ID" value="KJY30409"/>
        <property type="gene ID" value="VR44_20560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8823"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="39968" checksum="56482C7ABFF19AE6" modified="2015-06-24" version="1">MTEIEIGRGKRGRRAYAFDDIAIVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPQTAIRIGELGGLGVLNLEGLWTRYEDPQPLLDEIAELDEEAATRRLQEIYAAPIQADLIGQRIKEVRDSGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGAAEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLPKAIACGADAVMMGSPLARATDAPGKGHHWGMEAVHEDVPRGKKVNLGTVGTTEEILTGPSHTPDGSMNLFGALRRSMATTGYSELKEFQRVEVTVADSQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Q7</accession>
    <name>A0A0F4J9Q7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">VR44_22225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000622">
        <property type="protein sequence ID" value="KJY29716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5177"/>
    <dbReference type="EnsemblBacteria" id="KJY29716">
        <property type="protein sequence ID" value="KJY29716"/>
        <property type="gene ID" value="VR44_22225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.330"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="34236" checksum="1BD942597626E991" modified="2015-06-24" version="1">MLQRCLDLLAPALLAPALERPGAVVVDCTLGLGGHSEALLTRFPEVRLIGLDRDKEALRLSGERLAPFGDRATLVHAIYADLAEVLDRLGLPTVQGILFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQTTGISAAEVLNTYAPGELVRILRQYGEEKQAKRIVSAIVRERDKEPFSNSARLVELIRDALPQAAKRTGGNPAKRTFQALRIEVNGELSGLERAIPAAVDRIAVGGRIAVLSYHSLEDRLVKQVFTAGATSTAPPGLPVVPEKYQPKLKLLTRGAELPTEEEIAENRRAAPARFRGVERIREGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9S2</accession>
    <name>A0A0F4J9S2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000516">
        <property type="protein sequence ID" value="KJY31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948707.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000516.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31117">
        <property type="protein sequence ID" value="KJY31117"/>
        <property type="gene ID" value="VR44_18850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8383"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="27794" checksum="259337D79D106892" modified="2015-06-24" version="1">MSQELKAELLDVGLEAVRRAGELLRDGRPADLAVAATKSSPIDVVTEMDLAAEKLITGILAERRPGDGLLGEEGADVVGTSGVRWVVDPLDGTVNYLYGLPAWGVSIAAEYRGETVVGVVAAPMRGETYHAVLGGGAWSGSARLSCRAAAPLDQALVATGFGYLKSRREHQAEVARRIIPVVRDVRRGGSAALDLCDVAAGRLDGYYERGLNPWDFAAGELIAREAGALTGGRPGEPLSGELAVAASPAVFASLQPLLEEAGAWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA09</accession>
    <name>A0A0F4JA09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948931.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30578">
        <property type="protein sequence ID" value="KJY30578"/>
        <property type="gene ID" value="VR44_20070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8636"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="29940" checksum="D76476C5D5DA11D2" modified="2015-06-24" version="1">MHVFTTYDGTELAYHVQGDGEPLVCLPGGAMRASRYLGDLGGLAGRRRLIRLDLRGTGDSATPADEATYRVDHQVADVEALRLHLGLERMDLLGHSAAGNLAMLYAAAHPERVGRLVLVTPTPWAVGLAMTPEHWLGAARLRAGAEPYDTAIEALGRLLAGSAADGDRDLAAPLFHGRWDHAARALHAAGAAERNDRASMAFAADGAFDPPATRAALERFPREVLVLAGELDGGPTPELAAELARLFPAGVLDVQPAAAHFPWLDDAPRFASRVERFLATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA44</accession>
    <name>A0A0F4JA44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30674">
        <property type="protein sequence ID" value="KJY30674"/>
        <property type="gene ID" value="VR44_19800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8579"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8180" checksum="683239DB18FD3810" modified="2015-06-24" version="1" fragment="single">ALFSGEYGLDTIRGIERTAHRLLRPGGIVVIEHADTQGGQVPWIFADERGWADAADHPDLNNRPRFATARKAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC65</accession>
    <name>A0A0F4JC65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948428.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31800">
        <property type="protein sequence ID" value="KJY31800"/>
        <property type="gene ID" value="VR44_17395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8016"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="2">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="26660" checksum="A8BB96D8636252FD" modified="2015-06-24" version="1">MTGTSRPGAGAAGPAAPGGTQGAHWAPGAQILWRYRDHAPGRKGPVHIARPVTVVQDTDELLAVWMAPGTECVKPVLADGTPVHEEPLATRYTAPRTTVRAHWFGAGVLKLARPAEPWSVWLFWDHGWLFKNWYVNLEEPRTRWSGGVDSVDHFLDISVYPDRSWKWRDEDEFAQARRIGLIGAEQARQVEEAGRAALEVVKAWGPPFGDGWENWRPDPAWEVPVLPEGWDRTPAHMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCH6</accession>
    <name>A0A0F4JCH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5400"/>
    <dbReference type="EnsemblBacteria" id="KJY32052">
        <property type="protein sequence ID" value="KJY32052"/>
        <property type="gene ID" value="VR44_16760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7788"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7267" checksum="5D6BBF58D2529D5D" modified="2015-06-24" version="1" fragment="single">AVWWFVAAERAAQVQLIARAAGKPVLIDHRSAVATRERFGNDLAAWASYQPLWQTVARGGESVASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCI2</accession>
    <name>A0A0F4JCI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31514">
        <property type="protein sequence ID" value="KJY31514"/>
        <property type="gene ID" value="VR44_17960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8137"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13740" checksum="C8CA462433E47C84" modified="2015-06-24" version="1" fragment="single">MAEFDKKDDAVDATPGISEVDVVEAVTETAAVAAIEAPVERGEPILQVRNLVKHFPLTQGILFKKQIGAVRAVDGISFDLHQGETLGIVGESGCGKSTVAKLLMLLETATSGEVFYKGQDITKLSGKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCJ3</accession>
    <name>A0A0F4JCJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_16725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000443">
        <property type="protein sequence ID" value="KJY32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32072">
        <property type="protein sequence ID" value="KJY32072"/>
        <property type="gene ID" value="VR44_16725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7780"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="537" mass="57677" checksum="8DEA78A50B5BBF8C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDL7</accession>
    <name>A0A0F4JDL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948728.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31056">
        <property type="protein sequence ID" value="KJY31056"/>
        <property type="gene ID" value="VR44_18965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8396"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470843" evidence="3">
        <location>
            <begin position="33"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="36"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="28884" checksum="443A84666F9D574E" modified="2015-06-24" version="1">MRRPFARALAGALTLVAGAAVAPLAQAPTAAADSVVIGGQPVKVADSPWVVALASRDRFGGIRDGQFCGGVLVAPTTVVTAAHCLGRQVLGGPVDSVADFRVITGRTELRAPDGREIAVRAARVNPAYDPGTNAGDLAVLELAEAVPADHVLPMAGDGHPGYEAGTGAAVYGWGDTSGFGDYAYGLRAAQVTVLDDEVCRRAYPGNSDGQYRADSMVCAGDRSGGKDACQGDSGGPLVARGRLIGLVSWGRGCGRADSPGVYTRIAPLIDFVSGLQRGGRPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE73</accession>
    <name>A0A0F4JE73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948077.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32652">
        <property type="protein sequence ID" value="KJY32652"/>
        <property type="gene ID" value="VR44_15550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7510"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="10492" checksum="36C6FB9D6C2C128E" modified="2015-06-24" version="1">MAKWTPRHEAPEPLEGPVVATITGGTILWFAMFLVQLPFYGWFAERELLWWVWTCAAGGGLGLIGIWYVRGRDAALKRHAAQQARAAAGDQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEB6</accession>
    <name>A0A0F4JEB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32093">
        <property type="protein sequence ID" value="KJY32093"/>
        <property type="gene ID" value="VR44_16630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7759"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="295" mass="31217" checksum="E1230D8B676AF487" modified="2015-06-24" version="1">MIDVHRLRVLRAVADHGSFNRAAAALRLTPSAVSQHIAALERGLGQPVAERSTRGVTLTEAGRLLVETAETVAAELDRVRARIDRLAAGRPRLTVATFTSGGRHLLPGALSAFVRAHPEVELTVLEAEPEASLPMVRAGAADLALAYHFDGPLPSGAGLSWLPLLEDPLYAVLPAGHRLAERETVEPAELAADRWVLGCLKTEAFLRRYADRAGFELRTAASTTDYFFAQSLVGAGVGVTLVPHIALAPPEGSAVVPLAPPRPARHLGVAAPLRSPHPYATALARALRTSADGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF63</accession>
    <name>A0A0F4JF63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000380">
        <property type="protein sequence ID" value="KJY32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32967">
        <property type="protein sequence ID" value="KJY32967"/>
        <property type="gene ID" value="VR44_14870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7371"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="30775" checksum="678A0DA8F7765244" modified="2015-06-24" version="1">MVRVPVKVVAVLVVLPVRVVWDLVAACARGLGRHVLAPLGNGLGRGLVRLWRYVLKPLVLVVFYWPWVGMWRYLVAPVGSAVYRYLLRPLGMGAAWVVLVVGRYVLAPLGAGLGWVVRDLVAPPLAWVYRRVLTPLGHGVRWLVRGACLLVFVWPWVGLWRYVLAPVGRGVAWVVVHGVVPPLVFLVREVLAPAWHLAGRITRALGRGLRWLWRGCVARPLAWVHRRVATPVGHALREVWRRGHLAYLPRRGAGGAGRGAAGAVREPRGGTGEVTGAYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGD1</accession>
    <name>A0A0F4JGD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">VR44_14240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JZWV01000367">
        <property type="protein sequence ID" value="KJY33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947846.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000367.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3353"/>
    <dbReference type="EnsemblBacteria" id="KJY33265">
        <property type="protein sequence ID" value="KJY33265"/>
        <property type="gene ID" value="VR44_14240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7195"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="41529" checksum="2C746B039BED300C" modified="2015-06-24" version="1">MSRLRWLTAGESHGPALVATLEGLPAGVPVTTELVADHLARRRLGYGRGARMKFEQDEITFLGGVRHGLSQGSPVAIMVGNTEWPKWETVMSADPVDPSLLKDTGRNAPLTRPRPGHADLAGMQKYGFDEARPILERASARETAARVALGAVARSFLKEVAGIEIVSHVVELASAKAPYGVYPTPADVEKLDADPVRCLDADASKAMVAEIDQAHKDGDTLGGVVEVLAYGVPVGLGSHVHWDRRLDARLAAALMGIQAIKGVEVGDGFDLARVPGSQAHDEIVSTPEGIKRTSGRSGGTEGGLTTGELLRVRAAMKPIATVPRALATVDVATGEAAVAHHQRSDVCAVPAAGIVAEAMVALVLADAVLEKFGGDSVPETRRNVQSYLDNLQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGI6</accession>
    <name>A0A0F4JGI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">VR44_14150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000364">
        <property type="protein sequence ID" value="KJY33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3369"/>
    <dbReference type="EnsemblBacteria" id="KJY33330">
        <property type="protein sequence ID" value="KJY33330"/>
        <property type="gene ID" value="VR44_14150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7176"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="26935" checksum="4CC43293C820DDE8" modified="2015-06-24" version="1">MDARGPLCVGIDPHAALLDSWGLADDIAGLERFSRTVVEALADSVAVFKPQAAFFERFGSRGVAVLERTVADARAAGSLVVMDAKRGDIGSTMAAYASAFLDPSSPLFSDALTVSPYLGYGSLKPAVDLARESGAGLFVLALTSNPEGAEVQRAVREDGRSIGATMLAHLAAENAGAEPMGSFGAVVGATLGDLSSFDLDINGPLLAPGIGAQGATAADLPAVFGAAVGNVVPNVSRGVLKHGPDTAALRASAKAFADEIREAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK9</accession>
    <name>A0A0F4JGK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_15005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947975.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32903">
        <property type="protein sequence ID" value="KJY32903"/>
        <property type="gene ID" value="VR44_15005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7420"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23923" checksum="B890B796D5F3F814" modified="2015-06-24" version="1">MTIRILIADDEALLRMAFATVLEAQPDMTPVGGAADGAEAVRLSRELRPDVVLMDVRMPGTDGIEATRQVVEVSPDTRVLILTTFDLDAYAFAALGAGASGFLLKNTRPEELLTAIRNVAAGDAVLSPRITRRLLEDFRPHLADTAATVRDERLDRLSAREREVLVEVGRGLSNAEIAAALHLAEATVKSHLGRVLLKLELRDRIQAVVFAHEHRLVPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHG8</accession>
    <name>A0A0F4JHG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000368">
        <property type="protein sequence ID" value="KJY33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947853.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000368.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33254">
        <property type="protein sequence ID" value="KJY33254"/>
        <property type="gene ID" value="VR44_14275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7202"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046165">
        <property type="entry name" value="DUF6167"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19664">
        <property type="entry name" value="DUF6167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12608" checksum="CDB718F2DDFA237C" modified="2015-06-24" version="1">MFRRAFWFTAGAAAGVWATTKVNRQLKKLTPESLAAQAADKAVEAGHRLKDFALDVKAGMTQREDELNDALGLTHDPDRPDNVTALPGPRRLRAIGPDSTTHRSNLSYNRNEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHR2</accession>
    <name>A0A0F4JHR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SalK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947627.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33892">
        <property type="protein sequence ID" value="KJY33892"/>
        <property type="gene ID" value="VR44_13040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6727"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="31007" checksum="2A6797A457D7C576" modified="2015-06-24" version="1">MTIDPHAARHCWHAAINPLHATSYFSPELFEELGSLGVTHRVAVNLASRSAAMGAVGPGTVTATFYNYRHDLVTRHLPAVWDTTTPEQVLAARLRAADRTLRRLLGPETIASPELAEAADLAIRATEACTRHGRTLYAAHADLPVPEEPHLRLWHATTLLREHRGDGHLAALLITGLDPLEALVSHTATGRGMTAKWIKSIRGWEQSDLDAAADRLRARGVLDADGELTEEGRALRERLETETDRLDAAPYEHLGADGVARLHALGGAVVRQAIAAGAFPADLFGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI45</accession>
    <name>A0A0F4JI45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042815576.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6077"/>
    <dbReference type="EnsemblBacteria" id="KJY33469">
        <property type="protein sequence ID" value="KJY33469"/>
        <property type="gene ID" value="VR44_13905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7067"/>
    <dbReference type="eggNOG" id="ENOG5033PZR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="17012" checksum="070F12F4F1908BBD" modified="2015-06-24" version="1">MYGYDQNVSAGQQQYAAPQQMAGGYGEQPLYPEPSPPSLADAVRAFTTGSLSAEDFQQIFATSKVYCPRGETPGFLALHNTQQPVIPMFTTLKELRRYAGKESKYFVITGAEVIDLLPTGYGFVLDMEGDHRMVFDAKAVEQMVDFAMRRMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIT0</accession>
    <name>A0A0F4JIT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948003.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000387.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32871">
        <property type="protein sequence ID" value="KJY32871"/>
        <property type="gene ID" value="VR44_15130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7444"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="39220" checksum="3D2C2D7BEE22C635" modified="2015-06-24" version="1">MFVFVCAGCGAELTVPLSQVSLPVHARQQYGNGAQLPVLMESGTFAVDPDPWGGPWRLWDEIGPGEAEARGIHAPVRALSDGTPGASVIAPGDIRGTRLLPEKRGGACCGLDGADGPNMACQACGLPVATRVDDCSLWQMVRLGPDVVHRVPVDGVHAAPLSWAELAEKGEKTPPFEPIATWGGRLGPNHYWSWSPRWEAAAGHALAHLLIASEGQPVEVPDGLTADVFQRALDTLLPTGTLKRRAVLAGPGRSSPDAGVDILLVPVHPRTGRTWTPADPTTPACLVPLPLGVWLWLASPEPDLPVPASGRIAHDVLRDDPLPLLPHHPFRADRGTFHHTLVRLPAVRSPWLRTILENLTQSTSAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJA1</accession>
    <name>A0A0F4JJA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000301">
        <property type="protein sequence ID" value="KJY34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947479.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000301.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34275">
        <property type="protein sequence ID" value="KJY34275"/>
        <property type="gene ID" value="VR44_12230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6428"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23215" checksum="179F3DAE92777101" modified="2015-06-24" version="1">MASEEDRRVLDPERDAAALKALTHPLRIRLLGLLRQDGPATASELAVRTGESSASTSYHLRVLAKYAFVAEAEHRDGRERRWRAAHAATSWSGGAMAATPDSRAYVGLSRRVQIEHLETSLARHEADVAAGRLGEEWAGAAGISDQLPRLTPESLTELWDAFQSKLGELTARDATDPRAAQVVLLTAGLPLAPHTPAADAEPGADAEPGTSRTGAGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJF7</accession>
    <name>A0A0F4JJF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947410.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34462">
        <property type="protein sequence ID" value="KJY34462"/>
        <property type="gene ID" value="VR44_11880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6381"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="47847" checksum="A73D684CE7DDEDF5" modified="2015-06-24" version="1">MSTELSKARELLESGDPEGAMRTLRLAADGVASAEVAPLVARLAEGAGFTDLAEASADLAARPVEAESLYRFGYACVERGIPALAVPALREALRLSLASPPEPERTGFFRRMAKPRTRTRLAPRRVLLELVTALERLERHADALALLHEHDSLMEDWPDRYLTVYNALMAGRTDTARQVFDRLSEPEGVWVAPGRRVGRMLERAAALPPAGDQDLRGWHYALTGGLLLTLSPHGFDQGMTGRWAFLQDDLDSCRHGLERLRAVLAATGREPASVGLLPDRGSRALGLAASRLLGVPAHPYRPGTPDVLVVAYDLSACDPDTVHALTERAPGELLFEHATCWTETPGASADVCTLLVQSVTAPWEPGLRLSEDGRPERTEPDGRSAEELAEAILAADPAPPEGDGQTPDDPDAALAAFAARAAGLWADGPRDRIRSSGPVRSGRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK06</accession>
    <name>A0A0F4JK06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947384.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34515">
        <property type="protein sequence ID" value="KJY34515"/>
        <property type="gene ID" value="VR44_11745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6316"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_22" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14940" checksum="112EA93B3F740870" modified="2015-06-24" version="1">MTEPRDHPFVTAVKPLVDAMGGELMDPAQAEPDDVVLTWEGQELLAVRLPQLSDSLDHILAALERRHGMPLAQLDRKSKQDVVRILEARGAFSVRHGVETVAGALGVSRFTVYNYLNRDSGAQNKPAKAAKQNTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKQ9</accession>
    <name>A0A0F4JKQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBS domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34780">
        <property type="protein sequence ID" value="KJY34780"/>
        <property type="gene ID" value="VR44_11340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8747" checksum="F270D4C6DD93ABA5" modified="2015-06-24" version="1" fragment="single">MTLVQMQPHSANANPEHRTVDDAMEAARPQVCDDMTVEVALAVMASARVGHLLVCEEDGLCTGLVTQAGLATFRDSAAYTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKW3</accession>
    <name>A0A0F4JKW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947742.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33601">
        <property type="protein sequence ID" value="KJY33601"/>
        <property type="gene ID" value="VR44_13660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7008"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="13932" checksum="8B0C2F248EC6F915" modified="2015-06-24" version="1">MAITLVNPEGLPTVDAYRQVAVASGSRTVFIAGQVAWGSDGATVGVGDLAAQVERCYLNIATALAAVGGTLHDVAKLTVYVVDWTPDQMPQLMDGISRAAERLGVVPVPPATLIGVAALDVPEHLVEIEATAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL46</accession>
    <name>A0A0F4JL46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3027"/>
    <dbReference type="EnsemblBacteria" id="KJY33691">
        <property type="protein sequence ID" value="KJY33691"/>
        <property type="gene ID" value="VR44_13510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6953"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18508" checksum="63F7C219CB4912FA" modified="2015-06-24" version="1">MAGLEGVEQPRQRGSAMAVRLTAAVEDEQGLKALELYGNPAEAEVILPSMPESAGTARRLTQSVVVRFWGLSPQIAEHAVLLVSELVGNAVRHTGARSFGLRMLRRRGWIRVEVRDPSRGLPCLMPVHELDTTGRGLFLVDKLSDRWGADLLPRGKITWFEMRVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLT9</accession>
    <name>A0A0F4JLT9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947324.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34733">
        <property type="protein sequence ID" value="KJY34733"/>
        <property type="gene ID" value="VR44_11410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6179"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="12"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="369" mass="39964" checksum="2D41C51667A30D67" modified="2015-06-24" version="1">MPHIQPLPQYVALGDSYSAGQFIGGDTNLVREPVDGGLGGPDGDYSGRSKDSYPQQLARTVLSGYEFIDVTCGGATIDDRGLGLGGILTPQTVFGGPPYIPVDGSGVPQFTPTPRPAQIDALSKATTLVTIGIGGNQYNLGQIIAKCASLGASAIGSPGTDYYRHTEEGRADLARKEEDLRDGFAKMMPELRERAPHAKFFFVGYPTLFPTADPTLFPTAEGQGTCDGGLDENITIKKGDMPFIQQQFDLVDSVIREAARDHGHTYVDIAESTRAHHVCREGTEKWMFGLYARYTFDEELHGYKPARFPAGKDMPPFSPGWTAWMQGMLAHGDGIFRGNETLTTFHPNKRGADNQTRQVTTALRTAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLX8</accession>
    <name>A0A0F4JLX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947302.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34773">
        <property type="protein sequence ID" value="KJY34773"/>
        <property type="gene ID" value="VR44_11295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6153"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471174" evidence="1">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9542" checksum="BD951C31DA9A74A8" modified="2015-06-24" version="1">MKTFTRLVAVAAGTAAAALTIVPTAQAAPVAWPAAAGCRYYYTSYFTGPNGEKTGSGEYAEGDHDPEGRICRNGWWVSPYELEDPGAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMC6</accession>
    <name>A0A0F4JMC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947265.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34964">
        <property type="protein sequence ID" value="KJY34964"/>
        <property type="gene ID" value="VR44_11090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6102"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20952" checksum="C4271C02954315D0" modified="2015-06-24" version="1">MALDHAILVSLLEMPGSGYELARRFDRSIGYFWTATHQQIYRVLGRMAADGLLTVREVPQQGRPDKKEYSVAAPGRAALTRWLHEPIEPESMRHELAVKIRGAAFDDPAALIREVERHHRAHSDRLAHYLAGERRDFTGPAAPAPLDAGQELQHVVLRGGIAYERMTIAWLDDVLATLHRIGAATPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN70</accession>
    <name>A0A0F4JN70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34386">
        <property type="protein sequence ID" value="KJY34386"/>
        <property type="gene ID" value="VR44_11985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6482"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="11248" checksum="F085A047DC16E30B" modified="2015-06-24" version="1">MESEHVEPRRNRWTFLTNHARVLITIARDPGVRLRDIAAVCGLTERTVQAIVTDLQADGYLTRTRDGRRNRYVIAPGARFRHPAEADREIAGGAEPRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNK5</accession>
    <name>A0A0F4JNK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000229">
        <property type="protein sequence ID" value="KJY35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947132.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000229.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35348">
        <property type="protein sequence ID" value="KJY35348"/>
        <property type="gene ID" value="VR44_10380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5948"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470730" evidence="4">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="37475" checksum="60370ABD91AF9C5F" modified="2015-06-24" version="1">MTSRRTLLKGTLCGGAAALLPTAASASGGGGPVLRLPAPAGPYPVGMRTVHLTDPSRTDPWVGGVRELMLTVLYPARSVRGFSRAAQLTPAEAREFAGLAPQVHPGLPQPGRVDWGAVLTHGHVGAPPLPGRWPVLVYSPGGGDSRTLGTTLAEDLASRGRVVVLVDHPGDASQVELPTGLRTTALAGPPDPATFRTMVDTRIADLRLVLDRLGSLPLAGVVDSRRIGLYGHSAGGTAVVYAARDDRRVGAVANLEGYLDLYPVPSGFGRPLLLLRTDGFDGADRIESSWAGLPGHRALLREANHWAFTDYGSLVPRLQASGLVTAAARTALVGTGDPAVTLTEVRHRVGTFFARHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNW7</accession>
    <name>A0A0F4JNW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_09980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000215">
        <property type="protein sequence ID" value="KJY35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947059.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000215.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35529">
        <property type="protein sequence ID" value="KJY35529"/>
        <property type="gene ID" value="VR44_09980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5543"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="5"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="44165" checksum="C9123BAD536F735F" modified="2015-06-24" version="1">MSRRPLAAVLAANTISIAGSSLTLIGVPWFVLQTTGSAGRAGIVAFCATLPVVVAALVGGPVIDRLGRRRVSAVSDLVCAVSVGAIPLLHYAGLLEFWMLCALMALGGLVHTPGLTARSVLLPSLAAHAGTTVTRAASLYDAVSRGARMIGAAVAGLLIAALGAEAVLLMDAATFAVSALLVSAFLRGVPAAEPQPAAGKPSFTAYRAELAEGWRFMTRSRLLLGITVMVMMTNGLDQGWSSVLLPVHGREDLGGAAAIGLMISLFGGSALLGALLYGVWGERFPRRAVFAGAFLMSGAARYVVAAVTGTPLPLAVTMALAGLGAGVLNPILSTVVFETIPEELRSRVSGVTTAGCELVMPLGGLAAGLLVDVSGVRTALLAFGAVYFLTTLAPVVFPAWRAMDAKPASVVSRTERPLPGSAPAARPPRPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPY8</accession>
    <name>A0A0F4JPY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000196">
        <property type="protein sequence ID" value="KJY35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946891.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000196.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35823">
        <property type="protein sequence ID" value="KJY35823"/>
        <property type="gene ID" value="VR44_09070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5078"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470769" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="235"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="36986" checksum="96A9082EDE55DD17" modified="2015-06-24" version="1">MASHRRPKPPTRTRVSVLTALATAAVALSSQSAMAAPAPDKPNKDEVKTKVDALYEEAEQATEKFDGAKDRQDKLEKEIGYLQDQVARGQADLNDLRNTLGSLATAQYRGGGIDPSVELLLSGDPQKYLDNASTLQQLSGRQVEAIARIQAKQRELAQQRAEATAKLTDLDAVRKELAEKKATAQSKLAEAQALLNTLTAEQRGELKNDAAKDGAAAAKAAGGGTGAKPGAAKGSGRAGAALAAAITQEGDAYHMGDTGPNSWDCSGLTQWAYAQAGVSISRTTYTQVNDGTRIGRSELQPGDLVFFYSDLHHVGLYAGNGQVFHASNPTGGVRYEAMSNMPFQFGVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ72</accession>
    <name>A0A0F4JQ72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fbiA</name>
        <name evidence="4" type="ORF">VR44_10870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947224.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene461"/>
    <dbReference type="EnsemblBacteria" id="KJY35076">
        <property type="protein sequence ID" value="KJY35076"/>
        <property type="gene ID" value="VR44_10870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6054"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="33195" checksum="BA52D152C541A330" modified="2015-06-24" version="1">MRIVVLAGGIGGARFLRGLLSAVPDAEITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEDQGWGRTDESFTVKEELAAYGVGPSWFGLGDRDFATHIVRTQMIDAGYPLSAVTEALCDRWQPGVRLLPMSDDRVETHVAVNDPETGERRVIHFQEYWVKLRASLDAEAVVPVGAEQAKPAPGVLEAIAAADVILLPPSNPVVSIGTILAVPGIREAVAQAAAPVVGLSPIVGGSPVRGMADKVLAAVGVESTASAVALHYGPGLLDGWLVDTSDADAVETVTAAGIACRAVPLMMTDTDATAAMARAALELAEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQH9</accession>
    <name>A0A0F4JQH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946845.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36003">
        <property type="protein sequence ID" value="KJY36003"/>
        <property type="gene ID" value="VR44_08830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5012"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="36854" checksum="3E5373257C2932FB" modified="2015-06-24" version="1">MADITRRFGWRHLRSAPTTHIRHHRRGRLVHDGRGLSFWYRSLSAALSEVPVDDRELAMAFHARTADFQDVTVQATVTYRISDPAAAADRLDFSVDPDTGSWRGAPLEQISTLLTETAQQHTLDVLARTPLAVALVDGVASVRRSVAAGLAAEPRLPDTGIDVVAVRVVAIRPEAEVERALRTPAREQIQQEADRATYERRAVAVERERAIAENELASQIELARREEQLIEQRGVNSRREAEEAAAADGVRTEAEAARKVRLAQADAAAARETGSARAEAQASWLRVHDEARAGTLYALAATRLAENLPRVESITLTPDVLTGLLARLGRPDTGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQM0</accession>
    <name>A0A0F4JQM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000183">
        <property type="protein sequence ID" value="KJY36043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946838.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000183.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36043">
        <property type="protein sequence ID" value="KJY36043"/>
        <property type="gene ID" value="VR44_08790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5003"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="25194" checksum="D8FB16F0AA521ED5" modified="2015-06-24" version="1">MSDDPNAAREAPIKVFLLDDHEVVRRGLRDLLDAEPDITVVGEAGTAEQALARGPALRPDVAVLDVRLPDGDGITVCRELRSHMPGLACLMLTSFDDEDALLDAIMAGASGYVLKQIKGSDLVSAVRTVATGQSMLDPATTARLMRSLRDPEAPKEPEDARLAALTERERAVLELIGDGLTNRQIAKRLYLSEKTVKNHISRLLGKLGVERRVQAAVIAAQVHEQDHSGPGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS72</accession>
    <name>A0A0F4JS72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_06225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946358.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000116.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37217">
        <property type="protein sequence ID" value="KJY37217"/>
        <property type="gene ID" value="VR44_06225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2999"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004747">
        <property type="entry name" value="Cyan_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00896">
        <property type="entry name" value="CynX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="43996" checksum="C6EEA57E6BBAD13D" modified="2015-06-24" version="1">MHDEDLQTLSRPATPRGSAGRPATTPADIHADPKWLGPVLVVAIVLAALNLRPAITSLGALFEEARTGLHMSGTVAGLITSVPAFCFAVFGVTAPRLSRRFGPAAVVCAGMAAVAAGLLIRPFADSAAAFLAASALSLAGIALTNVLLPVIVKRWFPDRVGTMTGLYSMALAAGTSLAAAATVPLTSALGGNWRTGLLVWAVLAVAAVLPWLPVAAASRREKAAAPAAVQEDAGPSVVRSRTAWALACYFGLQATGAYVTMGWLPQIFRDAGVSASTAGVLLAVTMVMGVPLAFVIPGLAGRMRHQGPIAAVLGLFGLAGYLGLYLAPAAGAWAWALLLGVSNCAFPLVITMIGLRAKSPAGVVKLSAFAQSTGYLISIPGPLVIGTLYQHSGGWDLPLALMAGLLVPQIALGVLAGRDRTIEDECGMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS79</accession>
    <name>A0A0F4JS79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946578.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36689">
        <property type="protein sequence ID" value="KJY36689"/>
        <property type="gene ID" value="VR44_07435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3960"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="21079" checksum="CFFF4BDE5E1EDA29" modified="2015-06-24" version="1">MPRISLTPPRTLLMRLVAWYSRRTYGKVLDPGQAYGHHSRVLFAYLRLEQRAAKWNRLDAGLKHLAVMACAARINCSWCMDFGYWEGHELGLSPEKIERVPRWREDREVFTELELLVMEYAEAMTETEPAVTDEMAAELVARLGEAAFVELTAVVALENWRSRVNSAFGLTSQGFSEACRVPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSM8</accession>
    <name>A0A0F4JSM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyglutarate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000138">
        <property type="protein sequence ID" value="KJY36768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946545.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4590"/>
    <dbReference type="EnsemblBacteria" id="KJY36768">
        <property type="protein sequence ID" value="KJY36768"/>
        <property type="gene ID" value="VR44_07260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3793"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="43289" checksum="B7738933879EE14A" modified="2015-06-24" version="1">MQDAGVGGVSVGGGVDCDVLVIGGGIVGLSTAHALSSLAPGTRVTVLEKESGPARHQTGRNSGVIHSGIYYRPGSLKARFAVRGAAEMVKFCAEHGIAHEVTGKLIVATDRSELPRLHSLVQRGRENGIPVRELGPAQIAEYEPEISGLAAIHVGTTGIVDYGQVAAQLAESSGAEIVYGAEVDLISRRPSAVAVRTRSGQVVRARVLVNCAGLQCDRIARLAGDDPGMRIIPFRGEYHDLARPSLVRGLVYPVPDPAFPFLGVHLTRGIGGGVHVGPNAVPALAREGYRWGTVRPRDLGTELAWPGSWRMAARHWRYGAGEIHRSLSKAAFTEAVRRLLPAVTEADLTPATAGVRAQAVLRDGTLVDDFLIREAPRTVHVLNAPSPAATASLPIGREIAARALRTLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTE9</accession>
    <name>A0A0F4JTE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37430">
        <property type="protein sequence ID" value="KJY37430"/>
        <property type="gene ID" value="VR44_05705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="15828" checksum="3D085A144A5010C7" modified="2015-06-24" version="1" fragment="single">MTEKILDVLEQYYDTVPRRGGARAEDFGPLTLFVQEGNGWSYYARPSLGGADATPADVRKVLERQRELEVPEAFEWVAETSPSLRAAVEAAGLPVHAHPLMVLDAAAEPLAPHPEVRALGAEDPLLAAAVTVAGMAFREPGTGLGQAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTR6</accession>
    <name>A0A0F4JTR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">VR44_05020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946146.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene170"/>
    <dbReference type="EnsemblBacteria" id="KJY37757">
        <property type="protein sequence ID" value="KJY37757"/>
        <property type="gene ID" value="VR44_05020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1319"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="18508" checksum="E179043271309A77" modified="2015-06-24" version="1">MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTSYPTDYGFVENTLGEDGDPLDALVILDEPTFPGCLIKCRAIGMFNMTDEAGGDAKLLCVPASDPRVEHLRDIHHISEFDRLEIQHFFEVYKDLEPGKSVEGANWVGRAEAEAEIEASFKRLEAQGGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU66</accession>
    <name>A0A0F4JU66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946075.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37902">
        <property type="protein sequence ID" value="KJY37902"/>
        <property type="gene ID" value="VR44_04695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1020"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="27171" checksum="A1BF4D73E1F9C32B" modified="2015-06-24" version="1">MTTSTPTGAPAASPWFVRPPSQDPAARLFCLPFSGSGASAFSAWPAEIDGAEVCPVQFPGRENRLAHPHYGTYEELADSLADALAPLLDRPYALFAHCAGAIPAYETVLRLAERGLPAPRRLFVSGQPAPHDAGRDRMLGLTEPELRAELESFVRGRGIEPRPDMIDLGMFVLLRDHAAAGAYRRTEPARIDCPLVVLHWRDDTDVSAEDLQGWRHYAEQVEFRVVDGGHYGFMDAPAELLAALASWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU79</accession>
    <name>A0A0F4JU79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_05955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946309.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2619"/>
    <dbReference type="EnsemblBacteria" id="KJY37313">
        <property type="protein sequence ID" value="KJY37313"/>
        <property type="gene ID" value="VR44_05955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2405"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="21"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="458" mass="48729" checksum="0BF99E800F141DBF" modified="2015-06-24" version="1">MREQQTDLPPEPLSHSLKQRHLTMLGLGGVIGAGLFVGSGAGIGIAGPAIICSYLLAGALAMLVMRALGEMSAAMPASGSFSVYAEKALGRWAGFSAGWLYWFLLVVVLAVEATGAAKIAHGWLPSVDQWVWVLLFMVVFTLSNLAAVRNFGEFEFWFAALKVGAIVLFLVLGTLAVFGLLPDTDPVGLANLTGQGGFFPKGMGGVVAGMLAVVFAFGGLEVVTIAAAESDDPARSVSRAVRSAVWRILFFYVGSMLVIVALLPWDSLKPGESPYVAVLDSIGIPAAGQIMNIVVFVALLSALNANLYGSSRMVFSLAERGEAPKALLKVSGGGVPRRAVLASVVFGFASVVLNLLWPDTVFLYMLNAVGAVLLFVWALIAVSQLRLRPRLEREMPERLTLPMWAFPYLTWAALLGMAAVLVLMLFDDSARPQLLWSSGAAAVVLLVAAYREVRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUB9</accession>
    <name>A0A0F4JUB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000085">
        <property type="protein sequence ID" value="KJY37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000034_gene6783"/>
    <dbReference type="EnsemblBacteria" id="KJY37937">
        <property type="protein sequence ID" value="KJY37937"/>
        <property type="gene ID" value="VR44_04665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1014"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="44"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="39161" checksum="5EFE079304B35501" modified="2015-06-24" version="1" fragment="single">MTNAAEQTAEGADRVQRALRTLLEERDRLRQENEALRAGRGEPVAVVAMACRYPGGVSSPEELWEVVREGRDVVDAFPADRGWRDVYDPDPDTPGSAHVRHGGFLADPAGFDAEFFGISPREALATDPQQRLLLETSWEAFERAGIVPADVRGSEIGVFTGVSSTEYGWRFLEAGRSDLEGYLLYGSSLSVASGRVAYELGLTGPAVSLDTACSSSLVALHTAVQSLRAGECSLALAGGALVMSSPAAFVEFARQGALSPDGRCKAFADGADGTGWAEGVGVLLLERLSDARRNGHPVLALVRGSAVNQDGASNGLTAPNGRAQEKVIRRALANAGVAAGEVDLLEAHGTGTVLGDPIEAQALLATYGSGRDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVD2</accession>
    <name>A0A0F4JVD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945997.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene843"/>
    <dbReference type="EnsemblBacteria" id="KJY38115">
        <property type="protein sequence ID" value="KJY38115"/>
        <property type="gene ID" value="VR44_04245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.139"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="44"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19161" checksum="6FE5B74721C8C5F7" modified="2015-06-24" version="1">MAGHEFFEPADRKRKHHLADSVSSDLRAVEQTRLPCDPAFRHGVVVGFDGSTSSERALAYAIGMARRSGSGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLGLELACADYLSEVPWILVERGGDICHELEEVGREYSADAIVVGSTHGLVGRIFGSVAGRLAKRAQRPVVVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVU9</accession>
    <name>A0A0F4JVU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37096">
        <property type="protein sequence ID" value="KJY37096"/>
        <property type="gene ID" value="VR44_06525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3218"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="12231" checksum="A32F3C93A0208B29" modified="2015-06-24" version="1">MRRFGEKLSPRLVPILVNMSRRRIVRIERAIAGVDGYRKRAKVFSPYDALGAICATVPEYDRRWDPERKAWEVHDEHVQPLKDVFEAEGYEVRVTGSNLYRGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVZ8</accession>
    <name>A0A0F4JVZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946396.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37151">
        <property type="protein sequence ID" value="KJY37151"/>
        <property type="gene ID" value="VR44_06415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3195"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34485" checksum="C1C77074DA601BD1" modified="2015-06-24" version="1">MSTRPGPLITRTTAGAGHIAVFLAHWAGGHTVSEEELLRRIIKARADAHAEAVDEHQREARRAHKKATKLRRIAAEDGGLVPAAQSDLTRAEHDARRHEAALEALGDFEITDIDPGQVTHLRKRYAVLRCTALALPVAGVVAGSWLLDGVVLLVSTLGVVTACWLRGNTPFELSVRPVPAELLSATARLVLEPAEEDEAEPEPIEADDLGAWRQTLRRFVEHAVAQAHLEKKGGVLAVDLLQRLQASGLHLDKAPDAFPAVLRSADIPVKKISVDGTKALGVQYTDLTSALGRLPQLPVHLVPDLTQKTGQPQPLPQKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW58</accession>
    <name>A0A0F4JW58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ORF">VR44_04340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946012.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4238"/>
    <dbReference type="EnsemblBacteria" id="KJY38069">
        <property type="protein sequence ID" value="KJY38069"/>
        <property type="gene ID" value="VR44_04340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.436"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="638" mass="68339" checksum="46BC95EB2D801455" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWL6</accession>
    <name>A0A0F4JWL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplS</name>
        <name evidence="8" type="ORF">VR44_03975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030227407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene749"/>
    <dbReference type="EnsemblBacteria" id="KJY38239">
        <property type="protein sequence ID" value="KJY38239"/>
        <property type="gene ID" value="VR44_03975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8700"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="13187" checksum="E330E3EE5D837E76" modified="2015-06-24" version="1">MSHLLDGVNAASLRTDVPAFRPGDTINVHVRVIEGNRSRIQQFKGVVIRRQGSGVSETFTVRKVSFSVGVERTFPVHSPIFEKIELVTRGDVRRAKLYFLRELRGKAAKIKEKRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX35</accession>
    <name>A0A0F4JX35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000067">
        <property type="protein sequence ID" value="KJY38414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945901.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5778"/>
    <dbReference type="EnsemblBacteria" id="KJY38414">
        <property type="protein sequence ID" value="KJY38414"/>
        <property type="gene ID" value="VR44_03705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8279"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="290"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="489" mass="53360" checksum="21CD46C942F50C12" modified="2015-06-24" version="1">MNDLVRQHTALGETDLEWLHLLVSEWQLLSDLSFADLVLWVPTLDGTRYVSVAQMRPNTGPTSYQDDMVGHLVPRGRRPLLDAALDEGRIVREGDPEWREEVPVRVESIPVRREGRVLGVIARNTNLLTVRTPSRLELTYLQSASDLAQMIAAGSFPFPGQQVDMDASPRVGDGLMRLDADGVVTYASPNALSAYHRLGLAADLVGQHLGTTTAELAPSRGPVDEALVKLASGWAPRETEVEGNGGVIQLRAIPLKPKGTRIGSLVLCRDVTELRRRERELITKDATIREIHHRVKNNLQTVAALLRLQARRMDSESGREALNEAVRRVGSIAIVHETLSQNLDERVEFDEIADRVIAMVAEISPGKVQCRRIGRFGILDAEVATPLSMVLTEILQNALEHAFTQGEGGTVEVTAARSGSGRADGRLLITVLDDGSGLPEGFDPQKAGNLGLQIVRTLVEGELGGTFDMVRAEPRGTKVVLDVPVSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY14</accession>
    <name>A0A0F4JY14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="5" type="ORF">VR44_02940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945759.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4897"/>
    <dbReference type="EnsemblBacteria" id="KJY38729">
        <property type="protein sequence ID" value="KJY38729"/>
        <property type="gene ID" value="VR44_02940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7320"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8916" checksum="34502F674158E2C5" modified="2015-06-24" version="1">MAATQEEIVEGLAEIVNEIAGIPVEDVEIDKSFTDDLDVDSLSMVEVVVAAEERFDVKIPDEDVKNLKTVGDAAAYILKHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY79</accession>
    <name>A0A0F4JY79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotran_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39342">
        <property type="protein sequence ID" value="KJY39342"/>
        <property type="gene ID" value="VR44_01930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="38438" checksum="B3FE5A8D91553F14" modified="2015-06-24" version="1">MNPGPVMTHERVRSALAGPDMCHREPEFSRLLTRVRRKTTAVCGGGDEHTAVMLTGSGTCAVEAAISSAVPEAGGLLVIDNGHYGERLHHIARAHAVRTHRWELGWGTPVDLGALDRLLAADPGLTHVGVVHHETSTGMLNDVAAVTAIAHAHGREVVVDAVSSVGAEALSLRDDAPDWLAGSSNKCLEGAPGLSFVAARKAAFEALGSGPRRTYYLDLHRHYRAQEEAAAPAFTPGIPAFYAFDAALDLALAEGREARLARYTRLAQQLRGGLEGMGLEILLRPEHRAAALTAVRIPRGLTYAELHGGLRRDGFVIYSAQEQLAQDFFRLSTMGCMTAGEIGSFLSALERLITERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYQ5</accession>
    <name>A0A0F4JYQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945487.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39497">
        <property type="protein sequence ID" value="KJY39497"/>
        <property type="gene ID" value="VR44_01460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4725"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="29617" checksum="607E2530D77A708C" modified="2015-06-24" version="1">MTWTFSTDLAACLAAARPSVAAHPIVNTTLLSILDALERRGPHAYGDTDPVFGWWTAADGTVDGAVVHTPPFPLVLGALPPEAVRALGGALAADPLLARVTKFNARRADAGILAEAWGRPTRVAEELRLYRLGALRAPDPAPEGRARPATEADLPLLARWTAEFSRECDIPATPSEASLRDRISYGGFLIWEHGGRPVSLAAFFRPIGSASRIGPVYTPPAERRRGYAAGVTHAASGAAHAAGAGEVLLFTDLANPTSNSVYQRLGFTAVEDRVERVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K130</accession>
    <name>A0A0F4K130_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38931">
        <property type="protein sequence ID" value="KJY38931"/>
        <property type="gene ID" value="VR44_02665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6839"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="22709" checksum="8A56536E280688D6" modified="2015-06-24" version="1">MATRPLLAELSERIRHVHGLPVRFESAGGVEIARRVREGAEADLLVLADGALTALEEEGHLLAGSARPLWISQVVAAVPAGAPVPVLDSESGLRSALEAARSIAYSTGPSGTALVELIGRLGFADALAGRLVQAPPGVPAGSLLASGRADLAFQQHSELMDLPGVVIAGPLPGDTAISSTFGGAVLASASRPGPALEVLDFFGSGTGSESARARGMRAVQGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3C8</accession>
    <name>A0A0F4K3C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_00655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945340.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39686">
        <property type="protein sequence ID" value="KJY39686"/>
        <property type="gene ID" value="VR44_00655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011882">
        <property type="entry name" value="PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037834">
        <property type="entry name" value="PA_CoA_Oase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26657" checksum="77EF182B56A08002" modified="2015-06-24" version="1">MSADTATPPAATAAVLALADDALILSHRLGEWAGHAPVLEEEVALANIALDLLGQARVLLSMAGDEDELAFLREERAFRNLQLVEQPNGDFAHTIARQLYFSLYQHELYTELAAGDGPFAPLAAKAVKETAYHRDHAEQWTLRLGDGTEESRRRMRAALDALWKYTGEMFRPVDGLDVDPAALEARWLAALGRVLEQAGLSLPEGPRTGAWAAGAGREGLHTEPFGRLLAEMQHLHRSHPGASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8C9</accession>
    <name>A0A0F4I8C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001617">
        <property type="protein sequence ID" value="KJY18202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18202">
        <property type="protein sequence ID" value="KJY18202"/>
        <property type="gene ID" value="VR44_39650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6047"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="39"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY18202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="29515" checksum="F6E83B6ED8FA2B75" modified="2015-06-24" version="1" fragment="single">APTPRPGLLARLTARSRRGPDDAISGSGTPAAGAPATAATATALHIRRARAEVLHDVNLTVAPGETIALMGRNGAGKSTLLAALTGTLAPTTGQVTVGGRTPHRTPPPEMVRRVGLVPQDPRDLLYADTVAAECAAADADAGAAAGTCRALVSALLPDVPDGTHPRDLSEGQRLTLALALVLTGRPALLLLDEPTRGLDYAAKARLVETLRALAADGHAIVLATHDVELAAELAHRVVVLAGGEIVADGPTAEVVVSSPAFAPQVAKILAPGHWLTVSQVAAALQDPEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9S6</accession>
    <name>A0A0F4I9S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001586">
        <property type="protein sequence ID" value="KJY18815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952509.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001586.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18815">
        <property type="protein sequence ID" value="KJY18815"/>
        <property type="gene ID" value="VR44_39430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5975"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="11142" checksum="F5B4B1D5E7B401A6" modified="2015-06-24" version="1">MTALASFTFVRHIDGLRYRFERDGEHNGRPAYRRTDGKVWCVWSPADGWHCEITGDLVTARPLNSLADAPEPPATVWRSFKDDRSYLYDLQTVDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE30</accession>
    <name>A0A0F4IE30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001510">
        <property type="protein sequence ID" value="KJY20305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20305">
        <property type="protein sequence ID" value="KJY20305"/>
        <property type="gene ID" value="VR44_38740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5432"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469442" evidence="2">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10244" checksum="A16DD9879179BEE0" modified="2015-06-24" version="1">MQRAAMTVTLLTAVLAVAAPATTAAATDCRGTKGCMNKSMANGKASFYKGGMAFMDGNQAGVKGFQTGLNKGQNQFQKQMGPKRGGGGGGGMPGMPPGMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFI9</accession>
    <name>A0A0F4IFI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001514">
        <property type="protein sequence ID" value="KJY20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952390.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001514.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20238">
        <property type="protein sequence ID" value="KJY20238"/>
        <property type="gene ID" value="VR44_38795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5472"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9919" checksum="22607E757C3DC393" modified="2015-06-24" version="1">MELRFVGMDPNTGGEGSPTVWVEEESADLVLQGEEADELLAALVGATEWVAGHKAGIPAHERVIRIPARMVPILREACDAAERASAARRDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INR8</accession>
    <name>A0A0F4INR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001401">
        <property type="protein sequence ID" value="KJY23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23128">
        <property type="protein sequence ID" value="KJY23128"/>
        <property type="gene ID" value="VR44_37705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470116" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11623" checksum="66B02A5E75444129" modified="2015-06-24" version="1" fragment="single">MAAVIGGAAFAFTGTAQATAVGAVYTTSSSWNGGYTGQYVITNGTGRTQTDWTLSFDLPPGTRIDSLWNGTHTVDGQHVTVKPASWNRELAPGASVTVGFVASGSGAPGSPKGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP71</accession>
    <name>A0A0F4IP71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001349">
        <property type="protein sequence ID" value="KJY23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952073.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001349.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23840">
        <property type="protein sequence ID" value="KJY23840"/>
        <property type="gene ID" value="VR44_37100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4808"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="33820" checksum="8CE2E23AC229F8EB" modified="2015-06-24" version="1" fragment="single">DGLLAKVTEVVGKTDRGTEVKTAPTTLSAALGEAKADGKVKVDPSAMTVEPLMKGVTFSWAKGDGARFGAEGAKLPLGNLRLDVNAAIDTAKDAPASAGASVSGFVQLAPQVEFSYTGTKIGSAPSAAFLGMSGDWSSQWALKGRAAASTGAPKRIPFAKLHSAPVIQVGPVPVVVNLDLTAYIQVEADGQVTLDVQQDVKGDFRVGGSYATGKGWTPVSTSAVNSSPVKATVAASGRVKAALGAEASVGLYGAVGVGADFAPYLRGEADAKASASSDGKTSVSGAWALYGGFDLNGQLHLQLSLFGTPVLERRIPLGTLHREWPLVSGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPW7</accession>
    <name>A0A0F4IPW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001300">
        <property type="protein sequence ID" value="KJY24070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24070">
        <property type="protein sequence ID" value="KJY24070"/>
        <property type="gene ID" value="VR44_36400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4532"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7483" checksum="D4A182FA4438AA8C" modified="2015-06-24" version="1" fragment="single">LLGGLPLRRFARGDAPACLAWAATYGLIGILGGSLFSEPWKGVAAAVALTVLISSGPAVWRRFGDGRGTGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPY6</accession>
    <name>A0A0F4IPY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001301">
        <property type="protein sequence ID" value="KJY24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951942.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001301.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3613"/>
    <dbReference type="EnsemblBacteria" id="KJY24062">
        <property type="protein sequence ID" value="KJY24062"/>
        <property type="gene ID" value="VR44_36415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4535"/>
    <dbReference type="eggNOG" id="ENOG5033WVD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14740" checksum="56B3A1B473CC1080" modified="2015-06-24" version="1">MDALRVAAIASLAPLEELDADPFAVDTRSQHAMCARWAAAQGYVVTRQLLLYGLRADHCGLWRDVDAGQVDLFVAPNPRVLARALRSVEEFTAECARRGVRLETAGLDEPRYTPAMKAEVHRRLSMPTAGYDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ94</accession>
    <name>A0A0F4IQ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_36170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001277">
        <property type="protein sequence ID" value="KJY24167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24167">
        <property type="protein sequence ID" value="KJY24167"/>
        <property type="gene ID" value="VR44_36170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4476"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TetR_C_24" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7533" checksum="1AA982EF1E2745AC" modified="2015-06-24" version="1" fragment="single">AWLGTLERGVAAKVFRADLDIRLTYRFVRDTVWVAASWYRPGGQHSPEEIARQYLSMVLDGIAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQE9</accession>
    <name>A0A0F4IQE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001383">
        <property type="protein sequence ID" value="KJY23708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952147.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001383.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23708">
        <property type="protein sequence ID" value="KJY23708"/>
        <property type="gene ID" value="VR44_37520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4924"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045732">
        <property type="entry name" value="DUF6086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19564">
        <property type="entry name" value="DUF6086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13408" checksum="199D077E7980C290" modified="2015-06-24" version="1">MSQYYALGDRTLWNPSNGASRLFTRQVSLYEAELGLPSGIGPMRADECRIEPLVFSGFVDALLAWHGATRHAVVVSLSEGFVATVLVLADRAGVQVTWPPTASAETWAGALQQKSRELGRCMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQI3</accession>
    <name>A0A0F4IQI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001253">
        <property type="protein sequence ID" value="KJY24290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24290">
        <property type="protein sequence ID" value="KJY24290"/>
        <property type="gene ID" value="VR44_35780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="9729" checksum="752A72A566C913F7" modified="2015-06-24" version="1" fragment="single">MFIRPVNVTVTAATRPPGHPLLRGLLRRAAGAAEWSQDTGPGEDGATAEEALAEAFAEDEAEALAEAAGTAGMEGRAEAADEADAMARPTPWPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQQ2</accession>
    <name>A0A0F4IQQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001352">
        <property type="protein sequence ID" value="KJY23823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23823">
        <property type="protein sequence ID" value="KJY23823"/>
        <property type="gene ID" value="VR44_37140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469715" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="6644" checksum="6268D7573FB8B132" modified="2015-06-24" version="1" fragment="single">MNRKFDTTGSVRPQRRGFRLATLAAAAAIVTGGVVLPASAAMAAPAPSHVVTALPNGGGKGGDGGDGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQR2</accession>
    <name>A0A0F4IQR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001351">
        <property type="protein sequence ID" value="KJY23833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952081.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23833">
        <property type="protein sequence ID" value="KJY23833"/>
        <property type="gene ID" value="VR44_37120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4813"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32421" checksum="470E488C89EF8D3C" modified="2015-06-24" version="1">MLAVGIVTEVFGPRGEGMPAFDFALCSDRPGAVPTDLGVPLALTHGLDRLAEADLVIALPWTGFRTPPAPAVLEALAAAHDRGALVAAHCVGTFALAAAGLLDGRRATTHWRFTGLLADRHPAVTVEPDSLYVDEGRIATGAGAAAGFDMCLHLIRREHGAATANAVARDMVLPSHRDGGQAQYVAAPVPENCQDDRLAEVLAWARAHLHEPLPVEELARRALMSKRSFARRFTAATGTTPHAWLRGLRLSSAEELLETTDLPVEEIARRVGYGSAAVLREQFVRRRGVPPRSYRRSFTNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR05</accession>
    <name>A0A0F4IR05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001227">
        <property type="protein sequence ID" value="KJY24445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951744.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001227.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24445">
        <property type="protein sequence ID" value="KJY24445"/>
        <property type="gene ID" value="VR44_35350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="24315" checksum="E7BBD07AC46296BB" modified="2015-06-24" version="1">MDAFSTLIRVASQEQHTEAETSAFMSDLLGGRLGVEAYTRYTEQLWFVYRALEDAADALREDPVAGPFIRPELMRVAEIERDLAHLIGPGWREGVTALPATRAYADRVAQCARSWPGGYVAHHYTRYLGDLSGGQIIRDKAERTWGFERKGDGVRFYVFADIANPAAFKREYRELLDAIAADDLEKRRIVDECKRAFDFNGAVFRELGEEFPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISD4</accession>
    <name>A0A0F4ISD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="10" type="ORF">VR44_35510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001234">
        <property type="protein sequence ID" value="KJY24398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene683"/>
    <dbReference type="EnsemblBacteria" id="KJY24398">
        <property type="protein sequence ID" value="KJY24398"/>
        <property type="gene ID" value="VR44_35510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4216"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="106"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="613" mass="65774" checksum="995D139791ECEFC5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISP0</accession>
    <name>A0A0F4ISP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001135">
        <property type="protein sequence ID" value="KJY25007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951445.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25007">
        <property type="protein sequence ID" value="KJY25007"/>
        <property type="gene ID" value="VR44_33720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3657"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17095" checksum="70BC0C9392F04EBF" modified="2015-06-24" version="1">MTPITIISGDATSPQAKGPKIIAHVCNDLGGWGKGFVLAISKRWPEPEKDYRAWHRGRSGNDFGLGAVRLVRVRPDTWVANMIGQRGIRTGSAGVPIRYDALERCLTALSDHAVELGASVHMPRIGCGLAGGKWSRVEPLISQALSAKGVAVTVYDHDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT74</accession>
    <name>A0A0F4IT74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_34155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001158">
        <property type="protein sequence ID" value="KJY24854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951527.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001158.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24854">
        <property type="protein sequence ID" value="KJY24854"/>
        <property type="gene ID" value="VR44_34155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470388" description="Aminopeptidase N" evidence="12">
        <location>
            <begin position="24"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="50"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="257"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY24854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="494" mass="53914" checksum="A8AA37A31A0C17E0" modified="2015-06-24" version="1">MQLSSPRLRAALLAAASLSLVAAVLPPPKPLGIGDRLFPELGNPGYDVLSYDLSLTYKDNRTPLDAVTAIEARALAPLERINLDFTHGTVASAEVNGEPARFESAGEDLVLTPAHPLAANTPLRITVRHTSDPRGSADGGWVTTEDGLAMANQADAAHRVFPCNDHPADKAYFTFHVTAPEGYTVVANGLPGALPAARTAGTTEWTYRTLHPMATELAQVSIGRSAVLQRTGPHGLPLRDVVPAADRKRLEPWLRKTAGHIEWMEQHVGRYPFENYGVLIARARTGFELETQTLSLFENGLFAGEAEGYPEWYVEAIMVHELAHQWFGDSVTPRTWSDLWLNEGHATWYEALYADGLGKYSLERRMREAYQRSDQWRAAGGPPAAPKPAAPGQKIGLFRPVVYDGAALILYALREEIGTAAFDRVERRWVAEHKDGTAGTEDFVRLASQEAGRDLSAFLEPWLYGEKTPPMPGHPDWSAPAAKAAPKPAPGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT78</accession>
    <name>A0A0F4IT78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001109">
        <property type="protein sequence ID" value="KJY25202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951339.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001109.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene591"/>
    <dbReference type="EnsemblBacteria" id="KJY25202">
        <property type="protein sequence ID" value="KJY25202"/>
        <property type="gene ID" value="VR44_33155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3503"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="377" mass="38719" checksum="BF5925F803891029" modified="2015-06-24" version="1" fragment="single">RSFVEYGRAAATAALADAGLEWTDVEAVVGADTVRGGYPGYVAGATFARALGWQGARVTSVYAACASGAQAIGAARAQILAGLADVVLVVGADAAPKGFFAPAGGDRPDDPDWLRFRVLGATNPAYFALYARRRMALYGDTGEDFAQVKVKNSAAGALNPNARYRKAVTAGEVAASAVVADPLRLLDICATSDGGAALVLCSMEFARARGVADPVRIRAVSTVTPTYPRTVLDLPDIATDSVVAVRPAEGSFRASIARAAYEEAGLGPEDLSLAEVYDLSTALELEWYEDIGLCGEGEGAKLLREGATSLGGRVPVNVSGGLASFGEAVPAQAIAQVCELTWQLRGTAGARQVPGARVGITANQGLFGHGSAVVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU59</accession>
    <name>A0A0F4IU59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001059">
        <property type="protein sequence ID" value="KJY25542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25542">
        <property type="protein sequence ID" value="KJY25542"/>
        <property type="gene ID" value="VR44_32220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3165"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="29945" checksum="27A75BFCF6ECBC68" modified="2015-06-24" version="1" fragment="single">VLVVTSSPTLWQDTKDARAKLGPVLLYDPSHLCDTPARMHWNPADGCADRDTAAARAIALLAPVRPQARLDAAVADTAETLLRSWLQAAALDGLPFKQLARWAQGNGSQEPVRILRTHPQAAPGAAGELESALIAYPERREQAQYLTARALSCLTSVHIREACNPNRTDALTLASFAAEGGTLYVVGEPLEDPRTRPGAMPLLTALASHVVEHGRRMAARSSHGRLDPPMTLVLEDVAAVAPVPQLPDLLTDEKVPLLALCRSREQARARWPEWPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUE3</accession>
    <name>A0A0F4IUE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001251">
        <property type="protein sequence ID" value="KJY24306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951816.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001251.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24306">
        <property type="protein sequence ID" value="KJY24306"/>
        <property type="gene ID" value="VR44_35745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4303"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="15861" checksum="F7D22494D8E7527D" modified="2015-06-24" version="1">MDIARVLVIALVVAFVLVRRFGGRPVKDQDRLWVLPAVLAAVGAAQGGLVAPAHPVLSVVLLAAGIAAAFGTGHLIGRAMTLWREPDGTLWAKGNRTVLALFGLSLATRVALALLGAAVGVPVRNGALLVTLASWILAQGLALTARSRRIPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUI5</accession>
    <name>A0A0F4IUI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001116">
        <property type="protein sequence ID" value="KJY25138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25138">
        <property type="protein sequence ID" value="KJY25138"/>
        <property type="gene ID" value="VR44_33290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3534"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="29504" checksum="E01CF450A478D5F4" modified="2015-06-24" version="1" fragment="single">MIRFDQVSVTYEGAAHPSLRDADFTLPEGELTLLVGPSGVGKSTLLGAVSGLVPHFTGGTLRGRVTVAGRDTRTHRPRELADVVGTVGQDPRAHFVTDVVEDELAYGMESLGLPPAVMRRRVEETLDLLGLNELRDRPIATLSGGQQQRVAIGSVLTTHPKVLVLDEPTSALDPAAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADRVLLLPSPGEPPLLGTPADIMAVSPVHPPVVSLGRLAGWTPLPLSVRDARRHAPTLRARLSTQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUK0</accession>
    <name>A0A0F4IUK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001114">
        <property type="protein sequence ID" value="KJY25153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951358.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001114.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25153">
        <property type="protein sequence ID" value="KJY25153"/>
        <property type="gene ID" value="VR44_33250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3525"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="49"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="364" mass="39457" checksum="77740251D911E793" modified="2015-06-24" version="1">MSDHDGVLHVKGRVLAGPHEVHDELWVVGGRVTYERPAAAREVTTVTGWVLPGLVDAHCHVGLDAHGPVDAATAEQQALTDRDAGTLLIRDAGSPSDTRWIDDRADLPKIVRAGRHIARTRRYIRNYAHEIEPPQLVEYVGREARRGDGWVKLVGDWIDREAGDLTACWPRAEVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTEDTIPLFAERGVAIVPTLVNIATFPKLAAGGESKFPRWSAHMRRLHERRYDTVRAAWDAGIGVYVGTDAGGSLPHGLVAAEVQELVKAGIPPLDALSATAWAAREWLGRPGLTEGAPADLVVYGSDPREDVRVLAQPERVVVNGTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV55</accession>
    <name>A0A0F4IV55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001206">
        <property type="protein sequence ID" value="KJY24551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951689.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001206.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24551">
        <property type="protein sequence ID" value="KJY24551"/>
        <property type="gene ID" value="VR44_35050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4085"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20853" checksum="3C666101FADA6DB8" modified="2015-06-24" version="1">MQILSFPEAATPADLRVQVRRIQEQAWPSAHPSDAAVDTPGHDPALRPLSMLLVDEGTVLAALDILSKEIVHAGGRFTAGGLSTVVTDKHARGRGYGRRLVAAAHEQMQLRGLDLGLFTCDRPLQGFYEGAGWRVLPGAVLIGGTPQAPFRSDQPGFDKVTMADFFSPAARQAQASFHHCGIELYPGETDKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW37</accession>
    <name>A0A0F4IW37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001151">
        <property type="protein sequence ID" value="KJY24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24901">
        <property type="protein sequence ID" value="KJY24901"/>
        <property type="gene ID" value="VR44_34035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3734"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="28565" checksum="1FFC41D523BCF0C2" modified="2015-06-24" version="1">MTALEDLVRPDRYPRSSRYDPAWLLDLDMGPNPLWLLEDLAHDLDLRPGMRVLDLGSGKGATSVFLAREYGVDVVAADLWIAPEQAAQVFAKAGVGDQVEAVRAEAHALPFEEQSFDAIVSVDAFEYFGTADNFLPYLLRFLRPGGQLGMATPAMTREIRELGMIPPHIKEVVGWEAIAWHTAEWWRFQWDITELVKVTSARLQQDAWQDWLLWARAGAEHHPDGQSANQPVIDMLTTDRGEFLSFALVTAHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWZ7</accession>
    <name>A0A0F4IWZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26570">
        <property type="protein sequence ID" value="KJY26570"/>
        <property type="gene ID" value="VR44_29715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2320"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11943" checksum="E74204EF7642C59B" modified="2015-06-24" version="1" fragment="single">LARGVTPDRIRLALTTGLPSPVHHPAALVRKRLESKLPAAPPDPAPAPEPATPPARAECTECRASGPPAAFTDGRCRACRPEDPRPPVFTPTLTPAEVRAHAARIRERNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXS3</accession>
    <name>A0A0F4IXS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000961">
        <property type="protein sequence ID" value="KJY26268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950854.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000961.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26268">
        <property type="protein sequence ID" value="KJY26268"/>
        <property type="gene ID" value="VR44_30500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2515"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14454" checksum="E536F712D736FC0A" modified="2015-06-24" version="1">MSDAVEGGLGSGPDAGAGRFTALSERLTGFGTAELEATGLVEVYRAVAEEQLGPARYERLLSGPWQPDESADGDRADAARAVTILWYTGSWPGPAPFVVSPRAHAEALVWKAAGVVAPASVPAGYGSWAERPAETEGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYJ6</accession>
    <name>A0A0F4IYJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_31695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001029">
        <property type="protein sequence ID" value="KJY25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25751">
        <property type="protein sequence ID" value="KJY25751"/>
        <property type="gene ID" value="VR44_31695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3049"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="65"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="5">
        <location>
            <begin position="408"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="569" mass="59067" checksum="88F33FD4DFA7E409" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYV8</accession>
    <name>A0A0F4IYV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000861">
        <property type="protein sequence ID" value="KJY27187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950439.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000861.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27187">
        <property type="protein sequence ID" value="KJY27187"/>
        <property type="gene ID" value="VR44_28255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1894"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470569" evidence="1">
        <location>
            <begin position="42"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="75"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="26273" checksum="8383F140E412612E" modified="2015-06-24" version="1">MPASGKHRRPKQHKIARKLAFAGSGGAALALPLISATTAGAAVAQPAAAPAVRTVALPAAEPAAKPAAEKAAAPVIYSVVGGDTLAKIATEHSVSGGWQALYDANREVIGSNPSVIRPGLKLTLGGEAKAAAARATALAAKPAAAPAAVKTYANNLDGWIRQSLDIMARHGIPGTYNGIHRNVMRESSGNPLAINNWDSNAAAGIPSKGLLQVIDPTFRAYHVPGTAMDSYDPVANITAACNYAAARYGSIDNVNGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZB1</accession>
    <name>A0A0F4IZB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0167 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000900">
        <property type="protein sequence ID" value="KJY26823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950603.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000900.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26823">
        <property type="protein sequence ID" value="KJY26823"/>
        <property type="gene ID" value="VR44_29130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2167"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005363">
        <property type="entry name" value="UPF0167"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03691">
        <property type="entry name" value="UPF0167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19690" checksum="7C89D9C786567028" modified="2015-06-24" version="1">MSTDLPFFRYHPDPLATGSLRAATETCVCCKRDRGWIYTATFYTARDVDGRFCPWCIADGSAADRFAGEFTDPYGLDGVGEDVLHEVTRRTPGFHAWQDPHWLVHCQDAAAFVGEVGYPELAAHPEALDQLRTDLRLDGWHDETRLELFLTSLGQGATAMLFRCTACGTHLAYADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZH2</accession>
    <name>A0A0F4IZH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000988">
        <property type="protein sequence ID" value="KJY26066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950935.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000988.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26066">
        <property type="protein sequence ID" value="KJY26066"/>
        <property type="gene ID" value="VR44_30945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2695"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="25579" checksum="C8F6EE4A9D7CF341" modified="2015-06-24" version="1">MDHTFVPGPADSPAPAARLASLAAALADETRAVICLTLLEGRAWTAGELARTAGVAPSTVSGHLTRLIDAGICVTERQGRHSYVRIADAATARLVDELACYAVPGRDAAHTVPVVAAPDPLARARTCYDHFAGRLGMAVTDAMEERRLLRTDAVFELTGAGLDWCRQVGVDVAGAGRRPLASSCLDWTERRRHLGGLVGARLCARALREGWVVRPEGGGRGLLVTGAGEEAFGELLGLAPAAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0H9</accession>
    <name>A0A0F4J0H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950175.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27777">
        <property type="protein sequence ID" value="KJY27777"/>
        <property type="gene ID" value="VR44_26780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1514"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11007" checksum="B2AD003E7E7CD01E" modified="2015-06-24" version="1">MTRPGTAVRDAGLQPERTRLAWRRTTLACSVTAVLALRQALHGTGSPVEVGGVAVIALVWVAFLWVAHRRIRQLTAARPAALTPKAAAGAAACAVALAVFAMAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0M4</accession>
    <name>A0A0F4J0M4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_26680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950157.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000793.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27832">
        <property type="protein sequence ID" value="KJY27832"/>
        <property type="gene ID" value="VR44_26680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1495"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY27832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="556" mass="58454" checksum="987BCF13FA0C6F7B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0P3</accession>
    <name>A0A0F4J0P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000936">
        <property type="protein sequence ID" value="KJY26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950763.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000936.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2183"/>
    <dbReference type="EnsemblBacteria" id="KJY26471">
        <property type="protein sequence ID" value="KJY26471"/>
        <property type="gene ID" value="VR44_30005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2384"/>
    <dbReference type="eggNOG" id="ENOG50331SS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="26076" checksum="6157FD474533A1D8" modified="2015-06-24" version="1">MGRSRRTIPEELLLLALDPATGTTAQPQSLDLGLAGAQLVELALAGRIAPDGDRIAVVMPRPTGDPTLDSALELLRRRGSPVRAVHWIGGPRLGLRQIYLAHLERCGMVHAVAGQMCGVLPTTRYQATDTAISREIRARLDSAIRTGVPPDPRTAALAALAHAVGLGKHLYPGNEGRSSRSRLRDLIRHDPMGGLVAHAVMDVQNGVAAQPRRDRAPAPQPAARATAGGGVPLQPRRTGAMARAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J176</accession>
    <name>A0A0F4J176_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000769">
        <property type="protein sequence ID" value="KJY28035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28035">
        <property type="protein sequence ID" value="KJY28035"/>
        <property type="gene ID" value="VR44_26235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1407"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="19351" checksum="B26DDDED01003C89" modified="2015-06-24" version="1">MNPEHGADPEHGTHPGGAGRSAADRAAGPLLALSTVLIGLMAGLFFAFDVSVMPGLAAGDDRTYVTAMQHINAVIDGNGLFGGVFVLALLATAAAALVEYRKGRRGPAGWAGAAAVAYLAVLVITFAVNIPLNNELADAGDAAKMTGFAVVDKFKGTWVTTNILRTLLCTAALTALTRALLLHGRATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1N2</accession>
    <name>A0A0F4J1N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950177.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3172"/>
    <dbReference type="EnsemblBacteria" id="KJY27779">
        <property type="protein sequence ID" value="KJY27779"/>
        <property type="gene ID" value="VR44_26790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1516"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36766" checksum="FF060FC4F5FE6DE7" modified="2015-06-24" version="1">MTPADPRGLDLERLRGHLDAARPGLVAGPLTGRLIEGGRSNLTYAVTDGRARWVVRRPPLGHVLATAHDMRREHRVIAALHGTAVPVPEPLLLCEDAEVLGAPFYVMEHVDGVPYRTADQLAQLGPERTRRAVLGLVDTLVDLHAVDPEAVGLGDFGRPEGFLDRQLRRWGKQLAASRGRELAGIDELHAALGRALPASPAPAVVHGDFRLDNVLIGGPDDTIRAVLDWEMSTLGDPLTDLGLLVMYSSDLGLEDSPVSTTSRAPGHPAPAELVERYAARSGRDTGAIAWYTAFAWFKLAVILEGIHYRYTLGQTVGAGFDRIGELVPVFIAHGLTTLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J264</accession>
    <name>A0A0F4J264_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000782">
        <property type="protein sequence ID" value="KJY27939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27939">
        <property type="protein sequence ID" value="KJY27939"/>
        <property type="gene ID" value="VR44_26400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1464"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="25666" checksum="1A082EF59690B37E" modified="2015-06-24" version="1" fragment="single">STLSYLVPRLYDVTGGRVALDGVDVRDLDFDSLARSIGVVSQETYLFHASVADNLRFAKPDATDEEITEAARAAQIHDHIASLPDGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLILDEATSALDTRTEHAVQRAIDNLSRGRTTITIAHRLSTIRDADQIVVLDAGRIAERGTHEELLGAGGRYAALVRRDRDAAAHTPQRGRAADRGQGRGTDAETDTDADTDTAPTPVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2X5</accession>
    <name>A0A0F4J2X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000717">
        <property type="protein sequence ID" value="KJY28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28575">
        <property type="protein sequence ID" value="KJY28575"/>
        <property type="gene ID" value="VR44_25015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1093"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="512" mass="53918" checksum="FDC45B5F0D578A74" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J370</accession>
    <name>A0A0F4J370_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000741">
        <property type="protein sequence ID" value="KJY28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28314">
        <property type="protein sequence ID" value="KJY28314"/>
        <property type="gene ID" value="VR44_25610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046201">
        <property type="entry name" value="DUF6234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19747">
        <property type="entry name" value="DUF6234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16424" checksum="A4B9F63BE5A43CB5" modified="2015-06-24" version="1">MRAPGSQRQGEAMTQASPDTQRRRRWPWSNRTSTGADVTVAVLLFLIEAVVFLLGLFGHGMEGWAAQGDSERIAAAELAGRVWMSRFLVAVLVLAVVAMVSRARWTACAHLLAAAAVAALLVLAQHEHDRSHPGSPPRPGLEHALCFSGSSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J371</accession>
    <name>A0A0F4J371_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_24530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949755.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3014"/>
    <dbReference type="EnsemblBacteria" id="KJY28802">
        <property type="protein sequence ID" value="KJY28802"/>
        <property type="gene ID" value="VR44_24530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.901"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="193"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY28802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="49169" checksum="3484218C5E81D745" modified="2015-06-24" version="1">MAISVFDLFSIGIGPSSSHTVGPMRAARMFVSRLKKDGVLAQTTSVRAELFGSLGATGHGHGTPKAVLLGLEGHSPRTVDVETADDEVERIRRTGKLRLLGTEIGDVHEIDFDEPSQLILHRRRSLPYHANGMTLFAYDASGAPLLEKTYYSVGGGFVVDEDAVGQDRIKLDDTVLKYPFRSGDEMLRLANETGLSISSLMMENEKAWRTEEEIREGLLEIWRVMQSCVSRGMSREGILPGGLRVKRRAAATARQLRTEGDPLLHRSEWTTIYAMAVNEENAAGGRVVTAPTNGAAGVLPAVLHYYVNFVPGADEDGVVRFLLAAGAIGMLFKENASISGAEVGCQGEVGSACSMAAGALAEVLGGSPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNGMAAVKAVTAARMAMRGDGSHKVSLDKVIKTMKETGADMKVKYKETARGGLAVNVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4H0</accession>
    <name>A0A0F4J4H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_23445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29252">
        <property type="protein sequence ID" value="KJY29252"/>
        <property type="gene ID" value="VR44_23445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.631"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY29252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24922" checksum="D06D6499713F6450" modified="2015-06-24" version="1" fragment="single">MPLTPEDVRNKQFTTVRLREGYDEDEVDAFLDEVEAELTRLLRENEDLRAKLAAATRAAAQSQQQANMRKPEPQDQRGPGAPVPAAISGPPQQQQPQMGPPQLPGGQPQLPPGPGGHGPQGPGPMGGPMQQQSMGGQHPMAPQQQMGQQPMPQQMQQQSMGGQNQLGQPMGQQMQPMGQQMQPMGQQMQPMQQPQLPQQGPGGDSAARVLSLAQQTADQAIAEARSEANKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4J2</accession>
    <name>A0A0F4J4J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_26580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950136.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27856">
        <property type="protein sequence ID" value="KJY27856"/>
        <property type="gene ID" value="VR44_26580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1441"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="369"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="452" mass="47135" checksum="A3BD67A62577941A" modified="2015-06-24" version="1">MLRVAVVGSGPSGVYAAQTLVGQREVPGVRVDVLDRLPAPYGLVRYGVAPDHEKIKSLTGNLRSVLEDERIRFLGNVEVGGAPLTTARMLELYHAVVYCVGAARDRMLGIPGEELAGVHSATAFVSWYSGHPDAGSFDLGGVRSAVVVGAGNVAVDVTRILARGVPELEPTDMPQPALGALADSGVRTVAMVARRGPSQAKFTTKELRELGTLPGVETRADAAELALDPAYADPAAAAALPAVARRNLEVLRGWAEGPSAGGDGRRGIKLRFYLRPVEVLGGPDGRVRGMRFERTAPDGRGGVTGTGAYEDVEAQLVLRSVGYLGVPLPGLPFDPATGTVPHAAGRVVRAGRASVGEYVAGWIKRGPTGVIGTNRPCAKETVSSLLQDAGALARRDLPGDPLDALRAAGLRPVEWPGWLAIEAAEEALGRSLGRRSVKIPDWAGLHAAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J555</accession>
    <name>A0A0F4J555_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_26240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000769">
        <property type="protein sequence ID" value="KJY28036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950074.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000769.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28036">
        <property type="protein sequence ID" value="KJY28036"/>
        <property type="gene ID" value="VR44_26240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1408"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="9"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="342"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY28036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="463" mass="48649" checksum="56979A3B7D0FC604" modified="2015-06-24" version="1">MENSADGVYDVVILGGGSGGYSCALRATQLGLDVVLIEKGKLGGTCLHNGCIPTKALLHAGEVADELRRAESYGVRATFGGVDIAGVHEYKDGVIAGLYKGLQGTLKARKNLTLVEGEGRLVSPTEVEVGGVRYQGRQVVLATGSQPRSLPGLTIDGNRVISSDHALFLDRIPESAIILGGGVIGVEFASAWKSFGVDVTVVEGLPHLVPAEDVDISKSLERAFRKRKIKFELGSRFSGVEYTESGVRVSLENGKQIEAELLLVAVGRGPVSAGLGYEETGVAVERGHVVVDELLRTNLPTVSAVGDLIPTLQLAHVGFAEGILVAERLAGLPVTPIDYDGVARVTYCEPEIASVGLTEAKAKEVYGEDKVVVSKFNAGSTGKSKILKTAGDVKLVQVVDGPVVGLHMIGSRMSEQIGEAQLIFNWQALPSEVASLIHAHPTQTEALGEAHLALAGKPLHVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J584</accession>
    <name>A0A0F4J584_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_23005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949477.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29405">
        <property type="protein sequence ID" value="KJY29405"/>
        <property type="gene ID" value="VR44_23005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.538"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="136"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="41736" checksum="1A7DE1A7BE54DD11" modified="2015-06-24" version="1">MSFDTLEDAKAWLRRAGTDSERGEFVDPRDGSITVADYVARHWQAGVRGAPGTVKRVDERVRLHVLPHIGDVALRDVTASVLRGYIATLEGECAPRYARQILTTLSNVFETAIDDKRLVRNPMRAKSVRWPKVPEDQREAWPLETAQRVRDVVNQRYRIVVVVALGCGLRQGEVFGLSPVDIDFERGLIRVRRQVQLLYGRLYFTLPKGEKTRVVDMPPSVAAELRAHFLQHPAVEVELPWGGPEADREKRSFPLVLTTTYGNAIRANIFNDEVWKPALAKADVIPLREKGQRWKASRKDGFHVLRHTYASVILEAGESVVTLARWLGHSSPTITLDHYAHFMPEAGGKGRAAVDALLGVAPQYVPDDFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J635</accession>
    <name>A0A0F4J635_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase P60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949936.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28386">
        <property type="protein sequence ID" value="KJY28386"/>
        <property type="gene ID" value="VR44_25510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1200"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="192"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="34719" checksum="0B2118789AE58E80" modified="2015-06-24" version="1">MAGGIGIGLCLGFLVLVVVGTYSAAAGLAGGGGGRPLGLVKGAVPEKYQALVQKWGALCPALTPALLAAQLYSESGWDPKAVSPADARGIAQFIPGTWAGHGIDGDGDGDRDIWDPNDAIPSAASYDCELAKDVAGVPGDATSNMFAAYNAGAYAVIKYGGVPPYKETQGYVKDIRSLAKTFERPVGRVSPSQQAAGAVYFAQKQLGTPYLWGGDGTAADSGRFDCSGLTKAAYETVGVELPRVANDQYNAGSHPSRSELLPGDLVFFSDDLTNSREIRHVGLYVGGGYMINAPYTGAVIRFDKIDTPDYFGATRVTKEGAEALPERSPATPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6D9</accession>
    <name>A0A0F4J6D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949506.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000652.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29343">
        <property type="protein sequence ID" value="KJY29343"/>
        <property type="gene ID" value="VR44_23195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.579"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34379" checksum="61D7CD5F4254595F" modified="2015-06-24" version="1">MPGDEASAPAPAAATASLARAEQFIWLTARVLEQRRFAYHFLGGDADPVDTALGSYLGEDGGYGHALDPDLRGPLSQPLHTAHALRILDGLGRCSGRRIERLCRHLTRISTPEGALPLAVPAPRGHPAAPWHPAGDDPPAELVTTGPVVGVLHRNRIWDAWLFRATEFCWERVEGLRHPHPYEVQGAVAFLDGVPDRARAAAAADRLGRLVRERRLAVLDPARREEYPLSPGYAPGELLFPYDYARRPESAARSWFTDEEMGRSLDFLAAEQQPDGGWPVRRRAWAPGSTLERRPIATIEALLTLRAYGRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6E7</accession>
    <name>A0A0F4J6E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_23140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000651">
        <property type="protein sequence ID" value="KJY29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949497.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7545"/>
    <dbReference type="EnsemblBacteria" id="KJY29353">
        <property type="protein sequence ID" value="KJY29353"/>
        <property type="gene ID" value="VR44_23140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.567"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23015" checksum="4426645BEFB6A87F" modified="2015-06-24" version="1">MSGVPASAAGGTGRRPAPGAKLGTAAVSQAGLWNIANILTMVRLVLVPGFVLLLLADGGYDPVWRALAWAAFAIAMITDIFDGHLARTYNLVTDFGKIADPIADKAIMGSALVCLSWLGDLPWWVTGVILGRELGITLMRFWVIRYGVIPASRGGKLKTLAQGTAVGMYVLALTGPLATLRFWVMAVAVVLTVVTGLDYVRQAVVLRRAGLAAERAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7W1</accession>
    <name>A0A0F4J7W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000683">
        <property type="protein sequence ID" value="KJY29021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29021">
        <property type="protein sequence ID" value="KJY29021"/>
        <property type="gene ID" value="VR44_23930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.761"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="11367" checksum="1AAC1614BBDDB8C2" modified="2015-06-24" version="1" fragment="single">GSAVAGLRSCRIQHRAATPRPVWDPDLPSADRFRAQWQEVPDDGPVENGFKAQWELFLRHVVRDEPWRWDLLAGARGVQLAALGLRSCAEGRRLPVPEVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J810</accession>
    <name>A0A0F4J810_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948963.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30517">
        <property type="protein sequence ID" value="KJY30517"/>
        <property type="gene ID" value="VR44_20255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8758"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="29027" checksum="85051926BAEE6A0F" modified="2015-06-24" version="1">MSGTAGRGTALVLGGGGLVGIGWEAGMLYGLARAGADLTGADLVVGTSAGSVVGAQLTSGLLSPRELYERQLADPAGEIAAKLGAGLVARYALAMLRSRDAAEYGRRAGALALAADTPTEAERRAVLAARLVSHEWPERRLVVTAVDALTGEGAAFDREDGAGLVDAVAASCAVPGVWPPVTIGGRRYVDGGFRSAVNADLASGYRRVVILAPLPVGVGRLPSPVRQAERLRAEGARVLLITSSPEARKAFGRNLLDPARRAPAARAGLAQAAAHAAEAAAVWSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J886</accession>
    <name>A0A0F4J886_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949202.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29958">
        <property type="protein sequence ID" value="KJY29958"/>
        <property type="gene ID" value="VR44_21545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.187"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="688" mass="75168" checksum="9C167A97C5667FE0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8F4</accession>
    <name>A0A0F4J8F4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyA</name>
        <name evidence="8" type="ORF">VR44_19815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948882.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30677">
        <property type="protein sequence ID" value="KJY30677"/>
        <property type="gene ID" value="VR44_19815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8582"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="13"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="411" mass="42346" checksum="58E7CCCCFC46138C" modified="2015-06-24" version="1">MSVTTERATDVLRAQDPQMADILDGERQRQATTLQLSAAENFTSPAVLAALGSPLANKYAEGYPGARHHGGCEYADLAERVAQERATALFGVEHANVQPHSGSSAVLAAYAALLRPGDTVLAMGLAYGGHLTHGSPANFSGRWFEFVGYGVDAESGLVDYEQVQQLARAHRPKAIVCGSISYPRHLEYSAFREIADEVGAYLIADAAHPIGLVAGGAAPSPVPYADVICATTHKVLRGPRGGMVLCGAEFAERVDRAVFPFTQGGAQMHTIAAKAVAFGEAAGPAFTRYAHKVVANARALAAALRAHGLAVTTGGTDTHLITADPAPLGVDGPAARGRLAAAGIVLDTCALPYGDQRGIRLGTAAVTTQGMGEPEMALIAELFAGALGGADAAGTRAAVAELTGRFPPYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J909</accession>
    <name>A0A0F4J909_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948802.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000530.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30872">
        <property type="protein sequence ID" value="KJY30872"/>
        <property type="gene ID" value="VR44_19360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8480"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="349"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="439" mass="45527" checksum="342BDF9C93C9B69B" modified="2015-06-24" version="1">MAVWRALRLPLRFLGSWWPLRCWAYLGSGFVLGYGVLCALALLLGLGVLLAVAGIGLVLLAGALAGAVPLGELERRRLRWAEPEPVADPHTSLAGAGAGAWLRTRLRERATWREFGYALLFGPVFGAAGFGVLALLALSLLLVVAPVIVWALAPEPVMLIPGEAVAGPLEALGGTAVGLAGLVLAAYAAALVTGAQVKTARVLLGPREEDARVLELTRSRVRLVEAFEAERRRIERDLHDGAQQQLVALSMTLGLAELELRRAAGAEGAGGTTGADGADGATRADGAAVLVRRAREEAKLALAQLRDLVRGMHPQVLTDHGLAAAVAEVALRHPVPVTVDLQVPRLPEPVEVTAYFTVTEALANAAKHSGASRVAVAGRVEGGRLTLTVTDDGRGGADPGAGAGLAGLADRVAMLRGRLTVSSPVGGPTRLRVEVPCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9P0</accession>
    <name>A0A0F4J9P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948960.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6965"/>
    <dbReference type="EnsemblBacteria" id="KJY30514">
        <property type="protein sequence ID" value="KJY30514"/>
        <property type="gene ID" value="VR44_20235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8754"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15485" checksum="CA5E50097D02D939" modified="2015-06-24" version="1">MNVGELLAQTVPMARTLNLEFLETTSERAVVRLPDQPDFHNHVGGPHAGAMFTLAESASGAIVLAAFGDQLSRAVPLAVKAEIGYKKLAKGVVTATATLGRPASEVVAELDAGGRPEFPVTIAIQREDEAVTGEMTVVWTLRPHATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9T3</accession>
    <name>A0A0F4J9T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">VR44_19225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948776.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5439"/>
    <dbReference type="EnsemblBacteria" id="KJY30945">
        <property type="protein sequence ID" value="KJY30945"/>
        <property type="gene ID" value="VR44_19225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8451"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="42903" checksum="9A96210AAC7AA0C3" modified="2015-06-24" version="1">MSRTADAIRSADEHSAHNYHPLPVVVASAEGAWMTDVEGRRYLDMLAGYSALNFGHGNRRLIDAAKAQLERVTLTSRAFHHDRFAEFCTELAALCGKEMVLPMNTGAEAVETAVKTARKWGYEVKGVPDGQAKIVVAANNFHGRTTTIVSFSTDHEARDHYGPYTPGFEIVPYGDLTALDAAVTANTVAVLLEPIQGEAGVLVPPAGYLAGVRRLTRERNVLFMADEIQSGLGRTGKTFACEHEDVVPDVYVLGKALGGGVVPVSAVVADRDVLGVFRPGEHGSTFGGNPLACAVALEVIAMLRTGEYQQRAAELGDHLHRELNLLVGGGAVTAVRGRGLWAGVDIDPARGTGREISEKLMGLGVLVKDTHGSTIRIAPPLVISKEDLDWGLEQLRAVLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA27</accession>
    <name>A0A0F4JA27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000552">
        <property type="protein sequence ID" value="KJY30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948918.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000552.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30598">
        <property type="protein sequence ID" value="KJY30598"/>
        <property type="gene ID" value="VR44_20005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8623"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8071" checksum="AA4550A113F3677B" modified="2015-06-24" version="1">MCRSIKTLRPPAIPEKATEEEIRAAALQYVRKVSGFRAPAAHNREVFDAAVDAVAEATRLLLDGVQVRGRAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAH6</accession>
    <name>A0A0F4JAH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949195.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29951">
        <property type="protein sequence ID" value="KJY29951"/>
        <property type="gene ID" value="VR44_21510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.180"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="377" mass="38996" checksum="171AD24A63D785D2" modified="2015-06-24" version="1">MSAAGRPLTRAQKTVLGLAFVPMVGTGLAGGFGTYTNISNAYGSGTAVGAVAAGEGATAVLALVLLGLTMLGQSSPLVIRSGLWALPAAASAMSSMAAKSPGEIVIYALTPMGMTASAEGAAFLARRIVVHRDGRDGEAERRAAEVVQALAYHRARAAHHPDEKVRRKSELKAWTLARKVGTGDLTLGDRLLDVQRDRITAGADTALAAMFDTPTTPALTTGSTPSTPAIESGQTDTYRSTSDREESADPAPAASAPWAAEGPAPVMDATPDPVPADAAPAVDSTRPALVVAADRPRARRATGRVPQSARSSAPTRSRDELLAEARSLTESWSVKELTADRLRKTLRTSPANGRMLRDTLRGEREAAAAESAAADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBK1</accession>
    <name>A0A0F4JBK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylaspartate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31565">
        <property type="protein sequence ID" value="KJY31565"/>
        <property type="gene ID" value="VR44_17855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8114"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001495">
        <property type="entry name" value="Met_asp_mut_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="419" mass="44437" checksum="5B03B6F466297765" modified="2015-06-24" version="1">MAAAAARGVLVVQPRMGMPLPADMRAGLAAVRRARAATVGTITLDSYTRVGDHASARKALAEGSDLNGFPIVAHGAEETRRMIDALDDPRFAIQVRHGSPLPLGIVEALADAGLDATEGGPVSYCLPYSRTPLRDAVDAWARSCEVLAERVPGAHLESFGGCMLGQMCPPALLVAISVLEGIFFRRHGLTSVSLSYAQQTSFPQDREALAAMRRLASEYLDGVAWHVVLYTYMGVFPQTEAGAMELLRSSAVLAQVTGTERLIVKTAAEAFRIPTVADNVYALEEAAGAARGADPTTVPEADDSGLYEEARTLVESVLELDPDVGRALLKAFSRGLLDVPFCLHADNAGKSRAYVDQGGRLQWLSAGSMPVRAVAPAGAGRLTADGFLTMLSHVQRRFDGPVLERGRGRSGLTSSPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBS6</accession>
    <name>A0A0F4JBS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000464">
        <property type="protein sequence ID" value="KJY31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31817">
        <property type="protein sequence ID" value="KJY31817"/>
        <property type="gene ID" value="VR44_17370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8010"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="15741" checksum="BB2BE25F4459EB58" modified="2015-06-24" version="1">MARLVSGVAVVSARRADGSPCGLLVSSVSSYSVAPPSVMLALARGSRTFRAMDARVGTPFGVHLLGSADEALAKVFAGRAEDKFAGVAWDWDEGRPRIAGVPVYLKCRAAAVFPHGDHVVLLGEVADCTLTDGAPLVYYRRRLDWRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCF8</accession>
    <name>A0A0F4JCF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31905">
        <property type="protein sequence ID" value="KJY31905"/>
        <property type="gene ID" value="VR44_17210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7975"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="420" mass="46224" checksum="4A25C1F894C5814F" modified="2015-06-24" version="1">MPPDHPVYWRGADSTVWPRAGWRRTIAFVMIAGFVATAVPLFQIGLADSGNALTYGGRIAGVTVLFAAVVEVIAVGAAVNYWYWNKPPWRYSGAVVLAGVAISLLCSISLLLLQIGEHFNKYTAVGIILGTWSLAALIGLVKCRAWKGLRNPKKIAVGAVVSALLASANLAYSQIYLPYVTTPLIQSGAEFKEASLRKDQDRMYVTVHLYVRNAGRVPVYILDSIYWVHGGPANIEGVKTHRYELIYDGDFVSPVGRVLKPGEEIAQDEVVQVLNAEKKNFEVIRAQTEVYAIREDRVKMGPDYSRSGIGGRDLQMETEKGDPPSVKYRYRARISNSSEILNVTRDEQRITVWRTASPEWPGIVVDVSPPGERIAFDPLNPYANEKAIDRYGLAQVRGSTVEVPYAELLEKAGAVQKGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCL8</accession>
    <name>A0A0F4JCL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Indole acetimide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31554">
        <property type="protein sequence ID" value="KJY31554"/>
        <property type="gene ID" value="VR44_17830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8109"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="175" mass="18827" checksum="8493364384FE43E5" modified="2015-06-24" version="1" fragment="single">YEVCEVPDVPRLEETLDAYDRITCTEFAPAWPAVRTLLGEGGDRYIQLAMERTPPATAAELVGLMGTWLGIRRSWAEFLDAHPLVLGPSFTEPPVEPGLESRDRAGRDRVASGMRLCTATSFAGVPAVAVPTGLRDGLPAGVQIIGRAFREDLCLAAAQAVEDRLGVLTPVDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDB3</accession>
    <name>A0A0F4JDB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948772.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30941">
        <property type="protein sequence ID" value="KJY30941"/>
        <property type="gene ID" value="VR44_19205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8447"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="31262" checksum="52F194F542161723" modified="2015-06-24" version="1">MDWLKKLPVIGPLVSAVMRTRGWHSYELLDRVHWSRLAAAITFISFLALFPLITVAAAVGAALLTPEQLDRLQKSLAEQVPGISDQLDLPGLVANAATVGLVAGALLLLTGIGWIGSMRDCLRAVWEKDDEDQGNPFVRKGKDALVLLGLGGAALASAVASIAGSTAVGKSAEVLGIPREGAGGVLLRAAAFLVGVLAAFLLLLYLLSLLPGVEPPRARLLQAALIGAAGFELLKLLLSGYMRGVATKSMYGAFGVPIALLLWINFSAKLLLFCSAWTAVRDGEEQKEKEKETEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE51</accession>
    <name>A0A0F4JE51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000442">
        <property type="protein sequence ID" value="KJY32079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32079">
        <property type="protein sequence ID" value="KJY32079"/>
        <property type="gene ID" value="VR44_16705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7775"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="28583" checksum="3B8D8D265A1DDA36" modified="2015-06-24" version="1" fragment="single">MSHVSQAPVSTPDVEPAPPAPRSFDEVKGWFSAYDQVLFDWFLARQNDTADAKGDLLELGAFMGKSAIFLAAYLREGEEFTVVDLFDSPAPDGDNLEEVRESYPTLTRRGFEANYLAFHEELPTVIQAPTSVVPDRVRHGSCRFVHIDASHLHEHVVTDIASSKAVAAPGAVVVFDDYRSEHCPGVAAAVWEAVAVGGLRVIAVSASKLYATWDDPEPHQKALLGWLEGRTDLWHGVDTVCGRPLVRIGDHGVAAPPAPALLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE70</accession>
    <name>A0A0F4JE70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32099">
        <property type="protein sequence ID" value="KJY32099"/>
        <property type="gene ID" value="VR44_16665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7766"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="22424" checksum="3E27679530860C9A" modified="2015-06-24" version="1">MSTGSMRDAMRLLTAVERTPEQERTLGRVREKCRTVDGRLHGQGIDLEVSVAQALEELLDGTVGAAEGPGYHYALQALISSYFSDTHDLGDWRRQSWFWTVDEELSRVGVPARLALSRILTSGPPVRLPPAGDTTPWMGTFPTELAAEFVAAHEAVLARVDPQVRETVEVFLKAIRFEAEEWASADEDRRSGQDTMFFWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEW7</accession>
    <name>A0A0F4JEW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000420">
        <property type="protein sequence ID" value="KJY32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32308">
        <property type="protein sequence ID" value="KJY32308"/>
        <property type="gene ID" value="VR44_16190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7603"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24936" checksum="180444802B5E945C" modified="2015-06-24" version="1">MDLASDGAHIAALQREGGVPTGEGDTLKIYDVRARKEVRSVSGTQAGGAFSPDGRYFLTTDGTLLDLKTGTDRKESTFSGGVRHVAYSPDGRLVAAFRETGLVELWNGQVTQRITTMSSSVSRGGGRGGQDLGEFTFSPDGRLLAAVVDGDSVQLWDTDRHYALGDPLLLPGRGVEALAFDGDTLWAAAGTRARSVDLTPARLAERVCRRAGRDLTPLEWSTYLPGIPRRPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFU1</accession>
    <name>A0A0F4JFU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibrillarin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_14570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33060">
        <property type="protein sequence ID" value="KJY33060"/>
        <property type="gene ID" value="VR44_14570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7239"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470689" evidence="5">
        <location>
            <begin position="34"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="705" mass="72552" checksum="F7B02EDF2EAA005A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHT1</accession>
    <name>A0A0F4JHT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000328">
        <property type="protein sequence ID" value="KJY33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33912">
        <property type="protein sequence ID" value="KJY33912"/>
        <property type="gene ID" value="VR44_12975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6712"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="9895" checksum="3B05D8AAE5CD6A4E" modified="2015-06-24" version="1" fragment="single">AVAARFKARTRAEWTEVFEGTDACVAPVLSLGEAPHHPHLAARSTFTDFGGITQPAPAPRFSATPAAVVSGPARPGADTESVARDWDVPGLTGKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI99</accession>
    <name>A0A0F4JI99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32696">
        <property type="protein sequence ID" value="KJY32696"/>
        <property type="gene ID" value="VR44_15420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7485"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471067" evidence="1">
        <location>
            <begin position="42"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="57"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="42949" checksum="40A9A61B28503434" modified="2015-06-24" version="1">MSEQGVALMMPGGTARRTVLGAAVLAAGTGIGTLATGTASASEAGHGEGGYRDLPVPLVIGHRGSSGYRPEHTLGSYQLALDLGADVIEQDLVPTKDGHLVCRHENEIGGTTDVADHPEFTGRRTTKTVDGVSVTGWFTEDFTLAELRTLRAKERIPAIRQRNTLYDGRWAVPTFEEVLRWADREGKRRGKRVWLHVETKHPTYFRGLGLGLEEPLSALLRRYGRDGRNAAVFLQSFEPSSIQRLSRLVSAPRVVLLSAANTRPWDFETAKDPRTVADLVTPEGLKWIAGFAQGIGPTLDLIVPRTADGRLGTPTTLVRDAHARGLVLHPYTARNENTFLPAEYRKGTDPNAYGDAFGAFKRYFELGVDAIFTDNPDTGLLAAEAFRPGRGVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ48</accession>
    <name>A0A0F4JJ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000380">
        <property type="protein sequence ID" value="KJY32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947953.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000380.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2585"/>
    <dbReference type="EnsemblBacteria" id="KJY32966">
        <property type="protein sequence ID" value="KJY32966"/>
        <property type="gene ID" value="VR44_14865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7370"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="259"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="640" mass="71924" checksum="B7E12223381BE57A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJL8</accession>
    <name>A0A0F4JJL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000290">
        <property type="protein sequence ID" value="KJY34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34410">
        <property type="protein sequence ID" value="KJY34410"/>
        <property type="gene ID" value="VR44_11925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="9705" checksum="755EFEEE5A7DC23B" modified="2015-06-24" version="1" fragment="single">PGLLLAALPAMAAAYVSARAAGRKARPWTLLWAAGCVALLAVPALRDSAWPSTLAVLAAVLLAALALHGTRRWPGVLLAPIGFLGSAVAGVGWAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKX8</accession>
    <name>A0A0F4JKX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_11890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947412.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34464">
        <property type="protein sequence ID" value="KJY34464"/>
        <property type="gene ID" value="VR44_11890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6383"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="210"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="321"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="494"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="546" mass="57403" checksum="C014DE0731D5763D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL92</accession>
    <name>A0A0F4JL92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000251">
        <property type="protein sequence ID" value="KJY34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947273.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000251.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34945">
        <property type="protein sequence ID" value="KJY34945"/>
        <property type="gene ID" value="VR44_11130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="15339" checksum="EC02A1BCA622FAC8" modified="2015-06-24" version="1" fragment="single">MTDRRRTILEGAARVIARRGVRGLRVADLAEEAGVSTALVYYHFKDRPGILRQALAFIGDRADRYTEPSDAGAGQRPADPRELLERTLLREFQDLPEVRENSTAWGELRAHTVFDPELREELAAAGAAWVAEVAELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLU7</accession>
    <name>A0A0F4JLU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34743">
        <property type="protein sequence ID" value="KJY34743"/>
        <property type="gene ID" value="VR44_11470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9209" checksum="A7DB017025B0D6B4" modified="2015-06-24" version="1" fragment="single">MVKTPSVGQVMTGDVVKAHPDTSVKELIRLLTGHRISGLPVVDDDDKVVGVVSRTDLTRLPGDGAGGLVGRLTAGALMTTPAVTVHPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQA0</accession>
    <name>A0A0F4JQA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947211.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35111">
        <property type="protein sequence ID" value="KJY35111"/>
        <property type="gene ID" value="VR44_10800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6010"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="22087" checksum="C1AF91FF1571E61A" modified="2015-06-24" version="1">MAGSGWTEGAPPVRRRGPELERAILDAALEQLGSVGWNALTMEGVAAGARTGKAALYRRWPSKADLVADVLRRGLPALGETPDQGSIREDLYRLCVRMRDVMRSPAGMALRAVLHECDPAHGDLFREVIWKGLHEPAREVIGELLLRGIQRGDVRPDATSPLITDVIPAMLMYRAKVCGSEWPDREIAEMIDGLMVPMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQU4</accession>
    <name>A0A0F4JQU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="8" type="ORF">VR44_08505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946783.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene937"/>
    <dbReference type="EnsemblBacteria" id="KJY36123">
        <property type="protein sequence ID" value="KJY36123"/>
        <property type="gene ID" value="VR44_08505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4764"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22551" checksum="0B08BAF2451118C2" modified="2015-06-24" version="1">MSDEKSEKWQNPVAGFGVTFKAMFKKRLTEQYPEQEKTTAPRFHGRHQLNRHPDGLEKCIGCELCAWACPADAIYVEGADNTEEERYSPGERYGRVYQINYARCILCGLCIEACPTRALTMTNEFELADASRESLIYTKEQLLAGLTEGMVDTPHSIFPGMDEQDYYRGLVTGAAPGTERQVAVSKGEVPASNGAGNGAAAEGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR67</accession>
    <name>A0A0F4JR67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_07380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946569.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36680">
        <property type="protein sequence ID" value="KJY36680"/>
        <property type="gene ID" value="VR44_07380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3949"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="11">
        <location>
            <begin position="6"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="756" mass="83838" checksum="12598A3401480976" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS32</accession>
    <name>A0A0F4JS32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946463.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36975">
        <property type="protein sequence ID" value="KJY36975"/>
        <property type="gene ID" value="VR44_06765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3432"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="12181" checksum="76B6590D49A02DA5" modified="2015-06-24" version="1">MITDMEPVQPRTSWTFVTNHARILARISRDPEIRLRDLAESCRLTERAAQAIVTDLESAGYLTRMRHGRRNHYEVTPGTRFRHPAEGHREIGDLLHLLVDLGPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSC9</accession>
    <name>A0A0F4JSC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000146">
        <property type="protein sequence ID" value="KJY36663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36663">
        <property type="protein sequence ID" value="KJY36663"/>
        <property type="gene ID" value="VR44_07505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="36674" checksum="32BA056BF7D93AAE" modified="2015-06-24" version="1" fragment="single">MTSQDGATAQAWEALGGADGLAGRVSYRGPSGLEGPLPVRELARATVGVCGLAAAELAAVRAGGTALDAAPVVVDEGAVATAFVSERHLRVAGRAPVSFAPLSGFWRAADGWVRTHANYPHHEAALVRALGVPATPEAVRGALAERRAVEVQELVYGQGGLAVAVAPEYGEPQPLVEWTPGEGRGGRVLAAEPGRLPAAGVRVLDLTRVIAGPVATRTLGVLGADVLRIDAPGLPEADDAHADTGFGKRSALLDLGRSEDRAVLEGLLDEADVVVTGYRPGALEQFGLGGEELLERRPGLVVAELCAWGWRGPWAGRRGFDSLVQAGYGIAARCAGEDGTPGVLPAQALDHGTGYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSJ7</accession>
    <name>A0A0F4JSJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946390.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37145">
        <property type="protein sequence ID" value="KJY37145"/>
        <property type="gene ID" value="VR44_06385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3186"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="10046" checksum="0E45CD2B02704677" modified="2015-06-24" version="1">MTCTTTTKEKNMNERDWTELVGKEITVDDKPISSTDDESDLDRPTVYRGTVVSATNEPPALRIFLPRTRKEMTVYPNQWVIRVVGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSV5</accession>
    <name>A0A0F4JSV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946519.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36853">
        <property type="protein sequence ID" value="KJY36853"/>
        <property type="gene ID" value="VR44_07080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3761"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="414" mass="44912" checksum="0DC508CC8A3B1E99" modified="2015-06-24" version="1">MSKLTGWWKRRSSAGKVELYTRWSFHFFVLVEILSFGSMAFTVRDPADPRPLVPAVASFLVVCAHSVLVGFLSSRALDFVTGRRERPVRLAVATTAVTVTAVLLFLCLRRFAGLHEAAAPGLVLGVSCFGCGSLVLTLEKVRHMSYVPPAAAAWSAAAVTMLGLSPKEILGYFLGVLVTCAFLAFTCGFSGWLLRTVYELDHARELQARLAVAEERLRFGRDLHDVMGRNLAVIALKSELAVQLARRERPEAVDQMIEVQRIARESQMEVRDVVRGYREADLAVELEGARGVLSAAGMDCRVEFATAARQLPSEVQSALGWVVREATTNVLRHGDARSCLIRLTDREAAGTLTLLVENDGVPEAPAGPPGSGLAGLRERLAAVDGTLHAGPAGGGRFRLRAEIPLDGRRTEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT47</accession>
    <name>A0A0F4JT47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36989">
        <property type="protein sequence ID" value="KJY36989"/>
        <property type="gene ID" value="VR44_06760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3431"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="11198" checksum="E651885435C9EC3F" modified="2015-06-24" version="1">MVVEPGPQRVLARLRGEIDTEDSDGLRGRLTEALDSSRHGLDVDLSAVTFCDSSGLHILLDLNRRALTAGKTLVLTAASRPVARLLRLSGAEQVLTVRDRPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTF1</accession>
    <name>A0A0F4JTF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946754.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36256">
        <property type="protein sequence ID" value="KJY36256"/>
        <property type="gene ID" value="VR44_08340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4567"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13482" checksum="A029E7DD092059C1" modified="2015-06-24" version="1">MGSRPAEQASAADQGGAPKGVARQGVLSALPRSGRFAGDAQSRSLEDPTPERPGIRIYAAPVYRSHYDGARWSKRYADTPTAAYACRCGQTRTGTGQRSVAALVAEYNQHRETCPLLTSASEGREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU06</accession>
    <name>A0A0F4JU06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36436">
        <property type="protein sequence ID" value="KJY36436"/>
        <property type="gene ID" value="VR44_07950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4411"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22150" checksum="04C0E5E53AFBEB14" modified="2015-06-24" version="1" fragment="single">APDTLSALGRDEALLVLGGRRIVLGRRHSEILALLAQHPEGLTGEELAYALYEEESVAAVTLRAEMSRLRAVLGAGVLLSRPYRTAAPLEADFAAVTRHLAAGAVSAALTRYPGPLLPGSSAPGIVRLRRRIEDQARAAVIARADVGLLSDWVCSPWGADDPAVWRALASALPPRDRPAALARVRSLDAELGAGPGPGPGAGRATFPQPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUC6</accession>
    <name>A0A0F4JUC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946250.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2516"/>
    <dbReference type="EnsemblBacteria" id="KJY37419">
        <property type="protein sequence ID" value="KJY37419"/>
        <property type="gene ID" value="VR44_05640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1943"/>
    <dbReference type="eggNOG" id="ENOG5032U91">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="25045" checksum="050295EAF8B87C67" modified="2015-06-24" version="1">MSTAAVQPSPPARSGGAAAIGLILTIALSIVAPIVTYNTLVDDHGWSEASALLVSGVWPVLDSAIMVAWRRKLDEFAIVTLVFLAITAAVSLVGANSTRALLVKDSAVTGLFGLLCLATLLAPRPLMFYFGRKFGTDGTPAGVAYYNALWRFEGFRNAQRRMTLVWGVVYLIEAAVRIVLSYVLATSTMVSISPFMIYGTLGGLALWTVKFVKRTKAEGEKRAAAAAAAEQAGSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV82</accession>
    <name>A0A0F4JV82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000071">
        <property type="protein sequence ID" value="KJY38272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945925.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38272">
        <property type="protein sequence ID" value="KJY38272"/>
        <property type="gene ID" value="VR44_03850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8673"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21046" checksum="665C4FFDDEC4AE50" modified="2015-06-24" version="1">MSATIPAPVVSIAYHSGYGHTAVVAEAVRAGAAAAGATVHVVKVDEITDAEWELLDASDAIVFGSPTYMGTASGAFHVFAEATSKRWFGDAWQDKVAAGFTNSASKSGDKLNTLQYFQMLASQHGMSWVNLGLKPGWNSSTGSEFDLNRLGFSSGAAAQSNADEGPEAVHKADIATAEHLGRRVAEHTRVVVAGRAALAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVD6</accession>
    <name>A0A0F4JVD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946002.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38120">
        <property type="protein sequence ID" value="KJY38120"/>
        <property type="gene ID" value="VR44_04275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.145"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24178" checksum="D999D5A99C57848A" modified="2015-06-24" version="1">MRYAVLGTGIVGRTVAARLASLGHEVVIGTRDPRATLDRAEYAEWQEAHPSIGLAAFPEAARHGETLVNATGGRVSVEALTEADAAHLQGKVLIDIANPLDFSQGFPPRLDPVDDDSLGELIQRTFPQLRVVKTLNTMNCQIMVDPARVPGEHSVFLSGDDADAKKAVHDLLASFGWPDGSIIDLGGIETARGTEMLLPLWLRLMKALGHTDFNFHIQTARPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVF9</accession>
    <name>A0A0F4JVF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946163.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37738">
        <property type="protein sequence ID" value="KJY37738"/>
        <property type="gene ID" value="VR44_05185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1352"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="8650" checksum="9065A73E6F55A291" modified="2015-06-24" version="1">MAAEDYDSQLLESVAVRRRRLRDAVLFGAQRGRRVADERIGKAVAGLVIAAVLCAGCVGWSFVSHRVIGKVGTPGQVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXK5</accession>
    <name>A0A0F4JXK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chloride channel core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_03235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945820.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38559">
        <property type="protein sequence ID" value="KJY38559"/>
        <property type="gene ID" value="VR44_03235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7863"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="44734" checksum="77CB234D78B751D7" modified="2015-06-24" version="1">MTATQAGEAELLRGLLKTPAYRKTLVLCALIGIPVSLVCFWFLAGLDELQHLLWESLPDGLGWEAAPWWWPLPLLLVAGVVVGWVAARLPGAGGHVPADGLAMGGASTKVLPGVLVAATASLPLGAVLGPEAPLIALGGGLALLLRDLARGPGTPQASVLMGVAGAAAAISVIFGSPLIAAVLLIEVVGVGGPQLVAVMLPALLSSGLGALVFTGFGRWTGLKTGGLTVKIPGPVPRLDAADVGWGLLLAVAVAVVLRLAVGVGQGVAAFVTRQTVARTALCALGAGGCAAVYALATDRSPAEVASSGQALMGPMVGNPHAWGVGVLVAVLLCKTAAYALCLGSLRGGPIFPALFLGAAAGVLAAPLPGLGVVPAVAAGLAAAGASVLRLPVSSAVMALLLVDSLTMTPVVILATVAALVTAELLPLGRGRRRPEQPEGPQEPQAPAGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXN4</accession>
    <name>A0A0F4JXN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_02145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945612.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39137">
        <property type="protein sequence ID" value="KJY39137"/>
        <property type="gene ID" value="VR44_02145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5693"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="50"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="31517" checksum="F8A79207FEAA2267" modified="2015-06-24" version="1">MTPTPSLAAAGTAAATAGAPAKAPAKAPIGAVAARGPLPGVFRTGVLRARAELRVFFRNRTAVAMNMALPVVLMLLFGSIFTMKAGDHTVPMHDVVVAGVLASGVMSAAFGVLATGIALESGDGSLKRLRGTPFATGGYFLAKTVLVLVLALLQSVAVLALAVAVFDFQLPSTPGRWATLAWVFLLGSAATALLGIAVGSLITDRRTITAAVQFPFVLLQFVSGVYYSFSGLPDSVQRIGAVFPLKWMAQGMRAALLPDDMAALEPAHSWELGRVALVLGAWIVGGLVLCVAARVHRVRKDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXS4</accession>
    <name>A0A0F4JXS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945844.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38533">
        <property type="protein sequence ID" value="KJY38533"/>
        <property type="gene ID" value="VR44_03370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7891"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="364" mass="37185" checksum="C4E3A44A992C2334" modified="2015-06-24" version="1" fragment="single">IITEDPLLLDDLLRLCAAAGAEPHVHHAVPEQSGAGGGPGGGSEAAAPRGGVGWESAPLVLVGDDAARRVRGAPRRPGVFLVGRDLDDPFVWQRAVELGAEEVLRLPDAENRLVDRLADVVEGAGRPALTVGVIGGSGGAGASTLACALALRAARAGERTILIDGDPLGGGMDVLLGGEGAEGLRWPDFAASRGRVGAGALEESLPELHALRVLSWDRGDRVVVPPAAMRSVVAAARRRGGVVVVDLPRRVDEAVAEVLAQLDLVLLVVLGELRSVAAAGRVAAGVRMVARDVRVVVRGRCRQGLDAEAVAGLLGAPLAGEVPVEVGLPGRVAEGEPPGARGVLARFCDGFWQRALGPAQGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXW9</accession>
    <name>A0A0F4JXW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_02560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000040">
        <property type="protein sequence ID" value="KJY38970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38970">
        <property type="protein sequence ID" value="KJY38970"/>
        <property type="gene ID" value="VR44_02560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6816"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27610" checksum="28E981C73E886EA2" modified="2015-06-24" version="1">MVVEGLRKRYGDHTAVDGVSFSLAPGACLAIVGESGSGKTTTVRMLVGLERPDGGTVRLDGRDRSTRPRRRAERLARAREIQMVFQDPYLSLDPRVTVSGCLDEVLRLHTDLDAAGRGTRVTRLLDQVGLGTREAAALPRDLSGGQRQRVAIARALAVEPRVLVLDEAVAALDVSIQAQIIELLGQIRRASGIGYLFVTHDLAVVRHIADEILVLKSGQVVETGPASRVLESPEHPYTRLLLDSVPRRGRAPHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY28</accession>
    <name>A0A0F4JY28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945773.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38744">
        <property type="protein sequence ID" value="KJY38744"/>
        <property type="gene ID" value="VR44_02900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7312"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12300" checksum="3BFCC27E67683F99" modified="2015-06-24" version="1">MASTRRPGADHCGIAAAMTVIDGKWKVSILWELEQCPGRRFGELRRLVPGVSEKVLAAQLRELEADGIVHREVFDEVPPRVEYSLTPLGQELNGALESLGEWGAKHLLPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYJ4</accession>
    <name>A0A0F4JYJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945578.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39210">
        <property type="protein sequence ID" value="KJY39210"/>
        <property type="gene ID" value="VR44_01960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5798"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18285" checksum="29FFF36DD128C80E" modified="2015-06-24" version="1">MRGSGSASSRRTIAQRLDYLIGAIHPAGRGPFTYHEIAELIRERAGEGDPTVSHGTVQAIRTGKVTNPSVDSLRALADFFGVPTAYFLDDDVSEAVEDRIREIKESAAAAEAADELADVLQDNEVRAVAFRLGGLSARSIRGIKSIVEGFRQAEGLADVKPPPSRRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYU7</accession>
    <name>A0A0F4JYU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
            <shortName evidence="3">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acpP</name>
        <name evidence="6" type="ORF">VR44_01825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39320">
        <property type="protein sequence ID" value="KJY39320"/>
        <property type="gene ID" value="VR44_01825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5769"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 3 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3 4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9049" checksum="6F85E0ACF7627575" modified="2015-06-24" version="1">MTAVQSDTLQALKEIVDEVAGVPAEDITPESSFIDDLGMDSLTIVSLFVLIQRRFGTDVPNAVFDRLTTVGQAVAYLEHGEIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZT4</accession>
    <name>A0A0F4JZT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_01000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945419.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4745"/>
    <dbReference type="EnsemblBacteria" id="KJY39640">
        <property type="protein sequence ID" value="KJY39640"/>
        <property type="gene ID" value="VR44_01000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2913"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="14">
        <location>
            <begin position="222"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="488" mass="53402" checksum="E4B5F406511878B8" modified="2015-06-24" version="1">MDDPWADSGPSDRLPARPRRNGEGRGRGGDEDRDRGREGGSWDGGGGGFERVPPQDLDAEQSVLGGMLLSKDAIADVVEVLKGHDFYRPSHETIYQAILDLYAKGEPADPITVGAELTRRGEISKVGGASYLHTLVQSVPTAANAEYYAEIVHERAVLRRLVAAGTKITQMGYAADGDVDEIVNSAQAEIYAVTEQRTSEDYLPLGDIMEGALDEIEAIGSRSGQMSGVPTGFTDLDSLTNGLHPGQMIVIAARPAMGKSTLALDFARACSIKSNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGTMTDDDWTRLARRMPDVSAAPLYIDDSPNLSMMEIRAKCRRLKQRNDLSLVVIDYLQLMQSGGSRRPESRQQEVSDMSRNLKLLAKELEVPVIALSQLNRGPEQRTDKKPMVSDLRESGSIEQDADMVILLHREDAYEKESPRAGEADLIVAKHRNGPTATITVAFQGHYSRFVDMANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZX1</accession>
    <name>A0A0F4JZX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945522.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6515"/>
    <dbReference type="EnsemblBacteria" id="KJY39414">
        <property type="protein sequence ID" value="KJY39414"/>
        <property type="gene ID" value="VR44_01665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5734"/>
    <dbReference type="eggNOG" id="ENOG5032V8W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="20201" checksum="99E6AD99373E906F" modified="2015-06-24" version="1">MSIDPASIPNFGGQPEPQATGPAGPVVPDQDLVKQLLEQMELKYVIDDEGDLAAPWEDFRTYFMFRGEGEQQVFSVRTFYDRPHAIDDKPQLLESIDDWNRRTLWPKVYSHTHDDGSVRLIGEAQMLIGTGVSLEHFVSSTVSWVRASIEFDKWLVEQLGLEKEIDSAEGDSDTDGGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Y7</accession>
    <name>A0A0F4K0Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_00030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945251.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40055">
        <property type="protein sequence ID" value="KJY40055"/>
        <property type="gene ID" value="VR44_00030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="667" mass="68407" checksum="4EBE37CDB06BCDF0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Z5</accession>
    <name>A0A0F4K0Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_00035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945261.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene976"/>
    <dbReference type="EnsemblBacteria" id="KJY40065">
        <property type="protein sequence ID" value="KJY40065"/>
        <property type="gene ID" value="VR44_00035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471059" evidence="5">
        <location>
            <begin position="19"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="140"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY40065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="517" mass="53958" checksum="10C9DD970677BC5C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1D8</accession>
    <name>A0A0F4K1D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945661.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39036">
        <property type="protein sequence ID" value="KJY39036"/>
        <property type="gene ID" value="VR44_02450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6780"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24214" checksum="41711070779718A8" modified="2015-06-24" version="1">MRPPSRSRRADIMTTELGRRLAARRAAAGMSRHELGEHCGADAHYIASLEDDAALPTVGVLVRLAEALGTTVDALAGPRTPGDPVRPARPPHTDAQPVVLDEQECRRLLGVRGIGRVAVFTVDGPAVHPVNYLIADGEVAFRTRADTVLARAASTEAAFEAEKIDEVAARGWSVLAVGVLEAASHPEALERLAEAAHATPWAGGGRTHWMKLAPRRLTGRRVEFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1G8</accession>
    <name>A0A0F4K1G8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">VR44_00415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945293.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1051"/>
    <dbReference type="EnsemblBacteria" id="KJY39959">
        <property type="protein sequence ID" value="KJY39959"/>
        <property type="gene ID" value="VR44_00415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.81"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16855" checksum="3F8C219B99A4EFF5" modified="2015-06-24" version="1">MPRPAKGARLGGSAAHEKHLLANLAKALFEHGRITTTEAKARRLRPYAERLVTKAKKGDIHNRRLVLQTITDKSIVHTLFTEIAPRYENRPGGYTRITKIGNRRGDNAPMAVIELVEALTVAQQATGEAEAATKRAVKEAEAAAEAPAAEETKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3D2</accession>
    <name>A0A0F4K3D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945345.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39691">
        <property type="protein sequence ID" value="KJY39691"/>
        <property type="gene ID" value="VR44_00680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2842"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="30982" checksum="9B0EB363A8D46B71" modified="2015-06-24" version="1">MSEQSGQTAPEAPAASGDERPEARLERAVRAAEQALIEFEIAVETFRVEVENFSRLHHQKLGPMYSRLDELDALIAEAKAARSGDPEDLRRAREARSLVMPMPGVDELFHDWLDSDGISDDAAAMLTDRPVRPPQRVRPSEEVRRLYRELVRRAHPDLAQDEAERTRRDAFIARVNAAYGRGEEQLLRELAEEWDAGPVPEAAAPSESEELYARLEWLSQRKELLSMVAKELEDSAIGAMLRMAPDDPDRLLEEIAEQLLAQVSEREAELAALAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2U3</accession>
    <name>A0A0F4I2U3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AdoMet activation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_40540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001772">
        <property type="protein sequence ID" value="KJY16247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16247">
        <property type="protein sequence ID" value="KJY16247"/>
        <property type="gene ID" value="VR44_40540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="3">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY16247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="18084" checksum="019EDFC5F867728C" modified="2015-06-24" version="1" fragment="single">ELPPLKQRRVPQRAAVLDVREPEAAGRSEVAVDNPVPTPPFWGTRVVKGVQLKEYAGWLDEQALFKGQWGLKDAGSIATEGRPRLRGWLDRMHTDRLLEAAVVYGYFPCVSKGDDLIVLDEDGAERTRFTFPRQSRGRRLCLADFVRPEESGEVDVIGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3Z5</accession>
    <name>A0A0F4I3Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001778">
        <property type="protein sequence ID" value="KJY16188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16188">
        <property type="protein sequence ID" value="KJY16188"/>
        <property type="gene ID" value="VR44_40565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9508" checksum="DED60A5192AC8E1D" modified="2015-06-24" version="1" fragment="single">MRDELIAAAEWVCQYLGQLPEAPVSRPMPARLRDAPLDRTGGELRQILDFVREEIAPFPTGNGHPAFFAWINSPPAPAGLIAELLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFZ3</accession>
    <name>A0A0F4IFZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001478">
        <property type="protein sequence ID" value="KJY20940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952331.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001478.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20940">
        <property type="protein sequence ID" value="KJY20940"/>
        <property type="gene ID" value="VR44_38485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5347"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19059" checksum="340FEB6B9928B9B0" modified="2015-06-24" version="1">MTRTLYLFCSAAPPVFDVAHVIEDAQSRGWNVCVGLTPAAARWVSESLDGLAALTGNPVRWQYKLPGEPDVWPPADAVLFAPATFNTVNAWALGLTDRFTVGVAAEALGKGVPVVAMPCTNAALAAHPQFEQSLTVLRGAGAELLFGEGGFVPGPAGQDAPPHFPWQTALDAVDRAAAERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH07</accession>
    <name>A0A0F4IH07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001478">
        <property type="protein sequence ID" value="KJY20939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001478.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20939">
        <property type="protein sequence ID" value="KJY20939"/>
        <property type="gene ID" value="VR44_38490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5348"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="29811" checksum="538BB3849D432AC5" modified="2015-06-24" version="1">MTTNSNATKKTLVIGGNGKTGRRVAERLLVQGRPVRIGSRTGEPAFDWHRPETWGPALRDVDRVYVTYQPDLSFPGAADQVGAFAEAAVAAGARRLVLLSGRGEEAARTSEDRLKDSGADWTVVRASWFHQNFDEDFFLEPVRAGEIALPVADAVEPFVDAGDIADVAVAALTDDRHIGRTYELSGPRLLGFGEVAAELSKATGREIAYVPVSDGEFRAALREEGLPEEFAELFALILDGRNAHLVHGVEEVLGRPPRDFADYAREVAASGVWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKR5</accession>
    <name>A0A0F4IKR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001415">
        <property type="protein sequence ID" value="KJY22587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952215.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001415.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2358"/>
    <dbReference type="EnsemblBacteria" id="KJY22587">
        <property type="protein sequence ID" value="KJY22587"/>
        <property type="gene ID" value="VR44_37865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="113"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="349" mass="37820" checksum="5C2C799C5A701298" modified="2015-06-24" version="1" fragment="single">MTGSLPLRPRLRALRPEAFGADPSGARLERILRSPNFADGVFQNPVGARTRPAGSMLEFAKIYFHKEQRIRRNPGAPIPVYPTTLAELAKPPASGLRLTWMGHSSVLAEIDGRRVLFDPVWGERCSPFPFAGPRRLHPVPVPLASLGEVDVVVISHDHYDHLDLPTIKALAGTGTVFAVPLGVGAHLEHWGVAPGRLRELDWNETTEVAGLSLTATPARHFCGRGLRNQQFTLWASWVVAGEEHRIFHSGDTGYFPGFKEIGAEHGPFDATMIQIGAYSEYWPDIHMTPEEGMRAHLDLQGGAPSGTMLPIHWGTFNLAPHPWDEPGEGTVAAAGSAGAAVALPIPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INX4</accession>
    <name>A0A0F4INX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001378">
        <property type="protein sequence ID" value="KJY23730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952133.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001378.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23730">
        <property type="protein sequence ID" value="KJY23730"/>
        <property type="gene ID" value="VR44_37445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4908"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="26975" checksum="CD5A2537C17AD768" modified="2015-06-24" version="1" fragment="single">VAKLQTAFGKRSATPLQLTVGGKTVELKPEKAGLTLDSQTTVRNATGSDYNPVTVIGSLFGVERTAAAVMPVDEEKLKDSLQELAGTAGTASEGTITFDTGKAVAVPGKAGTSLDVDSSVDKVTKAFRELVANGKAAPVELPTATKEPTITQAELNRAMKEFAEPAMSGTVTVKAGTKSLAFGAKSLPKILSMQPVQGKLVEKYDLEALKATYGNAFDGVLITRGTGAKTPVTPQDVAGALGKGLVGKTPAERVVSIDTNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPH5</accession>
    <name>A0A0F4IPH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001332">
        <property type="protein sequence ID" value="KJY23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23915">
        <property type="protein sequence ID" value="KJY23915"/>
        <property type="gene ID" value="VR44_36875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4689"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15310" checksum="C3BA698D6AFC1496" modified="2015-06-24" version="1" fragment="single">LKLIPGFREGDERLLVCATNSIRSLDPAFLRPGRFDYLIPIGTPDAGARAAIWSRYTAGRADVDVAALVAATELFTPADIEHAARIAAQVSFERDLESVGARGAAAQPGATTADYLEAVAQCRPTVTPAMTGEFHADITAHARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPL1</accession>
    <name>A0A0F4IPL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001326">
        <property type="protein sequence ID" value="KJY23942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952021.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001326.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23942">
        <property type="protein sequence ID" value="KJY23942"/>
        <property type="gene ID" value="VR44_36810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4674"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469720" evidence="2">
        <location>
            <begin position="25"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="3">
        <location>
            <begin position="76"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="746" mass="81466" checksum="4AEA14B70D33D89A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPV5</accession>
    <name>A0A0F4IPV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001307">
        <property type="protein sequence ID" value="KJY24032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951962.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001307.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24032">
        <property type="protein sequence ID" value="KJY24032"/>
        <property type="gene ID" value="VR44_36515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4608"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046195">
        <property type="entry name" value="DUF6227"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19738">
        <property type="entry name" value="DUF6227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="29231" checksum="3983B0F0D47E67A7" modified="2015-06-24" version="1">MSDPYETTEAHLERLLGRALNSFDLPDALVERLGSALAHSSSLYTTHHSPSAGLWRETHRHTYLLSDGETVSLWELAYRTKDDRHSRHEVFASREELSLAGARLFGEAAAEPALSPPPGPGAAGEEGPGWGADGTEEDLALLSALFAAPDPRERHREYTVEDSADHARRVLRRAENADRPGQEVAALLRSAYAHQITQAFGGRQSLADGRDAGFSLYEHAFVLLDGTELSLWEVEHTATPDGRHMCEVYASEPAARGAMELRTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK5</accession>
    <name>A0A0F4IRK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">VR44_37660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001397">
        <property type="protein sequence ID" value="KJY23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952175.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001397.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene37"/>
    <dbReference type="EnsemblBacteria" id="KJY23306">
        <property type="protein sequence ID" value="KJY23306"/>
        <property type="gene ID" value="VR44_37660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5037"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="32805" checksum="01969DBD18108724" modified="2015-06-24" version="1">MRADRVFAYGVTAGLIGDRILGDPRRGHPVAAFGRAAAAVERALWRDDRARGVLHTLVCAGTAAAVGALGARAVRSRPAAARIALTAAATWAVVGGTTLGREARAIGGALAAGDTEVARERLPHLCGRDPQALDDQEMARAVVESVAENTSDAVVGALVWGAVAGVPGLLAFRAVNTLDAMVGHKSPRYLRYGWASARLDDLAGWPGARLTALAAVAAGPDRGGAVRAWRADAAAHPSPNAGPVEASFAGALGVRLGGTLSYAGRVEHRAVLNGERGRPVEVADIERAVRLSRRVTWLALGACVAARALVSRTRRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRQ3</accession>
    <name>A0A0F4IRQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001184">
        <property type="protein sequence ID" value="KJY24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24672">
        <property type="protein sequence ID" value="KJY24672"/>
        <property type="gene ID" value="VR44_34635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16403" checksum="F37302F9987E91FF" modified="2015-06-24" version="1" fragment="single">GESYMAGEWDSDDLAGVLTVLAEHVDELVPAPLRRLRGLWVSRRPAADRNIRVGARVNIQRHYDLSNDLFSAFLDPTLSYSSAVFTAFPARFAALPEAQHRKIDRLLDLAQVGEGTRLLETGTGWGELALRAATRGAHVTTLTLSLIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISJ9</accession>
    <name>A0A0F4ISJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001227">
        <property type="protein sequence ID" value="KJY24443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951742.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001227.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24443">
        <property type="protein sequence ID" value="KJY24443"/>
        <property type="gene ID" value="VR44_35340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4180"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9655" checksum="712070836B34ACE9" modified="2015-06-24" version="1">MALFKKRQVGKPGEWYYCLVHKKVEEGPECPAKDRFGPYTSPEEAAHAMETAQERNLEWQNDPKWNDKTREGQEEGEDTGTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITV6</accession>
    <name>A0A0F4ITV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001287">
        <property type="protein sequence ID" value="KJY24126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24126">
        <property type="protein sequence ID" value="KJY24126"/>
        <property type="gene ID" value="VR44_36275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="33448" checksum="C5792EB01F0F9954" modified="2015-06-24" version="1" fragment="single">MGAVRALGGYAGGVYLRSGTEGLLRMAAVTGLPGPLFRPWWRIQVNRPYPVAEAFRSGQAVHLPDGESAVRRFPQLMAGLPFPFGSLYEPVGSGPERFGVLLVIRAAAPGGAVGAGDGRRIREAAEELGRELAELAAGGDPVCWEGDPLGVPWPVPGGGPGEAVDRLAQGVLSVDRQGVIGFAGAAAARLLGLPVERLLGRGLWEALPWLRHPAYEDHLRGAFLSGEPLFFDARREAGADPAGLSVGLYPGPSGVTVVLEAAERPVFAPGAGARPGAWAGAPAGRAPAQYRPVALAIALTEAMTARQVSAVVTEELLPAFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX3</accession>
    <name>A0A0F4IUX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_32915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001097">
        <property type="protein sequence ID" value="KJY25288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951292.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25288">
        <property type="protein sequence ID" value="KJY25288"/>
        <property type="gene ID" value="VR44_32915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3403"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="36061" checksum="DE8FCF750E1FBC63" modified="2015-06-24" version="1">MPDSTNPPNPPTPPNPPTSADVARLAGVSRATVSYVLNNAEAVRISEPTRRKVRAAAEELGYVPHAAARSLRAGHTRIVLLPTSHVPAGPLYSTFLNELQWALRRLDYTVVQYGSLGLTGDEAVRAWAELRPVAVISLGETALSPHNVDTLKRAGARAVLTLGPERVAGAHALVMDQAEVGALAAAHLAGRGRRRIGVVVPEEPGLDLFSGPRLAGARTVPEVEVTPLALAYTEESAAALAARWGELGLDGVFAYNDEYAVLLMRALLDAGVRVPEDVAVMGADDLLIGRLVRPRLSSVRIEMPSGEWLAGLVDRAVRVPSAMAERYDLTGAAAVPREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVT8</accession>
    <name>A0A0F4IVT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000980">
        <property type="protein sequence ID" value="KJY26122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950917.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000980.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26122">
        <property type="protein sequence ID" value="KJY26122"/>
        <property type="gene ID" value="VR44_30830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2623"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22975" checksum="7E16273FCA9BDF59" modified="2015-06-24" version="1">MGIKDTAETWETLSTRRPFQGAKTAVDSDEVRMPDGSVARRDYQVHPGSVCVLALDGEGRVLVINQYRHPVRRRLWELPAGLLDVPGENPLHAAQRELYEEAHVKAGDWRVLADFYASPGGSDEAVRIFLARDVSDADGERYEDASSEEADMRVEWVEREALVRGVLAGELGNPALVTGVLALTAALASEGGLDALRPAESPWPARPYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW80</accession>
    <name>A0A0F4IW80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000957">
        <property type="protein sequence ID" value="KJY26300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950831.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000957.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26300">
        <property type="protein sequence ID" value="KJY26300"/>
        <property type="gene ID" value="VR44_30390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2490"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="30295" checksum="F44744519422A333" modified="2015-06-24" version="1">MEMHQLRYFAAVVDEGTFTGAAHRLHVSQSGVSTQVAKLERELGHALFDRSGRQVRLTPAGEAVLPLAKSALATLDAIRHTAAEFADAVRGRVRLGMVMGCSIPPFLDTLADLGRSHPGIELGLHEGHSEDLQSQVLAGSLDLALIGYAGEAAGGLEADVVIDEPIAAVVPAGHPLDRTELPLAALRGEKVLCLPPGTGIRAAYEDSCRRAGLDPRVDLEASSPAALLRLAERGAGVAVLSASSAQGAGVRAVPFADAATHARLGLVTRPGQHSPAARLLRTRLLAALRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX02</accession>
    <name>A0A0F4IX02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_29740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950715.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7408"/>
    <dbReference type="EnsemblBacteria" id="KJY26575">
        <property type="protein sequence ID" value="KJY26575"/>
        <property type="gene ID" value="VR44_29740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2327"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="97"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="432" mass="45002" checksum="358D6133BFD71EC6" modified="2015-06-24" version="1">MAAQTVATSANASAADASVDLGPATGLSCRECGTRFELGPIFACVECFGPLEVAYELPAGDPEALRAAIEAGPNNIWRYAPLLPVPADVASKPSLNPGFTKLVDAQNLAKELGVTGKLYVKDDSGNPTHSFKDRVVAIAVEAARAFGYTTLSCSSTGNLAGAVGAAAARAGFRSCVFIPHDLEQGKVVMAGVYGGDLVGIEGNYDDVNRFCSELIGDPLGEGWGFVNVNLRPYYGEGSKTLAYEICEQLGWQLPDQLVIPIASGSQLTKIDKGLQELIKLGLVEDKPYKIFGAQAEGCSPVSTAFKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGGFVEDVNDEQVVEAIRILAQTEGIFAETAGGVTVGVTKKLIENGVLDPSLTTVVLNTGDGLKTLEAVSGTGQTATIRPSLDAFRAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX53</accession>
    <name>A0A0F4IX53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_30600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000968">
        <property type="protein sequence ID" value="KJY26229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950870.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000968.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26229">
        <property type="protein sequence ID" value="KJY26229"/>
        <property type="gene ID" value="VR44_30600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470352" evidence="3">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="65"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="40309" checksum="474988F3949F896C" modified="2015-06-24" version="1" fragment="single">MTKRTRRTLALLSAALLSAAAAGCSTTTGGRPAPARLGSSAAGAPAGTAGSASPAAPGGGARGFTLVASGDVLPHTSVIQRASADAGGDGYDFRPMFSAVKPVVSAADLALCHMETIYGDDDGPFSGYPAFVSPPAVADALKDAGYDGCSTASNHTLDDGAEGLKRTLDRFDKVGLGHAGSARTAAEAARTTLYSAGTAKVAHLAYTYDTNGYPMPDGQPWAVNLMREDKIVADARAARKAGADVVLVSLHLHWGTEWQTEPDETQLSLGKALTASQTGGRPDIDMILGTHAHIPQAYEKVNGTWIIYGMGDQVAGEMFNHTGARDMRGNYGSIGRFTFAPPAAPGQRWQVTKAEFVPQMMDLSTGRVVNLPAALAQDPGNAEYEGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX67</accession>
    <name>A0A0F4IX67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001098">
        <property type="protein sequence ID" value="KJY25276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951298.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25276">
        <property type="protein sequence ID" value="KJY25276"/>
        <property type="gene ID" value="VR44_32935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3407"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="29262" checksum="A6A1BB874B814903" modified="2015-06-24" version="1">MLSARSLFQEIVDHDDSFQLFCSIAASGESQGGWENARIAALVPDGLRDLAPKIVRHGADEDKHGRIFRALLRRRGLPAVPVPPETDYTMLLERRGIGLAHDKLRREEPLSEEDIVVYLAHSRVTEQRAADQMGMLLRHFGDHPEVGKAVRVISHDEDNHLAYCHEELLRLARRGHGRTIHRVLRDSALAEIAVHRDVSLAVMEHMGRLLRWPAPKAAALAAGIRGMYAYERFGGWHRMIGLRPPERTDPLGGRPAPAPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXA7</accession>
    <name>A0A0F4IXA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000986">
        <property type="protein sequence ID" value="KJY26078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950932.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000986.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26078">
        <property type="protein sequence ID" value="KJY26078"/>
        <property type="gene ID" value="VR44_30930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2691"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="483" mass="53881" checksum="315D79DBD0D9EAD3" modified="2015-06-24" version="1">MNIDDLSWQARHHGGVYPRMARTLPDLGQVELLVRAARERGDWNCAEAAARELCAAGKCDRALALLDPFAEIGWRPAEWLTAEIMIHQGHGEKALARVRPDATELGDGHVCARHAELLSKAGRIEEAVDVLSPHLGEHWLRSRLVEITEGRGRDDLVLDVLTREAGHMEAAEGAACERCGGSCGTNRTDRWHVLLLISQVLERAGRTDEAVEVLRAERASGRRHPVNFPEYYAELLARQGLIEELGALAAEDHRSALDVYAKALEDAGRADEAESVLREGIATHDHPKDRAALMGLLVRQGRVDEAVETGRPTYEYYDCWNFLQWALELLVEDGRPDRALELLDGQTDEYIKEHPDQVRHLRLWLLGEAGRCKEGISEATALNEREPGEWDTALARLLEQDGRTEEALALLRSSTHYSVHHELPDVLIRHGRLAAALDAIPTIAESRAASEQRKREREREAAEQREQDDPWAATGGFSVEPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXM5</accession>
    <name>A0A0F4IXM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950624.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000904.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26790">
        <property type="protein sequence ID" value="KJY26790"/>
        <property type="gene ID" value="VR44_29240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046000">
        <property type="entry name" value="DUF5956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19381">
        <property type="entry name" value="DUF5956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18275" checksum="CE30D0A7EC9B87F1" modified="2015-06-24" version="1">MSWDAGGSPHRQAGRRSGRSELEADRLPEVRELGELGWVLAPEAPMWVFLPFVWPSHARTWVPDRSTRWQIDTTTDGSGRVVEAECHPVTETEQETQEKDASADLAGVGIPPRPSGRLWLLRPVGGFEDLDAVLDHLCAQAEARGVPVGLSAAFAALCAAELEAAADAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY35</accession>
    <name>A0A0F4IY35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iso_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000885">
        <property type="protein sequence ID" value="KJY26930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26930">
        <property type="protein sequence ID" value="KJY26930"/>
        <property type="gene ID" value="VR44_28870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2114"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21073" checksum="CC5FA25850D646D0" modified="2015-06-24" version="1" fragment="single">MSTLAVIPGDGIGPEVMAEVLKVHAVVEDVFGTGLKTEVLPYSADWFLEHGDVEIDIQAIRRDHRAVLLGALGDARIPDNRHAIRVIGGLRQQLELGVNLRPVRLRALAHCPLKHVGAVEDVDLVIVRENTEDVYVGVGGTVRGGGPGHVAMEVGVHTRWAVDRVVTAAFELARSRRRRLTLVDKSNAMPSAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY45</accession>
    <name>A0A0F4IY45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000883">
        <property type="protein sequence ID" value="KJY26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950539.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000883.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26940">
        <property type="protein sequence ID" value="KJY26940"/>
        <property type="gene ID" value="VR44_28780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2096"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005469">
        <property type="entry name" value="Avidin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017889">
        <property type="entry name" value="Avidin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036896">
        <property type="entry name" value="Avidin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005468">
        <property type="entry name" value="Avidin/str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01382">
        <property type="entry name" value="Avidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00709">
        <property type="entry name" value="AVIDIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50876">
        <property type="entry name" value="SSF50876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00577">
        <property type="entry name" value="AVIDIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51326">
        <property type="entry name" value="AVIDIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0092">Biotin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470240" evidence="4">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605468-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="18649" checksum="A3C107E66D77EC1D" modified="2015-06-24" version="1">MRKIVVAAIAVSLTTVGIAANASADPAKDSKAQVAAVDAGITGTWYNQLGSTFTVTANTDGSLTGTYESAVGNAESRYVVTGRYDTAAATGTGTALGWTVAWKNDFRNAHSATTWSGQYVGGADAKINTQWLLTSGTTAADSWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYH2</accession>
    <name>A0A0F4IYH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951086.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene95"/>
    <dbReference type="EnsemblBacteria" id="KJY25726">
        <property type="protein sequence ID" value="KJY25726"/>
        <property type="gene ID" value="VR44_31770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3065"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="35255" checksum="5BA3BF8D09DAD2E6" modified="2015-06-24" version="1">MQPIIIVLIILVVLVFIALVKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILQAEGVRQSEILRAEGEKQSSILRAEGEAKAAALKAEGEAQAIRTVFESIHAGDADQKLLAYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAMGNFGPLGGGSAGFNPQNPGKGAPEAASGPERREQPPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYY2</accession>
    <name>A0A0F4IYY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="14" type="ORF">VR44_28165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950428.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000858.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2560"/>
    <dbReference type="EnsemblBacteria" id="KJY27212">
        <property type="protein sequence ID" value="KJY27212"/>
        <property type="gene ID" value="VR44_28165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1877"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="65"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="294"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="806"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="728"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY27212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="956" mass="105734" checksum="DD21659115FE15E4" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0H6</accession>
    <name>A0A0F4J0H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950173.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3178"/>
    <dbReference type="EnsemblBacteria" id="KJY27775">
        <property type="protein sequence ID" value="KJY27775"/>
        <property type="gene ID" value="VR44_26765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1511"/>
    <dbReference type="eggNOG" id="COG3573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="539" mass="58389" checksum="809119261420D23A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0N6</accession>
    <name>A0A0F4J0N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000792">
        <property type="protein sequence ID" value="KJY27845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950147.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000792.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1161"/>
    <dbReference type="EnsemblBacteria" id="KJY27845">
        <property type="protein sequence ID" value="KJY27845"/>
        <property type="gene ID" value="VR44_26630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1451"/>
    <dbReference type="eggNOG" id="COG5426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046306">
        <property type="entry name" value="DUF6421"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19985">
        <property type="entry name" value="DUF6421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="468" mass="52804" checksum="758CD0F7E7797E22" modified="2015-06-24" version="1">MTETLVPGIGGAVITAGARVVDHPAWPELKAAVEEIRPWQAKDGSIDFEAEGAPAPVEVEAVVERVVAGVETLSPLLPHAAAYHKALVADLRKWAAEGFGVPDFLDSLLAFQPAAQREDGLQHLVVFPMYTQNGNLDRNLEAVVLKMVWPDWLAELERTRYDNPLFLGITFEDFTPGYDTNSAVLFPETIAVREAPERFTWGGIFCDREAARYRKVTEAAVDILGIELPEDIARMVEDQERCEKAFVLWDMVHDRTHSHGDLPFDPFMIKQRQPFWMYGLEELRCDLTAFKEAVKLESEGNEHGRDVQYAVLFDRMFRFPVSGDRNRNYDGLGGQLLFAYLHKHDVVRWTDNKLKIDWMRAPQVTNQLCAEIEDLYRAGIDRPKLVHWFKAYELVSTYLAPHPGSKWAKGPDALDLTQPPRKLVDDVLPDEFPLSMFYEALAKKLKGVIASTKGITPQNADDASRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J101</accession>
    <name>A0A0F4J101_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000820">
        <property type="protein sequence ID" value="KJY27559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950270.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000820.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27559">
        <property type="protein sequence ID" value="KJY27559"/>
        <property type="gene ID" value="VR44_27285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1594"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12371" checksum="F63A2CBE792D90AF" modified="2015-06-24" version="1">MTDNALPPCPECSGVYAYEMGALLVCPECGHEWPLAAAPEAGDAPAERVIKDAVGNVLADGDTVTVVKGLKVKGHPTGIKAGTKVRNIRLVDGVDGHDIDCKIDGFGSMQLKSSVVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J141</accession>
    <name>A0A0F4J141_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000832">
        <property type="protein sequence ID" value="KJY27453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950310.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000832.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27453">
        <property type="protein sequence ID" value="KJY27453"/>
        <property type="gene ID" value="VR44_27520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1671"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470028" evidence="2">
        <location>
            <begin position="37"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="485" mass="51391" checksum="17C700CE4B610F51" modified="2015-06-24" version="1">MPLSRRDFTARTALAGAGVALTGTVGALATAPGALAADEPGPGAADAAEGHGRPHAPGYGPLLPDPAGLLALPAGFSYRVITHSGVTTLDSGESTPSNHDGTAAFEGARGVTLLVNNHELKGPRANWTHPVPLTEGLVYDPAASGGCTVVEVRRGGEVAEWVGVAGTSTNCAGGATPWGTWLTCEETEDLAGKNGMTKDHGYVFEVDPHDRRANRDPRPAKAFGRYAHEAVVIDPRQGHAYLTEDASGPNGLLYRWTPPEGFRHGRGRLRTLAADAGVLAAAKCFDKAGQFVDDLSRATRTGTVYGVDWVEVTDRDARTLSVRKQFAAGAVTRARKLEGMWWADGGAYFVSSYAREESPGAAHDGQVWFYDPRRRTIRLVVLIGVNADPDAEGGYDGPDNITVSPYGGLVIAEDGNGLQHLLGATESGRVYPLARNELNIGTPEKPEYSEFTGVCFSPDGRTLYANIQEPGIMLAITGPWRRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J192</accession>
    <name>A0A0F4J192_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000769">
        <property type="protein sequence ID" value="KJY28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950070.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000769.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28032">
        <property type="protein sequence ID" value="KJY28032"/>
        <property type="gene ID" value="VR44_26220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1404"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8591" checksum="47E9B9EBE5B5CDA0" modified="2015-06-24" version="1">MDRFHDRDLNVRKERLRDFGAVDAGMVEMEPGRLVLIVRMPRHFPDGQTQDRLKEQVQGLPGVVDVRVCTFHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2I6</accession>
    <name>A0A0F4J2I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_28375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950462.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000866.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27146">
        <property type="protein sequence ID" value="KJY27146"/>
        <property type="gene ID" value="VR44_28375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2000"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="24776" checksum="F404A92FE62397E7" modified="2015-06-24" version="1">MSTVRGARERARIEVTAAIKDEARRRLADEGAAKLSLRAVARELGMVSSALYRYFPSRDELLTALIIDAYDSLGAAAEAAGAAALAAGSPPRARWTAVCEAFRAWALAHPHEYALIYGSPVPGYSAPQDTVVPASRVANVLIGIVRSAHEGRGLALPPLPATLRAEAGRMTAEFAEGLPPEVTAALVAAWAQLAGLVSFELFGQFNNVVEERDAFFAHAADQLAHAVGLPALGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2W4</accession>
    <name>A0A0F4J2W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZIP family zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000719">
        <property type="protein sequence ID" value="KJY28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949855.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000719.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28555">
        <property type="protein sequence ID" value="KJY28555"/>
        <property type="gene ID" value="VR44_25075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1105"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="24651" checksum="BF1397A220E37CFC" modified="2015-06-24" version="1">MVGALVAGGWGLFAGAALLIGAAIGSFVRVPPRWIALVMAFGSGVLLSAVSFELIAEAYERSGIGPVVWGAAGGAAVYSGVNALLARRGAQHRKRSGQEQPSESEAPGSGNAIALGALLDGVPESVVIGTSLLGGSHVGTATVAAVFISNLPEGLASAAGMRSAGRTRRYVFALWGGIALISGLAALAGYALLGGASEAVMAVITAVAGGAILAMIADTMIPEAYSKVHLLTGLVTVAGFLSAFALAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3B8</accession>
    <name>A0A0F4J3B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_27645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000839">
        <property type="protein sequence ID" value="KJY27401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950332.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000839.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27401">
        <property type="protein sequence ID" value="KJY27401"/>
        <property type="gene ID" value="VR44_27645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1764"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="34038" checksum="BF1C26C9E814064A" modified="2015-06-24" version="1">MAGRDGETRVTVWVALAANLVICAAKAVGGVVAGSPALLSEAAHSVADSLNEVFLLASVRRSRRPADERHPFGYGKERFFWSLLAAVGIFVTGGCFSVFQGVEALRGGGETHEGYAIGLAVLFVALLAEAGSLLRAVLQVRRAARAAGHGVAEEVREGRDPALRTVLAEDGTACLGVLLAMAGMALHLATGQVAYEACASILIGVLLVYVAYVLGKGARTHLIGEAADPRLRDEVHAYLDGQPEIDSVTALLTMRLGPDAVLLAAGIDLTAGYDSETVEDAMVRVRTELKRRWPELDQVFLDVTDAAAARNVKSSPKRPSGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3P0</accession>
    <name>A0A0F4J3P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000690">
        <property type="protein sequence ID" value="KJY28947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28947">
        <property type="protein sequence ID" value="KJY28947"/>
        <property type="gene ID" value="VR44_24095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.812"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="34183" checksum="F1BE7B081A0BEF39" modified="2015-06-24" version="1" fragment="single">LLDTLVAAPGIRDDARSALLWLLIAAPVRLAQFVGAMALFALRRSRPLLTLYAVAVVANAALDWFFVHGAGLGFAGAYAATSVIAALECAVTVWLLRDHLSLPLRLRDSARWLRQVARSMVTEWGHMLSVIGFELLLVLALTLKASWGDRLAAFSAGAVLTATLHIPLTALVNATGMVCKDAAPTAREWRGLRGGVLAVSGAVCGLVAAAAWTVLPGFYGLHGTAATWFTWLMAAQAAAFPFRLLAATAEGRHKAADRFGVVLRLRLLQEFGIALPLFATGLLTDNAAVAWSGLVAGAAVNYWLLRGGGTTPGREATADRHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4U9</accession>
    <name>A0A0F4J4U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29280">
        <property type="protein sequence ID" value="KJY29280"/>
        <property type="gene ID" value="VR44_23315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="37954" checksum="1F55A97560A4D9EE" modified="2015-06-24" version="1" fragment="single">MDSSDQGDPASRTGAHRAHRRTPRAGAPEPEETPAVTTSAFPRPAGTTDQAASADPAALAPPPAPADAAAAVRSGDPETPPSPYEPYLDGLFTYCLSVLCDHDAATDVLGDVLAVADRHPGRCPDEGDRRAWLYALARWACLRRLAEQRRARQGAHSTRRTPEHAEAGHAPQAHLPYRSRDVLDVDAYRRTELARLAWPEAAGTTPEQREALELAVRHRLGVTELAAVLGTAPATARELLSAAACEVERTRAALAVVETGNCPAVSRLTGEDGDRDVLLSSSLRAELVRHVDDCPRCRRVAERVGATAPWPGSGGLHAALPLVAAPRGAVRAAMLRSGRRRGGRPGPRFDRTGFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4W1</accession>
    <name>A0A0F4J4W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27921">
        <property type="protein sequence ID" value="KJY27921"/>
        <property type="gene ID" value="VR44_26475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1480"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13472" checksum="29A3B4F5DA545AB2" modified="2015-06-24" version="1" fragment="single">MFTAPDPGRARLRNSARAVIGTGLAVAVAELAGLSLTASITGGLAALLALFTVLDADVRAQRVTTALLPVAGFPVLALATSLHGMPPVRDAAWLAVVFAGVYARRWGPRGHALGIFAFMMFFVTQFLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4W4</accession>
    <name>A0A0F4J4W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949484.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29412">
        <property type="protein sequence ID" value="KJY29412"/>
        <property type="gene ID" value="VR44_23010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.539"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10989" checksum="B5FFC2A1C27F74CE" modified="2015-06-24" version="1">MSSVGSPEFRHRSTVGRAFVGVQDTAAYLGISPKTLYVWRHRRQGPPSFRMGARGRVTYRVDALDAWIRAQEQADSRSNPDLNPVSAAPQRRAAYSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J543</accession>
    <name>A0A0F4J543_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_26260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000771">
        <property type="protein sequence ID" value="KJY28016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28016">
        <property type="protein sequence ID" value="KJY28016"/>
        <property type="gene ID" value="VR44_26260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1540" mass="159119" checksum="194DF1178215010B" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6P1</accession>
    <name>A0A0F4J6P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29885">
        <property type="protein sequence ID" value="KJY29885"/>
        <property type="gene ID" value="VR44_21695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.218"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470429" evidence="2">
        <location>
            <begin position="31"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="259"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="458" mass="46898" checksum="C6EA9C975299CB83" modified="2015-06-24" version="1" fragment="single">MPSRRIAAATAALAAAALVSPLLLAGPAGASGPQSDAARGEALARKLVKEATGKGANNHLKVFQSIADYNNGTRVAGSKGHEQSAKYVEGVLKAAGYEVSRNEFDFVYVETIAETLKVNGANGRDVPLKLMTYTASGPEGGITAPVAVVPVDADGSNGCDAADFAPGAFTGKIALVKRGGCTFATKQANAAAAGAVGAVIYNNTAGSLNGTLGDPNVGKVPTGGISQADGEKLAAEAAAGPVEVTLDVRQFRENRKTWNVIAETKGGDPENTVFLGAHLDSVAAGPGINDNGSGSAGILQVAQRLAGEQKKIKNKVKFAWWSAEEFGLLGSEAYVASLTPEQKKQIKLYLNFDMIASPNAAYFVYDGDDSDKVGSGPGPEGSAQLEKQITDFLDAQKIPHEGSDFTGRSDYGPFIEAGIPSGGTDTGAEGIKTAAQAAKFGGQAGVAYDVNYHGKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7K3</accession>
    <name>A0A0F4J7K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000584">
        <property type="protein sequence ID" value="KJY30175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30175">
        <property type="protein sequence ID" value="KJY30175"/>
        <property type="gene ID" value="VR44_21065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8892"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="13166" checksum="30A9C8DDA1D7672C" modified="2015-06-24" version="1">MAPADYRLPVWFFGFEGVLAAAFDIIKAFPSAWPVLLGLLVVNIAVSLTLMRRRLKLAKALWRALVALRVGSHFALNALGFAVTSTLGHAVFAVVMAAVTIGLLAYSQETAVRALTRTPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7S2</accession>
    <name>A0A0F4J7S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29849">
        <property type="protein sequence ID" value="KJY29849"/>
        <property type="gene ID" value="VR44_21800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6869" checksum="07C6F7C906E6A3EE" modified="2015-06-24" version="1">MRSAPSAGEWARAWGPGRVRSPAPRPPRSARQRAVPSCRPLVRPPRRRPRPGPRRARGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J851</accession>
    <name>A0A0F4J851_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_20135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30567">
        <property type="protein sequence ID" value="KJY30567"/>
        <property type="gene ID" value="VR44_20135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8732"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="31205" checksum="489C9E4FC1681CE0" modified="2015-06-24" version="1">MRSRALEAGPPDAGAGTPGALVVVGDVVTDVVAVHREPLAPATDTAARIRTLPGGAGANAACWAARTGTAEVRLLARVGCESARWHERALVDAGVRPRLVVDPAEPTGTVVALVGADAERTFLTDSGASLRLCPADWAPALLDGAAHLHLSGYLFFAEPSRELALVALRAARTRGVPVSVDPASAGFLAGLGPEAFLSAVAGVSVLLPNEDEARLLAGVRDTARAAESLSRRFPLVVVTRGTGGALVAEGGRITAEVEAEPADAVDTTGAGDAFTGGFLAARLSGAAPAASARAGCRAAARAITRLGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA15</accession>
    <name>A0A0F4JA15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000523">
        <property type="protein sequence ID" value="KJY31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948751.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000523.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31025">
        <property type="protein sequence ID" value="KJY31025"/>
        <property type="gene ID" value="VR44_19090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8422"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010866">
        <property type="entry name" value="A-2_8-polyST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07388">
        <property type="entry name" value="A-2_8-polyST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="38148" checksum="160073FB02823764" modified="2015-06-24" version="1" fragment="single">MNVTQVFLASTLYGTATLAAALDAGCLPPAGRRILLTSNHSPAPEVTPGLDSMPGFAALRTRFDEVLDWNAVVAPQHPSAWAPRPEDVPLWERQLRRLWGLGRDRVELVVESLQVPPAQSLCRLFPGAAIDVYADGLMSYGPTRFRIDPQIGMRVRRVLHLDLVPGLEPLLLTEFGVRGELVPAPAVLKVLTELADLAEPLGPSTGEGAGDGSGEEPPALLLGQYLSALDLMSPDEEEELHAAMVRGAYEWGHRDLVFKPHPSAPGAYARRAVAEAGRLGVRLRVLDAPVLAETLYQRLRPALVVGCFSTGLLTARALYGIPVARTGTGAVLGRLAPYQNSNRIPLTLVDALVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA41</accession>
    <name>A0A0F4JA41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_18520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948642.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7338"/>
    <dbReference type="EnsemblBacteria" id="KJY31237">
        <property type="protein sequence ID" value="KJY31237"/>
        <property type="gene ID" value="VR44_18520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8299"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="25233" checksum="94A627EFD1F2417C" modified="2015-06-24" version="1">MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVAVASDRHLELTDEGRKLATRVMRKHRLAECLLVDVIGLEWEQVHAEACRWEHVMSEAVERRVLELLRHPTESPYGNPIPGLEELGEKAEADPFIEDGMVSLSDLDPGSEGKTVVVRRIGEPIQTDAQLMYTLRRAGVQPGSVVSVTESPGGVLVGSGGEAAELDSDIASHVFVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA58</accession>
    <name>A0A0F4JA58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949264.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29861">
        <property type="protein sequence ID" value="KJY29861"/>
        <property type="gene ID" value="VR44_21865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.253"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11318" checksum="AB88D1048555D66A" modified="2015-06-24" version="1">MSAHGYDEGHTVAGWAGTAVAAVGAGVIGLGVCGWTPGIWIGAAVMAAAAVLTWVLHLAGWGKGPGPRPRAHWPMGVRDHAAREGHAECLGCRMAGRRPEPAVAVAAVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAH5</accession>
    <name>A0A0F4JAH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic ring-opening dioxygenase LigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000497">
        <property type="protein sequence ID" value="KJY31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31377">
        <property type="protein sequence ID" value="KJY31377"/>
        <property type="gene ID" value="VR44_18275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8203"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="44787" checksum="850DF56427E08169" modified="2015-06-24" version="1">MTVPAGSTTQADRCSAIRVPGAEYSVSSCLADLTTTGTQLTGHTDPKDWEGLIVPGTPTPAGAPGVQIDGYFPDTSTTNTNHGWNHDSQFVIRLPKNWNGGLVVAGPPGTREQYANDPIISDQVLAKGYAYAATDKGNTGDELYKDGDRPGDAIMEWHRRVTQLTVAAKKVTDQYYGRTPRVTYVAGLSAGGYLVRWQLEHHPELYTGGIDWNALTFTKEGSLLTALPPALRAYPRLAKGDRSAYDEILAAGYPKGSEKQWGYHYNKQWDLLQRVVREELDPDYDGATRGGTPFCPAGTGPGCDTDYDFASRPEAVHRAVERISLTGNIKRPLISIQGTLDALTPPATFGDVYDRMVTDAGRASLHRYVHVPGGTHTDGLVAIDKETYRPMLPSFVAAFGELETWTGPTTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBJ3</accession>
    <name>A0A0F4JBJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000517">
        <property type="protein sequence ID" value="KJY31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948710.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31108">
        <property type="protein sequence ID" value="KJY31108"/>
        <property type="gene ID" value="VR44_18880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8390"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="161"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="28406" checksum="EFFB2FA3326A0FD7" modified="2015-06-24" version="1">MTAILSASALMDELAAGHPPVLLDVRWQLGGPDQRPAYEAGHLPGAVYVDLDRELAGPPGAGGRHPLPDPEEFGAVMRRAGVRADGPVVVYDGGQGWAAARAWWLLRWTGHPNVRVLDGGLAAWTAAGGPVTADAPTPAEGDFKPNPGALGLLEADDAAALARTGLLLDARAGERYRGEVEPIDPVGGHIPGAVSAPTTENVGPDGLFLPAEALKARFTELGAATDTQVGVYCGSGVSGAHEVLALEVAGIPAALYAGSWSHWSSDPQRPVATGPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC62</accession>
    <name>A0A0F4JC62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_17135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in acetate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">In the N-terminal section; belongs to the CobB/CobQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="5 11"/>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948378.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3061"/>
    <dbReference type="EnsemblBacteria" id="KJY31922">
        <property type="protein sequence ID" value="KJY31922"/>
        <property type="gene ID" value="VR44_17135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7959"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016475">
        <property type="entry name" value="P-Actrans_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006107">
        <property type="entry name" value="PhpActrans_proteobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="13">
        <location>
            <begin position="209"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="12">
        <location>
            <begin position="366"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="696" mass="73695" checksum="DB64E32952DD02B1" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM3</accession>
    <name>A0A0F4JCM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPP family protein+B94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948514.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000483.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31559">
        <property type="protein sequence ID" value="KJY31559"/>
        <property type="gene ID" value="VR44_17880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8119"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="175" mass="17482" checksum="F43B14102E656A01" modified="2015-06-24" version="1">MPASRTSTQESPSRAWVSKAPPRPGWGAVATATAASVTGLVALVAAGKALDQVLLIPPLAASAALVYGAPGLPLSQPRSVIGGQFLSAVTGFVVLWAAGGSAWAAAVAGGLALGVMQLARTPHSPAAATAVIVVATKPDAALFLPLLVLATAVLVLIGIIAGRTRAGSRYPAYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDK6</accession>
    <name>A0A0F4JDK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948415.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31838">
        <property type="protein sequence ID" value="KJY31838"/>
        <property type="gene ID" value="VR44_17330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8001"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6342" checksum="289A0478398EFF4F" modified="2015-06-24" version="1">MSTATLTPIQGGRPSGATATSSHHPRHRVGDVLRAVKVFATAAVSVVVLGEYSEDAGVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDW0</accession>
    <name>A0A0F4JDW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030158619.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31979">
        <property type="protein sequence ID" value="KJY31979"/>
        <property type="gene ID" value="VR44_16965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7923"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="10866" checksum="B296AC2076C1459E" modified="2015-06-24" version="1">MAWVLLLVAGLLEVGWSIGMKFTEGFTRLWPSVFTGAGIVASMVLLSYAAKTLPIGTAYGVWVGIGAAGAAVLGMAVLGEPVTAARIFFICLLLVAVVGLKATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE47</accession>
    <name>A0A0F4JE47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000410">
        <property type="protein sequence ID" value="KJY32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948148.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000410.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32465">
        <property type="protein sequence ID" value="KJY32465"/>
        <property type="gene ID" value="VR44_15910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7591"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16615" checksum="463A3E75A4AB50A2" modified="2015-06-24" version="1">MGGMPLNDMPWWRWRSNVRSALHMLSDPVFQEEVWLAGAEGYGDVTDAVYRLVEDTWLDSWSADKYIGTIFRDAQEAALVDLAVLRVLRILHQVGPDAPVTAYLEHSAWPEAVRAAREAHVRMSAADGEDPDDRPSSVEVLKILTRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEK1</accession>
    <name>A0A0F4JEK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000433">
        <property type="protein sequence ID" value="KJY32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948248.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000433.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32183">
        <property type="protein sequence ID" value="KJY32183"/>
        <property type="gene ID" value="VR44_16445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7686"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="9935" checksum="5052D9CE05166D0F" modified="2015-06-24" version="1">MQTDTTPGELTDRVRAIWAEVLGRSDFSDSESFFETGGHSLLASKVMARLGRAVGTRLSMQLIFDHRTVEQLAAAVQAQLAAGAAAAAPETTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF92</accession>
    <name>A0A0F4JF92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000477">
        <property type="protein sequence ID" value="KJY31656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31656">
        <property type="protein sequence ID" value="KJY31656"/>
        <property type="gene ID" value="VR44_17685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9199" checksum="95D4649863BA1FDF" modified="2015-06-24" version="1" fragment="single">MALAGRVSTHPGWMGRSASKTVPSVMVRPWLRAAMSVHRSPLPSVCWAMDHRLSAGRTSRTVYVTAVLDALAGVPACGAASLPEPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHK3</accession>
    <name>A0A0F4JHK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000413">
        <property type="protein sequence ID" value="KJY32421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948166.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000413.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32421">
        <property type="protein sequence ID" value="KJY32421"/>
        <property type="gene ID" value="VR44_16015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7623"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="21821" checksum="23B3B3FB6532E9A1" modified="2015-06-24" version="1">MRTDLRISWEIPATPSGLAGRLERFMGPGKSRSESVVETIGLLGCALLLAAGLWSSGAARDWSTGQLAVVALAGLDLIGGVLTNATNAAKRWYHRADPAARRARLLFVSAHLIHLAAMGLYVLSGDLAWTSANAGLLLGGSVAVEFAPVHLRRPVAMAVLMAAVLVNLFWLPVPAALAWFVPLFFLKLLVCHLVPEAPLERGRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI32</accession>
    <name>A0A0F4JI32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000403">
        <property type="protein sequence ID" value="KJY32621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948097.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000403.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32621">
        <property type="protein sequence ID" value="KJY32621"/>
        <property type="gene ID" value="VR44_15635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7528"/>
    <dbReference type="eggNOG" id="ENOG50347P2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="8561" checksum="0F3C764CDDC3D44B" modified="2015-06-24" version="1">MTVTPHPDEARPGDGLVKAGGIVFIVGAVATLVTMAPLFLGTDPFPSYAWAVCMLMGVGFMISAAGVLRSAAAQRRAARASQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI76</accession>
    <name>A0A0F4JI76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000317">
        <property type="protein sequence ID" value="KJY34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34047">
        <property type="protein sequence ID" value="KJY34047"/>
        <property type="gene ID" value="VR44_12695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6618"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="30278" checksum="1C40ABEA61BD9CD7" modified="2015-06-24" version="1" fragment="single">LYEPPAPVRVRRPEIPQELEALLMRLLAKDPQDRPGSAQEVYEALAPLLPAPGSRPVAGPLDPTRPFLRPQAPWPDRQAAGGVPPMPATAPAPPRPDIPGAVDEARKLLDQGRLTQAVDILGGILPAAAAEHGEHSPVVRSLRKQYAATLMDDGQYRRALPELRRLADEFPAGDPQALRLRYDAAQCLEQLGEPAAALAEYRSLLPLFENHYANPDPGLPLEVRRRIAHLLLSLGDRAAAHDTLVRLLYDADRVHGPAHPLPVDIRRTLQWLGQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI81</accession>
    <name>A0A0F4JI81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947781.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33509">
        <property type="protein sequence ID" value="KJY33509"/>
        <property type="gene ID" value="VR44_13855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7050"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="287"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="526" mass="55206" checksum="792D2CC3F8332C4B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIC9</accession>
    <name>A0A0F4JIC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_15295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000396">
        <property type="protein sequence ID" value="KJY32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948032.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000396.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3261"/>
    <dbReference type="EnsemblBacteria" id="KJY32726">
        <property type="protein sequence ID" value="KJY32726"/>
        <property type="gene ID" value="VR44_15295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7461"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="20007" checksum="5A707E7034E0B551" modified="2015-06-24" version="1">MQWTNLSEQTVYKNRWFDVNLADVELPDGRHLDHFVIRLRPVAVATAVNEADEVLLLWRHRFITDSWGWELPAGVVEDGETVEAAAAREMEEESGWRPGPLHHLMTVEPSNGLTDARHHLYWADGATHIGEPEDGFESSRREWVPLKLVPDMIGRGEIPAANMAAGLLLLHHLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIW2</accession>
    <name>A0A0F4JIW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32901">
        <property type="protein sequence ID" value="KJY32901"/>
        <property type="gene ID" value="VR44_14985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7414"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="258"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="36086" checksum="57FC647942368997" modified="2015-06-24" version="1">MPPPLTLSLSTADLSRLRWAVSPAWELLASIRTLTRPARHVIHMPWLSEHRHDPLLAGPVTSAAYDLTAGPASHLPGFLAPTPLSPLTALDEELDEVRRTPADVVRRDLTAVFGDDLPATLAPMLQAPGRELETIVADLSRYWQRTLAPVWPRIRALLESDIHYRARSLTERGPAAMFADIHPDLAFDQATGTLRIARRRPALLDPHRPLEGRGLVLVPSAFAWPSLYFKTAEPWVPVIRYPVRGVGTLWEPPAGTADLAPALGATRARLLDLLETPASTLELAHRTGLAQGGVSAHLHKLTQAGLIAPHRTGRIVLYSRTARGEALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ76</accession>
    <name>A0A0F4JJ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000334">
        <property type="protein sequence ID" value="KJY33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2343"/>
    <dbReference type="EnsemblBacteria" id="KJY33833">
        <property type="protein sequence ID" value="KJY33833"/>
        <property type="gene ID" value="VR44_13125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6688"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="24131" checksum="EA1E87350B445AB7" modified="2015-06-24" version="1">MREISLRVTRLLVTTKVTPNQLTYVMTLSGVLAAPALLVPGIWGAVLGVLAVQGYLLLDCVDGEVARWKQQFSLSGVYLDRVGAYLCDAAVLVGFGLRAADLWGGGRIDWLWAFLGTLAALGAILIKAETDLVGVARHQAGKPVVQESAAEPRSSGMALARRAAAALKFHRLVLGIEASLLILVLAVLDQIRGDLFFSRLGVAVLAGIALLQTVLHLVSILASSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK25</accession>
    <name>A0A0F4JK25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947514.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34169">
        <property type="protein sequence ID" value="KJY34169"/>
        <property type="gene ID" value="VR44_12435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6546"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17312" checksum="408395086233194F" modified="2015-06-24" version="1">MPEPDLGDFAVAQDGPLYVVTAAADGMRAGCLVGFASQCSIDPPRFVVWLSVENHTYTVARRARYLTVHVLRRDQEALARLFGGRTGDRTDKFAGIGWRPGREGSPVLAGVAAWFTGRIEAVVAGGDHEGFLLAPVEDGPPAPGPAAPLRFGHVRDLEAGHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK80</accession>
    <name>A0A0F4JK80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">VR44_11465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947333.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34742">
        <property type="protein sequence ID" value="KJY34742"/>
        <property type="gene ID" value="VR44_11465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6191"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="407" mass="44864" checksum="24E505A1AB1985D7" modified="2015-06-24" version="1">MPFHVDSETGRLKQVILHRPDLELKRLTPTNKDALLFDDVLWVKRAREEHDAFADTLRDRGVQVHLFADLLTETLALPAARTLVLDRVVDEREFGPLAGDRVHAAFDVMDPGELAACLVGGITKRELLARTGAVPSVRLHAMAPDDFVLAPLPNHLFTRDTSCWVYDGVSVNPMRKRARRRETVHFEAIYGHHPLFEKGDHQRWSDGQAGFPATIEGGDVLVIGNGAVLIGMSERTTPQAVEQLALRMFAAGSARRVVALELPKSRSFMHLDTVMTMVSGDTFTRYAGLGPLRSCTIEPGHDGQGMKITAHLPEELDGAMADALGLEKINVLTPSQDIRSAEREQWDDGCNVLAVEPGVVVAYERNVTTNTHLRRNGIEVITIRGSELGRGRGGPRCMTCPVEREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKV8</accession>
    <name>A0A0F4JKV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947271.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34962">
        <property type="protein sequence ID" value="KJY34962"/>
        <property type="gene ID" value="VR44_11120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6108"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470653" evidence="3">
        <location>
            <begin position="35"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="42112" checksum="CCF13624F421EDC6" modified="2015-06-24" version="1">MTNPPPARRSVLRTLLGFGALALGAAACGPADDAAERPGTPANTPEQASANGAKRRLGAEWESHTRTFMAWPAIAAGVWDKDLPYVREDIARIARAVGAYEAVVMMARPDQVDAAQRACGNQVEVIPLAVDDLWARDTVPVFVEEAGRTVGVDFNFNGWGGKQQHGNDAQVGRTLLQKYGIPRVQAPLVAEGGSFETDGEGTLLVTESSIVNDNRNRGKSRNTIEAELKKTLGVEKVVWLAGVRGQDITDAHVDSLVRFTAPGVVLLDRAHPNTPPDSWSRSADQAKSVLSRATDARGRRLEVIDLPQPDLDRITGRGDDFVSTYANFYVANDAVFMPRFGDRQADDRARGILREHFPKREVVQVRIDTIASGGGGIHCSTHDQPGKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLD6</accession>
    <name>A0A0F4JLD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_10730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947194.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35157">
        <property type="protein sequence ID" value="KJY35157"/>
        <property type="gene ID" value="VR44_10730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5894"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22847" checksum="24504CE10C982073" modified="2015-06-24" version="1">MTISSALLSFAVVAGMLTIMPGLDTALVLRSAITLGRRRAFATALGILCGVLVWGMAAAVGASAVLTASRLLYDALRVAGAVYLAWLGIGMLRRTLKERRRPASADPAEGAGAEAAEETWVRSWARGLGTSLLNPKNGVFYMAMLPQFIPSGAPHLLMGAVLAAVHDLEGLVWFSALIFGTQLARRWLDRGSVRRAIDAITGTVLVGFGIKLALGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLF3</accession>
    <name>A0A0F4JLF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947670.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33796">
        <property type="protein sequence ID" value="KJY33796"/>
        <property type="gene ID" value="VR44_13265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6872"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15759" checksum="233D471BBD08FFC9" modified="2015-06-24" version="1">MAFPETRTAVEWLAAAAPDPEACRWEWERGPLGVALLPAGRHWDLLITPGELGRAALGVLRRLPAPPGPVLAAGRTARLGFFVPPGTASHWIGTGVRGAGRGSWIAVPYPGRATGGPSWLRLPDGRGTLTDPALLELALHEAAARALAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMW3</accession>
    <name>A0A0F4JMW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946940.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35707">
        <property type="protein sequence ID" value="KJY35707"/>
        <property type="gene ID" value="VR44_09345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5197"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17728" checksum="1ED4061FB32FDB27" modified="2015-06-24" version="1">MLTPFSAPFFATPTACPVAPDHPAQPAPPDGLSCSMTLPASARSAGIARQAVRAALHAYALDPLEATAVQAASELMGSAWRMDPYGELYLSLRHRDDALRLIVYDGHPAHAQPRLAALCEARRRATLRVFAALVRDHGGEWGVGPSREPGGGTRTWATLPLRVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNE3</accession>
    <name>A0A0F4JNE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000190">
        <property type="protein sequence ID" value="KJY35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35897">
        <property type="protein sequence ID" value="KJY35897"/>
        <property type="gene ID" value="VR44_08935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6283" checksum="C85DD9AF7263D221" modified="2015-06-24" version="1" fragment="single">MTPDLDLLLSVLRALTPILLAALGGAICERAGVFNIGLEGMMLIGCFSAVATSWFTGSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNE7</accession>
    <name>A0A0F4JNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946952.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35720">
        <property type="protein sequence ID" value="KJY35720"/>
        <property type="gene ID" value="VR44_09365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5201"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15489" checksum="D9909DB7B767D668" modified="2015-06-24" version="1">MNLEDLVRLRRARDAMDRDYAKPLDVPALARIALMSVGHFQRSFRAAYGETPYGYLMTRRIERAKALLRRGDLSVTEVCFEVGCTSLGSFSSRFTELVGESPSAYRARDHGDSAAIPACIAKIHTRPVRNGEAKPDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNJ0</accession>
    <name>A0A0F4JNJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
            <shortName evidence="8">DHK-MTPene dioxygenase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="8">ARD'</shortName>
            <shortName evidence="8">Fe-ARD</shortName>
            <ecNumber evidence="8">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="8">ARD</shortName>
            <shortName evidence="8">Ni-ARD</shortName>
            <ecNumber evidence="8">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtnD</name>
        <name evidence="9" type="ORF">VR44_08900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) cation per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="8"/>
    <dbReference type="EC" id="1.13.11.53" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946858.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35917">
        <property type="protein sequence ID" value="KJY35917"/>
        <property type="gene ID" value="VR44_08900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4949"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01682">
        <property type="entry name" value="Salvage_MtnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023956">
        <property type="entry name" value="ARD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in metal incorporation in vivo" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in transmitting local conformational changes" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="site" description="Important to generate the dianion" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY35917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="22417" checksum="2EE4702048FBA751" modified="2015-06-24" version="1">MTLLTTWPESGPETVVRRTSEPGEIAAALAPLGVRYEQWPVRDDVPADADSDTVLTAYRAEIDRLTAAEGFATVDVVALHPSDDPGFAGKAKAAREKFLEEHTHDDDDEVRFFVAGSGIFYLHVDGEVHAVLCERGDLLGVPRGTTHWFDMGTRPAFTAIRFFHEEDGWIGSFTGSGISRRFPDFDTIAAQYAEYAEYAEYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP98</accession>
    <name>A0A0F4JP98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946842.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36000">
        <property type="protein sequence ID" value="KJY36000"/>
        <property type="gene ID" value="VR44_08815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5009"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="23220" checksum="F9C8B7BA4CF85160" modified="2015-06-24" version="1">MSASRYTVSDVMTHTAVAIGREASYKEIVELMHQWKVSALPVLEGEGRVVGVVSEADLLPKEEFRRTEPVLPDQLEEASKAGGTLAEELMSSPAVTVHPDAPVAEAARIMAHKRVKRLPVVNEVGMLEGVVSRSDLLKVFLRPDEELEEEIRLSVLTELMPGAALDFAVQDGVVTLRGRLPDRALVPLVARAIRAVEGVVDVRMELDSAVGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPP3</accession>
    <name>A0A0F4JPP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_09115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="JZWV01000197">
        <property type="protein sequence ID" value="KJY35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946896.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5120"/>
    <dbReference type="EnsemblBacteria" id="KJY35814">
        <property type="protein sequence ID" value="KJY35814"/>
        <property type="gene ID" value="VR44_09115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5087"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470927" description="Cytochrome bc1 complex cytochrome c subunit" evidence="13">
        <location>
            <begin position="41"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="28543" checksum="937D032DAE1A573C" modified="2015-06-24" version="1">MKKLSARRRHPLAAVVVLLFALAVTGGLYAAFAPAGKAQADETAQSLAIEEGKKLYAVGCASCHGTGGQGSSDGPSLVGVGSAAVDFQVSTGRMPAQQPGAQVPKKRNIYSQAQIDQLAAYIASLGAGPITPTEKQYDPAGADIAAGGELFRNNCAQCHNFTGEGGALTNGKYAPNLEGVEPKHIYEAMLTGPQNMPSFPDSTMPEKQKKDIIAYLQNVNGEKSVSPGGLKLGGLGPVSEGLFGWIFGLGALIAVAVWVAAHTAVWVAAHTAKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRF1</accession>
    <name>A0A0F4JRF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947075.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3225"/>
    <dbReference type="EnsemblBacteria" id="KJY35501">
        <property type="protein sequence ID" value="KJY35501"/>
        <property type="gene ID" value="VR44_10065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5612"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="148"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="35201" checksum="50A625028E45B948" modified="2015-06-24" version="1">MAANAIDQTRRMLSLVTYLRERPGAHVADVARAFGITEDELISDLDVLPMCGTSFRGGDLLDIDTDGDRIWWHNADASGESTAEPLRLAADEATSLLVAARAVATLPGLRESDRDALLRATAKLEAAAGEAAGASSRLSVTFESEGGVFADVDRAISERRRLWLRYYSPARDELTERTVDPIRLFAVGHTYLEGWCHLSEARRTFRLDRVAEIRLLDERAEPPAIEPRDLSEGLVQPAAEDPEVVVEVGPGGRWVAEYYPHDSAEELPDGGLRIVLRSPDPASLRRLALRLGRDGRIVSPPELAQSARRAATEALAGYGEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRX6</accession>
    <name>A0A0F4JRX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946939.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35706">
        <property type="protein sequence ID" value="KJY35706"/>
        <property type="gene ID" value="VR44_09340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="31609" checksum="B795B38526094AA5" modified="2015-06-24" version="1">MPPRTSPTERQKRLGAELRKMRVAADVSAESAAGLLGLDRSKVSAIEQGIRAISEERLRALACHCDCADEEYINALVAMTQTRKRGWWERYRGSLSAAILDIAELESHATRMLCAHSVHIPGLLQTSEHAMALFRFAVPTLPEEQVTMRVAHRLERQRVIEGDSAPEYVAVVHEAALRMQFGGPKVARAQLEYLGHMSERDNIILRVLTFDAGGFPGAGQTVNYLEGPVPQLDTVQVDSTHGPDFLHTEAQLAKYRQQLEWMERLSLPPAESRDFIHALARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS42</accession>
    <name>A0A0F4JS42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_07635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946619.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36573">
        <property type="protein sequence ID" value="KJY36573"/>
        <property type="gene ID" value="VR44_07635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4139"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24420" checksum="5B11790F9F39948B" modified="2015-06-24" version="1">MYQLTGVTKRYQRGKQTVDALAGVDLTIEDGGRLVIQGPTGGGKSTLLQMLGGLDRPTAGQVVLDGVDLGAISEARLTKVRAESIGFVFQSFNLIPTLTAQENVETALVPLGLKTAERRARAAEALESVGLGERTGHLPAELSGGQQQRVAIARALVKKPKVLLADEPTGNLDESTRDEVMDLLEGLWKDHGLTFVMVTHDSALAKRAPRVATIERGRVTVTENLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSD5</accession>
    <name>A0A0F4JSD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone GroES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946337.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5799"/>
    <dbReference type="EnsemblBacteria" id="KJY37282">
        <property type="protein sequence ID" value="KJY37282"/>
        <property type="gene ID" value="VR44_06120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2560"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="33943" checksum="8401C139DC57E9DC" modified="2015-06-24" version="1">MFAAYAARIDRDQPLNGLELGERPAPEARPGWVTVNVKAASLNHHDLWSLRGVGLDADKLPMILGCDAAGTDQDGNEVVLHSVIGQSGHGVGPDEPRSVLTELYQGTFAEQVSVPAWNVLRKPAELSFAEAACMPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGRAAGLRVYATSRDEAKRKRAVELGAIEAFPPGARLPHRVDAVIETVGAATWSHSVKCLRPGGTLVISGATSGDTPAQGELRRIFFLELKVVGSTMGTKDELEDLLAFCATTGVRPVIDEVLPLDRAREGFERLESGDLFGKIVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT34</accession>
    <name>A0A0F4JT34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_08520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946786.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36126">
        <property type="protein sequence ID" value="KJY36126"/>
        <property type="gene ID" value="VR44_08520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4767"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="135"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="646" mass="68716" checksum="CA0C19008469FA3F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTD2</accession>
    <name>A0A0F4JTD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946734.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36236">
        <property type="protein sequence ID" value="KJY36236"/>
        <property type="gene ID" value="VR44_08250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4548"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="38655" checksum="681ADB3C8486D20D" modified="2015-06-24" version="1">MTNEGQPIEPGHIYTRAEIRRVFGGSPYGGICPSTTSPSVVLYSDPSVGEAFGYHDGWLGEADAGGPIFEYTGAGLSGDQGFAGAGGAGNAAVLRHEQSGRALHLFVRHGKVEGTSTKTHRYVGRFTLDSVQPFVPRQGKGADGQLRTAIVFRLRPIDSVEPSPADDLEPAPSTSAEFVPRAITVEMLQAAAVTRTVLTTHSMGSMSGQSLAAAARGKLVGVEAFKTPKATRSAVPETVILRNEALLVDRYVAHLEARNHVIGAFQIRVKGATSTLRTDLYDATDHVLYEAKGSVSRINARMAMGQLLDYRRHVRTEQHPYPPKCAILLPEAPDEDIANYFLSHDISIVHAVNGGGFVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTF2</accession>
    <name>A0A0F4JTF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH crp-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946431.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37109">
        <property type="protein sequence ID" value="KJY37109"/>
        <property type="gene ID" value="VR44_06595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3236"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="12067" checksum="85EF4113585A9D07" modified="2015-06-24" version="1">MSRYTKYSVDYLNSVNRGRVRYDLTANAYRLLFLLTSTQTPGAPGVALTGSQEAIAEVLGCSQPTVSKCLKQLREAGVIKPLDGGRWQIHADYMLGGYRAGEKVVAMPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTN6</accession>
    <name>A0A0F4JTN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946430.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37108">
        <property type="protein sequence ID" value="KJY37108"/>
        <property type="gene ID" value="VR44_06590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3235"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15133" checksum="D1290DC76B95F24C" modified="2015-06-24" version="1">MTTSSIPAGSRPAVDPVRAEALLLAAGDPEEPKLETDAEGRVLIPHAPLWRPGVHLHEYVAIWPASTTPRTRSHRHGRLLAHVRVLDGGGKVRDLGLRRLELVHWILGLSTAIGAGWVVGRVTPMLGHGAQLSGIPRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX9</accession>
    <name>A0A0F4JTX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000162">
        <property type="protein sequence ID" value="KJY36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36416">
        <property type="protein sequence ID" value="KJY36416"/>
        <property type="gene ID" value="VR44_08100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4447"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="47542" checksum="9FFF67F8B10E21AC" modified="2015-06-24" version="1">MPENRSDPASRWIRLGVAIVPALAAKPRPDPIVWLAGGPGDDAVGEAKLAVDGGLNRDRDVILMSQRGTYSANPALTCPNIDEFNARATGLASDSPETQRLHLQATKACRDRLAGLGADLGAYNDIESSADLADLRTALGLPQWNLYGISYGTQLALVTMRLHPQGIRSVGIDGILPPSTAGEALAWSAAKQGFDGLFKACAEQPACNDRYPNLSATFERLVGELQAKPVTTTITLPGTHKQVKVVLDGTALVNWMTSATHVAPQVPRALDELAHGKPQRIAEQWAAAKYSPQAVGRTSHGLVYGVFCSEWTPYEARDAAVRGGEEAFPSFPRSVRSQSPQLAYLHQDCDTWNVPAAPRSIRDATKGDIPTLAISGGFDSQTGAANGPYVARTLNRATVVTVPYEPHVVLATSKCARTIVASFFDTPTAPDTSCLKGLKAPAFETGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU10</accession>
    <name>A0A0F4JU10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the melC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946096.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37852">
        <property type="protein sequence ID" value="KJY37852"/>
        <property type="gene ID" value="VR44_04820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1045"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023199">
        <property type="entry name" value="GriE/MELC1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010928">
        <property type="entry name" value="MelC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06236">
        <property type="entry name" value="MelC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471358" evidence="4">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14146" checksum="65D5A1ACEE89AF01" modified="2015-06-24" version="1">MNMITRRQALGLGSGVAAAIGLAACSSKPSSAPAAGASGAPGAAGPSGAPVALPTGTIDETYQGHRIQITVGTGGHHGVGMPVVKIDGNELHIMRNADNSWVTVVNHYETFPDPISAARAAVRELQGADLVPFTPKEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUM7</accession>
    <name>A0A0F4JUM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946006.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4225"/>
    <dbReference type="EnsemblBacteria" id="KJY38062">
        <property type="protein sequence ID" value="KJY38062"/>
        <property type="gene ID" value="VR44_04290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="458" mass="50406" checksum="F1594D01B06465F0" modified="2015-06-24" version="1" fragment="single">MADDYLVRIGKLIRDARQHRGWTQTQLAEALGTSQSAVNRIERGNQNISLEMIARIGEALDSEIVSLGYAGPMHLRVVGGRRLSGAIDVKTSKNACVALLCASLLNKGRTVLRRVARIEEVYRLLEVLNSIGVRTRWINDGVDLELIPPAVLDMDAIDAEAAVRTRSIIMFLGPLLHRMDHFRLPYAGGCDLGTRTIEPHMIALRRFGLDITATEGIYHAKVEPGVSPGRPIVLTERGDTVTENALLAAARHDGVTVIRNASSNYMVQDLCFFLEALGVKVEGIGTTTLTVHGVPVIDADVDYSPSEDPVEAMSLLAAAVVTESELTIRRVPIEFMEIELAVLEEMGLDHDRSAEYVADNGRTRLVDLTVRPSKLEAPIDKIHPMPFPGLNIDNVPFFAAIAAVAQGQTLIHDWVYDNRAIYLTDLNRLGGRLQLLDPHRVLVEGPTRWRAAEMMCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUS0</accession>
    <name>A0A0F4JUS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000143">
        <property type="protein sequence ID" value="KJY36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2231"/>
    <dbReference type="EnsemblBacteria" id="KJY36731">
        <property type="protein sequence ID" value="KJY36731"/>
        <property type="gene ID" value="VR44_07310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3933"/>
    <dbReference type="eggNOG" id="COG5653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15087" checksum="9144926322E9EA84" modified="2015-06-24" version="1" fragment="single">VRAGEGRLTEFRLDGKVVAANVTLLSAALSGGYLYGADPDLRERKVDVATLLLRYEAGRALEEGRPVVSFLRGNEPYKNHWRPETVVNQRLLLATHALAPLMRLHESQVTGRERAVGALREALPAAREALPPPGTGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUX0</accession>
    <name>A0A0F4JUX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000101">
        <property type="protein sequence ID" value="KJY37538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946221.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37538">
        <property type="protein sequence ID" value="KJY37538"/>
        <property type="gene ID" value="VR44_05480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1733"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471256" evidence="1">
        <location>
            <begin position="30"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="31063" checksum="0D81FB7D77DCFC59" modified="2015-06-24" version="1">MGIKRGTTLAAVAVVVVLAATACNGDDKADKADAAKPAGATAAAPAADPYAGGGGAGAAAAKPAGALAVSTTDKLGPVLTDSAGFTLYRFDKDTAKPPASNCDGDCAKAWPVVPAGDASAAAGMDPSLLGEVVRKDGSKQLTVAGWPAYRFAKDTKAGDLGGQGVGGTWFALAPDGKKAAKAAAPAPAGTPGQAAGALTVAKDPALGEHIVDGNGMTVYRFKPDTAWPMVSKCTGDCLAKWPVVPPAERGSGIVEKNYLVLDRPDGKKQQTVNCWPVYTFTGDKKPGDVNGQGVGGTWYAVAPDGKLIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW32</accession>
    <name>A0A0F4JW32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_06270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946368.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37191">
        <property type="protein sequence ID" value="KJY37191"/>
        <property type="gene ID" value="VR44_06270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3008"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9911" checksum="70E4AE09838A8162" modified="2015-06-24" version="1">MSWLWAIIVGFVLGLIARAILPGKQNQPLWLTTVFGIIGGVLGNAVATWIGVHDTRGIDWTRHLLQLAGAVAIVALGEMVYLALRGGKRHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWF3</accession>
    <name>A0A0F4JWF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818391.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4236"/>
    <dbReference type="EnsemblBacteria" id="KJY38068">
        <property type="protein sequence ID" value="KJY38068"/>
        <property type="gene ID" value="VR44_04330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.433"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27992" checksum="7E234213C519FCE3" modified="2015-06-24" version="1">MVHVSAAPVLALRGVSKRFGAVQALTDVELEIHSGEVVALVGDNGAGKSTLVKTIAGVHPIDDGVIEWEGRPVSIGKPHDAQNLGIATVYQDLALCDNIDVVGNLFLGRELKRYGVLDEVEMERRARELLTTLSIRIPSVRIPIASLSGGQRQTVAIARSMLGEPKLVILDEPTAALGVEQTAQVLDLVERLRERGHAVILISHNMADVKAVADKVAVLRLGRNNGVFNVADTSQEEIISAITGATDNAVTRRAARTGEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXL4</accession>
    <name>A0A0F4JXL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945829.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6598"/>
    <dbReference type="EnsemblBacteria" id="KJY38569">
        <property type="protein sequence ID" value="KJY38569"/>
        <property type="gene ID" value="VR44_03290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7874"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="29492" checksum="572F470168DD0C9D" modified="2015-06-24" version="1">MTDAAALPGQPRGTVVSGPATARAINVLAPNPSAMTLDGTNTWLVSEPDSDLAVVIDPGPLDEAHLRAVIATAEQAGKRIALTLLTHGHPDHAEGAGRFAELTGTKVRALDPALRLGDEGLAAGNVIRTGGLELRVVATPGHTSDSLCFHLPADRAVLTGDTILGRGTTVVAHPDGRLGDYLDSLRRLRSLTVDDGVHTVLPGHGPVLEDAQGAVEYYLAHRAHRLAQVETAVDDGLVTPEAVVAHVYADVDRSLWPAAEWSVRAQLEYLRDHGLIPGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXZ0</accession>
    <name>A0A0F4JXZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945806.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6555"/>
    <dbReference type="EnsemblBacteria" id="KJY38603">
        <property type="protein sequence ID" value="KJY38603"/>
        <property type="gene ID" value="VR44_03165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7848"/>
    <dbReference type="eggNOG" id="ENOG5032PQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="22849" checksum="AB5BBA3C142645DC" modified="2015-06-24" version="1">MACDLWLVPLVDVLCHSPDNPFAEEIAAYDKALGEAGLPSVPVFAYMPGLSGDVAPVAGFDYDALHFLRRAYLLQICGLPVTPVDELGGDYEQLLEMFESTAQQSHLVWHYDHAGAYVPVDFPAPLANEELLAGGGPLGSAQGLLRELAFVAPAIGIDPMNPPAPPAPPGGPTALEEPAGPIPYDASPFARERHVWLGLHAAATRSLGQGSMIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY36</accession>
    <name>A0A0F4JY36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38648">
        <property type="protein sequence ID" value="KJY38648"/>
        <property type="gene ID" value="VR44_03120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7839"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="214"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="46274" checksum="A1A7F98B65E67459" modified="2015-06-24" version="1">MASPEQDGLGVRGVARQLFTLRRDPLPPMRRPRWLARLPHGLIVYAAVFFGFMTSAQLQDHYRVHDPRIVVLSLFTGFSIVAAMFRPIAAWWLGLVTAGFVAATIHGDVGQGQSWPWTPLGPFAFAPLVLLVALRVPPKVTAAVIGVSVACTGVAEALFRPERSQSSAIGALLVFGFAGLLGYALRATRLARSQLVAQESLTEEERARRTLLEERSRIARELHDVVAHHMSVISIQAQVAPHLVENPSEELKENLAGIRENALEALTELRRVLGVLRSEQAGDPADPHHPQPTLAELDGLVDNVRGAGLEVTQEVAGIRRPLTPGVELTAYRIVQEALSNCLRHAPGSRVEVGIAYGPRDLHLCIANSAPTRPAPPSPGAGHGLLGMRERAGMLGGELAAGPRPDGGYEVSAVLPMDPPGRSSYETKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYC5</accession>
    <name>A0A0F4JYC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38849">
        <property type="protein sequence ID" value="KJY38849"/>
        <property type="gene ID" value="VR44_02740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6789"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="30009" checksum="E3685831295F01AE" modified="2015-06-24" version="1">MIMVLVTAELAGAPCWISLTARDVAASESFYNAVLGWTFRRGSLGRAFSVAEADGVPVAGIAAVARELAVPVAWTPYFAVDDADDAVARIRERGGTVGVGPVAYPPRGRAALAVDREGAAFGIWEGRVLTEWRVGDGTAPAWLELHTADALDAALFYGETLQWASDGGTGCCEVSYEHDQVVLRYDGEDVARLNSGPVEEAAEKPQLRPRWLVHFRVRDLEAATEAAVEHGGTVVQEGAWPTRTRQVTVRDPDGALFTLDPSRTAPWPIRPDAQPSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYV8</accession>
    <name>A0A0F4JYV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945687.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39009">
        <property type="protein sequence ID" value="KJY39009"/>
        <property type="gene ID" value="VR44_02500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="154"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32111" checksum="B2C419AA76DE7F61" modified="2015-06-24" version="1">MMGPMAPVVVGVDGSDASLSAVDWAADEAARLSLPLRIVYASLWEHYEGAVPAWTLDRPSGQVLAENIVAAGAERVRQRRPGVPVTTDIVAEDAASALLREGHMADVVVVGSRGRGELADLLLGSAALVVAARSSGPVIVVRGDRQALEGRHGRVLLGIGPHDVDSPAVRFAFREAAARDAELDVVCTWRRQLHEPADHMAVSGDVPRDREQRAAALVDKAVEAVSRDHPQVLLRRTTLEGTARKVLTERSAAADILVVGARRPGSLVGMELGRVAHRALHHAHCPVAVVPQHHDAPVPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ65</accession>
    <name>A0A0F4JZ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000031">
        <property type="protein sequence ID" value="KJY39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39114">
        <property type="protein sequence ID" value="KJY39114"/>
        <property type="gene ID" value="VR44_02180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5700"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14499" checksum="54AC91AB41DBD3C5" modified="2015-06-24" version="1" fragment="single">YLNRPEATAEVLVDGWLRTGDIGVREEDGYLRVLDRKKDVVIRGGYNVYPREVEEVLLGHPSVAQAAVVGVPDERLGEEVCAVLRTAPGVRPDPGLAEEIAVWSGERLARYKYPRRIVFTEAFPVGPTGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0F9</accession>
    <name>A0A0F4K0F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945766.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38736">
        <property type="protein sequence ID" value="KJY38736"/>
        <property type="gene ID" value="VR44_02990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7330"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24645" checksum="9DA715DEF30F5A8F" modified="2015-06-24" version="1">MTDERPARAAGLRERKKRRTRDALLRAALLLFISQGYENTTVDEITETVEVSQRTFFRYFANKEEVAFAVQDLVESHFVAALGARPAGEPPLAAMRGAVLAAWDTLDEALSEVVPVDLYMQAYRLIESTPALLAVHLRRSTELEERIARLVAEREGLDLDADPRPRIAVAAFCGVMRVTGRLWGQGEDVSVTAIRRMTEAYLDQIGPALASDWHRPAPVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0I5</accession>
    <name>A0A0F4K0I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945403.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39624">
        <property type="protein sequence ID" value="KJY39624"/>
        <property type="gene ID" value="VR44_01020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2917"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23637" checksum="FA52F56F74CB591D" modified="2015-06-24" version="1">MTLLHLFDLDGTLMYGSAAPVEISRQLGLEVEIAELERAFGAREIGPQEFSTAAREMWAELTPAHVRAAFDGAPWLIGIRDVWQEIRERGDYCAVISLSPSFFVELLLEWGAHAAHGSVFPEVPFTRPVDVTGILTPEGKLTVADRLCERFGVTRADCVAYGDSMTDAVLFGALPRSVAVNARPHLVERATHVYEGRDLREAYQLLGGTRPGVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0J8</accession>
    <name>A0A0F4K0J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_01120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945418.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39639">
        <property type="protein sequence ID" value="KJY39639"/>
        <property type="gene ID" value="VR44_01120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2938"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="335"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="616"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="732" mass="76911" checksum="91B295FEE76831A1" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0R4</accession>
    <name>A0A0F4K0R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945728.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38851">
        <property type="protein sequence ID" value="KJY38851"/>
        <property type="gene ID" value="VR44_02755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6792"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035223">
        <property type="entry name" value="DUF5335"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17269">
        <property type="entry name" value="DUF5335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13358" checksum="8709CEFEB2FD9E4C" modified="2015-06-24" version="1">MPGNASLDRSDWTSTLDEATATHEGELITIEVMDQSIGHQYEAERLPFSYLSYDHKSDAVVVAVGGRPPRYPVVLRHIVAHPKEIDVSTVDVPETAIRVLDQDDTATLITFYPAGPAGPAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0V5</accession>
    <name>A0A0F4K0V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_01355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4676"/>
    <dbReference type="EnsemblBacteria" id="KJY39558">
        <property type="protein sequence ID" value="KJY39558"/>
        <property type="gene ID" value="VR44_01355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2987"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="20007" checksum="98CF7DA3D4FD3C0A" modified="2015-06-24" version="1">MTTPVCTLASNPTPYPSFSAYVRTRGTALMRTARSLTANPCDAEDLLQTALAKTYVAWDRIEDHRALDGYVRRALVNTRTSQWRKRKVDEFVCEEVPETEEQSCADPAETQVLRDAMWRAVTRLPDRQRAMVVLRYYEDLSEAQTAELLGVSVGTVKSAVSRALVKLREDPELTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K143</accession>
    <name>A0A0F4K143_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000041">
        <property type="protein sequence ID" value="KJY38946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945703.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38946">
        <property type="protein sequence ID" value="KJY38946"/>
        <property type="gene ID" value="VR44_02615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6829"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="518" mass="54966" checksum="E1458599E06B3169" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1E4</accession>
    <name>A0A0F4K1E4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitosanase</fullName>
            <ecNumber evidence="1">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39041">
        <property type="protein sequence ID" value="KJY39041"/>
        <property type="gene ID" value="VR44_02325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6755"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00978">
        <property type="entry name" value="chitosanase_GH46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.386.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000400">
        <property type="entry name" value="Glyco_hydro_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023099">
        <property type="entry name" value="Glyco_hydro_46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01374">
        <property type="entry name" value="Glyco_hydro_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036551">
        <property type="entry name" value="Chitosanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60000">
        <property type="entry name" value="CHITOSANASE_46_80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036551-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="31998" checksum="4F95403346B224F0" modified="2015-06-24" version="1">MVGKFPNGTGKAQPPYGGLVFTTPRAVMAVGALLGATLLAVPAAAQAVPAAPTPQAARARAAAGLDDPAKKDIAMRIVSSAENSSLDWKAQYKYIEDIGDGRGYTAGIIGFCSGTGDMLDLVEYYTQVKPGNVLAKYLPALRRVNGSDSHSGLDPNFTRDWAKAAQDAEFKKAQDHERDRVYFDPAVKQGKSDGVGTLGQFIYYDAIVMHGDGGDATSFRSIRKRALAKAKPPAQGGNETTWLNAFLDARVWAMKQEEAHSDTSRVDTAQRVFLRKGNLNLNTPLDWKVYGDSYHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3D3</accession>
    <name>A0A0F4I3D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001747">
        <property type="protein sequence ID" value="KJY16500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16500">
        <property type="protein sequence ID" value="KJY16500"/>
        <property type="gene ID" value="VR44_40435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20706" checksum="D84C98201FAF5E6E" modified="2015-06-24" version="1" fragment="single">ETWYWKATDAGHTDAMTNLGLLLANIGRTNEAETWYRKAADAGQIDAMHNLGLLLANIGRTNEAETWYRKAIDAGHTDAMYSLGLLLANTGRTNEAETWYRKATDTGQINAMHGLGLLLANTGRTNEAETWYRKATDGGSSGAMNNLALLLQNTGRETEAQPWYERAANAGDANAMNNLGALLQNTGRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I731</accession>
    <name>A0A0F4I731_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001666">
        <property type="protein sequence ID" value="KJY17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17469">
        <property type="protein sequence ID" value="KJY17469"/>
        <property type="gene ID" value="VR44_39950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10175" checksum="A6B8D8FCF50BE901" modified="2015-06-24" version="1" fragment="single">TVDTACSSSLVALHLAAQALRRGECDLALAGGVTVMSSPNAFIEFSRQRGLAADGRCKPFAAAADGTGWGEGVGMLLVERLSDARRHGHPVLALVRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I969</accession>
    <name>A0A0F4I969_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001618">
        <property type="protein sequence ID" value="KJY18199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18199">
        <property type="protein sequence ID" value="KJY18199"/>
        <property type="gene ID" value="VR44_39660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6049"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY18199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="573" mass="58822" checksum="1E0A59A145948BC4" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IC99</accession>
    <name>A0A0F4IC99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001545">
        <property type="protein sequence ID" value="KJY19632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001545.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19632">
        <property type="protein sequence ID" value="KJY19632"/>
        <property type="gene ID" value="VR44_39045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5570"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12838" checksum="DAB107E50433E8A5" modified="2015-06-24" version="1">MTSTPACPRCGQTPLTALRVEYTRNRWGGSGPTPRPEEWWECSGCGWVGYRDTGTGPLTPMRRPEGGEADCFFCGEEGGNVVSEPWRREDGELRDWVVCLSCGTSNQRRVRGLPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJP8</accession>
    <name>A0A0F4IJP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001428">
        <property type="protein sequence ID" value="KJY22222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5665"/>
    <dbReference type="EnsemblBacteria" id="KJY22222">
        <property type="protein sequence ID" value="KJY22222"/>
        <property type="gene ID" value="VR44_37995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5165"/>
    <dbReference type="eggNOG" id="COG3115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="8984" checksum="7FA4FCFC0C250B73" modified="2015-06-24" version="1" fragment="single">MTSNPSTPDTDGPKTETTLTTRIRINIPGSRPIPPVVVRKPVKDAAPEAAAPGAAESEPAPAPRGQAPAPVRAALPARPTAQAPAPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IN88</accession>
    <name>A0A0F4IN88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein terZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001393">
        <property type="protein sequence ID" value="KJY23487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952167.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001393.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5328"/>
    <dbReference type="EnsemblBacteria" id="KJY23487">
        <property type="protein sequence ID" value="KJY23487"/>
        <property type="gene ID" value="VR44_37620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5029"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15633" checksum="2AD5B6A8A48B14CB" modified="2015-06-24" version="1" fragment="single">LDASAVLFADKQPVDVVFFRHLQSDDGSVRHTGDNLVGGVGQGGDDEAILVDLQRVPVHIDTIVFTVNSFTGQTFQEVQNAFCRIVDETNGQELARYTLDGGGQYTAQIMAKVSRTGGGWQMTALGTPANGRTFQDLMPAILPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INS5</accession>
    <name>A0A0F4INS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001389">
        <property type="protein sequence ID" value="KJY23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23677">
        <property type="protein sequence ID" value="KJY23677"/>
        <property type="gene ID" value="VR44_37585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="19483" checksum="CCF9DCC146862905" modified="2015-06-24" version="1" fragment="single">PAALVGARLGRPVDQACARACHEATGGHPLLLTATLDALTAAGPQAHGGRLPDARDIRGIRPDALRERLAVALRGQRPPVWRLAAALAVLGGDPGHAEAPGDTESAGEDPAARLAGLDATGRAEAVRVLRRLGLLAEGPVPRFVHPVVADAVEETLAPAEARDLRLRAALLLHQGGHPAERAADQLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPW5</accession>
    <name>A0A0F4IPW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001305">
        <property type="protein sequence ID" value="KJY24042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24042">
        <property type="protein sequence ID" value="KJY24042"/>
        <property type="gene ID" value="VR44_36480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4597"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27941" checksum="5D4537E42D9A9341" modified="2015-06-24" version="1" fragment="single">YDDLLARHERTTQALATAEDELRTQRQHHQEETLRLNTLLQEQQDAHLRDCTAFEARLGRARADHEDQLRAREEEEARLRRDLLAQEDKIRSFRGLLEDSAAEASALRQERDRLRVESARLREDLVGLQVELAAAEAGRDNPAGDGMLAPALLAVGQVLDRHPAPQESSEAAGRLRVARGATRHSNPVTPSVADHPEPGSTPKADRLKRPSAGFVAVGMVLLLTGPFLHTGGPMADSRPTAAGWWCMPPPSSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQX9</accession>
    <name>A0A0F4IQX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001231">
        <property type="protein sequence ID" value="KJY24412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951757.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001231.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24412">
        <property type="protein sequence ID" value="KJY24412"/>
        <property type="gene ID" value="VR44_35420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="28293" checksum="23C95470F0947B9B" modified="2015-06-24" version="1" fragment="single">MSSTELPGVRSTAEPTSQVGAVRVAEGEGLRTVALPGLEMNVRFRPPQREGLPPALFVHGLGGSSQNWSALMEQLADSVDGEAVDLPGFGWSPPPADRDYSVTGLARAVIRHLDAAGRGPVHLFGNSLGGAVSTRIAAVRPDLVRTLTLVSPALPELRVQSSAVPTALLALPGVPALFGRLTRHLTAEQRTRGVTDLCYGDPSRVTPEGFANAVEEMERRMALPYFWEAMSRSSRGIVDAYTLGGQHGLWRQAQRVLAPTLLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR89</accession>
    <name>A0A0F4IR89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001272">
        <property type="protein sequence ID" value="KJY24189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951883.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001272.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24189">
        <property type="protein sequence ID" value="KJY24189"/>
        <property type="gene ID" value="VR44_36085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4457"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="30903" checksum="8FB378F2FEFA8D56" modified="2015-06-24" version="1">MTDKTMTPDEVVGRLRSGMTLGIGGWGSRRKPMALVRALLRSEITDLTVISYGGPDVGLLAAAGRVRRLIAPFATLDSVPLEPHFRAAREGGSLALTEYDEAMFMWGLHAAANRLPFLPVRAGLGSDVMRVNPELRTVTSPYADGEEFVAVPALRMDAALVHLNRADRLGNAQYLGPDPYFDDLFCEAADSAYVSCEQLVESAELAKSGPPQSLLVSRHSVTGVVETPNGAHFTSCAPDYERDEAFQKLYATTPWPEFAARFLSGAGEHDYQSAVRTWQEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK9</accession>
    <name>A0A0F4IRK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001251">
        <property type="protein sequence ID" value="KJY24304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951814.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001251.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24304">
        <property type="protein sequence ID" value="KJY24304"/>
        <property type="gene ID" value="VR44_35735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26072" checksum="C226C30192809954" modified="2015-06-24" version="1">MYEEAPSRTVPGAVVWRARGQGGAVLPDGCMDLLWTGGRLLVAGPDTGPHPAGEVPGRSFTGLRLAPGAAPALLGVPAWELRDRRVELAALWPGPEVRRLTERTAGYEDPRAGLEALARARFAAVGPPDPLPAEVTARLRAGQPVSAIAAAVGLGERQLRRRCLDAFGYGPRTLGRVLRLQRALALTRRGLPQAEVAYAAGYADQAHLAREVRALAGTTLGAWAAAQAPSATSGANSETWQPSGSRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRM6</accession>
    <name>A0A0F4IRM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001185">
        <property type="protein sequence ID" value="KJY24670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24670">
        <property type="protein sequence ID" value="KJY24670"/>
        <property type="gene ID" value="VR44_34650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3915"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="34053" checksum="1D40536A983482A8" modified="2015-06-24" version="1">MTFGIYPGGLLGDEQGIVHPVSPDDPERINAALDALQGDADTLSVRAYRSFATTVTPYGPTPADPQACLRRGRTLDLVLQFREPSGRLDGWPDFVRGAVRDGGPGLASVQICEEPNLNLPPVDGSTPNVLNALVQGVVAAKEEARSLGRRVAVGFNAVPSFDPADTFWSDLGNLAGPGFVQSLDYVGLDFFPDVFRPVAPGRLADAVTAVLTSYRRTCLPKAGIPDTIPVRICENGWPTGPGRTEQHQAAALDTVIRTTAALAAELNIEGYSLFALRDADSHAEGIFSHFGLLHDDYTPKQAFETYRRLIAELGGEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS09</accession>
    <name>A0A0F4IS09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001229">
        <property type="protein sequence ID" value="KJY24429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951753.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001229.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24429">
        <property type="protein sequence ID" value="KJY24429"/>
        <property type="gene ID" value="VR44_35405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4195"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="31527" checksum="6F49627EB57E5D88" modified="2015-06-24" version="1">MKAITYSSYGTPTALELVDVPEPKVGPGEVLVRVRAAGVNPVDWKLAAGFLGHVLEVRHPVIPGWDVAGVVEAVGPDTDDYAVGDEVYGYVRKEWVQLGTYAELVSAPVRTLARKPATLTFEEAAGLPLAGLTSYQAVTRAGVSAGQTVVIHSAAGGVGSLGVQIAVALGARVIGTASARNHDYLRSLGAEPVLYGDGVAERVAALAPEGVDVGLDFYGEGGVELLQSIVRPGGPVISVADNDAGDKGAKHIWARSSATDLTTLAELADTGRITVKVGHVLPLAEAGRAWELSAAGQARGKIVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS69</accession>
    <name>A0A0F4IS69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001248">
        <property type="protein sequence ID" value="KJY24328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951805.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001248.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3790"/>
    <dbReference type="EnsemblBacteria" id="KJY24328">
        <property type="protein sequence ID" value="KJY24328"/>
        <property type="gene ID" value="VR44_35685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4288"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="6">
        <location>
            <begin position="43"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="35442" checksum="F3A5D78974CBA72C" modified="2015-06-24" version="1">MTTAAHLHTESGSDAPYALSHLDALESEAVHIFREVAGEFEKPVILFSGGKDSIVMLHLALKAFAPAPVPFALLHVDTGHNFPEVLAYRDRAVEKHGLRLHVASVQEYIDAGKLRERPDGVRNPLQTVPLTEAIQQLKFDAVFGGGRRDEEKARAKERVFSLRDEFSQWDPRRQRPELWQLYNGRHAPGEHVRVFPLSNWTELDVWQYIARENIELPEIYFAHERDVFQRNGMWLTAGEWGGPKDTEPVEKRLVRYRTVGDMSCTGAVDSDAADLDAVIAEIAVSRLTERGATRADDKLSEAAMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IST4</accession>
    <name>A0A0F4IST4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001366">
        <property type="protein sequence ID" value="KJY23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23771">
        <property type="protein sequence ID" value="KJY23771"/>
        <property type="gene ID" value="VR44_37315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4879"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="50" mass="5335" checksum="6309FD6DAD438847" modified="2015-06-24" version="1" fragment="single">MSAMSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSDGFPRDRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISV2</accession>
    <name>A0A0F4ISV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001125">
        <property type="protein sequence ID" value="KJY25072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951416.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001125.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5682"/>
    <dbReference type="EnsemblBacteria" id="KJY25072">
        <property type="protein sequence ID" value="KJY25072"/>
        <property type="gene ID" value="VR44_33540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3590"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="27910" checksum="6D6345DF5DBA3B17" modified="2015-06-24" version="1">MADSVLYEVTDGLAKVTINRPDAMNAMNTEAKVALRDAVQEAAADPAVRAVLLTASGTRAFCVGQDLKEHIGNLAADRESGSKLTMSTVSEHYNPIVRALTEMPKPVVAGVNGVAAGAGFGFALAADFRVVADTASFNTSFAGVALTADSGVSWTLPRLIGASRASDLLLFPRSIKAQEAYELGIVNRLVPADSLHEEAEAVARSLAAGPTVAYAALKESLAYGASHSLSEALEREDVLQTRAGASEDHSIAVQAFLAKQPPQYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISZ8</accession>
    <name>A0A0F4ISZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951371.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4950"/>
    <dbReference type="EnsemblBacteria" id="KJY25130">
        <property type="protein sequence ID" value="KJY25130"/>
        <property type="gene ID" value="VR44_33315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3539"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="16"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="483" mass="51395" checksum="F655F4030C94C4B5" modified="2015-06-24" version="1">MTELVEHGQLFIGGEWTDPLGTGTIRVVSPHTEQVIGSVPHACEADVDRAVAAARKAFEEGPWPRLTLDERIAVVSRIKDAITVRHEEIARSISSQNGSPYSWSVLAQALGAMMVYDAAITVARDYPYEERRQGALGPILVRREPVGVVAAVIPWNVPQFVAAAKLAPALLTGSSVILKPSPEAPLDSFILADIAREAGLPEGVLSVLPADREVSEYLVGHPGIEKVAFTGSVAAGKRVMEVAARNLTRVTLELGGKSAAVILPDADLEAAVAGIVPAAWMNNGQACVAQTRILAPRSRYGEIAEALAAAAGALVVGDPLDPATQLGPLVARRQQQRSLDYIRIGQEEGAKILTGGGRPKGLERGWYVEPTLFGDVDNSMRIAQEEIFGPVVCLIPYTDEAEASRIANDSEFGLSGSVWTADVDHGIDFARGVRTGTFNVNTFSLDMLGPFGGYKNSGVGREFGPEGLSEYLEHKMIHLPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT87</accession>
    <name>A0A0F4IT87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001107">
        <property type="protein sequence ID" value="KJY25212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042811289.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3637"/>
    <dbReference type="EnsemblBacteria" id="KJY25212">
        <property type="protein sequence ID" value="KJY25212"/>
        <property type="gene ID" value="VR44_33105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3493"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="19193" checksum="67D214424B088B7B" modified="2015-06-24" version="1">MQFGRTYEEFEVGAVYKHWPGKTVTEYDDHLFCLLTMNHHPLHMDSNYAENTTDFGKNVVVGNYIYSLLLGMSVPDVSGKAIANLEIESLRHVAPTFHGDTIYGETTVLDKTPSKSKDDRGIVYVETKGYKQDGTLVCVFRRKVMVPTETYIKARGGEQPGRPELKEQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITC2</accession>
    <name>A0A0F4ITC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001177">
        <property type="protein sequence ID" value="KJY24723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951591.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24723">
        <property type="protein sequence ID" value="KJY24723"/>
        <property type="gene ID" value="VR44_34525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3889"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="40"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="40063" checksum="97FD82B20FEE8D07" modified="2015-06-24" version="1">MTQPTPEPEDVFAWIDGAERLREEAGLVRTLRPRPADSPLLDLASNDYLGLSRHPETVRGACAAAERWGAGATGSRLVTGTTELHTELERGLAAFAGFEAALVLSSGYAANLAAVTALSGRGTLVVSDAGNHASIVDGCRLSRAEVEVTPHGDVEQVRKTLAGHGGRALLVTDSVFSVDGDAAPLAAYAAACREAGAALVVDDAHGLGVLGEGGRGALHAAGLAGAPGVVATMTLSKSLGSQGGAVLGPAKVIRHLVNTARAFIFDTGLAPAAAGAALAGLRLLEREPQRADRVREVAAELYGRLTASGLTAVRPDAAVVSVRAPSAAAALRWAADCREEGLSVGCFRPPSVPDGISRLRLTARADLTGDEIGRAVGTVLRTAPAGATEPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITJ1</accession>
    <name>A0A0F4ITJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001168">
        <property type="protein sequence ID" value="KJY24798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001168.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000049_gene3451"/>
    <dbReference type="EnsemblBacteria" id="KJY24798">
        <property type="protein sequence ID" value="KJY24798"/>
        <property type="gene ID" value="VR44_34295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3836"/>
    <dbReference type="eggNOG" id="ENOG50312Q2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470245" evidence="1">
        <location>
            <begin position="35"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="20631" checksum="C7A0FE48EDB9A1A8" modified="2015-06-24" version="1">MEGRVRWRRFALLTVPAVAVTAGLGIALAQGALAASFAVSGQQFKVSAQSLEGEGFAQYGSVDVNARQELIPVAVTAIKEAKLHSLCQSVVTSLPVIGDISLNLTAGKKAPVEASNLFVDATQLAGDAEFTNIEIGRDASTLDKGPAEAQGMQDLFAQQADKVTISSLRQTAWATNAGTFKLSGLSMDISKGKKECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITU9</accession>
    <name>A0A0F4ITU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_32510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001074">
        <property type="protein sequence ID" value="KJY25430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951225.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001074.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7165"/>
    <dbReference type="EnsemblBacteria" id="KJY25430">
        <property type="protein sequence ID" value="KJY25430"/>
        <property type="gene ID" value="VR44_32510"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009470">
        <property type="entry name" value="Chi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06483">
        <property type="entry name" value="ChiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="50"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="703" mass="75116" checksum="CB405E44351AA042" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITY6</accession>
    <name>A0A0F4ITY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Teichoic acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_33910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001145">
        <property type="protein sequence ID" value="KJY24938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951480.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24938">
        <property type="protein sequence ID" value="KJY24938"/>
        <property type="gene ID" value="VR44_33910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3708"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="46"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28605" checksum="3B3CBCF76EC3DF87" modified="2015-06-24" version="1">MADTLTRTATAPGGTAPDTRVPTVIADEVHVVYKVHAGGRKGGATAALSRIFSRKPAPGVREVHAVRGVSFTAYKGEAIGLIGTNGSGKSTLLKAIAGLQPVARGAVYSHGQPSLLGVNAALMNDLTGERNVVLGGLAMGMTKQQIRERYQDIVDFSGINEKGDFISLPMRTYSSGMGARLRFSIAAAKDHDVLMIDEALATGDAAFQRRSQARIEELRARAGTVFLVSHSIGTVRETCDRAIWLESGVVRMDGPSKEVCDAYEAFTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU18</accession>
    <name>A0A0F4IU18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001141">
        <property type="protein sequence ID" value="KJY24968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24968">
        <property type="protein sequence ID" value="KJY24968"/>
        <property type="gene ID" value="VR44_33810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3686"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026325">
        <property type="entry name" value="DUF932"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06067">
        <property type="entry name" value="DUF932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9898" checksum="A06CF0AD88CBA3C1" modified="2015-06-24" version="1">MRRRAGAERGHRETAGGEPRDHRRRLPRARCAAGRPVFLTVKLPQTMTTGRSDKVDLYIAAFNSHDGSSTFRIVGAVTHHPSCFRSAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU69</accession>
    <name>A0A0F4IU69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001058">
        <property type="protein sequence ID" value="KJY25552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951167.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene264"/>
    <dbReference type="EnsemblBacteria" id="KJY25552">
        <property type="protein sequence ID" value="KJY25552"/>
        <property type="gene ID" value="VR44_32210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3163"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="472" mass="51700" checksum="EDB71ED16F86E496" modified="2015-06-24" version="1">MRDPMSALTDAFTSFLFGKVETTRLPVRTSTGQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYIYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVLRQLRFRDRQVVVLDAQGEDGVGEWNLIAEALGITPIRLDPIAANDGGIRLNPLDPAITTTGQLALLRTIIEVAMGHGLDERSGFALKVAHAYVVDTIQDRQPVLTDIVEQLRHPEPESALAMNVDIDDVRAWGLDVALVLDRLVDGDLRGMFDGPTTVGIDLDAPLIVFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAREAAAILKMASTRTIYAQKADEARATGRVLGLPRWAVEIIPTLTPGIAVWDVNGNVQVVKHLITETERPLVYTDRAMTESSTPQQLPEDLLAAELEAEERALYIERQRGAGPGSATTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU74</accession>
    <name>A0A0F4IU74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001057">
        <property type="protein sequence ID" value="KJY25557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951159.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25557">
        <property type="protein sequence ID" value="KJY25557"/>
        <property type="gene ID" value="VR44_32160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9682" checksum="57554A7FA63431FC" modified="2015-06-24" version="1">MSNGKPTSIKTSEATRDRLRLLAQERGTTITELLDELAQSRLTQAEQEQRALEAAAELGLDYTEQLQQAGQSAWDKIRAHQGGAAAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUM5</accession>
    <name>A0A0F4IUM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_33210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001112">
        <property type="protein sequence ID" value="KJY25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951351.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001112.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5334"/>
    <dbReference type="EnsemblBacteria" id="KJY25178">
        <property type="protein sequence ID" value="KJY25178"/>
        <property type="gene ID" value="VR44_33210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3517"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="252"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="635" mass="69172" checksum="27F0CF9C9F48ACF8" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUR2</accession>
    <name>A0A0F4IUR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001027">
        <property type="protein sequence ID" value="KJY25760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951065.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001027.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4583"/>
    <dbReference type="EnsemblBacteria" id="KJY25760">
        <property type="protein sequence ID" value="KJY25760"/>
        <property type="gene ID" value="VR44_31660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3041"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26930" checksum="D62339A7A9DC1A1E" modified="2015-06-24" version="1">MHISDFHGSATALSAESGGRVIAGSTTHGTGRSTPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAEEETARLTEQAKSALGQEEEPWQALSRFLRTSVASGAGRLLPPQVLRVGSAEEDAEDEGAARVPQQRQAVAGGAPELRVVGARTPVEDEPSEDAGAGALLEVVGRLVDRAREAGELRADVTVADVLLVIATAAPALPDPAQQAAASARLLDILLEGLRSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV60</accession>
    <name>A0A0F4IV60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951249.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25373">
        <property type="protein sequence ID" value="KJY25373"/>
        <property type="gene ID" value="VR44_32660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3343"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9876" checksum="F9A9D0CF1C6126FC" modified="2015-06-24" version="1">MDDAWKGWRVYGSEPEDPDPGPEPGHIYVELVGGPLDGQLLDVTGWSPLELADGAVLMSERGAFGPGGRCAYEPTEADGVYPSRFGWRGDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV68</accession>
    <name>A0A0F4IV68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001083">
        <property type="protein sequence ID" value="KJY25383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951242.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25383">
        <property type="protein sequence ID" value="KJY25383"/>
        <property type="gene ID" value="VR44_32610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3310"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469865" evidence="1">
        <location>
            <begin position="43"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="20396" checksum="21610D1B60D0A4B8" modified="2015-06-24" version="1">MGKDGRKPAEGRVDWRKSAAVGLPAIAAVGALAVVMAQGALAASFAVSGTSFQVSSSKLSSKGLASYVHTDRSADGAGHPVALLGIGEATLSDICQSAKVATPLGTVVFKLTAGGPAGEVSAANLVIDGEDLVGDATFGTAQIGRDASTLDQVDGVRGEPGKFGLQAGNIEVAGVRSHAWSATGGDFRLKGMRVGVSLDGATCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVY9</accession>
    <name>A0A0F4IVY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000972">
        <property type="protein sequence ID" value="KJY26200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950884.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000972.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5066"/>
    <dbReference type="EnsemblBacteria" id="KJY26200">
        <property type="protein sequence ID" value="KJY26200"/>
        <property type="gene ID" value="VR44_30675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2590"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13660" checksum="2E831DCDC70BAF39" modified="2015-06-24" version="1">MEIWINPACSKCRSALTLLDAEGAEYTVRRYLEDVPSEAEIREVLGRLGLEPWDITRTSDPLAKETGVRDLPREATDGARARWIAHLAAHPKLIQRPIITAEDGTAVVARSEEAVREALSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWH2</accession>
    <name>A0A0F4IWH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001133">
        <property type="protein sequence ID" value="KJY25016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25016">
        <property type="protein sequence ID" value="KJY25016"/>
        <property type="gene ID" value="VR44_33665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469897" evidence="2">
        <location>
            <begin position="28"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="36247" checksum="3CF97A9B6244FF4B" modified="2015-06-24" version="1" fragment="single">MALGAGGLTAGPAAASAAASVPASASASAYGPQAPQNPFTAANGAATMHGDSASSGTTAYPGPGTSGISYSRTALASACPTVVVGGDGYVIALCTTIFGRTPTVHLLDPGTGADLASLALPKGSLFGGVYAYLDNADRLVVVDGSNSLVRVGHHRTGSGWELRIDQSTPLGGAVPAGDNIVGLTPDWDGRVWFATSGGVIGTVDTGTGTVRSISTGEGVQNSISTVPGRTAVATDHALYLLSAAPDGTPVVDWRAPYDRGPARKPGQLSWGTGTTPSFFGPEQGTEYVTIVDNADPHGNLLVYRAAGGPDPICRIPVLTQYARSGTEDAVIASGRSVFVTNTYGYPYPALPEGAPASQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX86</accession>
    <name>A0A0F4IX86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_30495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000961">
        <property type="protein sequence ID" value="KJY26264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950850.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000961.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26264">
        <property type="protein sequence ID" value="KJY26264"/>
        <property type="gene ID" value="VR44_30495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2514"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="276"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="7">
        <location>
            <begin position="444"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="604" mass="64132" checksum="BD553DBAE6ED9E5F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX89</accession>
    <name>A0A0F4IX89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_32840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001095">
        <property type="protein sequence ID" value="KJY25296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25296">
        <property type="protein sequence ID" value="KJY25296"/>
        <property type="gene ID" value="VR44_32840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="37409" checksum="CBC7F0ECACCCBC54" modified="2015-06-24" version="1" fragment="single">MDGGPAIPHQPDVSDGPGAGDNRFAVLGPIRAWRGSQALPSGSPQQRALLAALLLRDGRTATAPELIDAIWGEDPPQQALATIRTYASRLRKVLDPGLLVSDAGGYAIRLRHQEALDLGVARTLASGAEQARAAGDRALARTLLARALDLWDGEPLAGVPGPHAETERTRLTEWRFQLLETRLDLDLEVGQHAEAVSELTALTAAHPLRERLRELLMLALYRSGRQAEALAVYADTRRLLAEELGVDPRPELSALQQRILNADAELARTEDPAPAAAPSVVRPAQLPATVPDFTGRAPFVSELGEILSGSDGQVMAVSALAGIGGVGKTTLAVHVAHAARPHFPDGQLYVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXF7</accession>
    <name>A0A0F4IXF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_30785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000978">
        <property type="protein sequence ID" value="KJY26133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26133">
        <property type="protein sequence ID" value="KJY26133"/>
        <property type="gene ID" value="VR44_30785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2614"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470514" evidence="5">
        <location>
            <begin position="46"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="31809" checksum="81677FD664DFB29B" modified="2015-06-24" version="1" fragment="single">AGRRVRRWLRGRPSALAATAVLALLVLLALAAPLLAHLTGQDPNAYHDDLVDSARGGVPLGSFGGISADHWLGVEPGTGRDLFTRLLYGAQVSLLVSLGATAVQVAIGVAAGITAALGSPLLGRLIGGTTDVMIALPLLVLAVALTAVVPPGFPRPLLLVLVIGVLDWGGTARLVRAQTLSLRGLDFVEAARLAGNGRLRIARRELLPSLAAPVITLAALKVPTNMVIEASLSFLGVGVKPPTPSWGQMLSSAQTWFRADPAYVLLPAGLLFVTVLSFTVLGDGIRTALDPREGSRLRVGTGKEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYF5</accession>
    <name>A0A0F4IYF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950500.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27032">
        <property type="protein sequence ID" value="KJY27032"/>
        <property type="gene ID" value="VR44_28560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2041"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="4">
        <location>
            <begin position="257"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="41877" checksum="680C4FCEC3007B27" modified="2015-06-24" version="1">MSSAAASAAPVITGIGVAAPNGLGTEAWWSAVLRGESGIRPVTRFDAGQYPAKLAGEVQGFDAAAHLPGRLLPQTDQVTRLALTAADEALADAGVDPAELPDYAAGVITASSAGGYEFGQRELQALWSKGGQYVSAYQSFAWFYAVNSGQISIKNGMRGPNSVLVSEQAGGLDAVAQARRQLRKGIRLVVTGGMDSSLCPWGWAAHLASGELSTSEDLERAYLPFSEEAGGHVVGEGGALLVLEDGASARERGARPYGEVAGYAATFDPPPGSGGAPRLRDAAALALREAGLAPADVDVVFADAAGRREADRAEAEALAELFGEYGVPVTAPKTMTGRLAAGGASLDLAAALLSLRDGVIPPTVHAGPPAADCPLDLVTGVRRPARLRTALVLARGRGGFNAAMVVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYR7</accession>
    <name>A0A0F4IYR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25816">
        <property type="protein sequence ID" value="KJY25816"/>
        <property type="gene ID" value="VR44_31510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2797"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19951" checksum="F5B0DF1CE633403E" modified="2015-06-24" version="1" fragment="single">CHPFRHGRWLWMHNGAIADFPRLQRDLCMAVDPALFPFMEGSTDSEVMFYLAVTFGLDQDVPGAVARMAGFVERLGKEHGVLEPLQMTVAVSDGQRVWAFRYSSQGASRSLFYSSRADTVRHLHPDLGYLREISDDTRIVVSEPLGDLPGMWNELPEASCAVIPSGPEPDYLPFLPDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYW8</accession>
    <name>A0A0F4IYW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_28145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000857">
        <property type="protein sequence ID" value="KJY27220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950423.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000857.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27220">
        <property type="protein sequence ID" value="KJY27220"/>
        <property type="gene ID" value="VR44_28145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="365" mass="38857" checksum="6D38CBF146BB1E4F" modified="2015-06-24" version="1" fragment="single">MIEAVGLTKRFGAKTAVDQLSFQVKPGHVTGFLGPNGSGKSTTMRMILGLDRPTSGHVTINGLPFRELPNAQRHVGALLDAKSVHGGRRARTHLLSIAQLSGIPEKRVDEVLGVVGLQAAARQRTKGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGILWVRNLMRQLAAEGRTVFVSSHLMSEMALTADHLIVIGRGRLLADMSTQDFITHNSAGFARVRAAGGDPEGRASLAAALTGAGGRVLQEPDGALRVTGLELPRISDLAHEAGVRLWELSPHRASLEEAYMRMTQTSVEYTSTDDPRAELWEPEPLALPEWEDESAAAVAPETAASFFAPPPPGSGRRPFLMPDSAADLASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZC6</accession>
    <name>A0A0F4IZC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000898">
        <property type="protein sequence ID" value="KJY26838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26838">
        <property type="protein sequence ID" value="KJY26838"/>
        <property type="gene ID" value="VR44_29095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2153"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9163" checksum="DF8D5E6B0189B896" modified="2015-06-24" version="1">MDLPEHFGSWKGAHNRLRMWAADGTWEKVFTALLAQADTEGDLDWVVAVDSTIVRAHQHAAGARQKGLRPASRPTMPSDAPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J074</accession>
    <name>A0A0F4J074_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000808">
        <property type="protein sequence ID" value="KJY27670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27670">
        <property type="protein sequence ID" value="KJY27670"/>
        <property type="gene ID" value="VR44_27090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470447" evidence="1">
        <location>
            <begin position="38"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="116"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="37873" checksum="06252CA497E47E99" modified="2015-06-24" version="1" fragment="single">MTRGINHVIRNATLGSAATLITGALAAGLLLAPSASAAPARKDNGPAEAVGAQIAAARAARAGIDWKDCPADWGFEKPIQCGWVKVPLDYAKPFGKTIDIAVDRAVSTGTKEERQGALVYNPGGPGGSGMRFPRRVTTKSPLWVNTSKAYDFVGFDPRGVGHSAPISCIDPQEFVKAPKADPVPSSEADKLAQRKLAAEYADGCKERSGEMLPHMTTTNTARDLDVIRAALGEKKLNYLGVSYGTYLGGVYATLFPGHVRRMIVDSVVNPDTDNIWYQANLEQDVAFQTRWNDWQDWVAKYDSTFHLGDTRAKVEAKYQELRAQAKAKPLGGVVGPNELIGFFQKAPYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0F0</accession>
    <name>A0A0F4J0F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000801">
        <property type="protein sequence ID" value="KJY27742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950193.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000801.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27742">
        <property type="protein sequence ID" value="KJY27742"/>
        <property type="gene ID" value="VR44_26870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1533"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23481" checksum="888BBAFC121033DB" modified="2015-06-24" version="1">MARPRKPLLSRDRIVEAAGELVDAEGLEAVSTRRLAAALGVSGPSLYNHFRTKDAILEAVADAVSARVDLSMFDGVDGPSDWRPALHAWAHSYRAALADHPNIVPVLARGPGRRPAGLRLADAVFGAMTAAGWPPAQATRIGALMRYFILGSAVASFAQGFVDDETAYDPADYPHLGQAHLLADRRHEVDEGAFETGLTALLDGLTLQYEALRPEPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0J0</accession>
    <name>A0A0F4J0J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_28045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000855">
        <property type="protein sequence ID" value="KJY27248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950405.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000855.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27248">
        <property type="protein sequence ID" value="KJY27248"/>
        <property type="gene ID" value="VR44_28045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1822"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="253"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY27248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="484" mass="50646" checksum="976502BDBC900BA9" modified="2015-06-24" version="1">MTSPAARFRTLPLRSRLALLVTVAVAVAVAAVAGVAWVMVRAQLNEQLNQSLLSTQPDEQVVRTLREGCVTRPAVGTPNIAEELGPTVQIVTADGARCLVSGRSDLPVSGADKAVAAGLSAKSLHDATTGDGTRMRVYTINKHLTNGASFGVSIAKPLADVDQPLSTLAWVLLLVSGIGVVGAGAAGLWVARTGLRPVDELTGVVEHIARTEDLTVRIPEEGDDETARLSRSFNSMTAALASSQERQAQLIADAGHELRTPLTSLRTNIELLARSEETGRAIPPEDRRELLASLKAQMTELASLIGDLQELSRPDAAPHAPLGVVALHEIAGTALSRARLRGPELRFDAELEPWYVRGEAAALERAVVNLLDNAVKFSPPGGAVGVSLRAGELTVRDHGPGIPAEDLPYVFERFWRSESARALPGSGLGLSIVARTAARSGGTAELRAAADGAGGTEAVLRIPGAPTPPPSDQPSARGSVVPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J179</accession>
    <name>A0A0F4J179_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000911">
        <property type="protein sequence ID" value="KJY26681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950667.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000911.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26681">
        <property type="protein sequence ID" value="KJY26681"/>
        <property type="gene ID" value="VR44_29485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2263"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="46832" checksum="5CE0EC1E23298FE7" modified="2015-06-24" version="1">MDPTAPVPSGPEGPHPPLSAEERAEYVRLRKAASVRHKRVRYAGASVLLLLALLLSPIAVVSAWVDDTITDTDRYVQTVAPLADEPAVQNAVNDKLTAGVVANVDVKAITEALGRALKQADAPPLVVEKSQALEGPLKSALTSAVHAVVAKVVASDQFETVWTEANRRAQAAVVNVLTGEGSSAVASKGDTIVLDLGTLTDQLKERLTAAGFEKASAIPEVDKQIPLLKVDKLDKAQNAMRLLNVVGVWLPVVALALAALAIWCAPAHRVWLMATAIGVGVMMGVLLVALAVARRIYLDSVPPATLPPDAAAVIYDTLVRFLRESARTLIVVAVVTLLAAYLYGPGRGARVVRTEARRATGAGGRHLQRLGVRTGSTGRWLAGHGAWTTGVVIGAGALTLLLWNHPTPAVVAVVFGIVVLVLVLLGVLAAAPGDGPHPGKEAGHPTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1D6</accession>
    <name>A0A0F4J1D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000907">
        <property type="protein sequence ID" value="KJY26736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950632.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000907.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene185"/>
    <dbReference type="EnsemblBacteria" id="KJY26736">
        <property type="protein sequence ID" value="KJY26736"/>
        <property type="gene ID" value="VR44_29295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2211"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="38508" checksum="0BE479985095C3DD" modified="2015-06-24" version="1">MASVTFDKATRLYPGGDKPAVDQLELEIEDGEFLVLVGPSGCGKSTSLRMLAGLEDVNGGAIRIGDRDVTHLPPKDRDIAMVFQNYALYPHMTVADNMGFALKIAGEDKATIRRKVEEAAKMLDLTQYLDRKPKALSGGQRQRVAMGRAIVRKPQVFLMDEPLSNLDAKLRVSTRTQIAALQRDLGITTVYVTHDQVEAMTMGDRVAVLKDGLLQQVDTPRNMYDRPANLFVAGFIGSPAMNLVEVPITDGGVKFGDSVVPVSREALSAAADAGDKTVTVGVRPEHFDIGETGGLTITVNVVEELGADGYVYGSKDGQDIVVRVGGRQVPEKGSSLHVVPRAGEMHVFSTSTGARLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1P1</accession>
    <name>A0A0F4J1P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2075 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000899">
        <property type="protein sequence ID" value="KJY26831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26831">
        <property type="protein sequence ID" value="KJY26831"/>
        <property type="gene ID" value="VR44_29100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2075" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="30004" checksum="785289E6C05066C7" modified="2015-06-24" version="1" fragment="single">MVVFLDERQVIRPGEGFTVEDIRRIAHRHGRRHRAHELRESFRCRGSKAYTDWVDALLYGTPAPWSGPEGYDLDTAPDPFALQQWIDTSTRNGILARTAAGFCWTWDRTVRKNGILKPEVRIEHRDPATGTNRLWQAAWNAATRVITPDGIVTAPASRLWASHRGGHQQIGCVYTAQGLEYQHAGVIIGDDLTWEDDRWVAHPERSHDNTLKHLPPEEYLRYALNTYRVLLTRGASATRIYHTHAPSQHMLNRLGRFFQIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J247</accession>
    <name>A0A0F4J247_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_25515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949937.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28387">
        <property type="protein sequence ID" value="KJY28387"/>
        <property type="gene ID" value="VR44_25515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1201"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="571" mass="59063" checksum="26BB18DC17A86F41" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J353</accession>
    <name>A0A0F4J353_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">VR44_24845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949809.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7584"/>
    <dbReference type="EnsemblBacteria" id="KJY28670">
        <property type="protein sequence ID" value="KJY28670"/>
        <property type="gene ID" value="VR44_24845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.968"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="33676" checksum="FD94114729134108" modified="2015-06-24" version="1">MRNAAPAPRVIAVVGPTAAGKSDLGVALARHFDGEVVNADSMQLYRGMDIGTAKLTMDERGGVPHHLLDIWDVTETASVAEYQRLARAEIDKLLAQGRTPVLVGGSGLYVRGALDAMEFPGTDPEVRARLEEEATLRGPGALHARLAAADPAAAAAILPSNSRRIVRALEVIEITGKPFTANLPGHESVYDTVQIGVDVARPELDERIATRVDRMWEAGLVDEVRALEAQGLREGITASRALGYQQVLAALAGECTEDEARAETVRATKRFARRQDSWFRRDPRVHWLSGAAADRGELPRLAQSLVERAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6C0</accession>
    <name>A0A0F4J6C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29912">
        <property type="protein sequence ID" value="KJY29912"/>
        <property type="gene ID" value="VR44_21635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.205"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19212" checksum="182D45301C2795EB" modified="2015-06-24" version="1" fragment="single">TVLAGPASAAPAVVSRDNNQVVYTAQPGETNTVTFSTPGGWLQVEDKTSRMIPGSGCSRFNNDPHIIRCGHSAAVTRLQASLGDRDDVVRNETSIPSDLTGGPGDDMLIGGSGPDRLIDSDGWNAAPGSNTFEGRGGNDTIISRNGGYDRIDCGESLADADILLADPATLDHLVPNTCEYVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6F8</accession>
    <name>A0A0F4J6F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949303.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000615.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29795">
        <property type="protein sequence ID" value="KJY29795"/>
        <property type="gene ID" value="VR44_22070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.294"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="32286" checksum="1819DC69E7FA625C" modified="2015-06-24" version="1">MLERLNQAMEYVEAHLDQRIEVSELARITVTSEYHLRRLFSSLAGMPLSEYVRRRRLTVAGAAVLAGEPTLLEIAVRYGYTSGEAFARAFRAVHGVGPGEARRTGAALSSQPRLSFRLTVEGNSTMRYRIVEKESFRVVGRKARVPLIYQGVNPHIAEHIRSIPAETMLRIAGFSDQDPEGVVSATVRLSDGFEEGSELDYYHCVVTAAAAAGLPGDLDVLDCPAGTWAVFENSGPFPQALQQMWADVAAQWIPSNPYEYRPGPEILRTRPHPGEPEHSDAQLWIPVTRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6T5</accession>
    <name>A0A0F4J6T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949826.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28641">
        <property type="protein sequence ID" value="KJY28641"/>
        <property type="gene ID" value="VR44_24925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.985"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470781" evidence="4">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="30121" checksum="7030EFC48F72A912" modified="2015-06-24" version="1">MKVLKAGAAVATAVVLALTATACGGGSKDTASDAGASGGTKSDKIVIGIKFDQPGMGLKTPDGKFEGFDVDVATYVAKELGYQPDQIEWKQAVSAERENLISNGDVKFIAATYSINDKRKAKVDFAGPYFLAHQDLLVRADDNSITKVEDLNKKKLCSVTGSTSAQNIKKDLAKDADLQEFPGYSECLTGLENKAVDALTTDDSILAGYAAQEKNKGKFKLVGLKMSNENYGIGLKKGDKDLQTKINAALKKMVADGSWEAAVKKNLGPANYKNEPAPQITEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6U6</accession>
    <name>A0A0F4J6U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949223.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000605.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29915">
        <property type="protein sequence ID" value="KJY29915"/>
        <property type="gene ID" value="VR44_21650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.208"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="34098" checksum="6B2FE94F79892B05" modified="2015-06-24" version="1">MNAQGGLGEQAGRPVRWRAAMEAALYGPGGFYVRPGGPGPAGHFRTSVHASPLYAGAVARLLASVDAELGHPERLDLVDVGAGRGELLAGVLAALPRETAARVVPYAVERAAAPEGLDPRIRWVDAPPEGTTGLLFANEWLDNVPLEIAEDGRYVLVAPDGTETPGGPLGTADRAWLERWWPGGEREGRAEIGRARDEAWAAAVATLDRGLAVAVDYAHTREARPPYGTLTGFRGGREVAPVPDGGCDVTAHVALDSCAGPGAVLLTQREALTALGVSGGRPPLALASTDPAAYVRALASAGEAAELTARGGLGDFGWLLQPVGVPLPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J784</accession>
    <name>A0A0F4J784_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949754.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28801">
        <property type="protein sequence ID" value="KJY28801"/>
        <property type="gene ID" value="VR44_24520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.899"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470448" evidence="1">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18053" checksum="96E91AE6BF2C7BEE" modified="2015-06-24" version="1">MRHHPHRRRIVALATGALLTAGLALAAPASAAAPAAVRSTTPLVVNARWGGHCTYDRIVIDLQGSVPPFTVTPVSQLVYDGSGKPVPLPGKYFLEIRLHPAAGHDDAGNNVYQGPKLQQIGLSKLKGIALTGDYEGYVTFGAAFDTQPAYSTSVLHAPERLVVDVAHPNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7F0</accession>
    <name>A0A0F4J7F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_21200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5041"/>
    <dbReference type="EnsemblBacteria" id="KJY30110">
        <property type="protein sequence ID" value="KJY30110"/>
        <property type="gene ID" value="VR44_21200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8963"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="60"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="30701" checksum="8BACD7715E0A7B1A" modified="2015-06-24" version="1">MTGSADRPAAEGTLLTRLRAPRRPRIWFEVLLIGISYWTYSLIRNAVPEQKAAALANADWIWSVERGLGIAVEHSVNHAVNSVTWLVVGMNYYYATLHFIVTIGVLVWIYRFHPGRYAATRLVLFATTGVALLGYFFFPLAPPRLMNGGHFIDTVLVHHTWGSMASGNLKHMSNQYAAMPSMHIGWSLWCGLTIFAVASAPWARILGLLYPAATLVVIVSTANHFWLDALGGMLCLAFGYTVSRTWYGALPHRLPRSPLDTAPHPATAALLNRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8B1</accession>
    <name>A0A0F4J8B1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">VR44_20515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000565">
        <property type="protein sequence ID" value="KJY30425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949011.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000565.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1079"/>
    <dbReference type="EnsemblBacteria" id="KJY30425">
        <property type="protein sequence ID" value="KJY30425"/>
        <property type="gene ID" value="VR44_20515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8813"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10887" checksum="9F4CA5E06832F0A1" modified="2015-06-24" version="1">MTTASSKVAIKPLEDRIVVQPLDAEQTTASGLVIPDAAKEKPQEGVVLAVGPGRFEDGQRLPLDVSVGDIVLYSKYGGTEVKYSGEEYLVLSARDVLAIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Z6</accession>
    <name>A0A0F4J8Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949083.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30228">
        <property type="protein sequence ID" value="KJY30228"/>
        <property type="gene ID" value="VR44_20910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="12975" checksum="11E207F6CF9D2727" modified="2015-06-24" version="1">MTTIETTVARRGVVFVRAAVAAQTVAIFFQALTAGLLLSTSYGELLHGVGARVMYGASMLYVLAAVLAWRPGGGSPRPVLYAGGFLALASVQVVLGIAHVPSVHVPLGVLMFGLSVLDLGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9V0</accession>
    <name>A0A0F4J9V0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948932.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30579">
        <property type="protein sequence ID" value="KJY30579"/>
        <property type="gene ID" value="VR44_20075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8637"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02155">
        <property type="entry name" value="PA_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="340"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="442" mass="48929" checksum="F4F1B2EE348E9015" modified="2015-06-24" version="1">MAAYTEDDDLGDEAERLGPDELAALQLKRLRATLHRVYDRVPFYREAFDKAGVHPDDCRSLADLALFPLTTKADLRAQYPFGMFAVPRADVRRLHASSGTTGRPTVVGYTDGDLAAWADVVARSLRAAGARPGQIVHIAYGYGLFTGGLGAHYGAERLGCTVVPASGGMTDRQVRLIQDLRPEVVMVTPSYMLTLLDEMERQGIDPRSTSLRTGVFGAEPWTEEMRREIEDRLGIDAVDIYGLSEVMGPGVAQEFASHKDGLHIWEDHFYPEVIDPLTGAVLPDGEFGELVFTSLTKEAMPLIRYRTRDLTRLLPGTARPAFRRMEKVTGRSDDMIILRGVNLYPTQIEEILLRIPALAPHFQLRLTREGRMDALTVRVEARRESDAGQRRAAAAELGRAVKEGVGVSVGVEVVEPETLERSVGKIKRIKDLRETGEGPEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z0</accession>
    <name>A0A0F4J9Z0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">VR44_20130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948939.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000555.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30558">
        <property type="protein sequence ID" value="KJY30558"/>
        <property type="gene ID" value="VR44_20130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8731"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="32060" checksum="73BE1A345F83ED4C" modified="2015-06-24" version="1">MPQHAASEVPVLSEEVREALAARRPVVALESTILAHGLPRPRNLAVGLELEELVRAEGAVPATVAVVDGVAYAGLDKARLERIAAGEGVRKLGHRDLAPALAAGATGATTVSATAFLAARAGLRVFATGGLGGVHREFAQTQDESADLSLLARTRITVVCAGVKSILDVPATLQRLETLGVGVVGYRTRTFPGFYLADSGEPVDWTVERPQEVAEMMAAQDALAGPESALVVANPVAAAEQLDPGLHDRVLAQALAECRERGITGQAVTPFLLGFLVRATGGASLEANLAAVRGNVRLGARIAGAWAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA31</accession>
    <name>A0A0F4JA31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000552">
        <property type="protein sequence ID" value="KJY30603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948923.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000552.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30603">
        <property type="protein sequence ID" value="KJY30603"/>
        <property type="gene ID" value="VR44_20030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8628"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7565" checksum="F9B8C29352F63D65" modified="2015-06-24" version="1">MKVPEGVTQPKCGADTERGGRCRNKAILGSGQCAKHQGRWTRRGVAQAEAKEAKAKLRGLSKKKWSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAZ4</accession>
    <name>A0A0F4JAZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948579.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31385">
        <property type="protein sequence ID" value="KJY31385"/>
        <property type="gene ID" value="VR44_18200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8187"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470279" evidence="2">
        <location>
            <begin position="36"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="27339" checksum="17AD4E418B4C2C24" modified="2015-06-24" version="1">MHRSASRLTRVLACAAVPVILTVAGCSSDSGKSSSASGSGKKSPSSSSSSQSGAKGSATLEKVAFAKLPDPCKSVPAKTVEALVHDAKDKNGTAAKSNDLANRASCSWNGLETDGTKGSQYRWLSVSLVRYDSHASLGSGNKRAEEQYNKQIELAKTTKDAHDVKVEQAGGVGDQGTSVVYGIKKDVDFFNTTVIARTQNVVITLDFNGAAYEGAGAPDQAKLLQDAINATKEVVTSVANGGTEQAPSGAESPSGSASPSASASPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB36</accession>
    <name>A0A0F4JB36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948779.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30948">
        <property type="protein sequence ID" value="KJY30948"/>
        <property type="gene ID" value="VR44_19240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8454"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470538" evidence="2">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="27363" checksum="3D9ABA0261774920" modified="2015-06-24" version="1">MVCALGAAVCFGTASVLQAMAARAAARPEAAGSGVDTALFLRAVRQWRYLAGLGLDAVGFVLQIIALRHIPIYAVGAALAASLAVTAVVSAPLLGARLSRLEWGAVAVVCAGLLMLGLASGEEGDGEGTLALKLGLLAVAGLVLLVGAVAGRLPEGSRALVLGLAAGTGFGVVEVSVRLIDSLSLRELGNPALYALLLGGAAAFLLLTSALERGSVTAATAGLVLGETVWPALVGVVWLGDRPREGLAWLAVTGFAVAVAGALALSRFGEPKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC01</accession>
    <name>A0A0F4JC01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000472">
        <property type="protein sequence ID" value="KJY31730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948465.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000472.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31730">
        <property type="protein sequence ID" value="KJY31730"/>
        <property type="gene ID" value="VR44_17600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8084"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12435" checksum="EDF90C5D2A0E2F43" modified="2015-06-24" version="1">MARELPPPGSGPAADPIIQQALDQASTPDLPPDDEQRLLELGRTAWTAETTGYTQVRIQAATARRDTTAPAGGERTQVQAVVRLVWVGADPAGTFLDGRTAALHYTRNGQGSWKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCL9</accession>
    <name>A0A0F4JCL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948551.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000491.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31478">
        <property type="protein sequence ID" value="KJY31478"/>
        <property type="gene ID" value="VR44_18060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8159"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470813" evidence="1">
        <location>
            <begin position="29"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="38818" checksum="3392EE5C4EBA8A07" modified="2015-06-24" version="1">MKKALLAATAVVASALTASLVVAPAASASGWEWPGRHHDRTSIPFTEATVTAAADGSYALKWNAKGTRHVEIKANGKVVAKGGAQGRATVQGLPAADRQWFDFKADHGQGLHLADRQVKLEGAVNFRDIGGYRTTTGQWVKMGEVYRSDALDKLTANDRAKLQRLRVKTVFDLRTQDERGKDADRVPAGARYVVADVFAGSGSFQTMPKSPDEAVQAMIGAERSMVSGEGGKKAYAQVLDGVRDDRAHAVLFHCTAGKDRTGWADATLLTALGVPQETVLADYLASNDYRKAANEAILSRLPAPQAAVYKPMLDVRPEYLNAGYDEVKAKYGTFDRYLKDGLGLDARELRDLKRDLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDM6</accession>
    <name>A0A0F4JDM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31066">
        <property type="protein sequence ID" value="KJY31066"/>
        <property type="gene ID" value="VR44_19000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8404"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="554" mass="57642" checksum="49D8AD375DC96128" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDP4</accession>
    <name>A0A0F4JDP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948720.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000518.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3421"/>
    <dbReference type="EnsemblBacteria" id="KJY31091">
        <property type="protein sequence ID" value="KJY31091"/>
        <property type="gene ID" value="VR44_18930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8327"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="43152" checksum="3CFCBABA1BFF0C72" modified="2015-06-24" version="1">MSYSAPPNWQDEPDLLDLAGAPVPHYGTGSLADLLPTLAAGQGVPGLTAGIAELTPADRNCVFLVDGMGWEQIKAHPEYAPFLTSLLASSRGGTGRPLTAGFPATTATSLASVGTGLPPARHGLPGYAVRNPASGELMNQLRWQPWTPPKPWQPYPTVFQLADAAGVHTAQVSAPNFQSTPLTQIALSGGTFHGRMTGEERMDLAAIQLAAGERSLVYTYYSELDGAGHRHGVDSDAWRGQLMYVDRLVQRLAEQLPPRTALYVTADHGMVDVPFDEDSRIDFDEDWELGAGVALLGGEGRARHVYAVPGAEADVLTVWREVLGDRFWVASREEALELGWFGAPGECDERVLGRIGDVIAAAIAAAQADVAITASRNEPNESALTGMHGSMTAAEQLVPLLEVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDP6</accession>
    <name>A0A0F4JDP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948375.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31919">
        <property type="protein sequence ID" value="KJY31919"/>
        <property type="gene ID" value="VR44_17120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7956"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="434" mass="44329" checksum="E241401D3111F793" modified="2015-06-24" version="1">MRGDETQRGVAPGAESRERKGRHAAPRKSLLNKLQIPVGKTMALAAMPTAVLVGMGMAPKMALADDKDIPFAPGPCVTRSDEPSASASPSPSGSPSATPSPGASPGASPSPGASQAPKPGVSPAATPSAKQPEAPKERKQETPAATPSASASPSPSATKTTNPLDPLGVGDALKGLVDGLGKPLQGAQKPAAPAPAPSTSGTPKAPAADPTADAIRDAAKKAGATVEELPQDVKDTVKTPKDESGKTAADEDGTDGASPSPSATVDPDGKQPFPCPTFDAKALADAKLEQGIPLLPDEPWYLDSSLLTLYGLDYEGIVEVKTASGKTKKVLKFTADSLDIKDLYQTVGKTGNVAHLKSRPGSTSKIRDGKVTMYTESLKGNLFGLIPIEFTPNSPPPLNVPFAFFTHVKVVQAGQFGGNLTVPGLHNYIGPPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDU5</accession>
    <name>A0A0F4JDU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000408">
        <property type="protein sequence ID" value="KJY32512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32512">
        <property type="protein sequence ID" value="KJY32512"/>
        <property type="gene ID" value="VR44_15830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7574"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21233" checksum="76C3B45D5A0D9B68" modified="2015-06-24" version="1">MPADPEAADWLWKWVTENGPQGVPGGVDLSSLDLSGADLSGADLSSSLLCAADLARTRLTGTDFYRSHLQGADLTGADATGACFVRADLDGAVLRGTTLDGADLTRADLYGADARGATLRGARLLGATLLHTDLRGADLTGARLGENPFEVTLDDTTTVTGLTGTLQGPVTLPDTPHPLTGPALEHWLRTHGSNARVVPPRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGI2</accession>
    <name>A0A0F4JGI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">VR44_14130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000364">
        <property type="protein sequence ID" value="KJY33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947829.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3373"/>
    <dbReference type="EnsemblBacteria" id="KJY33325">
        <property type="protein sequence ID" value="KJY33325"/>
        <property type="gene ID" value="VR44_14130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7172"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="42786" checksum="8E4C6B2FCAD56FA5" modified="2015-06-24" version="1">MDKPKVVLGVSGGIAAYKACELLRRLTESGHEVRVVPTASALNFVGEATWAALSGNPASTEVWESVDEVPHVRIGQSADLVVVAPATADMLAKAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWEHPATQENVATLRRRGAVVIEPAVGRLTGKDTGKGRLPDPEEIFEVCRAVLARGAAAPDLAGRHVVISAGGTREPLDPVRFLGNRSSGKQGYALARTAVARGARVTLVAANTALADPAGADVVRVGTALQLRDAVLKAAADADAVVMAAAVADFRPAVYADGKIKKQEGREPDPVALVRNPDVLAEISAERALKGQVVVGFAAETDDVLDNGRAKLRRKGCDLLVVNEVGESKTFGSEENEAVILASDGGEVQVPYGPKEVLADVIWDQVASRLAPPSELRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGZ9</accession>
    <name>A0A0F4JGZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000349">
        <property type="protein sequence ID" value="KJY33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947736.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000349.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33627">
        <property type="protein sequence ID" value="KJY33627"/>
        <property type="gene ID" value="VR44_13615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6984"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12416" checksum="BBE35AF67791F770" modified="2015-06-24" version="1">MAQRKGCLIGCGVALVLGVGVLVALFLGLGKMADVADKTLLDPKVYASVNVGDPESEVRAKLPSGETFVKAALKEGGPAEPAGSVCAWYVSSDGKAAEDVLRLCFKDGKLAEKAQYRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIA5</accession>
    <name>A0A0F4JIA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000314">
        <property type="protein sequence ID" value="KJY34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34082">
        <property type="protein sequence ID" value="KJY34082"/>
        <property type="gene ID" value="VR44_12640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="57" mass="6523" checksum="34B29116AB1F6645" modified="2015-06-24" version="1" fragment="single">DVYKRQTVSSLSAEEYLRRIEAAGLEVLHHETTLFHPAGALADPEEHLFCYARRPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJV5</accession>
    <name>A0A0F4JJV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34465">
        <property type="protein sequence ID" value="KJY34465"/>
        <property type="gene ID" value="VR44_11845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6374"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="18367" checksum="339204E9BCC4F136" modified="2015-06-24" version="1">MSLRVNGARRDLDLDHRVTLLDALREHLDLTGSKKGCDHGQCGACTVLVDGRRANSCLLLAVTLDGCGITTVEGLAAPDGALHPLQRAFVEHDAFQCGYCTPGQLCSAVGALREAAAGHPSHVTADAAQAGPAVLTAEEIRERLSGNLCRCGAYPAIVRAVADAGTDPAATGTAVEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJX4</accession>
    <name>A0A0F4JJX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000316">
        <property type="protein sequence ID" value="KJY34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947561.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000316.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34068">
        <property type="protein sequence ID" value="KJY34068"/>
        <property type="gene ID" value="VR44_12675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6614"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470589" evidence="2">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="28433" checksum="DE3DF9FF0BEFE128" modified="2015-06-24" version="1">MRSRTKSRAVAAATAAAALLGGLTACGPAGQRAGADRPASPGASAAASAPASASASPAAARSGQEILTEAYEATRKAESMRVAATVQQDGKPMKVDLSLDRKGNCKGEIRVDGMGRLDVIKSSESVHFRGDTAYWRGAAKMKHAPQKQADQMVAMLADRWIRIPASDPRAAPMTGSCDLSKLTGDLDHASPLARKGETATVDGKQTLAVTSPAKQGTQTDYVATQGKPYILKSTVMGDSTGEALFSAFDVPVDTTSPKDADVLDMSKLGGPAGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK35</accession>
    <name>A0A0F4JK35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_11655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000281">
        <property type="protein sequence ID" value="KJY34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34545">
        <property type="protein sequence ID" value="KJY34545"/>
        <property type="gene ID" value="VR44_11655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6297"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="282"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="38477" checksum="446916F75FDF8A0E" modified="2015-06-24" version="1" fragment="single">AGLLALTAGRAVTDSAPRAGWVVAVCALLAAVYAAGVRAPAVGQSALAAGVWLAGTGAVWAALLVLSPDGLWIAFPLYFLELHLLRLRWGLAAVAVTACAAIGGFLGHSGAVTPGAFLGPLLGGAVAVATVLGYQALYRESERRRELIEELIATRAELAAAERGAGILAERERLAREIHDTLAQGLSSIQLLLRAAERALSEDPAAGSPTPAAAALAHIGRAREENLAEARRFVRALTPPDLEHGSLAAALERLCSGAPGPRVRFSVSGTPRELPTPYEVALLRIAQSALANVVRHARADRAEITLTFMDTSVTLDVVDDGRGFDPASAPSGEGGFGLPAMRARAESLGGLFTVESAPGQGSAVAVTLPLPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKM7</accession>
    <name>A0A0F4JKM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947424.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34379">
        <property type="protein sequence ID" value="KJY34379"/>
        <property type="gene ID" value="VR44_11950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="27900" checksum="47ECC548B840D14F" modified="2015-06-24" version="1" fragment="single">MTSTWDPPPPRRSGTSVLPVLIPIAVLIVAAVAVGSWLQFSERQAADTVRTAGSGAADRVDVEATVQRVDAAGRELVLRVRVVPRGALGEEDGTAPVADLGLQTSAATVGDLAFKAHERLTTRDVRVALSGGSIGDYPFDTYETDIEFRAVMNGGRVPVRLLFSNNDTLFSVTAEPVSPRQEAALALSVARSGSLLVFAVFMMLVMWALAASVIIGTWYLTTQGEGLVWPALAWMAATLFALSAFRNTAPGTPPIGCVLDWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKT3</accession>
    <name>A0A0F4JKT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_11250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000261">
        <property type="protein sequence ID" value="KJY34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947294.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000261.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34810">
        <property type="protein sequence ID" value="KJY34810"/>
        <property type="gene ID" value="VR44_11250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6261"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="149"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24726" checksum="F5BD2310E3973B1D" modified="2015-06-24" version="1">MAGPRELPSDEVLVQRLRAGDEETFALVLDSWSGGMLRLAMSFVSTKDSAEEAVQDTWLAVIRGIDNFEGRASLKTWVYRILVNTAKARGTKESRTVPFASLLPEEEGPTVDAERFRAPGEQYAGHWVAGQEPRPWHIPEDHVLRGEVRELIAEAIDELPPRLRTVVTLRDVAGYGSEEVCSLLEISPGNQRVLLHRGRALLRRKLESYLFGAQGVAGGRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLW6</accession>
    <name>A0A0F4JLW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000229">
        <property type="protein sequence ID" value="KJY35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947131.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000229.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35347">
        <property type="protein sequence ID" value="KJY35347"/>
        <property type="gene ID" value="VR44_10375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5947"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="33850" checksum="DA4CACA2AFF9350F" modified="2015-06-24" version="1">MLRVHFTAEDFARTRFATRPAPLQELHAALATAVARSGGPLFAQWRGRVLRSLPAASGPLADLVPGGRPPSFLDVLGDTLADGFERIRATGPALVRSELERVYGATAAPRWIHGLHAGDEAAWHTLRRAQQTAYETVLAPVWSVVQDLHREQFSHYALTAAEHGVAAALTGLAPGSRLHEGVWEWPGAAPAREVRLDGRGLVLLPTFHHPAGPLLQDVPGRPAVLTYPAGAGLPPAAGNPVASAEALAAVLGRTRLHALRLLAEPHTTTSLARALHVSNATASSLAAALRSAGMATTTRTGRSVTHRRTALGTLVAGARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLZ2</accession>
    <name>A0A0F4JLZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Toxin_10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the toxin_10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947100.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35372">
        <property type="protein sequence ID" value="KJY35372"/>
        <property type="gene ID" value="VR44_10215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5909"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008872">
        <property type="entry name" value="Toxin_P42"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05431">
        <property type="entry name" value="Toxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Toxin_10" evidence="3">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="18423" checksum="9F86016C463A3E0B" modified="2015-06-24" version="1">MLVGSVLFPFPFINDPVLSRARQGQENPYYVLKRYGSWRNVYYYEHSGASAYTKEEEVTVGVTTSNTKEVEHTAGVKLTATSEFSFIGASTTLSVVSTTTTSTSENTRKTTVRREYPAGPRRAEAIWYREDRFVLERLNGEHVLEWAVRNPDRVITDAYPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQQ7</accession>
    <name>A0A0F4JQQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36697">
        <property type="protein sequence ID" value="KJY36697"/>
        <property type="gene ID" value="VR44_07425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3958"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="15863" checksum="EA13DC2C8C9D9B0A" modified="2015-06-24" version="1">MRGNVVDLAVAVVIGAAFTNIVNSIVKGIISPLVGAIGTKNLDVYTSCLKAPCGVDAKGEPTGVNIMWGSVLNATLTFLITAAVVYFLMVLPMAKYLSRQEARRKAREGVKETIEITELEVLKEIRDTLVSQRSGNGESARTPGARDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR32</accession>
    <name>A0A0F4JR32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946604.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene566"/>
    <dbReference type="EnsemblBacteria" id="KJY36640">
        <property type="protein sequence ID" value="KJY36640"/>
        <property type="gene ID" value="VR44_07570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3991"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="27403" checksum="0721171F93EB3D45" modified="2015-06-24" version="1">MGAGHAHKLYRHGHSPVHELPPHCKIAATAAFVIVVVSTPREAMWAFGLYAVLIAAVAAAARIPAGFLLRRLLIEVPFVLFAVLMPFVSQGERVDVLGMSLSVSGLWGAWNVLAKGTLGVAASVLLASTTELRALLLGLQRLKLPPLLVQIASFMIRYGDVITDELRRMSIARRSRGFEARGIQHWGVLAKTAGALFIRSYERGERVYLAMVSRGYAGSMPVIDDVTATRAQWAYSAVLPVTALAVCLMGWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRC1</accession>
    <name>A0A0F4JRC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000163">
        <property type="protein sequence ID" value="KJY36399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946711.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000163.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36399">
        <property type="protein sequence ID" value="KJY36399"/>
        <property type="gene ID" value="VR44_08110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4449"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471284" evidence="2">
        <location>
            <begin position="29"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="407"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="508" mass="53484" checksum="A13B7FE683B57C15" modified="2015-06-24" version="1">MAHHPRKTAAAAAALVALTGLGTAPSAAAPTPTAHARFVPGACPKTAEPVPELAKARCGFLEVPENRARPGGRTIRLATAVIPATSARPAAEPVVFMAGGPGGETFDDIPFLVSSGVNADHDLIVMAQRGNRYDQPNLACPEFDRFTARYVGLGHDSARAKSQMLDAFKQCRDRLTADGTDLGAYNTVENAADFADLRTALGIAEWNVYGYSYGTNLALTLLRTHPEGIRAVAIDSVTPPQSVVLPWGWPSAQEGIGAILDACAAQPACKSRYPDLRKTLDEQVRRLEEKPLTLTARPPKGGDPVKVVLDGGAVLNVLVANTIKPVDVPAAIDELARGNPERFARARAVDSVPAVGMTAHGLTESVACAEWTPGVSESDVLDAGRKAFPGWPDTVLAQTPQLPFQFDVCRTWNVPDRAAQQRVPAVSSVPVLLLSGTFDQKTGAEFAKDAARTLSRSTSVKIPGITHWVVPQSPCAAKVLASFLARPAAPDTGCAAGLTPAPFTITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRU9</accession>
    <name>A0A0F4JRU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946409.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37087">
        <property type="protein sequence ID" value="KJY37087"/>
        <property type="gene ID" value="VR44_06480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3209"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="30286" checksum="CCB20242E224C990" modified="2015-06-24" version="1">MFSEPDEPTAGRMRTARTTACTALGVQDRATDPVWGYEGRTLSGRVTGPDGGDGWLRLVSATEDRATGKLWEGPQSAHKALPAAVPRPALHRVHDWAADGFGYRAELYEHTPLATVSRSPVLADDVDLPESWWKELPLALDALATAATFREAVREEYIRRAVPQYTGHTVGEIQWSTAHGDFHWANLAGPELLILDWEGWGTAPYGFDAALLYLYALQAPDTATRVRQALAHILDDPAVRVAELTVCAQVLQAADRTPFYAALADPVRRHLGQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS44</accession>
    <name>A0A0F4JS44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946473.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36985">
        <property type="protein sequence ID" value="KJY36985"/>
        <property type="gene ID" value="VR44_06825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3445"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="636"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="739" mass="76922" checksum="C6AFBEFA1773297A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSJ6</accession>
    <name>A0A0F4JSJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000143">
        <property type="protein sequence ID" value="KJY36733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36733">
        <property type="protein sequence ID" value="KJY36733"/>
        <property type="gene ID" value="VR44_07320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3935"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="133"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="455" mass="48512" checksum="77E24E2F4AA346E1" modified="2015-06-24" version="1">MYAFDGHVPAVLLRLDRNPFHHGTLGAVRSLGRRGVEVHAVVEAGGGPVGRSRYLRATHPGPAGGLDPEAPEALLECLVGVSERIGRPAVLVAMDDLSAIAVSRVAPMLTDRFRIPHQPDDLPARVADKAELSRLCARWDIPHPETVIPQSGAEAARAAWTLGLPVVAKWSRPWLLPAGSGLRSTTLVDSATGARELYERSAEAGSPLLLQRFLPAGPDTDWFFHGAFGRGGRPLLAGTGRKELAWPVRAGLTAMGRWLADPAVEESGLRLAERLGYQGILDLDFRRDERGAVRLVDFNPRPGAQFRLFADDVGLDVVQAMYLDLTGQRVPEPAGGPGRVFLAENYALLAAVRGRTLPRPRGPVEAAWFAADDPGPFLAMLCAFLGRGLGKGARVLRGVPAQGRRTVRAVRAPRQRGGERARGDGVTAARPGAPGVPAPPGSPEASAEPDELVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT33</accession>
    <name>A0A0F4JT33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000103">
        <property type="protein sequence ID" value="KJY37517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37517">
        <property type="protein sequence ID" value="KJY37517"/>
        <property type="gene ID" value="VR44_05580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="23957" checksum="5CC35DF446C81575" modified="2015-06-24" version="1" fragment="single">MTSEQRVVVIGGGLAGLRLAARLGPAAAVTVLGEESHAPYNRVLLAEVLAGRYTPDVAALPAPGPVLRRGVRAVRIDRDVRRVHCDDGTAPEYDVLVLATGSNPVLPPLRGLFPPGGGELPEGVHAFRTMDDCLALDAAVRPGVRAVVIGGGLLGVSAARALAARGAHVVLAQQAERLMERQLDADSAALLREHLAGLGVEIHTECRVRGLTTTPAAGLTTAPPAFEALGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTQ1</accession>
    <name>A0A0F4JTQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37742">
        <property type="protein sequence ID" value="KJY37742"/>
        <property type="gene ID" value="VR44_05085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="11872" checksum="A6D9689D15331748" modified="2015-06-24" version="1" fragment="single">MNTNRGPAPRGHVAGLPDWDRCAVMGVVNVTPDSFSDGGRWFDTTAAVKRGLDLVAQGADLVDVGGESTRPGATRVDADEELRRVVPVVRGLASEGVAVSVDTMRATVAEQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUK4</accession>
    <name>A0A0F4JUK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000146">
        <property type="protein sequence ID" value="KJY36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946593.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000146.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36661">
        <property type="protein sequence ID" value="KJY36661"/>
        <property type="gene ID" value="VR44_07495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3974"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="38022" checksum="F11B99E85DC96D49" modified="2015-06-24" version="1">MSSSGLIYAVIVGAWAAYLVPMWLRRQDELNEARPTERFSTAIRLLSGRAGMERRYAKGLRERGEVQAEAQPHADPEAATETVNSVDADARALGVSPTRAEPRSVEVERVERVRRQQRLQVLARRRRTTALLFLAFSGGAIAAAVGGLRYLWAPAVPALLLSAYIVHLRVQERRRYEFTMDRRRAEAAARALRESRARHRDQGPESAGTAEPDPAPPVSPQEAGRRALVEQTDHAEWVDQQRERERGPARGDSWEPVPVPLPTYVTAPVAPRATGPVNPDGWSATRSSAAEPTNPRLRAQPGPAPAKPDPQPHPAAPRPRGRDAGRTPLFDQYESDERPRAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUN2</accession>
    <name>A0A0F4JUN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000102">
        <property type="protein sequence ID" value="KJY37529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946233.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37529">
        <property type="protein sequence ID" value="KJY37529"/>
        <property type="gene ID" value="VR44_05545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1921"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14494" checksum="287CD92C8AD093DF" modified="2015-06-24" version="1" fragment="single">FVYGTLRPGEANHRLFLRGRTAAEEPARLPGAVLYEGPGYPYAVERAGSGSGSGIAGELITPAAEAYGELLEALDLLEEYVGPGSPRNVYDRVAREAVRRDGSRVRAWVYLAAAPLAGRLALSGREIPGGDWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUS1</accession>
    <name>A0A0F4JUS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945994.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene840"/>
    <dbReference type="EnsemblBacteria" id="KJY38112">
        <property type="protein sequence ID" value="KJY38112"/>
        <property type="gene ID" value="VR44_04230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.136"/>
    <dbReference type="eggNOG" id="ENOG5032U30">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="10501" checksum="602E4206B488EE0F" modified="2015-06-24" version="1">MLDRRPTHDELVDHLVRTTALQRGEAARVVLDVLAYFDETTEEFVRRRHRELQSGGAVNAEIFERIAAELPHRAVAPPELSLRQLRRIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWI9</accession>
    <name>A0A0F4JWI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracenomycin C resistance and export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_02995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945767.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38737">
        <property type="protein sequence ID" value="KJY38737"/>
        <property type="gene ID" value="VR44_02995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7331"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="54423" checksum="07F97383CF79CBEC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWT4</accession>
    <name>A0A0F4JWT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000074">
        <property type="protein sequence ID" value="KJY38208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945956.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000074.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38208">
        <property type="protein sequence ID" value="KJY38208"/>
        <property type="gene ID" value="VR44_04035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8712"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19341" checksum="C788BD64B487ED84" modified="2015-06-24" version="1">MAEHRSMQRGALLDAARTLLSEGGTEALTFPALAERTGLARSSVYEYFKSRAAVVEELCAVDFPVWAAEIEAAMEAAPTPAAKIEAYVRSQLELVGDRRHRAVVAISAGELDAGAREKIRAAHGGLVAMIGEALEALGQPEPRLAALLLQGVVDAAARRIELGAAEDPAVITDTAVAMALRGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWY1</accession>
    <name>A0A0F4JWY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945797.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38645">
        <property type="protein sequence ID" value="KJY38645"/>
        <property type="gene ID" value="VR44_03125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7840"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="26"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="407" mass="42664" checksum="FC5C01E638596AAE" modified="2015-06-24" version="1">MSEVRDRWAALAERIDRGTPAGRDRAVDALRALAILGVVLGHWLVTALTTSDGALHGTSPLVRMPWLAPVSWVFQTLAVFFLVGGHVAARGYASARAHGVSYGAWAGRRLGRLFRPVAAVVAVWAVAAAGLLLGGAEWDTVRTLLTLVWSPLWFLLVFAALTAATPLVARLSPVWPLAVVAGVDVWRFGFGGPQWAGWVNVAAGWLVPYTLGAAWARGAFARRGPALLLLGGGAAATAALVLWGGYPASMVGVPGAAISNLNPPTLAAVAFGLAQCGLALLVREPLARVMRRPRTWAKVALLNLSAMTVFLWHQTSMMAVTALGLLVSTDLPGLHTVPGSGGWVVARLLWLPVFAGALAVCWAAFRVHERPRPRAVDRTAGAPGAGPEAGRPPGERRPAGSPAVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX41</accession>
    <name>A0A0F4JX41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">VR44_03815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000070">
        <property type="protein sequence ID" value="KJY38323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945919.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000070.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene778"/>
    <dbReference type="EnsemblBacteria" id="KJY38323">
        <property type="protein sequence ID" value="KJY38323"/>
        <property type="gene ID" value="VR44_03815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8666"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17707" checksum="EDBE98E3CEA3BC43" modified="2015-06-24" version="1">MRRAVCPGSFDPIHNGHLDVIGRASRLYDVVHVAVMINRSKQGLFTVEERIEMIREATADYGNVEVESFHGLLVDFCKERDIPAIVKGLRAVSDFDYELQMAQMNMGLSGVETLFVPTIPTYSFLSSSLVKEVAAWGGDVAHLLPEHVHAALIERLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXH4</accession>
    <name>A0A0F4JXH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ORF">VR44_02735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945732.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38855">
        <property type="protein sequence ID" value="KJY38855"/>
        <property type="gene ID" value="VR44_02735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6788"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="638" mass="67569" checksum="FC3A8C1536752B4B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXK2</accession>
    <name>A0A0F4JXK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945628.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39102">
        <property type="protein sequence ID" value="KJY39102"/>
        <property type="gene ID" value="VR44_02220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5709"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="47527" checksum="3133356E3C886211" modified="2015-06-24" version="1">MNSDADALRTVKDADRKHVFHSWSAQELIDPLAVAGAEGSYFWDYEGNRYLDFSSALVYTNIGYQHPKVAAAIAEQAGKLCTVAPGFAVDVRSEAARLIAERTPGDLDKIFFTNAGAEAVENAVRMARLHTGRPKVMSAYRSYHGATTTAINLTGDARRFGNDTATAGVVHFWGPFPYRSPFYAGSEAEECERALRHLEDTVVFEGPQSIAAIILETVGGAPGVLVPPAGYLAGVREICDRHGIVFILDEVMVGFGRTGKWFAAENWDVTPDLLCFAKGVTSGYVPLGGVAISSAIAETFARRPYPGGLTYSGHVLACAAAVATIGVMAEEGVVEQSARTGAELLGPGLRALAERHPSVGEVRGLGTFWALELVRDAGTREPLVPYNASGAENAPMAAFGAALKKGGLWPLLAGNRIHVAPPCNISAEDVAKGLEILDGALAVTDAHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY66</accession>
    <name>A0A0F4JY66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000086">
        <property type="protein sequence ID" value="KJY37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37921">
        <property type="protein sequence ID" value="KJY37921"/>
        <property type="gene ID" value="VR44_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="183"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="681"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1148" mass="118650" checksum="4BDA22F56D681323" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYC6</accession>
    <name>A0A0F4JYC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">VR44_04445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946031.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000060_gene2714"/>
    <dbReference type="EnsemblBacteria" id="KJY37976">
        <property type="protein sequence ID" value="KJY37976"/>
        <property type="gene ID" value="VR44_04445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.696"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="31"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="561" mass="60833" checksum="13FAD8752A3DF6EB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYR4</accession>
    <name>A0A0F4JYR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945497.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4191"/>
    <dbReference type="EnsemblBacteria" id="KJY39507">
        <property type="protein sequence ID" value="KJY39507"/>
        <property type="gene ID" value="VR44_01530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4739"/>
    <dbReference type="eggNOG" id="COG3938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="35483" checksum="0C03D973077B7292" modified="2015-06-24" version="1">MRTRHVYHAVDSHTEGMPTRVITGGVGVIPGATMADKRLHFIEHMDQLRTLLMYEPRGHAAMSGAILQPPTRPDADYGVLYIEVSGLLPMCGHGTIGVATVLVETGMVPVVEPVTTVRLDTPAGLVSVDVRVEDGAATAVTLTNVPSFCVGLDLKAEVPGFGTVTYDLAYGGNFYAFVELDALGLPFDRARKDDLIAAGLAVMDAVNASPDRPVHPENPSIAGVKHVYLAAPGSDARRSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGLLPLDTDFVNESFIGTEFTGRLVGETTVGGRPAVVPTVTGRAWITGTAQYFLDPTDPFPGGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ53</accession>
    <name>A0A0F4JZ53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945625.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39099">
        <property type="protein sequence ID" value="KJY39099"/>
        <property type="gene ID" value="VR44_02205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5706"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="36169" checksum="4DBBE03877EACBBC" modified="2015-06-24" version="1">MLELLGLDAQTADVYGLMLANHAWGVAEIAQRLRLTPADVRGSLEKLTDLRLLHRSAVGDELQPADPALGLRELLNERKRELESRQEAVARCEADMAQLVSTYSELYSGQTQRVSQQFLGVESVQNRIRELSTEATSECLTFNPGGAQSRASLEASKPLDRDSLDRGVRMRTVYLDSVRNDSVTTEYAEWLTDLGGEVRTVPSLPLRMLIFDRKTVIVPADPENTRKGAVQLTEPGVVVGLAGLFDQIWESAVPLGTRQDRDDRGLTRQEKELLRLLGSGLTDEAAGRQLGLSLRTVRRMMAELMKRLGAGSRFEAGLRAAQREWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZA5</accession>
    <name>A0A0F4JZA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cysteine synthase</fullName>
            <ecNumber evidence="4 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_02055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 10"/>
    <dbReference type="EMBL" id="JZWV01000028">
        <property type="protein sequence ID" value="KJY39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945595.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39159">
        <property type="protein sequence ID" value="KJY39159"/>
        <property type="gene ID" value="VR44_02055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5819"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34453" checksum="0A970E6E9FF808A3" modified="2015-06-24" version="1">MPLYDSILDTVGRTPIVRLNRLAPAHTTVYVKVEAFNPGGSVKDRLALSVVLDAEARGELKPGDTIVECTSGNVGIALAMVAAARGYHFVAVMGDTYSLERRQLIRAYGGKVILFPGALGSSGGNRIADELAEKHGWFRARQFDNPANPAYHRETTASEILADFAGKRLDYFVTGFGTSGTLTGVGQMLKTARPGVRIVATEPENAAILGKQEWNVHRIQGWSPNFVPSVLDDSVIDELVTIDETVGRDTSRRLAAEEGIFAGISAGATLATALRIAETAPEGSVLLAMLPDTGERYLSTFLMEGVNEGSDDEWLASLDSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZL3</accession>
    <name>A0A0F4JZL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_01340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945463.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39555">
        <property type="protein sequence ID" value="KJY39555"/>
        <property type="gene ID" value="VR44_01340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2984"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="199"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="36136" checksum="FB38275E607E693B" modified="2015-06-24" version="1">MDFHPSEEQAAAAALAARIYRDLATHERLAAAGTGSDAELWKALTAAGLTSAVEEVGLLGLVLLLEEQGRTTAQVPYAATCAYGILPVAAHGSPEQRARLLPALGSGEAVATGAFPARRAFTATPEGRLTGTAPAVPWLREATHVLVPDRDRALWLVRTDAPGVATRPVETTAPWSAGRLTLTGAPAERLGGPDAHDAVLAAARTAFAGLQAGVCAGSLARAVEYTSTREQFGRPLSTNQGVMLRAADAYMDTEAIRVTAYEAAWRIDEGLPAREHALTAAWWASEAGKRVVHAGQHLHGGMGADLDHPVHRHFLWGRQLDAYLGCGSELLSELGALISEGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1F2</accession>
    <name>A0A0F4K1F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000009">
        <property type="protein sequence ID" value="KJY39758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39758">
        <property type="protein sequence ID" value="KJY39758"/>
        <property type="gene ID" value="VR44_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoeA_N" evidence="2">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="12526" checksum="76B28E6E26F91D70" modified="2015-06-24" version="1" fragment="single">MTRTDADGALDEALALVSRTPAAEGGGGGHRATAWQRARETAALAGTTVRARNHRVALADALGEVLATSLDALGDLPSFDTSAMDGWAVAGPGPWAIRPGDGILAGGTGEGSPAPLADGEAVRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K465</accession>
    <name>A0A0F4K465_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945300.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39966">
        <property type="protein sequence ID" value="KJY39966"/>
        <property type="gene ID" value="VR44_00455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.90"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471487" evidence="1">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="25769" checksum="18B76D53E3EE448D" modified="2015-06-24" version="1">MGTTSVRRGVLAAAAVSLCLLATACDSGGSAAAGGGSGEVRTEAAPGGTAKSAAALTRMLVAPADLPEYTVEEKFRKTGPEQKAETDKAACEPLVRAQARMPLGKVGGTAGVAVLGKPEPAPADASEDEKLDALRQSAGRKGTTVFLDSYAGKGAEEAFAAVKGAVTACAGGYTAFGGPKAVRVEQVLPVPQDPAGDESLAFRLVLGMGDGQKTNVQFVFVRKGDVLATFEVLSLLGDAPQPPKAVVEAQSKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1G4</accession>
    <name>A0A0F4I1G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl-synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001866">
        <property type="protein sequence ID" value="KJY15777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15777">
        <property type="protein sequence ID" value="KJY15777"/>
        <property type="gene ID" value="VR44_40840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="6784" checksum="B36C8E0F2BC1D9F7" modified="2015-06-24" version="1" fragment="single">DGASNGLTAPSGRAQQLVIRQALANAGLTTADVDAVEGHGTGTRLGDPIEASALLATYGRERGAGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I313</accession>
    <name>A0A0F4I313_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001832">
        <property type="protein sequence ID" value="KJY15858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15858">
        <property type="protein sequence ID" value="KJY15858"/>
        <property type="gene ID" value="VR44_40735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7116"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7167" checksum="DC0721B92DDC32EC" modified="2015-06-24" version="1" fragment="single">LEHRAVVVGRDRETLVRGLTALASGEPSPSVVTGRATGRGRLAVLFTGQGSQRPGMGRELYGTFPVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4I3</accession>
    <name>A0A0F4I4I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001735">
        <property type="protein sequence ID" value="KJY16584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16584">
        <property type="protein sequence ID" value="KJY16584"/>
        <property type="gene ID" value="VR44_40375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6665"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="22707" checksum="45E74E0FB01106A9" modified="2015-06-24" version="1" fragment="single">RLPVPATAEQPLRVTRLSAARGARPGRLLLDTLTATTPPTGPAAPGTARPDPVVGTAAQAAARPWRFAVGGAPAGGGAELVLTGTERAPFLHRGVRFVPLDTGRRTLDRGAGLARMRALGQALEAAAREPGTAALAVVLPYAPDTLDRKETALLALRLAEFRRTTGKKAAVLTVGAPRFTAGRQEGVLTVAAPRTGRTLFGADAFAAPGRDWLSVAPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I693</accession>
    <name>A0A0F4I693_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001684">
        <property type="protein sequence ID" value="KJY17219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952628.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001684.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17219">
        <property type="protein sequence ID" value="KJY17219"/>
        <property type="gene ID" value="VR44_40100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6392"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="17727" checksum="EA68ECC33968256B" modified="2015-06-24" version="1">MPRWTHYRFRSVWDLDAPPALVYSLLEDPRHYPGWWPQVRRVAQTGGRSGTAVIRSVLPYEIHVTLTSLLRDPARGVLEVALGGDLDGWARWTVRPRGGPAARRTRAVYEQEVEVRAPLLRRFALAGRPALRLNHALMMRAGRHGLAARLTTPPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7K3</accession>
    <name>A0A0F4I7K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001658">
        <property type="protein sequence ID" value="KJY17644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17644">
        <property type="protein sequence ID" value="KJY17644"/>
        <property type="gene ID" value="VR44_39895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6284"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6612" checksum="998ABEBB39250C95" modified="2015-06-24" version="1" fragment="single">TGTLTRPQLLVLGRHDQHGRLRAVGRAVPLRPDISRQVGEHLAAAGPGHPLRGGAVRLGLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9Y1</accession>
    <name>A0A0F4I9Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001579">
        <property type="protein sequence ID" value="KJY18875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952494.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001579.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18875">
        <property type="protein sequence ID" value="KJY18875"/>
        <property type="gene ID" value="VR44_39350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5672"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29714" checksum="1ED11E501C10AFD8" modified="2015-06-24" version="1">MLLDTASLYFRAYFGVPESVKAPDGTPVNAVRGLLDFIGRLVQDHHPDDLVACMDADWRPHWRVELIPSYKAHRVAEPSESGPDLEEVPDTLAPQVPIIEAALDAFGIARVGVAGYEADDVIGTLTARATGPVDIVTGDRDLYQLVDDARARRVLYPLKGVGTLQVTDEAWLREKYGVDGPGYADLALLRGDPSDGLPGVPGIGEKTAAKLLDAYGSLAGIIAAVDDPKSKLTPTQRKRLDESRPYLAARPEMVDALAHRWGLGGAMSRLSSALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IER3</accession>
    <name>A0A0F4IER3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001499">
        <property type="protein sequence ID" value="KJY20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20487">
        <property type="protein sequence ID" value="KJY20487"/>
        <property type="gene ID" value="VR44_38655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5406"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="29172" checksum="33CE4C811FD7B2BC" modified="2015-06-24" version="1">MVVAGVAFGMNRMGTVVRGDAEQGRYVQDTALADGAAAAALEKLTEEPPPVRVLAEEPWKASDPLEARDVPAEPAIGALFSPGLDWDDDHHCSGSVVHSAGGDLVVTAAHCVYAGGFRNNLAFVPGYEEGKAPYGVWVPTRIDVDPRWVRDSDPDADVAFIRVRRAGHPGQRLEDVTGAHPIRFGQQLPVPARLVGYPNDTERPLGCSNTAVADGPTQLRLDCADVPNGTSGGPVLTSGNSLIGVIGGRDGGGDETTSFSSYFGDGVRALYERAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKT4</accession>
    <name>A0A0F4IKT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_37840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001414">
        <property type="protein sequence ID" value="KJY22607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952209.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22607">
        <property type="protein sequence ID" value="KJY22607"/>
        <property type="gene ID" value="VR44_37840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5127"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY22607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="32240" checksum="68262182841B1FAF" modified="2015-06-24" version="1">MGGAAALEKLVPVLLAFGGGVLLARRKTVPAEASKAFSDYAFLFAVPCYLFGNIYAADLGALFDWRAIGGYAAAAALAVLAVVLGAAACGIREPRAVALRVMAGVQVNTAYFAVPVFITFFGTAAPIFPVLLFQVCVLSLVVIALMELGRAGDGGPGTRLSRALAASLATPLVLACNAGILLNLLSVHVPKVLLDGAAFVGDSASPVALFALGLHLGGAGLGVRDTTREEAALIAFKCLAFPLLAWAVCAGLFGVRGPWLAYLVLIAAMPTPQNLFIFAQRYDIGVDLSASVVVKSSVVSLLLLPLWLQTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP31</accession>
    <name>A0A0F4IP31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-butyrolactone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001363">
        <property type="protein sequence ID" value="KJY23782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952104.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001363.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23782">
        <property type="protein sequence ID" value="KJY23782"/>
        <property type="gene ID" value="VR44_37275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4847"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="24020" checksum="3BD1C0E81DD619D1" modified="2015-06-24" version="1">MAEQVRAIRTRQAILSAAAKIFEERGYQASTISEILTVAGVTKGALYFHFQSKDDLAQGVLNAQNQNLVLPERAAKLQEIVDIVMLHTYRLQTDPMVRAGVRLTMDQMAGDLDRSGPFRNWAVPVRERLEKAQAQGELLPHVIPAETADVIVGSYAGIQSMSQALTDYEDLTTRASALLRHLMPSIAQPSVLASLHMGEDRAAEVFHEASAALVTDEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP40</accession>
    <name>A0A0F4IP40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_37245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001360">
        <property type="protein sequence ID" value="KJY23792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23792">
        <property type="protein sequence ID" value="KJY23792"/>
        <property type="gene ID" value="VR44_37245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4840"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY23792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="456" mass="46851" checksum="01C2C1C4152B69AC" modified="2015-06-24" version="1">MSSPRTLPHPVDQSRPLSRILLFGVQHVLVMAATPVSAIFLMSATLHLGPRLTVNLLSAAFVLSGIGSLIQSLGPWKFGPRLPFVMLPGGAPLILFLAIADEHGVRTATGAVIISAAFTFLVLPVFSRLLKYFPTLVIGTMIVIVGVNLVKVGALLVTGRPGQPGFADPANLALGLATIGFTVALYWLFSGVLRQLAVMLGLIAGSVLAFALGRIDFGGVTGGGILSAPQLMPFGTPEFHLVAALPLMLYALASMAEATGQTVINAETVGKEIDARTAVPRTVRGDALVSVLAGFLGLPLMVTSGENIGIVRVTGVRSRFVTAAAGAVLIAIGFLTPVIRAISVIPSAVVGGTAMVVFAVITVLGVQMLGKAELDRHSHAFICAVALALGLLPILVPGVYAGLPSGARILLESGVAVGACTAAVLNVLFHHVRPRLAARTALAPAEAAGPAPLPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPA4</accession>
    <name>A0A0F4IPA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001345">
        <property type="protein sequence ID" value="KJY23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23862">
        <property type="protein sequence ID" value="KJY23862"/>
        <property type="gene ID" value="VR44_37050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4797"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21152" checksum="4EFEF00A898BF55E" modified="2015-06-24" version="1">MTASATLRDLSGLENRPPRLAESVLILIDFQNTYRTGVMALDGAEEAVAAAARLLARARAAGTPVVHVVHDGGEGSPYDVREHIGSLSDEVAPADGEPVVVKNFPNAFHATDLEKTLTGLGFAAGSGKDLVLAGFMTHMCITFTAQQAFNLGYRPTVVAEATATRALAAPDGTVLPAAALQNAALTTITDLFGVVVPTADDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPD6</accession>
    <name>A0A0F4IPD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001336">
        <property type="protein sequence ID" value="KJY23900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23900">
        <property type="protein sequence ID" value="KJY23900"/>
        <property type="gene ID" value="VR44_36935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="58" mass="6552" checksum="BA17A83BCCEBDBF9" modified="2015-06-24" version="1" fragment="single">MNARRHEEELLGPYVLGVLDEEDVRRVEEHVGDCTGCREEVAALREMESVLGEVPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQG2</accession>
    <name>A0A0F4IQG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_36895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001334">
        <property type="protein sequence ID" value="KJY23909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23909">
        <property type="protein sequence ID" value="KJY23909"/>
        <property type="gene ID" value="VR44_36895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4694"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="223"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY23909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="516" mass="54538" checksum="F3B79851274838B3" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR39</accession>
    <name>A0A0F4IR39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001326">
        <property type="protein sequence ID" value="KJY23938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23938">
        <property type="protein sequence ID" value="KJY23938"/>
        <property type="gene ID" value="VR44_36790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4670"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13838" checksum="2061F9CE946250F9" modified="2015-06-24" version="1" fragment="single">MRFLFVHGTGVRRDRHDTLFALVRERLADRFPGAAVDSCFWGERFGAALGSGGRSVPGLRTAADTDAADTETAEWGLLLADPLCELRVLAEAGWDTGGPGHTDGHDAADDPFAMPGARPAGTRVLGLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR42</accession>
    <name>A0A0F4IR42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001219">
        <property type="protein sequence ID" value="KJY24490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951721.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24490">
        <property type="protein sequence ID" value="KJY24490"/>
        <property type="gene ID" value="VR44_35220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4125"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="288"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="41322" checksum="8658328E0CEF5632" modified="2015-06-24" version="1">MGTRAERLEWTRGDGLVAVGAAATDLTGLSLSAVVDGTPFTVTGALGLVLAALTLLFRRHHPLPVLGAVLTLGLVVNVATPAAPHFGLTLTVALFTVGRRCRPAAVAAAGLATVPLAAVGLGGSLIPSGLNVLTNAVAAALVVGAAVAANRWQREVEANRQLLAERAVAEERRRIARELHDIVAHHITTMQLMAGGARVSLEHDPGAAREALVTLEASGRMALGEMRQLLDVLRAGEEAESAPPAPQPGTADLQRIVTESRLAGMDTEFTVHGTVRPLPPTVGLTVFRVVQEALTNARKHAGNANARVRLTYRPQEVSVEVCDDGPGDGPPRRTPARPRSGRAGYGLIGMRERVALHGGTLEAAPREDGGFRVAARLPVPAAAGAPDGAEREDHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRW5</accession>
    <name>A0A0F4IRW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001172">
        <property type="protein sequence ID" value="KJY24760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951562.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001172.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24760">
        <property type="protein sequence ID" value="KJY24760"/>
        <property type="gene ID" value="VR44_34365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3851"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="31457" checksum="584C9270239E137C" modified="2015-06-24" version="1">MAGKGTGRDKGRNRDGGRRGSAEPVTGQVGGGLAELTPDRERARAWTLLIDGAPQSHVDLDDPGYLDFAYQRRIGHLIDLAAPARQPLNVVHLGGGALTLARYTAAARPRSAQQVVEVDSALVAFVREHLPLDPQARIRVRAVDARAGLAKVPDGWADLVIADVFSGARTPAHLTSAEFLDDVRRALSPTGWYVANLADGPPLAHLRAQVATAASRFERLALAADPVVWRGKRFGNAVLVASDQELPVAEFTRRVASDPHPGRVEHGRALTDFTGGAAPVSDASATASPPPPASVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISA7</accession>
    <name>A0A0F4ISA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_34000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001150">
        <property type="protein sequence ID" value="KJY24905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951497.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001150.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24905">
        <property type="protein sequence ID" value="KJY24905"/>
        <property type="gene ID" value="VR44_34000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3725"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23004" checksum="EC0B7D87F1907B28" modified="2015-06-24" version="1">MRADWSTFWPKVLDATGETVYMVLITLALSTVGGLSVGLALYATRKGGVLPNRAVHAVLGTFINVIRPVPFIIAIVALAPVTRAVVGTMIGTDAAVFPMTVVATFGIARIVESNLLSVEPGVIEAARSMGAGPLRILLTVLVPEALGPLVLGLTFMLVALIDFSAVAGTVGGGGVGNLAMTYGYLRFDTSVMVVTVLVLIALVQSAQFLGNLLSRRILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISC2</accession>
    <name>A0A0F4ISC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001236">
        <property type="protein sequence ID" value="KJY24383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951782.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001236.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24383">
        <property type="protein sequence ID" value="KJY24383"/>
        <property type="gene ID" value="VR44_35545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4222"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="140"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="38101" checksum="F3A1FFB17D87C99D" modified="2015-06-24" version="1">MRVALIGYGLAGSVFHAPLVSATEGLVLDTVVTSDPGRQAQAREEYPGVRIAASADELWERAADADGENRLGLVVIASPNKTHVPLATAALTAGLPVVVDKPLAATAAEARELAALAERTGTFLSVFQNRRWDNDFLTVRRLLADGELGEIQRFESRYERWRPQLKGGWRESGAPEEIGGLLYDLGSHVVDQALVLFGPAVRVYAETDVRRPGAEADDDTFIAITHANGVRSHLYVSATAAQLGPRFRVLGSRAGYVKYGLDPQEAALREGLRPGGADGPAWGEEPEHMWGRLGSGESPLTGGGVPVPTVPGDYPAYYAAVAEALRTGGPAPVTADEAAHTLAVLEAARLSSRKGSVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISM3</accession>
    <name>A0A0F4ISM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001189">
        <property type="protein sequence ID" value="KJY24654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24654">
        <property type="protein sequence ID" value="KJY24654"/>
        <property type="gene ID" value="VR44_34720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4009"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="22271" checksum="8B4DCB203A3D6D2F" modified="2015-06-24" version="1" fragment="single">MAGAGRGPAAPAARAVGPCAGGEGRTVNVLAVAVWAAVLLSSLGLLLGPRRARVPGTPEAHDLSEAAFLAGGPGTVVDAALVALLGDGRLVAGGPGIVHEGRRARGADPAERAVLSALRAAPSGWLYQVRYAAMLDPAVQEVGDALAARGMVSPPGSGRGRRRWGLVQAVVCAALIPVSLPVTFVAMALTREAQVPFVLEVLPVLVGGIVAGAWGARRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISZ6</accession>
    <name>A0A0F4ISZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001351">
        <property type="protein sequence ID" value="KJY23831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952079.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23831">
        <property type="protein sequence ID" value="KJY23831"/>
        <property type="gene ID" value="VR44_37135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4816"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="17400" checksum="EAF14EB0D9F22B0D" modified="2015-06-24" version="1">MTESLDPTDWAILDEVQRDGRIPFTELARRVSLSASATTERVRRLEALGVITGYRAEVDLERTGHAVLAVVRLKYPGTRHEPLHRLLAERPEILECLRTTGDDCYVLRVAATSMGHLEEVVDALAGFGSTTTNLVFSRTLPLRGPRAPRRAADGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT01</accession>
    <name>A0A0F4IT01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000072_gene295"/>
    <dbReference type="EnsemblBacteria" id="KJY25122">
        <property type="protein sequence ID" value="KJY25122"/>
        <property type="gene ID" value="VR44_33380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3554"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25754" checksum="1A6C1635C05A9C80" modified="2015-06-24" version="1" fragment="single">ETGMLPRRYMHEYGATRDHLFNVAMACRNRANENPAAMMYERPLTREMYMTSRMISDPLCLFDNCLETDGALACVIVSAERARDCRQKPVYVHSAAQGLPAQHHGMVNYWNDDPLSGPAWTAARHLWKQADFGPADVDVAQIYDAFTPLIPLSLEGYGFCGRGEGAAFTEGGALEMGGRLPINTGGGGLSEAYVHGFNLINEGVKQLRGTSTAQVPDAATCLVTAGEGVPTSAILLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITB9</accession>
    <name>A0A0F4ITB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_32985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001100">
        <property type="protein sequence ID" value="KJY25260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951308.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001100.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3202"/>
    <dbReference type="EnsemblBacteria" id="KJY25260">
        <property type="protein sequence ID" value="KJY25260"/>
        <property type="gene ID" value="VR44_32985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3417"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="26687" checksum="AC06BB88B5EC7F47" modified="2015-06-24" version="1">MSSSDIFIGETIGTALLTLLGGGVCAALTLKSSKARGAGWLAITFGWGFAVLIAAYVSAPLSGAHLNPAVTVGIAVKTGEWGDVPVYLAGQLLGAMIGAVLMWITYYGQFRAHLADPENIKDARLGPEDPHPHDVAGPVLGIFSTGPEIRNVVQNMATEIIGTFVLVLAILTQGLQDDGKGLGVIGVLITSFVVVGIGLSLGGPTGYAINPVRDLGPRIVHALLPLPNKGGSDWGYSWIPVAGPLVGALLAGGLYNIAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITH0</accession>
    <name>A0A0F4ITH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001146">
        <property type="protein sequence ID" value="KJY24929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951482.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001146.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7087"/>
    <dbReference type="EnsemblBacteria" id="KJY24929">
        <property type="protein sequence ID" value="KJY24929"/>
        <property type="gene ID" value="VR44_33915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3709"/>
    <dbReference type="eggNOG" id="COG2902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1654" mass="182942" checksum="4D6A29C69104C318" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITJ2</accession>
    <name>A0A0F4ITJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001314">
        <property type="protein sequence ID" value="KJY23996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951982.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001314.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23996">
        <property type="protein sequence ID" value="KJY23996"/>
        <property type="gene ID" value="VR44_36610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4630"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="446" mass="48066" checksum="AE84AEDD3295E6BC" modified="2015-06-24" version="1" fragment="single">GVDEDVVHRHRRAVTPDAVATVIYTSGTTGRPKGCVLTHANFMFEADTLVSRWKSVFQAGPEEQPSTLLFLPLAHVFGRMVEVAAVRARVKLGHQPALAASELLPDLAAFRPTFVLGVPYVFEKVFAAARRGAEAEGRTGPFDRAVETAVRYAEAREQKAFGTGPGPSAALRMEHQLFEKLVYGKVREALGGRVRYAMSGGSAMARRLGLFFDGAGITVFEGYGLTESCAAATANPPGAVKYGTVGPPIPGTTVHIAEDGEVWLYGRHVFSGYLGDARATEEVLREGWLATGDLGRLDGDGYLTITGRKKEILVTSNGKSVAPAALEERVRSHPLVSQCVLVGNDRPFITALVTLDMEGIAHWLSMRGLAQRSAEQLVGDPALTAEVRRAVVAANTLVSQAEQIRAFRVLAGQFTEERGLLTPSLKLKRRAIEKAYAREIAALYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITR4</accession>
    <name>A0A0F4ITR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001132">
        <property type="protein sequence ID" value="KJY25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951433.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001132.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25024">
        <property type="protein sequence ID" value="KJY25024"/>
        <property type="gene ID" value="VR44_33645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3639"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="41909" checksum="4621FDA18418C3DB" modified="2015-06-24" version="1">MPVEFLGIAATNDGSETTARSGAAFDKDYTLRLARAHEDHGWDRVLFAYGSGSPDPAPAAAYVAARLDRLQLLLAHRPNVSYPTYAAKTFATLDQISEGRLTVHFITGGNDHEQGREGDTLTKDERYARTREYIQIVKKVWTTREPFDHEGEHYRFHDFVSDVFPVRRPRPDVSFGGSSPAAYAAGGAEADIYCLWGEPLEETAQQIEAVKAAARAAGRTDVPRIQVAFRPIIAPTEELAWEKAHRTLGAIRRRREAAPARHVRGGVTQTSAPQNTGSQRLIAIAEAGERYDRALWTPTAAATGGAGNSNALVGTPETVAQALLDYHDLGVDILSARGYDLLDDAVDFGRHVIPLVREEVAKRDAARAAAHPVSEPRQSAAAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITS2</accession>
    <name>A0A0F4ITS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001297">
        <property type="protein sequence ID" value="KJY24081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951936.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001297.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene289"/>
    <dbReference type="EnsemblBacteria" id="KJY24081">
        <property type="protein sequence ID" value="KJY24081"/>
        <property type="gene ID" value="VR44_36370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4526"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27992" checksum="DB605DE8E2D8E18F" modified="2015-06-24" version="1">MRIARFSIDGNVAFGAVEGSTAPGAEGELVLDIIKGIPFADFELSGTKVPLSKVRLLPPVLPNKVVAVGRNYAEHAAELGNELPEAPITFFKPSTSVVGSGDPIVYPSFSQDVHHEAELAVVIGRMCREVPKERVKDVILGYTCANDVTARDVQQREKQWARAKGFDSACPLGPWIETDLDPADLTIQCTVNGEQRQLGRTSDMVRSVEDLVVHISEAMTLLPGDVILTGTPAGVGPLNVGDEVAVTIEGIGTLTNKVIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU45</accession>
    <name>A0A0F4IU45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001269">
        <property type="protein sequence ID" value="KJY24211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951869.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001269.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5586"/>
    <dbReference type="EnsemblBacteria" id="KJY24211">
        <property type="protein sequence ID" value="KJY24211"/>
        <property type="gene ID" value="VR44_36015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4361"/>
    <dbReference type="eggNOG" id="COG1875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="48030" checksum="370F7EFEB6636576" modified="2015-06-24" version="1">MVTSTKRRLSDRRTYVLDTSVLLADPNAISRFDEHEVVLPIVVITELEAKRHHPELGYFARQALRLLDDFRVRHGRLDAPIPLGDLGGTLRVELNHSDTAALPAGFRQGDNDSRILAVARNLQAEGYDVTVVSKDLPLRIKASSVGLLAEEYRAELAITDAGWTGMSELALSGEQVDLLYSEERLYVPEAAELPVHTGLILQSERGKALGRVTADGNVRLVRGDRDAFGLHGRSAEQRIALDLLLDPEIGIISMGGRAGTGKSALALCAGLEAVLERRQHQKVMVFRPLYAVGGQELGYLPGDQSEKMSPWAQAVFDTLSSVAGREVIEEVLNRGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGANSRVVLTHDVAQRDNLRVGRYDGVVAVVEKLKGHPLFAHVTLTRSERSPIAALVTEMLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVN4</accession>
    <name>A0A0F4IVN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein in whiE locus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001033">
        <property type="protein sequence ID" value="KJY25699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951097.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25699">
        <property type="protein sequence ID" value="KJY25699"/>
        <property type="gene ID" value="VR44_31835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3079"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016672">
        <property type="entry name" value="Polyketide_Synth_CurC_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016602">
        <property type="entry name" value="CurC_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16125" checksum="E896A76CF5359B46" modified="2015-06-24" version="1">MTKHHPRIVDLSETQPNRRRGGDLRAVLTPTSVGSTSGFMGLAVMAPGESIAEHYHPYSEEFVYVVAGTLEVDLDGETHPLRTDQGLLVPLNVRHRFRNVGSSEARMVFHLGPLAPDPKLGHVDTEEAPNPDATAWAERPPERTGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVV6</accession>
    <name>A0A0F4IVV6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001163">
        <property type="protein sequence ID" value="KJY24826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24826">
        <property type="protein sequence ID" value="KJY24826"/>
        <property type="gene ID" value="VR44_34195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3810"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="367" mass="38674" checksum="0E1F99A76813A0E1" modified="2015-06-24" version="1" fragment="single">PSADAARGDGAGRIAPRDTTELRMARLWEQTLGTAPIGVRDDFFALGGHSLKAFALMAAVRREFGVELPLNLVFRRRTVELLCEALPDAGAAAARLLVPLADGDPSRPPLVLVHPRGGDVVCYRDLVRDLSALPGGDRRILGLESVGYNTEERPLETVPEMAERYLAALREEQPHGPYLLAGWSFGGTVAYEMAARLEAAGEEVAFLGLIDTAAPGAAPGNRAGTDAGPGDPDLLRYGIAAGVDADSARELDEEELLDVLVRRGRAEGTLPRTAPTEALRRVLRVAEANGAASAGYRTDAVLAVGLHLFTVDERHPELATPLVDPAAWHARTAGGVLRAAVPGNHHDLVDPPHCAALAGLLAAALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW32</accession>
    <name>A0A0F4IW32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001038">
        <property type="protein sequence ID" value="KJY25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951107.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25663">
        <property type="protein sequence ID" value="KJY25663"/>
        <property type="gene ID" value="VR44_31880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3090"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22241" checksum="5521AE7A767D1C97" modified="2015-06-24" version="1" fragment="single">GRSGGAPGALACAALLPERVTRTAALVPIAPRDAEDLDWFAGMAASNVREYTTAAADPEELTARLIPRASGIARDPGRLLDELRRELTASDRMIVSDAGLRSMLLRNYREGVRTSAFGWIDDMLAASSPWGFDPADIRCPVLIWHGELDVFSPVGHARWLGRRIPGATTTIDPDAAHFAALRALPGVLTWLLRELPAPSVEEQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWG3</accession>
    <name>A0A0F4IWG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000945">
        <property type="protein sequence ID" value="KJY26390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950794.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000945.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26390">
        <property type="protein sequence ID" value="KJY26390"/>
        <property type="gene ID" value="VR44_30175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2440"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045991">
        <property type="entry name" value="DUF5947"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19372">
        <property type="entry name" value="DUF5947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22910" checksum="72B987EAAAA6F453" modified="2015-06-24" version="1">MTGPRPRGLRRFTGPRPPRPESCELCGTPVPPDGHRHLVETEKRALVCACTACALLFDRPGARTGRYRAVPDRYLADPGHELDDAAWERLRIPVGVAFLFRNAALGRLVALYPSPAGATESELDPDTWQSVLGAGRLAGLLEPDVEALLLHHTPGHTTCHLVPIDLCYELVGRMRLSWRGFDGGAEARAALDALFARVEARARILAEAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWH8</accession>
    <name>A0A0F4IWH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000943">
        <property type="protein sequence ID" value="KJY26405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950785.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000943.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26405">
        <property type="protein sequence ID" value="KJY26405"/>
        <property type="gene ID" value="VR44_30125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2429"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10875" checksum="DC37E75646551A41" modified="2015-06-24" version="1">MTHAEEWRVDLYLVEEDGTTRARAVLDNGKTTITGSGRARCNPQDVDVPAIGEELAAGRAMRDLSARLMRAADRDLAAVGAVPEPPRTGYGWPDDARPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX61</accession>
    <name>A0A0F4IX61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000915">
        <property type="protein sequence ID" value="KJY26630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950686.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000915.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26630">
        <property type="protein sequence ID" value="KJY26630"/>
        <property type="gene ID" value="VR44_29580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2294"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="34108" checksum="0CE160A8A4EA6617" modified="2015-06-24" version="1">MKAVVISAHGGPEVLTLTELPDPVPTDGEVLIRVKAFGLNHAEAYMRSGAWGEVAAVPGIECAGVVEADPSGRLPSGTRVVAILGGMGRTRNGSYAELVTVPATNVVAVHSPLGWGDLAAVPEVYATAWSGLFDNLDLRPGETVLVRGATSSLGQAAVNLAVDHGATVLATTRNPAHVPLLKELGADDALIDDGALAVQVGERGIAVDAVFDVVGNKVLRDSLATVRPRGRVCQLGFLGGFEPVRDFDPIGDLPSGVRFSFFGSAFVLGTPAFPLADVPLHQIYDKIGAGMLRARPVRVFRFDEIVEAHRIMEAGEALGKMVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYC3</accession>
    <name>A0A0F4IYC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000879">
        <property type="protein sequence ID" value="KJY26997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26997">
        <property type="protein sequence ID" value="KJY26997"/>
        <property type="gene ID" value="VR44_28625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2054"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469945" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="39"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="125"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="25491" checksum="D16333CEE1B24E91" modified="2015-06-24" version="1">MAGIRVRVRAGRRAAVVFGGALALAAPLVVAGGGAAQAAEAAASCNVTTGPYQRQVEQFLGRPVDGVQSAADCAAIQSFQATHGITPTMGYAGPLTWQTMSTMLAQRAAGKNPNAAGQCPTNLGRIACVDLTRQLSWIQDGATLKYGPVPVRTGKAETPTRTGLKKIYYRNINHWSTIYNVAMPYAQFFDGGIAFHSVEKSMWNPPGSGGCVNMTTADAKAYWNMLTNGEDVFVYGRKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZJ2</accession>
    <name>A0A0F4IZJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000887">
        <property type="protein sequence ID" value="KJY26913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26913">
        <property type="protein sequence ID" value="KJY26913"/>
        <property type="gene ID" value="VR44_28905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2121"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="19876" checksum="0CF666705B145D9E" modified="2015-06-24" version="1" fragment="single">MGARGVAQPVHPVGEVFPLLGGVLAARPVHQQVAEVRRLVGGREPVVGGGQFREEDVHRALVGDRVVQHGDQAAVTVPALRVQHPRGSGRQGPAAPRGQGALHHAGLQRWLHPFGDRLEGAGPVAEEGGAQGLVPLDDQVEGIAQPGRVETARDAHRGDDVVGAQPRVELLHQPQPALPAGDGRAGRVGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZT1</accession>
    <name>A0A0F4IZT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000864">
        <property type="protein sequence ID" value="KJY27164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5086"/>
    <dbReference type="EnsemblBacteria" id="KJY27164">
        <property type="protein sequence ID" value="KJY27164"/>
        <property type="gene ID" value="VR44_28330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="11064" checksum="50C882A2B00BCB7A" modified="2015-06-24" version="1" fragment="single">MPVSVTLPALGESVTEGTVTRWLKAEGERVEADEPLLEVSTDKVDTEIPSPVSGILASIKVAEDETVEVGAELAIIDDGSGAAAPAAAPAAEPAAAPAPVAEAPAAPAPAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0K0</accession>
    <name>A0A0F4J0K0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000796">
        <property type="protein sequence ID" value="KJY27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950169.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000796.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3185"/>
    <dbReference type="EnsemblBacteria" id="KJY27805">
        <property type="protein sequence ID" value="KJY27805"/>
        <property type="gene ID" value="VR44_26740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1507"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="206"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="446" mass="48013" checksum="139E102497B7A33C" modified="2015-06-24" version="1">MGGSSVSAAGAGKTVSGQDEVVDLCRDLIRIDTSNYGDHSGPGERKAAEWVAEKLAEVGLEPQIFESHKGRASTVARIEGEDPSRPALLIHGHTDVVPANAADWTYDPFSGEIADGCVWGRGAVDMKDMDAMTLAVVRDRMRSGRKPPRDIVLAFLADEEAGGTYGARHLVDKHPGLFEGVTEAIGEVGGFSFTVNENLRLYLVETAQKGMHWMRLTVEGTAGHGSMTNTDNAITELCEAVGRLGRHTWPVRVTKTVRHFLDELSDALGTPLDPDDMDATLAKLGGIAKMVGATLRNSAAPTMLGAGYKVNVIPGQATAHVDGRFLPGYEDEFFADLDRILGPRVKREDVHADKALETDFDGKLVDAMQGALRAEDPIARAVPYMLSGGTDAKSFDDLGIRCFGFAPLQLPPELDFAGMFHGVDERVPVDGLKFGVRVLDRFIDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J115</accession>
    <name>A0A0F4J115_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_27270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000819">
        <property type="protein sequence ID" value="KJY27569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27569">
        <property type="protein sequence ID" value="KJY27569"/>
        <property type="gene ID" value="VR44_27270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1590"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="131"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="601" mass="60779" checksum="CB863CE4E2D3E218" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J128</accession>
    <name>A0A0F4J128_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000915">
        <property type="protein sequence ID" value="KJY26631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950687.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000915.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26631">
        <property type="protein sequence ID" value="KJY26631"/>
        <property type="gene ID" value="VR44_29585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2295"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20954" checksum="2D1D1B6779A80B54" modified="2015-06-24" version="1">MPRPREFEPDTVLNAAMLRFWERGYRATSIEDLVKATGVKPGSLYSAFPGGKRTLFLKSLERYSRLVVPQKLGELEASGASVAEIRGYFDGLVRDLLSPEGRQGCLLVNTAIEKAAEDDEAAAVVRGHLARLERCMTHALENAVRRGQVRAGLDCAGSARLLVATCQGLMVVGKANPDEALLRAIVDNAFAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1S1</accession>
    <name>A0A0F4J1S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000751">
        <property type="protein sequence ID" value="KJY28230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950002.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000751.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28230">
        <property type="protein sequence ID" value="KJY28230"/>
        <property type="gene ID" value="VR44_25870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1279"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8855" checksum="4BDA477235109CE8" modified="2015-06-24" version="1">MGDRQHGEGQDRGRAPEKGEGRRIRGRSPSPEQLRTGGRPRTPDEITHERGREDATMRDVMRDLREEDLDDMRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J240</accession>
    <name>A0A0F4J240_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_28725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000881">
        <property type="protein sequence ID" value="KJY26971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950529.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000881.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26971">
        <property type="protein sequence ID" value="KJY26971"/>
        <property type="gene ID" value="VR44_28725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2077"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="26442" checksum="EBB8F6658E41859E" modified="2015-06-24" version="1">MNTLHSTTTSAVVTRLHDANRRAGVRTVPGSRRQARVVAIDANQYQAVPAQRTPSSSSPSSSSEAEFTAYVQERRAALYATAFHLTGDRHEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETASDTDAMRGTELRAVLWQALARIPEPQRTMLVLRYYEGRTDPEIAEILGISVGTVKSSIWRSLRRLREDEVLSFGRDEAESFGELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J245</accession>
    <name>A0A0F4J245_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813038.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3620"/>
    <dbReference type="EnsemblBacteria" id="KJY28330">
        <property type="protein sequence ID" value="KJY28330"/>
        <property type="gene ID" value="VR44_25560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1211"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014488">
        <property type="entry name" value="UCP017371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017371">
        <property type="entry name" value="UCP017371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15952" checksum="212C9A3F32DAB74A" modified="2015-06-24" version="1">MAQVEATTERIIGADAETVFDALADYTGTRGKLLPEHFSEYEVREGGDGEGTLVHWKLQATSKRVRDCLLEVTEPTDGQLVEKDRNSSMVTTWTVTPAGEGKSKAVVSTVWNGAGGIGGFFERTFAPKGLGRIYDTVLDNLAREVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2L2</accession>
    <name>A0A0F4J2L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000719">
        <property type="protein sequence ID" value="KJY28552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949852.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000719.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28552">
        <property type="protein sequence ID" value="KJY28552"/>
        <property type="gene ID" value="VR44_25055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1101"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12570" checksum="D51B49907C17FBCC" modified="2015-06-24" version="1">MTTRPAHVAVVVEPGPERVLAQVSGEIDMDQAPALRQELTAALAASRAGLDIDMAGVTFCDSSGLHALLDVDQLAMQAGKTLALTALRPPVARLLHMSGVERVLTVRAQVRWVKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J310</accession>
    <name>A0A0F4J310_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5959"/>
    <dbReference type="EnsemblBacteria" id="KJY28620">
        <property type="protein sequence ID" value="KJY28620"/>
        <property type="gene ID" value="VR44_24955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1079"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="28751" checksum="CBE42F28ACBF9D32" modified="2015-06-24" version="1">MVARLIDEDPEQAYAYSRIALRLASRVAAVREAAGFAAYATQKYSEALAEFRAAKRMTGSVELWPVMADCERGLGRPERALAMAGEPEVQKLDKAGQVEMRLVAAGARRDMGELDAAIVTLQSPELASNTVQPWTARLRYAYADALLAAGREDEAREWFAKTLEADKDGATDASDRLAEIDGVEFVDAAALEEDADLEDLGDEDDEDEDAAEVAAAERAADQTEYYDEDDEEYEPADDSVADVDLTDEIVVLGDDEREARDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J341</accession>
    <name>A0A0F4J341_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000711">
        <property type="protein sequence ID" value="KJY28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000711.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28655">
        <property type="protein sequence ID" value="KJY28655"/>
        <property type="gene ID" value="VR44_24885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.977"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="413" mass="41805" checksum="7C32F8B27EB1ADCC" modified="2015-06-24" version="1">MARRPTIKDIARQAGVSESAVSFALNGKPGVSEDTRARIRRVARELGWQPNSAARALSGERSGAVGLVLARPAHTLGAESFFLRLVSGIQEVLSAAGTALLLQVVEDVEAECAVYRRWWAERRVDGVLVVDPRTRDPRPALLSRLGLPAVVIGGGTGTPPDPWQPEGPARHGGAPAGGRDGAGGDTGAPGGTGTGAEGAAGYASGGGAGADGGAGAGGGAGDRAAAGTDGGPGPAVVRADDARAMTEVLDHLHGLGHRRIVHIAGLPGLAHTARRVAALRAEAARLGLPPGQVRSVPTDYSDTEGAAATRRVLAEPEPPTALVYVMAVAGSAVAAGLGIPVPGRLSIVAWDDSALCRVTHPPLTALVRDTAGFGRLAAEELLHLLAGGPPRVRESELPRLEPRGSTAPPPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Y7</accession>
    <name>A0A0F4J3Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949915.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000734.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28418">
        <property type="protein sequence ID" value="KJY28418"/>
        <property type="gene ID" value="VR44_25395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1175"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="474" mass="51418" checksum="C4A1E6AB50FB589B" modified="2015-06-24" version="1">MPSHLYADRSAQPPEPGSVDALISQTRRLRGEVDAVRRDTVVDDDDAQGRWQRALCDLAVHHLDDLGQHLGQLKEGLPPAPEHAELPPAPPETASEDRQTRVGSAEWNLLTDEVTWSEELFQIFGRSPEAGPLPLDELGSTLFSEDQPLLTAMVTDCLVDGKPIDGEFRIVRADGRVRTLHMRGEPVLDADGCTASMWAVLRDVSELRRSQRAERESRDSLQRRREIAQTEHRLAVELQEAVLPPWRGSLRFPHDDAAALDVAAHYLPSATSSLIGGDWYDALELPDGRSLLTVGDLTGHGVSATSGMAMLLGALRGMAMAGIEPGPLMGWLNQLLETSAQPALGSAVCCRYDPARRLLSWAQAGHPAPLLFRRGQGRALQPPEGVLLGATSGAVYGQAEELLELGDVLVLYTDGLTPHGVGFTRADQTERLLALAPRFSAARSARDCVRMVTEEFGESGREDDACVLVARVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4U6</accession>
    <name>A0A0F4J4U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_23355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949535.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene121"/>
    <dbReference type="EnsemblBacteria" id="KJY29275">
        <property type="protein sequence ID" value="KJY29275"/>
        <property type="gene ID" value="VR44_23355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.611"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="25772" checksum="8501DA688124B79F" modified="2015-06-24" version="1">MAETHVLFVEDDDVIREATTLALERDGFVVTAMPDGLSGLESFRANRPDIALLDVMVPGMDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGSVLVARIRAVLRRFGHAGGTQNGGNGPGAADDSDERGVLSFGDLEVDTEGMEVRRAGAPVALTPTEMRLLLEFSSAPGTVLSRDRLLERVWDYDWGGDTRVVDVHVQRLRTKIGQDRIETVRGFGYKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J533</accession>
    <name>A0A0F4J533_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29462">
        <property type="protein sequence ID" value="KJY29462"/>
        <property type="gene ID" value="VR44_22925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="8744" checksum="9B1E420659A72A38" modified="2015-06-24" version="1" fragment="single">MSAGADAAVVGTGPNGLAAAVTLARAGLRVVLYEQAGRIGGGLRTEALFDSDVRHDICSAVHPMAAASPFFRAFDLPGRGVPLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Z9</accession>
    <name>A0A0F4J5Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">VR44_23385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000659">
        <property type="protein sequence ID" value="KJY29259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949542.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000659.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5180"/>
    <dbReference type="EnsemblBacteria" id="KJY29259">
        <property type="protein sequence ID" value="KJY29259"/>
        <property type="gene ID" value="VR44_23385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.618"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="171"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="393"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="468"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="468"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY29259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="564" mass="58302" checksum="99A2FCA4E06EC15A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J668</accession>
    <name>A0A0F4J668_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000624">
        <property type="protein sequence ID" value="KJY29690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29690">
        <property type="protein sequence ID" value="KJY29690"/>
        <property type="gene ID" value="VR44_22315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.350"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="41057" checksum="4207CC6D956C7820" modified="2015-06-24" version="1">MPALPEQAQPSAPAARNRLYVLDGLRILAALLVLVHHYTRQELWGRDPFGWLTVVGRYSWMGVELFFMISGFVICMSAWGRPLGSYLRSRVVRLAPAYWFCVLLTMGVLLAFGKPFGGAGPALSQILTNLTMVQTPLGAAPLDASYWTLWSEIRFYLIFAVVAWSGLTYRKVLNFCWIWTIASLLAPGSGLPVLDVLANPDYSPLFISGICFYLIRREGPRAGEPWALLFFSWLLMQRWLNDIVRWNTVKGDRLSWEMCLLVITLCYAVMAAVALGRLDRINWRWLSAAGAMSYPLYLLHQQAGLTMLRQWHRDVEPWTLLLSAMAVMLLVSWLIQRFVERPAARALKRFLERRPAAATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6H9</accession>
    <name>A0A0F4J6H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949201.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29957">
        <property type="protein sequence ID" value="KJY29957"/>
        <property type="gene ID" value="VR44_21540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.186"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046224">
        <property type="entry name" value="DUF6257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19771">
        <property type="entry name" value="DUF6257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="8082" checksum="C27280019D5010BD" modified="2015-06-24" version="1">MAKDPNFTAREIAQIGWYTARMAKRGIAGENVHIGDLTRKVDRIIDTARERTEREEREAAEAKNAKRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7G6</accession>
    <name>A0A0F4J7G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30130">
        <property type="protein sequence ID" value="KJY30130"/>
        <property type="gene ID" value="VR44_21115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8946"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470796" evidence="2">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="42525" checksum="83EAF80F1311F979" modified="2015-06-24" version="1">MAVTGTTLVLASPAPARAARPVLAPAPAPVPVAVRRSPAARLLGPYARLFTVPGARGFTAGNVLARLPMGMFGISAVMMIAGQRGSYALAGAVTATGMAATAVVAPWTARLVDRYGQARIAVPATVIAVLGSLSLILCVRAQAPAWTLFASYAATATTPNIGGMSRARWTHLLPGSAHHTAMSFEQAADELCFMLGPVLAAFLCTAVFPEAGTLTGAVLLLTGMLVFTAHRATEPPAGGAPEGGRGRSPLRALLPLLGLFLATGLVFGSMEVTSVAHLAALGLGGTSGPVLALQAAGSCVAGLLYGARRPRSLRTCLCLLAGAMALPWAAAATGSLVPLAAALLLAGMSTAPVMVTAMGLVQSRTPEGRLNEGMTLAVTAILAGIAAGSATAGLAVDHLGTGTAYLLPAAGGLAALIVGSAAPRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N3</accession>
    <name>A0A0F4J7N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000692">
        <property type="protein sequence ID" value="KJY28936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949674.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000692.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28936">
        <property type="protein sequence ID" value="KJY28936"/>
        <property type="gene ID" value="VR44_24100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.814"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="11806" checksum="8BACBB650323D68C" modified="2015-06-24" version="1" fragment="single">MYEPIRSKSAVHVVDGSHSAPQYPQSSRGEALDIQLAGHLAALLAVTDELGLEDGGAARIAEQVTRLRGSQPVRVSYPALSDGADTATLHRRAHDLAARALLVAASRADTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7T9</accession>
    <name>A0A0F4J7T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000611">
        <property type="protein sequence ID" value="KJY29833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949274.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000611.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29833">
        <property type="protein sequence ID" value="KJY29833"/>
        <property type="gene ID" value="VR44_21910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.262"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="21791" checksum="F42FCB93B68F63CA" modified="2015-06-24" version="1">MGGKYRVTGTAYPRMSRPRRRRKLVFALLGSVLALALLGYGALQLIDVFRGDSGKHNAAAKDCPTGAASATPAGAANPGPAASGAPAAVLPQPGQITVNVYNATPRAGLAKAVGDELKKRGFTIGHVGNAPADFDKKVPGPGILLGSPRTDKAAYSVLGAQLAGVTQQTDTREGADIDLILGDSFKELNKKEDADKALAVLANPAPAPSPKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Z7</accession>
    <name>A0A0F4J7Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000560">
        <property type="protein sequence ID" value="KJY30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948973.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000560.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30502">
        <property type="protein sequence ID" value="KJY30502"/>
        <property type="gene ID" value="VR44_20300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8769"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="20013" checksum="6DEB7FDBFB0704DB" modified="2015-06-24" version="1">MTTSRVDHRTEPSTTAGEREMLDGWLEYHRETLAWKCEGLSDEQLRATPLRPSALSLMGLVRHMAEVERYWFREIALGADLPDLYSTRDNRDGDFEFTDGDTWAQAREVWQEEVELARRAAAGRSLDAVSDAASHHRGEVFSLRWIYTHMIEEYARHNGHADLLREHLDGATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9X0</accession>
    <name>A0A0F4J9X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000552">
        <property type="protein sequence ID" value="KJY30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30599">
        <property type="protein sequence ID" value="KJY30599"/>
        <property type="gene ID" value="VR44_20015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8625"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470515" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="6882" checksum="025E868708D4EC36" modified="2015-06-24" version="1">MSHHVHTPSPAPARRRMFRYMMVMTSAAFIAGGIASLPASTGTGPHAAPAVTSGVGADAGRLIGIPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA52</accession>
    <name>A0A0F4JA52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_18985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948731.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31060">
        <property type="protein sequence ID" value="KJY31060"/>
        <property type="gene ID" value="VR44_18985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8401"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="54853" checksum="7E7B566962D6E27D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAG9</accession>
    <name>A0A0F4JAG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_18620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31190">
        <property type="protein sequence ID" value="KJY31190"/>
        <property type="gene ID" value="VR44_18620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="452" mass="46664" checksum="025549A827A3F4CC" modified="2015-06-24" version="1" fragment="single">MPAGRRRLALAVLVLAQLTVWLDNTILNVALKTLADPQEGLGASTNQLQWSISSYTLIFAVMLFSGGVLGDRYGHRRMLLTGTAVFAASSLWAGLSGGPGELITARGAMGVGSALIMPATLSLISAVFDARERAMAIAIWSGSSGLAIAAGPLVGGALLERFWWGSVFLVNLPLAAVTVLGAVFLLPAARSTSRTKLDPLGVLLSTVGLLAVVYGLIEGGHRNEWTGPAVLAPITGGALVLVVFVLVELRVSTPSLDVRLFRNARFSGATVSVMLTYFSLSGSMFYTAFYLQGVRDQTPFEAGLNLVPVAAGVLTGAPLSAGLVRRFGLGPVVGPAMLAAAGTFLAYTGIGTGTPMAWFWLLLFVQGAAMGAAMAPTTEAVMAVLPPDRTGAGSAVNNSMRQIGGVLGVAVLGSLLTTTYRSQIEPALAPLPAQVSRPASASAEATRQLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAX0</accession>
    <name>A0A0F4JAX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">VR44_19285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000528">
        <property type="protein sequence ID" value="KJY30908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948788.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000528.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5428"/>
    <dbReference type="EnsemblBacteria" id="KJY30908">
        <property type="protein sequence ID" value="KJY30908"/>
        <property type="gene ID" value="VR44_19285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8463"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY30908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="29712" checksum="C35C57FBBC4A2A13" modified="2015-06-24" version="1">MSAQILDGKATAAAIKSELTARVAALKERGVTPGLGTLLVGDDPGSRWYVNGKHKDCAEVGITSIRRELPDTASQEEIEAVVRELNEDPACTGYIVQLPLPKGIDTNRVLELMDPAKDADGLHPTSLGRLVLGVQGPLPCTPYGIVELLRHHGVEINGAHVVVVGRGITVGRSIGLLLTRKSENATVTLCHTGTRDLAGLLRQADIIVAAAGVPHLVKPEDVKPGAAVLDVGVSRDENGKIVGDVHPGVAEVAGWISPNPGGVGPMTRAQLLVNVVEAAERAGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB62</accession>
    <name>A0A0F4JB62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948746.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000522.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3418"/>
    <dbReference type="EnsemblBacteria" id="KJY31039">
        <property type="protein sequence ID" value="KJY31039"/>
        <property type="gene ID" value="VR44_19070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8418"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9391" checksum="955FAA01961507E2" modified="2015-06-24" version="1">MAERRVNVGWAEGLHARPASIFVRATTASGVPVTIAKAGGDPVNAASMLAVLGLGAQGGEEVVLASEAEGAEVALDRLAKLVAEGLEELPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBL1</accession>
    <name>A0A0F4JBL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949030.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30371">
        <property type="protein sequence ID" value="KJY30371"/>
        <property type="gene ID" value="VR44_20620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8839"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="12"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="28291" checksum="F0751566927DF79F" modified="2015-06-24" version="1">MGMNVSYTSFVAVGDSFTEGMSDLLPDGSYRGWADVLAARLAAREPGFRYANLAVRGKLIGQIAEDQAPAAAAMGADVVTLVGGLNDALRPKVDMGRVRGHLEAAVELLAPSCGRLVLMRSPGRHGPVMERFRPRMEELFTILEELAARHGALLVDLYGAPVLGDPRLWDADRLHLTAEGHRRVAEAVWQALGLPAEEDWTASLPPATAPGWGVRRTEDLRFAKRHLLPWIGRRLTGRSSGDGRPPKRPELLPYATPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBZ1</accession>
    <name>A0A0F4JBZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000500">
        <property type="protein sequence ID" value="KJY31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948619.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31329">
        <property type="protein sequence ID" value="KJY31329"/>
        <property type="gene ID" value="VR44_18400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8229"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="345" mass="37464" checksum="10C3873D3ABC4769" modified="2015-06-24" version="1">MADAKVIPFGEDRPRRRGGGARGARAVDAVAAPAQPPGPSRESGPVGLPSPVEESVEAPAGRAGGAGEWDRRIAGGLAFLRRRITGEYEVDEFGYDKELTDQVLMSLMRPLFDKYFRVEVKGVENIPKEGGALIVANHSGTLPLDGLMLQVAVHDHHPAERHLRLLAADLVFMLPGVNELARKAGHTLACAEDAQRLLEAGELVGVMPEGFKGIGKPFGERYKLQRFGRGGFVSTALRAGTPIVPCSIVGAEEIYPMIGNAKTLARLLGLPYFPLTPTFPWLGPLGAVPLPTKWTIQFGEPIPTDGYAAEAAEDPMLMFNLTDEVRERIQHTLYKLLVQRRSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM0</accession>
    <name>A0A0F4JCM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948292.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32102">
        <property type="protein sequence ID" value="KJY32102"/>
        <property type="gene ID" value="VR44_16610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7754"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28988" checksum="CDE41F59D19F6112" modified="2015-06-24" version="1">MWRGAVLALAGTYFLLPLLASSVFTVHVPGQGLTFQAYTELLGADGFSQSLLLSLGLAAATIVLSLLLAVPALVAVRIGSPRLRPVVEVVCMLPLVVPPIALVTGITTVLRWGPEHLSRTPLYQTFIAVQDERFPVVLVLAYTVLALPFVHRSLDAGLRAVDVPTLVEAARSCGASWPYVVWRVLLPNLRTSLAGAAFLTLALVLGEFTIASLLGFRPFAVWIVSVSGAQARMSVAVSILSLLITWLLLLFLSRAGTAPSTTAAAPATSRKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDE1</accession>
    <name>A0A0F4JDE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000526">
        <property type="protein sequence ID" value="KJY30971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30971">
        <property type="protein sequence ID" value="KJY30971"/>
        <property type="gene ID" value="VR44_19160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8438"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="40362" checksum="397FDBA5B9B09ED5" modified="2015-06-24" version="1">MLGASLLSGCGSTPAAGDEADCPAGQVSRGGVCLPRDAAAFARAQVQGSLTKSKLTASMAEVWTGGERVASVAAGESMTGIPATPDMRFRNGAVAIPYLTTALLKLVDEGRVSLDDSISRWRPDLPHADAITLRMLASTTSGYADYVRDPKFIATLYANPFRQWTPQELVKMSVDRPLVREPGSGFAYSHANWQILGDVIARVRDRPLGEVMREEIIEPLGLTGTSNPSTAEIPAPVLHAFDNERKVFEDSTYWDPSWTIAPGAVMTSTMADMAKSFAAIGEGRLLTPESHKAQLTPVATVEPGTSYALGLVVRNGWILQNPSFAGYAATVAYLPAKKLAIATVTTQGKGSTVQNASTDVLVALANHLAPDHPLTLRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDH1</accession>
    <name>A0A0F4JDH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000524">
        <property type="protein sequence ID" value="KJY31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948754.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000524.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31001">
        <property type="protein sequence ID" value="KJY31001"/>
        <property type="gene ID" value="VR44_19100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8424"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22878" checksum="DB25E9B3E858BD8B" modified="2015-06-24" version="1">MLGVTDLPTYLAAVVLIVLLPGPNSLYVLSVASRRGVKEGYKAACGVFTGDTVLMVLTAVGAGALLQASPVLFTVVKVLGAGYLGWLAVGMMRAAAVMWRARRTREEEPDAAGAEPAGAAERPYRRALLVSLLNPKAILFLLSFFVQFVDPGYAHPALSFLLLGTVSQLVSFLYLSTLIFAGTRLSAAFRRRKRLSAGATSAAGVIFLGFAAKLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDK1</accession>
    <name>A0A0F4JDK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948743.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000522.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3414"/>
    <dbReference type="EnsemblBacteria" id="KJY31036">
        <property type="protein sequence ID" value="KJY31036"/>
        <property type="gene ID" value="VR44_19050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8414"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="185"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="48732" checksum="6F7A684B178C25D7" modified="2015-06-24" version="1">MGHTATAQAGSGGLTATEHRLANGLRVVLSEDHLTPVAAVCLWYDVGSRHEVKGRTGLAHLFEHLMFQGSASVKGNGHFELVQGAGGSLNGTTSFERTNYFETMPAHQLELALWLEADRMGSLLAALDEESMENQRDVVKNERRQRYDNVPYGTAFERLTALAYPEGHPYHHTPIGSMADLDAASLEDARNFFRTYYAPNNAVLSVVGDIDPERTLAWVEKYFGSIPSHDGKQPPRDGTLPEIMGGQLREEIVEEVPARALMAAYRLPHDGTRECDAADVALTILGGGESSRLHNRLVRRDQSAVAAGFGLLRLAGAPSLGWLDVKTSSGVEVPAIEAAVDEELARFAAEGPTADEMERAQAQLEREWLDRLGTVAGRADELCRFAVLFGDPQLALTAVQRVLDVTAEEVQAVAAARLRPDNRAVLVYEPLPGAEENDESDENEGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEH9</accession>
    <name>A0A0F4JEH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948580.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31386">
        <property type="protein sequence ID" value="KJY31386"/>
        <property type="gene ID" value="VR44_18205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8188"/>
    <dbReference type="eggNOG" id="ENOG5033RYZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="520" mass="53990" checksum="324C3D345C993D39" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF42</accession>
    <name>A0A0F4JF42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000391">
        <property type="protein sequence ID" value="KJY32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948016.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000391.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32825">
        <property type="protein sequence ID" value="KJY32825"/>
        <property type="gene ID" value="VR44_15200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7377"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="26669" checksum="C7912DB4DAE37D0D" modified="2015-06-24" version="1">MTTNEVSDPTVHPYTREMAMIHRVFRRESRLLAELVQDVRAADTARARILAEHWRQYTVGLHAHHTGEDEMLWPVLLPHLDLDAEQVLAMEAQHRELTEGMDEVQVHMDRWQARALPADRDELAEALRRHHRQLCAHLDEEERQVMPLVALHVGEEDWKAVGERGLAETPRDRLMIALGAILEDCPPEERREFLARLPVPARVLWKLLGQRQYRRETRRIRGRHTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGV9</accession>
    <name>A0A0F4JGV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000429">
        <property type="protein sequence ID" value="KJY32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32216">
        <property type="protein sequence ID" value="KJY32216"/>
        <property type="gene ID" value="VR44_16385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10765" checksum="17BA6FE1E7D14963" modified="2015-06-24" version="1" fragment="single">MRIVEGDLGTLDADELAAATGGVRELIHAAAEVRHYGPDDRYATNNVAPTSLLARLALDRGWRMAHMSTLSAVGPAPGDGPLVTLREEDFDRGENFDSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIY6</accession>
    <name>A0A0F4JIY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000342">
        <property type="protein sequence ID" value="KJY33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33738">
        <property type="protein sequence ID" value="KJY33738"/>
        <property type="gene ID" value="VR44_13430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6922"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="143"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="31274" checksum="8BC1E9C760ACAF9B" modified="2015-06-24" version="1">MNRVTTIVLTALAPISWGSTYFVASELLPPDRPLFTGAMRALPAGLLLVALSRALPKGAWWWKSAVLGTLNIGAFFPLLFLAAYRLPGGVAAVLGSAGPLFVVGLAALLLGEKAKLRNVLAAIVAALGVSMVVLTSQAQLDLVGVIAGIVSSASMGAGTVMTKRWGRPEGVGPLAVTGWQLTAGGLVIIPIAALIEGAPPALDGKAFLGYGYMMLINTGAAYFLWFRGIGKLSATSVTLLGPLSPLTAAVIGWAALGQALSPVQVLGMVIAFGATVFGQLPGRAAKPKAAESQQAPLTETPKIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJD1</accession>
    <name>A0A0F4JJD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_14605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947908.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33066">
        <property type="protein sequence ID" value="KJY33066"/>
        <property type="gene ID" value="VR44_14605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7247"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="4">
        <location>
            <begin position="118"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="40589" checksum="D9B2F12E009F6E0D" modified="2015-06-24" version="1">MSTPPPQPPRPVGPGHSWPPPSPQPGWGPPPGPAGAPALNGFALASLLVGLLCFPPLGVVFGLVALVQIGRRQERGRALAVVGLVVSLVTTAVMLYGLVSWTRPFLERLGSRPVPERVEGQLTDMGRLRTGDCFNVPGGDLLDETPFTYRTDCAQVHDAEVTAATVLGPGPFPGASKLKDSATDACWKAQDAYAMDTWALPDYVEMYYFAPTREAWRAGDRRLICVIGTSGHDHRGSLRKDAGMLTPEQVSLLTALNAADGALGRAPERELDEALPEYRSWAREVDGALGAEERMLRDAAAAHPEAGARLKELAAARTQWQRAAGAVRPSDFRQAWDAAEGALTTGTEQALRGAYGLSTRVPEWIEENQGGSGRGPSSDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJE6</accession>
    <name>A0A0F4JJE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947395.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34447">
        <property type="protein sequence ID" value="KJY34447"/>
        <property type="gene ID" value="VR44_11795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6364"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="22212" checksum="FD31380D3FE94AFF" modified="2015-06-24" version="1">MNAHPTGPRARSHTASPPDPQRLMEIYLNDHLAGAGSGVSLIRRMVRAHRDGPAGPTLAALAEEITEDRSSLRAFMTALDVPVRWPRVAAGRVAEKAGRLKPNGRLASRSPLSDVLELETMRLGVEGKASLWRSLRVLALTDPRLDPADLDRLLARAARQESVLEALRTEAARRAFTTPATASARARGHGRPARHGVPGRARWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKN5</accession>
    <name>A0A0F4JKN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947775.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33506">
        <property type="protein sequence ID" value="KJY33506"/>
        <property type="gene ID" value="VR44_13785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7036"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="57"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="27668" checksum="849DE9AE051F2AA5" modified="2015-06-24" version="1">MAKAAALAYKDEATVAATAREWGFDRVRHHHTRFTPPFPLEDTQAYTVASDKMIITGFRGTEPAQIRDWLSDATTPPYPGPGNTGYIHYGFGRALDSVFPAVKEAVADFRDNDQSVWFTGHSLGGALAMLAGCRMYLEEPRLQADGIYTYGQPRTCDRLLAASCNKGFKDRLHRYVNNNDIVPQLPPEPAYTHVETLHYIDASGRVRASMPLLGALGDHVKGATADLLAPAGDALRDHPVKQYVAALEKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKS3</accession>
    <name>A0A0F4JKS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_13725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33556">
        <property type="protein sequence ID" value="KJY33556"/>
        <property type="gene ID" value="VR44_13725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7021"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027573">
        <property type="entry name" value="Methyltran_FxLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04364">
        <property type="entry name" value="methyltran_FxLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="102"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="690" mass="74009" checksum="68BB94ED8BCBC814" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLI1</accession>
    <name>A0A0F4JLI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000270">
        <property type="protein sequence ID" value="KJY34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34679">
        <property type="protein sequence ID" value="KJY34679"/>
        <property type="gene ID" value="VR44_11500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6202"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13115" checksum="56BCFD4BC634C331" modified="2015-06-24" version="1" fragment="single">AGPVGAITATAPVTDGETVELTPAELSAIRQIADEIKQETTQNDGPAPGVSAFSAKGEAGKKFIELLKKSPGLFKSAVSKAKEGRDAFNKWMGKQNVAVRGAWWLLSGGVQTWVFDELVKMVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLL9</accession>
    <name>A0A0F4JLL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947227.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene456"/>
    <dbReference type="EnsemblBacteria" id="KJY35080">
        <property type="protein sequence ID" value="KJY35080"/>
        <property type="gene ID" value="VR44_10895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6059"/>
    <dbReference type="eggNOG" id="COG3824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13978" checksum="B483784B70E19B9A" modified="2015-06-24" version="1">MRGPLAPPQVPLSASRAELFGDLVRDSVERLERRWPQLDEVEFVVADVPGPPGGPDGGWNDEAVPLGGLVEARDGRPARIVVFRRPVEIRAKSRDERALLVHEIVVEQVAELLGLSPETVDPRYGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLW2</accession>
    <name>A0A0F4JLW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase-modifying factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000229">
        <property type="protein sequence ID" value="KJY35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35342">
        <property type="protein sequence ID" value="KJY35342"/>
        <property type="gene ID" value="VR44_10345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12456" checksum="D46B2396B027A41B" modified="2015-06-24" version="1" fragment="single">MDTSAEPEMIDIPAGQIVLSDRRTQRSWAVELAPYQLAAYPITQALYARIADGHPSAAHGDRIPVDSVSWWDAVRFCNALSQRDGFAPVYQFQADGEEIEWDASADGYRLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN78</accession>
    <name>A0A0F4JN78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_09065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000196">
        <property type="protein sequence ID" value="KJY35822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946890.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000196.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35822">
        <property type="protein sequence ID" value="KJY35822"/>
        <property type="gene ID" value="VR44_09065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5077"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471199" description="NlpC/P60 domain-containing protein" evidence="4">
        <location>
            <begin position="40"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="237"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="37391" checksum="C2215B8F43C11D3B" modified="2015-06-24" version="1">MGSHRRPGSGGLDRNAKLTVLTAAAATAAVAMTGAPAGAAPNLPQDPATSSRAQVDRLFEEAEQATEKFNRAGEKADALRAEISRAQDAVARAQDRVNTMRGVLGTFAGAQYRSGGLDPTVELMLSEDPGAYLDKAAVLDRLSGRQTEQLAELREEQRRIGRQRQEASRKLAELEALRTEVATQKRAVTAKLADARRLLEAMPSEERADFERASRSGGRADALPDLPDLPPGGGHASGRAMTAVMAARAAVGKPYVWGSTGPSGFDCSGLMVWSYRQAGVSLPRTSQAQRYAGRRVPLSQAQPGDLVTYRSDASHVAMYVGNGQVIHAPYPGARVRYDPVGMMPVSSVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNG5</accession>
    <name>A0A0F4JNG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947399.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34451">
        <property type="protein sequence ID" value="KJY34451"/>
        <property type="gene ID" value="VR44_11815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6368"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19067" checksum="A2AC29281CBF1A51" modified="2015-06-24" version="1">MRIAFLTAPEGVEEVELTRPWKAVLGAGWTPRLVSTEAGEVQAMRHLDKAGTYPVDRVLTGRTDESFDALVLPGGVANPDALRMNGTAVDFTRGFFEAGRPVAAICHAPWLLVEADVVRGRTLTSWPSLATDIRNAGGTWVDEEVHVCRAGSSPLVTSRKPDDLDAFCEAFVTVFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP13</accession>
    <name>A0A0F4JP13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000270">
        <property type="protein sequence ID" value="KJY34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947343.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000270.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34681">
        <property type="protein sequence ID" value="KJY34681"/>
        <property type="gene ID" value="VR44_11510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6204"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470716" evidence="1">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17316" checksum="E240C9B4454EC354" modified="2015-06-24" version="1">MTVGVATVLVAGPAWASPHQVSRTAPAAAALSNSDLEVVRLDPEPATPGGSTTIQGFVGNLGPETTASPFVVTVSLPHGVTPEKPYWPDTCVLSSSRRQVHCEFSAGLKKDRSATALVPVRLDDELKVGTVVKGGWVSVRSLDDRNPLNNRAPFEITVVETAPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP38</accession>
    <name>A0A0F4JP38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35609">
        <property type="protein sequence ID" value="KJY35609"/>
        <property type="gene ID" value="VR44_09760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5452"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471098" evidence="4">
        <location>
            <begin position="41"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="42920" checksum="124200A112992A12" modified="2015-06-24" version="1">MSRSRRTALPRRRVRHAALAGTALLAAALTACSGGSGDGADGGGKAADAKNKAPMAVSVNLTDGQVKSGEPVKVTIADGKLAQVKVTDGKGGELAGQIAADGKSWTSGRNAAPNTDYKVEAQSTDSQSAGTQFKTSAADKVNKVSINVAKGSTVGVAMPVSLVFDNPVKNKAEVEKQLKVTTSNNTEGSWGWFKDYSGNDRVDWRPKDYWKSGTDVKVEMNLNGVDSGPGGGLFARDYTTEFRIGKDRRMEVSLDTKKMSITEDGQVVKTVPVSAGTPGGEKASWSGKMVLMSKEGTIFMDSQTVGLGDSYAKMVDYSMRLTWSGMYVHAAPWNDDKFGKTNASSGCVGMSNANAKAVYEQAQPGDPLEVVGSGSKGKADLGNGYGEWNLQWDQWKAKSALTGATQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPD5</accession>
    <name>A0A0F4JPD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947023.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35613">
        <property type="protein sequence ID" value="KJY35613"/>
        <property type="gene ID" value="VR44_09780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5456"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470729" evidence="4">
        <location>
            <begin position="26"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="62"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="62"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32561" checksum="C4A1890ED9B30441" modified="2015-06-24" version="1">MKHPLRALALALALLAAAAGCGKSGSPPVKGPQPEDLPVYRVDTDFTLPASPTWEKAKRRGHLVVGAKEDQPYMGEKDPASGRYSGFDIEIAKMMAASLGFDPKTTEFKTIASANRETALQNGQIDYYVGTYTINDKRKKQVGFAGPYFMAGQSLLVRRGEKDIKGPEDLAGKRVCSAAGSTPYQRLQNDFPKAVLVAYDTYSVCVDNLLTYQVDAVSTDDSILLGYAAKVPDELKVVGKPFSQEPYGIGVPRSDNALRFALDDALAAHEKNGDWKKAYEATLGLSGQPAPKPPAIDRYPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPU5</accession>
    <name>A0A0F4JPU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000163">
        <property type="protein sequence ID" value="KJY36402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36402">
        <property type="protein sequence ID" value="KJY36402"/>
        <property type="gene ID" value="VR44_08125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4452"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="4">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12344" checksum="42873262705FFFE1" modified="2015-06-24" version="1" fragment="single">RVAIARALAVEPAVLVLDEAVAALDVSVQAQILNLLADIREQTRIGYLFITHDLGVVRCVTDELVVMRRGRVVEAGATAEVLAAPRHAYTRLLLESVPRPGWDPEAIAAARRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPX9</accession>
    <name>A0A0F4JPX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VR44_09110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000197">
        <property type="protein sequence ID" value="KJY35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946895.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5121"/>
    <dbReference type="EnsemblBacteria" id="KJY35813">
        <property type="protein sequence ID" value="KJY35813"/>
        <property type="gene ID" value="VR44_09110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5086"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="38414" checksum="BD3F20E9346A16FB" modified="2015-06-24" version="1">MSSQDIPEDKHLPSEQGDAHHGAVAVADDPFADPGLPVHKPRIQDIDERAAKRSERTVAMLFTLSMLATVGFIASYVSIPVDKIIYVFPIGKVSALNFALGLTLGVALFCIGAGAVHWARTLMSDVEVADDRHEIAAPADVKAKVMQDFADGANESGIARRPLIRNTMLGALALVPLSGVMLLRDLGPLPEKKLRKTVWSKGKLIINQNTMEPLRPEDVLVGSLTFAMPEGLEEDQHDFQVQIAKAALMLVRIKPEDIKDKQELEWSHEGIVAYSKICTHVGCPISLYEQQTHHVLCPCHQSTFDLSDGARVIFGPAGHALPQLRIGVNDEGFLEALGDFEEPVGPAFWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ12</accession>
    <name>A0A0F4JQ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000194">
        <property type="protein sequence ID" value="KJY35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946886.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000194.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35853">
        <property type="protein sequence ID" value="KJY35853"/>
        <property type="gene ID" value="VR44_09010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5065"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26936" checksum="CD1071018627C291" modified="2015-06-24" version="1">MPDALPRSRTEPDGSAVIRVLGYNVRSMRDDEEALARVIRACAPDLVLIQEAPRFFRWRKHAARLAAKTDLVVLGGGATAAGPLLLCSLRAFVERTEDVLLPLTPGLHRRGFATAVVRFGAARVGVVSAHLSLDATERAAQAELLLERAAALDAPHVIAAADVNEAPGGPAFTRLSDTLQDCWTTAPWGGADTFPSAAPSRRIDAVFASLRIDALFASPSVEVLACGVPTGLPTTDLRTATDHLPVLAAVRLGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQH1</accession>
    <name>A0A0F4JQH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946805.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36099">
        <property type="protein sequence ID" value="KJY36099"/>
        <property type="gene ID" value="VR44_08620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4866"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="291"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="666" mass="74394" checksum="5F13C330D6FFEF5C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSW1</accession>
    <name>A0A0F4JSW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946326.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37270">
        <property type="protein sequence ID" value="KJY37270"/>
        <property type="gene ID" value="VR44_06050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2546"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21593" checksum="A9DD0605BDA6C5AD" modified="2015-06-24" version="1">MSAPMSTDRFIHALRAEGLTVVEVGNWRTHNRNHKGPWGPVHGVMIHHTVTHGAAYTVELCRDGDRALPGPLCHGVITKDGRVHLVGYGRANHAGAGDSDVLAAVVAERRLPPVHHADTDGNRFFYGFECENLGDGRDPWPPAQLDAMARAAAAVCRVHGWTARSVIGHLEWQPGKIDPRGFTMDWLRERIADRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT49</accession>
    <name>A0A0F4JT49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_05755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946271.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2536"/>
    <dbReference type="EnsemblBacteria" id="KJY37365">
        <property type="protein sequence ID" value="KJY37365"/>
        <property type="gene ID" value="VR44_05755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1966"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="47000" checksum="81833A795CF20A64" modified="2015-06-24" version="1">MTGAYQLITGAVLLTVVAWFAACAESGIARVSSFRAEQAVREGRRGSAKLAQVAGDPTRYVNVALLVRVTCEMAAGVLVTYVCLDAFGENWTALLVAIAVMVLVSFVAVGVSPRTIGRQHPLNTATAAAYVLVPLARIMGPIPQLLILIGNALTPGKGFRKGPFASEAELRAMVDLAEKESLIQDEERRMVHSVFELGDTLVREVMVPRTDLVCIERYKTIRQATTLALRSGFSRIPVTGENEDDIVGMVYLKDLVRRTHINREAETDLVSTVMRPAVFVPDTKNAGDLLREMQSVRNHVAVVIDEYGGTAGIVTIEDILEEIVGEITDEYDREIPPVEELGDDRYRVTARLDITDLGELFGALAFDDEDVETVGGLLAKALGRVPIAGASAVVDLPDGRPLRLTAESPAGRRNKIVTVLVEPVVPEAGEGEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTI5</accession>
    <name>A0A0F4JTI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000122">
        <property type="protein sequence ID" value="KJY37058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946440.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37058">
        <property type="protein sequence ID" value="KJY37058"/>
        <property type="gene ID" value="VR44_06635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="28609" checksum="83CB4DADB1514EF9" modified="2015-06-24" version="1">MARVVAGVAVPGEVLLVLCLAAGVRPPVWVTGGVEGLVLGVLLLEGWLLGSLRRRTGSWREAVRAVVPERVRRLLLHELRACASLGRWVARRPHGVRPGDLAAAYTGPQTAMMYGLLFVSVIETVGLALLIPWPAVHRVVLVLDVYGMLLVLALHAACVTRPHVVRPDGTLRIRYGALFDLTVPPDAVASARVDRRYPEGRLVTLTEDGVLDLIVGSQTTVTLELNRPLEFRRPLGARARARTVRFHADDPRALVTALRQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTV8</accession>
    <name>A0A0F4JTV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-methylisocitrate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946121.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37797">
        <property type="protein sequence ID" value="KJY37797"/>
        <property type="gene ID" value="VR44_04935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1074"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="30781" checksum="28A5D0D2554D39CB" modified="2015-06-24" version="1">MNDTRPSTDPAARIRRGEAFRELHHGPGPFVVPNPWDAGTARILASFGFAALATTGAGLAHSLGRPDGANRLTRAELLANAAAIVDATGLPVTADLESGFGERPEDVAETIRLAAEAGLAGGSIEDATGRDEDPLRPVDEAVERVAAAVEAAKGLGFPFTVTARAENFFLGRPDLADTIRRLQAYEAAGADVLYAPALPDAEAIRAVCAAVSRPVNVLMTGALKLSVAELGALGVRRISTGSALSRAALGALTRAAREITESGTFGFGADALPYAEANALLEHDSPHSLDRSTRSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU00</accession>
    <name>A0A0F4JU00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_05960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946310.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37314">
        <property type="protein sequence ID" value="KJY37314"/>
        <property type="gene ID" value="VR44_05960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2406"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="466" mass="48479" checksum="891E9EF06C1E9DF4" modified="2015-06-24" version="1">MSQSTITPPELRPSAPGSPLGNGLKQRHLSMIALGGVIGAGLFVGSGAGIAAAGPSIVLAYAVSGLLVMFVMRMLGEMSAADPASGSFSVHAERAIGPWAGFTAGWMFWTLLCVGVAIEAIGAAHIMTGWFPGTPSWLWVLVFMALFCGSNLGAVRNFGEFEFWFAALKIGAIGLFLGLGVLAVLGLLPGTSSPGAANLVHDGGFLPNGVDGLLVGVLASVVAYGGLETVTIAAAESDDPVRGVAKAVRTTMWRIAIVYVGSMLVIVTLLPWNDPSVTGHGPYAATLDHLGIPAAGQIMNVVILAALLSAMNANIYGSSRMAHSLVSRGQGPKALGKVSGGVPRRAVLASSGFGFVTVLLSYWYPDTLFAWLLNMVGGVILIVWGFIAVSQFVLRRRLEREAPGKLTVRMWGFPYLTWVALAGVAAVLVLMAVGEDTRSQVLFTGGLAVALAATGYVMQRRAANRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUC8</accession>
    <name>A0A0F4JUC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946279.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37373">
        <property type="protein sequence ID" value="KJY37373"/>
        <property type="gene ID" value="VR44_05805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1976"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="243" mass="25850" checksum="EDAB0D37AF392E81" modified="2015-06-24" version="1">MDMRWEEAGWERVAERVGRRRLPVWDCTVGLVVGDDSMLLIDPGSSIREGAGIRAEAERLTGRHVTHIAFTHGHFDHVLGGPAFAGARFYGAVGLDRLLGTPGGREELRYSAVAQGLAEEEAAEACDLLKAPGHLVSGEWTLELGGVQVLLANLGPAHSEHDLAVFVPGERETVFCGDLVEESGEPQAGSDAVPGQWPAALDRLLSLGGEDALYVPGHGAVVDAGFVRAQRDTLADRFGVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUX7</accession>
    <name>A0A0F4JUX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946053.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37955">
        <property type="protein sequence ID" value="KJY37955"/>
        <property type="gene ID" value="VR44_04600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1001"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20758" checksum="5EBBA9ACDB32A38A" modified="2015-06-24" version="1">MSDGPLLHPAEMDRIREGIAAAVLEAPEGLAASLEHDAHGYLRLVDASRVGAEEASRLLREAVQGARAAGHSWDTVGRVLGVSRQAAQQRFASKAAAAPAAGGTDGPARRTLKGLSAFNEMTALEEAGRDGWHLVGYGPLFHTVEASGRPWEHCRVTLPSGARQRRMQDEGWIPVGAGWFPWRYYKRPLGSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWU3</accession>
    <name>A0A0F4JWU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the darcynin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945729.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38852">
        <property type="protein sequence ID" value="KJY38852"/>
        <property type="gene ID" value="VR44_02765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6795"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031409">
        <property type="entry name" value="Darcynin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17074">
        <property type="entry name" value="Darcynin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="13813" checksum="AEFFD9F45AE297F5" modified="2015-06-24" version="1">MTYGIVLTYTLTPRWLALPREERNRMRAAHIEPVFARYADRVTARFFDAEAFSGRFSDFAVLETEDLGAYYFLIEALRDTPLIHDGHLVLGEVILGVRDGFQTYEHHLAPAPGTTPATEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWZ5</accession>
    <name>A0A0F4JWZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000104">
        <property type="protein sequence ID" value="KJY37486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37486">
        <property type="protein sequence ID" value="KJY37486"/>
        <property type="gene ID" value="VR44_05585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="21527" checksum="63E87D0C4570F081" modified="2015-06-24" version="1" fragment="single">GAGRRLRAAATGTPPGQGHRVTGVELADGYRLAADVVVLACGVRPRTGLARAAGLEVRKGIVVDDRLRTSDPYVHAIGDCAEHAGRVYGLAGPALEQADALAAVLTGSPTEYTGTRALTRLTLGGAGRPLDLAAFGDPTPLPGDDVVRLADATRRTYRKVVLRGGRLVGGVLLGELSTVGALARTWEGEESLDAPHDTFHLLTDDGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX49</accession>
    <name>A0A0F4JX49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945755.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38725">
        <property type="protein sequence ID" value="KJY38725"/>
        <property type="gene ID" value="VR44_02915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7315"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="20846" checksum="96C0CEF09FB3A8C0" modified="2015-06-24" version="1">MVRAKSEERRGEIVRAALEVIAERGYRGASLGSVAERVGLTQQGLLHYFPTKEALLVAVLEERDRWDTGGGSRASAETWRLDLLAALVEYNAMRPGIVQTFSALLGESVTEGHPARAFFTERYAQVRGEMAALLRAEFGELLPSGLTPEQAAPLLTAVMDGLQYQWLLAPESVDMPAAFRSFLTLLRGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYC9</accession>
    <name>A0A0F4JYC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38854">
        <property type="protein sequence ID" value="KJY38854"/>
        <property type="gene ID" value="VR44_02725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6786"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12219" checksum="D46A16831FF90C7D" modified="2015-06-24" version="1" fragment="single">MAASKRDYYDVLGVPRNAGAEEIQRAYRNLARRWHPDLNKDPEAEERFKEISEAYEVLSDPENRKRYDHFGHAWQQAGKGSAPGPGGPFGGGGGRRVYVNTGGGPGLGGGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0P2</accession>
    <name>A0A0F4K0P2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">VR44_00395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956441.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4K0P2"/>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1047"/>
    <dbReference type="EnsemblBacteria" id="KJY39955">
        <property type="protein sequence ID" value="KJY39955"/>
        <property type="gene ID" value="VR44_00395"/>
    </dbReference>
    <dbReference type="GeneID" id="58435565"/>
    <dbReference type="GeneID" id="63982148"/>
    <dbReference type="GeneID" id="66955264"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.77"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="37" mass="4389" checksum="349DC4355BFEF0C8" modified="2015-06-24" version="1">MKVKPSVKKICDKCKVIRRHGRVMVICDNLRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3B2</accession>
    <name>A0A0F4K3B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_00840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945373.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4776"/>
    <dbReference type="EnsemblBacteria" id="KJY39666">
        <property type="protein sequence ID" value="KJY39666"/>
        <property type="gene ID" value="VR44_00840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2874"/>
    <dbReference type="eggNOG" id="COG1023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="31568" checksum="3D610DC6A3018FFF" modified="2015-06-24" version="1">MELGLVGLGKMGGNMRERIRRAGHTVIGYDRNPDLADVHSLRELVDSLQAPRVVWVMVPAGAATQSTVDELAELLSPGDIVVDGGNSRWTDDEKHAKELEAKGIGFVDCGVSGGVWGLENGYALMYGGDEKHVAAVQPVFDALKPEGDFGAVHAGKVGAGHFAKMVHNGIEYAMMQAYAEGWELLEKVDSVTDVREVFRSWQEGTVIRSWLLDLAVNALDEDEHLDQLKGFAQDSGEGRWTVEAAIDNAVPLPAITASLFARFASRQDDSPQMKMIAALRNQFGGHAVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K458</accession>
    <name>A0A0F4K458_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">VR44_00350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812337.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1038"/>
    <dbReference type="EnsemblBacteria" id="KJY39946">
        <property type="protein sequence ID" value="KJY39946"/>
        <property type="gene ID" value="VR44_00350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.68"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19060" checksum="98F42A4C159DC10C" modified="2015-06-24" version="1">MSRIGKLPIPVPAGVDVTIDGRTVTVKGSKGSLTHTVAAPIEIVKGEDGVLNVTRPNDERQNKALHGLSRTLVANMITGVTTGYTKALEISGVGYRVAAKGSDLEFQLGYSHPILVEAPEGISFKVESPTKFSVEGIDKQKVGEVAANIRKLRKPDPYKAKGVKYAGEVIRRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1I8</accession>
    <name>A0A0F4I1I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001825">
        <property type="protein sequence ID" value="KJY15890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15890">
        <property type="protein sequence ID" value="KJY15890"/>
        <property type="gene ID" value="VR44_40710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="KAsynt_C_assoc" evidence="2">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY15890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8424" checksum="0A92D566240A79B8" modified="2015-06-24" version="1" fragment="single">TQAAAGVAGVIKLVLALQNAELPRTLHVDAPTPHVDWSAGSVELLSAPVAWPETSGHVRRGGVSAFGVSGTNAHVIIEQAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1K2</accession>
    <name>A0A0F4I1K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001846">
        <property type="protein sequence ID" value="KJY15812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15812">
        <property type="protein sequence ID" value="KJY15812"/>
        <property type="gene ID" value="VR44_40795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7140"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7522" checksum="FBA49BEC9552E66F" modified="2015-06-24" version="1" fragment="single">PAGPVSVVGDFNHWNPLAHPLTPQGDGTRTASVALPAHSTHSFRYLAAGDYWFNDDTADSHDGPNSRIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3Y1</accession>
    <name>A0A0F4I3Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_40345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001729">
        <property type="protein sequence ID" value="KJY16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16632">
        <property type="protein sequence ID" value="KJY16632"/>
        <property type="gene ID" value="VR44_40345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KAsynt_C_assoc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24541" checksum="77A0391E62CFE3BD" modified="2015-06-24" version="1" fragment="single">EPSPHIDWTSGAVRLLTEPVEWTDGPRPRRAAVSSFGFSGTNAHVVLEQAPEPAPEPAAEAGPAAPFAAPWLLSAKTPDALRAQARSLLPYAQDPGRAALDVAYSLATGRNALEHRAAVIAPDPAGTREALTALADGAPSRAVVRATAVAGSGKHAFLFSGQGSQRLGMGRELHAVFPVFARAFDAACAALDPHLELPLRDVVFGDDAELLGETRFTQPALFAVEVALFRLVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7A0</accession>
    <name>A0A0F4I7A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001675">
        <property type="protein sequence ID" value="KJY17343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17343">
        <property type="protein sequence ID" value="KJY17343"/>
        <property type="gene ID" value="VR44_40020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10368" checksum="A61C13EAFF40C224" modified="2015-06-24" version="1" fragment="single">VEGRTRRVAAAGAVGLLRAPAPAPVPAGRHAVRAVDEGHPLRSWTLRPGSPPVHGLSVPLARQGTSYGILLAVRTGAAFTDHEAAALHFAARVAAVHLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9Y6</accession>
    <name>A0A0F4I9Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001577">
        <property type="protein sequence ID" value="KJY18880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18880">
        <property type="protein sequence ID" value="KJY18880"/>
        <property type="gene ID" value="VR44_39335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12231" checksum="E8E218814718485A" modified="2015-06-24" version="1" fragment="single">EEGVRAVLAGRRIGSPVVPFVSSVSGQLCTDPGALRELWARHASGPVRFGDAVRTAYEQGARVFLQVNGGASLLTAVRRNLYHHDDVHLLTADAGAERDAGRGFVRTLARLAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGJ2</accession>
    <name>A0A0F4IGJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001496">
        <property type="protein sequence ID" value="KJY20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20573">
        <property type="protein sequence ID" value="KJY20573"/>
        <property type="gene ID" value="VR44_38635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5401"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="23163" checksum="FE24B5B8EC5B9BC9" modified="2015-06-24" version="1" fragment="single">MTTSNDKIVQALRASLQETERLRRQNRKMTAEAREPIAIVAMSCRFPGGVTSPEDLWTILAEGEDALSAFPRNRGWDLDSLYHPDPQHPGTTYAREGGFLHDAGDFDAAFFGISPREALAMDPQQRELWSLLADGGDAISGFPADRGWDLDALYDPDPDHAGTCYVRHGGFLDGVGEFDAGFFGISPREALMMDPQQRLLLETAWEAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4II15</accession>
    <name>A0A0F4II15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001467">
        <property type="protein sequence ID" value="KJY21098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952312.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001467.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21098">
        <property type="protein sequence ID" value="KJY21098"/>
        <property type="gene ID" value="VR44_38380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5325"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469558" evidence="1">
        <location>
            <begin position="31"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="34657" checksum="5C88EDA45B201E08" modified="2015-06-24" version="1">MRREIFAGSAAVAVLLLTAGCGSGSGGNSAAKQDSVKPVGDSKQLDLYGSGYGSGSGDAPAGGGAKSGPAGQLKAQEVAGVGSAVTDGEGFTLYRFDKDTAKPPKSNCEGDCAQAWPVVLADDAQAGAGVDAAMLGSVTRSDGTKQLTLGGWPVYRYAKDTKAGDALGEGVGGTWHALGPDGKPAAAGKATGSASASGSGMGAGMGSGMGAGMNMGAGTNPPPGGKKVSLSVRQNAQLGGILQNAEGWTLYRFDKDSAWPMKFGCLDACLDTWKPAKPVDKTEVSGIPAELVGSVKRPDGSEQLTIDCWPVYTFTGDKQPGDVNGQGKQGLWFAVTDKGKKAKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INW9</accession>
    <name>A0A0F4INW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001380">
        <property type="protein sequence ID" value="KJY23722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23722">
        <property type="protein sequence ID" value="KJY23722"/>
        <property type="gene ID" value="VR44_37480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4915"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="11333" checksum="288878C4D19A7705" modified="2015-06-24" version="1" fragment="single">PAPSPSAPPAGDAKPAPGDVLPGMVGAAVARAQLAALTTGKPGTMAGYSRDKFTHWAEQGDKCDTREVVLQRAGKDVTRDAECRAVSGTWKSLYDGVTVNEASKLDIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP66</accession>
    <name>A0A0F4IP66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001350">
        <property type="protein sequence ID" value="KJY23835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23835">
        <property type="protein sequence ID" value="KJY23835"/>
        <property type="gene ID" value="VR44_37105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470133" evidence="2">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="13305" checksum="BE3527A15C6B112A" modified="2015-06-24" version="1" fragment="single">MRTFAQRLLLPGLTTLALAAAGCSSPAHTGSAGPGAAPGAPAAGGSQQLEVAAAPQGSADPTPLARTSTGEGRPEKSSLRVASYDKGSQRAVIAPAPKPPKGSQNSPSDGSPAPAKPVAVGDVIASAPAPGAPDGLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPE3</accession>
    <name>A0A0F4IPE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001336">
        <property type="protein sequence ID" value="KJY23897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23897">
        <property type="protein sequence ID" value="KJY23897"/>
        <property type="gene ID" value="VR44_36915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07496">
        <property type="entry name" value="Peptidases_S8_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034176">
        <property type="entry name" value="Peptidases_S8_13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470144" evidence="5">
        <location>
            <begin position="25"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="157"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="518" mass="51224" checksum="F31E34C3CBA3C33E" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQI6</accession>
    <name>A0A0F4IQI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_35790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001253">
        <property type="protein sequence ID" value="KJY24295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24295">
        <property type="protein sequence ID" value="KJY24295"/>
        <property type="gene ID" value="VR44_35790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4313"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="47038" checksum="E7EAD09F1A365834" modified="2015-06-24" version="1">MTAKVTEPEPAPPPWSDTRAPRRGGVGLMLLAGAVLISALGHAYVGLVGRVQISTPHYAAGLAVAALLAHLAVRLRAPYADPVLLPIAVLLNGLGLVLIERLDLATPGQAGAGDQLRWSGLGVGLFALVVVGLRDHRVLQRYAYLSVTAALALMLVPVFFPAVNGAHIWIRFAGLSFQPGEFAKILLAVFFASYLAANRTALALTGRRLFWRLRLLPGRVLGPILTIWLLSVGVLVLERDLGTSLLFFGLFVIMLFTATGRIGWIAVGLLLAALGAYAVGTLEPHVHSRVQDWMNPFASIARGEGPGQLAQSLFAFAAGGLLGAGLGHGHSFLIGFAAKSDFVLATAGEELGLVGLTALLLLYGLLVSRGFRAGLALRDPFGRLLATGLASIVALQVFVIAGGVTGLIPLTGMAMPFLAQGGSSVVTNWIIVALLVRLSDSARRGGTGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS88</accession>
    <name>A0A0F4IS88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001156">
        <property type="protein sequence ID" value="KJY24867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951520.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001156.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24867">
        <property type="protein sequence ID" value="KJY24867"/>
        <property type="gene ID" value="VR44_34120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3750"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20692" checksum="CED0105004217EFF" modified="2015-06-24" version="1">MGWTAEEFGASHEGWAGALLADGTEPGPVCLDPGNGSGFRQTREWWAYNGILNRPRAAAARAACACGWRGAAHYPIDLGGEDPSGLYEQVIDGPRDDWERHLDEVEARTVPLPAVLADLLERLEDQLNNLAGQAPVAALKAVAALERVTRSVARDAAYIAEADDLSWESIGTGLGISEKEARSRLSHYTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITT4</accession>
    <name>A0A0F4ITT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001128">
        <property type="protein sequence ID" value="KJY25054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25054">
        <property type="protein sequence ID" value="KJY25054"/>
        <property type="gene ID" value="VR44_33600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3627"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8083" checksum="C57CF7919BB1D872" modified="2015-06-24" version="1" fragment="single">EEYVEGALEPGMVLTVEPGLYFQPDDLTVPEEWRGIGVRIEDDLLVTADGHENLSAGLPRSADEVEAWMARVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU92</accession>
    <name>A0A0F4IU92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="6" type="ORF">VR44_33115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001107">
        <property type="protein sequence ID" value="KJY25214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951332.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3639"/>
    <dbReference type="EnsemblBacteria" id="KJY25214">
        <property type="protein sequence ID" value="KJY25214"/>
        <property type="gene ID" value="VR44_33115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3495"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023336262" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023336261" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23626" checksum="44038920EA774D5F" modified="2015-06-24" version="1">MPHSQTSAPRDSRLGVRLARGASPWLLPTVATAALSLTRARKSGRWAAVAVPTTALAAGMLWFFRDPEREIAQGRVISPADGVVQSIMPWKDGRTRVAIFMSPLNVHVNRAPLAGTVTSVEHIPGGFVPAFNKESENNERVVWHFDTELGDIEMVQIAGAVARRIVPYLPAGTKVEQGERIGLIRFGSRVDIYLPEGVEVAVEVGQATTAGVTRIDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUB2</accession>
    <name>A0A0F4IUB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001104">
        <property type="protein sequence ID" value="KJY25234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951321.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001104.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene109"/>
    <dbReference type="EnsemblBacteria" id="KJY25234">
        <property type="protein sequence ID" value="KJY25234"/>
        <property type="gene ID" value="VR44_33050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3482"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="22459" checksum="E274184A269245F2" modified="2015-06-24" version="1">MSGAEPVRRRRGPGRPRQDEAEEGPGTQERIRLAAREVFAERGYDKTSVRGIAKVAGVDPALVHHYFGSKDDLFAAAIEVTMEPALVVPAVVGEGPDGIGERLARYFLGVWENPATRAPLLAVIRSALTHEAAAKVLRGLILRRVLERVAADLDVPEPTFRAELAASHLIGIAFVRYVVQIEPLASADPEEIVALVAPTLQRYLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUE5</accession>
    <name>A0A0F4IUE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001043">
        <property type="protein sequence ID" value="KJY25635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951125.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25635">
        <property type="protein sequence ID" value="KJY25635"/>
        <property type="gene ID" value="VR44_31975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3111"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20077" checksum="5FA888E66176CBC3" modified="2015-06-24" version="1">MPEDPRTERTRAKLRTALLEECASRPLDAVSVAALVRRAGVGRATFYLHYADLEALSVDACAEIVREAVDALHAWRGVPDPAVPPPALTAFFDALPQHGGLYRELLRPGGGGPLGLVLHQDLRARSRAERALAGAPEPDLIASAVAATFAGILADWLHGLIEATPAEIAGRVWRLLIALHRAPGPDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUT7</accession>
    <name>A0A0F4IUT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ORF">VR44_31630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001025">
        <property type="protein sequence ID" value="KJY25777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951059.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25777">
        <property type="protein sequence ID" value="KJY25777"/>
        <property type="gene ID" value="VR44_31630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3034"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="25419" checksum="00084D0389BB3833" modified="2015-06-24" version="1">MDIVVKGRKTEVPERFRKHVAEKLNPERIQKLDAKVISLDVEVSKEHNPRQADRSDRVEITLRSRGPVIRAEAAAADPYAALDLAQDKLEARLRKQHDKRFTRRGTGRLSAAEVADSVPGVATLNGSGQPVGEETEDRIPTTRIGTLEVQGEGPLIVREKTHSARPMSLDQALYEMELVGHDFYLFVDAETKMPSVVYRRHAYDYGVIHVDPDGASSSEESAVGGAGGALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUU8</accession>
    <name>A0A0F4IUU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_32975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001100">
        <property type="protein sequence ID" value="KJY25258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951306.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001100.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3200"/>
    <dbReference type="EnsemblBacteria" id="KJY25258">
        <property type="protein sequence ID" value="KJY25258"/>
        <property type="gene ID" value="VR44_32975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3415"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="35"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="420"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="535" mass="57526" checksum="69CF5487233EA764" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV35</accession>
    <name>A0A0F4IV35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001067">
        <property type="protein sequence ID" value="KJY25484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25484">
        <property type="protein sequence ID" value="KJY25484"/>
        <property type="gene ID" value="VR44_32350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3271"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6777" checksum="31BF069750A7F23F" modified="2015-06-24" version="1" fragment="single">NAAIAKRAADHGFTFAPVVGAFTGHEICSGDAWLHSVNWTNIGESYHPTATGQSSGYLPVFSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVH1</accession>
    <name>A0A0F4IVH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001071">
        <property type="protein sequence ID" value="KJY25458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25458">
        <property type="protein sequence ID" value="KJY25458"/>
        <property type="gene ID" value="VR44_32460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="50" mass="5688" checksum="147CD57689CD5D6C" modified="2015-06-24" version="1" fragment="single">MKLTLRVWRQQNADAPGAMASYEVDGISKDMSFLEMLDTLNEDLILRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVZ4</accession>
    <name>A0A0F4IVZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001157">
        <property type="protein sequence ID" value="KJY24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24861">
        <property type="protein sequence ID" value="KJY24861"/>
        <property type="gene ID" value="VR44_34150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3757"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15067" checksum="BC7B75584AC7D49E" modified="2015-06-24" version="1" fragment="single">LALPACAGAVAVLAAAGLRRPPGRMRAGCLGAATAVCYALTAALMKSAVHILRGGGIGAFLTAWETYAFGAAGICAVLLLEHAMQGGPLVASQPALTLGDAGVSVALGVLLYEEHLRTHWWLLPQLLGLALICAGVLALARSDAGAEAGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW16</accession>
    <name>A0A0F4IW16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Streptogrisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_31935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001041">
        <property type="protein sequence ID" value="KJY25648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951117.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25648">
        <property type="protein sequence ID" value="KJY25648"/>
        <property type="gene ID" value="VR44_31935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3102"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469864" evidence="7">
        <location>
            <begin position="33"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="112"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY25648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="29562" checksum="1FAAFB36C3B125AB" modified="2015-06-24" version="1">MRTNSTTRLRLLAVATGLAAVAAIAAPTAASADPADTGFSAARLAAAGASVLRADVAGTAWHTDAATGTLVVTADSTVTDADLARIRREAGPDAAALRIERTPGKIRKLLSGGDAIYATSWRCSLGFNVRSGSNYYILTAGHCTDGAGTWWTSSSHTTTIGTTVGSSFPTNDYGLIKYASNSPVPPGTVGSQDITSAVNATTGMSVTRRGSTTGIHGGTVTGLNATVNYGNGDIVYGMIKTNVCAEPGDSGGPLYSGTRAVGLTSGGSGNCSSGGTTFFQPVTEALSAYGVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWC9</accession>
    <name>A0A0F4IWC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000952">
        <property type="protein sequence ID" value="KJY26332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6951"/>
    <dbReference type="EnsemblBacteria" id="KJY26332">
        <property type="protein sequence ID" value="KJY26332"/>
        <property type="gene ID" value="VR44_30250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2460"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="127"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="31828" checksum="1E51119A9FB53B4C" modified="2015-06-24" version="1" fragment="single">ERADAHDLVDTPTRVLGLATRTALDTAELPLALRQLLGRCTIHSIPATTLSGRPNTGGDAPVEGVLEATVMRLRDPSGGAITVERPYLPFTPTEFARARALVDLDARLGPRVPRSQDVLTLPEGNEITVRRADGTDLAAARAMHDRCSDRTLALRYHGPVADADRYLGHLLSPRFGRTLAATTASGRLVALGHLLWDGDETEVALLIEDDWQRRGIGSELLRRLLAMAVEAGSDSVYAVTQASNTGMVAAMRGLGLPLDYQIEEGTLVITARLEPAKALRRPESGLRQEKKPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWM7</accession>
    <name>A0A0F4IWM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001124">
        <property type="protein sequence ID" value="KJY25081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951411.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25081">
        <property type="protein sequence ID" value="KJY25081"/>
        <property type="gene ID" value="VR44_33495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3579"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="22440" checksum="05973A67F3890F9A" modified="2015-06-24" version="1">MRVERAAERSSERARAGAPSGSSALTRSRVRLDQPRQDRRKLLPEYDPEAFGRLSERVARFLGTGRFIVWMTLVIVVWVLWNVFAPDHLRFDQYPFIFLTLMLSLQASYAAPLILLAQNRQDDRDRVTHEQDRKQNERSIADTEYLTREIAALRMGLGEVATRDWIRSEFQDLIKEMDERRLFPGESDEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX34</accession>
    <name>A0A0F4IX34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">VR44_29725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950713.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7405"/>
    <dbReference type="EnsemblBacteria" id="KJY26572">
        <property type="protein sequence ID" value="KJY26572"/>
        <property type="gene ID" value="VR44_29725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2322"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="476"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="539" mass="56632" checksum="559A69DD36499E1E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX50</accession>
    <name>A0A0F4IX50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_29635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000917">
        <property type="protein sequence ID" value="KJY26620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950695.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000917.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26620">
        <property type="protein sequence ID" value="KJY26620"/>
        <property type="gene ID" value="VR44_29635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27098" checksum="D6CF60ABED1FA067" modified="2015-06-24" version="1" fragment="single">MSPVDSTALVTVLAAAAATALAVMLLTFAVALVKGVHRIVDSAWGLAFAAVAVVAWSLSAGHGDPVRRTVVALATVVWGLRLAVHIARRGRGHGEDPRYARMLARAPGSTALYALRTVYLLQGSLVWVVSLPVQVAVLLPRPLDAAAAVGLVLWAVGLFFEALGDHQLARFKADPANEGRIMDRGLWAWTRHPNYFGDFLLWWGLYLTACATWQTAAATVVSPLLMSALLIKGSGKRLLEAHMAGRPGYAAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX58</accession>
    <name>A0A0F4IX58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000967">
        <property type="protein sequence ID" value="KJY26234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950864.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000967.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000033_gene6728"/>
    <dbReference type="EnsemblBacteria" id="KJY26234">
        <property type="protein sequence ID" value="KJY26234"/>
        <property type="gene ID" value="VR44_30570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2532"/>
    <dbReference type="eggNOG" id="ENOG5030DSB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="28601" checksum="28F34125A0209E16" modified="2015-06-24" version="1">MSEWLVLTLAMAAACAVVLSIAFFNHRRITEDDDPDETPDVIEYMTMMIGVIYAIVLGLAIAGVWEGRGAAQEYVRQESQALHEISVRSEVYPAEVRKRIRSDVDAYVTYVVDTEWKHMSQQNEITDRSAELLEKIRRDVTDYEPQTDHEGQAYQPLVDQVALVDDARNARGESAGATMPGVVWFGLIAGALVTVGMIFTLQIRRSFRELLLAGLFSALIAFLLFLIWDFDAPFGRGIAATAEPFLTQFPHLGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXF4</accession>
    <name>A0A0F4IXF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000952">
        <property type="protein sequence ID" value="KJY26334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950809.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000952.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26334">
        <property type="protein sequence ID" value="KJY26334"/>
        <property type="gene ID" value="VR44_30260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2462"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470358" evidence="2">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="17982" checksum="D9D88B50CF47E245" modified="2015-06-24" version="1">MTTTNTTTAPATANPVLRVPPATPAAAAAYFAASLAFHADVSDVAAAFKAHREQGADLGFQLIDSRSTPSWDQAHVPGAIHLPTALIPEQAEKLLDKNVPVVTYCWGPGCNGGTRSALALAELGFQVKEMLGGIEYWIREGFEVETWQGTQQRAEADPLTAPTDSDDCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXI7</accession>
    <name>A0A0F4IXI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000948">
        <property type="protein sequence ID" value="KJY26369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950800.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000948.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26369">
        <property type="protein sequence ID" value="KJY26369"/>
        <property type="gene ID" value="VR44_30215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2450"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046185">
        <property type="entry name" value="DUF6213"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19719">
        <property type="entry name" value="DUF6213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="8956" checksum="EECCEB902DE5359A" modified="2015-06-24" version="1">MNAYVPLVSVADGGLLIPADEVTALLRRLAGGWLHSVYDGETDLDPGTTLGLANVLVELADQIDVECIGFMPLADEDPDATGPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXP7</accession>
    <name>A0A0F4IXP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000900">
        <property type="protein sequence ID" value="KJY26820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950600.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000900.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26820">
        <property type="protein sequence ID" value="KJY26820"/>
        <property type="gene ID" value="VR44_29115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2162"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470232" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16678" checksum="C02CFF39CD873540" modified="2015-06-24" version="1">MLKKIAAMGAAGVLCWGLNTAPASAAATMEYVHIESVADVGECLDYRSDWGPYTTTCNEGAYQTWLMSPYAETETELRQNAGARLCLVARNGVPVMRDCIAGDQAALWTLHDGGGAGWQLVNKATKTCLVAGSDDHHRVGMNTCSTGGSRSWILYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYI9</accession>
    <name>A0A0F4IYI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000871">
        <property type="protein sequence ID" value="KJY27090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27090">
        <property type="protein sequence ID" value="KJY27090"/>
        <property type="gene ID" value="VR44_28460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2017"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="49" mass="5541" checksum="96C4ACFB8F08AF68" modified="2015-06-24" version="1" fragment="single">MNDNIWAYHLAVALFEDRDLTGYKVEALDGAIGKVDKHSYETDASWIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYV1</accession>
    <name>A0A0F4IYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_31445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001018">
        <property type="protein sequence ID" value="KJY25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951023.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25851">
        <property type="protein sequence ID" value="KJY25851"/>
        <property type="gene ID" value="VR44_31445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2780"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="490" mass="49993" checksum="825F3CD67809A585" modified="2015-06-24" version="1">MTASPAAVGSRSHRAVLLTVTCLGQFMVLLDNTIVGAALPDMQGRLHTQLTGLQWIVDAYVLLVAMLLLSGGVFADRFGRKRVYLTGVAVFTAASVLCSLAPSLGWLVTGRVLQGIGAAALSPASLALLAAAYPVPRERVKAIGLWAGLSGIGLAAGPVAGGALTDAFGWPAIFLVNLPIGVVLLLAGLRSLEETRNPGAPAIDVPGTVLSVLGVGTMTYGLIEGGARGWTSPPILGSFTAALILLAAFVAVEARRSAPMLPLRLFRQRLFTVSNTAMVVVGFALMGSSFFFSQFFVYVQGSSVLGAGLRTLPLSLAMVVVSPYAGRLAARYGYRVVVTTGLALAGLGLLALGMVHADTGYGNVWWRLATVGTGFALTMSPLTGAAIQAVSAQEGGLASGISSTTRQIGAVLGVAVLGAVVRTRQADGASFETGLDNAFLAAGAVTLAAAVFTGLWLTRSKAAEGSTAPQAATAPRPATTSDEASANSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ79</accession>
    <name>A0A0F4IZ79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">VR44_28805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000883">
        <property type="protein sequence ID" value="KJY26944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950543.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000883.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26944">
        <property type="protein sequence ID" value="KJY26944"/>
        <property type="gene ID" value="VR44_28805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2101"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="8682" checksum="69CB84F47EA54170" modified="2015-06-24" version="1">MANDDVFDRLTTCAVDVLQVKAESVTPDANLTEDLGSSSLILVELVMAIEEEFGISVPDEAVEDIHTVEDLHRLILSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0B4</accession>
    <name>A0A0F4J0B4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">VR44_26960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000805">
        <property type="protein sequence ID" value="KJY27710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950208.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000805.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5236"/>
    <dbReference type="EnsemblBacteria" id="KJY27710">
        <property type="protein sequence ID" value="KJY27710"/>
        <property type="gene ID" value="VR44_26960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1554"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="27950" checksum="0FA6DE4084A0D41A" modified="2015-06-24" version="1">MSTGNIQLLSDTLAKARSEDRAALVAYLPAGFPTVDGGIEAVKAVIAGGADVVEIGLPHSDPVLDGAVIQTADDIALRGGVKIADVMRTVREAYEATGVPILVMTYWNPIDRYGVERFTAELAAAGGAGCILPDLPVQESDLWREHAAKHGLATVFVVAPSSKDERLATITAAGSGFVYAASLMGVTGTRESVGQEAQELVRRTRATTELPVCVGLGVSNAAQAKQVAGFADGVIVGSAFVKLLLDAPDLSAGLEAVRALAGDLAEGVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0L2</accession>
    <name>A0A0F4J0L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000794">
        <property type="protein sequence ID" value="KJY27820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950163.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000794.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4830"/>
    <dbReference type="EnsemblBacteria" id="KJY27820">
        <property type="protein sequence ID" value="KJY27820"/>
        <property type="gene ID" value="VR44_26710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1501"/>
    <dbReference type="eggNOG" id="ENOG502ZPJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19599" checksum="2D93112286BB6425" modified="2015-06-24" version="1">MEMPRSERSQDSPPHVLIVGQDGKAVGGADDESREVPVTEMVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRVRLKDIHAASVKELEDGLAPELVEELERLSLPFTEEAVPSEAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRRALPPGGPHEDDEDGPHGAIRSGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J194</accession>
    <name>A0A0F4J194_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000910">
        <property type="protein sequence ID" value="KJY26696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950663.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000910.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26696">
        <property type="protein sequence ID" value="KJY26696"/>
        <property type="gene ID" value="VR44_29455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2257"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="17978" checksum="81FF3CB6D4E42028" modified="2015-06-24" version="1">MTLSALDLALVEEASKKSGLIWVRGAGADRALWHAWVDGAAHVLGDGPGEQPFPGLADGAAAEVTVRSKDKGGRLVAWTAAVRELAPGSGPWEAAVAELKGKRLNAPDSEQMTERWARECRLLRLEPVAVADRLPEGSLAAAPLASSAITRRPVPAGLPKLLLKRKKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1M8</accession>
    <name>A0A0F4J1M8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000811">
        <property type="protein sequence ID" value="KJY27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950245.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000811.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27638">
        <property type="protein sequence ID" value="KJY27638"/>
        <property type="gene ID" value="VR44_27150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1619"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="679" mass="72716" checksum="D279C3540EA02813" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2S9</accession>
    <name>A0A0F4J2S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000723">
        <property type="protein sequence ID" value="KJY28520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949874.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000723.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28520">
        <property type="protein sequence ID" value="KJY28520"/>
        <property type="gene ID" value="VR44_25175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1128"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="40460" checksum="313B0C4F2DCAB350" modified="2015-06-24" version="1">MITTAPGTALLLAAAPTGKSRLIDATRVLPTLAACPPASLTRTTAGTVVELADPVDQQTVLTRIRAAAAAPGPLTLILAGQLQLDTRQNEIHLALARATPSTLRYTGLPWAWLASELKPRRPGTTTVLVDLVAAPSTWQTIRTHGLTLGHGISLYGRIAPSLPRHRIAAPTYLQAVAGIWRSGLTPPLAELHAKAAAQVGHDEALLLAMDFTPEPLPTPKAPLATTTADPLPAILAAAHAGHHDQAASLAVTWEGWAERTYGPGSAQAIHWLEVRADLAHIAGDTARSCELWMAAGQARLTRHQAPDAPEVEAAVDRAHHQWQQVRDPRRARELGPRLVGLRRRVPGQRAGAMEAVQRRLELLHTMPQALTAGSGGSGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3A3</accession>
    <name>A0A0F4J3A3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_27740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000842">
        <property type="protein sequence ID" value="KJY27386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M04.017"/>
    <dbReference type="EnsemblBacteria" id="KJY27386">
        <property type="protein sequence ID" value="KJY27386"/>
        <property type="gene ID" value="VR44_27740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023153849" description="Neutral metalloproteinase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="11">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="230"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY27386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="417" mass="42612" checksum="C6B1E9F6D838C49D" modified="2015-06-24" version="1" fragment="single">MKSTHRRNATATGALLAAAALLTVGVQAGSASAQPGGSANAAAPKGQPVRNPGALPAQLTPSQRADLIAKAQATTAATAKELGLGAQEKLVVRDVVKDQDGTTHTRYERTYEGLPVLGGDLVVNRTAADRTQSVSKASNAQLQGISTAAPADAPAAASAKALDAAKAAGSKADKADAAPRKIIWMAKGVPTLAYETVIGGLQDDGTPNQLHVITDAKTGAKLHQWQGIETGVGNTHYSGQVTLGTSKSGSNFVLTDTGRGGHKTYNLNHGTSGTGSLFSQTTDTWGNGANSNAATAGADAAYGAGVTWDFYKNVFGRAGIRGDGVAAYSRVHYGNAYVNAFWDDSCFCMTYGDGTNNNDPLTSLDVAGHEMSHGVTAATAGLEYSAESGGLNEATSDIMGTSVEFYANNPSDPGDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3B3</accession>
    <name>A0A0F4J3B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28735">
        <property type="protein sequence ID" value="KJY28735"/>
        <property type="gene ID" value="VR44_24715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.940"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="44597" checksum="15EAA1691BE6AAA9" modified="2015-06-24" version="1" fragment="single">WEPVARHTETITVAGAEDVEVEILETARGPVIVNEDSRALSLRYPPRVRADLGFAALPALLRARTVADVDRALDGWAEPVNVVHAADSEGGLLHRVAGAVPLREAANRLRPVPAWDARHAWRGWAETPAEPVRGFAVMANARGIASPLGVEFAPPHRADRIRALLSDSADWSPKAMADVHRDTHLASAAPLLALLPGLEPLSPAAARLRDRLLDWDRRMEADSTDAAVFASFRTAVVRRLAADPVFAELAGAPDGPEVFHPWLYLIPRVGYALEGLLTTHLLPGLDRAAHVRAALEETAAAEAPEAPWSDSHRLTPWQAVPDPDAEWPGLGGDHDCVNATSSVPGVTDTVARASAARYVWDLADRENSLWAVPLGADGVTGSPHHRDQLPLWARCELVPVVTDWTRLTKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3E4</accession>
    <name>A0A0F4J3E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000702">
        <property type="protein sequence ID" value="KJY28785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949764.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3004"/>
    <dbReference type="EnsemblBacteria" id="KJY28785">
        <property type="protein sequence ID" value="KJY28785"/>
        <property type="gene ID" value="VR44_24580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.911"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="369"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="412"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="703" mass="76765" checksum="8ED306B4645739BD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Y3</accession>
    <name>A0A0F4J4Y3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CdiI_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949713.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28884">
        <property type="protein sequence ID" value="KJY28884"/>
        <property type="gene ID" value="VR44_24305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.842"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041129">
        <property type="entry name" value="CdiI_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18593">
        <property type="entry name" value="CdiI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdiI_2" evidence="1">
        <location>
            <begin position="127"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="25136" checksum="6B2B973BB411B4C4" modified="2015-06-24" version="1">MSMKPLEFDRRYGELDQVISAYAGQSADDTPDRPGRALTAYLRHTWHTRPWALSVAEQQLRAYAENPPGRLRHRLGEFYPVPDIGLPEAEIQQWLLVLADHIRWSIEEGRVPAPVALPETHWEWHARFPELGQFLGGWFSQDMPDEFDDHDTAVRDYADSADPTLVARVVGEVRELLALGLEEVDYAVGVAELGMEVDPPAPYAPSGWLAVVAERLAGPRAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J571</accession>
    <name>A0A0F4J571_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_22840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000640">
        <property type="protein sequence ID" value="KJY29482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949445.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000640.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29482">
        <property type="protein sequence ID" value="KJY29482"/>
        <property type="gene ID" value="VR44_22840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.501"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="60"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="29122" checksum="0954584F1A77FA90" modified="2015-06-24" version="1">MTSRLTRRQRRRVWQGVQYAVFVAVVVLVGVTADWDRLQNQFAQKDLVARLFPEIITTALRNTVVYTFSGFAFGLVLGLVIAMMRLSSVAPYRWVATVYIELFRGLPALLIFIFVGVAVPLAFPGTEIPGGTYGKVALGLGLVAAAYMAETIRAGIQAVPKGQMEAARSLGFSHGRAMAFVIIPQAFRIVIPPLTNELVLLFKDSSLVLFLGVTLEERELTKFGRDLASETANSTPILVAGLCYLLVTVPLSFVVRRLEARADKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6I6</accession>
    <name>A0A0F4J6I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000613">
        <property type="protein sequence ID" value="KJY29825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29825">
        <property type="protein sequence ID" value="KJY29825"/>
        <property type="gene ID" value="VR44_21960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.272"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="9754" checksum="35C55A8DD9BFAFDC" modified="2015-06-24" version="1" fragment="single">MCCTAAAALTGCGGPARDGYAAVGAAAPGPERGAGQNVPPQGRVEFQPIASAGSAPSASASASTTPGAPGSLPGGGSAQGGATATAQGGSDPAPGTPPAPGTPTTTPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J702</accession>
    <name>A0A0F4J702_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000587">
        <property type="protein sequence ID" value="KJY30152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30152">
        <property type="protein sequence ID" value="KJY30152"/>
        <property type="gene ID" value="VR44_21090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8941"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16223" checksum="18C706EB0B07C8F5" modified="2015-06-24" version="1" fragment="single">MWFDSGRVCLDLLATRTPQGAEAIHDGDELRLWLVGAGLVPDRTPLGRLGPDWVEAFRRLRRDVDSLVRAELAGSAPEEDALARVNAAAAGPPPGVCAVRDREGHLVRELCGGVECAGLLATVARDAVELLTDPGDLALLRSCGGDGCARLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7A3</accession>
    <name>A0A0F4J7A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_22290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000624">
        <property type="protein sequence ID" value="KJY29689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29689">
        <property type="protein sequence ID" value="KJY29689"/>
        <property type="gene ID" value="VR44_22290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.345"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="411" mass="44650" checksum="7163D72A999193D6" modified="2015-06-24" version="1">MRGRGALLGIAGIWLATRAAMLWMLVHDFFSSNVVRVEVTATYHNWYNVLVHWTLPHNDIMWQYPPAAAAIFLSPDLLPFLTYFQAFVALTVLCDGVVLLGLIRAARRSDGSMAGALVWLVTLPMMMATPFARYDIQVTLLAVFALLAMRHRPKAAGVIAGIGAMVKVWPLLTLLGTPRGKSTRDAVVAAVLSAAGLLAVFALLFKDTLGFLGNQGDRGVQIESLGGSALMAARLVDLWPGKVNFQYGAFEYVGPYVSTIARASLGLTVVGFLLLLLWRVKANRWSSATPFDAALCAIMVFTVTSRVISPQYMIWLLGLAAVCLTSKNTTQRPIAWLLVAANALTTLIFPICYGSDILTNSTLGTVLLCTRNGLLLYATVWSGVRLWKATVLPKSLPQQAREAELRAPQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7B4</accession>
    <name>A0A0F4J7B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000699">
        <property type="protein sequence ID" value="KJY28831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28831">
        <property type="protein sequence ID" value="KJY28831"/>
        <property type="gene ID" value="VR44_24405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7060" checksum="D0A299F38FB32774" modified="2015-06-24" version="1">MRLDSVSHAVRAGLGASVFTSASDSPGWEMPAMTWSGNALPSARSQRDLGRLITRIDEDFVAVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7F9</accession>
    <name>A0A0F4J7F9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_24220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000695">
        <property type="protein sequence ID" value="KJY28891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949698.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000695.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2966"/>
    <dbReference type="EnsemblBacteria" id="KJY28891">
        <property type="protein sequence ID" value="KJY28891"/>
        <property type="gene ID" value="VR44_24220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.824"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="456"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="529" mass="55036" checksum="D6B9C2E9080D7CD1" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7S8</accession>
    <name>A0A0F4J7S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000565">
        <property type="protein sequence ID" value="KJY30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949013.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000565.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30427">
        <property type="protein sequence ID" value="KJY30427"/>
        <property type="gene ID" value="VR44_20525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8815"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="26921" checksum="1BB3490AB47E925F" modified="2015-06-24" version="1">MTFVQVIDYETTRFDEMNALIDRYAEQTSGKRTVTHTMIGKDRDSQTHYVDLVEFPSYEEAMKNSQLPETDRMFQEMVALCEGMPKFMNLDVVRDEYLNKLVVNRMFEECILKGDFAVLDECLAMNYKDHDIMESEGQSDGRDGMRQTITMWRDAFDFSFDQTRQIAEGDCVTTLWNWKGTQKGEFMGVAPTGKEVTMSGCTTFRLENGSIAEGWWYYDAPSLMRQMGMMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J802</accession>
    <name>A0A0F4J802_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000680">
        <property type="protein sequence ID" value="KJY29066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949627.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000680.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29066">
        <property type="protein sequence ID" value="KJY29066"/>
        <property type="gene ID" value="VR44_23850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.743"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22870" checksum="964E304544D5579E" modified="2015-06-24" version="1">MTPRPEDPSDTEAPEAPGGAEELPAVAPQLRELRRRAGLTLEAAAARARLSPAHLSRLETGRRQPSLPLLLGLARTYGTTVSELLGETPAVADPIVRAGGPGAREADGWTYWQAGGSGRGMQALRVHVPPGRSQGELVRVHPGEEWLYVLGGRLRLHLGEAEHLLEPGDSAHFDSLTPHRIGAAGPGGAELLFVHTLLQSSLAGVCLGGTAKHHPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8E1</accession>
    <name>A0A0F4J8E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948992.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000562.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30455">
        <property type="protein sequence ID" value="KJY30455"/>
        <property type="gene ID" value="VR44_20400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470700" evidence="1">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26228" checksum="22E4666AC8004DF6" modified="2015-06-24" version="1">MRHQGRIRKWLAAAAGAAALLSALPGPAATAAADEVRPLAGNILNLHQCVYQPTPGVDYLTTLVPSLDGRFAAGTNISAAPDRALSCGGGDGNYTPVFPWASLESLDLGSGRYLNLHQCVYYSDLQHDHLTVIVGGRGSEWSAGTNVSNTPDTQVSCGPGRGLYYLVPLLSSVKALDLTAGRYLNLQQCQYYFSRLTDHFTTFLPSGDGRFATGTKISGTADTTPTCGSGDGNYTLIPLLSGTKALSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8E8</accession>
    <name>A0A0F4J8E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6642"/>
    <dbReference type="EnsemblBacteria" id="KJY30460">
        <property type="protein sequence ID" value="KJY30460"/>
        <property type="gene ID" value="VR44_20425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8795"/>
    <dbReference type="eggNOG" id="ENOG50330PX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6603" checksum="7FD8B45056A9BCE3" modified="2015-06-24" version="1">MCQHQPACPSSDSADREAARPVANHPEQGWSLLCNGVLLFEDTGELLPDGKIIAPHRPLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9J6</accession>
    <name>A0A0F4J9J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31032">
        <property type="protein sequence ID" value="KJY31032"/>
        <property type="gene ID" value="VR44_19025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8409"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="10168" checksum="618E54E1288964FB" modified="2015-06-24" version="1" fragment="single">MSILIESTYVCWRHERPPVRHPLRRRLGALFRRSRGGPPPPDHHSGGRPAPRREAGDRVRVRQPWPARQPPRPGGARQHLRRRRGGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9U8</accession>
    <name>A0A0F4J9U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tuf</name>
        <name evidence="8" type="ORF">VR44_20260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948964.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6970"/>
    <dbReference type="EnsemblBacteria" id="KJY30518">
        <property type="protein sequence ID" value="KJY30518"/>
        <property type="gene ID" value="VR44_20260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8759"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="41380" checksum="027A0DC26C7672E3" modified="2015-06-24" version="1">MAKTAFARTKPHLNIGTMGHVDHGKTTLTAAITKVLAERGGASFVPFDRIDRAPEEARRGITINLTHVEYETDTRHYAHVDMPGHADYVKNMVTGAAQLDGAILVVSALDGVMPQTAEHVLLARQVGVDHIVVALNKADAGDPELTDLVELEVRELLSAHGYGGDEAPVVRVSGLGALEGDPRWTGAIEALLDAVDTYVPMPVRYTDAPFLLPVENVLTITGRGTVVTGAVERGTVRLGDRVALLGGDGEPVETVVTGLETFGKPMESAEAGDNVALLLRGVHRGDARRGHVVAAPGSVAPRRRFTARVYVLSAREGGRTTALSSGYRPQFYIRTADVVGDVDLGGAGVARPGETVTMTVELGRDLPLEAGLGFAIREGGRTVGAGTVTEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9X3</accession>
    <name>A0A0F4J9X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000617">
        <property type="protein sequence ID" value="KJY29776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949310.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000617.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29776">
        <property type="protein sequence ID" value="KJY29776"/>
        <property type="gene ID" value="VR44_22105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.302"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="45121" checksum="9A7438172BE811B5" modified="2015-06-24" version="1" fragment="single">PWRRIEHTMESGGRLFFAGPEERRLEVARLRRTHRRIHGTDTAGRSYSAEDPAVRGWVMVTLYESMTAMRELSGEPLAPAERDLLYAEFLDVCAALGIPGEVLPASAAEVPAYVERTVREVLEFGPEVRHMLHGVLREAPAPRRLGRLAPVWPLLRVVIARAVAALTVSDLPPAWHERFGTSRGPGGAALSWALHHGLRHAMALAPGRVRYRRRSVSGAPAPARGAVPRARRGGDSRPARLEAFFRQVLDQTGNGRVDSADLQAMVHTMCWRLELPAEREDEVYAAFEGWWRQLRATADADGDGAVDCGEFVSAMLAGVERDPAYLEKGLVPAVRALFRAADADGSGYLGADEYRLLFGGPRVHPADLNDGFRELDADGDGRVDEQEFVAAFCDFFAARTDSTAGTGLLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA42</accession>
    <name>A0A0F4JA42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000521">
        <property type="protein sequence ID" value="KJY31050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948738.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000521.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31050">
        <property type="protein sequence ID" value="KJY31050"/>
        <property type="gene ID" value="VR44_19020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8408"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="37375" checksum="0236C157720FB638" modified="2015-06-24" version="1" fragment="single">RRSRREAAGPPAGELAVRTALTLIEPETDRYWFRGVDAVELASRYAFEEVAEWLWTGTAAPGARFAAPAELLAAARRAVAAMPEHSGPLDLLRVAVAAAAVADPLRFDLSGEAVLGSARCLIPTLVGALPEAAPEHPGDGRLAWRLWSRLTAREPDPVAVDALDLALALLVDHDLAASTLAVRVAASARAHPYAVVSAGLGALEGPLHGAAGRLAHRMLAEVLERGGAAPVVAEYLRAGRRMPGFGHRLYRGEDPRARALSGRLAELPPAAAALGAAREVAAVMARHGLHPNVDLALAVLTLSSGMTAEAGETVFAVARTAGWIAHALEEYQERPLRMRPSGHYTGRRPPRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAE8</accession>
    <name>A0A0F4JAE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31347">
        <property type="protein sequence ID" value="KJY31347"/>
        <property type="gene ID" value="VR44_18290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8206"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="39" mass="4414" checksum="323D0266EEEEE988" modified="2015-06-24" version="1" fragment="single">SRLYLSEGTVKNHISRVLSRLGLRDRTQAALYARDNGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB48</accession>
    <name>A0A0F4JB48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948577.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31415">
        <property type="protein sequence ID" value="KJY31415"/>
        <property type="gene ID" value="VR44_18145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8176"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="28494" checksum="C0E8D53A00753A3E" modified="2015-06-24" version="1" fragment="single">MRAVVVDGFGGPEQVRVAEVEVPRPAAGQVRVRVRAAGVNPVDGAVRAGVFGGAGQRIGLGWDVAGEIDEVGPGVEGWTPGSRVVGLHYGTVKPLGTHAEYAVLDASAVAAAPESVDAAVAAALPLSGLTAARALDLLGLGAGESVLITGAAGSVGGIAVQLAARAGLVVTALAGEGDEELVRSLGAKEFVPRGAEPAGPVDGVLDAAVLGAAALGFVRDGGAYVGLIPGAAPAAERGVRVVEQEVAADGAELGRLVGLVDAGELTLRVGRTFGLAEAAEAHAVLAAPGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBW6</accession>
    <name>A0A0F4JBW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000461">
        <property type="protein sequence ID" value="KJY31857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31857">
        <property type="protein sequence ID" value="KJY31857"/>
        <property type="gene ID" value="VR44_17275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7990"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470305" description="MFS domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="198"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="36881" checksum="02EA57A51CB49FAF" modified="2015-06-24" version="1">MRLAVCAVFFVTGAAFATWAARVPAVQSRLDLSAGELAVALVGLSGGAFLGLPLVGGLVARYGSRRVLCAGLIAYLGALASLPHVPDLAVLTAALALFACGNTAVDVAMNTQGVLVERAYGRPVLGGFHAMFSLGGITGAAAGGLAASAGVGIAAHFTVAALVLLAVAGAAATALAPDPPPAAGPSRRDPLLALPGPGLWIPGLVAFCALMGEGVVNDWGAVYLKEETGASAGAAGLGYAVFSAGMVVGRLTADRLRARLGTVRFTLLCAAVAGAGALIPILDATTAAGFVGYGLLGLGMAAVIPLVFAHAAGLRPERAGSSIAAVSAVGYVGFLAGPPVIGALAEATTLRWAMLVLPALMAAMAVLAGRLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCF1</accession>
    <name>A0A0F4JCF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31474">
        <property type="protein sequence ID" value="KJY31474"/>
        <property type="gene ID" value="VR44_18030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8152"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13806" checksum="AFCD51985BBB683C" modified="2015-06-24" version="1">MFGMAWAVVDFWIDPFTVGFPKDCVRGPRGGCLTNTFTFRWASGVTLFLLVVPTLVVAIMGLVTDRWPPAVGLALGSVGGGILVLSHGGTTAHVSCAVLLFALAATALALVGGRKLGSAYRRSREDWLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCZ1</accession>
    <name>A0A0F4JCZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_16810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948325.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000445.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5411"/>
    <dbReference type="EnsemblBacteria" id="KJY32065">
        <property type="protein sequence ID" value="KJY32065"/>
        <property type="gene ID" value="VR44_16810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7797"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="67"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="353"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="731"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="829" mass="91403" checksum="393C5EAD586B39AC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDB0</accession>
    <name>A0A0F4JDB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000472">
        <property type="protein sequence ID" value="KJY31733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948469.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000472.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31733">
        <property type="protein sequence ID" value="KJY31733"/>
        <property type="gene ID" value="VR44_17625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8090"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="20968" checksum="4607E653A8953A6A" modified="2015-06-24" version="1">MDPPPPAGSALWQGHSPGDGAVYLDPCGLGNGIADGDNLAGAGRAFWAQNPPAAAVDPAVLAQRAVDSMLLRPPAIGIVPKPGGVGVVGMPVYMWTATGPETYGPNVASASAGAVTVTATARVAKIVWAMGDGTTVTCTTPGTPYQAQFGKNPSPDCGHSYRTPGKYHVTATSTWAIDWTGGGQSGQLTEVRSSAVDIAVGEVQVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDN8</accession>
    <name>A0A0F4JDN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000418">
        <property type="protein sequence ID" value="KJY32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948195.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000418.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32330">
        <property type="protein sequence ID" value="KJY32330"/>
        <property type="gene ID" value="VR44_16155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32499" checksum="CDDE70622BFF3E6A" modified="2015-06-24" version="1" fragment="single">MEPDKRPEPEAGPPAEQTAGPGRQVEEREPDRLSELPKRSWKAVLRGTLKEFKDDELADRAAALTYYGVLALFPALLVLVSLLGIAGDSATKQVMDNVQRLTPGAARDVIGNAVRQLQDNAGIGSLLAIVGILVAIWSASGYVAAFIRASNAVYDMPEGRPVWKVLPLRVGLTVVLMILAVTSALIVVFTGTLARQAGSALGVGDTAMTVWSIAKWPFLLVLVTVMIALLYWASPNAKGRGFRWVTPGSFLALVIWMIASAGFAFYVANFGSYNKTYGTLAGVIIFLVWLWITNLAVLLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEM1</accession>
    <name>A0A0F4JEM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000425">
        <property type="protein sequence ID" value="KJY32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948224.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32249">
        <property type="protein sequence ID" value="KJY32249"/>
        <property type="gene ID" value="VR44_16310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7716"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23210" checksum="3DA918C2F6788F8B" modified="2015-06-24" version="1" fragment="single">LADGRRELAEAAGSGSGSVTVASETLMTLAALLPGWRRARPGVDLRLRQCPADAMAHLLRTREADLCLASEPLAGPGLESVELLREEVLLAVPAGHRLAGREGVAVAELAGEPFLTPGPGHWQRELADRLFAREGLRPTVVCEGNEPGALLDLVGAGLGVALLPGMARDAGLRATVAWARLESPDSHRVLWLVRDREAFRPAAVRDFAAFAVAHFRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFS1</accession>
    <name>A0A0F4JFS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948104.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32603">
        <property type="protein sequence ID" value="KJY32603"/>
        <property type="gene ID" value="VR44_15675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7537"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10530" checksum="4F88EC28A8AE55ED" modified="2015-06-24" version="1">MKVTLETYGGLAAAVRRRPQTLDTSTLPETDAAELTRLVTTAEATPPPTGSDGLARDAMTYAITVEDNGGTTVLEQSDPTMTPAFAALLRWLKTHSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFU5</accession>
    <name>A0A0F4JFU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_14340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000370">
        <property type="protein sequence ID" value="KJY33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947863.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3336"/>
    <dbReference type="EnsemblBacteria" id="KJY33212">
        <property type="protein sequence ID" value="KJY33212"/>
        <property type="gene ID" value="VR44_14340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7217"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="117"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="736"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="814" mass="90504" checksum="C0C16824A358136E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFU7</accession>
    <name>A0A0F4JFU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000402">
        <property type="protein sequence ID" value="KJY32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948091.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000402.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32628">
        <property type="protein sequence ID" value="KJY32628"/>
        <property type="gene ID" value="VR44_15600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7426" checksum="A28E7F8FF4FF322F" modified="2015-06-24" version="1">MDMVGRTGRVTGVVGPGLVGEVILHIRGGAEHFLAYPALGERGRIGVGAVVTVVEYQPPRTVYVMEVYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFZ8</accession>
    <name>A0A0F4JFZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_14250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000367">
        <property type="protein sequence ID" value="KJY33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947848.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000367.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33267">
        <property type="protein sequence ID" value="KJY33267"/>
        <property type="gene ID" value="VR44_14250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7197"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="28552" checksum="647C2B8A166B1918" modified="2015-06-24" version="1">MSRTRAAVLGSPIEHSLSPVLHRAAYRELGLDDWSYDRFEIDEAALPGFVAGLGPEWAGFSLTMPLKRAVIPLLDEISDTAASVEAVNTLVLTEDGRRVGDNTDIPGIVAALHERGVEKVPAAAVLGAGATASSALAALARICTGEITAYVRSEARAEEMRGWGERLGVDVRTADWSRAAEALHAPLVIATTPAGATDELAAAVPAAPGALFDVLYDPWPTALAAAWSGRGGKLLGGLDLLVHQAVLQVERMTGRAPGPLAAMRAAGERALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK8</accession>
    <name>A0A0F4JGK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_14070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947819.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33355">
        <property type="protein sequence ID" value="KJY33355"/>
        <property type="gene ID" value="VR44_14070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7127"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16482" checksum="D210E26002486AEC" modified="2015-06-24" version="1">MSTPTRRAQLGQVFRFALVGGVNTGTFFGIYLLLHPWLPYFAAYTLAFLLSMVGSFFMNTYFTYRTRPTWKKFLLFPLTNVTNYVIQSAGLYALVTWAGMDTRIAPLVAAVVAIPFTFLLSRKILIPGTGAVTAPEPERAEERSASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH09</accession>
    <name>A0A0F4JH09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33475">
        <property type="protein sequence ID" value="KJY33475"/>
        <property type="gene ID" value="VR44_13880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7061"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="40460" checksum="5399BAC4E61B411F" modified="2015-06-24" version="1">MSRREETKADGEAVGRVVGLPSLTGLRWTAALMVFLYHVYIVEYFGGRAQGLVGAAFGVGNTGVSFFFVLSGFVLAWSAARTPTGWGVVRFWRRRFARVYPLHLVTAAAALVLVWLLGAGEKPAAGPVAANLGLVQAWVARVPYFQGLNPVSWSLAAEAFFYLFFPLFLWPLRRLGWRASAGAAAVCLTAVVALPAWMELSGLPDGAIWANMFFPLYRLPEFVLGIALAELVRAGRWRGPGLSVALALTMAGYFLSGQADYAYRAAACTVVGYAALIAAAAQADLRGEPSPWRGRLSVKLGEVSFAFYMVHILVIRAGESLFGGHPKLGLWGGLLATAAVFCVSLALAWALHVWVELPGRRLLLRSRRRGTPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIC0</accession>
    <name>A0A0F4JIC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947757.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33554">
        <property type="protein sequence ID" value="KJY33554"/>
        <property type="gene ID" value="VR44_13745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7026"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="775"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="817"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="859"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="901"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="943"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1393" mass="145989" checksum="4EC4E9B814F5AA09" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIY4</accession>
    <name>A0A0F4JIY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000311">
        <property type="protein sequence ID" value="KJY34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000311.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34150">
        <property type="protein sequence ID" value="KJY34150"/>
        <property type="gene ID" value="VR44_12510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6563"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470541" description="Amidase_6 domain-containing protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase_6" evidence="3">
        <location>
            <begin position="226"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="41551" checksum="BFA53B747AAFEBCD" modified="2015-06-24" version="1">MIPKRFRPAAIAALTVAVASGGFFAYSANAVSGPAEADQATTETFARLADDVLSQRTQALVEGQTVRHGHGQGGKKKARMSDGLKKDQDAAIQSLRDRKTRLAQLGEVYSGADTKVTVDRATVTGGKATVQVTEQTTLTYKKVHGDEPSTTDFKTRYELSLTSRKGGDWELQTIKSQENGPVAVNEPVAAKAAVVTDDGNQYPDGTPASTTYPATAKPKTLTGGAYNYTAMAQYAEKYWSNYNPAYRKFSGNGGDCTNFISQALNAGGWKPVPGTSTDYRNWWYDGTRQSDSWVGANEWAWFTLSNQRAANLANVYQLDVGDILQADFNRDGSKDHSMMVTYRSRAGMPYLTYHSTNTYRKSLASILASYPNARYFAYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJP3</accession>
    <name>A0A0F4JJP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000280">
        <property type="protein sequence ID" value="KJY34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947365.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000280.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3704"/>
    <dbReference type="EnsemblBacteria" id="KJY34557">
        <property type="protein sequence ID" value="KJY34557"/>
        <property type="gene ID" value="VR44_11640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6294"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="84"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="28143" checksum="5B4775433A8DFABC" modified="2015-06-24" version="1">MPTSSASTTDASAKPTAASGGVQSLERAFDLLERMADAGGEVGLSELSAASGLPLPTIHRLMRTLVACGYVRQQPNRRYSLGPRLIRLGESASRLLGTWARPYLARLVEETGETANMALLDGDEIVYVAQVPSKHSMRMFTEVGRRVLPHSTGVGKALLAHTPAEEVRALLARTGMPAATEKTITTPEGFLEALEQVRKAGYAVDDNEQEIGVRCLAVSVPNSPTAAAISISGPAGRVTQEVAESFVPILQGVAAELSVALQSQTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLL4</accession>
    <name>A0A0F4JLL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional F420 biosynthesis protein FbiB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Coenzyme F420:L-glutamate ligase</fullName>
                <ecNumber evidence="10">6.3.2.31</ecNumber>
                <ecNumber evidence="10">6.3.2.34</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-0:L-glutamate ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Dehydro-coenzyme F420-0 reductase</fullName>
                <ecNumber evidence="10">1.3.8.17</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">fbiB</name>
        <name evidence="13" type="ORF">VR44_10865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2</text>
            <dbReference type="Rhea" id="RHEA:60360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="1.3.8.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the CofE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="10"/>
    <dbReference type="EC" id="6.3.2.34" evidence="10"/>
    <dbReference type="EC" id="1.3.8.17" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947223.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene462"/>
    <dbReference type="EnsemblBacteria" id="KJY35075">
        <property type="protein sequence ID" value="KJY35075"/>
        <property type="gene ID" value="VR44_10865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6053"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052890">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="F420_ligase" evidence="12">
        <location>
            <begin position="81"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="11">
        <location>
            <begin position="241"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme F420:L-glutamate ligase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydro-coenzyme F420-0 reductase" evidence="10">
        <location>
            <begin position="232"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>coenzyme F420-(gamma-Glu)n</name>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="45363" checksum="28AB915153FC8333" modified="2015-06-24" version="1">MSTPSYEVRALPGIPEVRPGDDLARLIADAAPGLRDGDVLLVTSKIVSKAEGRIVRADSREEAIDAETVRVVARRGTLRIVENRQGLVMAAAGVDASNTEPGTVLLLPEDPDASAAALRDGLRTLLSVDVGVVVTDTFGRPWRSGLTDVAIGAAGVRVLDDLRGGTDAHGNPLSATIVATADELAAAGDLVKGKAAGLPVAVVRGLGHLVGGASSARDLVRAPADDMFRLGTSEAVREAVTQRRTVRAFTDEPVAPGAVRRAVAAALTAPAPHHTTPWRFVLLESAGARLELLDAMRDAWIADLRRDGKSEESIAKRVRRGDVLRNAPYLVVPCMVTDGAHDYGHARRDAAEREMFVVATGAGVQNFLVALAGERLGSAWVSSTMFCRDVVRKVLGLPETWDPMGAVAVGHPAGAPAERPGRAAEDFIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLM0</accession>
    <name>A0A0F4JLM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EcaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947164.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35242">
        <property type="protein sequence ID" value="KJY35242"/>
        <property type="gene ID" value="VR44_10545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5853"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14552" checksum="C4BF299A249CB8E7" modified="2015-06-24" version="1">MHTDSAARAADIEAIKQVVAVVEHSQQHKDPDEFLALFHPDAVWTTAGGKVLIGLDAISEFTRQVLPAADWDGKVTYEVLHVLFIRPDVAAVKVRQLYLSPDAGSEGAPLYVMSRQDDGRWLLTACQNTAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP59</accession>
    <name>A0A0F4JP59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946994.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35629">
        <property type="protein sequence ID" value="KJY35629"/>
        <property type="gene ID" value="VR44_09635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5375"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="SSF141066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12054" checksum="38B786F18B62CB42" modified="2015-06-24" version="1">MEVRRIVLGAGEAYALRLAGRGARGYVWTWQVSGNADAVAVRETGSGPAARLLPGEAVERTYEVLGRSPGGRARIRFAQVRPPYPQEAPYDEFVLDVEVVDAAGARRAVTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP72</accession>
    <name>A0A0F4JP72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947327.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34736">
        <property type="protein sequence ID" value="KJY34736"/>
        <property type="gene ID" value="VR44_11425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29806" checksum="DE181C55EE6D2063" modified="2015-06-24" version="1">MFTIGDFARHGRVSVRMLRHYDATGLLRPAHVDPHNGYRHYTAAQLARLNRIIALKDLGFTLQQVHDIVDEKVGAEELRGMLRLRQAELESAVAAAGARLVQVEARLRAIESEGRMSVDDVVIKNLPAVRVAELTATAESFGPEDIGPVIGPLYDELFRLLGAAGIIPTGPGVAYYEDAPEGGGRISVHAGVQVCAPLQDGPFRVLDLPPVEQAATVVHRGSMDTVLPTAQTLARWIDAHGYRSAGYPREINLECPENRDEWVTELQAPVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ52</accession>
    <name>A0A0F4JQ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium transporter KtrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000187">
        <property type="protein sequence ID" value="KJY35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35954">
        <property type="protein sequence ID" value="KJY35954"/>
        <property type="gene ID" value="VR44_08870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5021"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14690" checksum="792B455711EF4E63" modified="2015-06-24" version="1" fragment="single">GNMVDLDSNPTKLIDIVEIGKQLLITRGALTTFSITNDVAKYFAIIPAMFATAYPGLEALNIMGLSSPRSAITSAIIFNALIIVALIPLALRGVRYEPASAHDLLRRNLGVYGLGGLVLPFVGIKLIDLLVSLVPGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQF6</accession>
    <name>A0A0F4JQF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946638.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36592">
        <property type="protein sequence ID" value="KJY36592"/>
        <property type="gene ID" value="VR44_07730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4158"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7886" checksum="6D341DAF3463659A" modified="2015-06-24" version="1">MSAMQAAVTQLVPLAADTFDKNKVTPGLLGFIVFAALALGVWGLMKSMSKHMGRVDFEEAPEPAGATAAPAADGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQP3</accession>
    <name>A0A0F4JQP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946571.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36682">
        <property type="protein sequence ID" value="KJY36682"/>
        <property type="gene ID" value="VR44_07390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3951"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="40532" checksum="0EA60D411EFCAB9C" modified="2015-06-24" version="1">MSEPTEVRAAAPPRPPGAPEPAPPAGRSVAARATLAGTAVSLLLITAIVLGSRLLRDFDSALLPYAVATVFLAFGVAYRYTVWVSAPGARRLFKKGFGSFFSAANFKKAPTALPRMITTYLGFQKFLGARSRARWAAHQLIFWGCLLAAAITFPLTWGWFTFTSGSGSGPGYEMRIWGIKVLGFNSLNILGWLMFHGLDIAAVLVIPGASYFLWRRMKDRGAITGQRFAYDLLPLICLIVISVTGLLLTFSSIFLHGGGYEFLAILHMVSVVFTLIYIPFGKFFHIVQRPAAVGMQLFKYTARQDEQVFACKRCGEPIDTTPYVENLRGTMRDLRLDFNAFVEYCPRCKRILRGNAYLTHVKKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRE1</accession>
    <name>A0A0F4JRE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947090.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35486">
        <property type="protein sequence ID" value="KJY35486"/>
        <property type="gene ID" value="VR44_10165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5633"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470815" evidence="1">
        <location>
            <begin position="21"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="84"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="534" mass="57415" checksum="55F407378AB10AE0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRT8</accession>
    <name>A0A0F4JRT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosylmethionine synthetase</fullName>
            <ecNumber evidence="4">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35661">
        <property type="protein sequence ID" value="KJY35661"/>
        <property type="gene ID" value="VR44_09605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="3">
        <location>
            <begin position="125"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="25142" checksum="0D006202BBD443F3" modified="2015-06-24" version="1" fragment="single">MSRRLFTSESVTEGHPDKIADQISDTILDALLRQDPTSRVAVETLITTGQVHIAGEVTTKAYAPIAQLVRERILEIGYDSSTKGFDGASCGVSVSIGAQSPDIAQGVDTAYERRVEGEGDELDRQGAGDQGLMFGFACDETPELMPLPVHLAHRLSRRLSEVRRNATLPYLRPDGKTQVTVEYEGNRPVRLDTVVVSTQHATEIDLENLLTPDVREHVVEHVLAQLAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRW2</accession>
    <name>A0A0F4JRW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000206">
        <property type="protein sequence ID" value="KJY35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946962.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000206.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35691">
        <property type="protein sequence ID" value="KJY35691"/>
        <property type="gene ID" value="VR44_09470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5294"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="52033" checksum="0291DF19D7B58F6F" modified="2015-06-24" version="1">MDAPVIVVGAGPAGLMLAGELRLAGVAVVVLERLERRTGESRGLGFTTRTLETFDQRGILARFGDIERSTLGHFGGLPLDFGVLDGACQAAKTVPQSVTETHLEVWAADLGADIRRGHEVLSVHDDGEGVDVEVRGPGGTHTLRASWLVGCDGGRSTVRKAAGFDFPGTPATMEMFLADIRGIELKPRMIGETLPGGMVMVGPLPGGTTRIVVCERGRPPRRRESAPSFDEVAAAWQRLTGDDISAAEPVWVSAFGDAARQVTEYRRGRVLLAGDAAHIHLPAGGQGMNTGIQDAFNLGWKLASVVHGRAPLSLLDTYHTERHAVGRRLLMNTRAQGLLFLSGAEVQPLRDSLKELMAYEDVARHLAAMVTGLEITYEVGKGSHPLLGRRMPHLELAGADGPTSSTELLRPGRGVLLDLADNPRLRGRAAPWAERVDTVTARPRGTAEGLHDTTALLIRPDGYVAWAAPGSHHDLPMALDRWFGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS60</accession>
    <name>A0A0F4JS60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946639.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36593">
        <property type="protein sequence ID" value="KJY36593"/>
        <property type="gene ID" value="VR44_07615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4135"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471192" evidence="3">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10038" checksum="1711DD2031D04D70" modified="2015-06-24" version="1">MLTALGATTLLAALWFVPSANATAPDTQTSSAAPAAANTGTVTGEGTGDGTIAPEEHPATITVLSLADTGSVDTTPYVLGGTLCLGLGAGFVTFSVRRSRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSM0</accession>
    <name>A0A0F4JSM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="7" type="ORF">VR44_05800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946278.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2546"/>
    <dbReference type="EnsemblBacteria" id="KJY37372">
        <property type="protein sequence ID" value="KJY37372"/>
        <property type="gene ID" value="VR44_05800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1975"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="103"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="36774" checksum="EED7122A51990E9B" modified="2015-06-24" version="1">MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHKLGVSPATVRNDMAVLEEEGYIAQPHTSAGRIPTDKGYRLFVDKLAGVKPLSTPERRAIQNFLDGAVDLDDVVGRTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARLMLVLITDTGRVEQRMVDTQTPFGENSLADLRARLNSRVVGRRFTDVPNLVQDLPESFEIDDRATVKAVLATLLETLAEEAEERLMIGGTANLTRFGHDFPLTIRPVLEALEEHVVLLKLLGEAGESGMAVRIGHENAYEGLNSTSVVSVGYGSGGEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSX2</accession>
    <name>A0A0F4JSX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946340.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37285">
        <property type="protein sequence ID" value="KJY37285"/>
        <property type="gene ID" value="VR44_06135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2563"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="35006" checksum="635A8B6DFFB66549" modified="2015-06-24" version="1">MTDKIDKGPADATPPAGPGASGTTPYEAIKAIPVRHYGRWISAVVVAVLLGWLVYAFSQGKIIWATVGDKLFDPSVLAGLGNTVIISITSMALGLVLGILFAVMRLSKNPVTSFVSWLYIWFFRGTPVYVQLLVWFSLPLIFEYINLGPIYKNETVDVMTPFMVALLGLGLNEGAYMAEIVRAGIQSVDEGQTEASHALGMTQTQTMRRVVLPQAMRVIIPPTGNEFINMLKTSSLVSAVQYTELLRASSNIGSTAGAVMEMFFVASIWYLALTSVFSVGQYYLERRYARGAQRTLPPTPFERLKANLNMFRRTEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTP5</accession>
    <name>A0A0F4JTP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000102">
        <property type="protein sequence ID" value="KJY37525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946229.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37525">
        <property type="protein sequence ID" value="KJY37525"/>
        <property type="gene ID" value="VR44_05520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1914"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470859" evidence="1">
        <location>
            <begin position="38"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="23978" checksum="4666C328A7D0D059" modified="2015-06-24" version="1">MRRPRLGTVRARRRAVQTVMALCVLALLPSAWTHATAAGRLRTTAQAPAAGVAVVFGAGLWDGRPTPYLAARLDAAVELYRAGKVKAVLVTGDNSRTEYDEPDAMRAYLTRHGVPDGRIVSDFAGFDTWDSCVRAREIFGVHRAVLVSQSFHIHRAVTLCRAAGVDSYGVGVDNKHDATWYYGGAREVFAAGKAAVDAVFEPRPTFLGPKEEGVSRALGALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVP0</accession>
    <name>A0A0F4JVP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="10" type="ORF">VR44_03925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945937.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38230">
        <property type="protein sequence ID" value="KJY38230"/>
        <property type="gene ID" value="VR44_03925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8690"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="439"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="741"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="810" mass="86171" checksum="759FB40467978338" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVW6</accession>
    <name>A0A0F4JVW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946068.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37969">
        <property type="protein sequence ID" value="KJY37969"/>
        <property type="gene ID" value="VR44_04590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.998"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16497" checksum="3F0EB11D81FB1993" modified="2015-06-24" version="1">MITVVGPQGASAQDQSRRGWDHFGFGVPWEDSYGYSQAIRAGDTVYISGQLSHDAAGNIVGVGDFEKQVRQSFANLDKVLAHYKIPRSQIVSMKIYTKDLRKNFDTAARLHKEYNGNHKTTDTILGVSDLAFPDQLVEIEAVALVKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW78</accession>
    <name>A0A0F4JW78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946037.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37983">
        <property type="protein sequence ID" value="KJY37983"/>
        <property type="gene ID" value="VR44_04495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.707"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="6">
        <location>
            <begin position="94"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="501" mass="51178" checksum="4E773DF708BE1E5D" modified="2015-06-24" version="1">MSTAEATGFCRVTVVAPDSRIDVALPEDIAVADVYPELLRLTGQTQPVGAPTGFHLVRRSGVVLDGARTLAAQQVLDGEVLSLRPFAESLPPAVFDDVSDAVASAVVRDRHRWSDEMLRGAGLAGAAVLLVLLGFVLWYADPVRHDMHGLPGIIAGSAGVLLTAAAAVRARVYRDRGSAVALGLGGLPHLLIAGSGILAAAPGQGPGRLQFLLGCGCVLVASVALTALTPHGDAPFVAATFLAATGTLATFAAITTGASATATASVCAPVAIGLVAFLPGLSARFARLPIGYAAPQSAAPDYETPDRHDTDPYGDQPGDGRTDAGDPIDADAVAAQARRGHEMLLGLVAGCAAVTVGAAAVLGFSDNTWGRLLALAAGLAVLLRARLFRYTSQVVCALAAGLAAIGLLVLGLALHPPGNLMEEFTRYHDRGGLDIRTIWLSAAIAAGAALLAGIALVIPRKGLSPFWGRLLDLTEAAVLLSLVPLALAVLDVYGRARSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWI3</accession>
    <name>A0A0F4JWI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_04155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945980.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38098">
        <property type="protein sequence ID" value="KJY38098"/>
        <property type="gene ID" value="VR44_04155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.120"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20963" checksum="957E736BCDD1E1C1" modified="2015-06-24" version="1">MSTRAATPTRREQILREAARLFAERGFHGVGVDEIGAAVGISGPGLYRHFAGKDAMLAELLVGISERLLTGGRRRVEEVAGDPGALLASLVEGHIDFALDDRALITLHDRELDRLRDEDRKLVRQLQRQYVELWVAVVRELHPEVGEAEVRVAVHAVFGLLNSTPHLGALGREATESLLRRLAHGAFGALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX79</accession>
    <name>A0A0F4JX79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_03580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945879.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5753"/>
    <dbReference type="EnsemblBacteria" id="KJY38429">
        <property type="protein sequence ID" value="KJY38429"/>
        <property type="gene ID" value="VR44_03580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8254"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="30351" checksum="1B3EB25C6D08B1DE" modified="2015-06-24" version="1">MCGRFAAGRTPEELAGIFGIERWEPEETLAPDFNVAPTKEVHVVLDRPLKDARDPRPVRQLRALKWGLVPSWAKSPEGAARMINARSETLHEKPSFRRPFAQRRCIVPADGYYEWVTAHDERQLEVEGKKKRARKQPYFVLPADGSVFAMAGIYEFWRDATLPPDHPQAWWATCSVITAEAETTPLGVAPAEGPRSLSDIHPRMPLMLTPDRWDAWLDPARTDETGLRELLAPPPGGLMRAYPVSTAVSNVRNNGPELLGELEAPEEGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXK3</accession>
    <name>A0A0F4JXK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_05090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946149.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37721">
        <property type="protein sequence ID" value="KJY37721"/>
        <property type="gene ID" value="VR44_05090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1333"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="10">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="9">
        <location>
            <begin position="250"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY37721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="615" mass="67661" checksum="C20B8CE85D2F7FE5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY02</accession>
    <name>A0A0F4JY02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_02525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945683.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39005">
        <property type="protein sequence ID" value="KJY39005"/>
        <property type="gene ID" value="VR44_02525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6809"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="432" mass="44460" checksum="4F8F9B4CBE3100A3" modified="2015-06-24" version="1">MGEFTMPSLGADMDEGTLVEWLVAEGGEVARGDVVAVVETAKSTIEVECFESGTITELLVEPGTTVPVGTPLAVIGPTASRGRAPSAAPAPVLTGPALTTPLVRHQAAEEGVDLQAVHGSGMGGRITREDVSRAAHPAPARITASPLARRLAESLGVDLASVKGTGSRGAIKADDVRAAAGAAGEGPAPAAPAERAAPAGPPPPPAGTRAAPPPGDRLAIARLMTRAKREIPHYYLSTVIDLASALEWMRTENGARQVADRLVPAALLLKAVALAAREVPELNGHWSDDRFVPATGVRLGTAVSLRGGGLVAPALADADRMPLPELMATLKDLVARARHGRLRASETADPTLTVTNLGDQGVETVFGVIYPPQVAMVGLGRVTDRPVAVDGMLAVHPTVTATLSADHRASDGADGSRFLTALDRLLQHPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYW9</accession>
    <name>A0A0F4JYW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39024">
        <property type="protein sequence ID" value="KJY39024"/>
        <property type="gene ID" value="VR44_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17054" checksum="8D90D81B9DDD728E" modified="2015-06-24" version="1">MGGIVMMGDSRPARSDGAAGTLPATSTELSVLLTAVRRGRVLTVTGRFREPRALLVRDIARRISSNFCDGAAVVSLQGGGVRDLVAALGRLPGMPFLPPCGTADAASWLAERDMLLVLDDSDRLSPEALAWLRRLLAAAPGVRILAAGRHPLAVGQGRVHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYZ3</accession>
    <name>A0A0F4JYZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945387.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39607">
        <property type="protein sequence ID" value="KJY39607"/>
        <property type="gene ID" value="VR44_00925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2897"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046112">
        <property type="entry name" value="DUF6049"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19516">
        <property type="entry name" value="DUF6049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="721" mass="76301" checksum="A8520C995DDC1DF8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Q1</accession>
    <name>A0A0F4K0Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945348.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39694">
        <property type="protein sequence ID" value="KJY39694"/>
        <property type="gene ID" value="VR44_00695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2845"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="185"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="560" mass="59164" checksum="B56F435294F5175E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1D7</accession>
    <name>A0A0F4K1D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945331.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4818"/>
    <dbReference type="EnsemblBacteria" id="KJY39743">
        <property type="protein sequence ID" value="KJY39743"/>
        <property type="gene ID" value="VR44_00615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2829"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="90"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="554" mass="58668" checksum="64AD3117EE9AE61D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1G2</accession>
    <name>A0A0F4K1G2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">VR44_00390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956442.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1046"/>
    <dbReference type="EnsemblBacteria" id="KJY39954">
        <property type="protein sequence ID" value="KJY39954"/>
        <property type="gene ID" value="VR44_00390"/>
    </dbReference>
    <dbReference type="GeneID" id="58435566"/>
    <dbReference type="GeneID" id="63982147"/>
    <dbReference type="GeneID" id="66955263"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.76"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="8425" checksum="C162942E0F126612" modified="2015-06-24" version="1">MAKKQGAIEIEGTVIESLPNAMFKVELQNGHKVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2U9</accession>
    <name>A0A0F4K2U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945496.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4190"/>
    <dbReference type="EnsemblBacteria" id="KJY39506">
        <property type="protein sequence ID" value="KJY39506"/>
        <property type="gene ID" value="VR44_01525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4738"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="32767" checksum="EE1D82A9C6741912" modified="2015-06-24" version="1">MTDAPTPAPSATPGPDTRTRPWHGIMVATALPLREDLSVDYDAYAEHVAWLIANGCDGVVPNGSLGEYQTLTDEERARVVRTAVEAAGDGARVMPGVAAYGSAEARRWADQAAEAGAGSVLLLPPNAFRADEETVRAHYAEVAGSGLPVVAYNNPYDTKVDLTPALLARLHADGSIVAVKEFSGDVRRAYEIAELAPGLDLLIGADDVLLELALAGAVGWIAGYPNALPRSCATLYRAAVAGDTATALPLYKSLHSLLRWDSKTEFVQAIKLSMDLAGRPGGATRPPRFPLTGETEAAVRAATEKALAEGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I395</accession>
    <name>A0A0F4I395_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001781">
        <property type="protein sequence ID" value="KJY16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16164">
        <property type="protein sequence ID" value="KJY16164"/>
        <property type="gene ID" value="VR44_40585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6940"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="10530" checksum="A86A99E5279D6AD4" modified="2015-06-24" version="1" fragment="single">GAVGLLSRLGAAGADPSGAAPYAGAATVPGGAGRGGSRRDAVGLPGRVARAVAVVCAWAGLFVAASGAGLPGAVVLGAELAVTLAAGAVALRAVEPAVAWAAAGCAGAGAFGVSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5H8</accession>
    <name>A0A0F4I5H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001682">
        <property type="protein sequence ID" value="KJY17227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17227">
        <property type="protein sequence ID" value="KJY17227"/>
        <property type="gene ID" value="VR44_40070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6354"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9956" checksum="3C9B08B8F588EA22" modified="2015-06-24" version="1" fragment="single">MGQALPPPGEALTRLTEQLGDPLTARLLSDRRGSRAWKIQGPRGAVAVKANSPDEATARDKAAEMAQEDEHLLRLTAAGALRPGYRVDAGPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7E9</accession>
    <name>A0A0F4I7E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001640">
        <property type="protein sequence ID" value="KJY17917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17917">
        <property type="protein sequence ID" value="KJY17917"/>
        <property type="gene ID" value="VR44_39795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="20871" checksum="C62105F2458EC97A" modified="2015-06-24" version="1" fragment="single">FPGGADTPERLWQLLADGVDAVTPFPADRGWDLGSLHHPDPEHPGTTYVSEGGFLHDAGRFDARFFGISPREALAMDPQQRLLLETAWETLERARLAPSSLRGSRTGVFIGSGYQGYGATPGALPDGVEGHLLTGTSSSVMSGRIAYALGLEGPALTVDTACSSSLVALHLATQALRQGECELALVGGAAVMAGPNAFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8F6</accession>
    <name>A0A0F4I8F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001615">
        <property type="protein sequence ID" value="KJY18237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18237">
        <property type="protein sequence ID" value="KJY18237"/>
        <property type="gene ID" value="VR44_39635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6044"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="9091" checksum="1447C13BAB026EAB" modified="2015-06-24" version="1" fragment="single">YEYVPHRLLRSRVRDIASGTEGELMAVINENVSDCLTYERWMELAYIRAASGREFTTAVENVVPAYDQPQTAAGRRNPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAE2</accession>
    <name>A0A0F4IAE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001573">
        <property type="protein sequence ID" value="KJY18937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952484.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001573.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18937">
        <property type="protein sequence ID" value="KJY18937"/>
        <property type="gene ID" value="VR44_39300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5662"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15833" checksum="19C51CBF7C6D3B02" modified="2015-06-24" version="1">MATHTAQNTRYEELARQLTGIGAVKRDLARSLPPHCPPGAAAVLTLLDRHGEMRLSRLTEYMAVDISVSSRHVAHVAQRGWIDRETDPGDGRCRILRLTDEGRAVLTELGARYTDALEKALADWSAEDIDALNTLLARLRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAX4</accession>
    <name>A0A0F4IAX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001565">
        <property type="protein sequence ID" value="KJY19142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19142">
        <property type="protein sequence ID" value="KJY19142"/>
        <property type="gene ID" value="VR44_39215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5645"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY19142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32274" checksum="EDE9B9348B4C3963" modified="2015-06-24" version="1" fragment="single">PARTAHAAAPEARRAAALRDRVEADLRSGATTPAALLPEIGALVQEHPYDEALRALQLRALAAAGRPAEALAAYERTRRDLAEGLGTDPGPQLRALHTELLRPPPPPPPAQPRGNLRPRLTSFVGREPELAALADDLARVRLVTLTGPGGSGKTRLAEHAAAAQPESGWLVELARLDHGAAVPGAVLSALGLRENSLVAREKTPADADPTTLLVEHCAHRRLLLVLDNCEHVVDAAAALAENLLTHCPGVRILATSREPLGVPGEFLRPLDPLPPGPAHRLFADRAAAARPGFRPDEDPAAVTEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBT1</accession>
    <name>A0A0F4IBT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001566">
        <property type="protein sequence ID" value="KJY19139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952468.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001566.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19139">
        <property type="protein sequence ID" value="KJY19139"/>
        <property type="gene ID" value="VR44_39220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5646"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="589" mass="63124" checksum="456A81ACCE36DF09" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFQ4</accession>
    <name>A0A0F4IFQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001510">
        <property type="protein sequence ID" value="KJY20303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952377.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001510.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20303">
        <property type="protein sequence ID" value="KJY20303"/>
        <property type="gene ID" value="VR44_38730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5430"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="16464" checksum="CCEAA14F3BD725DA" modified="2015-06-24" version="1">MNPWLLAAIIAVVVIAIVIKRMIGEPVNAKDLFAAPVILTVIGISSLIKKADLTGSDLTWVITGAVLGTALGGLRGATVQLIDKGGVLWQRYTGRTFLALIGALAVTAGFNVLAVKMGMHENARPLQLSIGVSFLGESLVVGCRGMTSGIPFAPARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGY3</accession>
    <name>A0A0F4IGY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001461">
        <property type="protein sequence ID" value="KJY21305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952301.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001461.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21305">
        <property type="protein sequence ID" value="KJY21305"/>
        <property type="gene ID" value="VR44_38320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5273"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="33931" checksum="381CB5D85B4A04B0" modified="2015-06-24" version="1">MPSTPSVPHTPPWDVHRLPPAAGKTFLVTGGNAGIGYFVAEQLAGTGATVVLGSRDPARAGAAIASIGARVPGAAVRHVTLDLADPASPRACVDALGLDRLDAVVHNAGVALDHPPRRETADGHELMFATNHLGHFALTHHLAPLLAAAPGSRVVTTGSFAAKSERLDLDDLQSRHDYRPKRAYARSKLAQMLFALELDRRLRAAGSTTLSVLVHPGVSVLVHPGGALDSLTPSRPPVHVRTAGARLSRLPLRLAVQGKDAAAWPAARAVLDPAVGGGLMLGPRVFGLRGAPRVEPLWEHLADTTTAARLWAASCGLTGVEPAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH03</accession>
    <name>A0A0F4IH03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001463">
        <property type="protein sequence ID" value="KJY21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952306.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001463.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21297">
        <property type="protein sequence ID" value="KJY21297"/>
        <property type="gene ID" value="VR44_38345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="26270" checksum="F7286FAA136C456B" modified="2015-06-24" version="1" fragment="single">MERPAWAPPGIDISVPSVSRIYDYYLGGSHNFEVDRQAARRAMEFMPGLPKIMQANRAFMRRAVRHAVAEGVTQFLDIGSGIPTFGNVHEIARAATPEARVVYVDHDPVAVAHSRAVLAGDDQTGVIAADLRKPQDILAAPEVGRLLDPDRPVALMLIAVLHFLEDADQPYAAVAELRDALAPGSMLILTHASYEGIPLSEDVAAGTVGVYRDIRNPLVMRGHEEITRFFDGFELLEPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IK34</accession>
    <name>A0A0F4IK34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001441">
        <property type="protein sequence ID" value="KJY21843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952269.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001441.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21843">
        <property type="protein sequence ID" value="KJY21843"/>
        <property type="gene ID" value="VR44_38150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5235"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="23176" checksum="F4D5EA9275A04125" modified="2015-06-24" version="1" fragment="single">TLHHRFAVAAGDEAGARWLADATDANSHAELEQLKRTAEQWSDLDGLLLSFEDSVRVQGPPELVYDFLYRAGDWPVHLPEVTRAHVAEDRTGVQLLTMDTRAADGTTDTSESVRVCFPHAGRIVYKRTSTPRLLAAHTGEWSVDPDETGVTAVASHQVLLRAEDIEPVLGPGADLAQARDHVRRALGGACTRVLHLARRHAETAVPTLSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPC4</accession>
    <name>A0A0F4IPC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001338">
        <property type="protein sequence ID" value="KJY23890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952047.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001338.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7103"/>
    <dbReference type="EnsemblBacteria" id="KJY23890">
        <property type="protein sequence ID" value="KJY23890"/>
        <property type="gene ID" value="VR44_36960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4775"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34473" checksum="833F9310EA9B83AC" modified="2015-06-24" version="1">MTATTDSARSSLEALRTEIGKAVVGQDSAVTGLVVALLCRGHVLLEGVPGVAKTLLVRALAASLELDTKRVQFTPDLMPSDVTGSLVYDARTAEFSFQDGPVFTNLLLADEINRTPPKTQSSLLEAMEERQVTVDGTPRKLPEPFLVAATMNPVEYEGTYPLPEAQLDRFLLKLNVPLPSREDEIGVLTRHAAGFDPRDLHSAGIRPVAGAQELEAAREAVTRVTVSPEITGYVVDICRATRESPSLTLGVSPRGATALLATSRAWAWLTGRDYVTPDDVKALALPTLRHRVQLRPEAEMEGVTADSVISAILTHVPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ76</accession>
    <name>A0A0F4IQ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001274">
        <property type="protein sequence ID" value="KJY24180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24180">
        <property type="protein sequence ID" value="KJY24180"/>
        <property type="gene ID" value="VR44_36120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4465"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17294" checksum="09223655D7412587" modified="2015-06-24" version="1" fragment="single">AVIALTGDGKKRSSMAAEGSFEVNCGGGSIDDLQACGDSAVDGDTLYLTTAAKGGGNNEIVAFDLGTGKAKWRQAAGDKRSLRPLKAANGQLTAYRTGALDEPGEIVSFPVAGGAPKTLLRLPSGPAAKIEGSFLFSRSSFEDGRFFLSVTNLNGDGTDEKLLMAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQE8</accession>
    <name>A0A0F4IQE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001262">
        <property type="protein sequence ID" value="KJY24250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951851.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001262.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5084"/>
    <dbReference type="EnsemblBacteria" id="KJY24250">
        <property type="protein sequence ID" value="KJY24250"/>
        <property type="gene ID" value="VR44_35915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4341"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="23029" checksum="DDDD98294817387E" modified="2015-06-24" version="1">MTPPVVHSLREQIREHIVEGIVSGRWKPGERIVERRIAVELEVSQTPVREALRELETLRLIESAPNKGVRVRNLSAADLEEIYPVRAGLEQIAAELAAPRLAADCSALEPHVAALWEADRVQDGTAQVRHTVGFHRELVRAAGNSVLLHTWESLGIEVFTALSIRWLGTVQKSYAEEHEALVAAFRSQDPDIGVLVKRHVLGCAPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR15</accession>
    <name>A0A0F4IR15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001225">
        <property type="protein sequence ID" value="KJY24460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951734.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24460">
        <property type="protein sequence ID" value="KJY24460"/>
        <property type="gene ID" value="VR44_35305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4173"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="27587" checksum="05C96FF863F65826" modified="2015-06-24" version="1">MPRMLDVSLEVRAEIGDEEADRLLTGDDAPGSYDCTSCRTPGDPETDPTSTVLFVGEETAVLAFAHAGCIPSQVVTVSEAELQGAVRSITGDSPAPEQAAAGEVPQSVPGGQAVLGITSGLILINGELHPALVVEPTAPIARPGTTGPGDDFLPLLIEQGFIPVTDTNQVPSALEGWSVLLAGGQLHAVLQPGVGGGPQASWWQAHQALSVTDGWRAAVNKTQRVLVYAAPVGSIGQQPREDLLRDALDKAASNGKLVAASMPLAGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISF6</accession>
    <name>A0A0F4ISF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_33955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001148">
        <property type="protein sequence ID" value="KJY24917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951488.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001148.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24917">
        <property type="protein sequence ID" value="KJY24917"/>
        <property type="gene ID" value="VR44_33955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="264"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="36999" checksum="F4BF68724A8FDC98" modified="2015-06-24" version="1">MRRALAVAAVAGAAVLTRRALRRRVGRSPLWPLPALETPISGHSPRRWLRTLIVSRSEPAEGVLRLVLESDELPAWTPGAHVDVRLPSGLVRQYSLCGDPADSGRYTIAVRLVEDGRGGSREAHAQLVEGAELDVRAPRNRFELLPAPSYAFVAGGIGITPVLPMLRAATEAGADWTLLYGGRSRASMPFLPELAAYGDRVTVVAQDEAGLPDLAPLAGIRPGTLVYCCGPEPLMEAVREAAPEPAAVHLERFGAAATGPARAFTVELARTGGAVEVAADESALSAVRRVLPDTPYSCEQGFCGTCRHRVLAGAVDHRDELLTDEERADSMLLCVSRAASDRLTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISH5</accession>
    <name>A0A0F4ISH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="2" type="ORF">VR44_34830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001194">
        <property type="protein sequence ID" value="KJY24609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951646.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001194.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6527"/>
    <dbReference type="EnsemblBacteria" id="KJY24609">
        <property type="protein sequence ID" value="KJY24609"/>
        <property type="gene ID" value="VR44_34830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4037"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="31507" checksum="FC333D1A4BA8E99D" modified="2015-06-24" version="1">MSHALDASGAGSDTPNLDFAGTTPYEDYVQADVLTHLQHLRSDDPGEMVFLVTTQVMELWFTVIVHEWETAARALREDDLPVAMDALKRSLRELEALNHSWRPLAQLTPAQFNAYRGALGEGSGFQSAMYRRMEFLLGEKSASMLVPHRGAPRVHAELEKALQEPSLYDETLRLLARRGLPVPQSVLDRDLSQRYEPSAAVEAVWTELYADPAGTHADLHRLGEVLTDVAELVWRWRNDHLVATRRAMGAKTGTGGSAGVTWLEKRATKNVFPELWTARSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISQ7</accession>
    <name>A0A0F4ISQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">VR44_34600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001182">
        <property type="protein sequence ID" value="KJY24689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030770466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001182.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3253"/>
    <dbReference type="EnsemblBacteria" id="KJY24689">
        <property type="protein sequence ID" value="KJY24689"/>
        <property type="gene ID" value="VR44_34600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3905"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="7092" checksum="8FCC8328109840E9" modified="2015-06-24" version="1">MPKNKTHSGTKKRFKVTGSGKVLRERAGKRHLLEHKSSRLTRRLTGNAEMAPGDAAKIKKLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT11</accession>
    <name>A0A0F4IT11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001168">
        <property type="protein sequence ID" value="KJY24794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951546.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001168.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24794">
        <property type="protein sequence ID" value="KJY24794"/>
        <property type="gene ID" value="VR44_34270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3829"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="19511" checksum="F7718131AAB4A9AA" modified="2015-06-24" version="1" fragment="single">MADDGDLEVSPAAVAAIQKGLRAAVSELREVGDAAGASQGAGFHDLSMTAMEAGHGGLAKDFEDFCELWEWGVRSLIQDASALAGNLGIAAGTVWEEDHYIEGGFKVAANAFYGNPHASEDEIEKKSWGEIFSADVYQPDYSVQSYEKAAKDIGQTWSETKDTVTSTGKIGSMKDLLEQAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVM5</accession>
    <name>A0A0F4IVM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000985">
        <property type="protein sequence ID" value="KJY26085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26085">
        <property type="protein sequence ID" value="KJY26085"/>
        <property type="gene ID" value="VR44_30910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2687"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17701" checksum="5415CC46552E9A28" modified="2015-06-24" version="1" fragment="single">AGHIWVGHFDENPAGIRRWSPTGHIYWASDGASIPGLFDCYALNVWGTTAWACTYTDFPLVEIHPDRPDRPVRVWPNQVRGAKALAIHGERVAFYGGYGEEVDRLTRGELTEASVEPTDVGLLTLPDGHLPGRRRAVGRGSRIYVQAEPFTAWGVFDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWJ3</accession>
    <name>A0A0F4IWJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_30145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000944">
        <property type="protein sequence ID" value="KJY26397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950788.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000944.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26397">
        <property type="protein sequence ID" value="KJY26397"/>
        <property type="gene ID" value="VR44_30145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2433"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="203"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="787" mass="82333" checksum="846989495FA07C6F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXW9</accession>
    <name>A0A0F4IXW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26862">
        <property type="protein sequence ID" value="KJY26862"/>
        <property type="gene ID" value="VR44_29030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="7893" checksum="687B300160C107CA" modified="2015-06-24" version="1" fragment="single">DVYKRQLLATVAVEAEATHIPTEITVSVAGLEAGATVHASDLVLPAGTSLAVDGETAVLQVVAPQAEEPAAEAAEGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXX5</accession>
    <name>A0A0F4IXX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ORF">VR44_29040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950588.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000895.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene543"/>
    <dbReference type="EnsemblBacteria" id="KJY26867">
        <property type="protein sequence ID" value="KJY26867"/>
        <property type="gene ID" value="VR44_29040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2140"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY26867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="897" mass="99651" checksum="068108F91A028BD0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZI0</accession>
    <name>A0A0F4IZI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000875">
        <property type="protein sequence ID" value="KJY27054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950488.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000875.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27054">
        <property type="protein sequence ID" value="KJY27054"/>
        <property type="gene ID" value="VR44_28500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2027"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="434" mass="45744" checksum="9C5F8C3CDE1C24C3" modified="2015-06-24" version="1">MTEIETGAGSAVRASAPPRRPLRQLLAASVGNAVEWYDWYAYTFLATHIARQVFPSGSGDSLVPLLSTFAVFAVGFFMRPVGGLLMGAIADRRGRRTALTVTILLMGGSSLLVGLTPAYASVGVLSPVVLVAARLLQGLSVGGEFAASTTFLVESAGPGRRGLFSSFQYVSTTIGQLAASGLAALLVARLSEEAMNGWGWRVPFLLGAVLGLAGFWIRRGAEETLAHRPAEAPRPGLFDALRHHPRASLLIAGITAGGTLAYYTWTSYLPTYAELETGIAKRDALLAGTLSLAFFALLQPVGGLLSDRFGRKPCLLFFGLGFALLVVPLLRALDGSFGSLLLVQGAGMVLLTGFTSVSAAVNAEVFPARVRAAGIGLPYSLTVALFGGTAPYIGTLLKELGRPGLFPWYVAVLCLCSSAVYLRLPERAHEPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J012</accession>
    <name>A0A0F4J012_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950419.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3084"/>
    <dbReference type="EnsemblBacteria" id="KJY27239">
        <property type="protein sequence ID" value="KJY27239"/>
        <property type="gene ID" value="VR44_28120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1867"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15750" checksum="68258668EF8B828F" modified="2015-06-24" version="1">MLTRIDHIGIACFDLDKTVEFYRATYGFEVFHTEVNEEQGVREAMLKINETSDGGASYLQLLEPTREDSTVAKWLAKNGEGVHHIAFGTADVDGDAEAIRGKGVRVLYDQPRTGSMGSRITFLHPKDCHGVLTELVTSNPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0A2</accession>
    <name>A0A0F4J0A2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="16" type="ORF">VR44_27055</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 15">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="JZWV01000807">
        <property type="protein sequence ID" value="KJY27692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950227.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000807.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5219"/>
    <dbReference type="EnsemblBacteria" id="KJY27692">
        <property type="protein sequence ID" value="KJY27692"/>
        <property type="gene ID" value="VR44_27055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1573"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 14" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY27692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="46348" checksum="B5BAFD225F6B5C55" modified="2015-06-24" version="1">MISRIDLRGDALPEGGALRDLLPRAEFDVEAALEKVRPICEDVHHRGTAALIEYAQKFDGVELAQVRVPAEALTAALEQLDPAVRAALEESIRRARIVHRNQRRAEHTTQVVPGGTVTEKWVPVERVGLYAPGGRSVYPSSVVMNVVPAQEAGVESIALASPPQKEFGGLPHPTILAACALLGVDEVYAAGGAVAVAMFAYGTEDCPPVNMVTGPGNIWVAAAKRYFTGRIGIDTEAGPTEIAVLADSTADPVHVAADLISQAEHDPLAAAVLVTDSAELADAVEKELEPQVAATKHVEDRIKPALAGKQSAIVLVDDLEAGLKVVDAYGAEHLEIQTADAASWAARVRNAGAIFVGPWAPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTRDALAEVTHHVVTLAEAEDLPAHGAALKARFGWKVPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1C3</accession>
    <name>A0A0F4J1C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000765">
        <property type="protein sequence ID" value="KJY28085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28085">
        <property type="protein sequence ID" value="KJY28085"/>
        <property type="gene ID" value="VR44_26085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1372"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16083" checksum="4E460B97963529F9" modified="2015-06-24" version="1" fragment="single">DDGSGFWIAREGVRRALRAVDGRGPATLLVDRLAEAFGTPVPDPPSLRYALVDGALDQAAPVRLARHCPLVVRAAADGDAVAAAILDEAADLLAGSTAALRPRLGEPLVTVGGLLGPRGPLLHRFTARVAGWGLVPHPVGDGLAGAVALARAACAPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1J5</accession>
    <name>A0A0F4J1J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000758">
        <property type="protein sequence ID" value="KJY28147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28147">
        <property type="protein sequence ID" value="KJY28147"/>
        <property type="gene ID" value="VR44_25995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1302"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19415" checksum="DF28EC3C91AF9977" modified="2015-06-24" version="1">MEVGQAIRDCRTARRVSMAVLATRSGLSQPFLSQLERGLATPSLSSIYRIAEALDVAPGTFLRPPERPGVISHQSDPQVIQVSEAAGQVARVLIPGGRSGLMEAYEHHFEPGRGERGWFEHPGEDFVYVLEGEIVLEVRGEDPLTLRAGQSAHHRGDVPHRCVLAAGAAPARTLLVIASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J239</accession>
    <name>A0A0F4J239_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_25465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene241"/>
    <dbReference type="EnsemblBacteria" id="KJY28377">
        <property type="protein sequence ID" value="KJY28377"/>
        <property type="gene ID" value="VR44_25465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1190"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="124"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36138" checksum="0E7A12DDDB5E6E23" modified="2015-06-24" version="1" fragment="single">AGLPRGGLPRWAPAGIAVASAVLGSVIGLVFGLHSKVQWGLIAALLFVVITYTASAVVENRRQAKDRIATSLVWVCFVLAVVPLLSLMWTTISRGLKALNADFLTHSMNGVTSFEQGGGVYHALLGTLEQVALATLIAAPIGLLTAVYLVEYGKGKLARAVTFFVDVMTGIPSIVAGLFILTTWNLMLGFGPSGFAGAMALSILMMPVVVRSTEEMLKLVPNELREAALALGVPKWRVILKVVLPTAIGGISTGVMLAVARIAGETAPIMLLVFGSQLINGNPFEGAQSSLPLYIWEQYKVGSEASYDRAWAAALVLIAFVMILNLVARGIARWKAPKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J325</accession>
    <name>A0A0F4J325_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000847">
        <property type="protein sequence ID" value="KJY27336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27336">
        <property type="protein sequence ID" value="KJY27336"/>
        <property type="gene ID" value="VR44_27865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1812"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12874" checksum="F95DE1AFA53613C7" modified="2015-06-24" version="1">MGGMSGELPAYAERVLEVAERIPPGRVMTYGDVAEWLGEGGPRQVGRVMALYGGAVPWWRVVRADGVPLPGHERRALEHYRTEGTPLRETPSGEPRLAMRRARWDGGGEDAGGDEAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3J9</accession>
    <name>A0A0F4J3J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000697">
        <property type="protein sequence ID" value="KJY28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949716.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000697.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28855">
        <property type="protein sequence ID" value="KJY28855"/>
        <property type="gene ID" value="VR44_24320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.846"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="33061" checksum="EA223E820BC04972" modified="2015-06-24" version="1">MLIHQLALVSETKSNTITPSQITRVAAALQKQATRDFAPLWQVNATVDAFDRLEDVPVGYWPLIVVDDVPGAAGYHTDENKQPYSLIEYSDSWSLTASHEMLEMLADPFGNRLVSGKSPHPDQGQARFLVEVADPSEDEAFGYTINGLLVSDFFTPRFYDPVTVPGTRYSFGGHIQAPRTILRGGYISFEDSATGDWWQQIWFEGNEPKFRKLGKLSGSGSIREAIDAQTKTVSRLAASGPSSKQYLAARTLTAHVKESTSARAGVWRAEIERLKGANPAEKAFKDKAAKPAKAKTKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3L2</accession>
    <name>A0A0F4J3L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949704.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28875">
        <property type="protein sequence ID" value="KJY28875"/>
        <property type="gene ID" value="VR44_24255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.831"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="30085" checksum="D2CDE7A631530FB8" modified="2015-06-24" version="1" fragment="single">MSGDRVKGDRLAPDARRLCEAMAAGFPGPGDVAALRAVVAAGSERPGVRGPEVASVRDSVASGVPVRVYDPAPGERGRVLVVYLHGGGWVMGGLDTHDALCRELAAASGAVVVSAGYRLAPEHPWPAAADDALAVLLWARAGADGLGCDAGRVVVAGDSSGGNLAAVTALRAPQLVAGQLLVYPPLDASMGSESVAAYGRGYFHTAAHMAWYWDQYGGDPAHPHVSPLRAPDLSGLPRTLIVLADCDLLRDEGLEYARRLGEAGVDCEVRLHPGAFHGFLGLPLPAAAAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3M3</accession>
    <name>A0A0F4J3M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28885">
        <property type="protein sequence ID" value="KJY28885"/>
        <property type="gene ID" value="VR44_24310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.843"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22302" checksum="90526E8150460AD8" modified="2015-06-24" version="1" fragment="single">AQPQLTADWVRRQLAAGWHLMPIWVGPQPWHSTSTGLSTDPSEADDQGREAAEGAAAAARALGLPAGTPLYADLENYTDRDTWDAPVVAHLTAWTVRLHELGYHAAAYVSASSGAKALSAHYAQAPQAMPDVLWVARWNGAASVTDADLGLPSGTTQWSGPRRAHQYQGDHDATYGDETINIDRNWVDVAPTALTPLPTVTPPGRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3W2</accession>
    <name>A0A0F4J3W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000814">
        <property type="protein sequence ID" value="KJY27616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27616">
        <property type="protein sequence ID" value="KJY27616"/>
        <property type="gene ID" value="VR44_27210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1631"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6657" checksum="479B50A1BF4AD259" modified="2015-06-24" version="1">MDAADEVRERIVAARLALDDLEASLDLARSARPAAPGPREEPDGPDPADGPDPAPRRQLESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Y8</accession>
    <name>A0A0F4J3Y8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase</fullName>
            <ecNumber evidence="5">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_23855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000680">
        <property type="protein sequence ID" value="KJY29067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949628.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000680.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29067">
        <property type="protein sequence ID" value="KJY29067"/>
        <property type="gene ID" value="VR44_23855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.744"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="7">
        <location>
            <begin position="240"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="463" mass="49629" checksum="33805CDE968CD2C5" modified="2015-06-24" version="1" fragment="single">RLPQGRPGVGWRTLAQDTGPAAEPTLTVRAVDAAVAELAAVSGPGAQAERRRIVAALLGAATGEEQRFLRSLLSGEVRQGALDAVALEGVAAAAGVPAAELRRAVMLDGSLPRVAAAVLADGAAALSGVALRIGQPVQPMLAGTARSLEDALRALGPCAVEEKLDGIRVQVHREGAEVHVYTRSLDEITGRLPEVAELALGLPGERFVLDGEVIGHDPAGRPVPFQEIASRVGSRVDVEAARRTLPVTAFFFDVLALGDRVLLDLPVRERYAALAGLVPEAARVRRLAVEDPAAQAEQAREFWAESLRRGHEGVMVKGLGSPYAAGRRGKQWLKVKPVHTLDLVVLAAEWGHGRRTGLLSNLYLGARAADGGFAMLGKTFKGLTDEMLRWQTQRLSELAVEDDGFTVRVRPELVVEIAYDGLQRSPRYPAGVALRFARVLRHRPDKGPREADTVETVLEQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J477</accession>
    <name>A0A0F4J477_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000668">
        <property type="protein sequence ID" value="KJY29157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949584.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000668.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29157">
        <property type="protein sequence ID" value="KJY29157"/>
        <property type="gene ID" value="VR44_23610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.667"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="42557" checksum="F819283945E0F804" modified="2015-06-24" version="1">MSSELLTGDPGRETARRARRNQLARTAQWFAGLEADPYALVLRTGTGAPEAAEEAVRALGPLHRSALPDTWVTAHRAVAEEVVGHPAFDAPGPAATPGGGRPPPFRSAVLALDRALDRATAAALAPLTAFGGPLLWAADADSLEKRTATWARTLLAGLGERFDLAEDFARRLTGPVLAEQLGLPEAAHERFCRLLPDCRHVLDSLLCPQTHACARAAQAAETAMAGLLAEALHRPTAETVRASLVTALSAAEPTAVLICNAVRLLLDRPGGWQRLAEDPDRAAGEAVAHTLRTAPPVRLESRAVRSAVTLAGTPLPVGARVTLLVAAVNRDPPAEPDARPFGLCADLHFGLSAHLVEALARAALRTLARILPDLRADGDPVTRLRSPVLRAPERRPVAGNPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4P3</accession>
    <name>A0A0F4J4P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000653">
        <property type="protein sequence ID" value="KJY29332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949510.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000653.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29332">
        <property type="protein sequence ID" value="KJY29332"/>
        <property type="gene ID" value="VR44_23225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.585"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470147" evidence="1">
        <location>
            <begin position="27"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="28821" checksum="D646CA1718F0324B" modified="2015-06-24" version="1">MNKPLAGAVLSLLLTGAAATPAVAQASTPQQAAAVTYAGTVALSNCSGSVVRTPASQPDDPALVLSNGHCLETGFPAAGEVLVNQASSRSFSLLNASGSKVATLRASKIAYGTMTDTDVSLYQLTKTYAQIQSQYGIAALTLNDTHPVQGSSIKVVSGYWKRTYSCSVDGFVYRLKEGDWTWKDSVRYTSSCNTIGGTSGSPVIDTTTGKVVAVNNTGNEDGQRCTDNNPCEVDQAGNVTVRQGINYAQETYVLVPCIGPGNQIDLNRPGCTLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4U2</accession>
    <name>A0A0F4J4U2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="12" type="ORF">VR44_23325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene115"/>
    <dbReference type="EnsemblBacteria" id="KJY29270">
        <property type="protein sequence ID" value="KJY29270"/>
        <property type="gene ID" value="VR44_23325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.605"/>
    <dbReference type="eggNOG" id="COG1623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY29270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="40353" checksum="096E59AD333E80C7" modified="2015-06-24" version="1">MAAKDGAAASGKSGASSKHEALMRASLTAVAPGQPLRDGLERIVRGNTGGLIVLGMDKTVEAMCTGGFVLDVEFTATRLRELCKLDGALILDKDLTKILRAGVQLVPDASIPTEETGTRHRTADRVSKQCGFPVVSVSQSMRLIALYVDGERRVLEESGAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELTVGIEQERELVIRDYVPEPTAKRSRTVEEALPALDALTHPELLELAIVAKALGYTGSPETLDSAVSPRGYRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J654</accession>
    <name>A0A0F4J654_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000735">
        <property type="protein sequence ID" value="KJY28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949927.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000735.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28406">
        <property type="protein sequence ID" value="KJY28406"/>
        <property type="gene ID" value="VR44_25435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1183"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="42887" checksum="A8CD4298AA040A5D" modified="2015-06-24" version="1">MDVWVHPELRAAAAAEDWAALLRAWRKLTRSSQTRLGGLLGLAQSDVSAIENRRRAVTSVEVRQRIIDGLGVPVELLGVRQEGLPLPSLVLPGVVSEADGERLAGVRKGGLRLDAASVDAMDALLAAHRRAEDTVGSRAVAPLVTAQFRAVAGLHGQARGALADRVVRLLAEYAQFLAWMAQDQDNAAVALGWFDRSYDWALESGYGDMAATTMSMKAHLAWSGGEGRRCARLGEAAAATAGASAATRAMAVQMAGRGYALEGERGAAYARLDEAQRIIVDAVDAPPWLYFYGESWFAAQRGMADLHLRDWDGAVGNLTAGLAGFTPAFRRDRAWYGACLAHAYAGAGEAEAALTTALGVVRDASEIGRPHGWTELHRVGALLLRRGSREGRTLVDALAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6H5</accession>
    <name>A0A0F4J6H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949196.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29952">
        <property type="protein sequence ID" value="KJY29952"/>
        <property type="gene ID" value="VR44_21515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.181"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12366" checksum="F452F9902B4FE2BC" modified="2015-06-24" version="1">MSAIPIYLWRLAPEGLATRRQLRAAGLRPGGQPVVGELQRPRFRRGPLVAYLYRVDLAVPVRPMTPAKRRALDRANTARRTCPACHRDAGYVIPVSLGMCVPCAYPDTELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6M3</accession>
    <name>A0A0F4J6M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000599">
        <property type="protein sequence ID" value="KJY30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949172.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000599.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30007">
        <property type="protein sequence ID" value="KJY30007"/>
        <property type="gene ID" value="VR44_21390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19779" checksum="91EF68AA9F32D6B8" modified="2015-06-24" version="1" fragment="single">MTLLVPLYVHPAEDPGAWHRLITGAAATYGVVLNPADGPGERPDPAFAAAAAALRTAGARLLGYVDTLYGARGQVEVVHEMCRYQEWYAVDGCFLDRVAPTREELPGARRMIRSLRRLGARPVVLNPGVHPDSGYVRLGDLTVTFEGHWSTYVSSFTRPPWTARHAPERFCHLVYGVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7V3</accession>
    <name>A0A0F4J7V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000684">
        <property type="protein sequence ID" value="KJY29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949647.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000684.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29011">
        <property type="protein sequence ID" value="KJY29011"/>
        <property type="gene ID" value="VR44_23960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.768"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13913" checksum="317F165F6FC308F9" modified="2015-06-24" version="1">MSVQLNHTIVHSRDNRESAEFLAHILGLEVGPEWGPFVPVETGNGVTLDFATIPAESITPQHYAFLVSEEEFDSAFEKIRAGGVEYFADPHRKHPGEINHNDGGRGVYFLDPVGHAMEIITRPYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7W8</accession>
    <name>A0A0F4J7W8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">VR44_21740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949241.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene138"/>
    <dbReference type="EnsemblBacteria" id="KJY29894">
        <property type="protein sequence ID" value="KJY29894"/>
        <property type="gene ID" value="VR44_21740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.228"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28713" checksum="9DF9D2387B29B79D" modified="2015-06-24" version="1">MLLTIDVGNTHTVMGLFDGEEIVEHWRVSTDPRRTADEMAVLLQGLMGMHPMLGSELGDGIHGIAICATVPSVLHELREVTRRYYGDVPAVLVEPGVKTGVPILMDNPKEVGADRIVNAVAAVELYGGPAIVVDMGTATTFDAISARGEYVGGVISPGIEISMEALGMRGAQLRKIELARPRNVIGKSTVEAMQSGVVYGFAGQVDGIVHRMARDLVGPDGDPDDVRVIATGGLAPIVLGETTVVDEHEPWLTLIGLRLVYERNAPNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J800</accession>
    <name>A0A0F4J800_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_21735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949240.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29893">
        <property type="protein sequence ID" value="KJY29893"/>
        <property type="gene ID" value="VR44_21735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.227"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="154"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY29893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="33970" checksum="AB67FE6029C56120" modified="2015-06-24" version="1">MSSTPELPLIEQNEGGCGDDCGCGEGEESGLDPALAQLLADAGLDPIEVEDIAHMALSEDLDGGVDVTTAATVPEEAEAVADFVAREAGVVAGLRIAEAVFSVVCTEAFEVERHAEDGDKVEAGQLLLSVRARTRDLLTAERSALNIVCRLSGIATATRRWADVLEGTKAKVRDTRKTTPGLRSLEKYAVRCGGGVNHRMSLSDAALVKDNHVIAAGGVAQAFKAVREAFPDVPVEVEVDTMHQVREVVDAGADLILLDNFTVPETEEAVTIVAGRAVLESSGRLTLESARAYAETGVDYLAVGALTHSSPILDIGLDLREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J848</accession>
    <name>A0A0F4J848_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948943.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000555.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30562">
        <property type="protein sequence ID" value="KJY30562"/>
        <property type="gene ID" value="VR44_20155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8736"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="1">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="24202" checksum="BF4790D0714DC676" modified="2015-06-24" version="1">MSLVVFESQKPIHCAECRRGPLRHLVRESGVPRCLDCADLGHLVYLPRGNAALTRRAREASSLSAVVVRRHRGRRRYERQGLLVEDAALARAERACLADADARARRRERDRLRRAAEDVRFTAAFAAEILRLFPGCPPERARAIASHASVRGSGRVGRTAAGRALDEQAVSMAVRAAVRHTDTEYDALLMAGVHRFEARARLAARIDAILDGWRAGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Y6</accession>
    <name>A0A0F4J8Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_21030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949104.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30208">
        <property type="protein sequence ID" value="KJY30208"/>
        <property type="gene ID" value="VR44_21030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8938"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108280" checksum="21A48F880493CB0E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9J5</accession>
    <name>A0A0F4J9J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30875">
        <property type="protein sequence ID" value="KJY30875"/>
        <property type="gene ID" value="VR44_19310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8469"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="36770" checksum="7C2CC303A16894BF" modified="2015-06-24" version="1" fragment="single">MAHVLVIGGGVAGLATALLAVRRGHTAEVFERDTRAPGAALDRDFFDWHRPGVPQAAQPHLLLGAARAVLRAELPDVYAEMLRLGARERHELDWFDVRPPARSGDEDLVLVQARRIVLESALTTALRAEPDAVLRYGEPVTALTTAGGPRPRVTGLGTPRGGYAGDLVVDAAGRRGGSAALLAAAGCRPGTVERHRTGLAYFCRWYRLPDGVDEGPRRPWTVTGGAFAGCAVFPSDNRLFAVTVFAHTGDPTRGALRDPAVFEAAARTFPPGAAWLGLGAEPLSAVLAIAGLDNRWSPLADGRGPVVSGMVPVGDALTHTNPTLGQGTSLALWAADRVARTAHRDPGSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA54</accession>
    <name>A0A0F4JA54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">VR44_19850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948889.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3108"/>
    <dbReference type="EnsemblBacteria" id="KJY30684">
        <property type="protein sequence ID" value="KJY30684"/>
        <property type="gene ID" value="VR44_19850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8589"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="32903" checksum="027AF4316B333602" modified="2015-06-24" version="1">MGAQLRVYKRRIRAITATKKITKAMEMIAASRIVKAQRKVAASMPYATELTRAVTAVATGSNTKHALTTEVEAPTRAAVLLITSDRGLAGGYSSNAIKQADRLTERLRAEGKEVDSYIVGRKGVAYYGFRERKVTDSWTGFTDSPAYADAKRVAAPLIEAIQTETADGGVDELHIVFTEFVSMMTQNAVDGRMLPLSLDQAQEEDGAKGEILPLFEFEPSAEDVLDALLPRYVESRIYNALLQSAASEHAARRRAMKSATDNAGELIKSLSRLANAARQAEITQEISEIVGGASAMADATAGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAL7</accession>
    <name>A0A0F4JAL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949180.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29996">
        <property type="protein sequence ID" value="KJY29996"/>
        <property type="gene ID" value="VR44_21435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.163"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20953" checksum="E57762EEE9303380" modified="2015-06-24" version="1">MLLSQTSGDGAGRAALIVIDMLNTYEHEDADVLVRSVREALPGIGALLGRARDAGAPVVYVNDNFGLWRSHHGEILEAALAGRYRDLVEPVAPDEESLFVVKARHSVFYETPLAYLLGQLGVRRVVLCGQVTEQCVLYSALDAHIRHLDVVVALDAVAHIDAGLAEAALRMMERNMAAELLRSGEITFDGVPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBG5</accession>
    <name>A0A0F4JBG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000514">
        <property type="protein sequence ID" value="KJY31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948693.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000514.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31144">
        <property type="protein sequence ID" value="KJY31144"/>
        <property type="gene ID" value="VR44_18780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8367"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25728" checksum="7DDEA983F8C30A70" modified="2015-06-24" version="1">MTSLDRPSTPGSAPSGPPGDQKEVTQAALFDAFGGIRGTVETMLPGLLFVMIYTINKDVTMSAIAAGVVAVLLVIVRLLRKDTVKHAFSGVFGVAVGVAFALFTGSAKGFYLPGMIYGVGLGVAFTLSALVGFPLLGVILGPVFKENLSWRTRNPGRKKAYTKASLAWGLIFLAKYAILFPLYWWGDETQLGWVLIALKLPPMVLAVYFTWVFLAKAPPPIDVIAEYEAEEQAAREKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBG8</accession>
    <name>A0A0F4JBG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949051.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000572.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30331">
        <property type="protein sequence ID" value="KJY30331"/>
        <property type="gene ID" value="VR44_20745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8867"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="31821" checksum="29D6B9D6B769F391" modified="2015-06-24" version="1">MTVRKNQATLTAEEKRAFTNALLELKRTGRYDHFVTTHNGFIMSDTDSGDRVGHRSPSFLPWHRRFLLDFEAALQSVDKSVSLPYWDWTADRTARSSLWAADFLGGTGRARDGQVMDGPFAYATGKWEITVRVDGRPYLRRALGEGVAQLPTRAEVDAVLAMPVYDMAPWNSSSGGFRNNLEGWRGANLHNRVHVWVGGQMGTGVSPNDPVFWMHHAFVDKLWSDWQAKHPNSPYLPAAGTPNVVDLRDTMRPWNDVTPADMLDHRTFYSFDTEPASAARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBJ5</accession>
    <name>A0A0F4JBJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000512">
        <property type="protein sequence ID" value="KJY31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948683.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000512.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31174">
        <property type="protein sequence ID" value="KJY31174"/>
        <property type="gene ID" value="VR44_18730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8357"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7702" checksum="0C389FFDA19A8E25" modified="2015-06-24" version="1">MDTSRGHTERGAPLFRVVRGEPGPEELAALTAVLLARTAGPAAEPAPATSAPGRRGPRRRGRYTAPGAWRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBR4</accession>
    <name>A0A0F4JBR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948430.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31802">
        <property type="protein sequence ID" value="KJY31802"/>
        <property type="gene ID" value="VR44_17415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8020"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9371" checksum="16281E5513306CCC" modified="2015-06-24" version="1">MTSTGDRDPSEPRPARAGREPRKQVLLRLDPQVYDALARWAGEELRSANAQIEFLLRRALSEAGRLPGGAAPIPPRGRPRTGRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBZ8</accession>
    <name>A0A0F4JBZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000500">
        <property type="protein sequence ID" value="KJY31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008738568.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31334">
        <property type="protein sequence ID" value="KJY31334"/>
        <property type="gene ID" value="VR44_18410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8232"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7699" checksum="5B00EFA681A60C26" modified="2015-06-24" version="1">MAAGERPLSEVQFLTVAEVASVMRVSKMTVYRLVHNGHLPAIRVGRSFRVPENAVHEYLRESYVGVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC81</accession>
    <name>A0A0F4JC81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ionic transporter y4hA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_20095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948934.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30581">
        <property type="protein sequence ID" value="KJY30581"/>
        <property type="gene ID" value="VR44_20095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8643"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="223"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="367" mass="37272" checksum="8FD8F7D7262B1F73" modified="2015-06-24" version="1">MSTATRRSPLTDWTVLVPVAALAALVLSWGRDLPGALVGLVALCLAGAVLAAVHHAEVVAHRVGEPFGSLVLAVAVTVIEVALIVTLMADGGDKTASLARDTVFAAVMITCNGIVGLSLLVGALRNRVAVFNAEGSGAALATVATLATLSLVLPTFTTSKPGPEFSSAQLTFAAVASLALYGLFIAVQTVRHRDYFLPVATENTPDGEEEHAQPPTARAALTSLGLLLVALVAVVGNAKAVSPTIEKGVADAGLPHAVVGVIIALLVLLPETLAAVRAARRDRVQTSLNLGYGSAIASIGLTIPAIALASIWLSGPLLLGLGPTHMVLLTLTVVVGALTLVPGRATLLQGGVHLVLLAAYLFLAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCJ2</accession>
    <name>A0A0F4JCJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ORF">VR44_19750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948871.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000545.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3127"/>
    <dbReference type="EnsemblBacteria" id="KJY30706">
        <property type="protein sequence ID" value="KJY30706"/>
        <property type="gene ID" value="VR44_19750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8569"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="463" mass="49525" checksum="ABA680A17B359C05" modified="2015-06-24" version="1">MSRSAHPAGPRHADVLPEGHYAPPPADLNALDEKVWSRTVTRNADGVVTVGGIEVTRLAEEFGTPGYFLDEEDFRARCRAWAHAFGKDADVFYAGKAFLSKAVVKWLKEEGLNLDVCSGGELATALAAEMPAERIAFHGNNKSESEIRRAVSAGVGRIVLDSFQEIARVAHIAGELGVRQPVQIRVTVGVEAHTHEFIATAHEDQKFGIAVADGSAAEAVRRALGHESLELLGVHSHIGSQIFDMAGFEVSAKRVVQLLAAVRDEHGVELPEIDLGGGLGIAYTSADDPREPHEIAKSLTEIVARECEGAGLKAPRISVEPGRAIVGPTAFTLYEVGTIKPLEGLRTYVSVDGGMSDNIRTALYDAEYAVTLVSRVSDAEPMLVRVVGKHCESGDIVVRDAFLPADLAPGDLIAVPATGAYCRSMASNYNHALRPPVVAVRDGAARVIVRRETEEDLLSLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD03</accession>
    <name>A0A0F4JD03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000480">
        <property type="protein sequence ID" value="KJY31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948500.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000480.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31613">
        <property type="protein sequence ID" value="KJY31613"/>
        <property type="gene ID" value="VR44_17790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8100"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="MASE1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="33863" checksum="C96AD05E909731F3" modified="2015-06-24" version="1">MVRTLQWRRTCGTLLLVLAVAAAYYATGRLGLLRQVSVGGAVVTPLWPPTGIALAALLKFGPRVWPAFAIGTYLAIEQLAAFQPADLGIVAGNVLAPLCAFLLLRAAGFRPELDRLRDGLALVFLGGLLPMLISATAGSWTLVLTGNLSSGGFWPTWAAWWAGDTMGVLLVTPVLLALHWAPLPRDPLRVAEAAALTVATIVATVAVTHSTMSLLFVVFPLLIWAAVRFQLAGAAPCALLVSVLAIWAATDHAGPFTGQSLLETMVNLQALNGAAALTGLLLAALVAEQNNVRLKIEEACEELAEVVAHLSPGRGDEDPAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDG2</accession>
    <name>A0A0F4JDG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948176.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32397">
        <property type="protein sequence ID" value="KJY32397"/>
        <property type="gene ID" value="VR44_16055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7632"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470407" evidence="1">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="46624" checksum="AAD91A659265FA9C" modified="2015-06-24" version="1">MDPGTTRSRRTAATALALALPLAALAACGAGGGTDTSAEQGSGTGTITVWAHQGQANEAAALQTAVKTFNSSQQKVTAKLTLIPDTDYTKTITATDASKLPDVMEFDGPTMANFVYNKKLAAIDSYVSAKTLANATDAIKAEGEINGKQYGLGMYDSGLGIYGNKKLLDAAGVKYPTGLSDAWTAAEFTDAVKKLAAQDSDGKSLDLQESGGYANEWGTYGFAPIAWSAGGSLLKDDKAEGALDTPSVASALKTFQSWKTYTDPNTDGNAFANGRVALSWVGHWMYPAYSKALDKDLVVLPLPDFGNGPKTGQGSWEWGIGAHTKNGRAAGAFLDSLLDDTNVTAMTTANGAPPGTRSALAQSSLYRQGGPLQLFADQLAKPCGDSRIDKSCVAVTRRITPGYPTVTAEFSQALSDVYGGADPNSALAKAARAIDQDFSDNDGYKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDM1</accession>
    <name>A0A0F4JDM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine--scyllo-inositol transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000461">
        <property type="protein sequence ID" value="KJY31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948405.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000461.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31853">
        <property type="protein sequence ID" value="KJY31853"/>
        <property type="gene ID" value="VR44_17270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7989"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="47384" checksum="DD5CFE0691A178B4" modified="2015-06-24" version="1">MLAVDGGSPLLAGHEPAPWPHITDTDRKAVLDALDQATPWHWPMRTVRELEDAWAEFTGMPYVLAANSGTAALHMAIAAAGVEPGDEVLVPADTFLASASCVLQANAIPVFVDTDPATFNIDPARIEERITDRTRAVVAVDLNGLPADHDALRAVTERHGLVLIEDASQAHGASYRGRPVGSLGAMSGASLNGSKTLSALGEGGLFATRDEEQHRLARRVLMFGEELPGQSRDYNARIMGWNYRIDVLAAAFARSQLTRLPEMSLVRQANGAALTRALAGVPGIRTPAVPEDRTHVYFFYLLLVMPEELGLDGLPVAAFRDALARAVNAEGLQIMRWQPQPVPGQTLFRELRGYGRGCPWSCGHARAGHHYDPEEYPVSEEICLRRLVLGQSFSSFGPPNDVTTMRRYADVLYKVLVEEREALVALTRRTAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEP5</accession>
    <name>A0A0F4JEP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000391">
        <property type="protein sequence ID" value="KJY32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32827">
        <property type="protein sequence ID" value="KJY32827"/>
        <property type="gene ID" value="VR44_15195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9016" checksum="0C530BCFC7290EB4" modified="2015-06-24" version="1" fragment="single">MAAADHCPDVQLSQTRHRAALVDGWNIEPGSTVLELGCGQGDMTAVLAEAVGPRGRVVAVDVAEPSYGAPVTLGESAARLAAGPLGPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF87</accession>
    <name>A0A0F4JF87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948007.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000387.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32875">
        <property type="protein sequence ID" value="KJY32875"/>
        <property type="gene ID" value="VR44_15100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7439"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="40386" checksum="8B90BEA00FDF07DA" modified="2015-06-24" version="1">MAELAAVSVRTLHHYDEIGLVRPSARTSGGYRAYSAADVERLREVLAFRRLGFGLREIADLVDDPATDPIARLHRLRGLLVEQRDRTAVMVTAIDKELEERAMGVRTTTPEDQLKVFGAQLYEAIGSAYPATRRTEPRIAERIWDALGDARTVLNVGAGTGSYEPPDREVTAVEPSAVMRAQRPVGAAPCVAASAERLPFADQSFDAAMAVSTVHHWPDPVAGLREMRRVARRVVVFTYDASTTGWLQRFWLTRDYLPEFAGLLADWPSLADMTRAIGGSAEPVLVPWDCADGFFEAHWRRPEAYLDERVRRAVSVWTRVGPRAEQRAVNMLRADLASGRWTERNRDLVALDAAELGLRLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFP2</accession>
    <name>A0A0F4JFP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_14715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000377">
        <property type="protein sequence ID" value="KJY33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33010">
        <property type="protein sequence ID" value="KJY33010"/>
        <property type="gene ID" value="VR44_14715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7270"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="144"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="273"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="39457" checksum="BC087E89F2057C9B" modified="2015-06-24" version="1">MSRKVHLANKTSVEKVTCGPSQLDKLLTVARRSMGWLREGSSVPQQQVIRDFAKSRSKALADIKAKLPVRQRAGMPRVKRKREARPSLNYTRRGFRLKDGRLHLAGGILLSVVWSRELPSAPSSVRVYQDSLGHWYASFVVTAPSEPLPSTGRAIGIDWGVRETATTTSDAHDLPHARHGKKSEQRLARYQRMMARRATPKGRPATRGYEKARRAAAKVCKKIARQRQDTARKWAKSVVRDFDTLAVEDFRPKFLAKSSMARTAADAAIAATKTALVEMARKHGRMIHLVKPAHTTMECARCGARAKHALPLSGRTYTCATCGAISPRDKNSARVMLVRAGLNPASADLVRPAACQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFY5</accession>
    <name>A0A0F4JFY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000374">
        <property type="protein sequence ID" value="KJY33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947897.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000374.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33110">
        <property type="protein sequence ID" value="KJY33110"/>
        <property type="gene ID" value="VR44_14515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7163"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="29758" checksum="7D8694FC68DD6DFA" modified="2015-06-24" version="1">MTTTLRPSGPLQQSEGGARSRPYEVRVNSRRVGTLLIAADTPFGPTVGEIRDLAIDEPDRRRGRATVAALAAEEVLRGWGCRRVRISVPAGSPGGLRLAAALGYAETSRNMAKELPERPPALSEGARGRPMTEAEYAVWNVRAREEYAASWTARGMRPEAARAKSEADHDARLPEGLDTPGVTFAVLESAGTPVGHVWLAAAGEGGEGAYVYDVAVAEEHRGRGHGRDLMLLAERTAIAQGHRVLALHVFAANTPALRLYESLGYRTTDVNYAKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGZ0</accession>
    <name>A0A0F4JGZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000425">
        <property type="protein sequence ID" value="KJY32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948221.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32246">
        <property type="protein sequence ID" value="KJY32246"/>
        <property type="gene ID" value="VR44_16285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="45418" checksum="5463EB7AC9A5DB2A" modified="2015-06-24" version="1">MIYTILAWVCAFVGLAAFAYRLPDLLRRRHDVALWALCTYFLCSGISFLVDLDLLRLHISAFFGLPNITSLITQAAVVVLTAAQQVVLVYWSSPPAEARRMARRRVLGFGGALAVLVVSSFYVGPVAHSETATSTILLSIQHGGYAVYMSFYLLICAVGQFETVRLSLRFTTMANRQWLKVGMRTVTVGASLILVYCVTRGVQIAGTRLDYDGSPLDPIQWTAGSVGALLQIAGWTIPSWGIRITRARGWIRSYRSWRRLRPLWWALYQASPDIALDPPRSWLRDLVPPRDPHYRLYRRVIEIRDGQLILRTSLSLEDFSRVARSLDLPEDPTSPLGEALQVRAVLSRPAEERSERAERADASEIPARPPYEDFRDEVEWLSQVASSFNRLGQGRPGPVDVGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHD8</accession>
    <name>A0A0F4JHD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_14360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947867.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33168">
        <property type="protein sequence ID" value="KJY33168"/>
        <property type="gene ID" value="VR44_14360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470479" evidence="9">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15376" checksum="5456D46AEE641380" modified="2015-06-24" version="1">MNLVTLLPFIVLIGAMFLMTRSAKKKQQQAAQMRDHMTAGTGVRTIGGMYATVKEIGDDTVTLEVAPGVHAIYAKNAIGAVLEDDEYNRIVHGIATPEDTPVVPDDASSLTEDEAPKLDLGKKDEPKGDDEPKDGKTDGEPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI59</accession>
    <name>A0A0F4JI59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_12990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000329">
        <property type="protein sequence ID" value="KJY33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947619.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2313"/>
    <dbReference type="EnsemblBacteria" id="KJY33905">
        <property type="protein sequence ID" value="KJY33905"/>
        <property type="gene ID" value="VR44_12990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6715"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="42018" checksum="DAC65435C38CCC86" modified="2015-06-24" version="1">MQRRIYDADHEAFRETVRTFLTKEVLPHYEQWEKDGIVSRDAWRAAGRQGLLGLAVPEEYGGGGNPDFRYAAVLAEEFTRAGAPGLAIGLHNDIIGPYLTSLATEEQKRRWLPGFCSGETITAIAMTEPGAGSDLQGIRTSAEDRGDHWLLNGSKTFISNGILADLVIVVAKTTPEGGAHGLSLLVVERGTEGFERGRNLDKIGQKAQDTAELFFNDVRVPKENLLGELNGAFVHLMTNLAQERMGIAMAAIAAAEHLLEITTTYVKEREAFGRPLAKLQHIRFEIAEMATECAVTRTFLDRCITDHANGELDHVHASMAKWWATELQKRVADRCLQLHGGYGYMTEYRVARAFTDGRIQTIYGGTTEIMKEIIGRSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JII6</accession>
    <name>A0A0F4JII6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000394">
        <property type="protein sequence ID" value="KJY32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32781">
        <property type="protein sequence ID" value="KJY32781"/>
        <property type="gene ID" value="VR44_15230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="18590" checksum="44B411A8E70233C5" modified="2015-06-24" version="1" fragment="single">MDAYRTCEFVTLAKDGTPLAWPTAVARREDGTLLLTTSLAFAQKAFNVRRDGRVALLFSDPTGSGLEHAPQIFVSGRAECPDTVMTGPRGAEEYWRRLFERQPHSRAYLRLPMRPMMSWYYLRLLITVDPEQVIVRPPLEELPNHDLPATAAGTPPLPGAEQLGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIR8</accession>
    <name>A0A0F4JIR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000347">
        <property type="protein sequence ID" value="KJY33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33668">
        <property type="protein sequence ID" value="KJY33668"/>
        <property type="gene ID" value="VR44_13535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6958"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="11270" checksum="40FDCDA6CB3D589F" modified="2015-06-24" version="1" fragment="single">MSLPHAILTALLERPSSGLELTRRFDKSIGYFWSATHQQIYRELGRLEEAGLIRALPSEGPVRGQKKQYEVLPGGSAELARWVDERQDPKPMRDALLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ10</accession>
    <name>A0A0F4JJ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33799">
        <property type="protein sequence ID" value="KJY33799"/>
        <property type="gene ID" value="VR44_13270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6873"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20012" checksum="948347B7DBB3C5B4" modified="2015-06-24" version="1">MTAVCAVLFALITWQVLVRGPLLTPDQELSRALVHTLPDAVTERLADLGNVEVAVPVLVLAVAYAVRRGRRLAALAAGLAMALVPALIVPLKEWTARPGPLEPWAAGYYPSGHTATALTAYTAAALLLAPHTRRRWPLPAAAALTALTAAGLVVRGFHWPLDVLASLLMCTPLLLGVRWAAGRGARRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNB9</accession>
    <name>A0A0F4JNB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000206">
        <property type="protein sequence ID" value="KJY35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946961.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000206.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35690">
        <property type="protein sequence ID" value="KJY35690"/>
        <property type="gene ID" value="VR44_09460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5292"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="163"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="28087" checksum="F90C019745186EFE" modified="2015-06-24" version="1">MNQRTFAVLEPHTTAAGVNGGFLPAEGLRVPPHAPAHSALWRVLIVESNAMEAETLARGLRRHGHEVDIVGTGSEALRGYADADLVLLDLELPDLDGLEVCRGIRAAHEIPLIAVTARGSELDRVLGLQAGADDYLVKPYGFRELMARMEAVMRRARPSRPAAATITCGPLRIDAGTREVTLNGEPVETTRKEFDMLYLLASHPDTVIPRKMLMQQVWGDSWSRRTVDTHVSTLRNKIGANWIITIRGVGFRFGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP01</accession>
    <name>A0A0F4JP01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000273">
        <property type="protein sequence ID" value="KJY34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947345.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000273.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34666">
        <property type="protein sequence ID" value="KJY34666"/>
        <property type="gene ID" value="VR44_11520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="9833" checksum="84231CEC317F1008" modified="2015-06-24" version="1">MTQHPHRTATLQDLIASLGVLLVIPALVLRRAGRDGTHPDLVAGSWGLQGLALLAVLAGMSLALVRGSRPSPGMWVLLALWTAGTGTALLAPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPF9</accession>
    <name>A0A0F4JPF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946755.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36257">
        <property type="protein sequence ID" value="KJY36257"/>
        <property type="gene ID" value="VR44_08345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4568"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="49763" checksum="2F0416CB13BF89DC" modified="2015-06-24" version="1">MAVARRILPGWQDDEQRLLCRRWRGSWMRWNGTCWRELDEQQMRAGLYTRLEHATYTAGLDKDGNPEIRDWAPTKTKLSNLLDALGAITLLPTDVDPPSWTDPDQPNPGPTVACRNGLLRIRDRCLLEHGPGFFNLVAVPFDYDPAATAPNWEGFLRRLWPDDPASVAALQEWFGYVLSGRTDQQKILLMKGPTRSGKGTIARVMKELVGKENLAGPTLSGLGTNFGLASLIGKPLAVISDARLSGNDNGVVERLLTISGEDTIDIDRKYREAWTGKLPTRLMILTNELPSFGDASGVIARRFIVLSMTVSWLGKEDTGLDGKLAAEMPGILNWALEGLARLERTGRITQPASSQESITIMQDTASPTSAFVRERCATGPTCQVPVDTLWAVWREWAEDNGVKAIGTKQVFGRNLLSVVPQLHRTRPRDAYGQQVPTYTGITLNKPEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQI6</accession>
    <name>A0A0F4JQI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946684.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36440">
        <property type="protein sequence ID" value="KJY36440"/>
        <property type="gene ID" value="VR44_07975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4419"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14024" checksum="749314869ECD1A5C" modified="2015-06-24" version="1">MTIEWRYTTRQDLGVLSLAGYLGSEATDRFTGAIGWALARGTGPVILDLTGLLGWSAGGQIAIAQAARRLGENGRRLELAAIPADGSLVPDGTCAPVPVHCDLATALAAHGAGGTVKQWTTDDWPTGQSPEASALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRF8</accession>
    <name>A0A0F4JRF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_06860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000127">
        <property type="protein sequence ID" value="KJY36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946480.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000127.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36932">
        <property type="protein sequence ID" value="KJY36932"/>
        <property type="gene ID" value="VR44_06860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3456"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="365" mass="36889" checksum="D324DA42199F04C3" modified="2015-06-24" version="1">MTPQPATSGAAGGIGRRTAGHRLLWPALVLLALLLGNLAFHHDFFSVRVRDGHLYGSLVDILRFGAPLVLVALGMTLVIATRGIDLSVGSTVAIAGALACGHLAGAARPGSVAATLTAVGLALGVALVLGLANGLLVSGLGVQPIVATLILMVAGRGVAQLITDGQIVTVTSAPYKMIGGGYWLSLPFAVLLAAVLVALTSFVTRRSALGMLIESVGGNPTASRLVGIRAGGLLVLVYVFSALCAAVAGLMISSNVSSADGNNAGLWIELDAILAVVVGGTALTGGRFSLGGTVLGALVIQTLSTTVYTLGVPPETTLVFKAFVVIVVCLVQSPVFRAKAVRRRAATPRPPTTAGATPQEQEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS15</accession>
    <name>A0A0F4JS15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000202">
        <property type="protein sequence ID" value="KJY35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35746">
        <property type="protein sequence ID" value="KJY35746"/>
        <property type="gene ID" value="VR44_09310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="15969" checksum="FBB6FABF280B168F" modified="2015-06-24" version="1" fragment="single">MTTTAQQTTPDPTATLPLTDEDCLAETLAFNARFEAEAASRPARGAAPDAALLARLRRNRLAGDAPPVRLPQGRDRTVAGGVRVRTFMPDADGGGSPRGVYLHIHGGGWSFGSADGQDERLRRIAEEARLAVVSVDYRLAPEHPFPAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS28</accession>
    <name>A0A0F4JS28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_07565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946603.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36639">
        <property type="protein sequence ID" value="KJY36639"/>
        <property type="gene ID" value="VR44_07565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3990"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="8">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="35157" checksum="0CEAD3B959812B3B" modified="2015-06-24" version="1">MHVPDGFIDAPVSVAAGVAATAAVAVSLRGARRELDERTAPLAGLVAAFIFAVQMLNFPVAAGTSGHLLGGALAAILVGPYTGVLCVSVVLLMQGILFADGGLTALGVNILNMAVVTVLVSYAVFRVLLRLLPSGRRSVTVAAFAGALLSVPGAAVMFTLLYALGGTTDVPIGKVFTAMVGVHVLIGLGEALITAATVGAVIAVRPDLVHGARGLAAPLKLRIGGQLVDAPAAAPVPAAARSTRKLWLTGLVTALVLAGFVSFYASSSPDGLEKVAADKGIDAKTKEHAAADSPLADYSVKDVDDARLSGGLAGVIGVGATVAVGSGIFWAVRRRRAQDLTASSTAAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS65</accession>
    <name>A0A0F4JS65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946920.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5095"/>
    <dbReference type="EnsemblBacteria" id="KJY35796">
        <property type="protein sequence ID" value="KJY35796"/>
        <property type="gene ID" value="VR44_09250"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331A3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="21408" checksum="ECBAA218B4B07D32" modified="2015-06-24" version="1" fragment="single">MTSWTTASPRRFARREWGPLFWTLRDALVRDKWRAVPMTIGAVCLTSVFQIVQNTHWGFQPVQNLGSVKAVDPLWLALLRTPLSLFVPALDLPVWGALAQILLVFGIAEICIGWWRTLLIGYIATLAGTTYARIGLSLGPDHPFGLPVTDRVVNDTGPSAAVVGLALYVCWRYRAYFTGTLVILVMIGEVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT09</accession>
    <name>A0A0F4JT09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946316.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37320">
        <property type="protein sequence ID" value="KJY37320"/>
        <property type="gene ID" value="VR44_05990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2412"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16219" checksum="502E1358B03C2DA0" modified="2015-06-24" version="1">MTTTTGTLRTGHVGLNVTDLDRSLAFYRDALGFELLGEGKEEGRRFAFLGRDGELVLTLWQQAEGGYAPRAAGLHHLAFSAGAIEEVRAYEERLRGLGVDFAYEGVVAHREGSASGGIFFHDPDGTRLEISVPTGAEGATAPVESAPTCGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT48</accession>
    <name>A0A0F4JT48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000176">
        <property type="protein sequence ID" value="KJY36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36141">
        <property type="protein sequence ID" value="KJY36141"/>
        <property type="gene ID" value="VR44_08440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22002" checksum="7B10DC9E58C14576" modified="2015-06-24" version="1" fragment="single">PAPGNLRARLTTFVGREEDIRVIGSDLARARLVTLLGPGGAGKTRLSQEAAEAHPAGDWPDGVWLVELAPVDDPEDVAEAALAAVGARETKLRGAAAEELRALTDRTGDHPLDRLAEHCSRRRLLLLLDNCEHVIGAAAELAERILTQCPGVRILATSREPLGVPGELLRPVEPLPDPVALRLLGDRGAAAKPGFRVADDPEAAAEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT96</accession>
    <name>A0A0F4JT96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000123">
        <property type="protein sequence ID" value="KJY37044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946449.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000123.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37044">
        <property type="protein sequence ID" value="KJY37044"/>
        <property type="gene ID" value="VR44_06680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3254"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="26302" checksum="F3919C9E90D170E6" modified="2015-06-24" version="1">MSARGNKIAVVTGAGSGIGRSVALALAGAGWSVAVAGRRIQPLEETAAAAGEGADVLPVRADVSDPADVAALFGAVRERYGRLDLLFNNAGTFGPAGVPLEEIAYEDWRQVVDVNLTGAFLCAQGAFRVMKEQDPQGGRIINNGSISAHVPRPNSIAYTATKHAMTGLTKSLSLDGRPYRIACGQIDIGNAATDMTARMQTGILQANGQLAVEPVMDAADVARTVLHMAELPLEANVQFATVMATAMPYIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU21</accession>
    <name>A0A0F4JU21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">VR44_05220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946172.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3377"/>
    <dbReference type="EnsemblBacteria" id="KJY37660">
        <property type="protein sequence ID" value="KJY37660"/>
        <property type="gene ID" value="VR44_05220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1677"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="33175" checksum="343789F63B4D5FCC" modified="2015-06-24" version="1">MKLVFAGTPEVAVPALDALIASGRHEVAAVVTRPDAPAGRGRRLVASPVAERAEEAGIEVLKPVRPRDPEFQERLREIAPDCCPVVAYGALIPKSALDIPVHGWVNLHFSLLPAWRGAAPVQQSIMAGDQVTGASTFRIEEGLDTGPVFGVLTEEIRPTDTSGDLLTRLAFAGAGLLTATMDGIEDGSLRAVEQPAEGVSLAPKITVEDARVDWNAPALRADRVVRGCTPAPGAWTVFRGERLKLISVGLVPDRTDLEPGVLAPAKNNVYVGTGSHAVELLWVQPQGKKPMKGADWARGVRIAPGERLGGTDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU44</accession>
    <name>A0A0F4JU44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946082.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37882">
        <property type="protein sequence ID" value="KJY37882"/>
        <property type="gene ID" value="VR44_04735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="21919" checksum="37B47275D0D43746" modified="2015-06-24" version="1" fragment="single">MTQTTLLCVPFAGAGPSFFHPWRELAAGRWRVTSVELPGRERRILEEPYRNVQEAAKGVIDEVVADLGEGARTVLFGHSLGAVLAYELAHLLAERGVRVERLVVSGSPGPWTQRERRAAGLPDEEFLARVEEFAGFRHEALDHPEMRELILPVLQADCEMHESYVPSTDVPLAVPICSLRGADDGLVTAEEARQWQGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU85</accession>
    <name>A0A0F4JU85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946158.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37730">
        <property type="protein sequence ID" value="KJY37730"/>
        <property type="gene ID" value="VR44_05135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1342"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7134" checksum="20274CAEF19435CE" modified="2015-06-24" version="1">MSASPRRACPSCGRDCAVTAGRIARHDPPAGRRAGLVSCPGSRARVVLGATAPTLDGFVLGPHPGQLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUU2</accession>
    <name>A0A0F4JUU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946203.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37599">
        <property type="protein sequence ID" value="KJY37599"/>
        <property type="gene ID" value="VR44_05390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1714"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="20525" checksum="DEEF81512D4DDE6C" modified="2015-06-24" version="1">MRTGVIGTGRIGSTLARILVAAGHEVVLANATGPESLAPLLAELGPAAGAARPVEAAGRADLLVLMVPYASVRGLLPPHVVQDKVLVDATNAFSGPGTPADLGGRGSSELVADWYPGARVVKSLNTMHYETLAVAGKAAGERLAHYTAGDDPKAKEIVAGIITDLGFAAVDTGPLHSGGILQQPGGPLFNRSLTEAQALAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV12</accession>
    <name>A0A0F4JV12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946191.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37679">
        <property type="protein sequence ID" value="KJY37679"/>
        <property type="gene ID" value="VR44_05360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1708"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16213" checksum="1BABBFC6E6C239CF" modified="2015-06-24" version="1">MVELARKPAVLEVPATLGALGEIAEFVLRLAARARLGTGATYRIRLAVDELATNIVMHGYRGGEGRITVLGRSGPDGVRIVIEDTAPAFDPVAGRLPPPPGIPPERRRVGGLGIHLALTSVDEYTYVRRDGRNISTLTVKAEGTDDVCPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV48</accession>
    <name>A0A0F4JV48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">VR44_03960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042810017.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene752"/>
    <dbReference type="EnsemblBacteria" id="KJY38237">
        <property type="protein sequence ID" value="KJY38237"/>
        <property type="gene ID" value="VR44_03960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8697"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8674" checksum="8BF14199BEBEBC48" modified="2015-06-24" version="1">MLEEALEHLVKGIVDNPDDVQVASRNLRRGQVLEVRVHPEDLGKVIGRNGRTARALRTVVGAIGGRGIRVDLVDVDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV73</accession>
    <name>A0A0F4JV73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946170.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37744">
        <property type="protein sequence ID" value="KJY37744"/>
        <property type="gene ID" value="VR44_05195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1354"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="31861" checksum="3E01B88CCC0F47D6" modified="2015-06-24" version="1">MPVLGADAAVGRSRHGDPLMRRTLRSLRGALGSSAAKAVASETGLATQVQQPVTTGRHIVVTSIRGGSGKTTVTALLSRTYNHFRHDPVLTLEADAALGTLPVRLGVESLRWTCGDLAQIVRPSMQLTDITGYLVPLPDGGWLLPGSQGRIGAQVDVATYRTVMVALRRYFGVTVVDCETLPGEVARTALDTAHARVLTTPATAEGLVSTHAVLDWLASLPVPVLPRTVVVLTVQSPHPAVDLAKATAKLAATGAGVVVLPYDRHLASGGAVRTDLLGEGTRQATVRLAAEVLQRAVALPAAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVW1</accession>
    <name>A0A0F4JVW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946062.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37964">
        <property type="protein sequence ID" value="KJY37964"/>
        <property type="gene ID" value="VR44_04645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1010"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="55"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="46624" checksum="4914697BE849BB39" modified="2015-06-24" version="1">MGHCPQDDRGGPDPHLGRYAARTAGMTASEIRALFAVASRPEVVSLAGGMPHLAALPLEELAAQSARIIAEEGLTALQYASAHGLPLLREQICEVMALEGVAARPDDVVVTVGSQMGLDLVARLFCDPGDVVVAEGPSYVGALGSFAAYQAEVVHVPVDGHGLVPDGLRAALRQARNAGRRVKLLYTVPNFHNPSGVTLAAGRRAEVLEICRASGVLVVEDNPYGLLGFDGRVRPALHSLDPENVVYLGSFSKTFAPGLRVGWVLAPHPVREKLVLAAESAMLCPPTLNQMIVSRYLATQDWRGRIESFREIYRERRDAMLDALEEYLPPGCTWTEPDGGFYVWVKVPEGVDTKAMLPRAVAARVAYAPGTGFYTNGLGSRRMRLSYCYPTPERIREGVRRLAAVLEAEPALAHASAAAGPGRTAGRRALAPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX83</accession>
    <name>A0A0F4JX83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000040">
        <property type="protein sequence ID" value="KJY38967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945694.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38967">
        <property type="protein sequence ID" value="KJY38967"/>
        <property type="gene ID" value="VR44_02590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6822"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="544" mass="58166" checksum="0540C228FF419375" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYD3</accession>
    <name>A0A0F4JYD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945777.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a0f4jyd3">
        <property type="family name" value="Duf_1023"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38748">
        <property type="protein sequence ID" value="KJY38748"/>
        <property type="gene ID" value="VR44_02985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7329"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="39966" checksum="EA4916F78E6F3D0D" modified="2015-06-24" version="1">MLLALGVVFLMLATTGWTAVHRPDTAVPARAAALAAWATARIDGRPVPAADAPVRTVARFFAGLDAAQRTRLADGYPLVVGTLDGVPAETRYRANHNALTQAAKLEEARGKDVALTPADRANAIRRAHRFESLAEDGRQILLFDPSGDGLVAEVYGDLDAARRVSVIVPGVDTDALTFERSQRRLIAPAGMAQSLYEAERAAAPAARTAVIAWAGYVAPAGVGVDAATGRLAVQGAVRLESLTAALPGNASVALFCHSYGSVVCGVAARRLPDRVTDVVVAGSPGMRVGNAAELHTAARVWATRAEGDWIADVPHLEVGGLGHGADPVSPAFGARLLSSEGAHSHTGYFEPGTASLANFAKIGTGGFGSVACANGNADCRGGISGTDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYE8</accession>
    <name>A0A0F4JYE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945520.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39412">
        <property type="protein sequence ID" value="KJY39412"/>
        <property type="gene ID" value="VR44_01655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5732"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="42137" checksum="ED5098A6AF19D34A" modified="2015-06-24" version="1">MSAPVGSDRPFLNRRLAAFGTTIFAEMSALAARTGSINLGQGFPDTDGPAEIAEAAVRAIRDGRGNQYPPGPGVPELRRAIAAHQQRFYGLGYDPDTEVLVTAGATEAIAAALLALLEPGDEVIALEPFYDSYAACIAMAGAVRVPLTLRAPDFRPDLDALRDAITPRTRLLLLNTPHNPTGTVLTREELAAIAELAVERDLLVVTDEVYEHLVFEGGHTPLASLPGMRERTVTISSAGKTFSFTGWKVGWITAPPALVSAVRSAKQFLTYVSSGPFQYAVAEALALPDPYYEAFRADLAAKRDLLTEGLTAAGLRVFRPQGTYFITTDISPLGEKDGLAFCRSLPERCGVVAIPNQVFYDDVEAGATQVRWAFCKKTEVLREAVDRLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYV4</accession>
    <name>A0A0F4JYV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945460.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39552">
        <property type="protein sequence ID" value="KJY39552"/>
        <property type="gene ID" value="VR44_01325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2981"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470976" evidence="2">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="10104" checksum="29093DBD1AC7B323" modified="2015-06-24" version="1">MASIRTARVIAAVASLPLAAALFGGVASADNGSFANDGSNASVASVIGSGVGGNNHGNSSTSQQVATGAGASNQNNTAQVNGSAYTAIHQANPNVAVNFFPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ70</accession>
    <name>A0A0F4JZ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39702">
        <property type="protein sequence ID" value="KJY39702"/>
        <property type="gene ID" value="VR44_00740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2853"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="29355" checksum="4361F50B5D633B6E" modified="2015-06-24" version="1">MVAPSAPSEGRAARRRAAQEAAKRSHARARKRGGRGRRRARPRSGGPVVVLSRALGELFITVGVVMLLFVAYQLWYTNLLAERTASGAAGSLRQTWENPPAAAAPPVAAFEPGQGFAILHIPKLDLKVPVAEGVSKAKVLDKGMVGHYSEGALKTAMPSDQQGNFALAGHRNTHGEPFRYINQLVPGDPIVVETRDAYYTYKMTSVLPQTSPANVSVIKPVPEGSGFPGPGRYITLTTCTPEFTSTYRMIVWGRMVDERPRSQGAPPALNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZY4</accession>
    <name>A0A0F4JZY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">VR44_00255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945283.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1010"/>
    <dbReference type="EnsemblBacteria" id="KJY39927">
        <property type="protein sequence ID" value="KJY39927"/>
        <property type="gene ID" value="VR44_00255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.49"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="710" mass="77644" checksum="3071B3FD6CEB8C19" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZZ4</accession>
    <name>A0A0F4JZZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">VR44_00305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007265905.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1029"/>
    <dbReference type="EnsemblBacteria" id="KJY39937">
        <property type="protein sequence ID" value="KJY39937"/>
        <property type="gene ID" value="VR44_00305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.59"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="30261" checksum="90DFB9B7EED369F0" modified="2015-06-24" version="1">MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMMTSGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPELDAQLVAQAVAEQLSSRVSFRRAMRKSMQGTMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPARGAGAGDRPAGRGGRGGERGGRGGRKPQQAAGAEAPKADAPAAAPAESTGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0D5</accession>
    <name>A0A0F4K0D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000054">
        <property type="protein sequence ID" value="KJY38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945781.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4914"/>
    <dbReference type="EnsemblBacteria" id="KJY38711">
        <property type="protein sequence ID" value="KJY38711"/>
        <property type="gene ID" value="VR44_03040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7340"/>
    <dbReference type="eggNOG" id="COG2899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="378" mass="40863" checksum="E94C933AB90EEA3E" modified="2015-06-24" version="1">MVLKTFGWSFAVTALGLAAAVFYGGWTAFGIVAILSILEISLSFDNAVVNAGILKKMNAFWQKIFLTVGVLIAVFGMRLVFPVVIVAISAKIGPLDAVDLAMNDKEMYQQLVTDAHPSIAAFGGMFLLMIFLDFIFEDRDIKWLAWLERPLAKLGKIDMLSACIALIVLVITSMTFATQAHQHGGAHVDKAQTVLVSGILGLITYMVVGGLSGYFENRLEEEEEAEHEAEEAAKKSGKPVSAVVMAGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVLMALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAVILLVTIQYEINEVITGLVGVVLIAWSFWSSVRRNKRLEAEGGDGEPAEAVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1A4</accession>
    <name>A0A0F4K1A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945357.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4795"/>
    <dbReference type="EnsemblBacteria" id="KJY39703">
        <property type="protein sequence ID" value="KJY39703"/>
        <property type="gene ID" value="VR44_00745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2854"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22633" checksum="381D371AEF75F4C1" modified="2015-06-24" version="1">MSARILVVDNYDSFVFNLVQYLYQLGAECEVLRNDEVELAHAQDGFDGVLLSPGPGTPEEAGVCVDMVRHCADTGVPVFGVCLGMQSMAVAYGGVVGRAPELLHGKTSPVVHEGLGVFSGLPSPFTATRYHSLAAEPQTLPDVLEVTARTEDGIIMGLRHREHDVEGVQFHPESVLTEWGHRMLANWLVRCGDAGAVARSEGLAPVVGKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1L1</accession>
    <name>A0A0F4K1L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945632.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39106">
        <property type="protein sequence ID" value="KJY39106"/>
        <property type="gene ID" value="VR44_02240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5713"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="25584" checksum="F2323F590ED952AB" modified="2015-06-24" version="1">MNTVSPRALLVRGMLAGLLAGVAAFLVAYLLGESKVDAAIAIEEAGEAAHDHAEAAPVSRALQATAGLGTGTLLYGIALGGIAALVFCFALGRIGRFGPRATAALVSGGLFLTVGLVPFLKYPANPPAVGDPDTVVRRTTLYLLMIALSVLLASGALILGRRLAPRLGNWNASVLASVAFVAAVGTAYALLPAVNEVPEDFPAALIWQFRLASLAIQAVVWTTFGLAFGFLAERAIAPAAAPKEAVQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2Y0</accession>
    <name>A0A0F4K2Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39541">
        <property type="protein sequence ID" value="KJY39541"/>
        <property type="gene ID" value="VR44_01250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2966"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="55" mass="6326" checksum="3A7B5977F78855AE" modified="2015-06-24" version="1" fragment="single">TVARRRPSLAEHGRGLHLIAELADHVRLRNRPGRGAVVSFERMLKWREDALLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K4F6</accession>
    <name>A0A0F4K4F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_00070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945257.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40061">
        <property type="protein sequence ID" value="KJY40061"/>
        <property type="gene ID" value="VR44_00070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.15"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="7"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY40061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="475" mass="48284" checksum="3F3C609624F57E56" modified="2015-06-24" version="1">MPGAGSFRADLGASVVVALVALPLCVGVAVASGVPAELGIVTGVAGGLVTGWFRGSELQVSGPAAGLTVLVYEAVGTYGLPALGVLVLAAGMVQLGLGALRLGRWFRAISLAVVHGMLAGIGLVLIAGQLYALGGVRAPGQTLAKLGGMHELGAQADWAAVALGAGTIAVMVLWRRVPTGLRVVPGALVGVAAATAVAALLRLPVETVRVTGVLEAVSPPGWSDFGALGSVGAVGTVVALALIASAETLFSAAAVDRMHEGPRTDYDRELVGQGVGNAVCGLLGALPMTAVIVRSSANVEAGARTRASRILHGGWLLLFAVALPQVLAVVPLAALAGVLLHAGWKLLPARAVAALWRTHRGEAVVLVVTAGSILATSLFEGVLVGLVLAVAKAAWETSHVHVEAVWEGEELCVRVVGNASFLRLPKLLDSLEALPHGPSVRLDLSGLRHLDHACLTALEGWERKRMPLPGREGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3F5</accession>
    <name>A0A0F4I3F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001805">
        <property type="protein sequence ID" value="KJY15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15983">
        <property type="protein sequence ID" value="KJY15983"/>
        <property type="gene ID" value="VR44_40660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="10646" checksum="FD7F1CA890724DA7" modified="2015-06-24" version="1" fragment="single">GAAVWAGAGAGRPERVAGAALLVAPDASWTGLLLGLSVPVRGRAGGGLGRLLPPLSRGEPVTVARLAEYDGRAWLLVAGAGVLLLYAGVRAAVRSPGRGVAACAAWXG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5H5</accession>
    <name>A0A0F4I5H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001683">
        <property type="protein sequence ID" value="KJY17222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952624.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001683.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17222">
        <property type="protein sequence ID" value="KJY17222"/>
        <property type="gene ID" value="VR44_40080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16623" checksum="C1195C2626E30143" modified="2015-06-24" version="1" fragment="single">MNRTRTSAAPRPTAGALRLVEASTTAPATIHISAYVRQMTAHCPYLAPSLQQGLTTWTVYGAEGDPAAVEAELFHAGVQAAEWLRPLLNRPHGSLRCENIVLLGDAPGARHRDLLAWPHWVLKNLYGPVGIMFGKFHAGEEETTRAGARIPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAX1</accession>
    <name>A0A0F4IAX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001585">
        <property type="protein sequence ID" value="KJY18819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18819">
        <property type="protein sequence ID" value="KJY18819"/>
        <property type="gene ID" value="VR44_39410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5970"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="12514" checksum="91CA3BEB2B9F26B4" modified="2015-06-24" version="1">MLEKIRVPRIGPGRPRKKSDSLAADKAYSDGPCREYLRRRGIRHTIPEKTDSQAARLRKGSRGGRPPGFDEERYKKCNTVERAINQLKHARAVATRYDCEDVQVPLRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBC1</accession>
    <name>A0A0F4IBC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001557">
        <property type="protein sequence ID" value="KJY19302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19302">
        <property type="protein sequence ID" value="KJY19302"/>
        <property type="gene ID" value="VR44_39165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="10185" checksum="2F7A00FCB88ECFD5" modified="2015-06-24" version="1" fragment="single">MKAETVAGDGETLALTGREGADAEARSLAGREPGPAGAEPEPGTGTEGAPVAAAGTPAYGEGDTAAREASDGTDRLAPAGQEPAGIDEPATERKSDAAEPEPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBG5</accession>
    <name>A0A0F4IBG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001556">
        <property type="protein sequence ID" value="KJY19347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19347">
        <property type="protein sequence ID" value="KJY19347"/>
        <property type="gene ID" value="VR44_39160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5596"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15204" checksum="05EBD193B86884B1" modified="2015-06-24" version="1">MMEFRVDRRSGVATYLQLVTQVKQALRLGVLEPGDRLPTAREVVAATAINPNTVLKAYRELEREGLVEPRPGAGTFVRRSLSHPQAAADSPLRTALADWTARAREAGLGREDITALIAAVVEESFNRSGPEPGPSREDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICR1</accession>
    <name>A0A0F4ICR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="10" type="ORF">VR44_38970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001536">
        <property type="protein sequence ID" value="KJY19807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952422.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19807">
        <property type="protein sequence ID" value="KJY19807"/>
        <property type="gene ID" value="VR44_38970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5511"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="9">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY19807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="32210" checksum="E2A6D71C412F6BAB" modified="2015-06-24" version="1">MSTAEQQQPHGTPQAPEAPSDALLGPADIRELAAALGVRPTKQKGQNFVIDANTVRRIVRTAEVRPDDVVVEVGPGLGSLTLALLEAADRVVAVEIDDILAAALPATIAARMPQKKDRFALVHSDAMLVTELPGPAPTALVANLPYNVAVPVLLTMLDRFPSIERTLVMVQAEVADRLAARPGNKVYGVPSVKANWYADVKRAGAIGRNVFWPAPNVDSGLVSLVRRAEPIATSASKAEVFAVVDAAFAQRRKGLRSALAGWAGSAAAAEAALTAAGISPLARGESLTVEEFAAIAEHKPADAQKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICR2</accession>
    <name>A0A0F4ICR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">Histidine ammonia-lyase</fullName>
            <shortName evidence="5">Histidase</shortName>
            <ecNumber evidence="3 5 7">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hutH</name>
        <name evidence="9" type="ORF">VR44_39575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 5 7"/>
    <dbReference type="EMBL" id="JZWV01001606">
        <property type="protein sequence ID" value="KJY18421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952537.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001606.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5516"/>
    <dbReference type="EnsemblBacteria" id="KJY18421">
        <property type="protein sequence ID" value="KJY18421"/>
        <property type="gene ID" value="VR44_39575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6027"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="5">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY18421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="513" mass="52940" checksum="3B4E08EA0EC73BD5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH62</accession>
    <name>A0A0F4IH62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001471">
        <property type="protein sequence ID" value="KJY20999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952319.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001471.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3730"/>
    <dbReference type="EnsemblBacteria" id="KJY20999">
        <property type="protein sequence ID" value="KJY20999"/>
        <property type="gene ID" value="VR44_38420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5334"/>
    <dbReference type="eggNOG" id="ENOG5033UMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="28189" checksum="CAB205634080542B" modified="2015-06-24" version="1">MAEAVPVRCPACQRENGYISPVFPCACGSPVTPPLDPAAAPLPLTHRTWQDSWVTVRCGACGRESEWPHPEVGCGSCGTVVLVPVLPPEPPASAVEEEPGAGAGAESGAPGAGSGVRRDGGPSGPVPAGAASRSPGPAGAAGGRGRGPASRPPFRPVTIRTARDAVATAALYLRWLGFRDVRQPDGVPIPSAAVDLRAPGVVAQVDPTTAPAGLRAVECVWLNGLTASATSVYFALAGYTEEARSRADDLGIPLFVMDLTGMPQPLNDPADALVGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP53</accession>
    <name>A0A0F4IP53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001357">
        <property type="protein sequence ID" value="KJY23807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030235830.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001357.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3093"/>
    <dbReference type="EnsemblBacteria" id="KJY23807">
        <property type="protein sequence ID" value="KJY23807"/>
        <property type="gene ID" value="VR44_37205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4832"/>
    <dbReference type="eggNOG" id="ENOG5030Z5E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="14353" checksum="9E30866BF812B3E2" modified="2015-06-24" version="1">MSLDVSPALLEQAERGEVDEAAFVDCVRTSLPYAWEMISSLTAQLEVEGGEFADNQTPPPDEQARGQLLRALASDAIRGALQRHFGVRLAFQNCHRVAVFPLDPSVDDRLAKFTSIRGQLLNQSPELRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQM6</accession>
    <name>A0A0F4IQM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001322">
        <property type="protein sequence ID" value="KJY23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952006.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001322.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23959">
        <property type="protein sequence ID" value="KJY23959"/>
        <property type="gene ID" value="VR44_36740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4657"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="471" mass="47612" checksum="84D9BFEDFA0CE50A" modified="2015-06-24" version="1">MTTDIQTPAVTGPRTAAPEDTRLSGRARLVLFVLCAAQFMVALDFSVLNVALPVLGKDLQLSPSALQWAVTAFSLPSGGFLLLFSRIGDLFGRKKLFLAGLALFGAASLLATVAWNPAAFLTGRALQGLGAAAVVPAGMSLLTTTFPEGPLRDRALGISGTLLSLGFTVGMVLGGVMTDTLGWRSTMGLLAVAALVVLVLAPGLLAESRTPERPRLDVPGAVTVTAGLLALIYALSTAAERGFGGLDVQASLVAGLVLLAVFVVVESKSAAPLVSLPMLGRRTVAWGNVGGLVTFSMMSTVIFVLTLYFQETLGLSSFLTGLVFGVQGIASALAGSLAPRFIGRFGARRTLVGSLAGQGLFTAALLAVGPDSGALVATVAVSLASMCHLGAIISYGLTVTSGVPDGEQGLATGLVTTTQQVGLTVGIPLLGVLATTGTSLFGGVRTVLAVDAALVVGAALLVAAGLGRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQS0</accession>
    <name>A0A0F4IQS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001313">
        <property type="protein sequence ID" value="KJY24004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951978.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24004">
        <property type="protein sequence ID" value="KJY24004"/>
        <property type="gene ID" value="VR44_36595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4627"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="36580" checksum="440412F88F8901D2" modified="2015-06-24" version="1">MRRPRLPARFPLDPYVLALLATVGLAALLPARGPAATVADGASTAAVALLFFLYGARLSTREALDGLRHWRLHLTVLACTFVLFPALGLAARALVPTLLTQPLYNGLLFLCLVPSTVQSSIAFTSIARGNVPAAICAGSFSSLAGIALTPLLAGALLGGDGGGFSAGSLLKIVVQLLLPFLLGQLLRPWTGGFLTRRKKVLGYVDRGSILLVVYAAFSAGVAAGVWHRVSLPRLGALMAVEAVLLALMLLVTWYGSARLGFGRADRIAIQFAGSKKSLAAGLPMASVLFGAQASLAVLPLMLFHQMQLMVCAVLARRRAADPDTPDSGQLPDGPVAEVSPRPQHPAAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQS4</accession>
    <name>A0A0F4IQS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">VR44_36580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01001312">
        <property type="protein sequence ID" value="KJY24009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951976.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24009">
        <property type="protein sequence ID" value="KJY24009"/>
        <property type="gene ID" value="VR44_36580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4624"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="223"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="240"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY24009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="32287" checksum="2DAB08929A4C4152" modified="2015-06-24" version="1">MTGSRVVALGHYQPAKVLTNEDLAGMVETSDEWILSRVGIRTRHIAGPEEPVDELAHQAAAKALANAGLSPDDIDLVLVATSTAIDRSPNTAARVAAKLGMAGAPAVMDLNVVCSGFTHALATADHAIRAGSATRALVIGADKMAEITDWTDRTTCVLTGDGAGAAIVEASAEPAIGPVLWGSVPEMGHAVRIEGTPPVFAQEGQSVYRWTTSRLPALARKTCEKAGITPEELAGVVLHQANLRIIEPLAAKIGAVNAVVARDVVDSGNTSAASIPMALSKLVERGEIPSGAPVLLFGFGGNLSYAGQVIRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRZ2</accession>
    <name>A0A0F4IRZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001171">
        <property type="protein sequence ID" value="KJY24772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951558.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001171.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24772">
        <property type="protein sequence ID" value="KJY24772"/>
        <property type="gene ID" value="VR44_34335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3844"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="523" mass="57740" checksum="146AB54E586096F0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS51</accession>
    <name>A0A0F4IS51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001159">
        <property type="protein sequence ID" value="KJY24850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24850">
        <property type="protein sequence ID" value="KJY24850"/>
        <property type="gene ID" value="VR44_34175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="308"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="710"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="834" mass="89163" checksum="F5C0D8CC23499A99" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW2</accession>
    <name>A0A0F4ITW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001122">
        <property type="protein sequence ID" value="KJY25089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25089">
        <property type="protein sequence ID" value="KJY25089"/>
        <property type="gene ID" value="VR44_33430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3565"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="54" mass="6221" checksum="901F28EF70D0A4DD" modified="2015-06-24" version="1" fragment="single">RLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIERGLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU97</accession>
    <name>A0A0F4IU97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor biosysynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001106">
        <property type="protein sequence ID" value="KJY25219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951326.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001106.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25219">
        <property type="protein sequence ID" value="KJY25219"/>
        <property type="gene ID" value="VR44_33075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3487"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="122"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28776" checksum="ED5FE7F4EAFBEBE9" modified="2015-06-24" version="1" fragment="single">VQSLHVHPVKSVGGTAPDAMAMDPWGPADDRRWAVVDPTGTVITQRQQARLALASSRPLAGGRIALSAPGMPDLVVEVPEPGPLEPVVLFGKKVDTVVASAAAAEWFTSYLGVPARLVHLDDPAVRRPVDPDYALPGETVSLADGYPVLLVTTASLEALNALIAEGDHPEEGPLPMSRFRPNLVVDGPLEAWAEDGWRRIAIGGAVFRGVRECGRCIVTTTDQATAERGREPLQTLARHRRIGKSLAFGRLLVPVVPGTVRVGDEVRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV59</accession>
    <name>A0A0F4IV59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001205">
        <property type="protein sequence ID" value="KJY24556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951682.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001205.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24556">
        <property type="protein sequence ID" value="KJY24556"/>
        <property type="gene ID" value="VR44_35015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4077"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19360" checksum="B11EB60E622A1E2C" modified="2015-06-24" version="1">MSLYEDAVLVLKDYEGRDEQQRGLRDVYLEHLAEHPDGMYKPCQAGHVTGSALVIDPVGGRVLLTLHKKLGLWLQMGGHCEPGDSTLAGAALREAVEESGIPSGLTLLEGGPVRLDKHPIPAPCNWHLDVQYAALARAGATAEISDESLDLRWFPYAEVAAVADTSVVRLVEATLARLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVI6</accession>
    <name>A0A0F4IVI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951206.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25473">
        <property type="protein sequence ID" value="KJY25473"/>
        <property type="gene ID" value="VR44_32420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3287"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24720" checksum="99D795A58575AD9E" modified="2015-06-24" version="1">MPQPSAPRKAPGRPARISREEIIDTARRIVAEGGVKGLTMRRLAAEVGSTPMAIYHHVRDKEELLVLLLDDYAARTLRRSRLPADSRERVVAAAGAVHDALAACPWIVEVLTADDLMSTSALWFVEQIVDGLVECGLPLDRAVHGYRAIWYYTAGEIVVRATAARRRADDDRATYREHVFADLDPAELPRLAQASERWAALTAEDTYEDGLRALVDGLLAGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVL4</accession>
    <name>A0A0F4IVL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001036">
        <property type="protein sequence ID" value="KJY25679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951102.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25679">
        <property type="protein sequence ID" value="KJY25679"/>
        <property type="gene ID" value="VR44_31855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3085"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469852" evidence="2">
        <location>
            <begin position="37"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="514"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="613" mass="65928" checksum="38731181CA731EFE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWB4</accession>
    <name>A0A0F4IWB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001028">
        <property type="protein sequence ID" value="KJY25758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951071.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25758">
        <property type="protein sequence ID" value="KJY25758"/>
        <property type="gene ID" value="VR44_31690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3047"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470317" evidence="2">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="34054" checksum="4C93270D49950715" modified="2015-06-24" version="1">MLDLPRLRALHAVSVHGSVAAAAAALGYTPSAVSQQIGKLERETRTTLLERRGRGVALTEEARHLAETARELLAIVERAETTLEERRGLPGGRLTVAAFASAARGLLPGVLADLAVRHPALDVRLTEVDPHLSVDLVARGVTDLAVAHDWDIAPLPAPEGVEHALIGDDRCDLVVPAGHPFTARRLVRRADLGGQRWVCQPPGRVCHDWLVRTLRTAGFEPEVAHMAEENHTIVALVAAGLGIAVVPRLGTGRLPPGAVAVPLEPVPVRRLYALWRTGASRRPAITETVRTLREHWPAVSGLLPGDAAGVPGTRGADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY10</accession>
    <name>A0A0F4IY10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IolB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000928">
        <property type="protein sequence ID" value="KJY26539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950731.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000928.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26539">
        <property type="protein sequence ID" value="KJY26539"/>
        <property type="gene ID" value="VR44_29805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2341"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="26831" checksum="42842C0F2E52A2B2" modified="2015-06-24" version="1" fragment="single">SRESGRGGVGESPAGTFELRGRHSVFDGPTDFVYLPRDTSARLTSAGGGRFALVGARCERRLPPRYGPAADVPVELRGAGQCSRQVHNFAAAGAFDCDRLIAVEVLTPGGNWSSYPPHKHDEHHPGEESRLEEIYFYEIAPHGDTPGVGYQRVTPSPAGKTDVLAEVRTGDVVLIPDGWHGPSIAAPGHDMYYLNVMAGPDAAREWLIRDHPDHAWIRGTWAGQEVDPRLPLNRPAPPAPRPEEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY78</accession>
    <name>A0A0F4IY78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000917">
        <property type="protein sequence ID" value="KJY26619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26619">
        <property type="protein sequence ID" value="KJY26619"/>
        <property type="gene ID" value="VR44_29625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2305"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="PTHR33973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18266" checksum="CBAE7B0DA0B8F6BB" modified="2015-06-24" version="1" fragment="single">RVLMLAHARVLGHVFNPLTLYWCHDGSGGLVCVVAEVHNTYGERHCYLLRPDAGGGAEVAKEFYVSPFFGVEGSYRMRLPLPGERLDLTVQLRHADGSRPLTATVRGTHRPATPRALLAALLRNPWPTAGVSFGIRRHGIRLRLKGLPVRPRPTRPARPVQEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY80</accession>
    <name>A0A0F4IY80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950518.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26985">
        <property type="protein sequence ID" value="KJY26985"/>
        <property type="gene ID" value="VR44_28665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2064"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469941" evidence="2">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="8255" checksum="5191BDD648174250" modified="2015-06-24" version="1">MKQSAAKSLGVAVIGAALAAGAAGTASASALPTPNLTDALGTVTSATSSITNQTDAAQQGQEGQASDPAAPVNQLLGGVPALGGLGGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYQ6</accession>
    <name>A0A0F4IYQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001022">
        <property type="protein sequence ID" value="KJY25806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25806">
        <property type="protein sequence ID" value="KJY25806"/>
        <property type="gene ID" value="VR44_31570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2810"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="14091" checksum="F3765F1CDC1B57FC" modified="2015-06-24" version="1">MGSMGDEVGEAIAGELRLMDPSVRMSRALARQLLDPHFVEVGASGRRWTYEEMLAALPEMTGAAEDGPRYEPSEMVGVVLAPGLVHLTYETTIDGNRARRSSLWRRRGAEGEWRMYYHQATPVPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYS9</accession>
    <name>A0A0F4IYS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000916">
        <property type="protein sequence ID" value="KJY26623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26623">
        <property type="protein sequence ID" value="KJY26623"/>
        <property type="gene ID" value="VR44_29615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2303"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14642" checksum="B85C7E8134F90491" modified="2015-06-24" version="1" fragment="single">YSRNPTVLHRDTTVLPRGRHARASWNYRLPSCSARPGAVQVSYDMNRLQRLPGDEPHIVTLNPGDRLDESRVLARMVYEHPLHAAESVAAQRLLPTLNDGVTAYAGAYHGWGFHEDGCRSGAEAARSLGVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYT5</accession>
    <name>A0A0F4IYT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">VR44_28320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000864">
        <property type="protein sequence ID" value="KJY27162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950451.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000864.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5088"/>
    <dbReference type="EnsemblBacteria" id="KJY27162">
        <property type="protein sequence ID" value="KJY27162"/>
        <property type="gene ID" value="VR44_28320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1910"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="509" mass="51695" checksum="7D4B152A0253F365" modified="2015-06-24" version="1">MTALTLSTAGAATLRADALVVGVAKGPKGLVVAAGAEAVDTAFDGKLAAMLDALGASGAEGEITKLPSPAGLKAPVVLAVGLGSAPELDESFDEEALRRAAGSAARALHGSKKAAFALPLEDASAVTAVAEGALLGAYAFTAYQGGDKKAAKNGGPKQPLAEVALLGAKPRDKEHKAAAERATVVATEVNVARDLINTPPNDLTPAAFAAIAAATAKELGLKAQVLDEKALIKGGYGGIMGVGKGSENPPRLVKIAYTHPEAEKHLAFVGKGITYDSGGISLKPAGHNETMKCDMSGAAAVFSSVVAAAKLGLKVNVTGWLALAENMPSGSATKPGDVLRMYSGKTVEVLNTDAEGRLVLGDALTKASEENPDAIVDVATLTGAMVLALGDRTFGIMANDDAFRTSIHEIAEEVGEASWPMPLPEDLRKTMDSPTADMANMGVRMGGGLVAGLFLREFVGEGITWAHLDIAGPAFHEGAPYGYTPKGGTGSAVRTLVRLAERTATGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYY4</accession>
    <name>A0A0F4IYY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser or Arg-related nuclear matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950415.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27235">
        <property type="protein sequence ID" value="KJY27235"/>
        <property type="gene ID" value="VR44_28100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1863"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="28191" checksum="F0B91107E506A81E" modified="2015-06-24" version="1">MSGGPGGPTVFDPYTLPSDDNVNKYTFCVELKGNQWFLQKGKMISYYGRIEFNGIGHGRFDRLLRTSFHSPLHASDWVVAEGQGKMLLADRAFDVNSYDLDDGNLTIRSGNLLAYQPSLALKQSIVPGFLTLIGTGKFVAASNGPVVFMEPPLRVDPQALVGWADCPSPCHHYDHGYMSGVIGGLRALTGLGGASGEEHQFDFVGAGTVLLQSSETLMAEQSVGVVGAGAATGNAQGVPGAGQGPLGQLGVPRMPGQLGDLQRRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0L9</accession>
    <name>A0A0F4J0L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_30045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000939">
        <property type="protein sequence ID" value="KJY26446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26446">
        <property type="protein sequence ID" value="KJY26446"/>
        <property type="gene ID" value="VR44_30045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2393"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470012" evidence="3">
        <location>
            <begin position="32"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="36"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="26148" checksum="D446A43ABBAE50C6" modified="2015-06-24" version="1">MSTLATTLKRGLAVGAVALAAVSLQPAGASASPTPVVGGTRAAQGEFPFMVRLSMGCGGALYTQQIVLTAAHCVNGSGNNTSITATAGVVDLQSSSAIKVKSTKVLQAPGYNGQGKDWALIKLAKPINLPTLKIADTKAYDSGTFTVAGWGAAREGGAQQRYLLKATVPFVSDAACQAAYGDSLVPSDEICAGYDQGGTDTCQGDSGGPMFRRDDTNAWIQVGIVSWGEGCARAGYPGVYSEVSTFAADIRNAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1B6</accession>
    <name>A0A0F4J1B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000767">
        <property type="protein sequence ID" value="KJY28057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28057">
        <property type="protein sequence ID" value="KJY28057"/>
        <property type="gene ID" value="VR44_26190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470032" evidence="4">
        <location>
            <begin position="31"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="227"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41742" checksum="DEB542EB8A8F10CE" modified="2015-06-24" version="1">MTNRLLGCGISCLAAAALLVTAAPPPPARAEPVGELLTRLQGLYQQAEEAAETYNATEVALKARQTEEQRLSSALGRTRSALDSERATAGRLAREQYQGLRGGGLSPYLRMLLSGDPQQALDQRHLAAREGARRAGVVARLERDRKQAGALADAARKALEAQQALAARQKEAQREVTGRLKEVERLLASLTPAELAGLGAREAAVTAGAQRSLLDSGRLPARTTPPTAAGSSALRYAAAQIGKPYVWGAEGPASFDCSGLTSQAWEHAGRSIPRTSQEQWAQLPRVPLDRLRPGDLVVYFPKATHVALYIGDGKVIQAPRPGAKVKVSPIAANPLLGAVRPDPEGTPLAEFTPPPLPEADPGTAGDDTGYDADEEPAAASAASPASATSTASAASATSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J212</accession>
    <name>A0A0F4J212_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000885">
        <property type="protein sequence ID" value="KJY26926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000885.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26926">
        <property type="protein sequence ID" value="KJY26926"/>
        <property type="gene ID" value="VR44_28845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2109"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21628" checksum="F1EF03074FB49F0E" modified="2015-06-24" version="1">MTLTFTTLGPEGSCHENALQHYFGFQGIEGDAKIDLTIDLHEGLERVRRGESDYLVQCSAHPEVHLLTERYFTEVHVVDTFVYPTKELVLLSRADVERPRSLGLVPATAGYVDVSQWEEVVPVASKPVVGAQLLAGAYDSGLTHLEYLEKSNGALRLDRYIGAVTTTWVVYGRRPRFSGEVIGTKCREYLLGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J313</accession>
    <name>A0A0F4J313_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949787.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28737">
        <property type="protein sequence ID" value="KJY28737"/>
        <property type="gene ID" value="VR44_24685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.934"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18602" checksum="2DC799B26F86F401" modified="2015-06-24" version="1">MVVAVVGVAGTLGASLLTQRGAERAKRREIELVREHEEVRENLALRRTCYAALNRDSRQYTTALNRHLHVMREQGVQDADREALDAAKAAHRDTYSEAQMIAPDAVLAAATAVNHALTLVYGQVKRLERGAPEAGETMETVSRAQQAIWDLLREMRAAMRVDLGVSAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3D9</accession>
    <name>A0A0F4J3D9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA ligase</fullName>
            <ecNumber evidence="9">6.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_24635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949775.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2992"/>
    <dbReference type="EnsemblBacteria" id="KJY28775">
        <property type="protein sequence ID" value="KJY28775"/>
        <property type="gene ID" value="VR44_24635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.922"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIGANc" evidence="11">
        <location>
            <begin position="13"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY28775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="633" mass="70263" checksum="54591C458741EE09" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3F9</accession>
    <name>A0A0F4J3F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949753.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3017"/>
    <dbReference type="EnsemblBacteria" id="KJY28800">
        <property type="protein sequence ID" value="KJY28800"/>
        <property type="gene ID" value="VR44_24515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.898"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25742" checksum="9B985302575C47F9" modified="2015-06-24" version="1">MPDFDYSDLSAVFVNCTLKRSPETSNTEGLISKSRAVMESAGARTSLIRAVDHDIATGVWPDMTDHGWESDQWPVLYSQIMDADILVLCGPIWLGDNSSVMKQVIERLYACSSLLNDKGQYAYYGRVGGALITGNEDGVKHCAMNVLYSLQHLGYAVPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRNTTFMSWNLMHLAALLKRAGGVPAHGNQRSAWDAGCRFDFPNPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J405</accession>
    <name>A0A0F4J405_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000720">
        <property type="protein sequence ID" value="KJY28544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28544">
        <property type="protein sequence ID" value="KJY28544"/>
        <property type="gene ID" value="VR44_25095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1110"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15287" checksum="F779CB8EDE3034FC" modified="2015-06-24" version="1">MGSQYGSDHAGFGCAACCAEDALVAQAHHQSHNGVRVERMIQDDSHFIVSVQRCGLCSQAFASVFTEYVDWVASQDAQYRTVLPITDAEADDLMAGRLSPHRVGALGHGRRHLQSDWPSEADKPSVYWDSGVFEVREGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J560</accession>
    <name>A0A0F4J560_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949686.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5565"/>
    <dbReference type="MEROPS" id="M14.007"/>
    <dbReference type="EnsemblBacteria" id="KJY28913">
        <property type="protein sequence ID" value="KJY28913"/>
        <property type="gene ID" value="VR44_24160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.784"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470129" evidence="1">
        <location>
            <begin position="32"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="48546" checksum="5533A496E65584DD" modified="2015-06-24" version="1">MRLHTRRRAAVTAALLALALGAPAYGMSATAAPPPTPSTATQDESVVQYEIQGPSTAVERTSLLSSGVSIDEVDARSVVVSATPAQAKALRARGYKLTALAGPPDRSERGVANRPMDFPSADSKYHNYAEASAEIDQRIAQYPGIMSKRVIGKSYQGRDIVAIKISDNVGTDENEPEVLFTAHQHAREHLTVEMALYLLQEFGSKYGSDSRITNMVNNREIWIVPDLNPDGGEYDIATGSYRSWRKNRQPNSGSTAVGTDLNRNWDYKWGCCGGSSSSKSSETYRGPSAASAPEVKVVSDFVRSRIVGGKQQIKAAIDFHTYSELVLWPFGWTYNDTAPGLTADDLAVYKKIGTSMAASNGYTPEQSSDLYITDGTIDDWLWGDQKIFAYTFEMYPSDTGGGGGFYPPDEVIDRETARNKDAVLQLLENADCMYRSIGKEAQYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5P0</accession>
    <name>A0A0F4J5P0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_22335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000625">
        <property type="protein sequence ID" value="KJY29677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949352.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000625.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29677">
        <property type="protein sequence ID" value="KJY29677"/>
        <property type="gene ID" value="VR44_22335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.354"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="78"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY29677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="498" mass="53963" checksum="89BA52D085B0638A" modified="2015-06-24" version="1">MPTATQTAPAPAAPAPAGRRRLPVPDWLWAALLTLAVTVFRAGTPQLWRDELASWEAASRGTGELIGMLGHVDAVSGLYYLLLHCWVSVFGDSAAMLRLPSGLAMAGAAALVVLIARALFDRRTAVFAGLLFALLPAVTRYGTEARSYAFVVLAVTAATWLLLRALERPSAWRWAGYSALVAVSGLLHMVSLLVLLPHAMIVVLRWWRGRRSRTVVSFAVAAVAGLVPVVPLVLLGRRQVGRQISWIDTPRMRDISGLWDNLFASPLVGLGIAALALLPLAWPRGRRPAVEVMLLGAVPIGACFVASQGSSSYFIDRYVLFTVPAWAILAAAGLAALRPRAAGAAGLAALVLLGAPDQRQLRTEQAKETSDGIAAARVIAKGYRPGDGFVPPRGKLERVFMIDYQIAYYLPDRVRLRDVFAERSAVASEDLFPVECKQPESCLGDTKRIWLVTRDTGDNHDPYNRLPAAPKKALKDHYRVASTTEVRGLHVSLLERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5S7</accession>
    <name>A0A0F4J5S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000746">
        <property type="protein sequence ID" value="KJY28276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000746.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28276">
        <property type="protein sequence ID" value="KJY28276"/>
        <property type="gene ID" value="VR44_25735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1252"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="14835" checksum="7A40EAE9EA573D68" modified="2015-06-24" version="1">MATQTKTGSLSDLDWLLGGLVQRVPYTRAAVLLTNDGLVTCVHGLDSDSADHMAALASGLYSLGRSAGARFGDGAEVRQVVVELDTALVFVSAAGSGTCLAVLADREADAGVLGYEMAMLVKSVRPYLAAPPRRPVADTDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J662</accession>
    <name>A0A0F4J662_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_22350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000625">
        <property type="protein sequence ID" value="KJY29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29680">
        <property type="protein sequence ID" value="KJY29680"/>
        <property type="gene ID" value="VR44_22350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.358"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="126"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="421"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="552" mass="59011" checksum="2943CA92517D0B0F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6F5</accession>
    <name>A0A0F4J6F5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000725">
        <property type="protein sequence ID" value="KJY28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28491">
        <property type="protein sequence ID" value="KJY28491"/>
        <property type="gene ID" value="VR44_25215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20009" checksum="F42B9A7C56571350" modified="2015-06-24" version="1" fragment="single">GKLPLAEPFRETGMFQPAALSEPLARQVLALTGAALRALGVTDGVTHTEIKLTPDGPRLIEVNGRMGGYVGALLRRSTRFDLLRAALRAALGLPLEVPELEFPAVEFVYFLTPPADAGATLAGIRGLEEVAAMEEVWQVKAEAVTGRSVHWRAGTEGHLGTVHGTAADHGRLRSAVRAIDAAIRLDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Z2</accession>
    <name>A0A0F4J6Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949199.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29955">
        <property type="protein sequence ID" value="KJY29955"/>
        <property type="gene ID" value="VR44_21530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.184"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046218">
        <property type="entry name" value="DUF6251"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19764">
        <property type="entry name" value="DUF6251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13129" checksum="46B71A205DDA00E3" modified="2015-06-24" version="1">MHQLPEHRPGAVVHLPDGTPVYADQLPATFAGPQVVHQHIHQAPPDRTVQRIALGSGVGAGAVAAGVYFGPLLIGALTAIAANLAFLAFLALVLGWGVHTVVKSVGGPEGTQAAKNVRKATARRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7C0</accession>
    <name>A0A0F4J7C0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_21340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949160.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5726"/>
    <dbReference type="EnsemblBacteria" id="KJY30070">
        <property type="protein sequence ID" value="KJY30070"/>
        <property type="gene ID" value="VR44_21340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8993"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="49"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="330"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="665"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY30070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="748" mass="81011" checksum="B2EBD89525C55D18" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7F1</accession>
    <name>A0A0F4J7F1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949710.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28881">
        <property type="protein sequence ID" value="KJY28881"/>
        <property type="gene ID" value="VR44_24285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="11260" checksum="9D8A377D4FF28F71" modified="2015-06-24" version="1">MSSSGDHISVDFATLQSAAGDLEEILKTLNEQLDLLYQRVEKAVLGWEGEARQTFVDQLDKWDRSAQDLQATQAWLHETVVHGHLTYASAHRAVLRGWGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7G2</accession>
    <name>A0A0F4J7G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000624">
        <property type="protein sequence ID" value="KJY29688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949347.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000624.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29688">
        <property type="protein sequence ID" value="KJY29688"/>
        <property type="gene ID" value="VR44_22320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.351"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="87"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35825" checksum="58D4B6D792884532" modified="2015-06-24" version="1" fragment="single">PAGPAPDWRKRIKIGSIAIVSVLLVTGIGTYFWADSQVRREVDLSKVIERPKEGDCTTYLIVGSDSREGMSDEEKKKLHTGSAEGKRTDSMMVLAKCSSGNTMVSLPRDSDVEIPSFVGSQSGKKYAGTGKRTKLNAAYADDGPELLVRTVEFNTGLRIDHYAEIGFAGFANIVDALGGVELDIEQGFKDEKSGADFKAGKQTLNGEQSLAFVRTRYAFAESDLQRTKNQQKFLSALASQAATPGTILNPFSLYPVMGAGLDTLIVDKDMSLWDMGEMFFAMKGISSGEGVSMNMPISGQRGGNLVWDKAKVQQLVKEIQNDQKVTVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7T2</accession>
    <name>A0A0F4J7T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949262.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29859">
        <property type="protein sequence ID" value="KJY29859"/>
        <property type="gene ID" value="VR44_21855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.250"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470808" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10538" checksum="667C90F1EF142A4B" modified="2015-06-24" version="1">MMVRTARRAGKALGACAAAALLALATPAGTAQAAEGVLELDGTEHEDPSGCYRLGDFAPPKVANHTDGTAWVWSGPDCDGQVTQQIDPGQTAIARGRSLYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8T6</accession>
    <name>A0A0F4J8T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3239"/>
    <dbReference type="EnsemblBacteria" id="KJY30797">
        <property type="protein sequence ID" value="KJY30797"/>
        <property type="gene ID" value="VR44_19435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8496"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="31582" checksum="3FCF38A22FF25B54" modified="2015-06-24" version="1">MGNEETVPLAHRVPDLGALELLLTVARVGSLSGAARRLGITQPAASSRIRAMETRLGVALVDRSPRGSTLTAEGALVTDWARRVVEAAEAFDAGAQALRGRRDSRLRVAASMTIAEYLLPGWLIALRGERPGTAVSLHAGNSADVAQRVLAHEADLGFVEGLTVPDGLDSAVIAQDRLVVAVAPTHPWARRSKGVEPAELAAAPLILRERGSGTRQVLDAALAGSGGLAQPLLELASTTAVKAAALSGAGPCVLSELALVEELAARRLVSVPVPGAALARALRAVWPTGTRPAGPARDLLSLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J940</accession>
    <name>A0A0F4J940_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_22920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949459.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29461">
        <property type="protein sequence ID" value="KJY29461"/>
        <property type="gene ID" value="VR44_22920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY29461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="587" mass="61998" checksum="58F9A8668A7ED6ED" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA06</accession>
    <name>A0A0F4JA06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948905.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000550.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30639">
        <property type="protein sequence ID" value="KJY30639"/>
        <property type="gene ID" value="VR44_19935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8607"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="461" mass="50324" checksum="A28B1BC3EC6C773E" modified="2015-06-24" version="1">MATVTAAPGPSFRGRLVRPGDPTYDEDRRVWNGSVDRHPALVACCAGVADVKDAVRFAAGEGLPLAVRSGGHSFPGHSVCDDGIVLDLSAMRGIRVDPEARTVRAQAGVRLGELDRETQAFGLAVPAGIVTTTGLAGLTLGGGIGWLMRKYGLTIDQLLSVDVVTADGSFLTADEERNSELFWGIRGGGGNFGIVTEFEFRLNPVGPVVLAGPVLWPMEESARLLRLYRDWITDVPDELTTAVVHRRVPPVPFMPQELHGRPVVMVVCCYAGPVEDGEKVLRPLREAGPPPLLDLCTPKPFTAHQAMFDPSFPRGRWYYFKSCDVDRLEDEVIDITAEHAARITSPLTAFPIFQLGGAIRRVGDEETAFGGRSGGHTFNINGTTEGPEGFQAEREWARGLWSALAPYQTGVYSNFLMEEGEERVAQAYGEAKYRRLRELKRHYDPDNLFRLNQNIPPAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAA6</accession>
    <name>A0A0F4JAA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE_Tnp_Tn3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_19585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000542">
        <property type="protein sequence ID" value="KJY30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948842.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000542.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30734">
        <property type="protein sequence ID" value="KJY30734"/>
        <property type="gene ID" value="VR44_19585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8528"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="7">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23658" checksum="191771F9C5FEFE37" modified="2015-06-24" version="1">METRADLPDGEEPAAGYGPLEAVACNKVNLKRIATHWSDMLRAAGSLITNQVQAYDLLRMFGREGHPTPLGAAFAEYGRIDKTMHLLALADPVDDTYRRRMSRQLTVQESRHRLARAICHGGRGQIRQAYREGQEDQLAALGLVLNAVVLGDTRCLDAXGVDIKEEDAARLSPLKGRHINFLGRYLFTIKASGPGQGLRPLRDPDAAHEDVPEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB82</accession>
    <name>A0A0F4JB82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948730.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31059">
        <property type="protein sequence ID" value="KJY31059"/>
        <property type="gene ID" value="VR44_18980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8400"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="18184" checksum="40279AE17BEACDD8" modified="2015-06-24" version="1">MDKREGREAGTVRLNDPWYDALATGWGEGAEAFPPRRPPADRGDDLRASDIYLEVQRSAAFQEVRGRYRRFVVPATAGFLLWYVAYVVAATTAPGLMARPVVGSVNVALLAGLGQFLSTFLLTWAYSRHARLRRDGAALDLRWTVFERERGQERGRGGRGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBK3</accession>
    <name>A0A0F4JBK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000516">
        <property type="protein sequence ID" value="KJY31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948708.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000516.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4111"/>
    <dbReference type="EnsemblBacteria" id="KJY31118">
        <property type="protein sequence ID" value="KJY31118"/>
        <property type="gene ID" value="VR44_18865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="47175" checksum="5798D0661DA0E028" modified="2015-06-24" version="1" fragment="single">MTATSGTAAESGRTAWRNWAGNVRATPARVVTPASVGELQEAVRRAAAEGLRVKAVGTGHSFTAAAATDGVLVRPQALSGILSVDRAAGTVTVAAGTALKDLNRALAAQGLSLTNMGDIMEQTVSGATSTGTHGTGRDSASIAAQIRGLELVTADGRLLVCSEKENPEVFAAARLGIGALGVVTSITFAVEPLFLLTAREEPMRFDRVTAEFDQHVAENEHFEFYWFPHTGNCNTKRNNRSQGPAAPPGAVSGWIEDELLSNGLFQAVNSLGRAVPAAIPSIARIASRALSARTYTDIPYKVFTSPRRVRFVEMEYALPRERAVEALRELKAMVDRSGLRISFPVEVRTAPADDIPLSTASGRETAYIAVHMYRGTPYQAYFTAAERIFTAHGGRPHWGKVHTRDAEYLAAAYPRFGEFTALRDRLDPDRVFGNDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBP3</accession>
    <name>A0A0F4JBP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000509">
        <property type="protein sequence ID" value="KJY31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948655.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000509.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31224">
        <property type="protein sequence ID" value="KJY31224"/>
        <property type="gene ID" value="VR44_18585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8313"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024067">
        <property type="entry name" value="Me-malonyl-CoA_mutase_sm_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="623" mass="64506" checksum="C55CB6D526B52DF6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCF9</accession>
    <name>A0A0F4JCF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000548">
        <property type="protein sequence ID" value="KJY30666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948896.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000548.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30666">
        <property type="protein sequence ID" value="KJY30666"/>
        <property type="gene ID" value="VR44_19890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8597"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20560" checksum="FB3C6E7D4FF59DA1" modified="2015-06-24" version="1">MLVALIIACEVGFWVLLAGGLALRYLAGMPRLGAALLLCEPLLELVLLAVGVVDLKNGGEPSWRHGVAAFYIGYTVGYGHYTVKWLDRHAAHRLAGGPKPPGPKYGRARAVHEWKLWVRTLAGAAVAVVLLQGAIWYVGDAADTGGLRSWQFAALRVLGIQALIAATYSLWPRRAPAGTDADKESDLAGKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCV4</accession>
    <name>A0A0F4JCV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948329.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32025">
        <property type="protein sequence ID" value="KJY32025"/>
        <property type="gene ID" value="VR44_16860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7807"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7840" checksum="A6E915370581B257" modified="2015-06-24" version="1">MDGRQDKRKEPGKGSEAQEHRRPGDPAQPQPGRSSREKGEAGHKPGQKETSRRREDDLLREEDLHDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDG8</accession>
    <name>A0A0F4JDG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_16300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000425">
        <property type="protein sequence ID" value="KJY32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948225.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32250">
        <property type="protein sequence ID" value="KJY32250"/>
        <property type="gene ID" value="VR44_16300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7714"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="148"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="30984" checksum="7E3CAB205E5576B2" modified="2015-06-24" version="1">MLALAVTVAIWAAFALSARALSASTLLPADAALLRFGVPVLVLAHALWRRRRRIAAVRPGAALKIVCGAGVPFFLAAMHGGSLTSAAFVGSIVPGMVPLFVSALMAARGRGLPRGAQVAGLALIAAGVAALVWRYVVPVDAAVLEGAGTLLVASGLWALYTVGLRDVDLDPVGSIGLLCLPSFAVIGLLVLTGVLPTGLAHAAGGDIALFLVVQGLGVGLCAGLLYAFAIRRLGAERSSVVGSLSPVAVVLLAIPVLGESPTAAVLVGVPLITAGVVLANRRPGPRTRTRGRTPSSVRPRPEVPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE44</accession>
    <name>A0A0F4JE44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000403">
        <property type="protein sequence ID" value="KJY32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948098.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000403.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32622">
        <property type="protein sequence ID" value="KJY32622"/>
        <property type="gene ID" value="VR44_15640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7529"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22516" checksum="34083E052DEF3891" modified="2015-06-24" version="1">MTSHIPPQLTVGFDLDMTLIDSRPGIHAAWTALSAKTGTFIDADLAVTRLGPPLEEELAYWFPEDRIPAMRDLYREMYPSYAIEPTPAMAGAREAVKAVQALGGRAIVVTAKNEPNARQHLDHLGIDADAVIGWLWAEGKAKALREYGAQVYVGDHIGDVRGARTAGALSVAVATGPCGAEELREAGADVVLDDLTALPEWLAGFARTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF16</accession>
    <name>A0A0F4JF16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948516.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000483.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31561">
        <property type="protein sequence ID" value="KJY31561"/>
        <property type="gene ID" value="VR44_17890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8121"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471001" evidence="2">
        <location>
            <begin position="33"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="23752" checksum="662700F63879F874" modified="2015-06-24" version="1">MRTRTTTAGLAATLAALLALSGCTSSDGGPHAATGTPAAAPAPVQGGGSGYEGPRPQDQNLLAWTGDPNDAGHVTAQSAAGVGGRITLVRIGLREQITWSNIWLGLAGVDANAQLSNCYLGVYDATGKLVASTADISPQLMTDAVAKPLPLTKPFTAGTGTYFIALLLNGNWATNALTLKATGAGISVNAGLTPPALRYSTVLTGQTSLPATLNLAEQSTSTINTGWGSQWYGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFG3</accession>
    <name>A0A0F4JFG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000472">
        <property type="protein sequence ID" value="KJY31731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000472.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31731">
        <property type="protein sequence ID" value="KJY31731"/>
        <property type="gene ID" value="VR44_17610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8087"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="33282" checksum="D130922977B528AF" modified="2015-06-24" version="1">MTTAVFQPATADTYAHQVLALIAQHRLLTSTQLHQMLMPNTPPRKIHNVLVPLREQGLIAHTVLPGRLQAHFLTPAGHQTVGDWPELRGRTANPIQSSSAASLRAAHILTGVRAHLAFLTDARARGDEYQPLDWVPEVTHRLPDTAGEDRLVADAVFHYTATNPRRLQYRAFVEIDRTTMSSERLARKLITYARFHDYTPQPVGRRGTVADQGTVLAWQRSYPRFPRVLFILTGASRTTLANRIADLRRMTADHDLVTRLSAHVPLGAAVLEDIEAHGPQAKVWTPLAGSSEPRGWAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGB2</accession>
    <name>A0A0F4JGB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000390">
        <property type="protein sequence ID" value="KJY32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948015.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000390.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32849">
        <property type="protein sequence ID" value="KJY32849"/>
        <property type="gene ID" value="VR44_15190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7375"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20286" checksum="87C4DC746CB45775" modified="2015-06-24" version="1" fragment="single">LGPRIDFRFATDVLDPSTDFPENAFEYVVLAHCSWYFASFGQLRDTLARVRPWARRLCFAEWDLTPSSDDQLAHLLAVLIQGQAEAAGSHGPGNVRTPFSREELLRLLPRAGWTADGSRPVDTEGLQDGDWEIEACLDLVGTRERLAALPEPVRTLVLSQADVLRATAAPRGNRALAAYAVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH35</accession>
    <name>A0A0F4JH35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_14590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947905.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33063">
        <property type="protein sequence ID" value="KJY33063"/>
        <property type="gene ID" value="VR44_14590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7244"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15257" checksum="2E5731DA3D0CA39A" modified="2015-06-24" version="1">MTVRVVVGGALCRDGRLLAARRSAPPELAGRWELPGGKAEPGETVPEALVRELREELGVETEALERIPGEWPLKPGLVLHVWTARLLSGEPAPLEDHDELRWLAPHELDSVDWLDQDRPFVAEAGRRLACQGAGGAHRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHE7</accession>
    <name>A0A0F4JHE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_14415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947877.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33178">
        <property type="protein sequence ID" value="KJY33178"/>
        <property type="gene ID" value="VR44_14415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7232"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="734" mass="77913" checksum="011C9A43D610180C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHT7</accession>
    <name>A0A0F4JHT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_14155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000364">
        <property type="protein sequence ID" value="KJY33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33328">
        <property type="protein sequence ID" value="KJY33328"/>
        <property type="gene ID" value="VR44_14155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7177"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="7">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13665" checksum="B854DEAB25550DB9" modified="2015-06-24" version="1" fragment="single">LELGLDGIIATNTTIAREGLGLKSDPALVKETGGLSGAPVKERSLEVLRRLYARVGDRITLIGVGGIENAEDAWQRILAGATLIQGYSAFIYEGPFYARAIHKGLAARLAASPYATLAEAVGAETRKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIR2</accession>
    <name>A0A0F4JIR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34237">
        <property type="protein sequence ID" value="KJY34237"/>
        <property type="gene ID" value="VR44_12280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="15742" checksum="FEEDF8B5BAAB6A1A" modified="2015-06-24" version="1" fragment="single">MPGETMPGEGKSGEGRSGAGGVDPERLWLRPAEPRRGRRPSFTREAITVAAVAVADAEGLEAVTMRRVAAEVGAGVMSLYSYAPDKETLLELMVDHVSAELAVPAPPTGDWRAGLKAVARLQRAHMLRHPWLPAALSTRRSPGPNTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJK0</accession>
    <name>A0A0F4JJK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,4-alpha-glucan branching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947376.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34507">
        <property type="protein sequence ID" value="KJY34507"/>
        <property type="gene ID" value="VR44_11700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6306"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="22406" checksum="2859EF9EBEF7EFDB" modified="2015-06-24" version="1">MAVIHRTTMKPGKLELLAGWLPARPWYAGASAAPDLARAGGFRIDDPEGEVGIEFMVVTDSSGAGPVAYLVPLTYRGAPLEGAEEGLIGTSEHGVLGTRWIYDGAHDPVLTGRLLALLRGEAAPQHQSETGVPDPTVVPETAEDALPGGAAVVGVEDGPEGTRLVVEAGGRRLGLELLRVLEAGRTVPGALGRVTAGWELPDGTRPRGAFAVLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJQ1</accession>
    <name>A0A0F4JJQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947574.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000318.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene508"/>
    <dbReference type="EnsemblBacteria" id="KJY34039">
        <property type="protein sequence ID" value="KJY34039"/>
        <property type="gene ID" value="VR44_12760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6633"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="461" mass="50127" checksum="A3A0BA609DE3B5DB" modified="2015-06-24" version="1">MSTTERPRILVVGGGYVGLYAAKRIMKKMRYGEATVTVVDPRSYMTYQPFLPEVAAGSISPRHVVVPLRRVLPKAEVLTGRVTTIDQDRKVAVVTPLVGEAYELPFDYLVIALGAVSRTFPIPGLAEQGIGMKGVEEGIGLRNHVLEQLDKAESTTDENVRRKALTFVFVGGGFAGAETIGEVEDMARDAAKYYSTIKREDMRFILVDAADKILPEVGPKLGTWGKEHLESRGIEIYLNTSMDSCVDGHVVLKNGLEVDSNTIVWTAGVKPNPALARYGLPLGPRGHVDTAPTLQVQGTDYIWAAGDNAQVPDVASRKAGVENAWCPPNAQHALRQAKVLGDNVVSGMRGFPQKEYEHSNKGAVAGLGLHKGVAMIVMGKMKIKLKGRLAWYMHRGYHGMAMPTWNRKIRVFADWTLGMFLKREVVALGALETPREEFYEAAKPAPAPAAAAAPAQKAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK11</accession>
    <name>A0A0F4JK11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947551.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34103">
        <property type="protein sequence ID" value="KJY34103"/>
        <property type="gene ID" value="VR44_12635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17399" checksum="DEC458D19A67584B" modified="2015-06-24" version="1" fragment="single">MTGRKTAAEVFDALAGRYEEAFGAVPAQREALDWLAARLPRGARVLDVGSGTGRPTAETLARAGCEVTGIDVSPEMVALARTRVPGARFEQADVRTWTPPGPGGFDAVCAFFPLLMMDQREVGACLERMASWTVPGGYLVVATVPGDIDALDIEFMGHEVTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKJ7</accession>
    <name>A0A0F4JKJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase / thiol specific antioxidant / Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_13885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947784.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000355.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33466">
        <property type="protein sequence ID" value="KJY33466"/>
        <property type="gene ID" value="VR44_13885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7062"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="611" mass="65599" checksum="A6F7E98D495FB85E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLP9</accession>
    <name>A0A0F4JLP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_11450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34744">
        <property type="protein sequence ID" value="KJY34744"/>
        <property type="gene ID" value="VR44_11450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6188"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="483" mass="49845" checksum="616FEC6D9BA82E9C" modified="2015-06-24" version="1">MPFPSAFTVLVAVTVAVWALTFAISAGRYDTTPDGAPIPGTYHAVERTTDFLDRLKDLFLSPVNGLYGVTDAGTGLTTPGAAGSFAGAAGVFLFILAVGAFITVTLRTGALDLGVARLAHRLHGHRTLLLVALVAVFSLGGTTYGMAEETLGFYGLMIPLMLALGYDRMVAASVIMVGAGVGTLASTVNPFATGVASDSAGIGTGDGILLRLAMWVSLTAIAAWYVLRYAKRVLADPARSLTPSTDEDRALAEQDEEVAALTGRHRAVLGVFATTFLFMIFAVVPWADLGVTFLPTLGWYFPELAALFIVAAVAVGLIGGLGEHGTAEAITRGAGDFVGAGLIVVLARGVTVIMNNAAVTDTILNGLHSAVSGTSHGAFAVLMFLVNVPLAFLVPSSSGHAALAMPILAPLADFAGVRRSLVVTAYQSASGWVNLITPTSAVVMGGLALAKIRYDQYLRFVAPLMGILLLAIGGFMVLGATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMJ8</accession>
    <name>A0A0F4JMJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34176">
        <property type="protein sequence ID" value="KJY34176"/>
        <property type="gene ID" value="VR44_12485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6557"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="20581" checksum="1825FD740B93F4F4" modified="2015-06-24" version="1">MSTSTLIAVVVAAVVVVLAITVTLVLLARRRHLRHRFGPEYERAVEEKGGVLAAERDLHAREVRHDKLDIRELPPERRRQFADRWSEVQEHFVDQPAGSVDEADDLVAKLMRERGYPTDGYHGAVRDLSVEHGRTLEHYRAAHDIRSRSTGGRATTEELRAAMVHYRALFDELLTDQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN40</accession>
    <name>A0A0F4JN40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP nucleotide 3'-pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947166.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35244">
        <property type="protein sequence ID" value="KJY35244"/>
        <property type="gene ID" value="VR44_10555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5855"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470685" evidence="2">
        <location>
            <begin position="35"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="26870" checksum="D8AF094D5E3D27B3" modified="2015-06-24" version="1">MTTSTTTAPAISRILSAAALATALALGSGTGAVAAGPAGDGWKGEGGLTLNAADNASVDAYVERAKDAEEAISTDVRAAALVTGAELVGFEYRLKSADSLKRKVATSLRERPGQNVDTVLAGLGDAVRYTLQWPDDAYSDGVTTASALLSAWGNDNTKWSNTWGRSSGYKGLNTGWRAPRSGQLFEVQFHTPASKHAQEVTHLLYEEQRLPSTSPARKKELQALQDAEFAAVPVPAGADRLSPPARTGVPLPVPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JND2</accession>
    <name>A0A0F4JND2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946938.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35705">
        <property type="protein sequence ID" value="KJY35705"/>
        <property type="gene ID" value="VR44_09335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5195"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="7086" checksum="BB6D55479E514EA1" modified="2015-06-24" version="1">MADITWEDPYCAEGASCYRLGVDQDGNSYIAVAGREDTPLVDTREALSALIRDIKAGKADHLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNH0</accession>
    <name>A0A0F4JNH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000202">
        <property type="protein sequence ID" value="KJY35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946930.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000202.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35745">
        <property type="protein sequence ID" value="KJY35745"/>
        <property type="gene ID" value="VR44_09295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5186"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045629">
        <property type="entry name" value="DUF6232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19744">
        <property type="entry name" value="DUF6232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="16616" checksum="CE5975ABB7E333F9" modified="2015-06-24" version="1">MLWVGSAAIPLHNITWVDAFKHRRSRWGVFGRTLLGLTAAFVLLAAYGAGGDLSVLADDGQGVRVIVPAILVISLLVALFTPGKPVLAIEMAGGSRAVVTLPNMEELRQIAGQVVYAINHPDAEFTAVVNQFNSSNTNHFGPVVNMNGGRGNTGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP02</accession>
    <name>A0A0F4JP02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946803.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene955"/>
    <dbReference type="EnsemblBacteria" id="KJY36097">
        <property type="protein sequence ID" value="KJY36097"/>
        <property type="gene ID" value="VR44_08610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4864"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="36056" checksum="F67EB0BA7B095C45" modified="2015-06-24" version="1">MTVVGPFGLSVRDQALEADVQAGLAAVEAGLLEATKSEVPFITEAAQHLVRAGGKRFRPLLVMLAAQFGDPYAPGIVPSAVVVELTHLATLYHDDVMDEADVRRGVESANARWGNSVAVLTGDFLFARASHILADLGPEAVRIQAEAFERLVTGQILETAGPRDGRDPVAHYLDVIAGKTGSLIAVSGRFGALMSGADESVVDILTQYGERLGTAFQLADDVLDIASDSHESGKTPGTDLREGIPTLPVLRLREMAERDGREEDQELVRLLEGDLTDDARHAEVLSRLRVHPALEQARRDTVQYAQDARAMLAPLPDCFAKAALEELCDAVVHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP53</accession>
    <name>A0A0F4JP53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon proteolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000215">
        <property type="protein sequence ID" value="KJY35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947058.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000215.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35528">
        <property type="protein sequence ID" value="KJY35528"/>
        <property type="gene ID" value="VR44_09975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470748" description="Lon proteolytic domain-containing protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="157"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27126" checksum="9E99CAABC3B149A1" modified="2015-06-24" version="1">MLSRLTRLPRPTALAVCAAPVLALFAVAALAPLPFVVAVPGPTADVLGSDQGKPVITVTGAPVRDTKGQLRMTTIRATGPSSSMKLHELVDHWFRSDQAVMPREAVYPTGGSDKEIEQHNLEEMSQSQSAAEAAALGYLHKDPKSVKVDLNLADVGGPSAGLLFTLGIVDKIDGDGSGGDLTGGRSIAGTGTISADGTVGAVGGVGLKTQAARRDGATVFLVPKAECSDAKSELPEGLQLIPVTSLTDAVDALRALNRGEGVPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPB5</accession>
    <name>A0A0F4JPB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000212">
        <property type="protein sequence ID" value="KJY35593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947032.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3695"/>
    <dbReference type="EnsemblBacteria" id="KJY35593">
        <property type="protein sequence ID" value="KJY35593"/>
        <property type="gene ID" value="VR44_09820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5464"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="345" mass="36395" checksum="A00DF130CFBCEB5C" modified="2015-06-24" version="1">MSAAAPPADERLAPVSYVRRLLGRPELGAVVGAAAVFVFFSFAADSFLKASSLSTVLYSASTIGIMAVPVALLMIGGEFDLSAGVMVTTSALFSSMFSYQMTANVWVGVGVSLLVTLAIGFFNGFMLTRTKLPSFIITLGTFLMLTGLNLGFTKLISGTVSTKSIADMEGFSSARALFASQWNVGSVTLKVTILWWLALVAVATWILLRTRAGNWIFAVGGGADAARATGVPVVKTRIGLYMGVALCAWISGQHILFSFDVVQSGEGVGNEFLYIIAAVIGGCLMTGGYGSAIGSAVGAFIFGMASNGIVYAQWNPDWFKFFLGAMLLLATLLNAWVRKRAEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPM3</accession>
    <name>A0A0F4JPM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="12" type="ORF">VR44_09240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946918.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5097"/>
    <dbReference type="EnsemblBacteria" id="KJY35794">
        <property type="protein sequence ID" value="KJY35794"/>
        <property type="gene ID" value="VR44_09240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5112"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY35794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="36997" checksum="CAEEBF49E2E5AB2D" modified="2015-06-24" version="1">MTTLNLDDFSDLIERPDGGVRRDAEERRGRLALPPGALGRLDELAEWLAAAQGRVPVRPIERPRVVLFAADHGIASGGVSARPAGSAHELVRAVLDGTSPVSILAERFGAGVRVVDAGLDCDPGLLPEEVVRHRVRRGSGRIDVEDALTAEEAEAALKLGIRIADEEADSGTDLVVLGDLSVGGTTVAATLVAALCGTDASVVTGRGGLPIDDLAWMRKCAAIRDSLRRARPVLGDQTALLAAVGGADVAAITGFLLQCAVRRTPVILDGIVSAACGLVAQRAAFRAPDWWLAGQSSGEPGQAKALDRMALNPVLDHGVTVGEGTGALLALPLVQAAAALAAELPETSSGEGPTDQKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQX9</accession>
    <name>A0A0F4JQX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946631.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36585">
        <property type="protein sequence ID" value="KJY36585"/>
        <property type="gene ID" value="VR44_07695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36568" checksum="F5CBA5FF66E0F465" modified="2015-06-24" version="1">MPGAIYAEALVKTFGDVRALDGVDLDVPEGTVLGLLGPNGAGKTTTVRVLTTLLRPDSGRAVVAGIDVLKHPNQVRHSIGLSGQFAAVDEYLTGRENLRMVGQLYQMSGRAARARADELLERFNLAEAADRTAKTYSGGMRRRLDLAAALVVRPPVMFMDEPTTGLDPRNRQALWDVIEELVAGGTTLLLTTQYLEEADRLAHDICVVDHGRVIARGTSDQLKARTGGERVEVVVHAREHITTAREVLTGLGRGETTVEEHTRKLTVPVQGGAKLLAEVIRELDLRGIEIDDIGLRRPTLDDVFISLTGHAAQLTGEGADGAGPPQAGGRGDALMEKEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS4</accession>
    <name>A0A0F4JRS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36529">
        <property type="protein sequence ID" value="KJY36529"/>
        <property type="gene ID" value="VR44_07880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4283"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9648" checksum="2800B2A3FBFBF91B" modified="2015-06-24" version="1">MGGVAGRPPGRVRAMAPMAVPPATAAARREPPPSAALVRRELPEEKWVRVVEFAGSLPRTRSGKVRGAGLKGRAPGTEFGMAPLRGPRVDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSF9</accession>
    <name>A0A0F4JSF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_07455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="KJY36693">
        <property type="protein sequence ID" value="KJY36693"/>
        <property type="gene ID" value="VR44_07455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3966"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="992" mass="106446" checksum="E7670614F91C517D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSN5</accession>
    <name>A0A0F4JSN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">VR44_06265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946367.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene74"/>
    <dbReference type="EnsemblBacteria" id="KJY37190">
        <property type="protein sequence ID" value="KJY37190"/>
        <property type="gene ID" value="VR44_06265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3007"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="46286" checksum="9B3757C5B09E9E0B" modified="2015-06-24" version="1">MTDIVDELKWRGLFAQSTDEEALRKAFADGPVTFYCGFDPTAASLHVGHLVQVLTVRRLQQAGHRPLALVGGATGQIGDPRPTAERTLNDPETVANWVTRLRTQIEPFLSFEGENAAVMVNNLDWTAGMSAIEFLRDIGKHFRVNKMLTKDSVAKRLESDQGISYTEFSYQLLQGMDFLELYRRYGCTLQQGGSDQWGNLTAGLDLIHRLEPQAQVHALATPLMVKADGTKFGKSESGAVWLDPEMTTPYAFYQFWLNVDDRDISTYMRILSFRSREELEELEAQTAERPQARAAQRALAEELTTLVHGADQCAAVIAASKALFGQGELAELDAATLAAALSELPHAQVAELGPVVDLFAETGLVASKSAARRTVKEGGAYVNNVKVTAEDAVPAQEDLLHGRWLVLRRGKKNLAAVEVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSP3</accession>
    <name>A0A0F4JSP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946520.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36854">
        <property type="protein sequence ID" value="KJY36854"/>
        <property type="gene ID" value="VR44_07095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3762"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11359" checksum="7D44443D6EF9A1F8" modified="2015-06-24" version="1">MAQRVVVTISDDLDGGEAAETVTFALDGKSYEIDLNVANAKKLRKSLEPFVAAGRRQSRSGKAFKHTAVAPDPAVVRAWARSNGHDVPPRGRIPKAVYTAYNEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSR4</accession>
    <name>A0A0F4JSR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946243.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37412">
        <property type="protein sequence ID" value="KJY37412"/>
        <property type="gene ID" value="VR44_05600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1933"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11677" checksum="8349D7ABE91AE429" modified="2015-06-24" version="1">MTVELRVAEGWLTVCELSSLVPGRGVAALLPDGSQAAVFVDRAGRPYAIGNQDPFTGAQVLSRGLVGWAAGRAFVASPLLKQRFDLESGRCLDDEEVAVRTYPVRTATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT04</accession>
    <name>A0A0F4JT04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_05965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946311.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2622"/>
    <dbReference type="EnsemblBacteria" id="KJY37315">
        <property type="protein sequence ID" value="KJY37315"/>
        <property type="gene ID" value="VR44_05965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2407"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="102"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="24066" checksum="7CB213E3C03F2742" modified="2015-06-24" version="1">MAIYTLPELPYDYAALEPVINPQIIELHHDKHHAAYVTGANTTLEQLAEAREKENWGALNGLEKNLAFHLSGHILHSIYWHNMASPKTGEGGGEPTAADGVGDLADAITESFGSFEKFKKQLTFASSATQGSGWGVLAYEPVSGRLVVEQVYDHQGNVGVASTPILVFDAWEHAFYLQYKNQKVDFIEAMWNVVNWQDVARRYADAKANTPLLIPVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTD0</accession>
    <name>A0A0F4JTD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946406.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37084">
        <property type="protein sequence ID" value="KJY37084"/>
        <property type="gene ID" value="VR44_06465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3205"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8355" checksum="C410C1F9803518C6" modified="2015-06-24" version="1">MSRPGRERQRQAVPGWVTEGTAIRDPLERKNGIVQFIGEWVDPATRITITNAIFARPPGGGKEWIVKDPSSLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTD9</accession>
    <name>A0A0F4JTD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">VR44_05645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946251.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2517"/>
    <dbReference type="EnsemblBacteria" id="KJY37420">
        <property type="protein sequence ID" value="KJY37420"/>
        <property type="gene ID" value="VR44_05645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1944"/>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="4"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="52524" checksum="BAB4132AF76F3DB1" modified="2015-06-24" version="1">MAADKIETLVSLSKRRGFVYPCSEIYGGSRAAWDYGPLGVELKENIKRQWWKAMVTGREDIVGIDSSVILAPEVWVASGHVATFSDPLTECTSCHKRHRADHLEEAYEAKHGRLPENGLADVNCPNCGVKGQFTEPKQFSGMLETHLGPTQDTGSKAYLRPETAQGIFTNFALVQTSSRKKPPFGIAQMGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEQWQEYWMQERWNWYRGLGMREENMRWYEHPKEKLSHYSKRTADIEYRFNFGGNEFSELEGVANRTDYDLKAHSAASGQDLVYFDQESKEKYTPYVIEPAAGVNRAMFAFMIDAYVEDEAPNAKGAMEKRTVMRFDPRLAPVKVAVLPLSRNAQLSPKAKGLAADLRKNWNIEFDDAGAIGRRYRRQDEIGTPFCVTVDFDTLEDNAVTVRERDTMKQERVSLDQIQAYLGSRLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUF9</accession>
    <name>A0A0F4JUF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methlyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000106">
        <property type="protein sequence ID" value="KJY37403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946265.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000106.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37403">
        <property type="protein sequence ID" value="KJY37403"/>
        <property type="gene ID" value="VR44_05715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1958"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24657" checksum="0F7AE94F4D11DF11" modified="2015-06-24" version="1">MPTPSHDHDHDHTHGDHDHGNGNGAGAAATGQEFWDSRYRESERIWSGRPNSVLVREAADLAPGRALDLGCGEGADAVWLAGRGWRVTGTDISPVALERAAGHAADAGMADRIAFERHDLGESFPAGEFDLVAACFLHSPGEMPRERILRTAAAAVAPGGVLLVAGHGGPAPGAENPHPDLYFPTPQEVLAGLELPEDGWEVLVCAEHERTGTEADRPGHGYDNTLKVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK5</accession>
    <name>A0A0F4JVK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946469.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2747"/>
    <dbReference type="EnsemblBacteria" id="KJY36981">
        <property type="protein sequence ID" value="KJY36981"/>
        <property type="gene ID" value="VR44_06805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3441"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29674" checksum="547D32806D32928F" modified="2015-06-24" version="1">MKARRAARGLSLHAVVWLIGAFVAAPLGYAVISGFKSTGELTTNPFGLPGRWEAGNYTGILGDGMFWRQIANSAGIAIGTTCCTVAASAMAAFVLARYAFRGRELFYALFTVGLMFPFAVAVLPLFLLLRTFGLLDNPLGVILPQAAFGLPTTIIILRGFFRTIPAEVEEAAVMDGCGKFRFFWRILLPMARPALGTVSVLAIVASWNNFFLPLLVFDSPTWQTVPVGVQQFQGQYSTDYALVLAYIVLAMVPALAFYAVAERQLIGGLTAGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVV9</accession>
    <name>A0A0F4JVV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37893">
        <property type="protein sequence ID" value="KJY37893"/>
        <property type="gene ID" value="VR44_04770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1034"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="22911" checksum="01E5CBD95668FDC7" modified="2015-06-24" version="1">MILPANLPERSWEQIGTNLRELGNSSAWWLADWLRFGEATYGWRRYKEAIERTGLDYQTLRNYAWVARRFDHHRRRDGLSFAHHAEVARLSPPEQDYWLRRAEQQKWSRNELRRSVRAGLAVQNDTAGLPAGGGDEQPAAAAAQRCPRVTKLTIELSADQLEHLSKAAAAHGLPVDKWVTRLLETADRTTADRTTAELKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW66</accession>
    <name>A0A0F4JW66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946067.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37968">
        <property type="protein sequence ID" value="KJY37968"/>
        <property type="gene ID" value="VR44_04575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.995"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="473" mass="50341" checksum="4E742D87FC874783" modified="2015-06-24" version="1">MNGPCTAPARTVRRRALVIGGGTAGMLAAAALRGAVDEVLVVEADELPDGPLPRKGLPQARHAHMLWSGGVRAAEAVLPGITARWLAAGANRIPTPTGMVALTSQGWLRRWDRETHFVLGCSRDLLDSVVRDHVLGAEGVTVLQRTRVEGLTGSASRVTGVRVRGADGRETVLEADFVVDASGRASRAQRHLESLGVRPAPERSLDLGLVYATRVFRAPEGAEGFPIVSVQSDPRSGRPGQSASILPVEGGRWIVTQTGTRAGAPTGDAEGFAAFPRGLRHPVVGEIISRLEPLTGVSLSRSTRNTRRYFERVRDWPERFVVLGDALAAFNPLYGHGMSVAAQTAAVLREEAGLRGVDAPGLARRVQRAMAKPVGAAWELAMGQDVFYPEVQGGAPGLRDRVLARYVDRLVRTSCGRFSMVEDLTDVTSLQAPLTSLVRPRVLLGAVRGPRYPPLSGPPLTARELALVGGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW83</accession>
    <name>A0A0F4JW83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene828"/>
    <dbReference type="EnsemblBacteria" id="KJY38099">
        <property type="protein sequence ID" value="KJY38099"/>
        <property type="gene ID" value="VR44_04160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.121"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="538" mass="57310" checksum="22B092DD56D96432" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW90</accession>
    <name>A0A0F4JW90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38109">
        <property type="protein sequence ID" value="KJY38109"/>
        <property type="gene ID" value="VR44_04215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.133"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="47300" checksum="F69F555E9EE5660B" modified="2015-06-24" version="1">MPGHPVHWLGGDSLSWPDRTAQRRIIGSLMFIGFLLTAGLLLRIGWMDSQRALTFGERLAGYSILAAGLVELIAAGATLDYWHQRKRSYSGPFVLAGVAIVFLCSSSLLFLQIGERFTGWTVIAISFLAGSIVAGIELIRSRAWKGLRNPRRIAIGAIVPTLIAGINLAYTQLYVPTVTAPLIMSGAEFREASLDSARSVLRVTVHAYVKNNGSVPVYILGSIYWVHGGPANDITQTRNPSFKLIYDGEFVTPAGRELDPGEEISQDSVVDIKDPDKLKYETLKAQTEVYAIRRDRMTLPAAYGQSRTFAKALENWKPKEPGKVEYIDGSRISNSSEIRNIAWGKQYIRTWKVSFGNWSRIDISISPPGNRITLDSRDAHFRQRLIDRYGLLLARGSMDQTPFKTLLEKAHSPEKGSGTDQSDQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX26</accession>
    <name>A0A0F4JX26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">VR44_03785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266795.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene782"/>
    <dbReference type="EnsemblBacteria" id="KJY38404">
        <property type="protein sequence ID" value="KJY38404"/>
        <property type="gene ID" value="VR44_03785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8660"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6694" checksum="A27A67C3C9EFEC89" modified="2015-06-24" version="1">MAANCDVCAKGPSFGNNISHSHRRTSRRWNPNIQRVRAVVNGTPKRLNACTSCIKAGKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXS9</accession>
    <name>A0A0F4JXS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38538">
        <property type="protein sequence ID" value="KJY38538"/>
        <property type="gene ID" value="VR44_03395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7896"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="10848" checksum="49335713712BE470" modified="2015-06-24" version="1">MTAEAALVIPALVLFAALLVWALMAAAAQIRCVDAARAGARAAARSEPVGAVLAAARQAAPPGAEVELERSGDLWRVRVAAPAPGPAGLPVRIGARAVALAEDSVGPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY12</accession>
    <name>A0A0F4JY12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946091.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37891">
        <property type="protein sequence ID" value="KJY37891"/>
        <property type="gene ID" value="VR44_04785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1037"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="37376" checksum="7D4B72E2B04E97E2" modified="2015-06-24" version="1">MQFRILGLVEVRDEEAGLHLLPTGAKQRALLGALVVRAGHHVSVRQLIDELWGEEPPANAENALQVHVARLRRLLSGTEDGRDGGREGGREAGRRAPQPWIVTTSRGYTLRLGPVETDAACFQQLTDTARRILHEDPGRAGELLRRALSLWRGPALEGSVLGDICAGRAAQLEEDRLTALEMMYDAYLRTGRHGEITGELMVLTTDHPMRERFYDLLMVAFYRCGRQAEALRVYERARHRMVHDLGVEPGPALRRLMQAILQHDPSLGPAACPLPAGPPRVPALPAVADTAAGDAVVPLMEEIVRLRGRIERLQQEQNQLMCRLEELTGGAPVRRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYF6</accession>
    <name>A0A0F4JYF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000052">
        <property type="protein sequence ID" value="KJY38773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38773">
        <property type="protein sequence ID" value="KJY38773"/>
        <property type="gene ID" value="VR44_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="15780" checksum="392298FEE9D87F9A" modified="2015-06-24" version="1" fragment="single">MAAAPGAPAQGPEPQPALAEVFADSLVVLTAPHEGRAGTRKRAASRRRRGRTALAVGLGLVLATGGSIAVARIAGDDGGVDRADRVELTDGGPKQPDALPSEAPAAPSALPKAAGGAAKTARPSGSPSTSAQPSPSGSASAPTGTPSQKGSGGGASVNPTGAGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZP6</accession>
    <name>A0A0F4JZP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945439.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4704"/>
    <dbReference type="EnsemblBacteria" id="KJY39590">
        <property type="protein sequence ID" value="KJY39590"/>
        <property type="gene ID" value="VR44_01200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2955"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="27959" checksum="7CEEDCC4544A926E" modified="2015-06-24" version="1">MSTAPFPYKLVATDLDGTLLRDDDTVSERTREALAAATAAGAAHIIVTGRAVPWTRGVLDDLGYKGIAVCGQGAQVYDAGAHRLLTSVTLDRQLAGLALSKLEAEVGPLALAASRDGVDGEVLFGPGYQVQGGLPALYLEDTAAVWSAPLNKLYIQHPGMGEDELVKVARETVGGLVDIVMAGPGIVEILPLGLSKATGLSLAARRLKVKAAETIAFGDMPNDIPMFGWAAHGVAMANAHADLKAVADEVTTSNQEDGIAVVLERLLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0J3</accession>
    <name>A0A0F4K0J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945413.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39634">
        <property type="protein sequence ID" value="KJY39634"/>
        <property type="gene ID" value="VR44_01085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29131" checksum="705C5F41F9B74603" modified="2015-06-24" version="1">MHMTSGPHLLTEDRPEFDRLLDEALRTADERPELAALGERLNAEQLRTMALSAIALLTAAAAAEYAHYVKVREELRDEALTGRGSTDEEAAEDGDGQGDGGGAGVSAVVAVLAPVLAGTAMLIFLLVGYSLKAIDPEPAFARTMLTAGWLFGGLTVVALVFAVVSLLVAALRNSSTEVAAEESLPIPDELARAREAWRNALLERGIMPFLRDALADPTAGTGYPVPRTPGAGRIPHLGYTRPDFSSPSDGTPGSRPGYSSPDFTSPDFGGPEHRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K194</accession>
    <name>A0A0F4K194_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">VR44_00145</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945269.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene995"/>
    <dbReference type="EnsemblBacteria" id="KJY39909">
        <property type="protein sequence ID" value="KJY39909"/>
        <property type="gene ID" value="VR44_00145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.27"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJY39909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="36516" checksum="ABF7DF3B5609A604" modified="2015-06-24" version="1">MQELHDAPLAPLTTFRLGGPAARLVTATTDAEVVETVRAADASGTPLLVIGGGSNLVIGDEGFDGTALRIATTGFTLDGTTLELAAGENWSDAVARTVEAGLAGIECLAGIPGSAGATPIQNVGAYGQEVCDTITEVVAYDRTTGETVTLTAAECAFRYRHSLFKDQPDRYVVLRVRFALEDAGGLSAPIKYPETARALGVEAGDRVPAAVARETVLRLRAGKGMVLDPADHDTWSAGSFFHNPILTDEAYAAFLARVQDRLGPETAPPAYPAGEGRTKTSAAWLIDKAGFTKGYGTGPARISTKHTLALTNRGQATTEDLLALAREVVAGVHAAFGVTLVNEPVTVGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1B1</accession>
    <name>A0A0F4K1B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4781"/>
    <dbReference type="EnsemblBacteria" id="KJY39713">
        <property type="protein sequence ID" value="KJY39713"/>
        <property type="gene ID" value="VR44_00815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2868"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="75"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20537" checksum="C2D57BD3B1D4F0D1" modified="2015-06-24" version="1">MTDTRGPQSEPQAKPQSTSKQKQKPAVDETATEAKAKSKDAAGQPYHPPQAYAAPKKPGAQRGPVPGTRTTPRTRKARLRVAKADPWSVMKVSFLLSIALGVCTIVASAVLWMVMDAMGIFSTVGGTISEATGSNEGNGFDLQSFLSLPRVLIFTSVIAVIDVVLMTALATLGAFIYNLSAGFVGGVELTLAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2W2</accession>
    <name>A0A0F4I2W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001802">
        <property type="protein sequence ID" value="KJY16014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16014">
        <property type="protein sequence ID" value="KJY16014"/>
        <property type="gene ID" value="VR44_40645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12028" checksum="80A87798AD1AA6BB" modified="2015-06-24" version="1" fragment="single">TVLDAAPGGEAGEWWGLLEEAERQAPEAVRDVLHYPSTGVWAEETLRRLHAPQGPAPDLGHLGALAVAAALRAGTGFKTTLRPSHGRLALPTLGLLLPDRPGPLALTERSWDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4X7</accession>
    <name>A0A0F4I4X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001742">
        <property type="protein sequence ID" value="KJY16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16523">
        <property type="protein sequence ID" value="KJY16523"/>
        <property type="gene ID" value="VR44_40410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7232" checksum="C20282122E3BAD12" modified="2015-06-24" version="1" fragment="single">PFVSALTGGLVTDQIAHPDYWVKHVREAVRFHDAIRTLEAEGATTLLELGPDAVLTAMARPCLTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5F1</accession>
    <name>A0A0F4I5F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001687">
        <property type="protein sequence ID" value="KJY17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17192">
        <property type="protein sequence ID" value="KJY17192"/>
        <property type="gene ID" value="VR44_40110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6394"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="27313" checksum="6CE78F23A8EBE431" modified="2015-06-24" version="1" fragment="single">MAPWRWFPPLLAVLLLGLWGLPRGPGAGSMWRDESTTWQVAHRPAGELWGLLGQIDAVHGLYYGVMHAVFAVAGVWGEGGPGGPGGGGLWVLRLPSVAGTALAAGGVAAVAHRLAGERAALWAGAVYVVLPPVQMYGQEGRSYALVAAAVAWATYLMLRRWWVAYALVLLVGCWLHEFAVLALFAHGFTAWRARGWRWAAGAVAAGLLPLAVVSTGQAERQLGWLGRPGWQDWTAYGVLVAAVLLLARGGRREVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6P4</accession>
    <name>A0A0F4I6P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001656">
        <property type="protein sequence ID" value="KJY17670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952593.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001656.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17670">
        <property type="protein sequence ID" value="KJY17670"/>
        <property type="gene ID" value="VR44_39890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6283"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="13782" checksum="E2CC994B6754C465" modified="2015-06-24" version="1">MTAQPVHFDGPGDDKARRVPPMPERTPQALRLAIQEHAPHLLPDFEAHWRRSIGDAFNLTPVPAFMRLWWTQYAISRDPALDAHLHELEARASSSEDPEESARLLAEYSRLRRAAAAVEPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I975</accession>
    <name>A0A0F4I975_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001616">
        <property type="protein sequence ID" value="KJY18204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001616.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18204">
        <property type="protein sequence ID" value="KJY18204"/>
        <property type="gene ID" value="VR44_39645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6046"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY18204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="18171" checksum="8051110ED36E0C50" modified="2015-06-24" version="1">MLMYMSNSASASRSTPRHSVSVAGVVVRDDGRLLAIRRADNGTWELPGGVMELAETPEDGVRREVLEETGIHVEVDQLTGVYKNITAGVVALVFRCKPSGGTERLSGESTAVRWLTRDEVTALMSEVYAVRLLDALDGNGPHVRSHDGHHLLPDQPQTAAARRDLGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9X5</accession>
    <name>A0A0F4I9X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001580">
        <property type="protein sequence ID" value="KJY18870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18870">
        <property type="protein sequence ID" value="KJY18870"/>
        <property type="gene ID" value="VR44_39370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469834" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="9749" checksum="26480A2634305ED5" modified="2015-06-24" version="1" fragment="single">MLKKIMTAAAVSAVAVGVGAAAAAPAMAIGNDNGVNTVNGNGXQQIYGNQKTAGDQSPQLGLVQGTLNKPCIGLPAKVNVQSVAALIANIGVQDINVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAJ0</accession>
    <name>A0A0F4IAJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001571">
        <property type="protein sequence ID" value="KJY18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18987">
        <property type="protein sequence ID" value="KJY18987"/>
        <property type="gene ID" value="VR44_39285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="42230" checksum="E6C63DEF9D682CF2" modified="2015-06-24" version="1" fragment="single">GSLGGGLDHAATMLAGPAVVQPPAPPGPPGAPGAPGAPGAPGGGMQHAATMLAGPGTVPPPGPPSAPPGGPAGQQPAPSGVPTVGPGYQAVLRYRAPDGSEQQLIRRSAPGTPHPEWQILYELRAMNVPPQQVLELHTELASCELPGGYCARMIRETWPQVRITSVAPYGTDHAGRQQGMRHLLTHQGELHQVADGPARPAPVRAPLPQVPLQPAIPMDAIAQELAGAFGPQGVFRYDQRAVSRQGVPEIVAQTLMWAGLPVDFGPFFWAQAVPGQPVPTLAELAAQRQVQPASDAGSYLVIGSDFGKALCVQYGTAHIVAVPVEGGPGGAPVPPQFVNSSLPQFARSLAMLGHMWRLRQHLTPEQAGRWTVDFQANLAGLDSAALASPESWWSVLLEQMWDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBI0</accession>
    <name>A0A0F4IBI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001569">
        <property type="protein sequence ID" value="KJY19014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952475.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19014">
        <property type="protein sequence ID" value="KJY19014"/>
        <property type="gene ID" value="VR44_39255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469884" evidence="1">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="9514" checksum="713586CCDB0CCE82" modified="2015-06-24" version="1" fragment="single">MIKKLVAGAAVAASTVGLGAAMAPQAMAIGNDNGINTVNGNNSAQIYGNQATYGNMSPQMALIQGSFNKPCIALPAKVNAQSILSAVNIGVQDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGX8</accession>
    <name>A0A0F4IGX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001493">
        <property type="protein sequence ID" value="KJY20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20713">
        <property type="protein sequence ID" value="KJY20713"/>
        <property type="gene ID" value="VR44_38610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="12377" checksum="7FD046F3731895E7" modified="2015-06-24" version="1" fragment="single">MASGNVRLRIPPTRNGDLVRARVGGEEVLLRIRVPADPTPPGPTTAGPTAPGATVPGPFGPLHVPQPAAPSGSGKSGALGCLLALGVAAAVIIGVAVASSSDDDSGPIASPTHSSTYSPDTSYTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJL2</accession>
    <name>A0A0F4IJL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001447">
        <property type="protein sequence ID" value="KJY21648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21648">
        <property type="protein sequence ID" value="KJY21648"/>
        <property type="gene ID" value="VR44_38190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7129" checksum="D038309A90BAA2EA" modified="2015-06-24" version="1" fragment="single">YDTCLEFIAALRAATGTAGRRVDAEPEAGHPPTAVSVVPEPPQEPPAWALPVFRAQHDGPHGGMPYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILT1</accession>
    <name>A0A0F4ILT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001421">
        <property type="protein sequence ID" value="KJY22433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952224.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001421.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22433">
        <property type="protein sequence ID" value="KJY22433"/>
        <property type="gene ID" value="VR44_37915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5144"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="349"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="506"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY22433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="568" mass="60423" checksum="80D67ED2448CE72A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPP8</accession>
    <name>A0A0F4IPP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001314">
        <property type="protein sequence ID" value="KJY24000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24000">
        <property type="protein sequence ID" value="KJY24000"/>
        <property type="gene ID" value="VR44_36620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4633"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14119" checksum="0244EB4257C270A4" modified="2015-06-24" version="1">MRNEGSGLVLQLEGASRVRVGPDGPPAPEAARRWRLAPTHSGAGVFHVVSEDNGRRLDVANASTDSGARVQVWRANAFGAQEWVVEEHLEAPGVVSLVACVSGLLLEADGEGRARQAEDSDSPSQWWRLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPR8</accession>
    <name>A0A0F4IPR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001309">
        <property type="protein sequence ID" value="KJY24020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24020">
        <property type="protein sequence ID" value="KJY24020"/>
        <property type="gene ID" value="VR44_36555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4616"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7368" checksum="300ECCF392E59169" modified="2015-06-24" version="1">MKEESAVRRRPTTLSTGLVVGLFVLFGVLLCTAWRSSGDGLAQTLAVYLAVAVPGCLFVLWLMRRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQP3</accession>
    <name>A0A0F4IQP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001243">
        <property type="protein sequence ID" value="KJY24350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951794.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24350">
        <property type="protein sequence ID" value="KJY24350"/>
        <property type="gene ID" value="VR44_35625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="25624" checksum="A845920C07D92AEA" modified="2015-06-24" version="1" fragment="single">ALYGTEDLLVDAYRTGDGVGWAEHDPALDTGMGSFFQPTYEHRLVADWLPSLTGVTAKLAAGGTVADVGCGVGHTTLLIAKAFPQATVHGFDYSEEAIAIARGLAEEAGLSDRVVFDVASADDYPGTGYDLVTFFNALHDMGDPVSAAQHVHKSLDADGTWMLVESNVSPDDIDTQTPAARMFMALSAVMCLPVAVAQRGPHALGNHSGEQAFRAIAEEAGFTRWRRATETPVNAVYEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRR4</accession>
    <name>A0A0F4IRR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">VR44_37635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001395">
        <property type="protein sequence ID" value="KJY23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952171.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001395.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4630"/>
    <dbReference type="EnsemblBacteria" id="KJY23366">
        <property type="protein sequence ID" value="KJY23366"/>
        <property type="gene ID" value="VR44_37635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5032"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="417" mass="42859" checksum="062B97588274107D" modified="2015-06-24" version="1">MKVLVIGGGAREHALCRSLSLDPDVSALYCAPGNAGIAEVAELRPVDALDGAAVAALAGELGADLVVVGPEAPLVAGVGDAVRAAGIPVFGPSREAARLEGSKAFAKDVMAAAGVPTARSYVCTTAEEVDAALDAFGAPYVVKDDGLAAGKGVVVTEDREAARAHAAGCDRVVIEEYLDGPEVSLFAITDGVTVLPLQPAQDFKRALDGDQGPNTGGMGAYSPLPWADPKLVEEVLETVLQPTVDELRHRGTPFSGLLYAGLALTSRGTRVIEFNARFGDPETQVVLARLRTPLAGVLLGAANGTLDALPPLTWSDEAAVTVVIASHNYPGTPRTGDPIEGLAEVAAEDGPEAYVLHAGTRQEGDSVVSAGGRVLSVTATGQDLAQARERAYKAVARIRLDGSQHRTDIAAKAAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL9</accession>
    <name>A0A0F4ISL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001139">
        <property type="protein sequence ID" value="KJY24987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24987">
        <property type="protein sequence ID" value="KJY24987"/>
        <property type="gene ID" value="VR44_33755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3669"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8558" checksum="9889FECC7835C398" modified="2015-06-24" version="1" fragment="single">TITLLLDQLEAEIGKLATSSPLAAVRAVRRIETTAAEAGSWAARAVQADATPEQAAVALGLTEAAVRRELARLGRWSLYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISR4</accession>
    <name>A0A0F4ISR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001371">
        <property type="protein sequence ID" value="KJY23751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952120.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23751">
        <property type="protein sequence ID" value="KJY23751"/>
        <property type="gene ID" value="VR44_37375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4893"/>
    <dbReference type="eggNOG" id="ENOG50337EH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="9593" checksum="FDF4AF310CE06013" modified="2015-06-24" version="1">MARVPSSAVAAAGLVGGYAVARWTKKRPLGGVVLGAAGIVAGREWHRRGGVPAAAGLGALYLAGFAGAHPLAKKVGAWPAVVGAAGVVAATAWAVADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IST2</accession>
    <name>A0A0F4IST2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001126">
        <property type="protein sequence ID" value="KJY25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951422.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25065">
        <property type="protein sequence ID" value="KJY25065"/>
        <property type="gene ID" value="VR44_33575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3597"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470375" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="11394" checksum="3F26B38C8E14B1C4" modified="2015-06-24" version="1">MSLPLTRRIARAALLLAAGTAPVVGAAGAASAAGLESVPQLGTLAAPDSADAHAATGAATGAAADVAGTATKAVPAAAPASEVAGSAGQMLGGLPVSQLPVGHDLPVGHDLPGSLPLGSLPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX3</accession>
    <name>A0A0F4ISX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001120">
        <property type="protein sequence ID" value="KJY25105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5144"/>
    <dbReference type="EnsemblBacteria" id="KJY25105">
        <property type="protein sequence ID" value="KJY25105"/>
        <property type="gene ID" value="VR44_33410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3561"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14001" checksum="C79989B0BED3EBB1" modified="2015-06-24" version="1" fragment="single">MKFSIGGSLKLAFRPWVEGLENIPAEGPAILASNHLSFSDSFFLPAVLDRKVTFIAKAEYFTSPGVKGKLTAAFFKGVGQLPVDRSGARGAGEAAIKSGIEVIERGELFGIYPEGTRSPDGRLYRGKPGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISY8</accession>
    <name>A0A0F4ISY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951382.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25120">
        <property type="protein sequence ID" value="KJY25120"/>
        <property type="gene ID" value="VR44_33370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3552"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="27692" checksum="F3C3631097640CFA" modified="2015-06-24" version="1">MTLRVERDEENGVAVVTLDRESRHNAVDLGTAAELAALWREFRFDEEVRAVVLTGAGTAAFCTGIDRSAQVPQPASPYSVDDPLVAIGPKANDLWKPVVAAVNGMACGGAFYLLGEAEFIVSATTATYFDPHTSYGMVSAYEAVYMAQRMPFGEVARMSLMGTAERLSARRAYEVGLVSELAEPGELLAAALRSARTLASFPTEGVQGTVRALWSAKQAALQQALAQAPALIALGNLPPERQAELFEGRRPGTDFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITF9</accession>
    <name>A0A0F4ITF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001095">
        <property type="protein sequence ID" value="KJY25297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951282.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001095.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000079_gene436"/>
    <dbReference type="EnsemblBacteria" id="KJY25297">
        <property type="protein sequence ID" value="KJY25297"/>
        <property type="gene ID" value="VR44_32845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3387"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="99"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="45499" checksum="38AAE6A6632BD0E7" modified="2015-06-24" version="1">METFPKIISVDDHTVEPPHVWRDRLPSRYRDTGPRIVRAPLKEMTFLGGRFAPVMGAKGDEGPVGDWWVYEDLHRPLTRLDTAVGYDRDEIKLEVITYEQMRPGSFSVPERLADMDVNHVQSALCFPTFPRFCGQTFTEAKDRELGLLGVRAYNDWMVEEWCGPLARGRLIPLTLIPLWDARLAAEEVRRNAARGVRAVAFSEIPPHLGLPSIHTDAWDPFLQACDETGTVIAMHIGSSSRMPSTSADAPPAVGSTITFANCCFSMVDWLMSGKFERFPNLRIMYAEGQIGWIPYILERANVVWEENRGWGGVADKVHRPPSELFAEHVFGCFFDDAFGLKNLDSIGVGNVLYETDYPHSDSTWPKSREVGEAQMGHLDPEVVDRIVRGNAIDLLGLTPEGLWAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF3</accession>
    <name>A0A0F4IUF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001250">
        <property type="protein sequence ID" value="KJY24316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951813.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24316">
        <property type="protein sequence ID" value="KJY24316"/>
        <property type="gene ID" value="VR44_35720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4297"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="104"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="46365" checksum="DD50F012A294BF5C" modified="2015-06-24" version="1">MDAREAARLLKGVRAAALAGDRPPAAPRPEIAESWRRMMAGGVHRRRMAGGVHPDRDARSRVLSAAETEERRQVSPLREILPVLREGLLPELDESLHIMVVADADGRLLWREGHSSILRKADRLGFAVGADWDEAVVGTNGVGTSLVTRRPVQVFSAEHFVSSHHDWTCAGAPVHDPRDGQLLGVVDVSGPLATMHPATLAWVSSVARLAERELRVRHLESLERLRTVAAPLLARLPGRAVAVDPHGWTAAVTGLAPADRVQLPKALGPGRLWIPQLGDCVAEPLPGGWLLRLAEPSAAAAVSRVVLDLSRPRSWTATVYGAAGSWSQELSPRHAELLFLLAETPRGRTAAELAEEVFGDPTRTVTVRAELSRVRRHLAGVLSHRPYRFAEDVEVELIRPQDPAGLLPHSTAPAVVRARLGRGGTGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVV3</accession>
    <name>A0A0F4IVV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000978">
        <property type="protein sequence ID" value="KJY26137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950908.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000978.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26137">
        <property type="protein sequence ID" value="KJY26137"/>
        <property type="gene ID" value="VR44_30810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2619"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="34960" checksum="97EFB54C75BEAF94" modified="2015-06-24" version="1">MRVLLIGANGYLGRYVADRLLADPAVQLTALGRGDDADVRFDLATGSPGALTRFLDAVHPGVVINCAGATRGGARELTRHNTVAVATICESLRRSGCGARLVQLGCAAEYGPSQPGSSTAEDAVPRPGGPYGVSKLAATELVLGSGLDAVVLRVFSPVGPGTPAGSPLGRLAEAMRRAMQSGDGELKLSGLGVQRDFVDVRDVARAVHAASLSAAQGVVNIGTGRAVRLRDAAAVLARVAGYGGALNELDVPHGGAHNDPRHGHPGRPQGLAGIGSPRSEATPEQLATAAPQPYPYPDGCGAWQQADVRTARDRLGWRPRINLEESLADIWMEAACRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW84</accession>
    <name>A0A0F4IW84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000959">
        <property type="protein sequence ID" value="KJY26282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950839.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000959.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26282">
        <property type="protein sequence ID" value="KJY26282"/>
        <property type="gene ID" value="VR44_30430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2499"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="37372" checksum="F2F80B864380463F" modified="2015-06-24" version="1">MTGRSLRLRRLRRLTPARGEDGAGRAGRRGAAKVVAPKVVALGGGMGLSASLAALRRITGELTAVVTVADDGGSSGRLREELSVLPPGDLRKALAALCGDDDWGQTWARVIQHRFQSQGDLHGHAVGNLLIVALWEQLGDPVQALDLVGRLLGAQGRVLPMSAVPLELQALVKGHDPARPDEVDTVRGQATVALTPGEVLSVQVVPGDPPAVPEAVAAVLDADWVVLGPGSWFSSVIPHLLVPELLDALVATKARKVLSLNLAPQPGETEGFSPQRHLEVLARHAPKLALDVVLADEAAVPDRESLADAAKRFGAAVELAPVARQDGSPKHDPELLAAAYDRIFRMHGRIGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWW8</accession>
    <name>A0A0F4IWW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001007">
        <property type="protein sequence ID" value="KJY25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25938">
        <property type="protein sequence ID" value="KJY25938"/>
        <property type="gene ID" value="VR44_31180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2724"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470492" evidence="1">
        <location>
            <begin position="32"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="43789" checksum="FFA46DE9C6F7E279" modified="2015-06-24" version="1">MDRSRMRSTAAILTSMTALAATSLVAGPAVAAGPATGGPCALTRTAAHHSLGLDTWNRAYPKPVRTLNAVMVFLSFPDHQTAVTPRELAADYFPATSDFFERASYGRFRLVPHPQQQWIRMPRPSTAYGIQRDWAPDARAAYLRDAVAAADPSVDFSRYDIVYFVADPNAPGVDSDATKVVNFDRPLRADGTDLRRIVTVFERHPPDRNVLAHETGHVFDLPDLYHRPADGKGDWDTYVGDWDVMGSQFGMAPDLFGWQKWKLGWLDASQVDCVRSGTSLHTLQPLSQPLQPGATGGTRLAVIRTGPGSAIAVEARGSAGNDGDTCTEGVLVYRVRNEAASGGGPIEVLDGHPRTEACWDRSVYPPLADAPLEVGETFTVPGERITIEVADRTLSGAYTVKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX39</accession>
    <name>A0A0F4IX39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha,alpha-trehalose-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950717.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26577">
        <property type="protein sequence ID" value="KJY26577"/>
        <property type="gene ID" value="VR44_29750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2329"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="52824" checksum="A6E39B7294697582" modified="2015-06-24" version="1">MASQVLVAANRGPLSYALADDGTLSARRGGGGLVSGLSAALAAQPEALWICAALSAADREAVRRGISEPGVRMLDIDPAVYDDAYNGIANSVLWFTHHHLYDVPREPVFDAEFRRRWDSYTAYNQAFAEALAEEAAPGARVLVQDYHLALVPGALRELRPDLRIAHFTHTPWASPDVLHMLPDDIRSRLVWGMLGADQLGFHTAAWAAAFISGATVDDVHGVADGFVPREGHQGGVHHRRLTEDGSYGEMRFTGVGQYPLGVDGDDLRALAHRPEVDDKLAALRAEVGDRRTIVRVDRTELSKNILRGLLAYRELLTTHPEWRGRVVHLASAYPSRQDLQVYRAYTASVESLAAEINDEFGTEGWEPVLISVQDDFARSLAAYRMADVALINPVRDGMNLVAKEIPVVSEAGCVLVLSTGAGAYEELRQDALTVNPYDVTATAEALHAALTMPEEERAERTKRLAAAATALPPASWFTAQLEALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXE5</accession>
    <name>A0A0F4IXE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26710">
        <property type="protein sequence ID" value="KJY26710"/>
        <property type="gene ID" value="VR44_29380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="13903" checksum="7B634D33D0324660" modified="2015-06-24" version="1">MARRSSAVSRTWLRIIRSTGSGPPSLTVCSYAGRSALASASRFPGRALPSRSALYAASIAPQRWCPSTRTSGVAEVSGPYSTEPVTTASTACPPVRRTYMSPSPVSNSSSGGTRESMQDRTTANGVWLWATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXX6</accession>
    <name>A0A0F4IXX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001063">
        <property type="protein sequence ID" value="KJY25511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951184.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25511">
        <property type="protein sequence ID" value="KJY25511"/>
        <property type="gene ID" value="VR44_32295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3181"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18668" checksum="297328FE9A7E7E47" modified="2015-06-24" version="1">MKATEVLADGFGRIREVVHETLDGLAAEQLNARLDPESNSIAWLVWHLTRIQDDHVAGVAGQEQVWRSAGWADRFALPLPVEDHGYGHTAKQAGTVRVDSAGLLLGYYDAVHEQSLRYVRGLAAGDLERIVDERWDPPVTLGVRLVSVLADDLQHAGQAAYVRGLLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXY3</accession>
    <name>A0A0F4IXY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000932">
        <property type="protein sequence ID" value="KJY26504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818584.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000932.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2656"/>
    <dbReference type="EnsemblBacteria" id="KJY26504">
        <property type="protein sequence ID" value="KJY26504"/>
        <property type="gene ID" value="VR44_29910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2363"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="15353" checksum="A68DF2E7E506DA7E" modified="2015-06-24" version="1">MNDDPQSNVQETTFFEQVGGEATFRRLVHRFYQGVAEDPLLRPMYPEGDLGPAEERFALFLMQYWGGPGTYSENRGHPRLRMRHAPFQVDSAAHDAWLKHMREALDELGLAPEHEAQLWRYLTYAAASMINTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY22</accession>
    <name>A0A0F4IY22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001056">
        <property type="protein sequence ID" value="KJY25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951153.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25566">
        <property type="protein sequence ID" value="KJY25566"/>
        <property type="gene ID" value="VR44_32135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3145"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="34244" checksum="F23056D0DDF4834E" modified="2015-06-24" version="1">MDARITRIQAKLAALPTTEKAVLGPALTETQISDFEDTHGVRLPEEFRQFLTRIGHGGYGPTYGLLPMERWVGRGGMGQPAESFPIVPDVDVPTGPDDRGDLVGSFPGTITVVYRGCSDFTLLVVTGPGRGRLVEVNAEGFFAPRFYADSDFLSWYERWLDFVLTGHQDLNWFADQMAGNEDQLVATLLNDDLPTRRRAAAYTFITHPAPSTTLPSTLIRALAAETHPAVRKSILRALAAQGEHGRDLLTMALGDPVAKVRSLAVVLMASNTPRGWRLPTQRREALSQRFSNETDESVRETIQRMLKHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY91</accession>
    <name>A0A0F4IY91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_29600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000915">
        <property type="protein sequence ID" value="KJY26634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950690.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000915.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26634">
        <property type="protein sequence ID" value="KJY26634"/>
        <property type="gene ID" value="VR44_29600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2300"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="463" mass="51064" checksum="28DFB5600EA04C0A" modified="2015-06-24" version="1">MTVSVVLFTSDLRVHDHPPMRAALEGGGEVVPLFVRDRAVDRAGFAAPNRLAFLADCLVDLDRALRRLGGRLVVRSGDLVEEVSRAVRQAEAEEVHMAAGYTAFARAREARLRQALEARGCRLHVHEGVCTAVPPGDVTPQGSDHFAVFTPYFRRWQAEPLRTPLPAPQGLRVPAALRSEELPGRSGLSGVSPGLARGGEQEGRERLRSWLSHHAHAYEQRHDDLAGDATSRLSAHLHFGTLSAGEVVFRAGRSGGAGAAAFVRQVCWRDFHQQVLAARPEAAGQDYRSRDDRWRRGREAEADLSAWREGRTGYPVVDAAMRQLAHEGWMHNRGRLVAASFLTKTLYVDWREGARHFLSLLVDGDVANNQLNWQWVAGTGTDTRPNRVLNPVLQGRRYDPDGAYVRRWVPELAGVGGLDGAAVHEPWRRSGLDRAACDYPDPLIALPDGLARFRHARGLVPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ27</accession>
    <name>A0A0F4IZ27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000888">
        <property type="protein sequence ID" value="KJY26909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26909">
        <property type="protein sequence ID" value="KJY26909"/>
        <property type="gene ID" value="VR44_28925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="232"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="597" mass="62560" checksum="86225CAE81E99304" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1A9</accession>
    <name>A0A0F4J1A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ORF">VR44_26150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="JZWV01000766">
        <property type="protein sequence ID" value="KJY28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950056.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000766.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000058_gene2285"/>
    <dbReference type="EnsemblBacteria" id="KJY28070">
        <property type="protein sequence ID" value="KJY28070"/>
        <property type="gene ID" value="VR44_26150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1386"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="605"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="798" mass="85576" checksum="3674FA0BBCE1FB62" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1R6</accession>
    <name>A0A0F4J1R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000752">
        <property type="protein sequence ID" value="KJY28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950006.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000752.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28225">
        <property type="protein sequence ID" value="KJY28225"/>
        <property type="gene ID" value="VR44_25885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1282"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470310" evidence="2">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="67"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="22149" checksum="6A39FADFDC82FDF7" modified="2015-06-24" version="1">MRANRSLVRRTTALAAAVTAALVLAACGGKSDGASGHGGGHDASAPASASAAPSGTAQGAAANNAADTAFAKGMVPHHRQALEMASLAATRAESPEVKALADEIRKAQDPEIKTLSGWLASWGEQVPAAEGGGHSGHSMSGGSGMMTGEEMDQLTKASGKEFDTAFLRLMVKHHEGAVAMARTEQTDGRYQPAKDMAAAIIASQSAEITRMNGLLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1Y5</accession>
    <name>A0A0F4J1Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28290">
        <property type="protein sequence ID" value="KJY28290"/>
        <property type="gene ID" value="VR44_25680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1235"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12346" checksum="D2FC385AC6ABAC67" modified="2015-06-24" version="1">MYASVDDVITALGRGGFDCKVTLRNENKFGSDATCEVQHRQTTVYNKISVLSTSRFSRDEVGDSIATGRRAYGQTFVAAGNWFIWVSPSVYAHDMAAALPGSVVLEPLPLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J270</accession>
    <name>A0A0F4J270_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000781">
        <property type="protein sequence ID" value="KJY27944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27944">
        <property type="protein sequence ID" value="KJY27944"/>
        <property type="gene ID" value="VR44_26385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1460"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="41908" checksum="C07D260C11AF0E69" modified="2015-06-24" version="1" fragment="single">MPLLEPDPGALRPARPGTPAPDRVPDRAASGTPRTLREELTGLLGAEKVLWQVSDLVRYATDASPYRFVPQAVVVAEDIDDISAVLSYAHGRQREVVFRAAGTSLNGQAQGEDILVDVRRHWRGVEVLDGGRRVRIRPGTTVFRANAALARHGRVLGPDPASAVACTLGGVVANNSSGMTAGTTRNAYRTLSSLTFVLPTGTVVDTADPLADEELARAEPALCRGLLELKREIEADPALVARIRAKYEIKNTTGYRLDAYLDGTTPVEILRGLAVGSEGTLGFIAEVVFDTLPLDRELTSALLFFPSLPAAAAAVPLFNEAGALAVELMDGNTLRASVSVAGVPADWAELPRDTAALLVEFRAPDAAGRAEYERRAAAVLPRLELVAPVASVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2A8</accession>
    <name>A0A0F4J2A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000775">
        <property type="protein sequence ID" value="KJY27989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27989">
        <property type="protein sequence ID" value="KJY27989"/>
        <property type="gene ID" value="VR44_26295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1400"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="4">
        <location>
            <begin position="129"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="3">
        <location>
            <begin position="502"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="634" mass="67211" checksum="9943BFB9452F0FE9" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2B1</accession>
    <name>A0A0F4J2B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28422">
        <property type="protein sequence ID" value="KJY28422"/>
        <property type="gene ID" value="VR44_25420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1180"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="21035" checksum="463D843952EB5701" modified="2015-06-24" version="1">MTLDRIRTRAGERGLDVDGILDPRALSERAGVPLELTAALLRGEEVPEAAAGGTEERVRRRAVFLYAVSRDACGRPYRVADIAAAIGAPPRWVGALVSGRKPPHLRHCRAFAAFFGREASFLTDTPAQAVSRALRPTLESLDYRSGNLMADLVDQYGLVSVSTRGRPLTRTQETLLLGMITGMLSAERHAGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2W6</accession>
    <name>A0A0F4J2W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000753">
        <property type="protein sequence ID" value="KJY28194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950007.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000753.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28194">
        <property type="protein sequence ID" value="KJY28194"/>
        <property type="gene ID" value="VR44_25900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1285"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="20769" checksum="AA1C9339E060E0A5" modified="2015-06-24" version="1">MNNGITAALLAGFGTGLSLIVAIGAQNAFVLRQGARRHAVLWVVAICAVSDALLIALGVAGVGAFVTAWPAALTAVGIAGGGFLICYGVLAARRVLRPAPGAALSAEGAASGSARAAVLTCLAMTWLNPHVYLDTVLLVGSLAADRGDLRWAFGIGAGLASLTWFSTLGYGARLLSGVLAKPGAWRVLDGLVAATMVTMGGMLLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J316</accession>
    <name>A0A0F4J316_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000765">
        <property type="protein sequence ID" value="KJY28088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950046.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000765.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28088">
        <property type="protein sequence ID" value="KJY28088"/>
        <property type="gene ID" value="VR44_26110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1378"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19379" checksum="D9F064FF6D9318A9" modified="2015-06-24" version="1">MTEIRTPRLLLRRWTDDDLVPLSEITSDPDVMRWTGDGSALDLDATAEAIELWEEEWDDEGFGVFAVELLASGELIGAVGLSAADDLPETRHQVQIVWRLGRPFWGQGYASEAAQATLEFALQDRGLDRVVAVNRVGNEESANVIRKLGMVQDGETVDPATGAPVTLHSIDLTEYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J332</accession>
    <name>A0A0F4J332_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949830.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28645">
        <property type="protein sequence ID" value="KJY28645"/>
        <property type="gene ID" value="VR44_24945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.989"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19426" checksum="ECADB859AEA2B3A5" modified="2015-06-24" version="1">MSAPVPTHAPARTSAPTAAELLDFALRTAADPEIIDSLPLDPEGRTWIRLDGPGGSEAWLIGWPPGTGTGWHDHAESRGAFATARGRLTEHSLTVRLPSEGWRTLELTPEVDRTRSLGAVTGRAFGEHHVHEVLNESDSEHAISVHAYYPPLPLIRRYSRSGAVLRLEHVERPADWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J366</accession>
    <name>A0A0F4J366_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949750.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28797">
        <property type="protein sequence ID" value="KJY28797"/>
        <property type="gene ID" value="VR44_24500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.895"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="25701" checksum="1C00AFCEA0C0906B" modified="2015-06-24" version="1">MLPIDVAAHSSRWRGRHPLEKALLGFGLTVTAVCLPPWPGGPLVAAATLAVLLGPAGVSGRQLWRAFRVPLGFCVTGALPLLVSVGGPDGFLAPAPDGPRHALDLLLRTSAASLGVLLFAFTTPVSDVLPRLVRAGVPAPVVDVALVMYRIGFLLLDSLAQVRRAQAARLGQAGRAAAWRSVAGLAATSFVRAFDRAARLQEGLAGRGYDGALRVLVPPAALSRRFLAAAAALLAGLVAGTLVLKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J369</accession>
    <name>A0A0F4J369_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000709">
        <property type="protein sequence ID" value="KJY28690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28690">
        <property type="protein sequence ID" value="KJY28690"/>
        <property type="gene ID" value="VR44_24825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="21971" checksum="1FD154FF7F8B05CA" modified="2015-06-24" version="1" fragment="single">VQLLLAQDASSGPAADWLEHAKTPAARIAISSWLQAHPEGALPAAAAPRAPLSVPGLRGGGGNAVADLPDAHVRLAGCCTPVPPDAVAGFVVRGGAVTVHRVHCPAVAQMRSLGRTSVAVHWRATADCRVTLLAESFGRPHLLADLTEAIARQGVEVVSATVEPPVEQRVRHSYTLQLPDASVLPGLMRAMRDVPGVYDVSRAWGCLLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3J7</accession>
    <name>A0A0F4J3J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000698">
        <property type="protein sequence ID" value="KJY28850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949729.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28850">
        <property type="protein sequence ID" value="KJY28850"/>
        <property type="gene ID" value="VR44_24380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.862"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="17973" checksum="7F081F4B73A5E0DA" modified="2015-06-24" version="1">MTSTEAAAIALQDHAALWSAGEISAGEVVDAACDALVAGLDTPGLRMLAACTRAEAGYDVYDLLPPALDELGLILHPVADVAAQEAVARALARRVLSGELKPWELTFRLHQRYGHELPLTQRLAELDELYAFLEDGDRAVDQVNAEVMAEARRLAAHPGVPTGPADIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4P4</accession>
    <name>A0A0F4J4P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_24780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949799.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4666"/>
    <dbReference type="EnsemblBacteria" id="KJY28698">
        <property type="protein sequence ID" value="KJY28698"/>
        <property type="gene ID" value="VR44_24780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.957"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27546" checksum="EDE33F527AA364C8" modified="2015-06-24" version="1">MTATTTSHASTSTAAPTALLRPDGGPCRVLVVDDEASLSELLSMALRYEGCEVRSAGDGAGALRAAREFRPDVVVLDVMLPDMDGLSVLGLLRREIPQVPVLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRGLVRRSGAAQAARGGSVLSVGDLSLDEDSHEVVRGGQEVHLTATEFELLRYLMRNPRRVLSKAQILDRVWSYDFGGQANVVELYISYLRRKLEGGTGLPPMIHTRRGAGYLIKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4P6</accession>
    <name>A0A0F4J4P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000785">
        <property type="protein sequence ID" value="KJY27911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27911">
        <property type="protein sequence ID" value="KJY27911"/>
        <property type="gene ID" value="VR44_26480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11309" checksum="0F521A8C0036B278" modified="2015-06-24" version="1" fragment="single">FLHARPAQLPELFAAVALALLSAGAVRFVLWPIERRTPPAAAPPPLPGTGLARPTTRQAFQATVACGFALAVGQILSEDRWYWAVGTAWWIFVNTASRGETLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5H1</accession>
    <name>A0A0F4J5H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949612.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29089">
        <property type="protein sequence ID" value="KJY29089"/>
        <property type="gene ID" value="VR44_23765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.726"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470171" evidence="2">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="21464" checksum="DFF6E07964E53FB6" modified="2015-06-24" version="1">MSRSLRRGALAASAVVFSLASLAACGAGNDAQTLQIKPDNAAVTKGDIKIQNALVITKGDKEKKGPASVSATLFNAGTKDQTLDAITLAGGKSKVTLKDSAGSGKITVPAGGSVVLGGKGNASAVVEGGREAVQNGNVQEMTFQLSNAGDVKLDAYVVPATGMYAGYGPTEAPAAGATPAPSGSASASPSGSPSGSPAASPSGAASGSPAASGSPSASASHGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6G3</accession>
    <name>A0A0F4J6G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949214.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000603.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29937">
        <property type="protein sequence ID" value="KJY29937"/>
        <property type="gene ID" value="VR44_21610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.200"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23353" checksum="33E147F3AB6D8FE5" modified="2015-06-24" version="1">MQSATAATATRVPKPRADAVRNRERILGAAREMFVEFGADAPLDEIARRAGIGNATLYRHFPDRADLVHHVVLYVMDRVTAQAEDALAEEPDAFAALCRFTHAAADERIGALCPMLQDGFDHDHPELLAARDALGVAVDTLVAAGQRAGLLRADIGTGDLMLALSQLARPLPGTDCTTVGGFVHRHLQLFLDGLRTPARSQLPGTAVTLQDITRKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6I3</accession>
    <name>A0A0F4J6I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949206.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29962">
        <property type="protein sequence ID" value="KJY29962"/>
        <property type="gene ID" value="VR44_21565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.191"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="29445" checksum="FD3AA2099BDB87F7" modified="2015-06-24" version="1">MTQPTPAPLQTALRLAGLGLPVLPLRQDKTPVGNCPTCAGSACGDRPHMKAAGPCQCPAPCHGWAAATTDPHVLTSPAWARAWQRAGAVAYHPGGAGLTVVDLDTPGAVAWARQTLPATTTVATTRGEHWIYQGATRSVNGVRPGVDLKSTMAYARWRGPGTGTMTTLPDAVRALAVKKPAPVRPVLAAVVPAPAGGGGCRHRSPAYLERGIAMAEQRITAADSAIHHTVYRTFLAVLSVHGRCGCLTETHVERLFTAAQAKGESLRHCTTAWTNARTALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W5</accession>
    <name>A0A0F4J6W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_21175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949136.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000589.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5046"/>
    <dbReference type="EnsemblBacteria" id="KJY30112">
        <property type="protein sequence ID" value="KJY30112"/>
        <property type="gene ID" value="VR44_21175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8958"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="31313" checksum="25346D64E5FA3AC4" modified="2015-06-24" version="1">MSETASEPRSKGVRPRGARSPLASFGLHATLLVASVIAVFPVLWILLTSLKPAKYAISTDFVKEPTLGNYTYLLESSHFLSWFWNSVLVAGVTTVLGVFIAATTGYAVSRFKFPGMKPLMWTLLITQMFPMAILIVPLYNLMGELGLLNQPLGLIITYLTIAVPFCAWMMKGFFDTIPVEIDESGRVDGLNPFGTFWRLILPLAKPGLAVTGFYAFITAWGEVAYASAFMVGEENLTLAGGLQTFVTQYTSNWGAMSAASVLIAIPAAVFFLFAQRHLVAGMTAGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J807</accession>
    <name>A0A0F4J807_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948958.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30512">
        <property type="protein sequence ID" value="KJY30512"/>
        <property type="gene ID" value="VR44_20225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8752"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="18968" checksum="57F366E7CB79B29D" modified="2015-06-24" version="1">MTNQTGDPGQTGQGALIAAVGDRRPSLDPTAFTAPTSVVVGDVTLGAGASVWYSAVLRGDCGPITLGAGSNVQDNCTLHVDPGFPVSVGERVSIGHNAVVHGCTVEDDCLIGMGATVLNGAVIGAGSLVAAQALVPQGMVVPPGSLVAGVPAKVRRELTAEEREHIKLNAAMYTDLAGQHRAALLPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J847</accession>
    <name>A0A0F4J847_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949198.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29954">
        <property type="protein sequence ID" value="KJY29954"/>
        <property type="gene ID" value="VR44_21525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.183"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="10027" checksum="6B844501632A2C80" modified="2015-06-24" version="1">MRPVTVTTFVQYASKPGTDRWHEPISVDVARQCLRRARRSGDTVEIRQTTARDGSSVHVAHVHIGPGRWRDVDSVTDIYEIPTDALTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8B3</accession>
    <name>A0A0F4J8B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948903.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4942"/>
    <dbReference type="EnsemblBacteria" id="KJY30637">
        <property type="protein sequence ID" value="KJY30637"/>
        <property type="gene ID" value="VR44_19925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8605"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="266"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="41502" checksum="977F238F85685B9B" modified="2015-06-24" version="1">MAAEPVIVEAVRTPIGKRGGALANLHPAYLLGETYRELLARTGIQPDCVEQIVGGTVTHAGEQSMNPARNAWLAMGLPYETAATTVDCQCGSSQQANHMVANMVSGGVIDIGIACGVEAMSRVPLGSGSKHGPGKPFPDEWNVDLPNQFEAAERIARHRGLTREDVDRLGVLSQERAATAWAEERFKRETFAVQVPTTEEEQAAGQGMWRLVDRDEGLRDTSMEGLARLKPVMPTAVHTAGNSSQISDGAAAVMWASRKMARALKLKPRARIVAQALVGADPHYHLDGPIDATRAVLGKAGMSLRDIDLVEINEAFASVVLSWAQVFGQDLEKVNVNGGAIALGHPVGATGARLITTALHELERRDKEFALITMCAGGALATGTIIQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8C0</accession>
    <name>A0A0F4J8C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000596">
        <property type="protein sequence ID" value="KJY30034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30034">
        <property type="protein sequence ID" value="KJY30034"/>
        <property type="gene ID" value="VR44_21375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11521" checksum="90951CF5DDA71EEA" modified="2015-06-24" version="1" fragment="single">MTTPATAWPLENAVFSAAMLAHRLPWADAPARALGLDSLTREGAARGVLAHLHRSRSGRPVRLRTPFGSFLVPLGPADTAGLLAAGAASDALAPAVRLDAAGRRHGLHPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCJ8</accession>
    <name>A0A0F4JCJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000485">
        <property type="protein sequence ID" value="KJY31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948530.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000485.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31534">
        <property type="protein sequence ID" value="KJY31534"/>
        <property type="gene ID" value="VR44_17940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8132"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470365" evidence="2">
        <location>
            <begin position="20"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="85"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="543" mass="58789" checksum="8B3220D453A7D005" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD24</accession>
    <name>A0A0F4JD24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813840.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32100">
        <property type="protein sequence ID" value="KJY32100"/>
        <property type="gene ID" value="VR44_16670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7767"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9834" checksum="D3E89D3C648B3214" modified="2015-06-24" version="1">MDLSTPRRRVYGADHDDPDPGPRPGHAYGELVGGPLDGLLLDVTGWSPARLAEEARLPTEIGRYGPGGRAHYRRRAADPDRWDWSGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD39</accession>
    <name>A0A0F4JD39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S6 modification protein RimK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948275.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32115">
        <property type="protein sequence ID" value="KJY32115"/>
        <property type="gene ID" value="VR44_16565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7745"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="96"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="31625" checksum="2FDFB7FF5E7C64A7" modified="2015-06-24" version="1">MRLCFLVEEHYRHDGMPNEVIRQLTAWGHRVDVVRPGGSLLRMTDLVRAGTHDAWVLKTVSGGPGLTLLEAAAAAGVTTVNDARSIRGVRDKALAAALGSARGLPLPPTYAVARPELLAEVPDELYPLVVKPADGSSGRGVHLVPSPDRLPALLPELAGEGVLIVQPYVANPGTDIKVYCVNGELHATERCSPLHPDAAVRERRVPLSAEVAGIAARVGEVYGLDLYGVDVLLGPDGPVVVDVNDFPSFRQVPDAAARVAGAVLELARAGGGRTSAPGRAQARPLPLPVTIPAQAVARAGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEC1</accession>
    <name>A0A0F4JEC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948289.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32098">
        <property type="protein sequence ID" value="KJY32098"/>
        <property type="gene ID" value="VR44_16660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7765"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="13306" checksum="8102E31C5F06AFE4" modified="2015-06-24" version="1">MPRFLTLIRIDEQDLPPQDFPPEFEQRMGALLEEVTKAGVMLDTAGLLPTAQATRLDWSGGKISFTDGPFTETKEVVGGYALLQCKDKAEALEWTKRFLETHPTSWHVGAEVREIQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF10</accession>
    <name>A0A0F4JF10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32399">
        <property type="protein sequence ID" value="KJY32399"/>
        <property type="gene ID" value="VR44_16065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7634"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="31140" checksum="0247553C3AAAA304" modified="2015-06-24" version="1">MTMTRTPLRRFLDYAVLSVPAFIFVLPVLYLILGSFKPSDQVLSGLTGFLPTHLSFDNYRAVLSSFDSDATGYFWRFMGISLLLSTVVVLGGLIVNSMAAYGLTRLKWRGQGAVFAVVLLLMLVPFEAVAVPLFYMFNDQRNTIYVQAVPFIANAFSIYQFAMFFRAIPPSIEEAARIDGAGPWRTFFAIIVPMSKPVFASVAILTFLTQWGSFLWPVLMVSDPAVRPLPLQMSVFQGQMPVDWGQVLAFGVLLVLPVLIVFAFFQRWFVQGVASSAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFC3</accession>
    <name>A0A0F4JFC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000411">
        <property type="protein sequence ID" value="KJY32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948153.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000411.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32453">
        <property type="protein sequence ID" value="KJY32453"/>
        <property type="gene ID" value="VR44_15940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7597"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="15010" checksum="7CBA39511C3C3031" modified="2015-06-24" version="1">MAAVGNVTGPMPSFDPYERGCPSRDLLDQIGSKWAVLVLGELGRNGTSRFGRLRQALAGVSEKMLTQTLRTLERDGLVSRTVYPAVPPHVEYELTALGQTLREPLKALTEWSVLHIEEVITAREEYDDRTERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFR9</accession>
    <name>A0A0F4JFR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948412.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31831">
        <property type="protein sequence ID" value="KJY31831"/>
        <property type="gene ID" value="VR44_17310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="30956" checksum="15C2C3D05D8BF21F" modified="2015-06-24" version="1">MITIVGATGATGSALLQRLIELEVPCRAVSRTPDNLRATIGTNTPVEIVGADAADPRTLRDAFEGSTQLFLAMANSPLQAELETNVIDAAAHQGVRHVVKLSAPAAEPTSPVAISRSHWRIEEHLATTGMTATLLRPYAFMQKLPLNAPAIARGVLIGAMGDAPCNYIDVRDIADVAAETLLRPGLAGATYTLTGPQAFSHPELARLLSELTCRPVRYIDLPPSEFYGHLLTNAHMPPWLADHVVEIQQLAIARPESPNNTVETVLGRPARTLHTFLGEHLHAFTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGP3</accession>
    <name>A0A0F4JGP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947778.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33507">
        <property type="protein sequence ID" value="KJY33507"/>
        <property type="gene ID" value="VR44_13825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7044"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470717" evidence="1">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17083" checksum="BA16C4008B86D3D4" modified="2015-06-24" version="1">MLAAFAGTVLFSLALAHVTLEPSAASAGLVHSNTRPGASIGPYLDGVSVREAAEQLGGNVLLGVPFGVLLPVLLPQARGLVRVAAVTAVVMTLVELIQGALVTGRAFDVDDVILNTTGALLGYLLLGRRMGRAVHPRRHHWWHRLTRRGGRAPAGGSAPVPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH13</accession>
    <name>A0A0F4JH13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947723.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33642">
        <property type="protein sequence ID" value="KJY33642"/>
        <property type="gene ID" value="VR44_13565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6974"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="516"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111055" checksum="6942EE75F8D2E2CE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHG1</accession>
    <name>A0A0F4JHG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_13215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947661.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene714"/>
    <dbReference type="EnsemblBacteria" id="KJY33787">
        <property type="protein sequence ID" value="KJY33787"/>
        <property type="gene ID" value="VR44_13215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6861"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="37291" checksum="DE514EADE0096815" modified="2015-06-24" version="1">MSDLHPFIAGLPKAELHVHHVGSASPRIVAELASRHPDSKVPTDPEALADYFTFTDFAHFIEVYLSVVDLVRTPDDVRTLTFEVARDMARQNIRYAELTITPYSSTRRGIDERAFMEAIEDARKAAESELGVILRWCFDIPGEAGLEAAEETARLAVDLRPEGLVSFGLGGPEIGVPRPQFKPYFDRARAAGLHSVPHAGETTGPETVWDSIRELGAERIGHGTSSTQDPELLAYLAEHRIALEVCPTSNIATRAVADLDEHPVKEMVQAGVLVTINSDDPPMFGTDLNNEYAVAARLLDLDERGLAQLAKNAVEASFLDPAGKARLTAEIDAYTAEWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHG6</accession>
    <name>A0A0F4JHG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">VR44_13245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947666.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33792">
        <property type="protein sequence ID" value="KJY33792"/>
        <property type="gene ID" value="VR44_13245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6868"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="41792" checksum="2EE5A11872F7A096" modified="2015-06-24" version="1">MTDTTASGDVRLAGISKHYGSFTAVHPLDLTIPQGSFFALLGASGCGKTTTLRMIAGLEEPSTGTVSLGEREVTHLPPYKRPVNTVFQSYALFPHMDIFENIAFGLRRRGIKSVKKQVDEMIDLVQLGEHARKKPHKKPHQLSGGQQQRVAVARALINHPQVLLLDEPLGALDLKLRRQMQLELKRIQTEVGITFVHVTHDQEEAMTMADTVAVMNGGRVEQLGAPAELYENPRTTFVANFLGTSNLIEASVESTGSDVAVSASGAILRLPAARCSTTPRTGGKLLVGVRPEKISLVPAEDEHTIAAGRNKITGKIADSSFIGVSTQYVIDSPVCPELEVYVQNIERDARLVPGADVVLHWNPEHTFGLDAAQDIDAGIETVEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHQ9</accession>
    <name>A0A0F4JHQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">VR44_14185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000365">
        <property type="protein sequence ID" value="KJY33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947838.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000365.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3363"/>
    <dbReference type="EnsemblBacteria" id="KJY33298">
        <property type="protein sequence ID" value="KJY33298"/>
        <property type="gene ID" value="VR44_14185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7183"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="35634" checksum="CE19332675B8D995" modified="2015-06-24" version="1">MKRHLISAADLTRDDAVLILDTAEEMARVADRPIKKLPTLRGRTICNLFFEDSTRTRISFEAAEKRLSADVINFAAKGSSVSKGESLKDTAQTLEAMGVDAVVIRHHASGAPYRLANSGWIDAPVINAGDGTHQHPTQALLDAFTMRRRLVGRDAGLGKGLDGRRITIVGDVLHSRVARSNVDLLHTLGAEVTLVAPPTLVPVGVENWPCEISYSLDEVLPKSDAVMMLRVQRERMNAAFFPTEREYSRRYGLDAARMAKMPEHAIVMHPGPMVRGMEITAEVADSDRCTVVEQVANGVSIRMAVLYLLLGGSEPAVTTARTEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIK9</accession>
    <name>A0A0F4JIK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947725.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33644">
        <property type="protein sequence ID" value="KJY33644"/>
        <property type="gene ID" value="VR44_13580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6977"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470765" evidence="1">
        <location>
            <begin position="30"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="444" mass="47744" checksum="328A745BBB00E8EB" modified="2015-06-24" version="1">MTRYPLIRTAVATVAAAGLLSLSACGLGGAGPRAGEARKTGRVAGEITFRTLQLKPVYTAYVQGVIDSFERAYPEAEVKWEDVPGDGYNEKLVADAQAGALPDVVNLSTDSFQLLADRGMLADVASLDAAAAKEYVPGAWEQFKLPGKGEGVYAYPWYVTPEILTYNQDLFTRSGLDPARPPTTVEQFFDYAEQIAARSGGRYAAFMADPKGRLPGDWQKMGVPLLNKAGDRFTFDTDKAVAWADRMKDLYAKGAMPKESLLKADDINQLYGSGRLVFGPGSPGFVKDIKANAPQVYAQTRVAGAVTGTLGHIGIYAQSLGIRKDTAHPDAAAEFAKWVTNGPNQVEFSRRATIYPSNAQGLADPRFADRGDGKDAETLARAIGAEQLRTAALDANTPVQWTSQVGDAVAREMQKAIKGEEDARTAVRRAEEEANRLLAAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIL4</accession>
    <name>A0A0F4JIL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33649">
        <property type="protein sequence ID" value="KJY33649"/>
        <property type="gene ID" value="VR44_13540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6969"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470525" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="14269" checksum="EDECD49305489A50" modified="2015-06-24" version="1">MCVVLAAGACAAAPARPGSAHAAHAAHAAGTASATPSASASASASASASATVEQIAEALGCTPELGTQAEELRQGACQTGQGVYRMTTFAAEAGLRSWLAEAEPYGGFYLVGNRWVVTAQSADALAGLRERLGGSVETGAAHTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIX0</accession>
    <name>A0A0F4JIX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_13390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947692.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33754">
        <property type="protein sequence ID" value="KJY33754"/>
        <property type="gene ID" value="VR44_13390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6914"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="37071" checksum="48D068254B1B722E" modified="2015-06-24" version="1">MPSPATLLPLAATATDDAAESVTNAASFIEENWATWLSIGLRILLIIVIAAALRSVVRKALTKLISRMNTSAEAVEGTALGGLLVNAERRRQRSEAIGSVLRSVASFLILGTAALMVLAALKIDLAPLLASAGVAGVAIGFGARNLVTDFLSGVFMIMEDQYGVGDKIDAGVASGEVIEVGLRVTKLRGDNGEIWYVRNGEIKRIGNLSQGWATAGVAVQVKPTENLARLREVLQEVADAFAKESPWDERLWGPVEVLGLDEVLLASMTVKVSAKTMPGQQFAVERELRWRIKEAFDAAGIRIVGGLQAADDEEAPADPAASVAAPSVLANPASPQSLATTPIPPPAAPPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIZ1</accession>
    <name>A0A0F4JIZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000338">
        <property type="protein sequence ID" value="KJY33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947677.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000338.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33779">
        <property type="protein sequence ID" value="KJY33779"/>
        <property type="gene ID" value="VR44_13305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6883"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="34877" checksum="7D424CBFEA443C6D" modified="2015-06-24" version="1">MPTAEEDRASRRLARCVAHLLRHAPHHVVAALLDRLDEPVRRYLCRDEWLPAAAVTLLLRHGTDADRHYIARNAHVVGRPLPGLPGPARYAARPGPSPELLAHVGPGPFTTDELTALLRRHGRRPRVPLTLLRMPHELDPGQLLREHARAPLPAGAVEALLLAGGLTRTECLALLDARAGGTYGRHWYRPAVRAVRMGLLTCDELVAHVAPAARTLLLGHLPVTRGLRWTLPEQAEMQSAVHRALRPPLGEDPRLWAALGRAAPPRRRLPRHPARAGRRAGRGHTGGARRRTARPGTGPGRTPPRARDGPRRPGRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ02</accession>
    <name>A0A0F4JJ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33758">
        <property type="protein sequence ID" value="KJY33758"/>
        <property type="gene ID" value="VR44_13345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21986" checksum="642F4529FF5AB3F2" modified="2015-06-24" version="1" fragment="single">MDRDDVDRALARLGAEHEAVETSLLALQDHAGRRLLEGAALSGVTKERWAAADAAVTRLWTYFDAYSGALAAAREIRERRRWPSREDLAELTERLRGPGVTIAGAGVEGAALAERFSLAELVARMNELYAASLDVVVAADAVWSALPARIDLLAAELHRTRALARSVGVRPGEHPSGDDLEEITAELAQLREAVIADPLAFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJI1</accession>
    <name>A0A0F4JJI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947890.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33126">
        <property type="protein sequence ID" value="KJY33126"/>
        <property type="gene ID" value="VR44_14480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7156"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15596" checksum="B676DF30BE765B01" modified="2015-06-24" version="1">MDTGSDRGTNESATGDTAAEEATHVSKAPAFIKANRSLHLSWQVGVFIVGLAVIGAGVAMLVLPGPGWVAIFAGLAIWATEFAWAHLVLRWTKRKVTEAAQKALDPKVRRRNIILTSAGLAIAGALVGFYLWKYGLTLPWNLKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJX6</accession>
    <name>A0A0F4JJX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000274">
        <property type="protein sequence ID" value="KJY34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947349.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000274.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34642">
        <property type="protein sequence ID" value="KJY34642"/>
        <property type="gene ID" value="VR44_11550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8705" checksum="65D721BD7E12A925" modified="2015-06-24" version="1">MVFLDVQLSAPELSATVQALKELVERLPQTCDQAADVMDLLGSEDRMVMDTGRPPGAFVAGSVHESGFWPNFYGGTTLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLV7</accession>
    <name>A0A0F4JLV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000264">
        <property type="protein sequence ID" value="KJY34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34753">
        <property type="protein sequence ID" value="KJY34753"/>
        <property type="gene ID" value="VR44_11380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6172"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9170" checksum="A87BEA70AF886B53" modified="2015-06-24" version="1" fragment="single">YPATVRGHVRTAEALLGWILLSNVPTGLLPDDKDAPGKQSGLRNLAVALQAGPGTPRTTLPDPTACCVSTSGRGHDKDPQRDTASPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLX0</accession>
    <name>A0A0F4JLX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000237">
        <property type="protein sequence ID" value="KJY35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947177.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000237.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35195">
        <property type="protein sequence ID" value="KJY35195"/>
        <property type="gene ID" value="VR44_10620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5868"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24354" checksum="097E5D9F477F8BE2" modified="2015-06-24" version="1" fragment="single">MASQLFAVCFNTGRPSDLARFWSGILGWERADGTDGDVAILPPDATGFRIRFLPSREPRTGRNRAHFDLTSSSPEEQQETVARALELGASHIDVGQLPEEGHVVLADPDGNEFCVIAAGNKFLAGTGFIGALACDGTQEVGYFWSEVLRWPLVWDQDQETAIQSPDGGTKITWGGPPVAPKTGTNRLHLELTLPADADREAEIDRLLSLGATHADTGEGGRTLMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMD6</accession>
    <name>A0A0F4JMD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenazine biosynthesis protein PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35375">
        <property type="protein sequence ID" value="KJY35375"/>
        <property type="gene ID" value="VR44_10230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="32970" checksum="3428589F8DAD08B7" modified="2015-06-24" version="1">MNLRTHPEILRYTAFTTDPAGGNPAGVVLDAAALGDAAMLATAAEVGYSETAFVIAADHAARRFRLRYFSPLAEVAFCGHATVATAVALAERLGPGPLVFDTPVGEIALDTSADREGSVTATLTSVPTRSRPAADEEVDASLAALHWSPEDLDTALPPHVAFGGNEHLVLAVATRERLAALDYDFDALAEVMHRHGWTTLQLVWRETQDLFHARDPFPIGGVVEDPATGSAAAAFGGYLRTLGALPPSGAFTIRQGEDLGRLSLLRVEASTTDPRVRVSGQAVAIAGTSARTGEGGAERTERAAGDVQSHRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNA7</accession>
    <name>A0A0F4JNA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000207">
        <property type="protein sequence ID" value="KJY35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946965.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000207.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35675">
        <property type="protein sequence ID" value="KJY35675"/>
        <property type="gene ID" value="VR44_09480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5297"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="12965" checksum="8C84F25530025A4D" modified="2015-06-24" version="1">MHSNLIVARMDVRSSAEVAKIFAEFDRTDMPERMGTLRRRLFSYNGLYFHLQDFAEDDGGERIQQSRNDPRFMRISYDLQPFIQPYDPETWRSPADAMATRFYDWTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNK9</accession>
    <name>A0A0F4JNK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_10335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000228">
        <property type="protein sequence ID" value="KJY35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947123.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000228.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35353">
        <property type="protein sequence ID" value="KJY35353"/>
        <property type="gene ID" value="VR44_10335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5937"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="785" mass="86809" checksum="E29E6D83653284F8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQD7</accession>
    <name>A0A0F4JQD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946618.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36572">
        <property type="protein sequence ID" value="KJY36572"/>
        <property type="gene ID" value="VR44_07625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4137"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470777" evidence="4">
        <location>
            <begin position="28"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="43995" checksum="FF215EA6A9FB0DFF" modified="2015-06-24" version="1">MRTYSKRRRRSLVAVSAVLGGVLMLSACNGGGDDKSQGGGSGKSQAEVDAAAAKDASKAKIAITPKDGATNIATTDGASVTVSDGTLTKVELKSSDGAAVEGKIAADGKSWKPAGALKRSTKYALSATAKDEAGREAHENASFTTLSPENSFIGDYTPEEGQTVGVGMPVSINFNKPIKDTKAVQAAITVTSSSGQEVVGHWFGNQRLDFRPEQYWQANSTVTLKLALQGVQGAPGIQGVQNKTVTFKIGRSQVSTVDTKTKKMTVTRDGQVLKTIPISAGSPENPTYNGQMVISEKFKETRMDGSTVGFKNSEGKGEYDIKDVPHAMRLSTSGTFIHGNYWGDDSIFGNVNTSHGCVGLNDAKGANDPDTAGAWFFENSLIGDVVTVVNSPDKTIKPDNGLNGWNMSWAEWKAGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQJ6</accession>
    <name>A0A0F4JQJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946694.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000056_gene607"/>
    <dbReference type="EnsemblBacteria" id="KJY36450">
        <property type="protein sequence ID" value="KJY36450"/>
        <property type="gene ID" value="VR44_08045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4436"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="379" mass="40736" checksum="3B95A58ABB927EED" modified="2015-06-24" version="1">MSNPIRRVTELALDEKTVAALRAALRTTADEVVQAIIDEVPPYANALSGRMGVTIRRAVRTALGHYLDLASGNATGGDAGEAAYELGRGEVRDGRSMDALLSAYRVGARVAWRCLAAGAVPAGLPAAEVARFAELTFAYIDELSAASAAGHADELAARGREHERHLEHLARDLLAGANPDVLLASAQRAGWQPPASLTAVLLPAAQARPAYRALDPGTLVLDDLPDATGVLLVPDADRSHLLRQLTDRAAVVGPARPWTRASASYARAVRARSLPFDIRDTEDHLPELVLSADPDAFADLRARALAPLRTLPAATARRLEETLRAWLLHQGRRDEVAAALFVHPQTVRYRMSQLRELFPDLASPHRVLELTLAVGPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRG2</accession>
    <name>A0A0F4JRG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein SsgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000216">
        <property type="protein sequence ID" value="KJY35516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947066.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000216.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35516">
        <property type="protein sequence ID" value="KJY35516"/>
        <property type="gene ID" value="VR44_10015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5551"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17765" checksum="57D62D59DA4664F8" modified="2015-06-24" version="1">MHHHPVIERELELRLILSPERSIRVPAKLLYLTDDPYAVHITFHTGTSAPVNWTFARELLVEGVFRPCGHGDVRIWPTKIDSESVLCMALSSPDGDALLEAPAGAVSAWLERTLRVVPPGTEAERLCLDEALAELLTPTPADELWLRDPWPSDESAEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRK2</accession>
    <name>A0A0F4JRK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36454">
        <property type="protein sequence ID" value="KJY36454"/>
        <property type="gene ID" value="VR44_08065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="13176" checksum="4670801C4E3B5F0F" modified="2015-06-24" version="1" fragment="single">MSGLTAFPLPFQASRSVPYATPRTLRELEMMRCSAHIREKAGWFEKIRDAEVVARWTREAIEQGLTEAQVRYVLDELAHYAALRDGRTGIEVSGVDGVWQSDALVDEELGARLREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS24</accession>
    <name>A0A0F4JS24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000151">
        <property type="protein sequence ID" value="KJY36553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946645.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36553">
        <property type="protein sequence ID" value="KJY36553"/>
        <property type="gene ID" value="VR44_07765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4257"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="26286" checksum="66A03AAA1A39DF94" modified="2015-06-24" version="1">MKLGLHDKTAVVTGAGRGIGLATVRLLVEEGVRVVGAARTVTPELAATGALGVSADLSTAAGVAALADAAHAELGGVDLLVNNVGGGDPEGGLTGFLDSDDAQWARYLDLNLMSAVRLTRAVLPGLVERRGAVVNVSSVCARLPATGPVAYSAAKAALGAVTKALAEEFGPRGVRVNTVSPGPTRTAVWEDPENFGGLVAEAAGVEHSALLERLPADFGLTTGRLTEAREVASVIVFLLSGLAGNVTGADYLVDGGMVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS73</accession>
    <name>A0A0F4JS73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_07400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946573.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36684">
        <property type="protein sequence ID" value="KJY36684"/>
        <property type="gene ID" value="VR44_07400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3953"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20932" checksum="92DFFB0635BAC8EC" modified="2015-06-24" version="1">MMGRTIFIDPGRCIGCQACVSACRECDSHRGKSMIHLDYSDPGQSVASLPTVCMHCEDPVAPCAEVCPADAILVTADGVVQQADTTRCIGCANCVNACPFGVPKIDLQAKLQMKCNLCYDRTAYGLAPMCATVCPTGALFYGTLEELQAERPGVQVADSFAFGDVVVSTGVAMVVPADKVQWPVPGGLPVVEVNGVDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSV8</accession>
    <name>A0A0F4JSV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="6" type="ORF">VR44_05690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946258.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2527"/>
    <dbReference type="EnsemblBacteria" id="KJY37427">
        <property type="protein sequence ID" value="KJY37427"/>
        <property type="gene ID" value="VR44_05690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1953"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="52"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="587" mass="64712" checksum="6FED4610A92CCE9E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSX5</accession>
    <name>A0A0F4JSX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946814.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36056">
        <property type="protein sequence ID" value="KJY36056"/>
        <property type="gene ID" value="VR44_08660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4975"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="37684" checksum="6A464B75F13B1E8D" modified="2015-06-24" version="1">MKALVFHGPGQTSWQDVPDPSIKDGADAIVRVDAVTICGTDLHIVKGDVPEVAPGRVLGHEAVGTVVETGGDVRTVRPGDRVLISCISACGRCRFCREARYGQCRGGGGWVLGHTIDGTQAEYVRVPFADLSVYPLPSALPSHEAVLLADIFPTSYEVGVLNGQVRPGDTVVVVGAGPIGLAALATASLYSPYRTIAVDLATSRLAAARDFGADATVGAREEPEKLVEDLTDGLGADVVIEAVGLPEAFEMCTRMVRPGGRVANIGVHGKPATLHLEDLWIKDVTLTTGLVDTHSTPMLLRMTAAGRLPAAAMVTHRFALDEMEEAYDVFSRADETGALKIVLGGPQHDAVAVPPQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU83</accession>
    <name>A0A0F4JU83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946314.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37318">
        <property type="protein sequence ID" value="KJY37318"/>
        <property type="gene ID" value="VR44_05980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2410"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34857" checksum="DBA4E84ED7B42F3C" modified="2015-06-24" version="1">MNQNAPLPLAHLTASRPRVLTLAQLREHGVSAAEAAGRPWQQVLPGVFLLHAGPATSEERLHAALLYAGRRGNGEAMITGLAALALYRFSSTPTLPGLPHIDVLVPNTRRLRSTGDVRIVRAHTPPRPLEVTGLPVAPVARAVADAVAQLDEADAVRRVLSEAVRAGHCEPAAVVRELTVARLLNRPHVIDAVESLLAEGRAIAEDRLYQLVRGYELPEPVWNVDLRLPGGPHLGGVDAYWPEQAVAVEIDTRAPRQGEDEDFAEAVRKRETLERLGVTVLYLTPRKLRDWPEQQAAVVRTALTASCDREPAAYLVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUN1</accession>
    <name>A0A0F4JUN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946090.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37890">
        <property type="protein sequence ID" value="KJY37890"/>
        <property type="gene ID" value="VR44_04780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1036"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26830" checksum="2A862BF25685F20E" modified="2015-06-24" version="1">MDSTRPALRLFVLHHAGGSHLPYRHWPAGLPDSWDVRLLDAPGHGFLLDLPPLDDAGRLADFLLNTVEPELTCPYALFGHSMGALVAYEMTRRAAGRGLPLPVWVGVSARTAPQPAGPAEPYHELPDAELRTRLNLLGGTPDGIFDDPELWAVFEPVIRADLRLVEEWRPGPGAGPLPVALSAYAGAGDAHASPARMAGWEAYTERFQGLRVLDGGHFYFQDDPRPLLRLVERDATAALDAAGAARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV36</accession>
    <name>A0A0F4JV36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946207.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7140"/>
    <dbReference type="EnsemblBacteria" id="KJY37603">
        <property type="protein sequence ID" value="KJY37603"/>
        <property type="gene ID" value="VR44_05420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1720"/>
    <dbReference type="eggNOG" id="ENOG50329NR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12632" checksum="2BA0D62C2D96CA3B" modified="2015-06-24" version="1">MAKYDISALHPVFVRQMDALAALDIEAVMKNYTEDAVLVRFEGASVGIEAVRETFTGYLTLKPTLVELQEYIETDDTIFYRAIMNLNGAPEHAFGTLVVRDGRIWRQTAGFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV68</accession>
    <name>A0A0F4JV68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion protein snm4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946169.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37739">
        <property type="protein sequence ID" value="KJY37739"/>
        <property type="gene ID" value="VR44_05190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1353"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="446" mass="45071" checksum="50C0A7EB936F667C" modified="2015-06-24" version="1">MGAVSGTALSRVTLVGQRRRMDLVLPSQEPVGRLLPDVIRMLDDRVATQPMLRHLVTADGSVLEHGVSLEEAGVADGAVLRLVRVQDVPSAPVVHDVTDEAAEDLDVRAWRWRPSARRVTAGAGLVLWALVAGWFARAAFAPGTVAGVLLAAAAVCGVSGAVAGRLKGSGLAAALLATAGAVGVLGAWTLGDAQHWHAMGRLAAVALALAVALALLGWFTPLGRGGFVGAAAVAGLTVIWEGVALAQGHAGARTGAVLAVVSVVLLGLLPRLALAAAGLTGLDDQRARGASVSRYRVATALGATHRGMALATLATAVSAGAAGVVALTEPDVWTVSLASAVAAVLWLRARAFPLVAEVVALLLAGAAVTVAALLVWAARAGAAGPLALLLALALAALGVLAVQPPEHVRVRLRRFGDAAESFGVIVLFPLLIGVFGVYGRLLGTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV77</accession>
    <name>A0A0F4JV77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_06940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946494.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5282"/>
    <dbReference type="EnsemblBacteria" id="KJY36881">
        <property type="protein sequence ID" value="KJY36881"/>
        <property type="gene ID" value="VR44_06940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3603"/>
    <dbReference type="eggNOG" id="COG3486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="469" mass="52519" checksum="E00C0CC786D0128F" modified="2015-06-24" version="1">MTAQHDAPHDLVGIGIGPFNLSLAALSHGLPAQGADRLATAFYDQRRDFRWHPGLLIDGATLQVPFLADLVTLADPASPWTFLNYLKHKERLFPFYFAERFHIQRAEYDAYCRWVAGRLPGLHFGHQVDAVRWNPERDLFEVDYTQLDPDGEAEALGRTYTRNLALGIGTAPYVPEPLRPLAEAPTVPVIHSADYLDNRARILGAEHVTVIGSGQSGAEVFLDLLRARPAGRERLTWLARTPSFAPMEYSKLGLEHFTPDYTRYFHSLPEPVRDRLVPAQWQLHKGIDSATIAAIHEELYRRTLHGGWPDTVLTPGVTVRTAGRVATTKVELHLEHTQQGSRSRLTTDAVVLATGYKERPLTRLFAGLDPYMRKDSSGRPRIDDRYRMILDPSVSGTVFVQNGERHTHGVGTPDLGLAAWRSAAILNTLTGKDPYPQPDRTAFTTFGLEQREHTRPRPAVDLLPLVDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVG4</accession>
    <name>A0A0F4JVG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946167.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37743">
        <property type="protein sequence ID" value="KJY37743"/>
        <property type="gene ID" value="VR44_05155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1346"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="247"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="347"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="442" mass="47949" checksum="7B8F8BBC3F1AEE55" modified="2015-06-24" version="1">MGRPVTAPVPPPPGGERRLHVLTPLRRAWVPIAATAGLVAQQGERAQEWALALPVWLRLAVLAGLVLVFGTYGFLSWWFTHYAVTDSELRIRTGLVFRRTAHIRLDRVQAIDVTRPLLARVAGVAALRIDVIGTEDKDELAFLAEPDAVALRAELLARAAGFAPAEATALGEAPDRELLRVTVRDLAVSLLLALDTWAALAAGLVGPVLVWALSSSPWAALVALLPLLGAVWKGSAARFLTGYDWRVAESPDGLRLDHGLLDRAHETVPPGRVQTVRIVEPLLWRRRGWVRVELNVAGSKNGILVPVATREAAHALVARVLPGADVAALSFAPSPRRGARWAVPVWWKGYGLAVSRELFAARRGLLCRRTEIVPHAKVQSVRRTRGPWQRVCGVADVHVDTGAGNTVTARLRAAEEATALLYGQAARSRTSRAAARPDRWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXI7</accession>
    <name>A0A0F4JXI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004939779.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6622"/>
    <dbReference type="EnsemblBacteria" id="KJY38539">
        <property type="protein sequence ID" value="KJY38539"/>
        <property type="gene ID" value="VR44_03405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7898"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12465" checksum="E823DFAB6F8C9D02" modified="2015-06-24" version="1">MDLSLSTRTVGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSYHLVVDMERVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTSVDDAVQATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYP6</accession>
    <name>A0A0F4JYP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945477.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39487">
        <property type="protein sequence ID" value="KJY39487"/>
        <property type="gene ID" value="VR44_01405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4713"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9500" checksum="4332269B0B85A1B2" modified="2015-06-24" version="1">MSHESVPEYPGQTGQAAHDHARQEPAVPAQGGAPKGLLQQMEELMAALNADLSQLDADLQHSADRTPPAAPVTPGSRAYDSEHRSDRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYY5</accession>
    <name>A0A0F4JYY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_01210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945441.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4702"/>
    <dbReference type="EnsemblBacteria" id="KJY39592">
        <property type="protein sequence ID" value="KJY39592"/>
        <property type="gene ID" value="VR44_01210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2958"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="33131" checksum="218E7284D215F5DC" modified="2015-06-24" version="1">MSATRFTYLGPEGTFTEAALRTLPEAATRELVPMVSVPAALDAVRNGEAAAALVPIENSVEGGVTATLDELASGEPLMIYREVLLPIAFALLVRPGTKLSDVKTVTGHPVAQPQVRNWLRTHLPDAVWESAASNADGARLVQEGRFDAAFAGEFAAATYGLEALVTEIHDAQNAETRFVLVGRPARPAAPTGADKTSVVLWLGDDHPGALLELLQEFAVRGVNLMLIQSRPTGEGIGNYCFAVDAEGHISDRRVSEALMGLRRTCPQIRFLGSYPRAGVALSEVRAARPGTSDGDFTEASDWLARCLDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ62</accession>
    <name>A0A0F4JZ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_00685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4806"/>
    <dbReference type="EnsemblBacteria" id="KJY39692">
        <property type="protein sequence ID" value="KJY39692"/>
        <property type="gene ID" value="VR44_00685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2843"/>
    <dbReference type="eggNOG" id="COG4320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="482" mass="51071" checksum="44013FF8B24E9C46" modified="2015-06-24" version="1">MVTASGQYATDAAAAAGAARAGGRIPRVPGFAPRAVTGSAKEAGKALRLRVPRAAHASFEMPADRPDAVRAVEESNVGRVAELTPIRVGRMAANPFAFLRGSAGLMAHDLSGGPVTGVGAQICGDAHAANFGLYGDARGRLVIDLNDFDETVFGPWEWDVKRLATSLVLAGRVAGADEDTCRSAAQDAVGAYRRTMRLLAKLPALDAWNAIADEELVSHTDARDLLGTLERVSQKARNNTSARFAAKSTEAGEDGSRRFVDALPVLRRVGDAEAAAVAASLGPYLTTLSGDRLPLLARYSIHDVAFRVVGTGSVGTRSYVVLLLDHRGEPLVLQVKEARPSVLLPHLPALGFHSPAEEHEGRRVVAGQKRMQVVSDILLGWTTVDGRPYQVRQFRNRKGSVDPAALTPDQIDDYGRMTGALLARAHAHSADPRLLAGYCGKNEELDEAVGAFAVAYADRSEADHADLVAAVRSGRIAAEFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0F0</accession>
    <name>A0A0F4K0F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945756.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38726">
        <property type="protein sequence ID" value="KJY38726"/>
        <property type="gene ID" value="VR44_02920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7316"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="740"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="829" mass="87063" checksum="BBEB1AC5D18C5AA0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K346</accession>
    <name>A0A0F4K346_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_01150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945430.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39581">
        <property type="protein sequence ID" value="KJY39581"/>
        <property type="gene ID" value="VR44_01150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2944"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="26729" checksum="D9CAF3307FAE3C6C" modified="2015-06-24" version="1">MTNKASLLRRTAAELIGTAGLLVVVIGSGIQAASLSRDTGVALVANSLATAIGLGLIITLFGPLSGAHLNPVVTLTAWWARRAGGEGLAAREAFAYAAAQIAGAITGAVVAEMMFGRTPGTFSTRVRDGGHLLLGEVVATAGLVLVIQGLGRIGRPRLLPAAVAAYIGAAIWFTSSSSFANPAGTIGRAFSDSFTGIAPQSLPGFVAAQLAGGVLGLVLATLLYGREYAKERDRTTVEPVPSGQSDGQLPLADMPRPGAGSAAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3L9</accession>
    <name>A0A0F4K3L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000008">
        <property type="protein sequence ID" value="KJY39776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39776">
        <property type="protein sequence ID" value="KJY39776"/>
        <property type="gene ID" value="VR44_00545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.109"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="93"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="30177" checksum="361B4E22B758EB1D" modified="2015-06-24" version="1">MSLSGCGNSVDPIERLGRKATQTGGPSASPSAKASAAASAQAGTPGDEAYRKWGLTAPLQYAPKPAQKPQLPKPAGPGKPVVVDRIPVAPNDKVVFLTFDDGAEKDPEFLRMAADLKLPISMFLTDNVASSDYGYFEKLRDNGSNSTVNNHTLTHPNMRTLSFAAQKNEICGQQERLQKRFGKRPVLFRPPFGNYNDDTLKAASECGINTVVLWRASMQINDFQYAEGSALKPGDIVLAHFRGPSELKGATEIHMVTKMLQHIQEQGYQVGRLEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I502</accession>
    <name>A0A0F4I502_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Preprotein translocase subunit SecA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001695">
        <property type="protein sequence ID" value="KJY17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952641.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001695.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene898"/>
    <dbReference type="EnsemblBacteria" id="KJY17060">
        <property type="protein sequence ID" value="KJY17060"/>
        <property type="gene ID" value="VR44_40165"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033REQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34086" checksum="990BFD0EB4417392" modified="2015-06-24" version="1" fragment="single">MRPDTPAEHIAEAERLIRTATRYPEDQEPLLLQAAAHLELGDARDRASALYDRLLSSSPANPHLIKARQAANLWEYGHEAEARALISGIRAAAPTDPAPWEVIAEALESHDELEASHECFTEAATLLTSEDTPLTQATTALLTGRHRVRRLLGLPHDDWDMVADTRHIGPIPLDELHDPKRIWALGSNDPAELRAEIARLRAELGDRRAALSRPFPVAILHWPARELAELLTSYPTLAAEYPTHEAHLNKVEASLRALAASGTTNLGIVTASVPSYEAFAASEKSSPSSPSLLAEYATTLAARGKATPWPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5Z9</accession>
    <name>A0A0F4I5Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_39995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001671">
        <property type="protein sequence ID" value="KJY17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17392">
        <property type="protein sequence ID" value="KJY17392"/>
        <property type="gene ID" value="VR44_39995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6336"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22883" checksum="E39B1CC63A2A3A0A" modified="2015-06-24" version="1" fragment="single">LRTRDQTPALLRGLTTGPARRTAARAAEPAGAGAAGPSLRERLLELPAEERDAVLLDLVCGQVALVLGHARASAVDGERQFRELGFDSLTALELRNGLGPVTGLTLPATVVFDYPTPAALAGYLRAELVDAYAERALAERLDSLEPVLASLAQDTVLRGKAEARLRALLERLGTSGAAVSQPVDDASGARAASEEREIESATTDELFDLIDKEFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I623</accession>
    <name>A0A0F4I623_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001779">
        <property type="protein sequence ID" value="KJY16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001779.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16181">
        <property type="protein sequence ID" value="KJY16181"/>
        <property type="gene ID" value="VR44_40570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6937"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12310" checksum="53650714C8710B3A" modified="2015-06-24" version="1">MLPLLEPEVVPCCPPLAERPLTAEEAERTAVMFKALGDPVRLRLFSAVASHEGGEACVCDISDVGVSQPTVSHHLKKLKEAGLLSSERRGTWVYYRVEPAVLAAMGQLLTKAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6U0</accession>
    <name>A0A0F4I6U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001687">
        <property type="protein sequence ID" value="KJY17193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17193">
        <property type="protein sequence ID" value="KJY17193"/>
        <property type="gene ID" value="VR44_40115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469471" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="5660" checksum="0CA9CD81375B0217" modified="2015-06-24" version="1" fragment="single">MRAAGAAAAVLLAAVALAGCGDDGSPGAPTPAGATAPATATAPPSPATSAPGPTTPAPARTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAG3</accession>
    <name>A0A0F4IAG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_39505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001596">
        <property type="protein sequence ID" value="KJY18654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952524.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001596.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5937"/>
    <dbReference type="EnsemblBacteria" id="KJY18654">
        <property type="protein sequence ID" value="KJY18654"/>
        <property type="gene ID" value="VR44_39505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5990"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY18654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="22070" checksum="44C50B6CF15DF069" modified="2015-06-24" version="1">MELKGALEAVLMVVDEPATAEHLAKVLDRTPREVADALTALADEYTVQRRGFELRLVAGGWRFYTRPEYAEAVEAFVLDGQQARLTQAALETLAVVAYRQPVSRSRVSAVRGVNCDGVMRTLLQRGLVAEAGTEPETGAILYRTTNYFLERMGLRGLDELPELAPFLPEADAIEAETQEGVPSFDPDAPDTDVDDDKTTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAX7</accession>
    <name>A0A0F4IAX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001584">
        <property type="protein sequence ID" value="KJY18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952505.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001584.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18824">
        <property type="protein sequence ID" value="KJY18824"/>
        <property type="gene ID" value="VR44_39405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="27587" checksum="0A33DE95140550D3" modified="2015-06-24" version="1" fragment="single">MDGLKVLPSGRPGRGRLYVNRPDGQAVAWYDRQTNRISVLSDGRREDVLAVLRPYLSGDWTIGPPPVPTRAELRRLHLPPDRDLAPNRPGETLLGELEYGAPGGSRARHRMRRQLVALQRTGVELDLLEAEDWRVVHDVPLPGLGLLDHLLIGPPGVFVLRTVPGRRQRAQVGDLLLTVGRAAPAPDPRWIRRAASHASRALASPVTAALCLTDASRVEVAPTLRDVLVLQPPTLTPTLHAAPATLKPPDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE52</accession>
    <name>A0A0F4IE52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001527">
        <property type="protein sequence ID" value="KJY19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19939">
        <property type="protein sequence ID" value="KJY19939"/>
        <property type="gene ID" value="VR44_38905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469398" evidence="1">
        <location>
            <begin position="35"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="28065" checksum="0F8542FBEF6D0B98" modified="2015-06-24" version="1" fragment="single">MVVLYGDPAGVMSLRPLLPALLSTLLLAPAPAYAAAGGPGDGIETARTTRQLAPGIRLESYDRLEADRWLRIDELVADLDPPTGVRAEYLGTGGGPVTLPEAAARYRPGPGRRVVAAVNGDFFDIRATGAPLGPGVGSGRLLHSASPGPGGGAAVGFGPDGAGRLLRLGLDGTVTLPGGRVHPLAGYNAAKPPAEGFAVYTADWGGKRLPALGPGPAVELRDGRVVSAGPAPAARPAPGTTLLTARGPGPAAALAALRPGDEVTVTARPLPASGPAPVTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFB9</accession>
    <name>A0A0F4IFB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001489">
        <property type="protein sequence ID" value="KJY20725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20725">
        <property type="protein sequence ID" value="KJY20725"/>
        <property type="gene ID" value="VR44_38580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="153"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="370" mass="37583" checksum="8D0A7CEFB2936CE5" modified="2015-06-24" version="1" fragment="single">AVADRAATLGTAIAGRAVSLGNAIADRAATLVGIGGETDSAAGAPDGGPRLIPWPLSAKTPAALAAQAARLRAHLAALPGAPGAPAPTAVDIALSLATTRTAFPHRAVLLAPDRAGLDRALDALADAEPGAPAPAGTDVVRGTADDTRQAAFVFPGQGSQWAGMAVELLDSAPVFAERIRQCEEALAPHVDWSLTEVLRAAPGAPGFDRVDVVQPVLFAVMVSLAELWRSHGVHPAAVAGHSQGEIAAAAVVGALSLEDAAKVVALRSRALTVLSGRGGMLSVSLPLDRLTPLMAPWGERLSVAAVNSPSSIVVSGDGDALTELRDALHADGIRARLIAVDYASHSAHVEAVRERVLEALADITPRACEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHW3</accession>
    <name>A0A0F4IHW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_LIGASE_A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001511">
        <property type="protein sequence ID" value="KJY20251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20251">
        <property type="protein sequence ID" value="KJY20251"/>
        <property type="gene ID" value="VR44_38755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="1">
        <location>
            <begin position="98"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24225" checksum="B2566F97FF0EEA9E" modified="2015-06-24" version="1" fragment="single">MRVALAASVRTLPRGPGLAYEPKFDGHRMVVLRTAEGVVLQARSGRTVTAAFPDLEAAARQLPAGTVLDGEVVVWHAGRTDFALVQRRAAATPARAAALARTLPASYAAFDVLELSGLDVRAQPYERRRALLVDLLVPLGPPLQPVPMTTDPDLAETWYETLPASGIEGLVVKRLDQPYPSGRRAWRKLRHTNVRDAAVIGYTGTARRPLALVLVLPGEDEDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPY0</accession>
    <name>A0A0F4IPY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001302">
        <property type="protein sequence ID" value="KJY24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951946.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001302.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24057">
        <property type="protein sequence ID" value="KJY24057"/>
        <property type="gene ID" value="VR44_36430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4538"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="35012" checksum="A8EC9620EB2BA8D7" modified="2015-06-24" version="1" fragment="single">VSNAALAVASVGYLAVLFPAVGDHKWSMCLAALAVQWLPALSNLAGTRYVGAVQVVATVLKLVPLLLVAVGGLFFFDPANLGPFQATGQSPVGAVSASAAILLFSYIGVESAAVSAGEVRDPARNVGRATVLGTVGAATVYLLGTLAVFGLVGHDKLVSSGAPFTDAVDAMFGGTWGGTLVAGAAVISMVGALNGWTLLSAQTPYAAAKDGLFPKVFEKKQRGVPVAGVLVTVVMASALTVWNYVAGSAAVFDALVLITTFTATVPYLLSTAAQLYFLASGQSGRVRRGQLVRDAVLAGLAFAFSMWLVAGSGYAAVYQGVLFLFAGVLVYALMSARKRRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQT0</accession>
    <name>A0A0F4IQT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001236">
        <property type="protein sequence ID" value="KJY24385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24385">
        <property type="protein sequence ID" value="KJY24385"/>
        <property type="gene ID" value="VR44_35570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4227"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16905" checksum="18CAC17BB42205AF" modified="2015-06-24" version="1" fragment="single">SGPVRDEAYGVLRIPRLGLAVPVAEGVDRRAVLDKGYVGHYPGTAQPGAEGNFALAGHRNTHGEPFRYLNRLREGDEVLVDLRGRRYAYVVGKVLAETSPGDVGVIAPVPRSGVKPGYGYQEAGSYITLTTCTPEYTSKYRMVVWGELRSVVSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR40</accession>
    <name>A0A0F4IR40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">VR44_35285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01001225">
        <property type="protein sequence ID" value="KJY24457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951731.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001225.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5925"/>
    <dbReference type="EnsemblBacteria" id="KJY24457">
        <property type="protein sequence ID" value="KJY24457"/>
        <property type="gene ID" value="VR44_35285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4169"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="11"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24099" checksum="BF4021C7981A3E16" modified="2015-06-24" version="1">MESAAPSAVIVAIDGPSGTGKSSTSKAVAAKLGLRYLDTGAQYRAITWWMITNGIDTDDPQAIALAAGKPAIVSGTDPSAPTITVDGQDASGPIRSQEVTSKVSAVSAVPEVRTLITDLQRSIAAEAAAEADGIVVEGRDIGTTVLPDADLKIFLTASAEARAARRSGELRGKEATDLAATKEALIKRDAADSGRKTSPLAKAADAVEVDTTELTLDQVIECVVTLVEERRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISJ5</accession>
    <name>A0A0F4ISJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_35375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="JZWV01001228">
        <property type="protein sequence ID" value="KJY24438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951748.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001228.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5941"/>
    <dbReference type="EnsemblBacteria" id="KJY24438">
        <property type="protein sequence ID" value="KJY24438"/>
        <property type="gene ID" value="VR44_35375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4188"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="10">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY24438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="39312" checksum="B496E5878D6C7178" modified="2015-06-24" version="1">MKVGIPREVKNNEFRVAITPAGVHELVRNGHQVFIEQNAGVGSSITDAEYVAAGAEILGTADEVWATADLLLKVKEPIAEEYHRLRKDQTLFTYLHLAASRECTDALLESGTTAIAYETVELANRALPLLAPMSEVAGRLAPQVGAYHLMRSAGGRGVLPGGVPGTHAGECVVIGGGVSGWNAAQIAIGMGFHVTLLDRDINKLREADKIFGTKIKTIVSNAYELEKAVVEADLVIGAVLIPGAKAPKLVTNELVAKMKPGSVLVDIAIDQGGCFEDSRPTTHAEPTFQVHDSVFYCVANMPGAVPNTSTYALTNATLPYIVQLANLGWAEALRRDPALALGLNTHDGKVVYGPVAEAHNLESVELSALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISN8</accession>
    <name>A0A0F4ISN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001221">
        <property type="protein sequence ID" value="KJY24478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951725.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001221.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24478">
        <property type="protein sequence ID" value="KJY24478"/>
        <property type="gene ID" value="VR44_35250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4133"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="468" mass="49061" checksum="4CE533753BD34905" modified="2015-06-24" version="1" fragment="single">ELDGRVVRPGDGDYAEARQLFQPRYDSVAPGAVAYPAHAGDVAVCLDFARRSAARVVPRGGGHGYAGWSTVDAGLVVDLGAMAGVAVEGDEVHVGAGARLADVHAALAGRGLGVPAGLCPSVGIAGLTLGGGLGIASRAHGTTSDRLTGARVVTPDGVVREAGPDRDPELFWALRGGGGGNFGVVTEFRLRTHPVGDAAFAELHWAGADSAAVVRGWQRWLGGLADPFWSQAEFTVEAGSAAALAVRAVCLDGRAELERELSRLAGLVGRGPRDSWITVRSYGNTVRALAGCPGGGPERCRLPGRLPGRDPRGLLGRDSYAARSDFWGGPGLPDAAVGAVLDALGRYGREVPPGGTGVVQFDGVCGGAVNRVPAGATAFVHRDSAFLAQYLAYWPPSATPAEATRHQDWLDGLWRALRPWAGGRAYQNYADPKLTGWREAYYGPNLARLEQVRRTYDPERLLRFPQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT19</accession>
    <name>A0A0F4IT19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001194">
        <property type="protein sequence ID" value="KJY24608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951645.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001194.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6526"/>
    <dbReference type="EnsemblBacteria" id="KJY24608">
        <property type="protein sequence ID" value="KJY24608"/>
        <property type="gene ID" value="VR44_34825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4036"/>
    <dbReference type="eggNOG" id="ENOG50329XM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017349">
        <property type="entry name" value="UCP017349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14450" checksum="7AB1B7E7B1019A31" modified="2015-06-24" version="1">MSIHQNLLGGPAPTHLPDEPAPREALAAGTAAAEVAAAHPTSSLAWAALADEAFAAGRTVESYAYARTGYHRGLDALRRAGWKGHGPVPWEHEPNRGFLRALHALARAAGAIGEKDEYERCSTFLRDSSPTAADTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITC5</accession>
    <name>A0A0F4ITC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_36835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001329">
        <property type="protein sequence ID" value="KJY23926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001329.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1540"/>
    <dbReference type="EnsemblBacteria" id="KJY23926">
        <property type="protein sequence ID" value="KJY23926"/>
        <property type="gene ID" value="VR44_36835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4679"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY23926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="37178" checksum="4C1D855F260CFEC4" modified="2015-06-24" version="1">MSGHDGHDHGHDHEGGPGQAHAQASGHGHGHGHGHAGHSHGVDPDADRRWLAIALALIGGFMAVEVVVGVLAHSLALISDAAHMLTDAVSIVLALVAMRLAARPARGGFTFGLKRAEILSAQANGLTLLLLAVWLAYEAVRRLIDPPPVEGGLVLVTALAGIVVNVAAAWCISRANRSSLAVEGAYQHILNDLFAFIGTAVAGLIVLTTGFVQADAIASLVVVALMVKAGYGLVRESGRIFLEAAPAHLDPDAVGDRLVGHPPVTEVHDLHIWTITSGQAALSAHVLVEPAGDCHAVRRDLEALLAKEYGITHTTLQVDHVQDELLSVGRAGEGPETADPHCADAHGPVHRQGPHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITF4</accession>
    <name>A0A0F4ITF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001096">
        <property type="protein sequence ID" value="KJY25292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951287.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001096.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25292">
        <property type="protein sequence ID" value="KJY25292"/>
        <property type="gene ID" value="VR44_32875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3394"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15929" checksum="084D7A1EDC5F8CC8" modified="2015-06-24" version="1">MSVQEDNKQAVLGFFTAVNERRTADLPQYMAADVVDHNQIIHGEPDEPGAAFEGLRQQLAAFDPLTVRVEELVAEDDRVVARTVQSGTHGGSHPRMPEPTGRSFENEAIWWFTLDGGKISQIRGVSDRLGLFLQLGWDWPQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITT0</accession>
    <name>A0A0F4ITT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001152">
        <property type="protein sequence ID" value="KJY24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951507.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001152.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24893">
        <property type="protein sequence ID" value="KJY24893"/>
        <property type="gene ID" value="VR44_34055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3738"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="22583" checksum="E5016BCE5945A9B1" modified="2015-06-24" version="1">MAAGGVPVRAARKNAPPREDVLVAAMATIAERGLDGLTMAGLGRQVGMSSGHLLYYFRSKDELLLQTLEWSEAELGARRRSLLSRRESAGERLRAYVDLYVPDGARDPHWTLWLEVWNRSQNAGPAERDRQAAIEGAWHRDLVALLAEGISRGEFRTVDPDRFAARLRALLDGFSIQVAVGLPGIGREDILEHVREFLTQTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITX0</accession>
    <name>A0A0F4ITX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001147">
        <property type="protein sequence ID" value="KJY24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7089"/>
    <dbReference type="EnsemblBacteria" id="KJY24923">
        <property type="protein sequence ID" value="KJY24923"/>
        <property type="gene ID" value="VR44_33930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3712"/>
    <dbReference type="eggNOG" id="ENOG5032URV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8849" checksum="FE17E836CE9976E7" modified="2015-06-24" version="1" fragment="single">MRVYVPLTLPGLAEAHKAGELGPAPLTAYAVTPGLREWYVSDDIEELEYAALSRAAAASLRMLAEDAAAPRKRVVVAVDVADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUD1</accession>
    <name>A0A0F4IUD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">[Fe-S]-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001123">
        <property type="protein sequence ID" value="KJY25083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25083">
        <property type="protein sequence ID" value="KJY25083"/>
        <property type="gene ID" value="VR44_33460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3572"/>
    <dbReference type="eggNOG" id="COG2906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="52" mass="5149" checksum="6EB5017FE39B0FEE" modified="2015-06-24" version="1" fragment="single">VTKAGTDCGSCVRTIQGLLGRGACPRRELLEKGNAAGVLAADPAPAQLAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV53</accession>
    <name>A0A0F4IV53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001011">
        <property type="protein sequence ID" value="KJY25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950988.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000066_gene6667"/>
    <dbReference type="EnsemblBacteria" id="KJY25910">
        <property type="protein sequence ID" value="KJY25910"/>
        <property type="gene ID" value="VR44_31260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2739"/>
    <dbReference type="eggNOG" id="COG3653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="580" mass="62473" checksum="0DD29EAB888EE0AA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVS7</accession>
    <name>A0A0F4IVS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_34280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001168">
        <property type="protein sequence ID" value="KJY24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951548.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001168.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000049_gene3447"/>
    <dbReference type="EnsemblBacteria" id="KJY24796">
        <property type="protein sequence ID" value="KJY24796"/>
        <property type="gene ID" value="VR44_34280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3833"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="193"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34770" checksum="1A804DBDE343B0C4" modified="2015-06-24" version="1">MSNLDRQPALSSCGGRGFVVAEPVRELLSPRTVRLGESTEVRRLLPNLGRRMVGAWCFVDHYGPDDIADEPGMQVAPHPHAGLQTVSWLHEGEVLHRDSVGSLATIRPRELGLMTSGRGISHSEESPRPHARFLHGAQLWVALPDAHRDVAPHFQHHADLPRVTAPGLDATVILGTLDTATSPGAAYTPIVGADLALAAGTETRLPLDPDFEYAVLSMSGEAHVDGVPLLPGSMLYLGCGRTELPLRAASDAGLMLLGGEPFEEEIVMFWNWIGRSHEEIVQAREDWANGSRFGEVKGYDGPPIPAPEIPPTHLKPRGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWY9</accession>
    <name>A0A0F4IWY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000929">
        <property type="protein sequence ID" value="KJY26527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950733.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000929.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26527">
        <property type="protein sequence ID" value="KJY26527"/>
        <property type="gene ID" value="VR44_29840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2349"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26819" checksum="6C647BC27DAE830B" modified="2015-06-24" version="1">MRSAVVTPEGDRIRWVELPGEEPVRVYLHGLGATAPAYFAASAVHPRLAGRRSLLLDFLGHGHSDRPEAFPYTLEAHADTVAQALTAAGVAAAEVIAHSMGGAVAIVLADRHPDLVSRLVLVDANLDPLPPTPGTAGSSGISSYTEQEFLAGGWAEVRDRAGAHWWSTMRLAGRTALYRSAVHLAAGTTPTMRELLLELKVPRSFLHPEADGAPSGAGALEAAGVAVVPVPDCGHNIMLDNPEGFARAAAEALARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXM9</accession>
    <name>A0A0F4IXM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000903">
        <property type="protein sequence ID" value="KJY26795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26795">
        <property type="protein sequence ID" value="KJY26795"/>
        <property type="gene ID" value="VR44_29155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2175"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9648" checksum="C2920C021D68E08E" modified="2015-06-24" version="1">MDGLKWTGTDPNWFDTHPGKTARGFCGTCGSHLAARDHGNDMAIGILATALDHHHRPRPGPHQPEPARRSRPLAHGHRLSRLGGGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY88</accession>
    <name>A0A0F4IY88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000879">
        <property type="protein sequence ID" value="KJY26995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950507.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000879.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26995">
        <property type="protein sequence ID" value="KJY26995"/>
        <property type="gene ID" value="VR44_28615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11556" checksum="143EBAA8CA40ACF9" modified="2015-06-24" version="1">MEITTLALDGPQPDIPALCARVSEACREGPPRQLVCDASRAGRPTLATVEALARMALTARSHRTPFTVTGATPALRALLDLVGLVELLGEAEQGEPAGRVQEGVEADDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYZ9</accession>
    <name>A0A0F4IYZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001013">
        <property type="protein sequence ID" value="KJY25901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950998.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25901">
        <property type="protein sequence ID" value="KJY25901"/>
        <property type="gene ID" value="VR44_31320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2752"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27390" checksum="8799FEC1494E964E" modified="2015-06-24" version="1">MDRSIRSMEDVLSLLDGLFAPAADRWTAGGADWWDGFYADRAKPVPFFVAKPDENLAAHVERGLITPGRALDLGCGPGRNALHLASLGFEVDAVDLSPTALAWAGERAREAGADIRFHRGDAFALAAAGELGGPYDLVYDSGCFHHLPPHRRVSYLALLERVLAPGGHLGLTCFAAGAMGSELSDAAHYREGGLGGGLAYTPESLRWIFSGLEERELRRMRDEPQESPYFGEAFLWTALFRRPAGAPAPSAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J087</accession>
    <name>A0A0F4J087_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000952">
        <property type="protein sequence ID" value="KJY26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950811.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000952.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26336">
        <property type="protein sequence ID" value="KJY26336"/>
        <property type="gene ID" value="VR44_30270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2464"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1003" mass="107668" checksum="BAAAE110CB415C9F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J094</accession>
    <name>A0A0F4J094_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">VR44_27045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="JZWV01000807">
        <property type="protein sequence ID" value="KJY27690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950225.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000807.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5221"/>
    <dbReference type="EnsemblBacteria" id="KJY27690">
        <property type="protein sequence ID" value="KJY27690"/>
        <property type="gene ID" value="VR44_27045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1571"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21582" checksum="C0DE7DA31BB20123" modified="2015-06-24" version="1">MSRIGRVERTTKETSVLVEIDLDGTGKVDVSTGVGFYDHMLDQLGRHGLFDLTVKTDGDLHIDSHHTIEDTALALGAAFKQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHTEPENMAPMIGEYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYASEFDPRAAGILPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Q9</accession>
    <name>A0A0F4J0Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000832">
        <property type="protein sequence ID" value="KJY27454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950311.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000832.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27454">
        <property type="protein sequence ID" value="KJY27454"/>
        <property type="gene ID" value="VR44_27500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1668"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9166" checksum="F5094C36B07E2DB2" modified="2015-06-24" version="1">MFPSISLAQEIGLAVLLVAALVWVLGLGHMLWDSRFHHPEPDAYEGLPVIPSQRTAAGHPMESVELTQAEQEAFAGLVRTIPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J109</accession>
    <name>A0A0F4J109_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000835">
        <property type="protein sequence ID" value="KJY27423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27423">
        <property type="protein sequence ID" value="KJY27423"/>
        <property type="gene ID" value="VR44_27570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10566" checksum="7F5D3D207C002791" modified="2015-06-24" version="1" fragment="single">MIDAIAFKYRTGTPWMDLPEHFGSWKGAHNRLRMWAADGTWEKVFTALLAQADAEGDLEWVGAVDSTIVRAHQHAAGARQKGPRPASPPTTPSDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1B0</accession>
    <name>A0A0F4J1B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950648.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000909.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26711">
        <property type="protein sequence ID" value="KJY26711"/>
        <property type="gene ID" value="VR44_29385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2241"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046263">
        <property type="entry name" value="DUF6296"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19813">
        <property type="entry name" value="DUF6296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7854" checksum="083DF73FD9FA385E" modified="2015-06-24" version="1">MSTGRYELTFPGSAGTDGDTVVVDRTESTGPGGHPVYADATGIVRAEISDRGEVRMLATGGHQAPSQPVTARPVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1K9</accession>
    <name>A0A0F4J1K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione-dependent formaldehyde-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000903">
        <property type="protein sequence ID" value="KJY26801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950614.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000903.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26801">
        <property type="protein sequence ID" value="KJY26801"/>
        <property type="gene ID" value="VR44_29185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="3">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15122" checksum="312F188EEC74C048" modified="2015-06-24" version="1">MNATAAADAQGDEAAQERTGGCLCGRIRFTTEGPATFPHTCACRDCQKLGGTPVMWWVGFATVSWTGEGGEPTWYETFPGEAKRGFCSRVAAIDSDIPEIGINVTALDDTSGPDLVPIHASFRDNAVHWLPPVPETEHNTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J207</accession>
    <name>A0A0F4J207_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950171.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27773">
        <property type="protein sequence ID" value="KJY27773"/>
        <property type="gene ID" value="VR44_26755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1509"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="42"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="516" mass="52941" checksum="B937563289293C13" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2B0</accession>
    <name>A0A0F4J2B0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_25460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000735">
        <property type="protein sequence ID" value="KJY28405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949926.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000735.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene240"/>
    <dbReference type="EnsemblBacteria" id="KJY28405">
        <property type="protein sequence ID" value="KJY28405"/>
        <property type="gene ID" value="VR44_25460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1188"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="88"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY28405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="34721" checksum="F06AF882175D4B4F" modified="2015-06-24" version="1">MASSTPTRIETAPPVSKSGRSTGRAGDKIFSGLSKGSGILLLVIMASIAAFLTYRASIALSKNEGNFLTTFDWNASARPPVFGIAVLLFGTVVSSIIAMVIAVPIAVGIALFISHYAPRKLAAPLAYVVDLLAAVPSIIYGIWGALFLVPQLNGLNLWLDQYLGWTYVFDKTQVGVARSLFTVGVLLAIMILPIVTSVSREVFLQVPRMNEEAALALGATRWEVIRLSVLPFGRSGVISASMLGLGRALGETMAVATVLSPSFLISGHILDPGGGTFAQNIAAKFDEANEFGRDALIASGLVLFLLTLLVNGAARLIIARRKDFSGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2F0</accession>
    <name>A0A0F4J2F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ald_Xan_dh_C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000732">
        <property type="protein sequence ID" value="KJY28430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28430">
        <property type="protein sequence ID" value="KJY28430"/>
        <property type="gene ID" value="VR44_25380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11374" checksum="6496CCB3A6D8CA27" modified="2015-06-24" version="1" fragment="single">DGTVRFRLPREEVGQGLTTAVAMLVAEELDAPLDRVRVELDDARPELLFNQLTGSSNSIRSLYGPVRQCAATARARLVAAAAARWDLPAASLTTAGGSVRAPDGRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2Q6</accession>
    <name>A0A0F4J2Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000855">
        <property type="protein sequence ID" value="KJY27246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950403.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000855.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27246">
        <property type="protein sequence ID" value="KJY27246"/>
        <property type="gene ID" value="VR44_28035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1820"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="415" mass="41593" checksum="6BAADFE2A43E0803" modified="2015-06-24" version="1">MTESFRREGEYPQENRPAPHSPFGEDWQRGRDRLAQDAMGGGGSYPPPPAYPPAAPGWNEAHQPPAATVIQGETVTAGDGNGGGHNGHNGWTTWGDAAPPPAPRAKRPVALLAAVALAAAVVGGGTAAAVQQFLGQNGTNGPGFPGTNVSQSSNGTVSGVAEQVSPSVVRIDTRTASGTGTGSGIVITADGEIVTNNHVVNGASEIQVTMSDGKKYTARTVGTDPDKDLALIKLQGASGLKPAKLGNSDHLKVGDQVVAIGSPDRLTGTVTSGIVSALDREVNVPKSEGQQQRGRQGGGGGGWPFSYDGWQFNGDTGSNTTSYKAIQTDASLNPGNSGGALVNMNGEIVGMPSAIFSPSNDSSSAGSVGLGFAIPVNTVKADLANLRKGGSGSGGASDGSGNGNGNGFGISLGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J301</accession>
    <name>A0A0F4J301_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_27915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000849">
        <property type="protein sequence ID" value="KJY27316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950382.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000849.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27316">
        <property type="protein sequence ID" value="KJY27316"/>
        <property type="gene ID" value="VR44_27915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1832"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="11379" checksum="6AC14DE20522C13D" modified="2015-06-24" version="1">MSTTATVVTLVAAFMAGFSGLSIFRGAKFVTEPLVEYGVPKGMWTFLATAKVAGALGLLVGFAVPAIGTAAAIGLVLYFTGAVITVLRARSYAHVAFPLIYAAPAAAVLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J445</accession>
    <name>A0A0F4J445_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000716">
        <property type="protein sequence ID" value="KJY28584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949843.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000716.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28584">
        <property type="protein sequence ID" value="KJY28584"/>
        <property type="gene ID" value="VR44_25010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1092"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="32454" checksum="62656283E51651FB" modified="2015-06-24" version="1" fragment="single">GEYDFTGAGAEFTPDAASALRAACAAADVVHAHGVRAGMRAALALRGRGRRAPLVVTWHGTAPDTGPLGRLGRLLERHVARAAAVVLGSSSDQVDLARRRGARDARLAAVAVPAAPAPPDTGKTRAELGAVERPLVIAIGSLVARRGYSFLLDAARAWRDLEPAPLLLIAGEGPLRPELARRIETENLPVRLLGRRRDADRLLAAADVAVLPSRWEGRSLLAQEALRAGVALVATEVGGVPELVGDAAVLVPYGDTEALAAAVAALLHDPARRAALSTAGRAQAATWPSEDDTVAQILSVYDELMERRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4B2</accession>
    <name>A0A0F4J4B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29110">
        <property type="protein sequence ID" value="KJY29110"/>
        <property type="gene ID" value="VR44_23710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.688"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="26461" checksum="ADCEF0E79A76EB68" modified="2015-06-24" version="1">MSGSEATPPSTSGPQELAVLALTRESERARRMLAAGEWRPDAADTDAAARVLARLTAPLPTRRAGSARARAVDRDRRLQRIWRSAVHHLDAGAVSAPAAALLAAVARALLPWFAVPNPPSAAAAPHYPLPRGTGEGFPAAPTEAGEALLPDMTDLFAALSAPHPPGTVPRTPAAAPWQTRYAGRFRHYGRPAHDVWTADTFRCSGCGNADGPWSVTCDWRRVTLGCPCGQETDRHGLSFSEVFLVLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4L7</accession>
    <name>A0A0F4J4L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000788">
        <property type="protein sequence ID" value="KJY27881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950129.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000788.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27881">
        <property type="protein sequence ID" value="KJY27881"/>
        <property type="gene ID" value="VR44_26540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1432"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="1">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="499" mass="53391" checksum="FBC0A7F658935F0C" modified="2015-06-24" version="1">MYGGPSHNGSLSPPLYLEPRLAPRTAALLESPAFLHTLVDALGSPLNVILPDQIADNVRGFREVFDRHRLSGRIFFAHKANRSSALVRRLTTTGAALDAASLGELRHALGSGFAGAEVMATGPKDPEFLWLAARSGALLNADGPGELERAAALVRAHGLPRLRVLLRLSGFEAPGARRLSRRSRFGTSVKSLHRLLDVLDRHRGELEAVGVGYHLDTTSVEEKASALEGCLHAMEELQVRGHRPRAVDVGGGFGVGYLAHAAQWERYTTELTRAVMGARPPLTWGGHGYGLRAENGTLRGALGLYPAHRSTAGPGYLDELLSLPAPRLGRPLGTLLLEGLYELYAEPGRALADQCGLTLGRVLEVRASGTGETLVRLALNAGDVSLEDHGVLVDPVLLPRAPAPPGGAAPVAAHLMGNLCLEADLITRRTVFLPRLPHPGDLLAFVNTAGYCMDFGATRAQGQALARKVAVHREGADGDWQWCLDEQYWPLTRTGEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4P7</accession>
    <name>A0A0F4J4P7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_24775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28703">
        <property type="protein sequence ID" value="KJY28703"/>
        <property type="gene ID" value="VR44_24775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.956"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470728" description="Histidine kinase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="196"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="273"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="507" mass="53084" checksum="0517B4D85793B851" modified="2015-06-24" version="1">MPRRRPLSLRTRLVVSAVVLIAVVGAAIGTVTTLTMRSRLMGELDKQLDNSVRMAVRGPGAGKAAREGSLGFIFAPGSPMGAAGIRLDVDRKVIGGARIAPVEGPGLDHREVLTQAQTAVLERVARTAGPGGSGGMDVDLPGLGAYRAMAAPDGALVLAFPVKGVDSTVNTLIAVEVCVTLAGLIAASLAGQALVAVALRPLRRVAATATRVSELPLHSGEPALHERVPDAEADPRTEVGQVGAALNRMLGHVSSALTARQQSETQVRQFVADASHELRTPLASIRGYAELTRRGREEPGPDTRHALARIEAEATRMTGLVEDLLLLARLDAGRPLSREDTDLAPLVVDAVSDARAAGPGHHWRLALPEEPAPVLADPARIQQVLVNLLANARTHTPPGTTVTAGVSRETSAVRVRIEDDGPGIPPELMPHVFERFARGDASRSRAAGSTGLGLAIVQAVVTAHGGRVDVESEPGRTCFEVLLPLAPEPGPMAPTDSQRDHRVSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4R8</accession>
    <name>A0A0F4J4R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">VR44_24540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949756.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28804">
        <property type="protein sequence ID" value="KJY28804"/>
        <property type="gene ID" value="VR44_24540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.903"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13507" checksum="FC658C15B937839C" modified="2015-06-24" version="1">MSNPQQLRYTKEHEWLSDAVDGVATVGITAFAADALGDVVYAQLPEVGDTVTEGETCGELESTKSVSDLYSPVSGEIVEFNQDVVDDPALVNSAPFEGGWLFKVKLSEEPKDALSFDEYTALTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J562</accession>
    <name>A0A0F4J562_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000768">
        <property type="protein sequence ID" value="KJY28046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950066.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000768.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28046">
        <property type="protein sequence ID" value="KJY28046"/>
        <property type="gene ID" value="VR44_26205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1397"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14663" checksum="792382745A0B3F2A" modified="2015-06-24" version="1">MLTNLMYVTLYVTDQDRALRFYTEQLGLEKRIDYPGPDGRFLTVAAPGSPVEIILWVHGAAAGQPAEVQAGGTPGPVILESDDLREDFKVFRDRGVRFDGEEPEEYGFGLRVEALDPDGNRISLRQRPGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5A7</accession>
    <name>A0A0F4J5A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000684">
        <property type="protein sequence ID" value="KJY29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949650.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000684.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29014">
        <property type="protein sequence ID" value="KJY29014"/>
        <property type="gene ID" value="VR44_23945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.764"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29578" checksum="F307BE2FC754A4B1" modified="2015-06-24" version="1">MAAPARFSLNQETVRQWSLPELVAGCCAAGVAAVGLWREPVRGFGVRETARLVASAGLRVSSLCRGGFFTASDPAGRAAALEENRRAVEEAAELGADVLVLVSGGLPEGERDLAEARRRIAGFLGDLVPWATGHGVRLGIEPLHPMFAADRCVVSTLGQALDIAEQFPAEQVGVVADSYHLWWDERLAADLGRAGAGGRIVSVQVADWVTPLPEGVLLGRGQLGDGCVDLRAFRQLADRAGYRGPVEVEIFHPGLWARDGTEVLREVIARYREHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5E3</accession>
    <name>A0A0F4J5E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29572">
        <property type="protein sequence ID" value="KJY29572"/>
        <property type="gene ID" value="VR44_22590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.409"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025323">
        <property type="entry name" value="DUF4229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14012">
        <property type="entry name" value="DUF4229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10846" checksum="798E3BEB9E1B07E1" modified="2015-06-24" version="1">MVSLKPSATIRYTAMRLGIFVGCLVLVAVLVHFGLVPSGLGSANPAWIVLLALVLSAPLSFVLLRKQRDEMSQQISGRVADAKQKLAANRSQEDAADDAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5J3</accession>
    <name>A0A0F4J5J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome replication initiation inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000753">
        <property type="protein sequence ID" value="KJY28196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950008.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000753.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28196">
        <property type="protein sequence ID" value="KJY28196"/>
        <property type="gene ID" value="VR44_25905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1286"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017685">
        <property type="entry name" value="ArgP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03298">
        <property type="entry name" value="argP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="31515" checksum="64B0D819F19E0AD0" modified="2015-06-24" version="1">MDELPLDQVRTLLAVVDEGTFDAAAAALHVTPSAVSQRVKALEQRTGRVLLMRSKPVRATESGEVVVRFARQLARLERDARAELGMGTADGQGPVRLPIAVNADSLATWFLPVLSRVPQDPPVCFELYREDESHTTALLREGQVMAAVTSSPDPVAGCTVRALGLARYLPVAAPGFAARHLAGEPAADLRTAPTIVFDRRDDLQDSFVRSLTGDGTGASPVRHRVPTSEGFRDAVASGLGWGLVPEAQAGPLLRAGALVRKLDSPALAAVARLVAETARGALLPPGRPGSGGPGAGDRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5K7</accession>
    <name>A0A0F4J5K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_23870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949631.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000681.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1358"/>
    <dbReference type="EnsemblBacteria" id="KJY29048">
        <property type="protein sequence ID" value="KJY29048"/>
        <property type="gene ID" value="VR44_23870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.747"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="31020" checksum="BEFD9026363B32B5" modified="2015-06-24" version="1">MSAVRASAPAEETAPGYETAPGYRPGRTLPLRVEALRQWRRRRTLVMGGVLAALPFVMIIAFAVGGSDDGRGGSDGRVSFIDTATASGANFAATCLFVSAGFLLVVPVALFCGDTVASEASWSSLRYLLASPVPRARLLWSKLVVALGFSLAAIVLLPVVALAAGTAAYGWGPLKLPAGGALPAGDTVARLALAVAFVFVSQLVTAGLAFWLSTRTDAPLGAVGGAVGLTIVGNVLDAVTALGSWREFLPAHWQFAWVDALQPQLEWGGMAKGAVVSVSYALVLFALAFRGFSRKDIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5L3</accession>
    <name>A0A0F4J5L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949361.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29652">
        <property type="protein sequence ID" value="KJY29652"/>
        <property type="gene ID" value="VR44_22400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.369"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="14984" checksum="310141FF55213B73" modified="2015-06-24" version="1">MSRTTTRTAVSPLTTEDAELLLTAARAAAEAAGVAVSVTVLDAGGHLLAFRRDDRAVLISGETSTRKAYTALQLNAPTAALTEAVLPGGPFHSLPTALDRPLLFIAGGLPVHRDGHLIGAVGIGGGAPEQDHGFGEAALEALGRAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5M0</accession>
    <name>A0A0F4J5M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000640">
        <property type="protein sequence ID" value="KJY29485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29485">
        <property type="protein sequence ID" value="KJY29485"/>
        <property type="gene ID" value="VR44_22845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.502"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="27177" checksum="6B95239224152895" modified="2015-06-24" version="1">MFLAAGCSSSGDSGPGEAAGGVPVVHQGKLTTCTHLPYPPFQFEQNGKVVGFDVALIDLVAQNLKVEQKILDTPFENFKTGAFLNSGQCDLAAAGMTITDERKKNVDFSIPYFDATQALLATKKSGITSLDDVKAKSARLGAQAGTTGESYAKSQGFNPVAFESSDAVLNGLRTGQVDAVVIDYPVVQGWLKDKANSDQFVLGTKAIETGEKYGFSVKKGNSALLAAIDKAITTAKADGTYNKLYEQWIGPLPQVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J677</accession>
    <name>A0A0F4J677_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_23345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949533.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene119"/>
    <dbReference type="EnsemblBacteria" id="KJY29273">
        <property type="protein sequence ID" value="KJY29273"/>
        <property type="gene ID" value="VR44_23345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.609"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="21329" checksum="CF0A1DC958AF8F26" modified="2015-06-24" version="1">MAHGDVLEFEEYVRTRQDALLRSARRLVPDPTDAQDLLQTALVRTYGRWDGIADKSLADAYLRRVMINTRTEWWRARKLDEVPTEQLPDASIEDGSDQRADRALLMDILKVLAPKQRSVVVLRHWEQMSTEETAAALGMSAGTVKSTLHRALARLRQELESRDLDMRALERGDHTTRYEGRERCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6J8</accession>
    <name>A0A0F4J6J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000611">
        <property type="protein sequence ID" value="KJY29835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949276.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000611.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29835">
        <property type="protein sequence ID" value="KJY29835"/>
        <property type="gene ID" value="VR44_21920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.264"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="176"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="33646" checksum="C3BB9D824B4DE533" modified="2015-06-24" version="1">MSNGQGSRGSGGASGGAGGGPVIAAVDGSDHSLSALEWAREAALRHGTALMVAHVLPDASQLYAGRRSALHDPNEPKEYADPVGDRVRALLESGPELPAEVRYEALEGSVPEALRAVSAEQAPLMLVMGSRGRGGFAALLLGSSSRAVAGTASCPVVVVPHEGRAAEDPEGASAGRVVLGLHAAETPEDVLAFAFAEAAARGTTVQVVSAYALPPGPMTVIDSPFAVIPPEALADGADGVPAERETLRAQNERLAPLRARYPDVPVEQAVVPGDPAGRLVEASRSAALVVVGRHHPRRRSLLIGSVAHALLQHAHGPVAVVPTLHDDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6K3</accession>
    <name>A0A0F4J6K3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29413">
        <property type="protein sequence ID" value="KJY29413"/>
        <property type="gene ID" value="VR44_23040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="2">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="19659" checksum="1E3D54E2E9D125B6" modified="2015-06-24" version="1">MGGVSKELSAPRGRSLVRRRGTPDEEAATAGRAQPGEDQQPPREAPNTSATPPEPHTRRRTHKHSRRSKVCSVRMDDDEHALVATAAKAVGVTVAGFFAKAALKEAHDPHTSAAAIAGRRETVIKLFTARRHLAQIGNNLNQLTRAVNSGGRPTDIQLDAVLDSVRRASARVQDATDQLLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L8</accession>
    <name>A0A0F4J6L8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949462.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29464">
        <property type="protein sequence ID" value="KJY29464"/>
        <property type="gene ID" value="VR44_22870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.508"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="39161" checksum="A2CC61D20EB587CC" modified="2015-06-24" version="1">MTVGAEEEYLLVDPVTRELRPEAPKVVAEAAVELGDRVTTEITGYQVEVRTDPHSGLGRFAEQVRSMRAAVVRAAARHGLGVISSGTPVLPQPLPPPLTEGDRYARSAAEFGALDDEQSICACHLHIGIPDLETALQVSNHLRPRLPALIALAANSPFWQGRDTGYTSWRTLAWARWPAAGPPPYLTSRTHFEGLVSGLTATGGIMDRGGLYWDIRPSHHAPTIEIRVADAMATAQDTVLLAAVVRALVDTALTDIEAGRPAFRPDPEMLRAACWRAARDGLGGQAVDLRGHRLVPATTLVEELLADLRPALRRHGDLETAGAGWSVLRTAGGGADRQRAAHRDRGGPAGVVDYLMHAMTAPDAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6P7</accession>
    <name>A0A0F4J6P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949237.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene134"/>
    <dbReference type="EnsemblBacteria" id="KJY29890">
        <property type="protein sequence ID" value="KJY29890"/>
        <property type="gene ID" value="VR44_21720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.224"/>
    <dbReference type="eggNOG" id="COG5495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="145"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="31825" checksum="0E9B065A97CD7DBD" modified="2015-06-24" version="1">MNSSQQERPARLSVGVVGAGRVGPALARALQQAGHHPVAVSGVSDASRRRADRMLPGVPLLTPAQVLERAELVLLTVPDDALPGLVEGLAETGAVRPGQLLVHTSGRYGTAVLDPARRAGALPLALHPAMTFTGTEVDVQRLAGCSFGVTAPDELRLAAEALVIEMGGEPEWIAEESRPLYHAALALGANHLVTLVAQAMELLRTAGVEHPDRMLGPLLGAALDNALRSGDAALTGPVARGDAGTVAAHVSELREHAPGTVAGYLAMARATADRALAHGLLKPELAEDLLGVLADTADTADTDPKGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7C7</accession>
    <name>A0A0F4J7C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000622">
        <property type="protein sequence ID" value="KJY29714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29714">
        <property type="protein sequence ID" value="KJY29714"/>
        <property type="gene ID" value="VR44_22210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.327"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="21467" checksum="B4DB460F16968BAB" modified="2015-06-24" version="1" fragment="single">MAAGAPNGAGGQARNPGGLRASLSGLTTRGRSFLAAGAAAAVCAYVLGQGQLLRVGLLLVVLPLICVVALHRTRQQVTAGRRLTPPRVPAGGEARVQLRLENVSRMPTGLLMLQDRVPYVLGPRPRFVLDRVEPGGRREVSYRVRSDLRGRYPLGPLQLRLTDPFGMVELTRSFSAYDTLTVVPRTQPLPAVRMTGEAGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J893</accession>
    <name>A0A0F4J893_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000599">
        <property type="protein sequence ID" value="KJY30009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949174.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000599.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30009">
        <property type="protein sequence ID" value="KJY30009"/>
        <property type="gene ID" value="VR44_21400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.156"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="26062" checksum="4CFE4F8749ED2F4A" modified="2015-06-24" version="1">MYAVILAGGKGVRLRPYTTALPKPLVPIGDQHAILEIVLRQLSTAGFTRCTIAIGHLGEIIRAYVGDGSQWGMSVDYATEESPLGTMGPLLNLRDRLPEHFLVMNGDVLTDLDYADVLRRHEASGAPLTIATYPRKVHIDFGVLTTDASRVVGFTEKPSMDYHVSMGVYGLSRSTLDNYTPGLPLGFDELVLDLLDSQNLPQSYAFDGYWLDIGRPDDYDRANAEFTTRKSLLLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J905</accession>
    <name>A0A0F4J905_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948797.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000530.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3573"/>
    <dbReference type="EnsemblBacteria" id="KJY30867">
        <property type="protein sequence ID" value="KJY30867"/>
        <property type="gene ID" value="VR44_19335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8474"/>
    <dbReference type="eggNOG" id="ENOG5031BTP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24492" checksum="D3CD10EF37A1F543" modified="2015-06-24" version="1">MTDGFPAPVAVANAPLAATVTRVAELANKMGRDPNQVFDLRRLSEASGVPTDVIRSLLDGRRAGEPDLQARFLQRLDLLRRTRVKPNGRRYTQQEIADGAGMSRQQAGALINGDRRPTMEHCDAIQRFFGVHAGFLTAHDADALTDALQRTEQQLLQDFAGRERQTVPAEAATAGDPLARLLQNHGVRGIAWRAAQLPSDKHRDKVTEWLDMLLESVKPNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J921</accession>
    <name>A0A0F4J921_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">VR44_19855</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948890.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3107"/>
    <dbReference type="EnsemblBacteria" id="KJY30685">
        <property type="protein sequence ID" value="KJY30685"/>
        <property type="gene ID" value="VR44_19855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8590"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="158"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY30685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="480" mass="52116" checksum="9567AE909BB4E5C1" modified="2015-06-24" version="1">MTTSVETAAATGRIARVIGPVVDVEFPVDAMPDIYNALTVQVADPAEEGALKTLTLEVAQHLGDGLVRTISMQPTDGLVRQAPVTDTGSGITVPVGDFTKGKVFNTLGEVLNYPEANSEVTERWAIHRKAPNFDELESKTEMFETGVKVIDLLTPYVKGGKIGLFGGAGVGKTVLIQEMIYRVANNHDGVSVFAGVGERTREGNDLIEEMSDSGVLDKTALVFGQMDEPPGTRLRVALAGLTMAEYFRDVQKQDVLFFIDNIFRYTQAGSEVSTLLGRMPSAVGYQPNLADEMGLLQERITSTRGHSITSMQAIYVPADDLTDPAPATTFAHLDATTVLSRPISEKGIYPAVDPLDSTSRILDPRYIAADHYNAAMRVKGILQKYKDLQDIIAILGIDELGEEDKLVVHRARRVERFLSQNTHVAKQFTGVDGSDVPLDESIAAFNAICDGEYDHFPEQAFFMCGGIEDLKANAKELGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9P4</accession>
    <name>A0A0F4J9P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948965.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30519">
        <property type="protein sequence ID" value="KJY30519"/>
        <property type="gene ID" value="VR44_20265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8761"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24041" checksum="8DB557ACEF98EBC2" modified="2015-06-24" version="1">MSLLLAPWTRLSLLVVLLVAAGVCVLVYEPQRMLSQGWPTGLPVGVAVLLFGGAYGLCTAAFVPRPLLNLAAGAVFGAQAGLVAAVGGTVLGAGISFGLGRVMGQEALRPLLRGRWLKAADAQLSGHGFRSVLAVRIFPGVPFAAANYLAAVSRCGWLPFLLATALGTVPNTTAYVIAGASASSPGSPAFLVSFGFITVSGAVAAAVAWRGRHRLAGPAAHEPSPVHPPVVGAAPHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAC0</accession>
    <name>A0A0F4JAC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042809536.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000515.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31135">
        <property type="protein sequence ID" value="KJY31135"/>
        <property type="gene ID" value="VR44_18835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8378"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="11021" checksum="033B853B0EE33EB9" modified="2015-06-24" version="1">MATDYDTPRKTDDDVDNDSIEELKARRSDKVTSSVDIEDFDGAESLELPGADLSNEELAVRVLPKQADEFTCMSCFLVHHRSQLAREKDGQPICRDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB49</accession>
    <name>A0A0F4JB49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000523">
        <property type="protein sequence ID" value="KJY31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948750.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000523.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31024">
        <property type="protein sequence ID" value="KJY31024"/>
        <property type="gene ID" value="VR44_19085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8421"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="328" mass="36337" checksum="382EF0103EA04F05" modified="2015-06-24" version="1">MLKLSVVVPFYNVQTYAPDALRSLELNAREDFEFLLVDDRSTDGTPGLLERAAAALPGAVLLRRERNGGLATARNTGLDAARGRYIAFLDGDDWLAPGHLARTLAAIEALNCDFVRTDHVQVTGRERVVQRVPYGPESVVADPRAGILPASRATAVDYPYAWAGMYHRRLLDRGLLHFTDGLRTAEDRPWIWRLHREAESFATVGLPGVFYRRGISTSLTQIGDERQLDFIRAFDQVLSDTAADRESELLIPKAVRTYCAIIAHHIGSIERFEPAVAKKLRSMSADALARMPRAALERALDTMDSERSALLRRLRRRSASVTASGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC15</accession>
    <name>A0A0F4JC15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000471">
        <property type="protein sequence ID" value="KJY31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31745">
        <property type="protein sequence ID" value="KJY31745"/>
        <property type="gene ID" value="VR44_17590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9171" checksum="78B23FB59D075636" modified="2015-06-24" version="1" fragment="single">AGIPERMFAAYLTGAAQVTTYVPGCRGMRWQVLAGIARVESDHAAGHTVAAGGDISPIITGPRLDGSGAGGNTTAIGDTDGGRWDNDPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCG4</accession>
    <name>A0A0F4JCG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948341.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32037">
        <property type="protein sequence ID" value="KJY32037"/>
        <property type="gene ID" value="VR44_16895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7815"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21280" checksum="601A46D10E32D845" modified="2015-06-24" version="1">MVSGLTLLHTSPVHVPVFDALRDERHPGAVLRHLVVPELLDRARELGPAAVAGQVREVLEGVGGPVLVTCSTVGAVAESLGPGLGVPVLRVDRPMAAEAVRRGPRIVVLAALASTLGPTGELLAEEAGGLPVTVRGRVVAGAWERFEAGDTEGYLEAVARAADAVEEADVIVLAQASMAGAARLTRTGLPVLSSPAPGLAAALLRGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD44</accession>
    <name>A0A0F4JD44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948280.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32120">
        <property type="protein sequence ID" value="KJY32120"/>
        <property type="gene ID" value="VR44_16595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7751"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21604" checksum="129BDA719427007E" modified="2015-06-24" version="1">MDGTLVDTEVLWWQTTEEVADRLGHRLGPADAPEVVGRAVADTAAHLVRVTGGADAEAVADELTGGFFGRVAAGAPVRPGAQRLLTALEAQGVPFALVSASPRVVVDQVVGGALAHVPFAFTLSADDTVRTKPHPEPYRAAAELLGLEPGECVAVEDSPDGAASAEAAGCPVLVVPSMLDVPRSAARTFASSLEEVTPELLRGLRRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEY0</accession>
    <name>A0A0F4JEY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32907">
        <property type="protein sequence ID" value="KJY32907"/>
        <property type="gene ID" value="VR44_15030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7425"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14590" checksum="7B59EE50D55A498F" modified="2015-06-24" version="1">MGSALRSQLESAGISAECASTIELVRDVLARVGDRWTVLVVTTLAGGPLRFSALHGRVAGVSQRMLSQTLRALTRDGLVARTAYAEVPPRVEYELTPLGRSLSDAVAHLTHWVRDHQAEIARNREEFDGGDSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF12</accession>
    <name>A0A0F4JF12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948183.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32404">
        <property type="protein sequence ID" value="KJY32404"/>
        <property type="gene ID" value="VR44_16100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7643"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25720" checksum="63B2B3B545DA20F6" modified="2015-06-24" version="1">MHRITTGRAAPIPPRWAVAAGVGAALAAAWWLGDKAPYPYAQRGLLDVPLPFLTADRMDAVLQPRPGERILEIGPGTGLQSLHVAPQLGPAGRLDVLDIQQEMLDQVMCRAERDGLATIRPTRSDARELPYADETFDAVYAVTALGEIPEPDRVLREAVRVLAPGGRLVIGEFFDRHWIPFGRLHRLADAAGLHLTERRGPSPAYLARFRPCTADAPGHQSERLAHSDRDTNGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFL3</accession>
    <name>A0A0F4JFL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947938.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000378.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32980">
        <property type="protein sequence ID" value="KJY32980"/>
        <property type="gene ID" value="VR44_14755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7347"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16065" checksum="D8BD12D30DFE6A8B" modified="2015-06-24" version="1">MTDRSLTLAEVEALARSAHEGQTDKAGRPYAEHLAAVAEGVRLRGGSPAQQAASWLHDSVEDDALSPGQLAEAALPQEVKDMVLALTKRPGEPLEEYTARILATPGAVLVKEADLAHNADPVRLSVLDAPTRDRLTAKYARVRSLLGITAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFP3</accession>
    <name>A0A0F4JFP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948434.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5592"/>
    <dbReference type="EnsemblBacteria" id="KJY31806">
        <property type="protein sequence ID" value="KJY31806"/>
        <property type="gene ID" value="VR44_17435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8024"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="315" mass="33681" checksum="39D1BB486B62577C" modified="2015-06-24" version="1">MAVSSRGQKQPTLAQLRAFAAVAEHLHFRDAAAAIGMSQPALSGAVSALEEALGVQLLERTTRKVLLSPAGERIAVRARGVLDAVGGLLEEAEAVRAPFTGVLRLGVIPTVAPYLLPTVLGLFHRRYPRMDLQVHEEQTASLLEGLAAGRLDLLLLAVPLGVPGVCELPLFDEDFVLLAPREHPLAGRRDIPREELRGLQLLLLDEGHCLRDQALDICREAGRTAGADVTTTAAGLSTLVQLVAGGLGVTLLPRTALRLETARNEALATGYFAEPAPSRRIALAMRTGTARQEEFRAIAAALREAVRPLPVWPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG42</accession>
    <name>A0A0F4JG42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">VR44_17130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948377.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3062"/>
    <dbReference type="EnsemblBacteria" id="KJY31921">
        <property type="protein sequence ID" value="KJY31921"/>
        <property type="gene ID" value="VR44_17130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7958"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="42255" checksum="AB154887DEAF0E0A" modified="2015-06-24" version="1">MTATRVLVLNSGSSSVKYQLLDMADSSRLAVGLVERIGEEGSRLVHEPLAGPGAAGGRRERTGAIADHAQALRAVAEELAADGLGLDSPELAAVGHRVVHGGTRFTAPTVIDDEVLAEIRSLIPLAPLHNPANVTGIEVARELRADLPQVAVFDTAFHSTMPEHVARYAIDAATAEKYSIRRYGFHGTSHAYVSRATAALLGKAVEDVNVIVLHLGNGASASAVRGGVCVETSMGLTPLEGLVMGTRSGDLDPAVIFHLARVGGLSVDEIDSLLNKKSGLLGLCGDNDMREVTRRAEAGDESARLALAAYVHRLKKYIGAYTAVLGRVDAVVFTAGVGGNAAVVREAAVSGLEELGLALDLEANAVRSPEPRLISTDYARVAVAVVPTDEELEIATQAYALVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHN5</accession>
    <name>A0A0F4JHN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000331">
        <property type="protein sequence ID" value="KJY33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947633.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000331.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33862">
        <property type="protein sequence ID" value="KJY33862"/>
        <property type="gene ID" value="VR44_13065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6732"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7967" checksum="6500D160C7020876" modified="2015-06-24" version="1">MDEQGGAGGVPLHGDDDPQRQRKPHPERSASGPSRPAEAPGPVRREDTDEASRLDRPAPPDPEPPPRRGGHGGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI84</accession>
    <name>A0A0F4JI84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_13900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947786.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6078"/>
    <dbReference type="EnsemblBacteria" id="KJY33468">
        <property type="protein sequence ID" value="KJY33468"/>
        <property type="gene ID" value="VR44_13900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7066"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01153">
        <property type="entry name" value="ACAD_fadE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034188">
        <property type="entry name" value="FadE5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="473"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="608" mass="66227" checksum="6C26C2145719F4D1" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKV3</accession>
    <name>A0A0F4JKV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hexulose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_11910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000289">
        <property type="protein sequence ID" value="KJY34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947418.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000289.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34434">
        <property type="protein sequence ID" value="KJY34434"/>
        <property type="gene ID" value="VR44_11910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6388"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047989">
        <property type="term" value="F:hydroxybutyrate-dimer hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016582">
        <property type="entry name" value="OHBut_olig_hydro_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10605">
        <property type="entry name" value="3HBOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470618" evidence="7">
        <location>
            <begin position="37"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="51112" checksum="ADEF6BB0AD5A3BB9" modified="2015-06-24" version="1">MRLSVPPRRGPRPGLLRRAAAAAAVLVTVAAVPAAAERNGGAAPADGHCSGMSRLRVPGAELGVPSCLDELTTAGTVASGHTDRADWAGLTPAGLSVPSGVPGIQIDGYFPDSSTGNTNHGWNHDSQFVIRLPDRWNGGLVVTGSPGVREQYANDRAIGDWVLARGYAFAATDKGNTGIAFHRDGRAPGDAIAEWNGRVTQLTRAARAVVAQRYLRPPSRTLATGMSNGGYLVRWQLENHPELYDGGVDWEGTLWREQGPNLLTFLPPALAAYPRYAAGGAGAEQARREMAAAGFPAGSEFLWPFHHQYYWDVTQRIYREELDPGYDGPQEAGTPFCLPGTPACDADYDYGLRPRSVHDAVAKIALTGRIGKPLITLHGTLDVLLPIGRDSDVYARMVDDAGRGRLLRYYRIEGGTHVDSLFDAFPDRLRPLVPCHRSALTALEDWLGRGTPPPASRTVPRPAAGEDPLTNCRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLB9</accession>
    <name>A0A0F4JLB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000340">
        <property type="protein sequence ID" value="KJY33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33766">
        <property type="protein sequence ID" value="KJY33766"/>
        <property type="gene ID" value="VR44_13340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6904"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24306" checksum="5947862B18F9E3BE" modified="2015-06-24" version="1" fragment="single">LAFWVPASGSSAPGGGRPDTARYDRAARALDDVRREVEAVLTVRQDAEARLIALRDVLSRADRTLSEARTARGEVLAKIAASEVPAVSGPPTALQEQLAAAAEYRRQSQWHRLSPLLDALEDRAEEELRRARESLTAVTAPLAVRAELRGRLDAYRAKVARHGMAEDPLLVERYDTARRMLWSAPCDLRAAEGAVLRYQRAAAEALAPPEDHRPEGTGEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JME4</accession>
    <name>A0A0F4JME4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947113.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35385">
        <property type="protein sequence ID" value="KJY35385"/>
        <property type="gene ID" value="VR44_10295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="28173" checksum="C73002ED5AD07478" modified="2015-06-24" version="1" fragment="single">MGGADHGPVARTRIAALTGLSPAAVSRQVVDLTGLGLVRERPELVAAAGVGRPQVPVDIDCGRVAVAGVHIGVPGATLSLIDLRGRVLAREDVSSREPGPDGILGRVAGRLPAFLAAHRGGLTLAGVGAVLGGRVDPERGIAVRHEPLGWYEVPLRDALERVTGLPVYVDNHARALAQSEILFGHPDAQHSIVAVFVGHVVDAALGSGGRVHLGPRAATSDIAHQPVPGSRAKCSCGRTGCFEAVVSDTVLFAEAARRGIIAEPDRTLLSEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMI3</accession>
    <name>A0A0F4JMI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947267.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34958">
        <property type="protein sequence ID" value="KJY34958"/>
        <property type="gene ID" value="VR44_11100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6104"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="40791" checksum="26EE8BD406276286" modified="2015-06-24" version="1">MELGFLKPLFARPGPWASVYVETTRATEDAQRIQALREREVASRLIDAGADAYTVRAVVNRLANEPVSGAPPGRALFAAGAEVVLDIPLGKVPAAIEATWSVLPHIAPLAGLRGDDPSCLVAYIDRTGADLELRHAYGRAAVGQARGKEWQDRGHRGVPADRHEWHYRNKDENARNETADVIAAELARMWPESGAGLVVLTGDARERRAVHNRLPERMRAVTAEVDGGRTPGASQDTLDREIARLREGFARRRLESALERFRIGRGRPGEHRESTVDTGPGEAAEGVPAVVDAVRTHQVATLLLGPDGSDTGREVWIGPGVDDVALQRGQARAMGVDKPVRARADDALLRSAAAAGSEVLVVPAGMPGPAGGLGAVLRWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN43</accession>
    <name>A0A0F4JN43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947171.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35249">
        <property type="protein sequence ID" value="KJY35249"/>
        <property type="gene ID" value="VR44_10585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470886" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7194" checksum="25448BEABF16D0FF" modified="2015-06-24" version="1">MAAMIPLRKSLLVAVSAIAALIGGGSAFAASNAAPLANDPSGARIQRTSPLTTLGTDRGSSYYYYYVQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN75</accession>
    <name>A0A0F4JN75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947436.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34391">
        <property type="protein sequence ID" value="KJY34391"/>
        <property type="gene ID" value="VR44_12010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6487"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471079" evidence="1">
        <location>
            <begin position="32"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="42484" checksum="0D0F0DAFAFE5BCF8" modified="2015-06-24" version="1">MPTRVRRHRTGLSAAALAAAALGTLLAPAQAAGAGPAGAGGHPGHDERLQRQLERLVAQEDGPPGAIAVLTRYGRTQVYTAGVGDLATGRRPDLDDHMRVASIAKAYSGAVALRLVDRGRLSLDDTIGERLPALPADWHAVTLRELLQHTSGLPDFSADPEFLRILQADPRHRFDPRTLLGFVADEPLLFRPGTLYEYSNSDNIAVALMAEAATGRRYEELLEELVYRPLGLRETSLPLGYRLPRPFLHGYDVSPPAEPEDVSEAIGASGVWASGGIVSTPRELGAFIRGYGGPALLSEATRKEQLTFRPGDSSEPAGPGTNAAGLAVYRYSTRCGVLHGHTGNFPGYTQLAATTPDGTRSLTFSINTQTSKGNKPALLARLRTVEEDFACALLKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNV3</accession>
    <name>A0A0F4JNV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000276">
        <property type="protein sequence ID" value="KJY34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34611">
        <property type="protein sequence ID" value="KJY34611"/>
        <property type="gene ID" value="VR44_11600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10181" checksum="1AFA73ED56CABB97" modified="2015-06-24" version="1">MEVEVRGAKLDARAQEGPVRSSPSVGHTDAAGVDHETAVGEADERHVGVAADHGADIGIESLEDLLPAVEAGVDQDDLLVVAGGGVAEQHLSQALHSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPJ1</accession>
    <name>A0A0F4JPJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000201">
        <property type="protein sequence ID" value="KJY35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946926.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000201.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35759">
        <property type="protein sequence ID" value="KJY35759"/>
        <property type="gene ID" value="VR44_09280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5183"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470920" evidence="2">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="19920" checksum="0B418CDC60ABE130" modified="2015-06-24" version="1">MGIRHMAKMRGGAALAVATLLALTAAGCGGGGGSDAKDASKPSQPQSQNAGAQASAPAKEQSSAPAVVIATLKGQEGMVLEINSVQRDPGGFLTVNGQIKNTGNEAFAGTSAWRGIELKGSGESLAGATLVDKVGKKRYYVLRDTESRCLCTTGFSSVAPGQVLPFFAQFPSPPANTTEVEFSLPTFATATVKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ08</accession>
    <name>A0A0F4JQ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946686.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36442">
        <property type="protein sequence ID" value="KJY36442"/>
        <property type="gene ID" value="VR44_07995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4423"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12283" checksum="E22240DD6475F643" modified="2015-06-24" version="1">MPVPLYQAKAEFFRMLGHPVRIRVLELLQDGPMPVRDLLAAIEVEPSALSQQLAVLRRSGIVTSTRNGATVVYELAGGDVAQLMGAARRILTEVLTGQSVLLEELRESEVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQS6</accession>
    <name>A0A0F4JQS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36530">
        <property type="protein sequence ID" value="KJY36530"/>
        <property type="gene ID" value="VR44_07885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471267" evidence="2">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14205" checksum="1B02045AAE8725B1" modified="2015-06-24" version="1" fragment="single">MNLHAHKGTRRSRARSRVLLASLAAAAALTGPLVATAPAASAAGPRPSDPAPSAPGKQRTPAGQQTPAKQRPPAGDQRRDPDRDHDEDPGREHGKDDHPHKRKPAAVAHGLRQFTSDNTFTPPAGVTSVFVQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQV3</accession>
    <name>A0A0F4JQV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000151">
        <property type="protein sequence ID" value="KJY36555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36555">
        <property type="protein sequence ID" value="KJY36555"/>
        <property type="gene ID" value="VR44_07775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4259"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21106" checksum="0342F123C8402010" modified="2015-06-24" version="1" fragment="single">WELPTATANIGTAAPLLAGLNAAADLASELGRDTDAGRWAQAARRLEAGIAKRFAPLGYGRTADGLHGRDSAAAFMAPPFNTAPADLPRALDDTYRELRRPNGGLVPGSDPDTRWGNITWTASTSFFALAWTASGERAKGDAVLDWVLDRRNLLGELPETVDAQGLPKAVVPLGWTDALVLLTLTGQEGRGPETPPGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRW6</accession>
    <name>A0A0F4JRW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946429.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37107">
        <property type="protein sequence ID" value="KJY37107"/>
        <property type="gene ID" value="VR44_06585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3234"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10526" checksum="07630EACA020CED2" modified="2015-06-24" version="1">MSTPTDDLGPLGSTISTALGSPRAVDVSVSLDDDSDTGRITLVASYEGKEPVRLTLDPHRAGCVAHLLMRAQATCEEHTRDYWEMQGAKTPRNAWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS68</accession>
    <name>A0A0F4JS68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946568.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36679">
        <property type="protein sequence ID" value="KJY36679"/>
        <property type="gene ID" value="VR44_07365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="32278" checksum="A650839BE989B565" modified="2015-06-24" version="1" fragment="single">MTLPSQRLGTGPGGELAEPGFWQRPPADRLAAFARLRALNSPVFVPEGGGRGGGHWALVRHADVQEASRLPKVFASAPGVTTPEPARWVRALFGDSMVNLDGPDHAQLRKIVQRAFTPRLLAAAEQDIHAVAARIVDDVLERRPDEFVSAVSSRLPLEVICNMMGIPERYRAEIADRVNHASENIGVERGLASRLRMPGRGLRALARMQRMVAGIGRERRRNPSDDLISALVCANVDGQALGARQLGAFFSLLMVAGVETTRNAITHGLTLLTDFPAQRDLLLSDFEKYADGAVDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSC5</accession>
    <name>A0A0F4JSC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000143">
        <property type="protein sequence ID" value="KJY36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36734">
        <property type="protein sequence ID" value="KJY36734"/>
        <property type="gene ID" value="VR44_07325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20134" checksum="86B6E5E5087DDCF7" modified="2015-06-24" version="1" fragment="single">MDDLVVVGAGPYGLSVAAHAAAAGLGVRVLGRPMASWRDHMPEGMYLKSEPWSSNLSAPGGRYTLAEYCATRGLTAEHGSPLPIGTFSAYGLWFARHAGLPEVEEVTVTEVAPEGDAFRVRTAEGPPLLARTVALAVGVMPFTHCPGALRDLPPAHWSHSSGHRDLSRFAGQEVAVLGAGQAALETAALLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTD7</accession>
    <name>A0A0F4JTD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946416.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37094">
        <property type="protein sequence ID" value="KJY37094"/>
        <property type="gene ID" value="VR44_06515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3216"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7998" checksum="BAA2A98BEBA7F21F" modified="2015-06-24" version="1">MDPRVVIHRPDEEGGRRVHIDGTILGLAKSERDLREFLRRVELPGWEDVDLNDTSLFKWEGPGPESWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTK0</accession>
    <name>A0A0F4JTK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37159">
        <property type="protein sequence ID" value="KJY37159"/>
        <property type="gene ID" value="VR44_06450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3202"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18994" checksum="6C80BDF19D0B609C" modified="2015-06-24" version="1" fragment="single">EAAGRLGQHPDELAMRGTLMLTASYSAAQAGWRGQAMDLIGEAEETAKRRETAAQRLYIPGEFGEAQTRGFRISVHHALGEDDQALTYAEKLDPRRLPTAERRGRMCMDVARVWQALDEPTKTFHALRALASYAPEEATRPKVRAIASELLMMNPEMPGLRRFSQKIGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU92</accession>
    <name>A0A0F4JU92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946665.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000154.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36531">
        <property type="protein sequence ID" value="KJY36531"/>
        <property type="gene ID" value="VR44_07820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4270"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="21200" checksum="6B458FB26522A8B5" modified="2015-06-24" version="1">MARTKEFDPDAALQSALELFWRRGYEATSVADLVEHLGIGRASIYATFGSKHELYLKALDRYAETQNPLLLSELSRPGPALPAVREVVRRFAAEAASPDRRRTGCFVTNTAAELAPHDGAAARRVEASWDRFETLLHSSLVRARAQGELPDGRDPQALARMLLVLLQGVRVVGKASGDPARVRDAAEQALALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV99</accession>
    <name>A0A0F4JV99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946018.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38075">
        <property type="protein sequence ID" value="KJY38075"/>
        <property type="gene ID" value="VR44_04380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.444"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="37379" checksum="FE52B46AF82FC3DC" modified="2015-06-24" version="1">MVTLSVIVAMCDVRDFCRTTLKSLALNAREDFEFIVVDDASVDGTSEILREMVPGIPGAVLIRNERNMGISATRNIGLAAARGRFFTFLDGDDWYAPGYLAQLVGWMSQSGVDFLRTGHVRVYGKKRKIVMPPLAPRALPLDPLDYMGPVDASTFIDYPSVWAGIYDRERLRQAGALFFEESLRTAEDRHWFYQLHLRMRSFGVVDLHGVFYRRDVSTSLTRIPDERQLDFLPAFRLVFGELAHHPRGYELSFKAMRTLCALIVIHLDRAQDYEEVTRALLWERSAQTLFDLPQDILEGTLAGMDSVRVNKLRALMSQQMSQHQGAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVQ2</accession>
    <name>A0A0F4JVQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000123">
        <property type="protein sequence ID" value="KJY37046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946451.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000123.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37046">
        <property type="protein sequence ID" value="KJY37046"/>
        <property type="gene ID" value="VR44_06695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3257"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470917" evidence="3">
        <location>
            <begin position="28"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="5">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="4">
        <location>
            <begin position="139"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="41252" checksum="9C4DD3CCC87BD00A" modified="2015-06-24" version="1">MRPARLTVLTAAAAVAALTAVTGCAEKSDKGGSDVIHVNATDSACEVSKTDFPAGKVSIEVENKGSKVTELYVLFPDDRIVAERENIGPGTKATITAEIKAGDYLFACKPGMKGDGIRTKVKATGKGAAEKRSPELDAAVASYRKYVQEQADETLPKAQAFADAVKAGDLEAAKKAYAPSRLGWERTEPVAESFGDIDPKVDVREDGLEAGQDPAKDWTGWHRLEKSLFQENKIDDNDKKLADTLITDLTAWQKKVGEAEITPTSMANGAKELLDEVATGKVTGEEERYSHTDLVDFKANVEGAEKSYELLKAVTAKNDPELAKQLDTQFAALNTLLDKYRADKNTYEFTSYDKVGEAQRKELSDGVSALAEPLSKLAAAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWB0</accession>
    <name>A0A0F4JWB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37276">
        <property type="protein sequence ID" value="KJY37276"/>
        <property type="gene ID" value="VR44_06085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2553"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7780" checksum="70A687E5ECF04AC4" modified="2015-06-24" version="1">MAGEKQHEHERERTHATVAPQAGRAQLTCPACGNPVDTVVRRRKSLGIFVPEWGRGPCRSPECPQYAPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY00</accession>
    <name>A0A0F4JY00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000054">
        <property type="protein sequence ID" value="KJY38714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38714">
        <property type="protein sequence ID" value="KJY38714"/>
        <property type="gene ID" value="VR44_03060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRTase_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="29211" checksum="7EDDF5BFA90A0DD4" modified="2015-06-24" version="1" fragment="single">MTMKGKTADTVWSGTWVAQRLGVRLRGPEGADGDGGLTELLGLALRRNPKRAHLLVSQVLGKHVPQSPATVYAAGYGLGERVRELLGERAASAVVLGYAETATGLGHCVADGVGAAPYLHSTRRPVAGVRPAGGFEEAHSHATSHLLLPEDPKLLAGDGPLVLVDDEFSTGNTVLNTIRDLHARHPRGHYVVVALVDMRSSADRDRLTAFAAELGARVDLVALASGTVTLPEGVLAKGQALVEEYEPRSHSGPPVPAAAPATGDGAVPTGTTGPAPAAGGGAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYS6</accession>
    <name>A0A0F4JYS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000076">
        <property type="protein sequence ID" value="KJY38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945974.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene822"/>
    <dbReference type="EnsemblBacteria" id="KJY38146">
        <property type="protein sequence ID" value="KJY38146"/>
        <property type="gene ID" value="VR44_04130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.114"/>
    <dbReference type="eggNOG" id="COG1946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="31837" checksum="3E408B92BCD4B19D" modified="2015-06-24" version="1">MNGALGDLLDLLDLEQIEENIFRGTSRTSLVPRVFGGQVAAQALVAAGRTVPADRTAHSLHSYFLRTGDAGAPIVYTVDRIRDGRSFTTRRVVAVQHGQPIFHLSASFQVYEEGLDHQATMPSAPDPETLPTAAEALPAYRDLFRDPGTVERLLEARGAVDLRYATTPPWGSIGEPVEPRSQVWFRTAGKLDSADPLLHTCLATYVSDMTLLDSVLLAHGRGGWAVGDVVGASLDHAMWFHRPLRADEWLLYDQDSPTSHGGRGLGQARIWTQDGRLAVTVIQEGVVRVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYX1</accession>
    <name>A0A0F4JYX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39029">
        <property type="protein sequence ID" value="KJY39029"/>
        <property type="gene ID" value="VR44_02385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6767"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="16915" checksum="0AFDE163D39E60C4" modified="2015-06-24" version="1">MDGRERDRDGAGRARSARPRDGLGRPLAYGEDGVARQPEGVVRGPGETVAEAQRLLDAGMPFHAHEVFEDAWKSGPEEDAPLWRGLAQLAVGLTHAARGNAVGGARLLRRGAASLGGVERAYGMDLPGLVRWAGELAHRVEAGAVVDAAREAPRLGGGGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ19</accession>
    <name>A0A0F4JZ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000072">
        <property type="protein sequence ID" value="KJY38261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38261">
        <property type="protein sequence ID" value="KJY38261"/>
        <property type="gene ID" value="VR44_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="20441" checksum="01DC2EDEAA1F7D43" modified="2015-06-24" version="1" fragment="single">ERKESAERDLAEALRREAELEESVRRLAPRLQRAQQTWHELAQLAERVRGTESLAQARVRSASAPVEEERRGRDPEDMEREAARIREQEAELTAALEASERALEDTAAHRAELERALAEEERRLRDAARAVADRREELARLTGRLGAARSRAGAAQSEIDRLAAARDAARERAEEAREEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ58</accession>
    <name>A0A0F4JZ58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein PaaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945341.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4811"/>
    <dbReference type="EnsemblBacteria" id="KJY39687">
        <property type="protein sequence ID" value="KJY39687"/>
        <property type="gene ID" value="VR44_00660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2838"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17893" checksum="AE9D5F794BA67BE5" modified="2015-06-24" version="1">MVTAAAATTRLEAELAELAGTVPDPELPVLTLAELGVLRGVRMHDDGHAEVLLTPTYTGCPAIEAMSADIERVLTGHGIPEVRVTTVLSPAWSTDDISAEGRRKLAEFGIAPPRPHSAGGPVPLTLSVRCPHCGSTDTELLSRFSSTACKALRRCVACREPFDHFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZU4</accession>
    <name>A0A0F4JZU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuC</name>
        <name evidence="17" type="ORF">VR44_02010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39218">
        <property type="protein sequence ID" value="KJY39218"/>
        <property type="gene ID" value="VR44_02010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5808"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="8"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="465" mass="49787" checksum="2340322E10DD259F" modified="2015-06-24" version="1">MARNTLLERVWAEHTIDGTGGELVYVDMHLLHELTSPQAFEGLREAGRKVRRPDLTVATADHDVPTRSRQVPLSDSIGRRQLGLQIRNSREFGVELHPMNSLGQGIVHVIGPQMGLTLPGMLIVCGDSHTATHGAFGAVAFGIGTSQVEHVLATQTLRIAKPKSMRVLVEGTPSAEATAKDIALAVIRAIGTDGGTGHLIEFQGDVIDRMSMEGRMTLCNMAIEAGARSGMIAPDETTFAYLEGRERAPRGEDWERAKEAWAAYRSAPDAEFDREVVVDVDGLRAMVTWGINPGQAVPVDGRVPDPETMADPVSREAGRRALDYMGLRAGQSLADIPIRTVFIGSCTNGRMDDLRAAAKVVEGHKVAAEVTALVVPGSERIKRQAEAEGLDRVFTEAGFEWRNPGCSMCIAVNGDRVPAGTHSASTSNRNFEGRQGPGARTHLVSPETAAATALLGRLAGSAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K013</accession>
    <name>A0A0F4K013_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">VR44_00405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956432.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4K013"/>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1049"/>
    <dbReference type="EnsemblBacteria" id="KJY39957">
        <property type="protein sequence ID" value="KJY39957"/>
        <property type="gene ID" value="VR44_00405"/>
    </dbReference>
    <dbReference type="GeneID" id="63982150"/>
    <dbReference type="GeneID" id="66955266"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.79"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14384" checksum="82DE7DB9D0D48982" modified="2015-06-24" version="1">MPPKGRQGAAKKVRRKEKKNVAHGHAHIKSTFNNTIVSITDPSGNVISWASAGHVGFKGSRKSTPFAAQMAAESAARRAQEHGMRKVDVFVKGPGSGRETAIRSLQATGLEVGSIQDVTPTPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0H7</accession>
    <name>A0A0F4K0H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945394.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4753"/>
    <dbReference type="EnsemblBacteria" id="KJY39614">
        <property type="protein sequence ID" value="KJY39614"/>
        <property type="gene ID" value="VR44_00960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2905"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="37917" checksum="F82D96C010DD52A7" modified="2015-06-24" version="1">MALTLYVDTARWRAHQKTIIDQFPGLIPVCKGNGYGFGHERLCEEATRMGADILAVGTTYEAASIKDRFGGDLLVLTPFRRGEEPVPLPDRVIRSVASVDGVRGLVGARVVIECMSSMRRHGISEQDLGLLHSAIEDVRLEGFALHLPLDRPDGSDAVEEVIGWMDRLRAARLPLHTMFVSHLRAEELARLQQQFPQTRFRARIGTRLWLGDHDATQYRGAVLDVTRVAKGDRFGYRQQKAASDGWLVVVAGGTSHGVGLEAPKALHGMMPRAKGVARAGLATVNRNLSPFVWAGKQRWFAEPPHMQVSILFVPSDATEPKVGDELVAHLRHTTTQFDRVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0U9</accession>
    <name>A0A0F4K0U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_01330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945461.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4681"/>
    <dbReference type="EnsemblBacteria" id="KJY39553">
        <property type="protein sequence ID" value="KJY39553"/>
        <property type="gene ID" value="VR44_01330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2982"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="223"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="41841" checksum="9F8858E00EA1058D" modified="2015-06-24" version="1">MHLAPSEGQSRLRAELREYFRDLLPDGVPEDPAAQRALLRRIGADGLLGLGWPVEYGGQGRGPDEQFVFFDEAYRAGAPVSMVTLNTVGPTLMKYGTPEQKDYFLPRILRGETVFAIGYSEPEAGTDLAALRTRAVRDDSGDWVIDGQKVFTSNAQNADWIWLACRTDPQAPKHKGISIILVPTDSPGFSWTPIDTVGGLTTTATYYDGIRVPAGHLVGPEHAGWGLITNQLNHERVALAALGMQAEDFYEAARTHARTPDPVTGERPADRPWVRARLAEAHARLAAVRLLNWRLVQDVGAGTLAPGDASGVKFLGTESTVEVYRICQEVVGEEALVRGPGAFLGGELERMNRAAQINTFGGGVSEVQREIVAMMRLGMKGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I257</accession>
    <name>A0A0F4I257_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AdoMet activation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_40610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001789">
        <property type="protein sequence ID" value="KJY16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16095">
        <property type="protein sequence ID" value="KJY16095"/>
        <property type="gene ID" value="VR44_40610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6964"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10998" checksum="B45C072A4052E309" modified="2015-06-24" version="1" fragment="single">AEALAEYWHARVRAELGIAGSDPAGMDGMFRTEYQGCRYSLGYPACPELSDRAKIADLLRPERIGVHLSEEFQLHPEQSTDALVIHHPEAGYFNAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I800</accession>
    <name>A0A0F4I800_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001662">
        <property type="protein sequence ID" value="KJY17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17578">
        <property type="protein sequence ID" value="KJY17578"/>
        <property type="gene ID" value="VR44_39930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="39164" checksum="7F04892880B8A36A" modified="2015-06-24" version="1" fragment="single">SHAFHSPLMDPMLDDFRKLVEAVPFAAPALPVVSTVTGRRLAASELADPEYWVGQARAAVRFADAVRYLADAGASLFVEIGPGGVLTGLAQPLLDADSAHAVPLLRTRTDEDLAAASALARLHVHGVPLDPAALSGGRAGRPALHDLPTYAFQRRRHWLESTAFSGRPAADAARAADPAEAGFWDSVERADLAAFAQRLGLADDAPLSSVLPALSLWRRSHQERSALDGRRYRIAWQPAPAASAPATALGGGWLALVPAGRPAGDPWTADALKALEEHGATVRPLEVEPGTGREALAELLRTAAHGHAVDGVLSLLAVDEQPHRTHPALAEGLAATLALIQALGDAGIDAPLWCATRGAVSTGASDPLRSPRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I905</accession>
    <name>A0A0F4I905_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_39790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001639">
        <property type="protein sequence ID" value="KJY17938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17938">
        <property type="protein sequence ID" value="KJY17938"/>
        <property type="gene ID" value="VR44_39790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6140"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="185"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="346"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY17938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="469" mass="48841" checksum="1FB6ECF588E24158" modified="2015-06-24" version="1" fragment="single">TDYWTGKTYAGPGWLNGYQAPLDTLPLFVKGGAIVPMWPQMNYSGEKPVSTLTYDIHPRGTSAFDLYEDDGRTRAYTTGAYARQHVDVTAPASGSGTVTVDVGAPTGSYAGQPASRGYELTLHVASAPTALTLDGTALTRLTSKAAYDSATTGWFFDPADRAGVLWVKTGTRTSGFTVTATGTTVPAPSPVPTTSSPISPSSWTLLSADSQETAAENGAAVNAFDGNPATIWHTAWSSNKPAALPHEIRIDLGARYTVDGLGYLPRQDGGVNGRIGGYEVYVSDTTTDWGTPAATGTFADTAAAKSVTLAPRTGRYLRLRALTEAGGRGPWTSAAEITLTGRPTPLPSHATLVNAASSTCLDLPHSATAPGTAPTLYSCHGGPNQRWTLQNDGRLTGLNDVCLDATDPARITVQPCAGTPAQTWQPGPDGSLRTSGQCLTPAGGGTANGTDLTRTPCKGTPSQRWTFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I973</accession>
    <name>A0A0F4I973_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001681">
        <property type="protein sequence ID" value="KJY17241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952621.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001681.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17241">
        <property type="protein sequence ID" value="KJY17241"/>
        <property type="gene ID" value="VR44_40065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6353"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21956" checksum="BFBA9E98448398DB" modified="2015-06-24" version="1" fragment="single">PWDGGRWLAVRWVDGVPLWRALALARGPEGDRPSVRPWLQQIARTWAEHLAGLHAAGWAHADVQPTNTLITSGGRAEVIDYALACGPEPDGRLPYRGALTHTTAPEIAAAVLATPADTHVQAEPAADVWSLGASLFWCWTGHRPVPYDDSLDRLDKLAVVATGSTTPLADVRPWPFPDFAATITACLAPDPADRPTAKELIAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IA76</accession>
    <name>A0A0F4IA76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001573">
        <property type="protein sequence ID" value="KJY18935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18935">
        <property type="protein sequence ID" value="KJY18935"/>
        <property type="gene ID" value="VR44_39290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5660"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8061" checksum="74CA1867D065DE6B" modified="2015-06-24" version="1" fragment="single">TFTNTGTIAARSGTVSFATHVIGALGIDWATVTTTQPLPAPIAGLTSRTQTYTVCVEAWRVPLGMHVETLGVTATWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ID74</accession>
    <name>A0A0F4ID74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001526">
        <property type="protein sequence ID" value="KJY19942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19942">
        <property type="protein sequence ID" value="KJY19942"/>
        <property type="gene ID" value="VR44_38890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5494"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469381" evidence="2">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14330" checksum="4682CCB4949658C6" modified="2015-06-24" version="1">MYRVPVGTVLACGLAVGLATPSAAASKLLSLKLNAPYVTVSFLDTEPHDKSNVLVLRPEGGGETLRVILSDEIPGVGKTVVKKLDAGIRPGTRYCAAVEVATVTAEEPTGVPTELPTALPEPDDVGTIYETGTVCADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGD1</accession>
    <name>A0A0F4IGD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001468">
        <property type="protein sequence ID" value="KJY21095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952315.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001468.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21095">
        <property type="protein sequence ID" value="KJY21095"/>
        <property type="gene ID" value="VR44_38395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5328"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19210" checksum="06E14201566D30F2" modified="2015-06-24" version="1">MTTRTLYLFCSAAPPVFDVAHVIEEAQARDWDVCLGLTPAAAEWLEESLAGLEALTGHPVRYRYKRPGQPDVWAPADAVLVAPATTNTINRWALGITDSFVVGFVAEALGKDIPLTLMPCVNAAYAQHPQLPLSLETLRTAGVNVLFGEDGFQPNPPGEKRPYPWAVALDALESVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJ05</accession>
    <name>A0A0F4IJ05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001436">
        <property type="protein sequence ID" value="KJY22005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1551"/>
    <dbReference type="EnsemblBacteria" id="KJY22005">
        <property type="protein sequence ID" value="KJY22005"/>
        <property type="gene ID" value="VR44_38100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5224"/>
    <dbReference type="eggNOG" id="COG1188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7258" checksum="D02ED2112EED5424" modified="2015-06-24" version="1" fragment="single">MADTKSTGGTAAGPGPLEAGTARVDAWIWSVRLTKTRSVAATACRAGHVKVNGERAKPAQQVRAGDEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILA7</accession>
    <name>A0A0F4ILA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001421">
        <property type="protein sequence ID" value="KJY22434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22434">
        <property type="protein sequence ID" value="KJY22434"/>
        <property type="gene ID" value="VR44_37920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5145"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY22434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19894" checksum="720CC44F547EBA6C" modified="2015-06-24" version="1">MPEGGVPFAEIFPYEGDIRIKELDAPVLPEPPRDGEGGRPCHGCQDDGAPVLWSDEHWKVRGFAEPEGVPAQVMLLPREHGDLADLPPARAAELGGMLQRVERAVMALGGIGRVHVNRWGDGGSHFHVWFIARPAGMLQLRGTCLPLWGDVLPKVPLEEWEETNRRIALALAGEGGTAHVGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILE5</accession>
    <name>A0A0F4ILE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001425">
        <property type="protein sequence ID" value="KJY22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952231.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22313">
        <property type="protein sequence ID" value="KJY22313"/>
        <property type="gene ID" value="VR44_37950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5154"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32558" checksum="EB23B8BBFC1EB90B" modified="2015-06-24" version="1">MTAVQAPYARIAAELRGRIERGELLPGDRVPSTRAITQRWGVAMATASKVLALLGQEGLVRAVPGVGTVVAARPAAGGPGRRPAAEDDTAQRTRIIRAAVALADAEGLAALTMRRLGAELGVSAMSLYRHVSNKEQLVVLMADAAFGEEALPERPPAGWRERLELSAALQWRLYRTHPWLAGAMNLSRPLLIPNGIRHIDWALAALDGLGLDADTRMHAAVTLFGYVRGHAVDLEPETDATRTSGVTGQEWMHAQETRLAALVDSGAFPAFAAARTGSALSPESLLHHGLTTLLDGLATRITTPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQM1</accession>
    <name>A0A0F4IQM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001323">
        <property type="protein sequence ID" value="KJY23954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952012.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001323.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23954">
        <property type="protein sequence ID" value="KJY23954"/>
        <property type="gene ID" value="VR44_36765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22486" checksum="8B50D9E7D7E6CB03" modified="2015-06-24" version="1">MHVFVLSGSSRTGSVNARLAALVAGLVVRTGATAEPALLGDFPMPLYDGDVEADEGVPAGALALRERIEAAQAVVIASPEYNASVPGPVKNAVDWVSRVRPQPFKDKQVLLVSASPSMVGGNRGLWALRVPLEHLGARVYPDMFSLAAAHQEFTEDGALADRGLGERLASTVDAFLDLAEADTRYLCLQRRWYEFLGDRTDAPVTARAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR22</accession>
    <name>A0A0F4IR22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001287">
        <property type="protein sequence ID" value="KJY24124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951916.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24124">
        <property type="protein sequence ID" value="KJY24124"/>
        <property type="gene ID" value="VR44_36265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4500"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="32756" checksum="3C67BBA13B1DF91D" modified="2015-06-24" version="1">MRVTQSRSSGLDLNLLLALDVLLEESSVSAAAARLHLSEPAMSRTLGRIRKALGDPVLVRAGRSMVPTPHALSLQGEVRSVVERARALFLTGGEVDLRTLERTFTVLAHDSFAATFGATLFQRMAEEAPGVRLRFLSESHVDVPALREGVADLEVGVIDNRSPEVCVEHLFDERMLGVVRPGHPLLRGPLTARRFAAGEHLIVSRRGRLEGPVDAALAEQGLSRRVVGSIGSYPASLFVLRETDLIGLIATRTVRQAEALGLVTFEVPLELPTLPFAWHPRHDADPAHAWLRARARALVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR70</accession>
    <name>A0A0F4IR70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001219">
        <property type="protein sequence ID" value="KJY24487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24487">
        <property type="protein sequence ID" value="KJY24487"/>
        <property type="gene ID" value="VR44_35205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4122"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12811" checksum="6DED00A461BD3E71" modified="2015-06-24" version="1">MDVQHFERITAFIEARLTPLFDAETGSERGFAMDDTSRALRALRNSVLEASAVKGLIATRETAEPLVRKVIDQSVEHHWDVLRGIARQWEDHADFRREFKRHAWELDGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK2</accession>
    <name>A0A0F4IRK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001292">
        <property type="protein sequence ID" value="KJY24103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951923.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24103">
        <property type="protein sequence ID" value="KJY24103"/>
        <property type="gene ID" value="VR44_36310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4512"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="8961" checksum="B64A816F85F0F3D1" modified="2015-06-24" version="1">MPRPTAAQLAYGSATVIVSTIAMLLLSQTSTGIGVAVISAAALALGLLVALTVPLPRRRGRHAAVRSGGRPAPGLRRPACADARGRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRR3</accession>
    <name>A0A0F4IRR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001183">
        <property type="protein sequence ID" value="KJY24682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24682">
        <property type="protein sequence ID" value="KJY24682"/>
        <property type="gene ID" value="VR44_34615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3908"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="165"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="41017" checksum="E8324A88A1FBB0E0" modified="2015-06-24" version="1">MGSVPPQACPDRRGPDGGAGGRAPAPDTGGTPGQGHGFGLDPDELPDGLVVADHTGHVVCFNRAASRITAITAAQALGARIERALPLEDLEGRRWWALTDPYGGLATRRGQPERNLLLPGGREVLVSARYVRTHPTGPLSRLVVTLRGTEARHRTERSHAELIATVAHELRSPLTSVKGFTATLLAKWERFTDDQKRLMLETVDADANRVTRLIAELLDISRIDSGRLEVRRQPVDIAAAVGRHVQALTANGQAPERFLVRVSRPLPDLWADPDKIDQILGNLLENAVRHGDGTVTIDVAPYEKGTAVTVTDEGPGIPEESMARVFTRFWRGSKRGGTGLGLYIVKGIVEAHGGTITVGRGPGGGAEFRFMLPVSAPAYLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRX8</accession>
    <name>A0A0F4IRX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001264">
        <property type="protein sequence ID" value="KJY24238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24238">
        <property type="protein sequence ID" value="KJY24238"/>
        <property type="gene ID" value="VR44_35955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470350" evidence="2">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="19433" checksum="04D7A5EC72AD279E" modified="2015-06-24" version="1" fragment="single">MPAPGRLRPSALCAAGAALVSLFVAVRAGALSHLWEFLDYGVGVLSLVSLTATVLWGLAATDRAVLGSGHRLLAQGVHRGLAVAGLGFLALHVWVKVAQGHTTAAGAFLPFADEDRPVLIGLGTLAGYLFVSVAVSGAVRSVFAVKNRSVWWRALHIGAYPAWGASLVHGLKAGRAADAWVTASYALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISC7</accession>
    <name>A0A0F4ISC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001151">
        <property type="protein sequence ID" value="KJY24902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24902">
        <property type="protein sequence ID" value="KJY24902"/>
        <property type="gene ID" value="VR44_34040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3735"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11717" checksum="68862824CDF27FD8" modified="2015-06-24" version="1" fragment="single">LMTDRHIKRLPVVDADGTLKGIVSRADLLKVFLRSDDELAAEIRQSVIRRLFPLSHEAVKVTVSQGTATLTGRVRDHTLIPMAERLTHSVEGIVDVHCRLEGLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL6</accession>
    <name>A0A0F4ISL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001225">
        <property type="protein sequence ID" value="KJY24458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951732.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24458">
        <property type="protein sequence ID" value="KJY24458"/>
        <property type="gene ID" value="VR44_35290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4170"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="53"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="23724" checksum="2B2E2FCADBD1A3FF" modified="2015-06-24" version="1">MRRDPGGRAAEQVSDTPSLKGAAVGRRIGIGLMYGLWKPRVLGAWKVPATGPVILAVNHAHNIDGPLVMGTAPRPLHFLIKKEAFVGPLGPFLEGIGQVKVDRSGTDRTAVTRALEVLGNGGALGIFPEGTRGDGDFASLRAGLAYFAVRSGAPIVPVAVLGSTDAKGRLVKGLPPLRSRVDIVFGSAFEAGDGTGRRTRTALDAATVRVQDRLTAHLADAKRLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISQ0</accession>
    <name>A0A0F4ISQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001219">
        <property type="protein sequence ID" value="KJY24488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951719.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24488">
        <property type="protein sequence ID" value="KJY24488"/>
        <property type="gene ID" value="VR44_35210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4123"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8140" checksum="2716B328C516DC56" modified="2015-06-24" version="1">MPDPLTVPPLPTAAPECRTEPGPLPACPRCAVPPERISWRQRPGEPVVLLFEPCGHRHASPAPPLLAVTAPGPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISZ7</accession>
    <name>A0A0F4ISZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25117">
        <property type="protein sequence ID" value="KJY25117"/>
        <property type="gene ID" value="VR44_33350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3547"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470226" evidence="2">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="15551" checksum="FD3BE0032FACF7EE" modified="2015-06-24" version="1">MKFTAVIVGVVLSLTGFSAHGRHGGGSGGHGCSSGKSSHSSSNDVNNSNNSNNSTSSGSTGTGKGNKSDAPAHATVLSCAAPGRTKAVLQVTSDLDTQRTVDVPLTFEGNAGTVDRTSVRVTLKPRETQTVTVAMVNPAKVNEVQRCQVGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT16</accession>
    <name>A0A0F4IT16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001168">
        <property type="protein sequence ID" value="KJY24799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951551.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001168.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24799">
        <property type="protein sequence ID" value="KJY24799"/>
        <property type="gene ID" value="VR44_34300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15107" checksum="A01B23CBEF000897" modified="2015-06-24" version="1">MLLSRWRRWRRGRPFWGGLFAVLAGAWICVLPLAPLKIMLQQGIAGIPSVLMGIIMIVLGLTAWLSPRQRALAGVLTTLIATAALVLSNLGGFLIGTLLGILGGGLMFAWQPYAAPRAGGSAAPARPSPAGTSPAPHPDPQGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT28</accession>
    <name>A0A0F4IT28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_37060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001345">
        <property type="protein sequence ID" value="KJY23861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23861">
        <property type="protein sequence ID" value="KJY23861"/>
        <property type="gene ID" value="VR44_37060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY23861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="29810" checksum="F7E66CCCF407794D" modified="2015-06-24" version="1" fragment="single">LDLDRAVERLAAGSLGARAVSDTGPPELRRLRRHFNGMAEAVADSLGRQRAFVADASHQLRNPLATLVLQLENVEPHITPGPGLAEHARALDEAERLEELLDGLLSLARVESGTAERGDQDLVAAVRGRVEAWEPVFRAAGLELAADVPPRELCVRALPDAAGRILDALLDNAVKFVPAGGRVEVRVPGPAGGEALVRVADDGPGVPDGQRELLLRRFARAPEHQNVRGSGLGLAIAEEIARLSGGRLEVAGNEPRGLVFEFRLPSPPPSSAEGQPYTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITB3</accession>
    <name>A0A0F4ITB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_34530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001178">
        <property type="protein sequence ID" value="KJY24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951593.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6931"/>
    <dbReference type="EnsemblBacteria" id="KJY24713">
        <property type="protein sequence ID" value="KJY24713"/>
        <property type="gene ID" value="VR44_34530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3890"/>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="37239" checksum="EBA962CA1BA63369" modified="2015-06-24" version="1" fragment="single">MDLLNTLVDKGLRRELPTREEALAVLATSDDELLDVVAAAGKVRRQWFGRRVKLNYLVNLKSGLCPEDCSYCSQRLGSKAEILKYTWLKPDEASAAAAAGVAGGAKRVCLVASGRGPTDRDVARVGETIAAIKEQNEGVEVCACLGLLSDGQAEKLRDAGADAYNHNLNTSEATYGQITKTHTYADRVDTVQKAHAAGLSACSGLIAGMGESDEDLVDVVFSLRELDSDSVPVNFLIPFEGTPLAKEWNLTPQRCLRILSMVRFVCPDVEVRIAGGREVHLRSMQPLALHIANSIFLGDYLTSEGQAGQADLDMIADAGFEVEGAGTTTLPAHRADAAEAAAAAHGGGVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU39</accession>
    <name>A0A0F4IU39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001113">
        <property type="protein sequence ID" value="KJY25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951353.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001113.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25164">
        <property type="protein sequence ID" value="KJY25164"/>
        <property type="gene ID" value="VR44_33225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23198" checksum="DB631624E97E713E" modified="2015-06-24" version="1">MTYSGAVKVGGPADVHELADLMISKVAVGSMNNNAYLLRCRATGEQLLIDAAAEPETLLNLIGDDGIASVVTTHRHGDHWGALQAVVDATGARTYAGAHDAEGIPVPTDVLVHDGDVITVGRVSLTARHLVGHTPGSIALVYDDPHGHPHVFTGDCLFPGGVGNTWGDAKNFASLIDDVETKLFGQLPDETWVYPGHGNDTMLGTERPHLAEWRERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUE1</accession>
    <name>A0A0F4IUE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_32025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001045">
        <property type="protein sequence ID" value="KJY25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951134.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25622">
        <property type="protein sequence ID" value="KJY25622"/>
        <property type="gene ID" value="VR44_32025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3123"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031014">
        <property type="entry name" value="rSAM_BlsE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00517">
        <property type="entry name" value="cytosylglucuronate_decarboxyla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35864" checksum="833D7F793D8EEF16" modified="2015-06-24" version="1">MRARDRYLFIRILEACNADCFMCEFALSRDTYRFSPEDFADLLPKARDAGVGYVRFTGGEPLMHPDVVDLVRAGTAAGMKMSLITNGSLLPRTAAPLAAAGLAQVIVSLDGASGATHDVYRRTPGLFDSGLRGLREAAALGVLPRVNTVVGPHNYAEMPRLQEVLTEAGVRQWELSALKLDRTITYPDADHVRSVCDPIYDADPAALLVPMGKRFYGDTPQEQERYFTGSVTPRAAEPLCHVADDVIYVDGKYGRMYACSCIPHREGDDGPGGAPLREQGVVRLDTPVFRAHADYFRERGPQVCSGCSTTAAGYSDDVARLGEVGAWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF4</accession>
    <name>A0A0F4IUF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001043">
        <property type="protein sequence ID" value="KJY25637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951127.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25637">
        <property type="protein sequence ID" value="KJY25637"/>
        <property type="gene ID" value="VR44_31985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3113"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25426" checksum="9C63125E1F26957D" modified="2015-06-24" version="1">MKFAVIGGTGLIGSQVVKNLNAARHEAVPHSQSTGVDVISGQGLDEAVAGADVVVNLTNSPTFDDASLAFFQTSMDHLLAAAHKGGVGHFVILSIVGVDQVPELDYYRAKVLQENILAAGPIPYSIVRATQFMDFMEAVLSWTADGDTIRLPATPIQPIASKDVADAVAEVASGVPLAGIRNIAGPEIFSLDDLGRLTLSRKGDNRTVVTDPTAGMFAVVKGDALTDKDAQLAPTRYTDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV06</accession>
    <name>A0A0F4IV06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001016">
        <property type="protein sequence ID" value="KJY25865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25865">
        <property type="protein sequence ID" value="KJY25865"/>
        <property type="gene ID" value="VR44_31385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIT" evidence="2">
        <location>
            <begin position="68"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="640" mass="69276" checksum="ECF69A1BF6DFFA13" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVU2</accession>
    <name>A0A0F4IVU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_34250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001166">
        <property type="protein sequence ID" value="KJY24811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951542.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001166.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24811">
        <property type="protein sequence ID" value="KJY24811"/>
        <property type="gene ID" value="VR44_34250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3822"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="35396" checksum="4E5B144C5737E3C9" modified="2015-06-24" version="1">MAEGSAGAATAPPRSFIPHGGGVDPERRRGRTGTAGAALVGAVAVVVLAGPWLEPLFGLAAFGAWRTLLVAIVMQGVPFLLLGTVVSAAIGAFVPARVFSRVLPRNPVLAVPVAGAAGVVLPGCECASVPVAGSLMRRGVAPAAALTFLLAAPAVNPVVLVATAIAFPGRPEMVAARFGASLVTSVVMGWLWIRWGREEWLRLPAARAEHAPGTGRLEAFRRGLQHDFLEAGGFLVVGAMAAATFNVLVPPSVLEAFSGSPWLGVLVAAALAVLLSVCSEADAFVASSFTGFSPTARLAFMVVGPMVDMKLIALQSGAFGRPFAVRFCAATFVVAILCSALVGGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWZ0</accession>
    <name>A0A0F4IWZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001109">
        <property type="protein sequence ID" value="KJY25201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951338.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001109.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene590"/>
    <dbReference type="EnsemblBacteria" id="KJY25201">
        <property type="protein sequence ID" value="KJY25201"/>
        <property type="gene ID" value="VR44_33150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3502"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22292" checksum="D2936549842E3961" modified="2015-06-24" version="1">MAFGRSSRTGAMHAVSPVEPLTLKILVAGGFGAGKTTLVSAVSEIRPLRTEETLSEPGAGVDDTGGVEGKSTTTVAMDFGRITLREDLVLYLFGTPGQDRFWFLWDELSQGSLGAVVLADTRRLADCFAAVDYFERRGLPFLVAVNCFDGAERHPVVTIREALDLDPEVPVLLCDARDRESVKDVLVGVVEHAMSLARARRAGLTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXG7</accession>
    <name>A0A0F4IXG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000977">
        <property type="protein sequence ID" value="KJY26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26143">
        <property type="protein sequence ID" value="KJY26143"/>
        <property type="gene ID" value="VR44_30775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2611"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="192"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="38671" checksum="BAD3ADE4ACFA8AB1" modified="2015-06-24" version="1" fragment="single">VPPPARPGGHPEQREEGGAWGTDPAPASLYGDWRGTPRPAAAPAPGADTPAAGAPAAGSSRTTGQPPAPAAEALTSTGSHRRVPGPRKPTAPGGAGRPANGRSTRVRVYTGVAALAVTAVLAVVVANQVTTEGDPAATGARAAGDDGPQRAPGDKTASRSDGRPTPASPPPAQPPTYEQQMAQQLPIDAKLTGPGVFDTVPGVAKAPGKGKVVRYRVDVEQGLGMDAQLFAEAVQRTLNDPRSWGHDGAMTFERVPEGKADFVITLASPGTTGAWCAKSDLDTTIDNVSCDSASTERVMINAFRWGQGSPTYGADQMLAYRQMLINHEVGHRLGHGHVSCTKPGSLAPIMQQQTKSLDIDNIHCLPNPWVFPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXQ8</accession>
    <name>A0A0F4IXQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000963">
        <property type="protein sequence ID" value="KJY26253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950861.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000963.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26253">
        <property type="protein sequence ID" value="KJY26253"/>
        <property type="gene ID" value="VR44_30545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010147">
        <property type="entry name" value="CRISPR-assoc_prot_CasD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01868">
        <property type="entry name" value="casD_Cas5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9908" checksum="D62D01CFDC40EA2B" modified="2015-06-24" version="1" fragment="single">MSVLALRLAGPLQSWGSSARFARRTTETAPTKSGVIGMLAAALGRDRTADLSDLAALSFAVRIDQPGTRLRDFQTARHADTGKAMPVSERFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY16</accession>
    <name>A0A0F4IY16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000927">
        <property type="protein sequence ID" value="KJY26544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950725.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000927.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26544">
        <property type="protein sequence ID" value="KJY26544"/>
        <property type="gene ID" value="VR44_29790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2338"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="11"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="31693" checksum="2583CEEE376D9621" modified="2015-06-24" version="1">MILTVTLNTALDVTHRVPRLRPHTSHRVTAVTERAGGKGLNVARVLAALGHEVTATGFAGGPAGAVVRDLLAGSPGVVDALVPCAGTTRRTVAVVDESTGDTTQFNEPGPQISATEWAAFLTRYTELAARARAVALCGSLPPGVPVGAYAVLVRAARAAGAPVLLDTSGEALRRGVAARPEIIKPNVAELAELTGSRDPLPATRDARRRGAHAVVASLGPEGLLAATPDGTWQATPPRTLRGNPTGAGDSAVAGILSALTEDLPWPDRLTRAVALSTATVHAPTAGEFDPRTYAEVRGSVKVTAVPAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY56</accession>
    <name>A0A0F4IY56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent carboxylate-amine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001049">
        <property type="protein sequence ID" value="KJY25606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25606">
        <property type="protein sequence ID" value="KJY25606"/>
        <property type="gene ID" value="VR44_32055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3130"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAL_C2" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20582" checksum="B65F24350B9A76E9" modified="2015-06-24" version="1" fragment="single">CRPLDIVDGAMNANISVGTGEGPPVDLRALVQRVVTGMGIDHGYAHMEFFLIDGEVYAGEIGVRLAGCEIPANHGHAYGFDVFGATLAVYLGRRPDLRYGERRCAGDLLLPLPGSGTVRRITSREELLAMPGVIDAVLKVRSGDTVTARRASHNASGYAHVVGASVGEVESRMRDVLARFTIEVVAQEPSAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZH8</accession>
    <name>A0A0F4IZH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000986">
        <property type="protein sequence ID" value="KJY26076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950930.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000986.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26076">
        <property type="protein sequence ID" value="KJY26076"/>
        <property type="gene ID" value="VR44_30920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2689"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32423" checksum="49F1257498F3561D" modified="2015-06-24" version="1">MGWDWTDAGDIRRRLDQGADPEAWSGGRPLHRAAVFGSPEVVTELAGRVEDVDALENDVTALWEAVVSKKPDNARALAAAGADPWRELIGGWSPGRLSLAGPTPDLFDVPAGQQLNTGERTAAEEAARLLGALGSFYYEGTGLACVTGIDAAEAVRRLEATPVPDGAIEELLEDPYAYDEDMEVIGVTSVPGGCVVTQPWGDAPQMPGVLTRLSRGTVCYGLYANPKSGNQGSIARDGAITGGDLHPGGGAQEGDTPEEVLDAYPYQYNAVAYSCAFTGLRLSDARAVVGPPDLWVQLPQRDYWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J249</accession>
    <name>A0A0F4J249_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26981">
        <property type="protein sequence ID" value="KJY26981"/>
        <property type="gene ID" value="VR44_28645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2060"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="270"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="36938" checksum="B8950D4995D7C264" modified="2015-06-24" version="1">MPVDADGADGSDLSPAARRLYAFAVERYAFTAAEATTALGARAGAAVKELAAAHLLQRAPGDGPERWTAVAPRAAAARALAPLALLVRETHDEMDRLRGRLEALVPAYEAGTAHRDDGGAGRLELVTDLGAVRGLIAELVAGCEHELLTSQPGGGRPQETLEEAVGRDESLLARGVRMRTIYQHTARYSRPTAAYVERVTALGAQVRTLGDGLMRMLIFDARTGLMSVPDRQGAALLVREPSVVHFMTAAFERSWPAARPFPTTVSPESARSLSDELRQTIVRLLSEGLEDKVIARRLGMSERTCQRHIAEIMRAVGAKSRFQAGYLLSAAAAGRPGEEPGTGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5K8</accession>
    <name>A0A0F4J5K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000672">
        <property type="protein sequence ID" value="KJY29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29124">
        <property type="protein sequence ID" value="KJY29124"/>
        <property type="gene ID" value="VR44_23665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.678"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11198" checksum="5ECBF639E8112E61" modified="2015-06-24" version="1" fragment="single">VLAAAYQALYQDGDVRSTRAQVSAAIEGLRDADGPAGTRTGTEEVLHRLVVLLLAISQYSGDRAVWESTRSLLASTGGPATDRARLYGDTWSDVNRHGAGRAEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5W3</accession>
    <name>A0A0F4J5W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_22535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949389.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29580">
        <property type="protein sequence ID" value="KJY29580"/>
        <property type="gene ID" value="VR44_22535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.397"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="142"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="39195" checksum="0C6211DA384AA978" modified="2015-06-24" version="1">MTLLAAATNESLADLSNKLVYASMAVYMLAFFAHITEWVFGSRSKVGRTAAALTPAAAAAAGAAPAVQVRTKGGGTAVLDRPKVVTRSASGVRDVPDGPGAAGGTEKGDLYGRIAVSLTVLGFLIEAAGVVSRALSVERAPWGNMYEFNLTFSTVAVGAYLLLLALKKNVRWLGLILVTSVLLDLGIATTWLYTASDQLVPALHSYWLWIHVSTAIFCGAVFYIGAAGAVLYLFRDSYESHLEAGKTPGRFRTSVLERMPSAATLDKFSYRINAAVFPLWTFTIVAGAIWAGDAWGRYWGWDPKEVWSFVTWVAYACYLHARATAGWKGRKAAYLALFAFACWIWNYYGVNILLSGKHSYAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6E1</accession>
    <name>A0A0F4J6E1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000728">
        <property type="protein sequence ID" value="KJY28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949893.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000728.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28471">
        <property type="protein sequence ID" value="KJY28471"/>
        <property type="gene ID" value="VR44_25275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1152"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="902" mass="96198" checksum="15F07F55553D12A2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6I2</accession>
    <name>A0A0F4J6I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000646">
        <property type="protein sequence ID" value="KJY29393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949487.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000646.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29393">
        <property type="protein sequence ID" value="KJY29393"/>
        <property type="gene ID" value="VR44_23070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.554"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15328" checksum="267A5C138A5EE159" modified="2015-06-24" version="1">MEVHEVTLPVTGTPEGAARARRTVMDEVSGWCRGAVTNELHGAEAVAGELLANAVRHGGAGTASITARLRGDRLRFEVRDQSSAVPRKLAGHPDAEHGRGLLIIAALADEHGVEQGSSGKSCWAEFDLAARPTTSVFPQPLDQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6N6</accession>
    <name>A0A0F4J6N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_22830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000640">
        <property type="protein sequence ID" value="KJY29484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29484">
        <property type="protein sequence ID" value="KJY29484"/>
        <property type="gene ID" value="VR44_22830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.498"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21183" checksum="912160AEEB6E9691" modified="2015-06-24" version="1">MLRIMKEDLDVVVAQDPSMRNRREALLHAALPALWAHRVAHRLHRRGMRMTAQLIAWQARRKTSVEIHPGAVLGRRVFIDHGAAVVIGETAVVGDDVTIYHQVTLGAVGWWSDNKRPAGERRHPVVGHNVVLGTNATVLGPVTIGEHAVIGAQALVNKDVPPGARVLAATAVIKAVGEQPQPMEDLYAVTASAGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6T7</accession>
    <name>A0A0F4J6T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949411.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29539">
        <property type="protein sequence ID" value="KJY29539"/>
        <property type="gene ID" value="VR44_22645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.461"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11744" checksum="7F429BD1BD7B27E2" modified="2015-06-24" version="1">MNGRSRRGSGAVGPADAHTDRASFPRIPRGVMRIRSAVTASVLAAGILLGGAGAALANEGVDIDYFSGGHKAYSSNCSSFAAVPHNLPSFAGPVYSSNCAKEGEKEWLKGSHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W8</accession>
    <name>A0A0F4J6W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949383.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29574">
        <property type="protein sequence ID" value="KJY29574"/>
        <property type="gene ID" value="VR44_22495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.389"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="20826" checksum="FAA3AD9C9FF8C374" modified="2015-06-24" version="1">MATPRTPRGKWIEEGLRALAEGGPEAVRIESLAQALGVSKGGFYGYFRNRDALLGEMLDTWEHEAAQAVIEQTEGDGADDARAKLDRLFTIVAESGGGPVRGVPIELAIRDWARRDEAVAERLRRVDDRRMDYLRSLFSSFCPDPDEVEVRCLLVFSLRIGGEFIAAGHGGRTRAEVMTLTKHWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7D5</accession>
    <name>A0A0F4J7D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949145.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30085">
        <property type="protein sequence ID" value="KJY30085"/>
        <property type="gene ID" value="VR44_21255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8975"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="14264" checksum="496068DBECAA1EA6" modified="2015-06-24" version="1">MLRRLVAGLGALALVVEAAVLVVVHLVLGRTTADQSMSIQGSDPDLMSKATYGLGAAIGAFLLLTGVLLAVAAVRDRPPGRTARVVLVAAAVTHGVLGALAAALVGWGAFAATMAVLCLIAGTLTLYADGVPERRLRPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7K1</accession>
    <name>A0A0F4J7K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949036.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30377">
        <property type="protein sequence ID" value="KJY30377"/>
        <property type="gene ID" value="VR44_20650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8845"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="200"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="43279" checksum="2D3DA7150A48DF7F" modified="2015-06-24" version="1">MYRLLRAPLRPVTYSRWLHLCVPLLLLALWMFINPRWPWMPLLIVIPFGFVPWVRLAEGLQAQFLLTPRVREGAEDGEAGDNGIGAAVSARWADRWRTVLWLEIRLVVSGAAMFATVWLPVVTVELIALALGHPLNADPLVPFAPPPWAAALLAPVPLVVLIVVVVLLGELITAVARRLLGPSAAERLTALEARTEQLLERTRIARELHDSIGHALTVAVVQAGAARAAGDPEFTDRALSAIEETGRAALEDLERVLLVLRESARPASQRPTLAEADRLLESARASGAPVEAELSGALEDLPGPVTREGYRILQEALTNVLRHCGPVPVRVRVEMADGRLELEVTNPLPERPSFSTGGGSGLRGIRERASLLGGEAETGPHQGGWRVRARLPLERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7S0</accession>
    <name>A0A0F4J7S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000580">
        <property type="protein sequence ID" value="KJY30250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30250">
        <property type="protein sequence ID" value="KJY30250"/>
        <property type="gene ID" value="VR44_20875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8905"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7761" checksum="C563D3B7FEAAB225" modified="2015-06-24" version="1" fragment="single">LEQSMRSADVGSNYELVRRLDPYVDPAVVDRDELRRQVEAGIQQALPELVPYRETIVSLFADYRDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7T7</accession>
    <name>A0A0F4J7T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949267.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29864">
        <property type="protein sequence ID" value="KJY29864"/>
        <property type="gene ID" value="VR44_21885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.257"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="29308" checksum="E591657CB70AC1F3" modified="2015-06-24" version="1">MAEFPEGTPCWVDAMFTDVEAAKEFYADVLGWTFGEASSEYGNYTQAYSDGKAVAAVVPPMPGADAPSQWCLYFASDDATATAEKIKAAGGTLMMEPMRVGTFGTMAIAKEPSGAVFGVWQPGEHKGFEKLGEAGSYAWAEVYTREPGKADPFLERVFPYESRQMDTGGSGSGDQAAAGMDFKVFSVGGADHPVLGRMKMGEEFPPQVPSYVQVYFGVPNCDLAVEKTKARGGQLYFGPMDSPFGRFAALGDPQGAAFAVIDMDTRVGEMPKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J832</accession>
    <name>A0A0F4J832_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949211.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000603.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29934">
        <property type="protein sequence ID" value="KJY29934"/>
        <property type="gene ID" value="VR44_21595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="43066" checksum="87DE035AAD398ADF" modified="2015-06-24" version="1">MSEAAVLPQPFGEGFAQDPYGVYARLRAQGSVHRVALPDGAPVWLVTHEADVRAGLADGRFSVDKRHSRGGFQGFSLPPALDANLLNIGPEDHLRLRRLVARGFTPRHVERMRTAVQAAVDALADRFTARLEADGVADVVDGLARPLPLKVIGDLLAVPEGEYGRFAGWIGSMLAPGSREELAGAVRSVHAYLVELVAARRAAPGDDVLSGLIAARDSGDRLSEDELVSLAFLILMAGSETVQHLISGGLLTLLTHGEQRAALRERPGLLPEAVEELFRYAVPNHTAIRRFPTEPVEIGGVRIPAGDTVMFSIASAHRDPARYPDPDRFDIGRADKAHLALGHGVHYCLGAPLARTQVTLALGTLLRRLPELRLAVPADGLEWSTTFRFRALRALPVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J866</accession>
    <name>A0A0F4J866_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000669">
        <property type="protein sequence ID" value="KJY29141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29141">
        <property type="protein sequence ID" value="KJY29141"/>
        <property type="gene ID" value="VR44_23640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="11328" checksum="E8088C334A95E7F3" modified="2015-06-24" version="1" fragment="single">AVANGHRVLAVVRGSAVNQDGASNGLTAPSGRAQQRVIRQALESAGLGPADVDAVEAHGTGTRLGDPIEAQALLATYGQGRAAGQPLWLGSVKSNIGHTQAAAGVAGVIKMVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8J3</accession>
    <name>A0A0F4J8J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949158.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30068">
        <property type="protein sequence ID" value="KJY30068"/>
        <property type="gene ID" value="VR44_21325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8990"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="12359" checksum="37F21431D31A04A7" modified="2015-06-24" version="1">MTATGTIDRPLTHDPLKQAPMSPYATTSEQPHGSATADFITTGAITSRQNRTREMQLIPEALARAHMDDRLREVDAQRHAVRLVAARRMQRKAERVSMRARRALAMAVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8U4</accession>
    <name>A0A0F4J8U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30224">
        <property type="protein sequence ID" value="KJY30224"/>
        <property type="gene ID" value="VR44_20890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7947" checksum="D8137D79ECAD7193" modified="2015-06-24" version="1" fragment="single">MTTGWTPHPSQPEHLPELDVPPPGRQRRWTVLLRFLLLLPQFIVVAVLGIAAFFVTVVGWFAALFTGRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8X9</accession>
    <name>A0A0F4J8X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949099.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30203">
        <property type="protein sequence ID" value="KJY30203"/>
        <property type="gene ID" value="VR44_20995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8929"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7027" checksum="1AD23FEA5D018EDA" modified="2015-06-24" version="1">MKRTSAAGPAGRPQDRPAPGGQPPAPPATGESGGGPEERERAAHERAVEREAEDGAGGAVPATPPPAEPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9A6</accession>
    <name>A0A0F4J9A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949413.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29541">
        <property type="protein sequence ID" value="KJY29541"/>
        <property type="gene ID" value="VR44_22655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.463"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="38347" checksum="81F1CB8043B347F6" modified="2015-06-24" version="1">MSGNQNYINHVALVLDASSSMSHLSSKVVEVADQQIAYLARRSQELDQETRVTVYVFANTVECVIYDKDVLRMPSLKQLYRVGGMTALLAATLKSQRELAQTAQLYGDHSFLTFVLTDGQENASHRCPDAPSRDPRTLVDALATMIETQQDNWTLAVLVPDQMGKREAMQCGFPKDNIAIWDATSTRGLEEAGQVIQEATEKFMVGRTKGIRGSRAVFSTGADAVNKETIKAAGLTPVDQARYELIAVDRVAGIREWVVECGHVYRTGGAYYQLSKSEKVQARKQIAVVEKKTDRVYTGPEARALLGLPDAEVRLKPDQNDEFTIFVQSTSVNRKLVANTRLLLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9K8</accession>
    <name>A0A0F4J9K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948976.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6984"/>
    <dbReference type="EnsemblBacteria" id="KJY30479">
        <property type="protein sequence ID" value="KJY30479"/>
        <property type="gene ID" value="VR44_20330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8775"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="25760" checksum="5FC75AF8355571D2" modified="2015-06-24" version="1">MSTTEQRVAIVTGAARGIGAATALRLAAEGRAVAVIDLDEAACKDTVEAITAAGGKALAVGCDVSDAAQVEAAVERVASTLGAPTILVNNAGVLRDNLLFKMSDTDWDTVMNVHLRGAFLMARACQKHMVEAKFGRVVNLSSSSALGNRGQANYAAAKAGLQGFTKTLAIELGKFGITANAVAPGFIATEMTAQTAARVGMGFEEFQLAAASQIPVQRVGVPADVANAIAFFTGEAAGFVSGQVLYVAGGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9R0</accession>
    <name>A0A0F4J9R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948975.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6983"/>
    <dbReference type="EnsemblBacteria" id="KJY30478">
        <property type="protein sequence ID" value="KJY30478"/>
        <property type="gene ID" value="VR44_20325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8774"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="26400" checksum="E4EE778B975C3088" modified="2015-06-24" version="1">MTYNGTDSGKVALVTGASRGIGYGIAEALVARGDRVVITGRNEDALKEAVDKLGADRVIGVAGKAHDEAHQAVAVDRAMEAFGRVDFLVNNAGTNPVFGPIADLDLQVARKVFETNVISALGFAQRTWHAWQKDNGGAIVNIASIAGVSASPFIGAYGMSKAAMINLTLQLAHEMAPRVRVNAIAPAVVKTRFAQALYEGREQEASAAYPLGRLGVPEDIGGAAAFLTSAQAEWITGQTLVVDGGMFLNAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAC6</accession>
    <name>A0A0F4JAC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948868.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000545.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30703">
        <property type="protein sequence ID" value="KJY30703"/>
        <property type="gene ID" value="VR44_19730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8566"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="18560" checksum="D5A383E7E9BC2A54" modified="2015-06-24" version="1">MLGTVLMVMYGVRYPGADQKECCWEQDATPEWAASVTGLRVPDTAVDRRAGLHSNMQYDVVLLAFTVRTEEADKFLEPLRRQGTQMAHNRHPEAPGYTRGDGFSHLGLPEPETLVDGMRITSVCPGETKTPESGALRLCAKIQAHEFQPGTTRIYVRADSDATIEKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAJ7</accession>
    <name>A0A0F4JAJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31397">
        <property type="protein sequence ID" value="KJY31397"/>
        <property type="gene ID" value="VR44_18195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8186"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="11820" checksum="92D7433EF8D248E3" modified="2015-06-24" version="1" fragment="single">GTGAPASPAPGAPESPQAPQSPPASSPSSSPSPTASPELGSRVLEGLGSEGFLEDKLGAAGATAAQARTVRIVFRTSNVIVTVEYSVQPSGPGKVPPAAETQDKARQLAEALAERFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB85</accession>
    <name>A0A0F4JB85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000479">
        <property type="protein sequence ID" value="KJY31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948495.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000479.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31627">
        <property type="protein sequence ID" value="KJY31627"/>
        <property type="gene ID" value="VR44_17770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8050"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="26331" checksum="04C87682D8280970" modified="2015-06-24" version="1">MSDVGTAEHDDPAGATRDTWGRHLSHPASEPVGMPHVIRDGSVPLVPVPPQPEAPDHWTPEQVARFQEYHERYAEKFLWYADARLPSRFDAEDAVHSTFEYVVEQWPRVTTMEFPSAYGWTVLRSRIADLHREGSRIGPVDDERLQEEIGQRPVGDHGEEIVNLMSLLEEIRELPERQEQALVLDALGVPVEEMAELMGIKEESARMNLKRAKARLKRRLDAEGWRRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBX4</accession>
    <name>A0A0F4JBX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948993.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000562.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30456">
        <property type="protein sequence ID" value="KJY30456"/>
        <property type="gene ID" value="VR44_20405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="28862" checksum="F3612E2794F527A5" modified="2015-06-24" version="1">MRIRIIDAFTDRPFHGNPAGVLLLDGPFPPDTWLQQVATEVNLSETAFAHPLPPGGDADWALRWFTPVAEVDMCGHATLATAHALATSGLAEGLIRFTARCGILTAEVAEDGTITMDFPTSSLTPVEADPEIARALGAGIKSVHDTSAHIGDLVVELADERTVRELSPDFAALRGHSRRGVIVTAPAEDPARGYDFVSRGFFPALGIEEDPVTGSAHTALAPFWAARTGRTEMTGLQGGTRTGLVRVRLAGERTLLTGHAVTVIDGELRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCL5</accession>
    <name>A0A0F4JCL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_16655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948288.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32097">
        <property type="protein sequence ID" value="KJY32097"/>
        <property type="gene ID" value="VR44_16655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7764"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="411" mass="44337" checksum="B7B3419C6D8C8F62" modified="2015-06-24" version="1">MTTAGAVETVFRMESARIIAGVTRIVRDVGIAEELAQDALVAALEQWPVSGIPDRPGAWLMATARHRAVDLVRRRETYARKLAEVGRTLEDAPPPAEPADPDDIDDDLLRLVFTACHPVLSTDARIALTLRLVGGLTTQEIARAFLASEPTVAQRVVRAKRTLAKAGVPFEVPYGADREQRLASVLEVIYLIFNEGYAATAGDDLLRPALCEDALRLARQLAALMPDEPEAHGLAALLEFQASRTATRTGPDGEPVLLADQNRSRWNRLLIRRGVEALGRAGTGPYSLQAAIAGCHAAAVRYEDTDWTAIATLYGRLVRLLPSPVVELNRAVAVSMAEGPAAALPLVDALAGEPALRSYHLLPSVRGDLLERLGRGAEARAEFEKAASLTRNARERELLLGRAAALPEFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDF0</accession>
    <name>A0A0F4JDF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000468">
        <property type="protein sequence ID" value="KJY31773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31773">
        <property type="protein sequence ID" value="KJY31773"/>
        <property type="gene ID" value="VR44_17505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8063"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="29152" checksum="05CEE85420898DCC" modified="2015-06-24" version="1">MFDSCGAPYVVYRRPHPPAVVDYLATQWGRATTRPRILDLGCGPGTLTLDLAERGAAVTAVDVSEEMLAAGRDWAQARNIKSVTWKRADATDAAILAKESGPFHGVTIADAFHWMDRRQVLSSLDQAVRPGGFVAVIGYRAPGTQREWWHALLEQLRLRWLGSVNLAGPATTYVEPDGGHEEILRRSAFSQVSVLRTDYRQTYTLNELVGLQRTYAYSSAATLGDRQAGFEEDLRRTLTAARPDGRFEAVLQAAVIIGRRPADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDL3</accession>
    <name>A0A0F4JDL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948397.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000456.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31909">
        <property type="protein sequence ID" value="KJY31909"/>
        <property type="gene ID" value="VR44_17200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7973"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="19483" checksum="EDFFD96366AB5F9A" modified="2015-06-24" version="1">MKKYAALLRGINVGGKKKVPMAELRSVLEELGHRDVQTYLQSGNAVFSSAGQDPAALARELEAAVESRFGFPVKVLVVDGAYLRAVAEACPFPAAELEGRQLHATFFSEQPAPDRFAAIDPAAYLPEEYRLGDRVLYLYAPGGLGTSELGAALHRPAVLKGVDATTRNWNTVAKLVELTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEC3</accession>
    <name>A0A0F4JEC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948123.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32540">
        <property type="protein sequence ID" value="KJY32540"/>
        <property type="gene ID" value="VR44_15790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7565"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="24373" checksum="1FA5E48C1C8DC942" modified="2015-06-24" version="1">MSTQLLRAVNIMVSRDGIGAGENQRLDQPFGDGLDPAVLFSWAGATASWPNRTEPGGSRGLDDYFTRDWNRNIGAEIMGRNKFTPYRGPWEDHPEWQGWWGDEPPFRTPVFVMTHHLRPPLTLSDTTFHFIDADPATVLSRAREAAQGKDVRLGGGVTTIREFLEADLVDTLHVAVSPVEAGHGIRLWDSPEDLLDRFHLDVVPSPSGVTHHLFWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEF2</accession>
    <name>A0A0F4JEF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000433">
        <property type="protein sequence ID" value="KJY32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948244.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000433.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32179">
        <property type="protein sequence ID" value="KJY32179"/>
        <property type="gene ID" value="VR44_16410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7679"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="31403" checksum="0FE2DBBA0A2DDC78" modified="2015-06-24" version="1">MARRIEEGRPGEAKAVLNPSEPNPLLRFEYDRGSNYEMDTRITLAMAALVPEDELINSDHRMFQIVHLVNEYVWCSMHNELGRVAGALDHDDFGLAARLMARTNSLAELPVQCVRILMDHLPQASFLRMRDHLPANTSGLDSPGGRNLRRVCRAVWKSFEAAMQRGGVTSKDLIEEFAREGGEAPAAWLSGLSTVQTGLHALDCKLMEWNQLHLRLVRQHLGGHPAARTEQAPAAADGPTSLRGEPVNELERLSERSVFPLLWKSVDDAYRQATPDRTPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEL2</accession>
    <name>A0A0F4JEL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000426">
        <property type="protein sequence ID" value="KJY32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32239">
        <property type="protein sequence ID" value="KJY32239"/>
        <property type="gene ID" value="VR44_16315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8801" checksum="CB160F2A22DD078A" modified="2015-06-24" version="1" fragment="single">MELLALRCFQVVARHEHISRAAAELRVAQPSVSRTIARLEAELGVELFERRGRRIRLNRHGAAFLRRVDRALGELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF81</accession>
    <name>A0A0F4JF81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">VR44_14810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947943.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000378.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32987">
        <property type="protein sequence ID" value="KJY32987"/>
        <property type="gene ID" value="VR44_14810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7359"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="349" mass="36227" checksum="BB09059E4027CB8C" modified="2015-06-24" version="1">MPQASTDKTASSRDIGIDLGTANTLVYARGHGIVLNEPSVVAVKAGTTTALAVGTEAKETIGRTPGSITAIRPLKDGVICDYEAAEEMIRHFVRKAVPGRRPRTRMVICVPSGVTPVERRAIVHASTRAGARSVHLIEEPMAAAIGAGLPVAEARGSMVVDIGGGTSEVAVISLGGIVTSQSLRIGGDRLDSAIMDHVRKEHSLLIGERTAEDVKVAIGSAWPVPERPELETRTFTVRGRERVGGMPKTLELTAADVRAALDEPVEAIIAAVRATLEECPPELSGDVMEHGIVLTGGGALLPGLDLRMASATGIPVFVADAPLDCVALGSGRCVEDLDALGSLLSPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG19</accession>
    <name>A0A0F4JG19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15265</name>
        <name evidence="3" type="ORF">VR44_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948029.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000059_gene2729"/>
    <dbReference type="EnsemblBacteria" id="KJY32748">
        <property type="protein sequence ID" value="KJY32748"/>
        <property type="gene ID" value="VR44_15265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32749">
        <property type="protein sequence ID" value="KJY32749"/>
        <property type="gene ID" value="VR44_15270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7389"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="53" mass="6007" checksum="19A7750A4DB9726A" modified="2015-06-24" version="1">MVPLLLVLLLALILFGAGFALKVLWWVAIAVLVIWLLGFVARPRTGGGRWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGR6</accession>
    <name>A0A0F4JGR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylhydantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_16505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000435">
        <property type="protein sequence ID" value="KJY32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948261.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000435.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3668"/>
    <dbReference type="MEROPS" id="M38.973"/>
    <dbReference type="EnsemblBacteria" id="KJY32166">
        <property type="protein sequence ID" value="KJY32166"/>
        <property type="gene ID" value="VR44_16505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7700"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="56"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="466" mass="50659" checksum="1687CC371B8BF024" modified="2015-06-24" version="1">MSTRTLIRGGLVVTASDELHADVLIEDGRVAALAATGSAAAAAWTADRTIDASGKYVIPGGVDAHTHMELPFGGTAASDTFETGTRAAAWGGTTTIVDFAVQSVGRSLREGLDTWYDKADGNCAIDYAFHMILSDVNEHTLKEMDHLVGEGVTSFKLFMAYPGVFYSDDGQILRAMQRASSNGGLIMMHAENGIAIDVLVEQALARGETDPRHHGEVRKVLLEAEATHRAIQLARVAGSPLYVVHVSAEEAVAELAAARDKGLPVFGETCPQYLFLSTDNLAEPDFQGAKYVCSTPLRPKEHQAALWRGLRTNDLQVVSTDHCPFCFRGQKELGRGDFSKIPNGLPGVENRMDLLHQAVLDGHITRRRWIETACATPARMFGLYPQKGTIAPGSDADIVLYDPHAEQVISAETHHMNVDYSAYEGRRITGRVDTVLSRGELVIDRREYTGRAGHGAFVHRSTCQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGW1</accession>
    <name>A0A0F4JGW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">VR44_14785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947945.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2603"/>
    <dbReference type="EnsemblBacteria" id="KJY32983">
        <property type="protein sequence ID" value="KJY32983"/>
        <property type="gene ID" value="VR44_14785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7353"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24419" checksum="E53476F1523A90D9" modified="2015-06-24" version="1">MVNTQMQNNFSASGLYSGPQVDNRYVVPRFVERTSQGVREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISIYINSPGGSFTALTAIYDTMQFVKPDIQTVCMGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSGGTGREQLSDLEIAANEILRMRDQLETMLAKHSTTPIEKIRDDIERDKILTAEDALAYGLIDQIVSTRKMNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH26</accession>
    <name>A0A0F4JH26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000374">
        <property type="protein sequence ID" value="KJY33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33109">
        <property type="protein sequence ID" value="KJY33109"/>
        <property type="gene ID" value="VR44_14510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7162"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6587" checksum="4D0E1D45EB192400" modified="2015-06-24" version="1" fragment="single">ALIDGRHILLVDADQAEGKAIGVTGTPTYVIGGERLDGGKSQEGLRARIEEIADRLLAEGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH34</accession>
    <name>A0A0F4JH34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947769.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33500">
        <property type="protein sequence ID" value="KJY33500"/>
        <property type="gene ID" value="VR44_13815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7042"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19041" checksum="EF2C6FD0A72EC598" modified="2015-06-24" version="1">MPQRGAGERRIVLVRHAEAVPKHVTEDFDRALSDRGSHDAPLAGDWLERSGFAVDLALCSPARRTRQTWQLMLPRLSQPPPTVYQDRLYEAEAHDLLSAVRGVAAEVTGLVLVVHNPAVHDLAKNLCDGGPEPLVGRLRTAFPKSAVAVLTFDGGWGDVGPRAARLAAFWAPGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJV4</accession>
    <name>A0A0F4JJV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="11" type="ORF">VR44_14285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000368">
        <property type="protein sequence ID" value="KJY33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007263048.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3345"/>
    <dbReference type="EnsemblBacteria" id="KJY33256">
        <property type="protein sequence ID" value="KJY33256"/>
        <property type="gene ID" value="VR44_14285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7204"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="23423" checksum="640DE8EA47A82B94" modified="2015-06-24" version="1">MNQKRPKVKKSRALGIALTPKAVKYFEARPYPPGEHGRGRKQNSDYKVRLLEKQRLRAQYDISERQMARAYDRAKKAEGKTGEALVVELERRLDALVLRAGIARTIYQARQMVVHGHIEVNGGKVDKPSFRVRPDDVITVRERSREKHPFQVAREGGYAGEGETPRYLQVNLKALAFRLDRDPNRKEIPVICDEQLVVEYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKE2</accession>
    <name>A0A0F4JKE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34243">
        <property type="protein sequence ID" value="KJY34243"/>
        <property type="gene ID" value="VR44_12330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6450"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="24562" checksum="008AFB2E552D7B1A" modified="2015-06-24" version="1">MRFGERPAELGGGPAAQRTAAPDPALGGQHRQDAAGQARSGLVRLPRRHDELLAQPGLGRGELGGGGLAPPREQGEDGLLGVREPARVVAELLAQHLEEVAAFPGRDGTGGGGVDHGGQGARHDEHGAAHAQHPHQGVVGVEGPLHLGHRRGDQAGGQAEVDAGRVRGVQGDQRVDDLLGRLGPGARGEPVAGGEQPAAVLVGDLRPGRIHVRCRVAGSRPPWAVPSDRSGQDRVGDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN53</accession>
    <name>A0A0F4JN53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster insertion protein ErpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030029080.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5109"/>
    <dbReference type="EnsemblBacteria" id="KJY35797">
        <property type="protein sequence ID" value="KJY35797"/>
        <property type="gene ID" value="VR44_09180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5100"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12602" checksum="102760C3ED661526" modified="2015-06-24" version="1">MSVQDDKTTVSDGILLSDAAAEKVRTLLEQEGRDDLALRVAVQPGGCSGLRYQLFFDERSLDGDVVKDFDGVKVVTDRMSAPYLGGASIDFVDTIEKQGFTIDNPNATGSCACGDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN63</accession>
    <name>A0A0F4JN63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_09145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000198">
        <property type="protein sequence ID" value="KJY35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813652.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5115"/>
    <dbReference type="EnsemblBacteria" id="KJY35807">
        <property type="protein sequence ID" value="KJY35807"/>
        <property type="gene ID" value="VR44_09145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5093"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="575" mass="63827" checksum="EA3B677CF1A471C9" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNS8</accession>
    <name>A0A0F4JNS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_10130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947084.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3213"/>
    <dbReference type="EnsemblBacteria" id="KJY35479">
        <property type="protein sequence ID" value="KJY35479"/>
        <property type="gene ID" value="VR44_10130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5626"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11146" checksum="36962382B34AC4C9" modified="2015-06-24" version="1">MTVQQEAPAGGSGGAGESLEVWIDQDLCTGDGICVQYAPEVFELDIDGLAYVKSPEDELLVEAGATTPVPLPLLQDVVDSARECPGDCIHVRRVSDGVEVYGPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP08</accession>
    <name>A0A0F4JP08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946856.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35915">
        <property type="protein sequence ID" value="KJY35915"/>
        <property type="gene ID" value="VR44_08885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4945"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="17466" checksum="6D988E175F1403DF" modified="2015-06-24" version="1">MPQVVVGVGGGLGGLGVLHRAAVEARLRRVELCAVLAWQAPDGGPGSRTSCGAPVLALCRSAAAHRLREVLGTAFGAGAPDLTVTGLTVRGTAGAALVDVARDPDDLLVVGSGPRGPLRRLLRPSVARYVLAHAACPVLTVPPSPLQAEYEAVHRRNSWRLPLDARELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP10</accession>
    <name>A0A0F4JP10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35579">
        <property type="protein sequence ID" value="KJY35579"/>
        <property type="gene ID" value="VR44_09880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5523"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="46344" checksum="E99DE055CBC8FF1A" modified="2015-06-24" version="1">MLVMGDGGLPFFLVRRLPERELPGVVPGRCRHGAVGGVLTRRGRGLRSGGGGGPLREAVPVRPARCRGRGGPLLRLGAGAFGLRLRRPRPLVPGRGLRRAVAVGGLDVRGGLQHGLGLRPGLGVALGQRGPDTGTAQHPRPASRRPGPVRPGGTAARQHAGAQRRLGRGRHVLRTRPGRHLGRRPGGGSTARQRHGSLTPARVGPADPELPGPAGHLTAGPGIRTNPGTSTSPAARQVGRQRPVPGRRGLLVPVQGVRELPLGRRPRIRPGVRVGVVLRVLLLRVPHMPRVPRVLSLPRRLAVLPVLHMRHVLRRPVRARVGSQAEARLRLDLRFRLPLRALGPRAAVELRVRLRLGRLDAGIGPRAGAAAAVSAAGPCAGAPPASGHWAGIVQVPVALGSVLPDEPSGMIIGGGTKPCPGAASGSPVSSASSMSCGSCTKAVASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP27</accession>
    <name>A0A0F4JP27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH:ubiquinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_08525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946787.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene941"/>
    <dbReference type="EnsemblBacteria" id="KJY36127">
        <property type="protein sequence ID" value="KJY36127"/>
        <property type="gene ID" value="VR44_08525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4768"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="139"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="56389" checksum="0205197AFA9D8929" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPC5</accession>
    <name>A0A0F4JPC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">VR44_09720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947013.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35603">
        <property type="protein sequence ID" value="KJY35603"/>
        <property type="gene ID" value="VR44_09720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5444"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26325" checksum="578845E676846898" modified="2015-06-24" version="1">MVHVKTDEAIDEMRAAGRVVAHALTAVREAARVGVSLLELDAVARAVLREARATSPFLGYRPHFAPVPFPAVVCASVNDAIVHGIPDGYRLRDGDLVSIDCGARLRGWCGDAAVSFTVGRARPADLRLIATAEAALAAGIAAAVPGNRIGDIAHAVGSVCRAAGYGIPEGFGGHGVGRSMHEDPGVPNEGPPGRGMRLRPGMVLAIEPMLIAGGGDDYVCDPDGWTLRTTDGSRAAHVEHTVAITAGGPRILTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPV7</accession>
    <name>A0A0F4JPV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946912.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35788">
        <property type="protein sequence ID" value="KJY35788"/>
        <property type="gene ID" value="VR44_09205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5105"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="28533" checksum="9706E679EA201C35" modified="2015-06-24" version="1">MGHWWVRNIVEPGKLPLLLALLSFVLSFLVTRVITRLIRAGRGPFKNITPGGLHVHHVVPGVVLVIIGGFGAVGSGGHSFGAGLSAVLFGLGAGLVLDEFALILHLDDVYWSEQGRKSVEVVVLTAAVVALVLGGFLPFGVNELSPGERHSRGIVVMNTATNFFLALVALWKGKPRTAVFGTVIPFVALIGAIRLARPGSPYARRFYANRPRARAKAGLRAFHHDRRWARPRRRFENFISGLSDPERAREREKSGGGSGPGQGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQE0</accession>
    <name>A0A0F4JQE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947188.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35151">
        <property type="protein sequence ID" value="KJY35151"/>
        <property type="gene ID" value="VR44_10685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5884"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470792" evidence="1">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="29434" checksum="FC7C210C1713D6D0" modified="2015-06-24" version="1">MIRINALLPVLAALLVLTACGAPAAKTPVTSPAVDGVRITSVTIPSAPAAPGSGSGSGVPAGDSGISAAYEVTNNGTSALAYTILFDFTTDGGQVMANTQETVRSVGPGATVRGTVRLGAPGPGSSGVTRVKVSRVTKVPAAEAPSASGECPPSGIRITADDGDAAMGLRVVGLRLENCGKRDYALDGYPVLELLDKDRSPVEGVRIVQGSGGITTGTGFDEPARPLVLKPGDSALSGLMWRNTTGSGDVVDVPYVRVRAVRGADPVTVTPHLDLGTTGLLAVRAWTRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRD5</accession>
    <name>A0A0F4JRD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="5" type="ORF">VR44_10105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947081.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3217"/>
    <dbReference type="EnsemblBacteria" id="KJY35476">
        <property type="protein sequence ID" value="KJY35476"/>
        <property type="gene ID" value="VR44_10105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5621"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005024456" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023232870" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="52"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="29967" checksum="70F72877E25EFB73" modified="2015-06-24" version="1">MEANNRGTGRLPAAFLTPGSSSFMDFLGAHAPEMLPGNRKLPEGIVEAPHGTTIVAATFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGATLSLEGKANRLSTMIRSNLGMAMQGLAVVPLFAGYDEAKEKGRIFSYDVTGGRSEEHGYAATGSGSIFARGSMKKLYRPDLTEEQATTLVVQALYDAADDDSATGGPDLYRHIYPIVTVITDEGFRRLDEDESQALARKVTDRRLQEPDGPRAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRM8</accession>
    <name>A0A0F4JRM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000212">
        <property type="protein sequence ID" value="KJY35591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947030.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3693"/>
    <dbReference type="EnsemblBacteria" id="KJY35591">
        <property type="protein sequence ID" value="KJY35591"/>
        <property type="gene ID" value="VR44_09810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5462"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="41563" checksum="04E4A34359C48ECE" modified="2015-06-24" version="1">MTTYRDFSLTHRGSARATVLRTIGTRERRSHLTAPRVPTVGIDIGGTKVMAGVVDADGNILEKIRTETPDKSKSPKVVEDTIAELVLDLSDRHDVHAVGIGAAGWVDADRSRVLFAPHLAWRDEPLRDALQSRLAVPVMVDNDANTAAWAEWRFGAGRGEDHLVMITLGTGIGGAILEGGQVKRGRYGVAGEFGHMQVVPGGHRCPCGNRGCWEQYSSGNALVREARELAAADSPVAHDIIARVGGNVHEITGPLITELAREGDAMCVELLQDIGQWLGVGIANLAAALDPSCFVIGGGVSAADDLLIGPARDAFRRHLTGRGYRPEARIAKAQLGPEAGMVGAADLARLVARRFRRATRRRVERYERYAQFGRRGAAGPEDQDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JST7</accession>
    <name>A0A0F4JST7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946848.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36006">
        <property type="protein sequence ID" value="KJY36006"/>
        <property type="gene ID" value="VR44_08845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5015"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="29" mass="3173" checksum="F52E2EF33FB0BEFC" modified="2015-06-24" version="1">MGTENVVGIIIAVCLAGYLVLAYLFPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT38</accession>
    <name>A0A0F4JT38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36979">
        <property type="protein sequence ID" value="KJY36979"/>
        <property type="gene ID" value="VR44_06790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9014" checksum="B6CFDDA19504D047" modified="2015-06-24" version="1">MHSIQVTVRSGKGLHARPASLFVQAAARQPATVTVGRPGQAPVDSRSLLSVLALAAGHGETLELSASGDGALESLEALASLLASDLDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT54</accession>
    <name>A0A0F4JT54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_05785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946276.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37370">
        <property type="protein sequence ID" value="KJY37370"/>
        <property type="gene ID" value="VR44_05785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1972"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26211" checksum="9A3AA822680F432E" modified="2015-06-24" version="1">MTAPVFVVEEVPAGPEFVLEGPEGRHAVSVKRLAPGEDVVLTDGRGRWAEGVVKAAEGKDRLVVMDLHGIQEEPEPAVRITVVQALPKGDRGEVAVETMTETGVDAIVPWQASRCITQWRGERGAKSLAKWRATARESGKQSRRVRFPEVGEALSTKQVAALLAGADLAMVLHEDREAASEPLATAALPESGSVVLVVGPEGGVSPEELAAFAEAGARPYRLGRSVLRTSTAGTAATAVLLARLGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUI3</accession>
    <name>A0A0F4JUI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946600.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36636">
        <property type="protein sequence ID" value="KJY36636"/>
        <property type="gene ID" value="VR44_07540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3985"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6615" checksum="24E1B45AF0D02A2E" modified="2015-06-24" version="1">MGIKEQFEDKAQELKGKAQKAQQGAKEQASSRSQQAKAKKPQAQQPLDDIRDEADDSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV40</accession>
    <name>A0A0F4JV40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_05415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37608">
        <property type="protein sequence ID" value="KJY37608"/>
        <property type="gene ID" value="VR44_05415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1719"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="292"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="457" mass="48758" checksum="680867447C6FFD3A" modified="2015-06-24" version="1">MDWLVSVSHVRVLADGEVLFHDGDEATCFHVLVSGGLVVTKVVDGREEVLTRHSTEEETAAADEHDGKPTAAHRFTGELPLLTDGSYVATASASGPETTVVAYPKPVFFEMLTRCNGVAAVLIPVLAWRIKSSEVQARKRATVEALGTLAAGLAHELNNPAAAVARAAQELVPALERLTATAYGWGAAATAAERDVLEHLAGELDRLPPPETTDPLAQADAEEEITDWAEEAGAGRPELLGAGASDLGLELSWLLERLEGIGEAALPDALDHLAALLEARSLAAELRAAGPRISQLVAATRDYANLDRAPEQRFAVTDGLENTLVVLRSKLTGITIVRAYDPDLPELTGYPGELNQVWTNLVDNAAEAMEGAGTLTLRCYAEGVCMVVEITDTGRGIPEDVLPRIFEPFYTTKDVGKGTGLGLHLSYRIVTQRHHGSITARSRPGETRMLVRLPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW50</accession>
    <name>A0A0F4JW50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946051.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37953">
        <property type="protein sequence ID" value="KJY37953"/>
        <property type="gene ID" value="VR44_04585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19427" checksum="D4CA8F063D1A28B5" modified="2015-06-24" version="1">MSSSTSSLPERIELPGEGLVLRDWAEGDLAAMPELFDHPDIAYWTPIVSPFDEAAARARLVRARQLRQEGTTILLAITVDGGAPLGEVMLRRAPEGTEIGYAVGPAHRGQGLAARAVRVMAAYAFEQWGVRQVILELEAENAASVAVAGKAGFRLLDVPPITGEEKGRPYVLQTWGLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWG3</accession>
    <name>A0A0F4JWG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38078">
        <property type="protein sequence ID" value="KJY38078"/>
        <property type="gene ID" value="VR44_04345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.437"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="503" mass="53693" checksum="662F4307B7783C87" modified="2015-06-24" version="1">MGGASVSSDLNSPFRTKTVEQSIRDTEEPEHALRKSLSAWDLTVFGVGVIIGTGIFVLTGIAARNNAGPATALSFVVSGVVCALAALCYAEFASTVPVAGSAYTFAYASIGELPAWIIGWDLVLEFALGTAVVAVGWSGYVRHLMHTNLGWDMPVALSGPDAGGHFDLLAFLLVLALTAILVVGTKLSARITAVVVAIKVTVVLLVIIAGAFFIKADNYSPFIPPAKPQPGGSGWTAPLVQLIFGFQPTNFGVMGIFTAASLVFFAFIGFDVVATAAEETKNPQRDMPRGILGSLLICTLLYVAVTIVVTGMQYYADMSPTAPLAEAFKSVNQPFFSGAISLGAAVGLITVSMILLLGQTRVFFAMSRDGLLPRTFSVTHPKYRTPYRATLLLGGIIAIVAGFTSLEKLAELVNIGTLFAFVVVALGVIILRRTRPDLHRSFRTPWVPVVPILSIAASLWLMLNLPAETWARFAVWMVIGFVVYFFYGRGHSRLGRSGQDAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWI8</accession>
    <name>A0A0F4JWI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000062">
        <property type="protein sequence ID" value="KJY38495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38495">
        <property type="protein sequence ID" value="KJY38495"/>
        <property type="gene ID" value="VR44_03480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7914"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17015" checksum="A71A5B63201AE98F" modified="2015-06-24" version="1">MGPTSSAKSWLITIFALASTSRSGPASRGSMLLYATLNSTVKTPPTPTTTYRYQRLRCPASALYGLGLAAFSANVGLYNITANSYLQHITPAPLLGRVNAAFMWVCLGVIPLGALLGGALGSQLGLRTTLWICVLGTWSASLFVLFSPLRTMRDMPVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXU2</accession>
    <name>A0A0F4JXU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946113.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000090.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37816">
        <property type="protein sequence ID" value="KJY37816"/>
        <property type="gene ID" value="VR44_04905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1066"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="30114" checksum="382EA594FF367D67" modified="2015-06-24" version="1">MTKPTTPTTTAPTTGTLDVPGATLYYERRGSGPVLLLIPGGGADAGLYAGMAPALAAAGRTVVSFDPRGQSRSTLDGPAADQRVEDWADDARRVLDLVSPGEPADVLGCSAGAVAALGLLARHPERVRRVVAHEPPLVEVLQDPAPYRTLFADVRELSRTRGPAAATARLAEGLGGEQPQREEPAAGLPPEILEMAPRMYANQPFFLEHVLVPFTGSTPDVPALRAAADRLVLAAGEDSRPIPALHGPAARLSDLTGAPFTEFPGGHVGCAEHPAPFATRLLETLTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYC7</accession>
    <name>A0A0F4JYC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042816748.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4912"/>
    <dbReference type="EnsemblBacteria" id="KJY38743">
        <property type="protein sequence ID" value="KJY38743"/>
        <property type="gene ID" value="VR44_03025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7337"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="20274" checksum="C42B85C3F98BF6DB" modified="2015-06-24" version="1">MGVSLSKGGNVSLTKAAPNLTAVIVGLGWDARTTTGVDFDLDASAILTNDQGKVATDSNFVFFNNLKSPDGSVEHTGDNLTGEGEGDDEAIKVNLAGVPADVAKIVFPVSIYEAESRQQSFGQVRNAYIRVVNQADNSELARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYP7</accession>
    <name>A0A0F4JYP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-pyrone-4,6-dicarboxylate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000041">
        <property type="protein sequence ID" value="KJY38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38949">
        <property type="protein sequence ID" value="KJY38949"/>
        <property type="gene ID" value="VR44_02635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6833"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="8323" checksum="6926B41B9D087BE1" modified="2015-06-24" version="1" fragment="single">AYRDVVPFARRVVEEFPDRVLWGTDWPHPNLATHMPDDGLLVDFVPGIAPTPELRQRLLVDNPMRLYWPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZL1</accession>
    <name>A0A0F4JZL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="7" type="ORF">VR44_03565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945876.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5750"/>
    <dbReference type="EnsemblBacteria" id="KJY38426">
        <property type="protein sequence ID" value="KJY38426"/>
        <property type="gene ID" value="VR44_03565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8251"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="99"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="118"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="209"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="37018" checksum="7E5E4BCDD5D25E05" modified="2015-06-24" version="1">MRRYGKHTDEDDIRQRPNPKGNRARTNIRPKHEDASEGFVLTVDRGRLTCLVDDRTVTAMKARELGRKAAVVGDRVSLVGDLSGKKDTLARIVRIEERKSVLRRTADDDDPYERVVVANADQLAIVTALADPEPRPRMIDRCLVAAYDAGLEPLLVLTKSDLTSPDKILEVYSTFGLNYVVTNREELETGDAAARVRERLEGRITAFVGHSGVGKTTLVNSLVAEGRQRATGHVNKVTGRGRHTTTSALALPLPSGDGWVIDTPGVRSFGLHHVDPSRVVLAFPDLVPGTEECPRACSHDEPDCALDQWVADGHADPARLYSLRRLLGTRERREGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0A8</accession>
    <name>A0A0F4K0A8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein VR44_00075</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945258.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene984"/>
    <dbReference type="EnsemblBacteria" id="KJY40062">
        <property type="protein sequence ID" value="KJY40062"/>
        <property type="gene ID" value="VR44_00075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.16"/>
    <dbReference type="eggNOG" id="COG1666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY40062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17914" checksum="9BA6048377D8335E" modified="2015-06-24" version="1">MADSSFDIVSKVERQEVDNALNQAAKELSQRYDFKGTGASISWSGDKILMEANSEDRVKAVLDVFETKLVKRGISLKALDAGEPQLSGKEYKIFASIEEGISQENAKKVAKMIRDEGPKGVKAQVQGDELRVSSKSRDDLQAVQALLKGKDLDFAIQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K104</accession>
    <name>A0A0F4K104_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_00955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945393.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39613">
        <property type="protein sequence ID" value="KJY39613"/>
        <property type="gene ID" value="VR44_00955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2904"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="495" mass="54419" checksum="34944B47B9D0F19E" modified="2015-06-24" version="1">MTQVHEDRPPVLPTQQDEVAAAGSELIGGPAGRHFRPGGHWLAPVRVVVLVALGMFALGMVQKLPCYDWAWFQGAGSQYTHACYSDIPHLYSARGFADGLVPYRDRFPDLAVDPKYGGMQYLEYPVLTGAFMEVASWLTPSSGAIQHREQMYWMVNAGMLMACAAVIAVCVTRTHRRRPWDALLLALAPAFALNATINWDLPAVALAAAAMLMWSRGRPLLSGVLIGLATAAKLYPVLLLGVLFVLCWRAGKWRAFGAALGGAVVSWLVVNLPVMLYAWDGWKRFYVFSQERPIDFGSIWLLISQRTGNPLEGANTYATGLTLLLCLGIGLLALTAPRRPRFAQLAFLVVAAFILANKVYSPQYVLWLVPLAALARPRWRDFLIWQAGELVYFLGIWLYLAYTTSGDKHQGLPLEGYQLAIAVHLLATLYLCAVVVRDILLPERDVVRRDGSDDPSGGVLDGAEDVFVLGDKAKAPRYAAPPEGQRVAWGTDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K174</accession>
    <name>A0A0F4K174_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000005">
        <property type="protein sequence ID" value="KJY39884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39884">
        <property type="protein sequence ID" value="KJY39884"/>
        <property type="gene ID" value="VR44_00485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.96"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="14273" checksum="BC077050E8D731DF" modified="2015-06-24" version="1" fragment="single">MNETPRRVYAEIDLDAVRANVRALRARAPRAELMAVVKSNACGHGALPCARAAQEAGATWLGTATPEEALELRAAGIRGRILCWLWTPGGPWREAVEADIDVSVSGMWALEEVRAAARAAGRTARIQLKVDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1D3</accession>
    <name>A0A0F4K1D3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_02405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39031">
        <property type="protein sequence ID" value="KJY39031"/>
        <property type="gene ID" value="VR44_02405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6770"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="26"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="33450" checksum="0480C8B55143915F" modified="2015-06-24" version="1">MTPEGTHGPEAVTLTMNPTIDLCWEVERLEAIGKNRARVRSVAVGGGGINVARHIARFGGRAIAVHTAGGEVGLRLNRLLDEEGVDHVAVDIAEDTREALVLFETGSRRSYHVVPSGPQLNEGEGERCLEVLERFLGGCPFVVASGSLPGGLRDDYYAAVARRVREAGARLILDTSGPALPAALAEGVFLFRCNRTEAESLVGRPVNSFDDARALNEHLLTTGAAEIAVTTLGALGALCSTSQGHTELYVPPLPGEPLSDAGAGDSMVAALATRLAAGDDPVGACALGVASAAAAMLTPSTESFDVDVARALLPQVRTVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2Z7</accession>
    <name>A0A0F4I2Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001837">
        <property type="protein sequence ID" value="KJY15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15843">
        <property type="protein sequence ID" value="KJY15843"/>
        <property type="gene ID" value="VR44_40755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="6831" checksum="D53F4DDEB500C73E" modified="2015-06-24" version="1" fragment="single">GRAALAGAVAVAACALTGAAVGAVCSRPLVPGRGFAVLGAALGSLLAWVVSASPARAAVSALIGAARAGAPVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I743</accession>
    <name>A0A0F4I743_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001741">
        <property type="protein sequence ID" value="KJY16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16526">
        <property type="protein sequence ID" value="KJY16526"/>
        <property type="gene ID" value="VR44_40405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8021" checksum="0CF0DD52D845B762" modified="2015-06-24" version="1" fragment="single">GAAIAAVNGPEAVVLSGTREAVEGVVALLAAQGVKAKALRVSHAFHSPLMDPMLEEFRTAISGLDFHQPAIPFVSALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8U8</accession>
    <name>A0A0F4I8U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001625">
        <property type="protein sequence ID" value="KJY18089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18089">
        <property type="protein sequence ID" value="KJY18089"/>
        <property type="gene ID" value="VR44_39705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6123"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9058" checksum="3E260D116D479B15" modified="2015-06-24" version="1" fragment="single">PQGRVFLLGDNRGNSADSRFRLRTTPGGTAPVAQVLGVALPQEETLRVGVLYGWLIIVGVLALPASAVLGVVWLLLRRRRAAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAC0</accession>
    <name>A0A0F4IAC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001598">
        <property type="protein sequence ID" value="KJY18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952527.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001598.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18609">
        <property type="protein sequence ID" value="KJY18609"/>
        <property type="gene ID" value="VR44_39525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5994"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16087" checksum="50733D2191A3E827" modified="2015-06-24" version="1">MLNTKRAGRTEPEPREPLAAEYAEDDDYLEPGDAEGFEIHHAICPDCGQSIALVADEELLPEHALCLTPWNPFGLTVCAGTGRPVSDALAAAGLLQSEQPELEAVVHLTLPQGLDWRTQPFSHVGGPGSRPVRLAEAAPLPQKREHAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IC79</accession>
    <name>A0A0F4IC79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001613">
        <property type="protein sequence ID" value="KJY18261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18261">
        <property type="protein sequence ID" value="KJY18261"/>
        <property type="gene ID" value="VR44_39615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6039"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="23214" checksum="291ACA2CB57C23FF" modified="2015-06-24" version="1" fragment="single">MSDAIPPPVHLDKVVDGLAENPALPSELVHRLLGYRKGLGRVAKRPDLSDGVIAQIIATDDHWLTHSLALNRSLPQAFRMILAEHPDPAIRRALVVAADGAPRELFELLLDDSDPQVREHLAASDHMPADLRTRLAADPDPRVRATLAQWWTTAPEPVRRLLLTDPDDSVRAGACATYFRRLPHPVPPADLVADLLADPVTRAGAVRHCSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ID62</accession>
    <name>A0A0F4ID62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_39540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001600">
        <property type="protein sequence ID" value="KJY18601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3295"/>
    <dbReference type="EnsemblBacteria" id="KJY18601">
        <property type="protein sequence ID" value="KJY18601"/>
        <property type="gene ID" value="VR44_39540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5998"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nitroreductase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY18601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="564" mass="59752" checksum="4CAF56F20F105F1C" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH04</accession>
    <name>A0A0F4IH04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001479">
        <property type="protein sequence ID" value="KJY20934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952332.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001479.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20934">
        <property type="protein sequence ID" value="KJY20934"/>
        <property type="gene ID" value="VR44_38495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY20934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="28269" checksum="8B382C6D88160806" modified="2015-06-24" version="1" fragment="single">EDRAPLSVLTMVRGQAWLLPDDGEPALVGPGDVAVVRGPGAYTLADRPDTPVEVTVGPDQRCSTPEGEDLAERLALGVRTWGRPGPGAAVMLSGTYQAPGEIGRLLLGALPAVLVRPAGAADATLIGLLATEVARDEPGQEIVLDRLLDLLLIGVLRAWLAAPGAGAPGWYRAQGDPVVGVALRLLHEEPAYGWTVAELARRAGVSRAALARRFTELVGEPPVAHLTGWRLALAADLLREPDATVGSVARRVGYGSAFALSAAFKRVRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH34</accession>
    <name>A0A0F4IH34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001526">
        <property type="protein sequence ID" value="KJY19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19941">
        <property type="protein sequence ID" value="KJY19941"/>
        <property type="gene ID" value="VR44_38885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5493"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="17744" checksum="6694104B4F5AED4F" modified="2015-06-24" version="1" fragment="single">VPRVRCACGNPLSPPVALQANPKRNGQPWAAYQPSKVVAIAPSETTVDSFVIYDHQDHRWLERGRGAVPKPDKPVPPPPVTTPVPSANPPTGTATSAGPTPPATSSAPPTRKPTGPATHTPPASPSELPSEPPSETATEPYPATPTAPSSAPARTPYAPATPPPPPANPYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHD1</accession>
    <name>A0A0F4IHD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001481">
        <property type="protein sequence ID" value="KJY20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20883">
        <property type="protein sequence ID" value="KJY20883"/>
        <property type="gene ID" value="VR44_38515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5354"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26109" checksum="22395C3C9FF812CE" modified="2015-06-24" version="1">MNPAPYDPYAFEPFAVTVDLAVLTVRGGALHVLLIRRGQEPYAGAWALPGGFVLPRESAETAALRELAEETGLPPALVGALHLEQLRTYSEPDRDPRMRVVSVAFTALVPDMPEPAEEGGGDADRARWVPVGEASGLAFDHGRILADARRRVGSKLEYTCLATAFCPPEFTLGELQAVYETVWGTGLDRPNFRRKVLATPGFVEAVPGGARLTGGRGKPAALYRAGPATPLHPPLLRPTEGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJ35</accession>
    <name>A0A0F4IJ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001434">
        <property type="protein sequence ID" value="KJY22035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5213"/>
    <dbReference type="EnsemblBacteria" id="KJY22035">
        <property type="protein sequence ID" value="KJY22035"/>
        <property type="gene ID" value="VR44_38070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5217"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY22035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="33991" checksum="3E2E0E8B1D8512E1" modified="2015-06-24" version="1">MRDLVKTYPAVRGRRGAPALPETRATDGICLEVRRGEIFGLLGPNGAGKSTLVRQLTGLLRPDAGSVTLLGHDLVRHPERASRLLAYLGQESTALDELTVALAAETTGRLRGLDARAARAARDEVLEELGLTGIAGRPLKKLSGGQRRLACFAAALVGERPVLVLDEPTTGMDPVARRAVWAAVDRRRDRHGATVLLVTHNVIEAETVLDRVAVIDQGKVIACDTPAGLKARVSDEVRLELVWRTAPPLEVPEVAALAPSAAESGRRWVLRLGQDEARAAVAAVTGGPAFAALDDFTLATPSLEDVYLALGGRMKGLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKA4</accession>
    <name>A0A0F4IKA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001470">
        <property type="protein sequence ID" value="KJY21066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952316.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001470.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21066">
        <property type="protein sequence ID" value="KJY21066"/>
        <property type="gene ID" value="VR44_38405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="489" mass="53532" checksum="F0C07A4420C83A14" modified="2015-06-24" version="1" fragment="single">MTENSGTDSFLAARDFLLAHRGQYEAARAGFTWPRPERFNWAFDWFDRIAEGNGADALRIVEEDGTTETVTFDEMRLRSGSAATWLRGQGVAAGDRILVMLGNQRELWEVMLGAMKLRAVVIPATPLLGPADLRDRIERGNVRHVIARVADTPKFDEVPGDYTRIAAGDGVPDGWLRLADMEGADSGFRPDGVTLASDPLMLYFTSGTTARPKLVEHTHASYPIGHLSTMYWLGLRPGDVHLNIASPGWAKHAWSNLFAPWNAGATVFVHNYTRFDAQRLMAEMDRAGVTTFCAPPTVWRMLIQSDLTALRRPPREAVAAGEPLNPEVIERVKEAWGITIRDGFGQTETTLQVGNFPGAEVKPGSMGRPAPGYEIVLLDAVTGKESPDEGELCVDLRRGPAGVMTGYRDDPERTAEAMADGLYRTGDIASRDADGYLTYVGRADDVFKASDYKISPFELESALLEHEAVAEAAVVPAPDALRLAVPKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM53</accession>
    <name>A0A0F4IM53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001410">
        <property type="protein sequence ID" value="KJY22759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952197.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001410.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22759">
        <property type="protein sequence ID" value="KJY22759"/>
        <property type="gene ID" value="VR44_37775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5061"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="157"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY22759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="38794" checksum="65EA236A819309A5" modified="2015-06-24" version="1">MKDLLLIAAFAFGGAVCAGLLGAVALRLLRHRSVAVSMAVVAAVAVTAMLAGTLAVAWAMFLSPHDLSVVTLVAAMAAVVSLATAVLLGRWVVARGRDLARAARDFGEGGSFAAPPARATAELAAVTRELAATSARLAASRERERALESSRRELVAWISHDLRTPLAGLRAMAEALEDGVAEDPARYHRQIRTEVGRLDTMVGDLFELSRIQAGALELTPGRVSLQDLAADALLGADPLARERGVRLCGDGIAPVPVEVDGKEMTRVLANLLVNAIRHTPADGTVAVRVDRHEDSAVLSVTDGCGGIPEEDLPKVFDTGWRGSPARTPPAGAGLGLAIVRGIVEAHAGRARVHNVPGGCRFEVTLPLATAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPU5</accession>
    <name>A0A0F4IPU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001309">
        <property type="protein sequence ID" value="KJY24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951971.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001309.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24022">
        <property type="protein sequence ID" value="KJY24022"/>
        <property type="gene ID" value="VR44_36565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4618"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="15388" checksum="9BE9CE4000AD295C" modified="2015-06-24" version="1">MVTDAEWARIRRGLRFGQVFEGTVVKVPRPGAIGIFVDIGLQVGGFVDVLLLPEQNDDWPEEGTVAEFEIWWADSRRQIRLKPSDSRYLRTDFAEFLALARPDWPFEVGQPVRDPGPSAFDQVRSALRPDGPPAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ06</accession>
    <name>A0A0F4IQ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001412">
        <property type="protein sequence ID" value="KJY22731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22731">
        <property type="protein sequence ID" value="KJY22731"/>
        <property type="gene ID" value="VR44_37810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10442" checksum="C1B3994D1EB9DE81" modified="2015-06-24" version="1" fragment="single">LRDRLARLLERPALWAPVVVVNLSAMTVLCWHQTAMLAAAAPASFSGGAVAGLTTAPDGPGWIAARVVWLPVFAALLVGIARYARRFEVAPAPGRRGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQZ6</accession>
    <name>A0A0F4IQZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001294">
        <property type="protein sequence ID" value="KJY24094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951929.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001294.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24094">
        <property type="protein sequence ID" value="KJY24094"/>
        <property type="gene ID" value="VR44_36335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4518"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="8"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="507" mass="51567" checksum="15DECA98F244F047" modified="2015-06-24" version="1">MTANPVWSVDPRTGKQRERVAVEATAPDVDRAVRAAHAARGALAAAASRTAFLRAAADLLDGAATRIVETADAETALGSARLTGELARTTGQLRAFADVVEEGAYLDVRIDRADPSLTPPRPELRRYKVPLGVVAVYAASNFPLAFSVPGGDTASALAAGCPVVVKAHPDHPATSELCGELLRRAAVASGLPADVVTVVHGFDAGLELVRHPLVAAAGFTGSIRGGRALFDAAAARPVPIPFHGELGSLNPVVVTPAAAAERAEEIGSGLAASVTLGVGQFCVKPGLVLVPEGADGDLLTAALAKQLGQTGPGVLLDHRMRDAFVSGVRERAALPGVTAPVTPGPGGEHTVAAGHLSVAAARLLEGGPYELLLEECFGPVTVVVRYSGAEEAAAVLDRLGGNLSATLQLSRAETEGAPGPAAALIAQVTGLAGRIVVNGWPTGVAVAPAQHHGGPYPAATSHSTSVGGTAIERWLRPVAYQSVPDALLPPELREGNPLGLPRRVTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR35</accession>
    <name>A0A0F4IR35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001226">
        <property type="protein sequence ID" value="KJY24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951739.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001226.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5009"/>
    <dbReference type="EnsemblBacteria" id="KJY24452">
        <property type="protein sequence ID" value="KJY24452"/>
        <property type="gene ID" value="VR44_35330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4178"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24654" checksum="7A1051545AAA2704" modified="2015-06-24" version="1">MTSSDSTQKPPAKDPWDLPDVSGLVVGVLGGTGDQGRGLAYRLARAGQKVIIGSRAADRAETAARELGLGIEGADNAECARRSDIVIIAVPWEGHAKTLEALREDLAGKLVVDCVNPLGFDKQGAYALQVEEGSAAQQAAALLPGSRVTAAFHHLSAVLLQDTSVEEIDTDVMVLGESRADTDLVQALAGRIPGMRGVFAGRLRNAHQVEAMVANLISTNRRYKAHAGLRLTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR76</accession>
    <name>A0A0F4IR76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001212">
        <property type="protein sequence ID" value="KJY24525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24525">
        <property type="protein sequence ID" value="KJY24525"/>
        <property type="gene ID" value="VR44_35090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="363"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="495" mass="48684" checksum="419FD67F1EDE8683" modified="2015-06-24" version="1" fragment="single">MPEESGNGAHEVIVAIGSAHRRPQDTGTDGAFDAEFLAEAAADPSAPVTAGALPHGPAAAETWWEALEDAGVVPARALAPGLFLAVPGPDVELPAQEEAAAAAGAVLRLAPGAAPLLRRLPTGPDALRAAHDSLVRGESDLALAAGPDVRLPGAPDSGDGGYGAVLLKPLAAARADGDRILAVLGADGRWTTTDSGWNLGPGTAAGTGPAATGGDTGGTPGADVPAPEAAAGTGPEAVGVPAPGAAAAAGADVAAGGAPGAPASLWGGAEEALPWMLSAAGPEALRARARQLHEHLTAHAGPDPAAVGRALATTRHHFPHRAVLLGDGRARLLDALAALADGGFATDVVRGTGPAAVRQAAFVLSGIGGQWPAMAAELLDSSPEFRTAALRCEQALAPLTGWLLTDVLRGAPGAPGPDTPDVSIPATFGVQIALAETWLAHGVRPRAYAGHSVGEIAAAHLAGALTLEDAARAVHAWGAALAELAGHGGDMLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRT7</accession>
    <name>A0A0F4IRT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001272">
        <property type="protein sequence ID" value="KJY24188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951882.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001272.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5272"/>
    <dbReference type="EnsemblBacteria" id="KJY24188">
        <property type="protein sequence ID" value="KJY24188"/>
        <property type="gene ID" value="VR44_36080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4456"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26396" checksum="7C0EA50D58639AC2" modified="2015-06-24" version="1">MGVSTSRPDKGIALVTVDFPPVNALPVHGWYELADAVRTAGRDPEVRCVVLAATGRGFNAGVDIKEMQRDTGHSALIGANRGCYEAFAAVYECEVPVVAAVHGFCLGGGIGLVGNADAIVASEDAVFGLPELDRGALGAATHLARLVPQHLMRALYYTSRTATAAELHAHGSVWKVVPRTELSAAALELAAEIAKKDATLIRLAKAAINGIDPVDVRRSYRFEQGFTFEANLSGVADRVRDTFGKAQGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISM2</accession>
    <name>A0A0F4ISM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001135">
        <property type="protein sequence ID" value="KJY25005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951443.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25005">
        <property type="protein sequence ID" value="KJY25005"/>
        <property type="gene ID" value="VR44_33710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3653"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="373" mass="40943" checksum="C6DEFDBD6314BE66" modified="2015-06-24" version="1">MVTDALLGGTEEDPTTDHPDARYAARLAAHGTVSTRLSLLSDRRLGDLVASARPAGSGIGGRTAELDVDGVRVFVKRVPLTDVEIQPENVRSTANLFGLPTFYQYGLGSAGFGAWRELAVHTMTSNWVLAREYEGFPLMHHWRVLPDTPPEGFMDALGGIDGAVAHWDGSQAVRERLEAIGRSSHSLVLFLEHVPQTLGAWLREQRLDAEPTGAGSPYPRVEEALACGAAFMNARGLVHFDAHFDNVLTDGRLIYFADFGLALSSGFELSAAEERFLSDHLAYDRHYIAGHLLRLHLVDRLRGDTERDVFLEDWVAGRRPDGVPPELAAILERHARTAVILRGFHRRMLQESKRTPFPAAELARAEAAGTTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT67</accession>
    <name>A0A0F4IT67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001109">
        <property type="protein sequence ID" value="KJY25200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25200">
        <property type="protein sequence ID" value="KJY25200"/>
        <property type="gene ID" value="VR44_33145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3501"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16538" checksum="6B1DDE337FC01A33" modified="2015-06-24" version="1">MSDPGHENLPDSPPPAGPPAETTGAEPAGGHPHWFDDEAGPVVRPYAMTRGRTRHAAQHRLDLIALVVAEPAADDPVWDLTLSPEHAHILELCRERPQSVAELAAELDLAIGVVRVLIGDLVDDALVHVNRPVPPAELPDESILREVIDGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITL9</accession>
    <name>A0A0F4ITL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25370">
        <property type="protein sequence ID" value="KJY25370"/>
        <property type="gene ID" value="VR44_32635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11615" checksum="0F344E6F35E4C1DE" modified="2015-06-24" version="1">MGTDMSLHPMKPQPEAGPYLSLIDLVVLRLTPVVPAPGSQLQFTAVGPRGTDMVSARVAADAGDTIAPTATVAVMATEILFGICNAFLLHGHVQPQLGMAKWNRHVQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITS6</accession>
    <name>A0A0F4ITS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_36360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001296">
        <property type="protein sequence ID" value="KJY24086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24086">
        <property type="protein sequence ID" value="KJY24086"/>
        <property type="gene ID" value="VR44_36360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4524"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="11">
        <location>
            <begin position="152"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="444"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="631"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY24086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1260" mass="132024" checksum="71E0D98356162907" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU57</accession>
    <name>A0A0F4IU57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001135">
        <property type="protein sequence ID" value="KJY25008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25008">
        <property type="protein sequence ID" value="KJY25008"/>
        <property type="gene ID" value="VR44_33725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3658"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_gyraseB" evidence="4">
        <location>
            <begin position="233"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="42365" checksum="981EDFA541CCE730" modified="2015-06-24" version="1">MSEDRSTYDASHIQVLDPREAIRRRPGMYVGSADERGLHHQLFELCDWGVNEVLAGRAGRVDVTLAPEGWVRIAVDGPRVAPDGGNADPRTPRLEALLADVDAQPAVWSRHSVDLSRCGSRMGPFVANALSSRLTAEFMHGETRRVHRYERGFAVGPEAPQVSEAVDGAGAAPGTVVTFRPDAEVFGAAEHSFDVLAERFRELAFLNPGLDIHLTDQRSVDRARSERFRSPGGVRDFVAFLAGRRATASVHGKVHGFALEEPRIAGSVEVALSWGSDHGEEVRGFANSSPTPCGGTHVAGFRAGLAAAVAAFARERGLVSPAAPGLDAGQVSGGLTAVVSVKLDRPEFTGATRGGLGNDGVRDRVADAVREHLGAWLAEDPQLAATVTDRVTAALDALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUK7</accession>
    <name>A0A0F4IUK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001033">
        <property type="protein sequence ID" value="KJY25700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951098.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25700">
        <property type="protein sequence ID" value="KJY25700"/>
        <property type="gene ID" value="VR44_31825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3077"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="41714" checksum="A2FA8D8A4EA165FC" modified="2015-06-24" version="1">MAAITGIGVVAPNGIGAEAFWKATQAGDSVLDRVTRQGCEHLPVRVAGEVRGFDPGSLVEERFLVQTDRFSHYALAAADLALEHARLGRADYADDPYAVGVVTAAGSGGGEFGQRELQRLWGRGPRYVGPYQSIAWFYAASTGQISIRRGFKGPCGVVCSDEAGGLDAFAHAVRAIRQGSQAMLVGATEAPLAPYSVVCQVGYEGLSTGDDPERAYRPFTAKACGFVPAEGGAMFTVEDAAEAVRRGAPVRALLAGHCATFTPPGRPEDSEGLAHAVRGALREAGCAPEEVDVVFADALGTPEADAAEAAALREALGAYGSKVPVTAPKTGTGRAYCAAGTLDTAAAVLALEHGVVPPTPNVFDVCHDLDVVTGSARVAPVRTALVLSRGRMGSNAALVLRKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV69</accession>
    <name>A0A0F4IV69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25524">
        <property type="protein sequence ID" value="KJY25524"/>
        <property type="gene ID" value="VR44_32235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29122" checksum="C30840581057ADEF" modified="2015-06-24" version="1" fragment="single">MSTETSTETTGTGTRTASSELLAAGAVLPADTADAGPGAVPLTARTYRHPALGDERVVVRLAAAELGAAEDLAAGFLGLVPDGEPAVVGLGRRQALGFPEWVLVHHPEDGHHALALVPELDRLARQAKTKPKAALDACTEISERLAASLPHFLPVFLEQAARVFLAVENTTYAAQLFGRARAAEARYGLAVDEDRLDAVFLEFALAGALPVKVLTGYGKELAQRVSPAEAFTRFRRLCVRRTAGGLAPSAQATTELRRLARAAGLTGNLPEQEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWI1</accession>
    <name>A0A0F4IWI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000942">
        <property type="protein sequence ID" value="KJY26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26410">
        <property type="protein sequence ID" value="KJY26410"/>
        <property type="gene ID" value="VR44_30115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="6744" checksum="519F75A2BD7EAB1A" modified="2015-06-24" version="1" fragment="single">MTSGSSSNESGAAVPGRARTGGPAGPGPAGRVALVTGGGSGIGRACALALADAGAFVHVVDVDAEAAGAVAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWQ7</accession>
    <name>A0A0F4IWQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000940">
        <property type="protein sequence ID" value="KJY26437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26437">
        <property type="protein sequence ID" value="KJY26437"/>
        <property type="gene ID" value="VR44_30075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16464" checksum="3D193B0BA766E81E" modified="2015-06-24" version="1" fragment="single">MRGEEDVVVEAVGPAEPAAAVPDADDPAALLLAALGPTGRLWSRGPGHPGFLEVGLGAGSRVALRESGALGVAGPRARLMGVARSVVAQLAALHAPAQLEIVLLAADRVRTLQERRRDWAWLGWLPHVRPAHGQDCRLLLAYDRDQAAARAAELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWT2</accession>
    <name>A0A0F4IWT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000984">
        <property type="protein sequence ID" value="KJY26094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26094">
        <property type="protein sequence ID" value="KJY26094"/>
        <property type="gene ID" value="VR44_30890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21207" checksum="818E0A063079E1A4" modified="2015-06-24" version="1">MRAGTVLDWSDQTEAAGPPQAPTYIWLDCAQWTPRAVRAASCRASSRSRRFFWLTIHTLVCSVPSGELLDVRPSGGPPFGAVKVLAEPAGPVDVGQPVPDRLVQRGSVPRRREGAVLLVVRAGGGLCRLVEHHGHPLGEEGDLLDDPFAGLAVEVLPGQLGRKALVMFQVASWFAPVSSVREIVQFFFSTAFWLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXJ9</accession>
    <name>A0A0F4IXJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">VR44_30725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000974">
        <property type="protein sequence ID" value="KJY26178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950893.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000974.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5075"/>
    <dbReference type="EnsemblBacteria" id="KJY26178">
        <property type="protein sequence ID" value="KJY26178"/>
        <property type="gene ID" value="VR44_30725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2601"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="315" mass="35559" checksum="B9E9989417CAD5A1" modified="2015-06-24" version="1">MSAVAPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYTKMQNLVKGEGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPEALDRDEPRRVGESVVTMDLNYATITGVARDDLADGGAWLYAETVRQIHQQTAGREGGHTKVELLAPDFNAVPELLEEVFASRPEVFAHNVETVPRIFKRIRPGFRYERSLDVIRQARAYGLVTKSNLILGMGEEREEVSEALKELHEAGCELITITQYLRPSPRHHPVERWVKPAEFVELAKEAEEIGFSGVMSGPLVRSSYRAGRLYAQAMEKRAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXP5</accession>
    <name>A0A0F4IXP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26787">
        <property type="protein sequence ID" value="KJY26787"/>
        <property type="gene ID" value="VR44_29245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2195"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="29" mass="3507" checksum="13AEA62A36BABA84" modified="2015-06-24" version="1" fragment="single">MPLGYKDSDRLRKFISDRGKIRSRRVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZC0</accession>
    <name>A0A0F4IZC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000899">
        <property type="protein sequence ID" value="KJY26833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950599.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000899.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26833">
        <property type="protein sequence ID" value="KJY26833"/>
        <property type="gene ID" value="VR44_29110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2157"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="13570" checksum="95F2EC8D60551C42" modified="2015-06-24" version="1">MLILRNTSGELEQPIRTDRGDSEAGRAMIERARALVGHRVRVYRLNERMASNAKLEVRIVVHLADYGLDTDPIHENSAKQNVLAAAEGDTAVAQHAWAEAGLPESGSVTVRQLADALARLPHANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZN6</accession>
    <name>A0A0F4IZN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000885">
        <property type="protein sequence ID" value="KJY26928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950552.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000885.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26928">
        <property type="protein sequence ID" value="KJY26928"/>
        <property type="gene ID" value="VR44_28855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2111"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="28875" checksum="7AEC0793DAFE6C8E" modified="2015-06-24" version="1">MSAEHDTGSGASAWFADQTFWDDFYPHLFSAERAAEAERIVERSPLFRFPSGARVLDLCCGPGLFTVPLARAGHAVTGVDLSAPLLDRARTRCREAGVKARFVEADMLGFAEPEAFDAVVNMFTSFGYLHRHEDNVQVLRNAHTSLAPGGTLLVDLVGKEILARRDERVSLSELDGKVLVQRDTILDDWSRLRSDWYSIEGSRAATGSMTLHLYSAAELRDMLRSAGFTGVRFHGDYEGGPYDHRAERLIAVATKGVDARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0C9</accession>
    <name>A0A0F4J0C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_26945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000804">
        <property type="protein sequence ID" value="KJY27725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950206.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27725">
        <property type="protein sequence ID" value="KJY27725"/>
        <property type="gene ID" value="VR44_26945"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="9">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="8">
        <location>
            <begin position="151"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="45352" checksum="AE3CE12087F88456" modified="2015-06-24" version="1" fragment="single">MSEAASARSRLTADRAAGIGPLEPMLREWLPAQRWFAGKGRGIGRVRPVSTAELLPPGSVPGMLHLLLDVDGDCYQLLLGIRPSPLPPALAPALIGHPRSGPYAGMAVYAALGDPRLAALLLERLRNPGTLGPLRFDRDPDTPIEAGLTARPLSGEQTNSSLIYGDSYILKVFRRVGPGINPDLELPRALAAAGCARVPAPVAWYEAAPGGGEPLTLGVLQPYLRGSDDGWQLALRRLGSGADFTSEAHALGRATAEVHSALADALPTLALGPEQTARLAAGMTARLAATAREVPALRPFEAGLRGAFDALAASRGAGVPAQRIHGDLHLGQTLRTADGSWALIDFEGEPARPLADRRRPEPAVRDIAGILRSFDYAARSHRPFAPAWAESCRAAFCEGYARTTGRDPREDPVLLRAYETDKAVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0D3</accession>
    <name>A0A0F4J0D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000845">
        <property type="protein sequence ID" value="KJY27354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950366.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000845.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000054_gene428"/>
    <dbReference type="EnsemblBacteria" id="KJY27354">
        <property type="protein sequence ID" value="KJY27354"/>
        <property type="gene ID" value="VR44_27805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1799"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14114" checksum="EC2458DB9C845F53" modified="2015-06-24" version="1" fragment="single">MPGYDTSAAPAAREASPVKILIAGGFGVGKTTLVEAVSEIEPLRTEERLTSAGIGVDDLDGIESKTLTTVAMDFGRITLADAGVVLYLFGTPGQERFWFMWDDLLSGALGALVLVDTRRLDRGFPAIDFFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0N4</accession>
    <name>A0A0F4J0N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000792">
        <property type="protein sequence ID" value="KJY27842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950144.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000792.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27842">
        <property type="protein sequence ID" value="KJY27842"/>
        <property type="gene ID" value="VR44_26615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1448"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24351" checksum="2A23A9C2A508CF60" modified="2015-06-24" version="1">MTFLTIGHRGVMGVEPENTLRSFIRAERCGMDVIALDVRLSKDGALVVLHDAEVDRTTDGAGAVADLTLAELRELDAGRGERVPVLEEVLDAVRIPLQVSVRDQAAAGALVELLLRGDLTDRVEVASEDAELLAEVARRVPGVRTALRVERPGADPGELVAPARAAGASAVAVDVRRLSLEAVEAAHAAGLRVTGWAVNSLDLLRLARSLQLDGAATDFPEVRSTGRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0R9</accession>
    <name>A0A0F4J0R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ligand-binding protein SH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_27470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950302.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000831.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27464">
        <property type="protein sequence ID" value="KJY27464"/>
        <property type="gene ID" value="VR44_27470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1662"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="10718" checksum="A89810DEF043C311" modified="2015-06-24" version="1">MPYVLLALAIASEVAGTTAMKYSEGFTRLWPSLGTLLGYAIAFTLLAQTLKSMSVGTAYAIWAGVGTAAIAAIGMLFMGEAATAAKIAGIALVIGGVVLLNLGGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Z2</accession>
    <name>A0A0F4J0Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000782">
        <property type="protein sequence ID" value="KJY27940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27940">
        <property type="protein sequence ID" value="KJY27940"/>
        <property type="gene ID" value="VR44_26405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1465"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7883" checksum="EEDE4A26E5964E36" modified="2015-06-24" version="1" fragment="single">MPHAYQPPQRRSRLTRRGRLLLLFTALLGLGLGATVLLPLLSPGEAPEKPRQLLIPEGWRAAQVYAAIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1T1</accession>
    <name>A0A0F4J1T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950154.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000793.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4837"/>
    <dbReference type="EnsemblBacteria" id="KJY27829">
        <property type="protein sequence ID" value="KJY27829"/>
        <property type="gene ID" value="VR44_26665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1492"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23985" checksum="26735140ABB9D1E7" modified="2015-06-24" version="1">MRENGKIKVFLLDDHEVVRRGVHELLSVEEDIEIVGEAGTAADALVRIPATRPDVAVLDVRLPDGSGVEVCREVRSQDEDIKCLMLTSFADDEALFDAIMAGASGYVLKAIRGNELLSAVRDVAAGKSLLDPVATARVLERLRDGKNGKGDDRLANLTEQERKILDLIGEGLTNRVIGERLHLAEKTIKNYVSSLLSKLGMERRSQAAAYVARLQAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3A2</accession>
    <name>A0A0F4J3A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000699">
        <property type="protein sequence ID" value="KJY28832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949737.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000699.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28832">
        <property type="protein sequence ID" value="KJY28832"/>
        <property type="gene ID" value="VR44_24410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.870"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="11270" checksum="EA39C6833F0C531F" modified="2015-06-24" version="1">MSASTPSEEPVIASITGFQWSSEESVAYEAAIEAINGAVGAYTARIHAERSKAAPDGELVGLWRERRGELAKVREQLDPADHEQIAEVRRRYAALTRQLMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3G9</accession>
    <name>A0A0F4J3G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000749">
        <property type="protein sequence ID" value="KJY28243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28243">
        <property type="protein sequence ID" value="KJY28243"/>
        <property type="gene ID" value="VR44_25820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="1">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23537" checksum="14C5888E984C2DB5" modified="2015-06-24" version="1" fragment="single">MDETDRTLEQLLAGLMAVRDGNLDTRLPEDAGGLPGNIAAVFNGMVAQLSLVTTEVTRVAQEVGGEGRLGGQARVPPVGGVWRELTDAVNSMADNLTSQVRNISQVATAVARGDLTQKIRVDARGEILELKETINTMVERLSSFAEEVTRVAREVGTEGNLGGQATVHGVSGTWMDLTNNVNSMADNLTNQVRNIAQVTTAVAEGDLTRKIDVDARGEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3R1</accession>
    <name>A0A0F4J3R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">VR44_24025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000687">
        <property type="protein sequence ID" value="KJY28972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949659.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000687.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5547"/>
    <dbReference type="EnsemblBacteria" id="KJY28972">
        <property type="protein sequence ID" value="KJY28972"/>
        <property type="gene ID" value="VR44_24025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.797"/>
    <dbReference type="eggNOG" id="COG1274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="248"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="392"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="520"/>
            <end position="523"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="611" mass="67110" checksum="B31B9FDF35206AAD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3S6</accession>
    <name>A0A0F4J3S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28915">
        <property type="protein sequence ID" value="KJY28915"/>
        <property type="gene ID" value="VR44_24170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.786"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="31075" checksum="2C444F6F58B82A72" modified="2015-06-24" version="1">MPTAIAVTSADLVLPAPDRHTPGAAVLRPPGEAGLEAALAETTALLERHGHLVALVPPWLPPATVRRLHTVRAILETDRIALLDIDLPPLGTAVLARQLRQLTVSDFSPGVLASAARLLSHYIYAGALLGSVAKLDRIPVGLKAHARSWSPSAQFAVLAHPQPHLARLGAAAAPAHGGVLPPGPAFATHLTFARGQLSSDWVTAELAPAWKVQGVMENPLPADSARWWATPKLVEFAAAIPDVSVLYQLVASVRREQCRWCGFELIGDRCGFCAAPLAAPPPEDGAAPRARAATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5N1</accession>
    <name>A0A0F4J5N1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000751">
        <property type="protein sequence ID" value="KJY28231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28231">
        <property type="protein sequence ID" value="KJY28231"/>
        <property type="gene ID" value="VR44_25875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="12749" checksum="2D24886242768608" modified="2015-06-24" version="1" fragment="single">MNEDIQVDDLINSAAQAAGGWLGSLPVALMATSATGTIVRWNQVAQELLGYAPPQMLGHHIADLLHPGSDRSLGRSLWETAATGRGVMGTVTAWHRDGHPMELEIWASPVADRQGAGAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5N9</accession>
    <name>A0A0F4J5N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000637">
        <property type="protein sequence ID" value="KJY29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949426.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000637.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29505">
        <property type="protein sequence ID" value="KJY29505"/>
        <property type="gene ID" value="VR44_22730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.478"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6537" checksum="B836B83D64DA2769" modified="2015-06-24" version="1">MGKMKGKAEQLKGKTKEEIGDMADDKSMEMKGKAEKAAGRAKESQADAAARMKKIHDANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5R4</accession>
    <name>A0A0F4J5R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949340.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene479"/>
    <dbReference type="EnsemblBacteria" id="KJY29702">
        <property type="protein sequence ID" value="KJY29702"/>
        <property type="gene ID" value="VR44_22280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.342"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="392" mass="42259" checksum="D2205850E1327410" modified="2015-06-24" version="1">MTAADLLAQARELLTEHPVVDGHNDLPWALRQQVRYDLGRRDIAGDQSAHLHTDIPRLRAGGVGAQFWSVYVRSDFAGDEAVSATLEQIDAVEQLIARYPRDLVRALTADDMEAARADGRIASLMGAEGGHSINNSLATLRALHQLGVRYMTLTHNDTIDWADSATDAPRHGGLADFGREVVREMNRIGMLVDLSHVAESTMRDAIAVSAAPVIFSHSSARAVCDHPRNVPDEVLAQLPANGGVAMATFVPKFILPAAVEWTLAADENLRAHGFHHLDTTPEAMALHRAFEAGRPRPVATAATVADHLDHMREVAGVDHIGIGGDFDGTAFTPAGLDDVSGYPNLIAELLHRGWSRADLAKLTWSNAVRALRDAEAVARDLQATRGPSNAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5T5</accession>
    <name>A0A0F4J5T5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949963.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28286">
        <property type="protein sequence ID" value="KJY28286"/>
        <property type="gene ID" value="VR44_25655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1230"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="34580" checksum="7E9BF565B6045E9E" modified="2015-06-24" version="1">MSGTPYEGADPGLYGPGSVTWHCHGDPVMWIAGVRALYLQALHPRAVRGVMENSAFAEDAWGRLLRTADFVGTLTYGTTGAAERAGAHVRALHRRLSATDPDTGERFRVDDPELLLWVHCAQIDSFLHILRGSGVPLTPAQADRYVDENRVNARLVGLDPAVAPADTAQLAAYFETVRPRLAAGADARAVDAFLRSPPVPPLLVPGRNLLWRPLAGLAYGSLPGWAHRLYGRPAPPARTVTRRLRLTGRVLRTIPAGLRWQLPPGHILRAMRRLGPGSRPSAYTLRKSAAILDRLGRARYDDGHDDGGGFKTWRSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J666</accession>
    <name>A0A0F4J666_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949255.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29852">
        <property type="protein sequence ID" value="KJY29852"/>
        <property type="gene ID" value="VR44_21815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.242"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="DUF5519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="DUF5519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16270" checksum="6BEA25EACA6160BF" modified="2015-06-24" version="1">MLTLTPRQGPAPRVFGPAPHGQGSQISPIMLQEELWGRMRALPYVYMAPTLVSVPHARSLFIPEGIGTGPAEAFQRGREWAHIHPHHDGSLHLTLPKEAEEDVIAAGWGVHHPVQAVVLVYGPRTAEELETVWEIIQFSYRYAVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6J0</accession>
    <name>A0A0F4J6J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000722">
        <property type="protein sequence ID" value="KJY28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949867.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000722.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28531">
        <property type="protein sequence ID" value="KJY28531"/>
        <property type="gene ID" value="VR44_25145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1121"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13395" checksum="A7158338051BDCBF" modified="2015-06-24" version="1">MKIGEASRVSGVSARSLRHYEDEGLIVPGRFSNGFRDYCQSTIDRVLVIRSLLQSGLPVRLIREVLPSLTDGTDAGTEVVCAEFLHEVQGYRDRLAARIAVLSDQQAALDAYLREARCTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L0</accession>
    <name>A0A0F4J6L0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949452.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29454">
        <property type="protein sequence ID" value="KJY29454"/>
        <property type="gene ID" value="VR44_22875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.509"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="14762" checksum="8FA75E054F854616" modified="2015-06-24" version="1">MSESGTLRPLRRHCRCEGGGAPARARREVRSLAEEAGADGRPVPTAVREAALLVASELVTNAVKYAPGPCGLDVVWSAGGLDIDVTDSNPAPPRGRRADPTGATGGYGWPLVRWLCSRVDVRPTPEGGKTVHAHIPVPPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6T9</accession>
    <name>A0A0F4J6T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28646">
        <property type="protein sequence ID" value="KJY28646"/>
        <property type="gene ID" value="VR44_24950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.990"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14563" checksum="963DDF71048B2435" modified="2015-06-24" version="1">MAVSGGAAPVGIDELLERVRATYTRVDARSAYEEWRGGDALLVDIRYQALRERDGVIPGAVVVERNELEWRLDPLGSHRLPEAVSHDVRVVVICNEGYASSLAAASLHALGLRRATDLTGGYQAWRSAGLPTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J767</accession>
    <name>A0A0F4J767_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949363.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29654">
        <property type="protein sequence ID" value="KJY29654"/>
        <property type="gene ID" value="VR44_22410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.371"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10741" checksum="6DC05F746F0E5DAA" modified="2015-06-24" version="1">MQRYTPEGGMTSLIVQHGTYGCPGRFEPAGPWTYLPISETAKITATAPILPSEVMGRPISTHELTGWLDTHPDKGLPFRYHLNAEGVIDTLDEIYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7B3</accession>
    <name>A0A0F4J7B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_22260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949337.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000623.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29699">
        <property type="protein sequence ID" value="KJY29699"/>
        <property type="gene ID" value="VR44_22260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.338"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19710" checksum="0476C5E52FE09B8B" modified="2015-06-24" version="1">MSTPNAVPLSERFRGIAREVVKFGAVGGAGVLVNFGVFNLLRSTTDLQTVRANVIAIVVAIITNYVGFRYFTYRDRDLGSRRREMILFVLFSVIGMVIESGVLYVATYGFGLDSSLQNNIFKFFGMAVATVFRFWSYRTWVFKALPTDAAPSLVVEQRDGHEAVPVAAARTPEPAGNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9B9</accession>
    <name>A0A0F4J9B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948773.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30942">
        <property type="protein sequence ID" value="KJY30942"/>
        <property type="gene ID" value="VR44_19210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8448"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20758" checksum="236DB8C455E87D4B" modified="2015-06-24" version="1">MGTVTLGVSIAVPEPYGSQLQQLRAGFGDAAAHGIPTHVTLVPPTEVEAGRLAAIRAHLAEVARSFPSFAMRLEGTGTFRPLSPVVFVRLAEGVEGCTSLQGRIRDPEGPISRELAFPYHPHVTVAHGISEEAMDRAFTELADYAAGWQCQGFALYEQGSDGVWRKLREYPFGTAATAVPAQSGPASADTAIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9T6</accession>
    <name>A0A0F4J9T6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29741">
        <property type="protein sequence ID" value="KJY29741"/>
        <property type="gene ID" value="VR44_22160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.316"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="472" mass="49274" checksum="28AAFD3AE6BF8FE0" modified="2015-06-24" version="1">MIGAGMGAMATAARLAVAGHQVTVYERGSTYGGALGRYERDGFAFDTGPGLLHLPAVYRDLFVKTGKRPLEDLVEMVQVDPAVRHVLDHATVTLPGTSRGGVAAALDETFGAGAGERWNDLLGRARDAWDAIRRPLLEEPLRPDWQVLGRDPYPALRGSGLLRRRQPTLAEVARRELGGGLGELLRGRVLAYGLDPDSAPAAAAALPYMEQTFGTWYVRGGMRELATAVYERCLERKVEFVFGAPVRAVLSRDGRAAGVRLEDGTEAAADSVVCGIDPRQLPAGSVSWPRGSVQARGGSVPGRLTLLLALRGGRPADAVHRTLVHSPGSAAVQLVTVLRPDDPSTRPDADHEAVTVSAVCGPAGGAAVPDPEKLLDLAARAVPDLRKRLLWQEVRTPGHVEAATGALGGSVPAPALPGDGGRLLYPANATGLPGLYLAGGWAHPGGGLAHAGMTGALVAGLIVEGADFRGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9W0</accession>
    <name>A0A0F4J9W0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000553">
        <property type="protein sequence ID" value="KJY30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948925.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000553.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30589">
        <property type="protein sequence ID" value="KJY30589"/>
        <property type="gene ID" value="VR44_20040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8630"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8540" checksum="74215F849C2A7579" modified="2015-06-24" version="1">MAESTTARTLADRGRPELDLSGADWQPSSRGAGDLQVAFVEGFIAMRDSDRPGDPSLVFAPNGWRKFVLGARAGRFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA86</accession>
    <name>A0A0F4JA86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948855.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000544.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30714">
        <property type="protein sequence ID" value="KJY30714"/>
        <property type="gene ID" value="VR44_19655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="14226" checksum="64CFE866846A2128" modified="2015-06-24" version="1">MSQDLNAELSRIYERCIEQVRAIAALDPTKPVEGWDQYTCTAAKEFASDVEMAWIGAHPEHEVRDTYWAIMGGVPIEHEDVLADSPTRYITYGLTSFARVLQCIEAMRVGRFDPHVPGGIIRNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAF3</accession>
    <name>A0A0F4JAF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000542">
        <property type="protein sequence ID" value="KJY30733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948841.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000542.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30733">
        <property type="protein sequence ID" value="KJY30733"/>
        <property type="gene ID" value="VR44_19580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8527"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="14346" checksum="9BE118223FC3D09A" modified="2015-06-24" version="1">MAPEEVAEYALSLPEVTEHDPSRAMQLYKTGGKIFAVLTPATATRPDEGAPKCDPGLALRLREQYRAVRPGRYGSSHLWNTVILDGTVPDEELTDMIDHSWHRTVDQLPNAHRDRLRALRPGRTAGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAL6</accession>
    <name>A0A0F4JAL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ECF subfamily protein RNA polymerase sigma-24 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000532">
        <property type="protein sequence ID" value="KJY30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30849">
        <property type="protein sequence ID" value="KJY30849"/>
        <property type="gene ID" value="VR44_19390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="20446" checksum="47E6F00FE4FE4E8E" modified="2015-06-24" version="1">MSQWDPTARLSYWAFHSNRRPAYMRFAYLQLGSDTDAEDAVDATFDSIMHEWLRMLHMDRLDAYAWTVLKQRIVDWQQRRDPRLRRPEPMDISAFEAALKEAHPDQYEVLTDTIRFYQAVSRLAEGQRDTVMLRYGLQCTPGEAAAVMGVDEATVRSQLGQAHRRLARLLDAVPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB33</accession>
    <name>A0A0F4JB33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000524">
        <property type="protein sequence ID" value="KJY31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31004">
        <property type="protein sequence ID" value="KJY31004"/>
        <property type="gene ID" value="VR44_19115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8427"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PG_binding_1" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="94"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22835" checksum="7E57FC7116CBD2EF" modified="2015-06-24" version="1">MANGDENDQVRELQARLRQLKLMSSAPTGFYGSKTTAAVKSFQSQHGLGATGAVDEATWQKIQGLSRKPTEEELRPPTTNEVAAPDPRCMQGRVMCISKESRTLAWMIDGKVVSSMDVRFGSENTPTREGLFQVEWKAKDWTSTIYHTPMPYSMFFSQGQAVHYSADFAARGYAGASHGCVNVRDKAKLSALFDQVKVGDKVVVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBU0</accession>
    <name>A0A0F4JBU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948413.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31832">
        <property type="protein sequence ID" value="KJY31832"/>
        <property type="gene ID" value="VR44_17315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7998"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16476" checksum="4D2869875A6BAC68" modified="2015-06-24" version="1">MSPPPSTAQRGSATRPFTLWKEVATAYLAPALTAGLGGFLSRQPEVTRAAFTSIGVTSALVACIVGSWLHRRGRPRLWTAAMPRPVLTLGLAVTAVAIAGLAGWFVSDWLPSHTPVPDARWLQRLRIDLPLSAGLATTIVTWRWHGTASRQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC66</accession>
    <name>A0A0F4JC66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948571.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31409">
        <property type="protein sequence ID" value="KJY31409"/>
        <property type="gene ID" value="VR44_18160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8179"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470564" evidence="1">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16523" checksum="6B3323A0A6E01429" modified="2015-06-24" version="1">MVAVRRGAVRSVVVAGSLVLAGAGPAGASGAGPEADVAYHGRVSLARGQLRVWMVPQNEGPSGLANATVRVRLSADLADVQESAGGCARAGEREVVCETGPLPEHGRGRHIGLVLGLRERPSEVAVRIDTWWNGGATDRNRGNNEYVVLALDTGDAYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC93</accession>
    <name>A0A0F4JC93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948417.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31835">
        <property type="protein sequence ID" value="KJY31835"/>
        <property type="gene ID" value="VR44_17345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8004"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="22262" checksum="1FC1A4D8F659C711" modified="2015-06-24" version="1">MQEAPETPTRQIRAVHTATTLTVYQAYSPALGLPAARDGRFPPAWKRERMTWIKPSFLWMMYRCGWATKEGQETVLAVEISREGFDGALAEACLSHYAPKVHADRADWKKTLSRSPVRVQWDPERDPHLNPLPYRSLQLGLSGPASRAYADEWTVSIRDVTPLVREIHGLLRAGDTEAARALLPVETPYPSGPLPHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCB5</accession>
    <name>A0A0F4JCB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948593.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31398">
        <property type="protein sequence ID" value="KJY31398"/>
        <property type="gene ID" value="VR44_18255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8198"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="14363" checksum="A19EDBA7FD38EA5E" modified="2015-06-24" version="1">MPDTTRRRTGTALAALLSADGLAHLYWATGATWPAPSERALSLAVLGTEVSFAPPVVLPLAALTLTAGAAVLAHSRHRGGRAARAVTGAVAAGLAVRGLAGLGWAAGLLPSPPGSPFHALNLAVYTPACLGFGWAAARLARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCK8</accession>
    <name>A0A0F4JCK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000484">
        <property type="protein sequence ID" value="KJY31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31544">
        <property type="protein sequence ID" value="KJY31544"/>
        <property type="gene ID" value="VR44_17900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470325" evidence="2">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="7078" checksum="CDE12D1E034F915F" modified="2015-06-24" version="1" fragment="single">MQYTAGVRRTAAALAAAAAATALMTACGPTGDSGAPAQPTTPPAASGPAQATPAGSGTGGTGATGGTGGSGGSAGSGGSGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM9</accession>
    <name>A0A0F4JCM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948272.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32112">
        <property type="protein sequence ID" value="KJY32112"/>
        <property type="gene ID" value="VR44_16550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7742"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12847" checksum="686F5E75F9B83D9F" modified="2015-06-24" version="1">MSRVRPGRDDSPDRLYTLTGGRSRSGSDAFDLVTLIVAECDPVPGMQSEHAAILRMCRYPTAVVEVAAELGLPVSITRILLADLLAAGRVSARHPRAAKYRLPEPELLEQVLVGLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCN4</accession>
    <name>A0A0F4JCN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32117">
        <property type="protein sequence ID" value="KJY32117"/>
        <property type="gene ID" value="VR44_16590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7750"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15242" checksum="42D57746D9808166" modified="2015-06-24" version="1">MPAAVGDAIARHDWASTTCGCGRSADHLEDTLWHAAEGHPAAFHALEGHVFTRPRLWPPAPAVCAVLMAVWAAGPPRLATREALLRTLLALLTSEDDGTAYEAGLYGQCAAHVRAGLPQLTGPLAGRPGSASAAYADGIRDIIGLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEN0</accession>
    <name>A0A0F4JEN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948080.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32655">
        <property type="protein sequence ID" value="KJY32655"/>
        <property type="gene ID" value="VR44_15565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7513"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470464" evidence="1">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="25002" checksum="7BD1A76E48ECDAF0" modified="2015-06-24" version="1">MRHISPAATLFAVAVLPLALTACSATPKAAPKAAPTSAATAAPAAPKAADAAPAVDGPNKGLLTGTQLKAALAPASFFASGYTADPADARDTGAAYRAPATAEVPTPDCTKLGGTAWTEITGITGVSFAQNAYVNKNTSEEYAQEIDVYQGTTATTVLGALGMLSKACPTYSDEPTHSTVTVTEKPLADVGDGAWAITETSPAWQGGTTLVAARVGHSVVTVLVSSSTDKGLAGATKLTNQLVSNLKGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEZ3</accession>
    <name>A0A0F4JEZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_17925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000485">
        <property type="protein sequence ID" value="KJY31531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948527.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000485.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5660"/>
    <dbReference type="EnsemblBacteria" id="KJY31531">
        <property type="protein sequence ID" value="KJY31531"/>
        <property type="gene ID" value="VR44_17925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8129"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="35216" checksum="657EDF917F044D17" modified="2015-06-24" version="1">MLLEVRDLHVEFTTRDGVAKAVNGVNYSVDEGETLAVLGESGSGKSVTAQAVMGILDTPPGRIAGGRILFKGKDLLKMKEDERRRIRGAEMAMIFQDALSSLNPVLSVGAQLGEMFEIHRGMSRKDSRAKAVELMDRVKIPAARQRVADYPHQFSGGMRQRIMIAMALALEPSLIIADEPTTALDVTVQAQVMDLLAELQRELGMGLILITHDLGVVADVADRIAVMYAGRIVESAPVHAIYRAPAHPYTRGLLDSIPRLDQKGQELYAIKGLPPNLLAIPPGCAFNPRCPMARPVCRTEVPPLAEVAPDRASACFFWKECLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFK6</accession>
    <name>A0A0F4JFK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948121.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32538">
        <property type="protein sequence ID" value="KJY32538"/>
        <property type="gene ID" value="VR44_15775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7561"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22630" checksum="56F7D467FFE3F7DD" modified="2015-06-24" version="1">MGVDITVLVVDWVHLSEIAPDERLRVVQESAYADDDPDGDGDVVDGWVWPTGAERSWLGRYEFRGTLGSYKPHFRAADGWEKVRGAAGGEVRAALDEFLEGLIWWGPRPDVDAEQVDAGVFPSLDGLWRQGPLIVRGPETVARLRRSWQAAAPGLEGLRIPYGELAGREPGQWIAGFDEFAELLGGWAEVLGEADRRGWGVIGLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG56</accession>
    <name>A0A0F4JG56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosylmethionine synthetase</fullName>
            <ecNumber evidence="3">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000363">
        <property type="protein sequence ID" value="KJY33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33337">
        <property type="protein sequence ID" value="KJY33337"/>
        <property type="gene ID" value="VR44_14120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7145"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8536" checksum="65D9105CFCFB25C2" modified="2015-06-24" version="1" fragment="single">IAHRLSRRLSEVRKNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSTQHAADIDLDSLLAPDIREFVVEHVLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGI1</accession>
    <name>A0A0F4JGI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948005.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000387.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32873">
        <property type="protein sequence ID" value="KJY32873"/>
        <property type="gene ID" value="VR44_15140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7446"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="35098" checksum="22A3BFAF0AE75962" modified="2015-06-24" version="1">MTVEVVAVLALDGVAPFELATPGQVFGTANEAAGTVHYEIRVCAPGRSATTAAQHGAFRIDTPYGLEGLVGAHTVVIPAHAGFLTPPPSDVTDALARAAAQGARLASVCVGAFTLAATGLLDGYRATTHWQYAEEFARRHPRVEVDPAVLFVDHGRLITSAGVAAGLDLCLHLVRRDLGAALAAATARRIVMPLQRDGGQAQYIERPAAPADPSALQPVMQWMESRLDRPLTLADIAGHARISVRTLNRWFREQTGTTPLQWLLHARIHRARQLLETTDLPITLLADRTGFGSPTTLRHHFTRHTGTSPYAYRAAFRQREPLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGJ0</accession>
    <name>A0A0F4JGJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_16700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000441">
        <property type="protein sequence ID" value="KJY32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32081">
        <property type="protein sequence ID" value="KJY32081"/>
        <property type="gene ID" value="VR44_16700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7773"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="484" mass="51678" checksum="D69D83DCF8DBEE5B" modified="2015-06-24" version="1" fragment="single">SAGSRSKGGSGAGKAPRTLGPQGEFAMPRTATPALPPVESFGELGLPAELVETLAAQQVRDPFPIQAATLPNSLAGRDILGRGRTGSGKTLAFGLALLARTAGRQADPKRPLALVLVPTRELAQQVTEALAPYAQALRLRMATVVGGLSIGRQSGALRTGAEVVVATPGRLSDLVKRRDVHLERVRITVLDEADQMCDMGFMPQVTEILDQVHHDGQRMLFSATLDRNVDQLVRRYLKDPVSHSVDPQSASVGTMDHHVLHIHAADKVSAATEIAAREGRVIMFLDTKHGVDQFVKHLRAMGVRAEGLHSGKSQPQRTKTLGQFKDGQLTVLVATNVAARGIHIDDLDLVVNVDPPADSKDYLHRGGRTARAGESGKVVTLVTPNQRRDMVRLMADAKIRPTITQVRSGEAALSRITGARKPSGVPLSGALPTDAKGRPSGTELGFRGLGTRPGRTGRGKESRKTIEARQAAEARRAARVRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ45</accession>
    <name>A0A0F4JJ45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_13135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000334">
        <property type="protein sequence ID" value="KJY33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947645.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2345"/>
    <dbReference type="EnsemblBacteria" id="KJY33834">
        <property type="protein sequence ID" value="KJY33834"/>
        <property type="gene ID" value="VR44_13135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6690"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="59"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="34467" checksum="CD88D528D10F85F9" modified="2015-06-24" version="1">MSDTTPDGALATSKPPSDDAGLTPAQLAAKYGLSVSGARPTLGGYVRQLWERRHFIMAFSRAKLVAQYSEAKLGQIWQVATPLLNALVYYLIFGLIMNAGRGMEKGVYIPFLVTGIFVFTFTQSSLMAGVRAIPGNLGLVRALHFPRASLPISFSMQQLQQLLYSMIVVLIVTVSFGNYPRASWLLVIPTLALQFVFNTGLALIFGRMGSKTPDLAQLMPFITRTWMYASGVMFSISGALKDRHVPEWVTDVLQWNPAAIYMDLVRYALIDDYGRHNLPPHVWAFAVGWAVVIGLGGFVYFWKAEERYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJK2</accession>
    <name>A0A0F4JJK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000325">
        <property type="protein sequence ID" value="KJY33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33938">
        <property type="protein sequence ID" value="KJY33938"/>
        <property type="gene ID" value="VR44_12930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6703"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470624" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="6855" checksum="E5B90A265CE3BC18" modified="2015-06-24" version="1" fragment="single">MCAAALLAAVTAAPARADTGAPDLSASGPRGAVWALKDTGPAAANGVRFRGLAAVGHATAWVAGTKGTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJS8</accession>
    <name>A0A0F4JJS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000316">
        <property type="protein sequence ID" value="KJY34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34069">
        <property type="protein sequence ID" value="KJY34069"/>
        <property type="gene ID" value="VR44_12680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6615"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470583" evidence="1">
        <location>
            <begin position="25"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="23318" checksum="559B21913FB0DE11" modified="2015-06-24" version="1">MAAVTCAVLLTATASACLPELAGAGAGPSPSAAAPDPFAGRDPAAVLRAAYEETERAATRTAVVSRRIGEREITAQLTFEGDGGCWGEVRVERSGTGEILVDDAKVSLRGDAGFLQDQFRNQPFKSPDTADGWIDMKPGDPAVSHLVALCADGSPARTFPAERTGLRREPDTRLNGRPVAVLVSKGPGGVEITDHVSLDGRPYLVRHAETGPEGRNVTYGSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJZ6</accession>
    <name>A0A0F4JJZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000365">
        <property type="protein sequence ID" value="KJY33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947836.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000365.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3365"/>
    <dbReference type="EnsemblBacteria" id="KJY33296">
        <property type="protein sequence ID" value="KJY33296"/>
        <property type="gene ID" value="VR44_14175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7181"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20995" checksum="CA21CD4F7057CC52" modified="2015-06-24" version="1">MTPAVIQLAAEAAERQSAEVTDWGARIAWVIGLLVFIAFVYWLMRQGWKWRGALQSDLPELPAAPDGLPEHRLALTGRYHGSTTAGQWLDRIVAHGLGVRSRVELTLTDAGLHVVRPGATDFFVPAPRLRGARLDKGIAGKVLTEGGLLVVTWAHGDKLIDSGFRSDRAAEHAAWVEAINSMNQSITTEGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK63</accession>
    <name>A0A0F4JK63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">VR44_14105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007264038.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2580"/>
    <dbReference type="EnsemblBacteria" id="KJY33361">
        <property type="protein sequence ID" value="KJY33361"/>
        <property type="gene ID" value="VR44_14105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7135"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="8758" checksum="CF21D8F6791E4E07" modified="2015-06-24" version="1">MAHKKGASSTRNGRDSNAQRLGVKRFGGQVVSAGEILVRQRGTHFHPGAGVGRGGDDTLFALLPGAVQFGTHRGRKVVNIVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKA0</accession>
    <name>A0A0F4JKA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA family drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_11360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000263">
        <property type="protein sequence ID" value="KJY34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947313.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000263.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34762">
        <property type="protein sequence ID" value="KJY34762"/>
        <property type="gene ID" value="VR44_11360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6167"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022754999" evidence="6">
        <location>
            <begin position="29"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="407" mass="40345" checksum="AB3DE417CA85A575" modified="2015-06-24" version="1" fragment="single">RVLLTGLAAFAAASAVAALATSPGVLIAARAVQGAGAAAVAPASLALAVGLHPPGQARGRALAVWGAVSGAGGAAGVLLGGLLTQAWGWPWIFHTVAIGSCAVLAATAAYVPAAGPAERVGFDWAGTATSALALTALVWALTTARRSGWTDPWVPAAFGAAAVLAVTFWRIECTSAAPLVPPRLFAARDVTVGNLLTGLFGSVWIALFFFLPLYQQQVLGEDPLTTGLGQLPLAVANMLGATLAPTLARRVGARTALVAALLTEAAGMLWLSRIGTDGTFPADVLGPSVLVGLGLGVAFVQLTSLSVAGVAGPDTGLAGGLANTTRQVGGAVGLAVLTTVAGSVTSSAARHQPPLEALAAGYRTAFALGSAVLAATALLAVLLVRRTPAADRPHHAPAPEPASPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLP0</accession>
    <name>A0A0F4JLP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmE2</name>
        <name evidence="5" type="ORF">VR44_10515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947155.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2388"/>
    <dbReference type="EnsemblBacteria" id="KJY35262">
        <property type="protein sequence ID" value="KJY35262"/>
        <property type="gene ID" value="VR44_10515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5846"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="9206" checksum="674643770BE18DB2" modified="2015-06-24" version="1">MKPGIHPAYGPVVFRDKAADFAFLTRSTATSDKPVKWEDGNTYPVIDVEISSQSHPFYTGTARVLDTAGRVERFQRRYGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLQ4</accession>
    <name>A0A0F4JLQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947626.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33891">
        <property type="protein sequence ID" value="KJY33891"/>
        <property type="gene ID" value="VR44_13030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6724"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="34162" checksum="408CBA4B1D71E6DC" modified="2015-06-24" version="1">MNHTGHIAPGSPETPAGRLDPEPPPPGGVLWTTAGDIRSLLTLPAAFTMQVAHPAVGAGVDQYSVFRTDPWGRGERSLRSVMLWVYGGDEAAAEGRRVRRLHKEIRGTDTRGRRYHSLDPACYAWVHATGFPVAQYAGRYLFRRITPAQERQMYREWLRVGRILGLRDRDMPQTIEEFWPYYHRMLAEEIEPTKVARELVATDADLPRPEPASPALRLLLRLTWPLLRTGYLRFRAFVTVGYMPPDARAAIGLEWTPAQERRLRRFSTAVRLLVPLLPERLRYLPQARAARARWRAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLQ9</accession>
    <name>A0A0F4JLQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_13035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947631.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.032"/>
    <dbReference type="EnsemblBacteria" id="KJY33896">
        <property type="protein sequence ID" value="KJY33896"/>
        <property type="gene ID" value="VR44_13035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6725"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470676" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="24"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="49"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="310"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="499" mass="54502" checksum="0FE55CEEC2D5661F" modified="2015-06-24" version="1">MYRKVIAPSVLAASLLLVIPASAASSVQGAPGIGDSYYPESGNGGYDVSHYDLRLQYQPKTDLLEGTATLLTTAKQDLSRFNLDFGLKVSEIRVNGAKAKFATSGAHELEVTPAQPLAKGKQATVVVKYAGKPSEFKIDGWSAWQRTPDGGIAAQEPDSAVWWFPSNDHPLDKATFDISINVPDGTQAISNGVLQSQTSKLGWTRYNWRSNKPQATYLATLAIGKFDITTDKTASGLPILNAYSKDLGDNAGAARASVERTGEVAEWLESVFGPYPFNALGGYVPNVPTGFALETQTRPFYSPRQFANGANVSVVVHELAHQWYGDSVSVDNWKDIWVNEGFARYSQWLWSEKEGEGTAQELAQWAYDTRPAEDPFWQVKPGDPGAENQFHGAVYDRGAIAIQALRNEVGDEKFFQILKGWPTERAYGNVKVGDFVRYAEKISNKPLAQLFDTWLYTPGKPAFGAPAAKPGARAQAPAKPAVEPKSWKKIAATNNIHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPU3</accession>
    <name>A0A0F4JPU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000192">
        <property type="protein sequence ID" value="KJY35869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946877.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000192.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35869">
        <property type="protein sequence ID" value="KJY35869"/>
        <property type="gene ID" value="VR44_08990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4970"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="34724" checksum="3C6804D2D94DCE06" modified="2015-06-24" version="1">MRSSFLADAPAIREPRHAPVAHVMRGGLIEGVHYGSVVVLDDGGGVRLGIGDIEAACYPRSALKPVQAVAMVRAGLPLDGALLSLAMGSHSGEEHHLAGVRLILELAGLTEADLRNVPDLPYGPAVRDAWVREGRGPSRLAQNCSGKHAAMLYLCKLSGWPLESYLDADHPLQRTIAEAVEDLTGQRVANVTVDGCGAPLFAVSLHGLARAAARIATAAPDTAEHRVAGALRLHPEMASGAGRDSAALMRAVPGLLAKDGFEGVHLAALPDGRAVAVKISDGADRARVAVTAAALARAGVEPRLLAGFAGEPVTGGGRAVGGVRPVAALDPPGAPATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRP5</accession>
    <name>A0A0F4JRP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947027.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35616">
        <property type="protein sequence ID" value="KJY35616"/>
        <property type="gene ID" value="VR44_09795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5459"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="28474" checksum="7725184D626D9F29" modified="2015-06-24" version="1">MRIATFNVNSITARLPRLLAWLEASGTDVLCVQETKCTAEQFPADALRELGYESAVNATGRWNGVAVLSRVGLEDVVVGLPGGPDYEGVQEPRAISATCGGVRVWSVYVPNGREVEHDHYGYKLDWFRALTTAIAADAAGPRPFAVLGDYNVAPTDEDVYDPAVFEGLTHVTPAERAALEALRGAGLSDVVPRPLKYDRPYTYWDYRQLCFPKNRGMRIDLVYGNEPFVKAVKDAYVDREERKGKGASDHAPVVVDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRR9</accession>
    <name>A0A0F4JRR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946687.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3184"/>
    <dbReference type="EnsemblBacteria" id="KJY36443">
        <property type="protein sequence ID" value="KJY36443"/>
        <property type="gene ID" value="VR44_08000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4424"/>
    <dbReference type="eggNOG" id="COG2824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12535" checksum="CD315DF9A167049F" modified="2015-06-24" version="1">MSDSLPPCPKCSSEYTYEMNALVVCPECGHEWVPAESAEGGADATSERVVKDAVGNVLRDGDSVTVVKALKVKGSPSGIKAGTKVRNIRLIDGVDGHDIDCRIEGFGAMQLKSSVVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRU3</accession>
    <name>A0A0F4JRU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000152">
        <property type="protein sequence ID" value="KJY36549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36549">
        <property type="protein sequence ID" value="KJY36549"/>
        <property type="gene ID" value="VR44_07780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="19785" checksum="4D22990188DD65C9" modified="2015-06-24" version="1" fragment="single">GADDPAALAQVAESRRWLASGTVPGGSGARREGAERALLSMRALLRPNGAFAAAWYPFWDFSWPRDSAFAAAAFAHTGHDEEAYRILRYNAGTQRPDGTWEARTRLDGSGPPDDRRWQLDANGWVPWAAWQWYRTAPAAGRAERLRALYPALAKAADFTAGSLDAEGLPPASPDYWELPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRV9</accession>
    <name>A0A0F4JRV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000158">
        <property type="protein sequence ID" value="KJY36488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36488">
        <property type="protein sequence ID" value="KJY36488"/>
        <property type="gene ID" value="VR44_07940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4409"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14828" checksum="0737B185FB87D484" modified="2015-06-24" version="1" fragment="single">MGDPSLALPGGADPAERTRVLRRAHDAFTRDGRVEPPVRAVIAKSWRRCARARVSPECAPRLDRPEPELLAYREHHPLARVMPLFRDLVGAFAAHGAHLLAVCDARGGLLWVEGEPATLRRAEGLGFVPGSRWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS56</accession>
    <name>A0A0F4JS56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946379.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene61"/>
    <dbReference type="EnsemblBacteria" id="KJY37202">
        <property type="protein sequence ID" value="KJY37202"/>
        <property type="gene ID" value="VR44_06330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3020"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="66"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="48310" checksum="BDEEC7A115AA4E2A" modified="2015-06-24" version="1">MSENAYEDPYLIISSDCHAGLPTERYRPYLDSRFHRQFEEFLGQRDARREEATRLGVRNEAFAEKWFHDHEEGLKGGWDTTQRLKELDGDGVAAEVVFPDADAVDSQTAAPFGVGLGLSGDQDPALGMAGAQAHNRWLAEFVSQNPERHCGVALLPVTGEPDKVVAEIHRAKESGLGALMIPSMWVDKAPYHDRRYDPVWAAAAETAMPIVTHSGAAPRHEYGDHLGIYVSEVTWWPSRPLWFLLWSGVFERHPALKFGVAESGCWWLPNQLWFMDRLYLGAHGGKKLSPFAELKRPPSEYLDRQVFICATNTKRRELAQRYEIGVDNILWGSDFPHPEGTWPDTRNWLAKTFHDIPVAETRRMLGLAAAEVFGFDTERLAPIARRIGPTPAELGQSPDQASVEASWARSRETGRHWLTGEDFPVLGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT15</accession>
    <name>A0A0F4JT15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36101">
        <property type="protein sequence ID" value="KJY36101"/>
        <property type="gene ID" value="VR44_08630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20944" checksum="4387154578505080" modified="2015-06-24" version="1" fragment="single">MPQQSPLDVPEGDPFGPHNLPYGVFSTPEEPQRRRVGVRIGGYVLDAGAVAVALGSPYAGLLAQGSLNPLLAAGRTAWRDVRRALTAWVTDPGHRETVEPHLLPLDGVVLHLPYEVADYVDFYASEHHATNVGRIFRPDGDALTPNWKHLPIGYHGRSGTIVVSGTDVVRPSGQRKAPADPAPVFGPSVKLDIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT27</accession>
    <name>A0A0F4JT27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">VR44_08470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946776.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene930"/>
    <dbReference type="EnsemblBacteria" id="KJY36116">
        <property type="protein sequence ID" value="KJY36116"/>
        <property type="gene ID" value="VR44_08470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4757"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20027" checksum="946801A163F42F2F" modified="2015-06-24" version="1">MGLEEKLPSGFLLTTVEQAAGWVRKASVFPATFGLACCAIEMMTTGAGRYDLARFGMEVFRGSPRQADLMIVAGRVSQKMAPVLRQVYDQMPAPKWVISMGVCASSGGMFNNYAIVQGVDHIVPVDIYLPGCPPRPEMLMDAILKLHQKIQGSKLGVNREEAAREAEEAALKALPTIEMKGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU93</accession>
    <name>A0A0F4JU93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_05200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946164.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37740">
        <property type="protein sequence ID" value="KJY37740"/>
        <property type="gene ID" value="VR44_05200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1355"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="474"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="839"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="497"/>
            <end position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="857"/>
            <end position="864"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1350" mass="144382" checksum="4BDD7B8452CF5E25" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUZ8</accession>
    <name>A0A0F4JUZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946176.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7108"/>
    <dbReference type="EnsemblBacteria" id="KJY37664">
        <property type="protein sequence ID" value="KJY37664"/>
        <property type="gene ID" value="VR44_05260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1686"/>
    <dbReference type="eggNOG" id="COG2390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="68"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="35976" checksum="3C7EEECEED5AA39E" modified="2015-06-24" version="1">MSAGRSALRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLETALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPADASEDAPDPENLGAVAADLLGELVNEGDVLGLAWGRSTIHMAASLHRLPPCTVVQLTGVYDAGTAERGSVEAVRRAAQVSGGDAHPIYAPMLLPDPATAAALRNQTGIARAFEYFDKVTVAAVSIGSWEPGISTVHDMLTDEERAHYASLGVAAEMSAHLFDAEGRRVGRDLGERCITVEADRLRRIPEVVAIAGGLRKAAAIGAVLRSGLVTSLVTDTAVADYLLTESAPGLRPALERADPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW62</accession>
    <name>A0A0F4JW62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37221">
        <property type="protein sequence ID" value="KJY37221"/>
        <property type="gene ID" value="VR44_06235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3001"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14038" checksum="26F6782D94258392" modified="2015-06-24" version="1">MIPGALARPDGPAPAPGPEAAALATVDFSEIPAEPPVRPEQPAGRELYGSDCDTEIDGSQVIAYCHNGFPETDLLRLHVECERWWDLDGDSALVPLDPTGRIRLTGRCWKEVRTAWVSHQRPSGPSGPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW64</accession>
    <name>A0A0F4JW64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945810.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38607">
        <property type="protein sequence ID" value="KJY38607"/>
        <property type="gene ID" value="VR44_03185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7852"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23816" checksum="D802967B1B15FC94" modified="2015-06-24" version="1">MSDATLHALGQDPGDFAASIADQIESFIVAVTEVAKGEDPDSAVPFLLLEVSQLLLAGGRLGAYQDVLPEERYEPDLGPEPDVDDLRERFAVMLEPVDVYSEVFDPYEPRKAPVAHRISDDLADVVADLRHGLIHHQAGRITEALWWWQFSYFTNWGPTASATLRALQSLISHVRLNQPLAALDGLDTDEDLTEEDLVEQAGQVMEQELGRLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXM3</accession>
    <name>A0A0F4JXM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946165.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37741">
        <property type="protein sequence ID" value="KJY37741"/>
        <property type="gene ID" value="VR44_05205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1356"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046175">
        <property type="entry name" value="DUF6177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19674">
        <property type="entry name" value="DUF6177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="461" mass="47436" checksum="AA553F5B4E94EF48" modified="2015-06-24" version="1">MTKDVIALTPKMPDTAALLVALAAGGGGLDAAPAGEGAVVQLLGAGGRPLVSVEAPVLVQVPGEAQRLLGTPSATPVWWTETRASTAVPEAAELAGAVAGRLAEVLGGTVWPEGAGRVTTVPVDSEASAAPAPAGALPTVDVVTESTAVVLADRPVVPLTAWLSDVLRTTASFGAALHIVTPAHCRLSLPLRTVLTGAPNRWVVQDPACGYYDGLSGAVLAWQDGTFAPVRDEQGQTRLAEAFRRPATGPGERRLTVHLRTEHPAEADTLLGGALETAWHALTGAGPAGWGTAEPVNLPWSPRQFTDLARSRMPEPTLVTAVGRPERPALATVRVTRTATGVEEDVTLSLGYGPSEEVPLGAVEELAGALVTGHGLVSMLVSVGPGRRDLSLTPRITAPAVPVSFTLGARGVTEATLSQARRPPLALKPVQVGPERRPGLHYPLGDGTDPAAWETLSTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYN4</accession>
    <name>A0A0F4JYN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_04175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945983.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene831"/>
    <dbReference type="EnsemblBacteria" id="KJY38101">
        <property type="protein sequence ID" value="KJY38101"/>
        <property type="gene ID" value="VR44_04175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.124"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="41795" checksum="9320CDAC267BDBDC" modified="2015-06-24" version="1">MPLDHRLTPEHEELRRTVEAFAHDVVAPKIGDLYERHEFPYEIVREMGRMGLFGLPFPEEYGGMGGDYLALGIALEELARVDSSVAITLEAGVSLGAMPIYLFGTEEQKREWLPKLCAGEVLGAFGLTEPGAGSDAGGTRTTAVRDGDEWVINGSKCFITNSGTDITGLVTVTAVTGRKADGRPEISSIIVPSGTPGFTVAAPYSKVGWNSSDTRELSFDEVRVPVANLVGQEGRGYAQFLRILDEGRIAIAALATGLAQGCVDESVKYAKERQAFGKPIGDNQAIQFKLADMEMRAHMARLGWRDAASRLVAGEPFKKEAAIAKLYSSTVAVDNARDATQIHGGYGFMNEYPVARMWRDSKILEIGEGTSEVQRMLIARELGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZF9</accession>
    <name>A0A0F4JZF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945624.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39098">
        <property type="protein sequence ID" value="KJY39098"/>
        <property type="gene ID" value="VR44_02200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471194" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7382" checksum="5AFEF4CDF8AC31F1" modified="2015-06-24" version="1">MLKFRRATGAASIAALAAGLFLFGAAHTTGQGAENRVTVEAGNQNWDIVSPDLDHWATASFTTSYDLKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K055</accession>
    <name>A0A0F4K055_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000007">
        <property type="protein sequence ID" value="KJY39795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945313.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39795">
        <property type="protein sequence ID" value="KJY39795"/>
        <property type="gene ID" value="VR44_00510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.102"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="23425" checksum="438CF283E4210646" modified="2015-06-24" version="1">MLLLAVDTATPAVTVALHDGESVLAQSHQVDARRHGELLLPSVDRVLAEAGVKLEALTGIVVGVGPGPYTGLRVGLVTASTFASVLGIPVHGLCTLDGLAYAAGTAGIEGPFTVATDARRKEVYWARYEDPRTRVGEPAVDRPADIAEQVAGLPAVGQGARLYPEVFTDARDPEHQSAAALAALAAERLAAGGPFENADGVPPAPLYLRRPDAQVPKNYKVVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0A4</accession>
    <name>A0A0F4K0A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000017">
        <property type="protein sequence ID" value="KJY39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39534">
        <property type="protein sequence ID" value="KJY39534"/>
        <property type="gene ID" value="VR44_01380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4707"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="21968" checksum="CF6BDE11AC99A96D" modified="2015-06-24" version="1" fragment="single">PAPRAAPAAAGAGVQRPLRREDAIRNHAQILAAAEQLFTERDPSAVTMDQIAKAAGVGRATLYRRFPDPPAVAAALLDEHERILQGRLAFGPPPLGPGAPPAQRLAAFYAAVLDHLERHLPLTLGIRPGPARFSAGAYRHWRAHVRSLLVEAGAADPDVSVDALLSPLAPEVYQFQRHTLGFPPERIAETLGRLARGVLPEPRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0P6</accession>
    <name>A0A0F4K0P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_00670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945343.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4809"/>
    <dbReference type="EnsemblBacteria" id="KJY39689">
        <property type="protein sequence ID" value="KJY39689"/>
        <property type="gene ID" value="VR44_00670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2840"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="235"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="39670" checksum="D0B8AB28F6B0BC2E" modified="2015-06-24" version="1">MDFTFTEEQQAAVEAAKAVFADVAPDGVPSPALTPGAVAEEFDRPLWATLAGSDLLGLVLAEEHGGAGLDTIALCLVLREAARVLARVPLLEHCATAMAVQAHGSPELTAALLPGAGRGTLVLTVAAQGRTGHDPAELAVTARREGAVWTLDGVQTAVPWAHSSDWIAVPAHTGDGEAVLALLPRTTEGLTLADQYSTSGEKFAELTLDRVRVPAAHVIDAPGAWERLRQVLATGTCALALGLGEAVLTMTSGYTSKREQFGFPVATFQAVAVQAADRYIDLRAMEVTLWQAAWRLDAATGAAGGPLPASGDVAVAKIWASEGVRRVVQTAQHLHGGFGADTDYPLHRYHAWAKQLELQLGPAAAHEEALGDLLAAHPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Q7</accession>
    <name>A0A0F4K0Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945353.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39699">
        <property type="protein sequence ID" value="KJY39699"/>
        <property type="gene ID" value="VR44_00725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2850"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471416" evidence="1">
        <location>
            <begin position="32"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="487" mass="52108" checksum="845741699F895DA1" modified="2015-06-24" version="1">MNKPLRRISLFCGLLVLALLIRTNWLQYVQAEELSTRKENRRVQIAQYATERGNIIVGGQPITGSAVTDGSDFKFKRTYLDGPLWAPVTGYASQAFGSTQLEKIDDGILTGNDDRLFFDRTIGMFTGEKKQGGNVITTLNAAAQKAAFTSLGDKKGAVAAIDPRTGAILALASTPSYDPSTFAGNSKNDEKAWRTLNDSADKNLVNRALRETYPPGSTFKVVTTAAALEHGVVSDINTPTDTPEPYILPGTKTPMVNHATGCEKASLLYALQVSCNSVFAHMGDKVGRDGMVETAQKFGFNSTIDTPVRAFASVYDKTMGKDGNALSSIGQFNTAATPLQMAMVTAAIANDGKLMKPYMVEQLTAPNLDTIEKHEPQEMSRPLSAANAQKVQQMMVNVVENGTGTSAKIKNVKVGGKTGTAQHGEKNAKRPYAWFISYAELPDGSSPVAVAVVIEDSDVKDREDITGGGLAAPVAKAVMEAVLKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2R6</accession>
    <name>A0A0F4I2R6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001774">
        <property type="protein sequence ID" value="KJY16222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16222">
        <property type="protein sequence ID" value="KJY16222"/>
        <property type="gene ID" value="VR44_40545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16122" checksum="35A71E296207BAB6" modified="2015-06-24" version="1" fragment="single">MGEFAAAHVAGVLSLEDAAKLVAARGRLMQALPSGGVMVAVQASEEEVRELLAGLEDRAGIAAVNGSASVVVSGAAEAVASVTERLSARGRKTKALSVSHAFHSPLMDPMLDAFRTVVDSVSFQAPELPVVSTLTGRPVTAEELRSADYWVSHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I312</accession>
    <name>A0A0F4I312_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001764">
        <property type="protein sequence ID" value="KJY16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16317">
        <property type="protein sequence ID" value="KJY16317"/>
        <property type="gene ID" value="VR44_40505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6898"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="10928" checksum="5B2AE3D61B635F54" modified="2015-06-24" version="1" fragment="single">MPGFLLRNFLLLAVESGAAALLRDPGTPWIPVLLAVFVAGSAVPHGTEAELGGRFLVALTAVGVALAGAGAWEGHGLAATAGLAVLLLVQTAALLRLSRGGRGRPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4T9</accession>
    <name>A0A0F4I4T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001864">
        <property type="protein sequence ID" value="KJY15781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15781">
        <property type="protein sequence ID" value="KJY15781"/>
        <property type="gene ID" value="VR44_40835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6534" checksum="448C8DA47D809FEF" modified="2015-06-24" version="1" fragment="single">GAIGVAGRLLTGRAESGTVSTTTLGGPPAWTESRMLFAGAPASVLDATGTTTTTALGLDAHLHTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9N3</accession>
    <name>A0A0F4I9N3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">VR44_39440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="JZWV01001587">
        <property type="protein sequence ID" value="KJY18765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952511.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001587.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18765">
        <property type="protein sequence ID" value="KJY18765"/>
        <property type="gene ID" value="VR44_39440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5977"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY18765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22205" checksum="B4AAA884B4477515" modified="2015-06-24" version="1">MSDGKSVFVKICGLKTPEDVDVAVEAGAHAVGFVLAPNSPRTIDAARARELAARVPDGVLTVGVFRKQPLEEVRRLTEESGVRGVQLHGDEGPEYYEALRAPGLTLLRATAEHVARCGEYGEDLLLIDAPDPGSGKPWNWGSAEFTAPEGRWLLAGGLGPGNVREAVRATGAWGVDVSSGVERERGVKSPELIRAFIDAATHSYDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICK3</accession>
    <name>A0A0F4ICK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001540">
        <property type="protein sequence ID" value="KJY19737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19737">
        <property type="protein sequence ID" value="KJY19737"/>
        <property type="gene ID" value="VR44_39010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5562"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19830" checksum="BE3D1E188AC70B0C" modified="2015-06-24" version="1">MAEHQEDQWKVQTTDGQIFLTMMSPTAPHGLNVVRLRRQVEAQTPEVMALNDTNMGDPVTGLTKVPDLMVIAEEDTDDTAKVVNSRDVLMVVEVVSRTNSLTDIRDKLHDYPRMGVPLYVVVDPRKDKKTVTVHSDPSEGPDGIRYRKKVPHAFGDTVTAGRWTLDTSSLKSYPADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFD6</accession>
    <name>A0A0F4IFD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_38590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001490">
        <property type="protein sequence ID" value="KJY20722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20722">
        <property type="protein sequence ID" value="KJY20722"/>
        <property type="gene ID" value="VR44_38590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5393"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY20722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="14703" checksum="8826FBB748D19924" modified="2015-06-24" version="1" fragment="single">AFRDLGFDSLTAVELRNQLGAATGLRLPASLLFDHPTPAALAGHLAGALPAGGPGGDAPAPSLLAEIDRLETAFARAPQDRATRATAALRLEVLLAKWREASAGPGTGTGPVPGHHTGEGAEAEVAQASDEELFDLLDGELDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFZ7</accession>
    <name>A0A0F4IFZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001476">
        <property type="protein sequence ID" value="KJY20945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952326.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001476.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20945">
        <property type="protein sequence ID" value="KJY20945"/>
        <property type="gene ID" value="VR44_38465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5343"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY20945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22817" checksum="D1DCD9E732212E98" modified="2015-06-24" version="1" fragment="single">YILQLRRRLGTAMGPGRPGAAKEVLTTRHGGYLLQVPPGAVDVNVYEELVARGQAAFDGGDDEGAAGLLREALALWQGPALVDVRVGPVLEIEVMRLEESRLVTVERRIDADLRLGRHAELLAELTELGARYAQHEGLHSQLMVALYRSGRQASALDVYRRLRGRLIGELGVEPSPQLQRLHQAMLKTDPALDVVAGPKRGSTFDLYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGF0</accession>
    <name>A0A0F4IGF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001540">
        <property type="protein sequence ID" value="KJY19736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19736">
        <property type="protein sequence ID" value="KJY19736"/>
        <property type="gene ID" value="VR44_39005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5561"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="21719" checksum="8AEC14F13EC07144" modified="2015-06-24" version="1" fragment="single">MIDAGIRHLGELAVSAQGLGCMGMSHGYGDSDDAQSIATLNHALDLGVTLLDTADFYGAGHNEELIGRAIAGRRDEAVIATKFGFANRLGEPVVIRGDAAYVREACEASLRRLGVDHIDLYYQHRVDPQVPIEETVGAMAELVQAGKVRHLGLSEAGAETIRRAHAVHPITALQSEWSLWTRDLEAEVAPVCRELGIGLVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKE6</accession>
    <name>A0A0F4IKE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS fructose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001438">
        <property type="protein sequence ID" value="KJY21938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952262.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21938">
        <property type="protein sequence ID" value="KJY21938"/>
        <property type="gene ID" value="VR44_38110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5226"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="12511" checksum="CD2A37E04885A89D" modified="2015-06-24" version="1">MTPVGIVLVSHSAQVAESVAQLARGLAAGGAVAPVAPAGGSPDGGLGTSAELVLAAAAAVDQGAGVALLADLGSSVLTVKALLEDGDLPPNSRLVDAPFLEGAVAAVVAASAGAPLEAVAAAATEAYDYRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKM8</accession>
    <name>A0A0F4IKM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001418">
        <property type="protein sequence ID" value="KJY22552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952219.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001418.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22552">
        <property type="protein sequence ID" value="KJY22552"/>
        <property type="gene ID" value="VR44_37890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="40"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29374" checksum="352FB5AEEF87825C" modified="2015-06-24" version="1">MSNAHETAVYTHGHHESVLRSHRWRTAANSAAYLIGELRPGMRVLDVGCGPGTITADLAELVAPGGRVTAVDAAADVLDSAAAYAAERGLEGAVDFAVADVHALEFPDDSFDVVHAHQVLQHVGDPVQALREMRRVCRPGGIVAVRDADYAAMTWYPATPGLEEWQDLYHRVARANGGEPDAGRRLLSWARAAGFTEVRATATAWCYATPEEVTWWSALWADRTTASSYAEAAVGGGHATKDDLSRVAGAWRAWGAEPDAWFSVLNGELLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPF4</accession>
    <name>A0A0F4IPF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001334">
        <property type="protein sequence ID" value="KJY23907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952035.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001334.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23907">
        <property type="protein sequence ID" value="KJY23907"/>
        <property type="gene ID" value="VR44_36885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4692"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="22630" checksum="20FFB5C2AC86CE20" modified="2015-06-24" version="1" fragment="single">DLPEAGAAGPPGVTDEAPAGAEAGRVGALFADGLEGGHFCTASVVRSLGHDLIATAAHCLDHPDTTVFAPGYRDGEAPYGVWRLTRVWVAPGWADGRDPDEDIAFATVAPADGGETRAVEDVVGAFPVAAAQPGDVTVTVLGYPSVQDGPLRCSNATSLFSPTQRRIDCPDLSGGTSGSPWLAGGALAGVLGGYQGGGDFPEVSYSAVMGDAAMALYCEAAGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ16</accession>
    <name>A0A0F4IQ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001294">
        <property type="protein sequence ID" value="KJY24092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene17"/>
    <dbReference type="EnsemblBacteria" id="KJY24092">
        <property type="protein sequence ID" value="KJY24092"/>
        <property type="gene ID" value="VR44_36325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16067" checksum="462B91250EFB0D83" modified="2015-06-24" version="1" fragment="single">MTPGSNLPLNTTVVTVDVAAPVRLDVSGLLLAADGKVRSDADFIFYNQPTGPGVSYRSGGGAAPDSITVDTGALPPGIERIVVTASPDAPGQSFQGIEPTATVREAAGGAVIATFTPPRLGTETALVVVEVYQRGGVWKVRAVGQGYANGLAGIATDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ29</accession>
    <name>A0A0F4IQ29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001363">
        <property type="protein sequence ID" value="KJY23784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952106.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001363.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23784">
        <property type="protein sequence ID" value="KJY23784"/>
        <property type="gene ID" value="VR44_37270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4846"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="18289" checksum="CDF18C24053B47F6" modified="2015-06-24" version="1">MSSSLRLVPVTPANFDAVCAVRVHPDQEHLVSPVMKSLAEAYVHGDTAWPRAIVDGDEVVGFVMAFMDYPWAKDPQDIRSGLWRLNIAADRQGRGYGRFAVEAVTEEIRRRGGRRVYVTWKPAENSPEPFYLGLGFHRTGEFSDDEPVGVLHLDPTPNLSPDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQN9</accession>
    <name>A0A0F4IQN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001319">
        <property type="protein sequence ID" value="KJY23974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23974">
        <property type="protein sequence ID" value="KJY23974"/>
        <property type="gene ID" value="VR44_36695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4648"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="585" mass="63162" checksum="32303EA2AF6E0EA0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQX3</accession>
    <name>A0A0F4IQX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001301">
        <property type="protein sequence ID" value="KJY24064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24064">
        <property type="protein sequence ID" value="KJY24064"/>
        <property type="gene ID" value="VR44_36425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4537"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="13836" checksum="0709F3422D79DA37" modified="2015-06-24" version="1" fragment="single">MTSTAAPPVEESTAPGADGTRAPLTSGRGPAPADRHTRRFGLPVAICLVMGNVIGGGIFLLPASVAPFGTISLLAFAVLTVGAIALALVFGRLAERHPQTGGPYVYVRAAFGDFAGFLAAYSYWMTAWVSNAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRF1</accession>
    <name>A0A0F4IRF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001304">
        <property type="protein sequence ID" value="KJY24048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24048">
        <property type="protein sequence ID" value="KJY24048"/>
        <property type="gene ID" value="VR44_36475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="10410" checksum="832FDF586A7226C1" modified="2015-06-24" version="1" fragment="single">MASGAALSASALSKNLSGERLPHRSTIEAIIQLCGVSEEVRALSLRLHTAALGEVHPAFAERLVMADAYEEIVLLYNRLQARLEDVLGEQRRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRI7</accession>
    <name>A0A0F4IRI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001254">
        <property type="protein sequence ID" value="KJY24284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951829.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001254.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3144"/>
    <dbReference type="EnsemblBacteria" id="KJY24284">
        <property type="protein sequence ID" value="KJY24284"/>
        <property type="gene ID" value="VR44_35810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4317"/>
    <dbReference type="eggNOG" id="COG3396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="25648" checksum="9375B0C95AF8D53B" modified="2015-06-24" version="1" fragment="single">AAALASLGIWFEIILMQLLVRHIYDKPLTSNHVRYALTEIADECRHSMMFARMIQTGGAPAYPVSRANHNLARILKTISTTPGSFACTLLGEEILDWMQRLTFPDERIQPLVRGVTRIHVIEEARHVRYAREELRRQMLTAPRWERELTRLSCGEAARVFSLAFVNPAVYDNVGLDRREAVAQVRASGHRREVMQTGAKRLTDFLDDIGVLRGAGRRLWKSSGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISE0</accession>
    <name>A0A0F4ISE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001203">
        <property type="protein sequence ID" value="KJY24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24569">
        <property type="protein sequence ID" value="KJY24569"/>
        <property type="gene ID" value="VR44_34975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="26825" checksum="90AB0CBD241AAC7E" modified="2015-06-24" version="1" fragment="single">MPEFRVSRPDPAEVRARLASDRFLLVDVELPEEGLAGEAPQEAPAEEESVADALGLDFDGLDWFGRAQEQPRAEYLGDWSGVVAPVVRGDRITHVHVLVTERFLILVRRGQGDHVRGFLERLSRQDADDTVAVLFFLLGETLGTFRRAAVQALLEAEAIEDDMFDERRPEQLYRLTLLRRRSAQLHHFLRPFLDVTDEVLTRRMLSPAFPEGRRRLAQEFQTRGRLVLADIESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISI6</accession>
    <name>A0A0F4ISI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001143">
        <property type="protein sequence ID" value="KJY24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951472.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001143.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24952">
        <property type="protein sequence ID" value="KJY24952"/>
        <property type="gene ID" value="VR44_33865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3697"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32357" checksum="9BF6560493DC55DB" modified="2015-06-24" version="1">MNTTPKPSRPASRLRRELRREVPSTVGLLADARDFAAMRDYRSFAFDHHDEYADYLRHVDALLRSLAAQGIHTTVALFDPDEYADYCADHGLDPDSAPTRTRFTAELACGPALPYTGQPVEELVPLLVDAAVRQATWEYAGAVLAGVGECADCGEDIGRASFERATALVRRLVDGAGPGHHHLVCSIPTEEQQLIAVLHAEAAREPGGPLRAEGRDQLDFVTVLAAGLALGGSGGLVLRSSTDDCHDRVHGWRLDHGRLLPLSAAAVFDAYCTDADTGDPVAPEPGVEYCPGYEVDGPAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISS1</accession>
    <name>A0A0F4ISS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001215">
        <property type="protein sequence ID" value="KJY24508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24508">
        <property type="protein sequence ID" value="KJY24508"/>
        <property type="gene ID" value="VR44_35125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="15869" checksum="9A75728DD7476CEF" modified="2015-06-24" version="1" fragment="single">MESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQGPGGNAGKSAAKPGAPRKAAPAKPAAPSPATAARPAPKPGAPAPKPAAAEAPAAPAPVTPAAPGPRPGPKAPAAPKPAPAAPVATEFSAPPAAPGRPAATPGPRPTQQRPAAPGQSGARPGAPRPAGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISU3</accession>
    <name>A0A0F4ISU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001126">
        <property type="protein sequence ID" value="KJY25062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951419.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001126.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5678"/>
    <dbReference type="EnsemblBacteria" id="KJY25062">
        <property type="protein sequence ID" value="KJY25062"/>
        <property type="gene ID" value="VR44_33560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3594"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="27418" checksum="E944D1D94EBC085F" modified="2015-06-24" version="1">MGNSEGNGRRRPEEQQLGPVLRRRGQVQAGSTTDQRLLDSAGPSEWVHTDPWRVLRIQSEFIEGFGTLAELPPAISVFGSARTPVGSPEYEAGVRIGSALVEAGFAVITGGGPGAMEAANKGAREANGISVGLGIELPFEQGLNQHVDLGLNFRYFFVRKTMFVKYSQGFVVLPGGFGTLDEMFEALTLVQTQKITRFPIVLFGTEYWGGLVDWLRNTVIAQGKASEKDLYLFHLTDDVDEAIALVTKEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUE8</accession>
    <name>A0A0F4IUE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylinositol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001099">
        <property type="protein sequence ID" value="KJY25269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951303.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001099.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25269">
        <property type="protein sequence ID" value="KJY25269"/>
        <property type="gene ID" value="VR44_32960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3412"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="28679" checksum="E24A93C4310A7514" modified="2015-06-24" version="1">MTPIEELLTRGELTVRGRIAEASNAVLLCTVAYEGRSAECVYKPVKGERPLWDFPDGNLARRERAAYLVSEATGWGLVPTTVLRDGPYGEGMVQHWIDAGEQPEPQLLALVEGEEAGEGWKAVAFAEVGEGRTALLVHADDPRLRRLAVLDAVINNGDRKGGHLLPAPDGRLYGIDHGVTFHSEDKLRTLLWGWAGEPLTDEARSVLSSLEAQLAEDAPLTTRLAELITPAELAAVRARVALLLRSGTHPKPSGQWPSIPWPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUV5</accession>
    <name>A0A0F4IUV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001022">
        <property type="protein sequence ID" value="KJY25810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951049.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25810">
        <property type="protein sequence ID" value="KJY25810"/>
        <property type="gene ID" value="VR44_31555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2807"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19464" checksum="AE023CA85A26C638" modified="2015-06-24" version="1">MDPPPAVDWAKAERALGTGLPADYKRLVGTYGAGIFDETVQLLVPDSAHDDFDLLALTAERDEILAGLWEYEDRPPGLEEAGARVLPWAAEEGTGAYLYWLARPGRHPDEWTVLYNEGRGPLWEHHDTGCLAFLLAVLTGTAETDYFGHLHEVLKPTRHRFTTAAETHGTPCAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVG7</accession>
    <name>A0A0F4IVG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001182">
        <property type="protein sequence ID" value="KJY24686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951603.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001182.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24686">
        <property type="protein sequence ID" value="KJY24686"/>
        <property type="gene ID" value="VR44_34585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3902"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="246" mass="25264" checksum="8B40B5542347AC6F" modified="2015-06-24" version="1">MATKNIPDPGFSDDDGTADPRLSAALAAWAEDRSREPELLAALKDARLLVPVVAMLGEVETDPETGLKREKTSDMAVPTLTAGDRRALPAFTSIASLALWDPAARPVAVPLHQALAAAVHEKADTIVLDLAGPVPYQLTGPALLALAEGRTDADPLADPAVRQAVRAAVAAEPAVLRAHLGPGGASADGTLAIVLSEGEPVAPAARRVAEALAADETLRGRLVRGLDLALLPAGAPVPPGEPLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVP8</accession>
    <name>A0A0F4IVP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001060">
        <property type="protein sequence ID" value="KJY25533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25533">
        <property type="protein sequence ID" value="KJY25533"/>
        <property type="gene ID" value="VR44_32230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3167"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="9941" checksum="A3ADA1EB14F03C72" modified="2015-06-24" version="1" fragment="single">ELLPLPATLRAAAGWWKSHRAPLIALAKRVPAVRGTLLGMVPGGTGEAGELSALWLEVLEESGASAGLTDPGLPEAERSPDGTAGWLERFHAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX05</accession>
    <name>A0A0F4IX05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000974">
        <property type="protein sequence ID" value="KJY26179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950894.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000974.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5076"/>
    <dbReference type="EnsemblBacteria" id="KJY26179">
        <property type="protein sequence ID" value="KJY26179"/>
        <property type="gene ID" value="VR44_30730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2602"/>
    <dbReference type="eggNOG" id="ENOG503487A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="7237" checksum="E5A5206F15778A19" modified="2015-06-24" version="1">MQAAPVRAIAIPSFTEAFRGIESLLMSGARRNAWTAVLEDRRRAKDRVETEHVLEAAATRTPQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXH0</accession>
    <name>A0A0F4IXH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000907">
        <property type="protein sequence ID" value="KJY26735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950631.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000907.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26735">
        <property type="protein sequence ID" value="KJY26735"/>
        <property type="gene ID" value="VR44_29290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2209"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470517" evidence="1">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13611" checksum="BFC30F6845F9682D" modified="2015-06-24" version="1">MGRSLARVLPVVRVLSGTLAVTMVPWADNSPSQILTASAEDVSVPAKPRAAQDVLRDKLLSELQQGENPGVVLGHLQEQVNGRPSLAEHCMGIARALGRAAVEAYGPTKAQSYSRPVCDTSYASGVASMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXP6</accession>
    <name>A0A0F4IXP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligosaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000967">
        <property type="protein sequence ID" value="KJY26238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950868.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000967.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26238">
        <property type="protein sequence ID" value="KJY26238"/>
        <property type="gene ID" value="VR44_30590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="26496" checksum="5F516E18FE6943DF" modified="2015-06-24" version="1">MTNDEPTVGRRVLLRTAVFLGIAAAASSGLLSGGEGGPTAGPSGTPPGGAPEPARGPGAAGAPGAHPEGHPDASHRLQPMTAEAPARPPAGKPAVRTRPILELPQGPAAGDRAMLLTFDDGPDPRYTPAILDTLRRYGVRAMFFVCGEMATDNRDLLRRMAAEGHVIGNHTWTHPQIPQLTRSALESEIGRTSEVVEQAVGAPPLWLRGAPGVIVLNHDAGGNRSQSVRALETYLPQLLGRGYRMTLPVLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXT1</accession>
    <name>A0A0F4IXT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_30065</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000939">
        <property type="protein sequence ID" value="KJY26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950773.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000939.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="EnsemblBacteria" id="KJY26444">
        <property type="protein sequence ID" value="KJY26444"/>
        <property type="gene ID" value="VR44_30065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2397"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="230"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="517"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="836" mass="91650" checksum="7144AAAE14E93D44" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY83</accession>
    <name>A0A0F4IY83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26990">
        <property type="protein sequence ID" value="KJY26990"/>
        <property type="gene ID" value="VR44_28680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2067"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470244" evidence="1">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="17900" checksum="E4D20E5D3A4F8792" modified="2015-06-24" version="1">MSGALLAAHLLVVGWLTLSPLDVPWAAAANLSPLEGIRADLALGPLEAARRIGEGLALLAPLGVLLPLAGGRLKPGALAAWSSLVRTAAAAVLISLGIEMLQTAVPGRVLDVDSLLLNTAGVVLVHVAVVPVLRARLRRPLTSPDAGPQGNTPRIPRVGLGPWTDVLSAVPREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYG2</accession>
    <name>A0A0F4IYG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000933">
        <property type="protein sequence ID" value="KJY26493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26493">
        <property type="protein sequence ID" value="KJY26493"/>
        <property type="gene ID" value="VR44_29925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11703" checksum="EAE1ED5B5FD7177E" modified="2015-06-24" version="1" fragment="single">MPTCPNGHQSAADDWCEVCGHRMAAPVSPPAYPPTTGEPTAQAELCPRCRTPREAMAPFCEECRYNFLTRTATPHTPPPAPPVPDAGPYPSSGWQPPADGAPPSPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYR4</accession>
    <name>A0A0F4IYR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000918">
        <property type="protein sequence ID" value="KJY26608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26608">
        <property type="protein sequence ID" value="KJY26608"/>
        <property type="gene ID" value="VR44_29640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2308"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="24953" checksum="992DB29A1831BF11" modified="2015-06-24" version="1" fragment="single">APAAPGRRGGPGGGLPLGEVREECRGLARAAVRLDGPAMEALLQRTVRAHGLVAAWEEVMVPTLHAVGRKWESTQDRYVEVEHLLSWHVSTVLRRVPGTVPGPPAHLAPVVLACLPGEQHTLPLEALAAGLAERGLPARMFGAAVPPEALRAAVGRSGPAAVVLWSQSRTTADAALARQVASTAFGLKGARTAPVVFLAGPGWPVRAVTAGMRRPRGLREALDAISALYAEPVVPGTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J045</accession>
    <name>A0A0F4J045_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_30370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000957">
        <property type="protein sequence ID" value="KJY26296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950827.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000957.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26296">
        <property type="protein sequence ID" value="KJY26296"/>
        <property type="gene ID" value="VR44_30370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2486"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="7">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="290" mass="31073" checksum="16CF6BDF3FFCEA29" modified="2015-06-24" version="1">MPIDAARALAADPRQGEIGWDHKDVQLYHLGLGAGSSLHGNSLATDPDELRYTLESKLHVLPSFATVAGAGMAMLGGLAAPGIEVNLANVLHGGHSIELHRPIPVKGRATSSSKVAAVYDKGKAAVIVLRSEVADADGPLWTSDAQIFVRGEGGFGGDRGPSVREELPDRAPDRTEERPIREEQALLYRLSGDWNPLHADPEFAKLAGFDKPILHGLCSYGMTLKAVVDTVLGGDVSRVRAYRTRFAGIVFPGETLRIRMWQEPGRVLVSVTAAERDDAPVLADTIVEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0E5</accession>
    <name>A0A0F4J0E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000859">
        <property type="protein sequence ID" value="KJY27198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2564"/>
    <dbReference type="EnsemblBacteria" id="KJY27198">
        <property type="protein sequence ID" value="KJY27198"/>
        <property type="gene ID" value="VR44_28200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8614" checksum="10418E94BC6D92D4" modified="2015-06-24" version="1" fragment="single">RRPDPADAADPGRAPAPPPAEPAAGYRTEQFAFLDQPDEDSEDVIDWLAFTESRTERREEARRRGRNRVVALVVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J129</accession>
    <name>A0A0F4J129_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000833">
        <property type="protein sequence ID" value="KJY27443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950317.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000833.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000024_gene6484"/>
    <dbReference type="EnsemblBacteria" id="KJY27443">
        <property type="protein sequence ID" value="KJY27443"/>
        <property type="gene ID" value="VR44_27550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1745"/>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="44520" checksum="CB7037EF87BC0AD6" modified="2015-06-24" version="1">MRVLLVGAGGVGTAITRIAARRDFFDHFVVADYDLARAEAAVTALGDAAGRFTARRVDASDEAAVAALLTEERCDVLLNATDPRFVMPLFEAALAADSHYMDMAMSLSRPHPGLPYSECGVKLGDEQFARAEAWEKSGRLALVGMGVEPGLSDVFARYAADELFDEIEEIGIRDGANLTVEGHEFAPSFNIWTTIEECLNPPVVWERDRGWFTTEPFSEPEVFDFPEGIGPVECVNVEHEEVLLVPRWVDARRVTFKYGLGEDFIGKLRTLHALGLDSTAPVTVRGADGAPVRVSPRDVVAACLPDPATLGGRMSGKTCAGTWVKGTKEGWVREVYLYHVVDNQWSMREYGSQAVVWQTAVNPVVALELMAGGVWARSGVLGPEAFAPRPFLDLLTEYGSPWGVREQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2U9</accession>
    <name>A0A0F4J2U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000720">
        <property type="protein sequence ID" value="KJY28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949858.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000720.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28540">
        <property type="protein sequence ID" value="KJY28540"/>
        <property type="gene ID" value="VR44_25100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1112"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470070" evidence="1">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15559" checksum="7C3BF39A70EB2B8F" modified="2015-06-24" version="1">MLVRKLKAAAVAATAVASAAVMATPAQAGAAYCSHGGGAYLCEYSPTTRVLPNGTKQDFVVGTDRAVWTRWTDSDGDWSRWISMGGKAYSKVYTYDYDTSDPWSFRMFYYDQQAEYWGRNRDHDGNWSGWIHYDTPLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3G0</accession>
    <name>A0A0F4J3G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949685.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28912">
        <property type="protein sequence ID" value="KJY28912"/>
        <property type="gene ID" value="VR44_24155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.783"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14244" checksum="DF927E39C1D10C77" modified="2015-06-24" version="1">MSEKTAVTPDSHPAAPAKFSHGVRKGNILQVAGQVGQLPAVAGQAPAIAGPTLREQTLQTLENVRSVLEAGGASWDDAMMIRVYLTDTAHFAEMNEIYNAYFDEQAVKVPAARTTVYVGLPAGLLIEIDALAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J406</accession>
    <name>A0A0F4J406_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_23755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949611.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene196"/>
    <dbReference type="EnsemblBacteria" id="KJY29087">
        <property type="protein sequence ID" value="KJY29087"/>
        <property type="gene ID" value="VR44_23755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.724"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="164"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="424" mass="44640" checksum="435897735C91DF60" modified="2015-06-24" version="1">MDVNAAVAAAAAIAGLCTGVIAMLAFRWSERDQARPTRSSMRPDINAVLPPGVDTVLSVLRSSAVVLDEGDAVVKASSAAYALGLVRGGKLAVEPMLHMARDTRRDGEIRQIELDLPRRGTGRGEALAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANVSHELKTPVGAISLLSEAVMDAADDPEAVSRFAGRMQIEATRLINLVQELIDLSRVQNDDPLEDAEPVRVDTLVAEAIDRCRHTATSKQITMAAGGTADLRVWGHRGQLAAALGNLVENAVNYSPARTRVGIAARRVTAPGGDLIEIAVTDQGIGIPEKDRERIFERFYRVDPARSRATGGTGLGLAIVKHVAASHGGEVSVWSSEGQGSTFTLRLPEAGAPAPAPAPDTTGAAAEATAPGPARPPLDPETVVPSPEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J496</accession>
    <name>A0A0F4J496_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000799">
        <property type="protein sequence ID" value="KJY27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27761">
        <property type="protein sequence ID" value="KJY27761"/>
        <property type="gene ID" value="VR44_26815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1521"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="191"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29627" checksum="9FB34716E80E394F" modified="2015-06-24" version="1" fragment="single">RFDAGAVLDAFLEHRPAYTIGPATAFTALAAHPAATREHFASFQVISSGGAPLPPALVERLRADFGFYLRNGYGLTECTAPCASVPAHREAPVDPGSGTLSVGVPGAQTLVRILDEHGGELPLGQTGEIAVRGPQVVPGYWGLPDETAAAFPDGELRTGDVGFMDADGWLYVVDRKKDMISASGFKVWPREVEDVLYTHPAVREAAVVGVPDAYRGETVTAYVSLRPGTRAEPAELVAHCAERLAAYKYPRRVEILPVLPQTTSGKILRRELRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4I3</accession>
    <name>A0A0F4J4I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949789.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28739">
        <property type="protein sequence ID" value="KJY28739"/>
        <property type="gene ID" value="VR44_24700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.937"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="30885" checksum="133396A24758B332" modified="2015-06-24" version="1">MPQSNRPKRNASWKVVGVLLAHQRKRAGYTQVQLAELAFCDVESIASVEQGRRPLSVRMAEVLDNHLDSKGVLHDAAAAIPRRERYPAFAREYMEHEEEALSLFSYENAAVPGLLQTPEYAAAVFSNFYPPMPTDQISQQTEDRIARQKLFQRAPQPPVMHFIVEQSLLERPIGGRAVLRGQLRHLRAMAELPFVGFQIIRTDRDSHAGLAGPLVLLETPDHDQLGYLEGQHVSFLQDDPDEVHLLHLKYGMLRSQALSIEHSKSLLDDLLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4K1</accession>
    <name>A0A0F4J4K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_24935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949828.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28643">
        <property type="protein sequence ID" value="KJY28643"/>
        <property type="gene ID" value="VR44_24935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.987"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="31617" checksum="D1DA55CF717A8020" modified="2015-06-24" version="1">MNSVLYDVPGPKAKARNWIYTAVFLVLFALAAWWILSVMADKHQLDADKWTPFVTDGRVWTTYLLPGLGETLKAGAIAMVIALPLGALLGIGRLSDHAWVRGPVGTVVEFFRAIPVLMLMMFGYAFFVKFVPAVASDFRPLYAVVTGLVLYNSAVIAEIVRAGVLSLPRGQTDAAKAIGMRKGQTMVHVLIPQAVTAMLPALVSQLVVILKDTALGGSLLGLTDLLAANRQISANYTNTIASLVVIALIYIAVNFALTSFASWTEGRLRKSKKSTGAVVAVAEVDDLATGANSAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5S9</accession>
    <name>A0A0F4J5S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_22680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949417.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000066_gene6660"/>
    <dbReference type="EnsemblBacteria" id="KJY29545">
        <property type="protein sequence ID" value="KJY29545"/>
        <property type="gene ID" value="VR44_22680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.468"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24593" checksum="5DD05E429A12FB14" modified="2015-06-24" version="1">MRVLVVEDEEFLREMIAEGLRRDALAVDEAGDGLEALRRLRLGEYDVLVLDRDLPGLHGDEVCRQIVRERLLTRVLMLTASGTVRDRVEGLGLGADDYLTKPFSYDELLARVLALGRRAHPALPPVLERCGVAVDTARRTATRDGRRLALSRKEFAVLEALLRAEGAVLGNDDLIEQVWEQDTSYRTNAVRVTLSKLRAKLGEPQLIETVPGAGYRIADPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6T1</accession>
    <name>A0A0F4J6T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28636">
        <property type="protein sequence ID" value="KJY28636"/>
        <property type="gene ID" value="VR44_24900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.980"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11951" checksum="AC26DC40F725BCD7" modified="2015-06-24" version="1" fragment="single">EYGLGLLTNDRRPKPAGAAVARIAAAWRGREHRPPVRSTALALDTGSGQSVCAPGGAFFEAWAVLAAKGVRPAVVRAEHAQDPGRLAARGITEVLRVRDVVAGPDRPAPTRPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Q7</accession>
    <name>A0A0F4J7Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_20945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949090.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30235">
        <property type="protein sequence ID" value="KJY30235"/>
        <property type="gene ID" value="VR44_20945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8919"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25554" checksum="0AE6741BD997B6D7" modified="2015-06-24" version="1">MAVYVYAVTRREHPCRLGGLTGVGPDAPAVRTLDSGELRAVVSDVGEAIRPKRRDIAAHQAVLDRLMADETPLPLQFGYTAPDDETVRQVLAERADGYLDALAGVQGCAEYNVKARQDEGVLLRGILEDSPRASGLNEEILAGDTDPRLPLELGQLVAAEVDRRSSNASADLIRALAPLARAYVVHPPTGEDFVNLSLLVPRDGEGAFLDAHTGLTREVDTGVRTRLTGPLPPYSFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J821</accession>
    <name>A0A0F4J821_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">VR44_23775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949613.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29091">
        <property type="protein sequence ID" value="KJY29091"/>
        <property type="gene ID" value="VR44_23775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.728"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="25963" checksum="7F2CF20D59252AF3" modified="2015-06-24" version="1">MSDESRPHRTAAVIPAAGRGVRLGPGAPKALRALGGTPMLVHAVRAMARSRAVSLVVVVAPPDGAAEVRHLLDEHPLPERTDVLVVPGGDTRQESVRAGLDALPADITSVLIHDAARPLVPVDTVDSVVEAVRDGAPAVVPALPLADTVKEVEPGRPGEPEPVLGTPERSRLRAVQTPQGFDLKTLLHAHETIAVNGEGATDDAGMVERTGVTVVVVPGHEEAFKVTRPLDLVLAEAVLARRRATDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J835</accession>
    <name>A0A0F4J835_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29939">
        <property type="protein sequence ID" value="KJY29939"/>
        <property type="gene ID" value="VR44_21620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.202"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8934" checksum="5BDD893AC937B7A0" modified="2015-06-24" version="1" fragment="single">MTTPAAPAPARMPALYLSHGAPPLADDPLWPAELAAWSAGLPRPRAILMVSAHWEEAPLALGATEPAPLVYDFWGFPEHYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J846</accession>
    <name>A0A0F4J846_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000673">
        <property type="protein sequence ID" value="KJY29121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29121">
        <property type="protein sequence ID" value="KJY29121"/>
        <property type="gene ID" value="VR44_23670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.679"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="8912" checksum="EF7413C7FED955C2" modified="2015-06-24" version="1" fragment="single">LAAATAVPDEEVAGILEAAAASATRRGGALTAVTWLSRAAELSENPDGRSRRLAEAAFVAGHAARPGHAHRLARTGLAPGAAQPPGAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8U2</accession>
    <name>A0A0F4J8U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000585">
        <property type="protein sequence ID" value="KJY30163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30163">
        <property type="protein sequence ID" value="KJY30163"/>
        <property type="gene ID" value="VR44_21075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="19008" checksum="29585246B8A4E73B" modified="2015-06-24" version="1" fragment="single">MRDAGRGNTGNPPSGRHARAVDGAPVRIGALAPLTRPGWTEAGRHLVAGLRLAADEVNAAGGIAGRPLELAVRDTAADPQRAAAAVDELAGLGVAALAGEYHSVSARAAAARADALGLPFLCSSAVIDALTEHPAEAVARLAPAQSHGWRTYADFLVGGGHSRIAVAAEASVYWAAGTRVLREHLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J910</accession>
    <name>A0A0F4J910_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxycytidine triphosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000643.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29421">
        <property type="protein sequence ID" value="KJY29421"/>
        <property type="gene ID" value="VR44_22945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.526"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19673" checksum="E81B5DF05F6C9AE4" modified="2015-06-24" version="1">MILTGPAIAAARDAGHITIDPYEPDRLSPNAYDWRLGSILRVCQGDLDAAAPTTFRELTLPDDGYVLEPDNLYLGHTLERTGSETYAQLLNGDRTTGCLGIWVHVSAPLGHQGHAIRWTLEIRATRPVRVRPGMTFGKLVFLRTHGTPASYQQHGLKYRTSEGIETSRLYEENPGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC03</accession>
    <name>A0A0F4JC03_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TP_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000499">
        <property type="protein sequence ID" value="KJY31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31339">
        <property type="protein sequence ID" value="KJY31339"/>
        <property type="gene ID" value="VR44_18355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="7864" checksum="BEEF91C43E845EE4" modified="2015-06-24" version="1" fragment="single">MNPSSPTTSAFPAVAVQGLVTFLGAGPGDPGLLTLRAVEALAAADVLIAEPEVLDVVRTHARAGVDTPQLTVADEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCU8</accession>
    <name>A0A0F4JCU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948513.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000483.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31558">
        <property type="protein sequence ID" value="KJY31558"/>
        <property type="gene ID" value="VR44_17875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8118"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="23305" checksum="C513F4882E25F364" modified="2015-06-24" version="1">MSEIAGIKIPDSKLAKEATELIREATDDLIYHHSRRVFVWGALQGANRGLSFDPELLYVGAMFHDLGLTEPYRDNDQRFEIDGADEARKFLLARGVDADSARIVWEAIALHTTPEIPTRMAPEIALVTAGVELDVLGLGYHDVSEETRAAVVAAHPRPDFKNNILQAFNDGITRRPGTTFGNVKADVLAAYTDGYVRPNFVDVIKNSAWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE28</accession>
    <name>A0A0F4JE28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948651.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31246">
        <property type="protein sequence ID" value="KJY31246"/>
        <property type="gene ID" value="VR44_18565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8308"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="28"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="29185" checksum="C91B9E3D14AE7191" modified="2015-06-24" version="1">MPDQGYAAGGSGTGGTDGARPAPSAAAVRIEGLWKRFGEQVAVGGIDLELPAGRFIGLVGPNGAGKTTTLSMVTGLLRPDMGRVTVAGHDVWADPVEVKKRIGVLPEGLRMFERLSGRELLGYMGRMRGVSGEETDKRATQLLDVLDLAGSQHKLVVDYSTGMRKKIGLAAALLHNPEVLFLDEPFEGVDPVSAQTIRGVLERYTASGATVVFSSHVMELVESLCDWVAVMAAGQIRAAGPLADVRGSAPSLQNAFLELVGARDHAAGDSLDWLGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE29</accession>
    <name>A0A0F4JE29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948108.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32607">
        <property type="protein sequence ID" value="KJY32607"/>
        <property type="gene ID" value="VR44_15695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7541"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="15403" checksum="07E022EAEA122C3A" modified="2015-06-24" version="1">MSAVRYDLPEADDFTRPYWDAAAEGRLLLRRCADCGRAHHYPREFCPFCWAGEDRVGWEEASGRATLYTWSVIHRNDLPPFGGRVPYAAAVVDLEEGPRMMTEVVGCPEGELRIGMPLRVTFREAAEGVWVAVFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JES4</accession>
    <name>A0A0F4JES4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000492">
        <property type="protein sequence ID" value="KJY31451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31451">
        <property type="protein sequence ID" value="KJY31451"/>
        <property type="gene ID" value="VR44_18090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8165"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="36901" checksum="4C9536A9C0C6C676" modified="2015-06-24" version="1" fragment="single">AALGAGLYLCSGGKDLSNPADLDKAILSYNQSREYVNSVLGYMRQYQQDGTAGVPNPPVGNYPTPPAPHVPTAPHVPTPNPPASKPTPTPDPKPTPKPDPKPTPTPDPSKPTPAPAALAGLGQVGDAKLEAEAGSTFADGARFKAVLSDGKPAVGQAVVVAVEQDTTGGTGFVFVNEQSVVVRTDAQGIATAPRLKAGPKAGTFTLRATAYDSKGQFTVALAGKVTEKPAEKPVALTRADGGAAVEVAAGTSVKDLRFLAARDGKPEAGLKVTAELVTGKPGAWVPVDPKTAKGPFFKGGADGQKLFSVELPKTGADGKTVLPELLTTDAPAGTYHLRLTTADGAELIVDVTVTAPKTEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEV8</accession>
    <name>A0A0F4JEV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000385">
        <property type="protein sequence ID" value="KJY32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000023_gene6178"/>
    <dbReference type="EnsemblBacteria" id="KJY32887">
        <property type="protein sequence ID" value="KJY32887"/>
        <property type="gene ID" value="VR44_15050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7429"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26907" checksum="8CD1977E6C6F4C60" modified="2015-06-24" version="1">MARRTVDAHTDAGPGEDGIHTMGAAVMAADYRMFAGVNLYHFTGGPCAELVALGAARAQGARQMRCIVAVGNHGRGVIGPCGRDRQVFVDYYPTMRVIVPTPAGPRSVLAADLMPLTQRWTPEGMNGLDPSLYQDPETAGPPIIRFNPRYLEAVRSGAKTRTTRFRDPVRLGPARLVFESDPEVVLPAEVTHIRRCLVSELTDQDAQAEGLRTATELREVLKGHYPDLAGADEVDVITFQVDDRTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF13</accession>
    <name>A0A0F4JF13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B12-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948511.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000483.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31556">
        <property type="protein sequence ID" value="KJY31556"/>
        <property type="gene ID" value="VR44_17860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8115"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16627" checksum="FA7FD1A47024492A" modified="2015-06-24" version="1">MALPSTAKGSHPAHAGKPRVLVSSTSSDSHTWNLVFLQLLLEEMGNDVVNIGSCVPDDLLIAECRRHRPDMVVISSVNGHGALDGERLITALRAEPDLSRLPVVIGGKLGTRGSSVFGQRLMDAGFDAVFEDSAGIEPFRSYLELAPHAVELEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGB3</accession>
    <name>A0A0F4JGB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">VR44_13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007262928.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7197"/>
    <dbReference type="EnsemblBacteria" id="KJY33392">
        <property type="protein sequence ID" value="KJY33392"/>
        <property type="gene ID" value="VR44_13980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7097"/>
    <dbReference type="eggNOG" id="ENOG5032SI2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="14011" checksum="F9628D6AB7CA8E4A" modified="2015-06-24" version="1">MSERALRGTRLVVTSYETDRGIDLAPRQAVEYACQNGHRFEMPFSVEAEIPPEWECKACGAMALLVDGDGPEEKKGKPARTHWDMLMERRTREELEEVLAERLAVLRSGAMNIAVHPRDSRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGY2</accession>
    <name>A0A0F4JGY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33064">
        <property type="protein sequence ID" value="KJY33064"/>
        <property type="gene ID" value="VR44_14595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7620" checksum="638A9BBF50C10DE4" modified="2015-06-24" version="1">MNDSGALLPWLVIRQDDNGNRYRVGRYATRAEAQKVVDVFEDRGHEQLYWVERIGQADGSPAATSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH40</accession>
    <name>A0A0F4JH40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947910.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33068">
        <property type="protein sequence ID" value="KJY33068"/>
        <property type="gene ID" value="VR44_14615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7249"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="70"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="370" mass="38288" checksum="6A1532957BF8B62C" modified="2015-06-24" version="1">MTHALPDYLCSEDGTRADVRTAPWCCPVCGGPWDLDFTPDPAIPLEPAAGPHSLWRYAPALPLPGAFSVTLSEGHTPMLPLGDRIHAKLDFLMPTLSFKDRGAVMLAELARRLGPARVVADSSGNAGASVAAYCARAGLSCEVFVPEGTSEKKTAQMRAYGAEVRLVPGGREAAARAAGAVADEPGVFYASHVFNPWFLHGTKTYVYEIWEALGGRLPEVLVVPVGNGTLLLGAALAVAELGRRGVRAPALVGVQAEAVSPLAAAFAAGAEEAEPVPSRPTLAEGIAIPAPPRGRQILAAVRKSGGTILTVPDARIREAQRELARRGLFVEPTAAACWAAVGPGAPSDPLQGRTAVLPLCGAGAKSGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH50</accession>
    <name>A0A0F4JH50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000353">
        <property type="protein sequence ID" value="KJY33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947761.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000353.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33515">
        <property type="protein sequence ID" value="KJY33515"/>
        <property type="gene ID" value="VR44_13760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7030"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="18515" checksum="E39E78839D33A7D2" modified="2015-06-24" version="1">MNEHGIPGAPEGFTAFGVAADWPQSRQVTGHGHSRLSGDAHVYLWYGSPHFDPEVEHVTVCSASSGNPEAEEALRRGFEDYFHIDQAPWTSLPAPEPVTVTADGKPVGCELWRDSGRRCWVARGRAGAMELVLSGSGIDPEGLGLVSVSDLTCFSGHFGWRPGVAHPGGTQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHN1</accession>
    <name>A0A0F4JHN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosylmethionine synthetase</fullName>
            <ecNumber evidence="3">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000364">
        <property type="protein sequence ID" value="KJY33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3374"/>
    <dbReference type="EnsemblBacteria" id="KJY33324">
        <property type="protein sequence ID" value="KJY33324"/>
        <property type="gene ID" value="VR44_14125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9069" checksum="3EC5C61736498806" modified="2015-06-24" version="1" fragment="single">MSRRLFTSESVTEGHPDKIADQISDTILDALLAEDPTSRVAVETLITTGLVHIAGEVTTKAYAPIAQLVRDKILEIGYDSSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIN3</accession>
    <name>A0A0F4JIN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000391">
        <property type="protein sequence ID" value="KJY32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948017.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000391.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32826">
        <property type="protein sequence ID" value="KJY32826"/>
        <property type="gene ID" value="VR44_15205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22220" checksum="BF94A06D2D3CEBFE" modified="2015-06-24" version="1" fragment="single">MRIGFSVPQFGPFADPGRSAAMCTALEALGCHSLWVADRLLAPLTPPEGYPGGPMPVRYGTHLDPLLALGVAAAATERVRLGSSTLNALWQPPLVLARALTTLDLISRGRLEVGLGLGWMREEYEAAAVPWRGRGARLEETLDVLEAVWGSGPVAHTGRLWTIPPSTVLPKPLQSPRPPLLLGGFTPFALERVGRRADGWLAAAMPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJC6</accession>
    <name>A0A0F4JJC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947623.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33888">
        <property type="protein sequence ID" value="KJY33888"/>
        <property type="gene ID" value="VR44_13010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6720"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="243" mass="26630" checksum="C5CD3E152AE0FB26" modified="2015-06-24" version="1">MTDPRAAEPMLTVDELASKAGVTVRTVRFYSTRGLLPPPLIGPRRVGHYGPEHLSRLALIEELQHQGMTLSAIQRYLDALPDDLSAHDLAIHRALVATWAPDTPRVVSRAELEKRAGRALSDGDLRRLAAMNVLSEAGEGFRVDLALLRLGVALLDVPIAHETLLVARGILLEHARTAAHELTALFRDEVWGPFTEGESDLEQIESMKALSAHMQPMVVQALVTAFQRSLKEELRAAFASETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK73</accession>
    <name>A0A0F4JK73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947328.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34737">
        <property type="protein sequence ID" value="KJY34737"/>
        <property type="gene ID" value="VR44_11430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6183"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="22082" checksum="A3F2DFC917479409" modified="2015-06-24" version="1">MPDPDLPFPTVTQYASPDLISAIVYDGHDQGADPRWAESGAPDADTYRTWCGHMCGIACLRMALLARDGDAPSLFELLDGARTYGAYTEDPDTGAIRGLIYAPFARYVQAVHRLHAQVHPTLPVPDLLALLDSGRLVMASVHREIRRPENPAPGKGGHLVLVTGRRGDTVHFRNPSGHTDRTRTASLPVAAFAEFFAGRGVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKJ5</accession>
    <name>A0A0F4JKJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000299">
        <property type="protein sequence ID" value="KJY34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947468.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000299.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34298">
        <property type="protein sequence ID" value="KJY34298"/>
        <property type="gene ID" value="VR44_12185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6417"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16996" checksum="F99AB272ED524A2E" modified="2015-06-24" version="1">MTTEPTRPEHGALHHVEIWVPDLERAVASFGWLLEALGHTPFQSWADGRSWRLGATYLVLEQSPALTAGRHDRRRPGLNHLAFHVEDHHTVEALARRAAGHGWTLMFPDRHPHAGGERTYAAYLENADGFEVELVAITAPGARGSDTAPPAPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKQ6</accession>
    <name>A0A0F4JKQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947304.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34775">
        <property type="protein sequence ID" value="KJY34775"/>
        <property type="gene ID" value="VR44_11315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6158"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="376" mass="42162" checksum="5F9C37930CEB8148" modified="2015-06-24" version="1">MTSSAPHSPPRTRYPRQDAVPAPDTYRTRTAGIRLWDGTLLSEVVTPRHDLAARPRPFPVQRNYFHTAALEAGARWLRETVPLERDEYERLLTEDVGGFVSWVYPDAQPARLRTLIDFHHWAVWLDDVMDRRTTLETSLEACSVLESLGTVELAPFDDFFARMRGQGLHEGHAGRFLTAMRAYGASSRTEVHARDDHTCGYTTIPGYIANRRRSAAMPVYFALIAWISGVELPTHVYGHPLVVQLENACSDYALLYNDAGSFTKEYLAGRTGGTFVRLLSHELQLPVQDTLYEIADMAAAAADDLEAASDLIDTSDLPAAHREHVHRYADGLRKFTGGVNHWSNHTIRYAIGQPMTDTAPTSRTGDRHHLRTGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL08</accession>
    <name>A0A0F4JL08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947732.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33651">
        <property type="protein sequence ID" value="KJY33651"/>
        <property type="gene ID" value="VR44_13550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6971"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="44239" checksum="04D3ED706D061EDD" modified="2015-06-24" version="1">MNGLSAPAPLRRNRDFTVFWLGQALSVIGGSLSLVALPVLVLDATGSLVQMGLITVVTGATGILTGLFAGHVVDRSDRRRLMIVCDLARAVLLGAVPLVWLTAGPLVWPLYVLTVLVTALKTVFDVAYVTAVPQLVGTGELTAANSRLMGTFALGTLAGPVAAGFITAGPGGEWALGIDGATFLVSAVSLRWVTFGRHAPPADEAPAPAPASPGGRLREVFAVGFRFLWGHALLRPLTVLLTLLTFVTMGATDLLIYRVREDLRQDAATLGYVLAVSGLGVIAAALAAGRLRRVLGFGPCWLGTVGLIAVAVAGVGLSGSVPVIALLGAVFMFGITLGGITSMTLRQEVTPDALLGRVTSAFWTVHNAAGPVGAAVLTGLGARYGVPAASVAGGVLCLLILGAGLATPLRSARRPPAAAVSAAVCDARRAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLJ0</accession>
    <name>A0A0F4JLJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide sugar-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000334">
        <property type="protein sequence ID" value="KJY33831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947642.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2341"/>
    <dbReference type="EnsemblBacteria" id="KJY33831">
        <property type="protein sequence ID" value="KJY33831"/>
        <property type="gene ID" value="VR44_13115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6686"/>
    <dbReference type="eggNOG" id="COG1213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="22848" checksum="56407002141F9E74" modified="2015-06-24" version="1" fragment="single">LGNFAEVGLTEVAIVVGYRKEAVYERREALEAKYGVKITLIDNDKAEEWNNAYSLWCARDVLKQGVILANGDTVHPVSVEKTLLAARGNGQKIILALDTVKNLADEEMKVVTADGQGVRKITKLMDPADATGEYIGVTLIEPEAAEQLAEALKTTFERDPDLYYEDGYQQLVNDGFTIDVAPIGDVKWVEIDNHDDLAKGRTIACQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMR9</accession>
    <name>A0A0F4JMR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="17" type="ORF">VR44_10840</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947219.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3383"/>
    <dbReference type="EnsemblBacteria" id="KJY35119">
        <property type="protein sequence ID" value="KJY35119"/>
        <property type="gene ID" value="VR44_10840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6018"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="16">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="15">
        <location>
            <begin position="146"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="28567" checksum="551D48D4FC6F6D6B" modified="2015-06-24" version="1">MTTTADSATITAQNRSQSRLEPVHAMSDASQNPEAEATVRPARSLPGRPPGIRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALERKGFLRRDPHRPRAYEVRGSDQPSSQPTDTTGKPAASYVPLVGRIAAGGPILAEESVEDVFPLPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMLDGEATVKRFKREDGHVWLLPHNAAYQPIPGDEATILGKVVAVLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN24</accession>
    <name>A0A0F4JN24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000212">
        <property type="protein sequence ID" value="KJY35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947029.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000212.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35590">
        <property type="protein sequence ID" value="KJY35590"/>
        <property type="gene ID" value="VR44_09805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5461"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21345" checksum="D35785D82A679470" modified="2015-06-24" version="1">MTPPTLPRQASSPEAGGGRPPTPGERRSTVRRRWVTALIILLLIGVPAGYLAISAQQSRESGRDKAARVGAVKVRPDWPSKVQRSIYEVPIPLMAAHVGYLETNNWHTSRLYVQFQVTPEQLDTFLADIGTGRGALTPGVSVSDRDAQVAGWSWSPAHQWSGVTLEAEDPRPTRDVTVDFTNPAAPRVYVVSTTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN86</accession>
    <name>A0A0F4JN86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000291">
        <property type="protein sequence ID" value="KJY34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34401">
        <property type="protein sequence ID" value="KJY34401"/>
        <property type="gene ID" value="VR44_11935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6468"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9979" checksum="B28455542BAF81CA" modified="2015-06-24" version="1">MDLLRATAQEMSELCGISRAEAVARVNWHWEGLDLSGEDEIILHEDEYYWALRIYFADVLDWRPTADRSDWTPRPGPPAGSRCWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JND1</accession>
    <name>A0A0F4JND1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000229">
        <property type="protein sequence ID" value="KJY35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947128.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000229.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35344">
        <property type="protein sequence ID" value="KJY35344"/>
        <property type="gene ID" value="VR44_10355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5942"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="14265" checksum="25B7147CC97C087B" modified="2015-06-24" version="1">MHITTRRPDTLQGPAEHFTGTVWLDEIAAPESPSRLRMFSVHFAPGAHTAWHRHPHGQVLHVLEGEGLVQREGGDVAAIRAGDTVWIEPGERHWHGAAPGTFMTHLAVVEAAEDGSTVEWHEHVDHYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNK0</accession>
    <name>A0A0F4JNK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946904.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5112"/>
    <dbReference type="EnsemblBacteria" id="KJY35780">
        <property type="protein sequence ID" value="KJY35780"/>
        <property type="gene ID" value="VR44_09160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5096"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="35195" checksum="83CC6276D940D790" modified="2015-06-24" version="1">MRIAVTGSIATDHLMTFPGRFADQFVADQLHTVSLSFLVDNLDVRRGGVGPNICFGMGQLGSRPILVGAAGSDFDEYRAWLDRHGVDTASVRISEVLHTARFVCTTDADHNQIGSFYTGAMSEARQIELKAVADRVGGLDLVLIGADDPEAMLRHTEECRTRGIPFAADFSQQIARMDGDNIRTLMEGATYLFSNEYEKGLIESKSGWTDEEILAKVGTRVTTLGSKGVRIERAGEEPILVGCPEETAKVDPTGVGDAFRAGFLTGLGWGVGLERAAQLGCMLATLVIETLGTQEYTLARAHFMERFTKAYGDEAAAEVRAHLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNQ1</accession>
    <name>A0A0F4JNQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000186">
        <property type="protein sequence ID" value="KJY35982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946851.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000186.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35982">
        <property type="protein sequence ID" value="KJY35982"/>
        <property type="gene ID" value="VR44_08860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5019"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="627" mass="65912" checksum="081D4B0012D2DBD3" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPA1</accession>
    <name>A0A0F4JPA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000263">
        <property type="protein sequence ID" value="KJY34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947312.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000263.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34761">
        <property type="protein sequence ID" value="KJY34761"/>
        <property type="gene ID" value="VR44_11350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6165"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="49199" checksum="AE8172C9E8E60229" modified="2015-06-24" version="1">MTAKPYLTGHYEPVADELTATDLTVDGTLPPELTGRLIRNSHNPKPGVTPTHWFKGSGMVHGIRLREGRAEWYRNRWIQTPALDGAPYMTEHGPDLTASTAGTHVIEHAGRLLALCEANFPFQLTPDLETVGPYDFDGKLHSAMTAHPKSDPVTGELHFFGSSPFPPYLVYYVADADGHITHSAEVPGAGAALKHDFALTRNHVVFVEGTVTFDPTEHSGIPYSWQDEQPARIGVMPRGAQGTAAIRWFPIEPGNMLHVANAYEDTHGRIVLEGPTVDREGFQLSWNWWVGAPGRGSEPNTRSYNRRWTVDLTTGRVDERVIDDLAIEFPTLNEDFLGVENRYQYAVSFPDQHGFGGYGVVKYDRATGGRRIHQAGDARLPSEAVFVPAAGASREDDGYLLTVISDLKQDASQLLVLDAAGLDTIATVHLPRRVTAGIHGSWIPDTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPL8</accession>
    <name>A0A0F4JPL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000166">
        <property type="protein sequence ID" value="KJY36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36317">
        <property type="protein sequence ID" value="KJY36317"/>
        <property type="gene ID" value="VR44_08180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4386"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6497" checksum="F1A977D900DF3DD4" modified="2015-06-24" version="1">MITAHGVPIAVSSRTNEVIADWTFHSKEPKKTNAVATAAAITVAFVRVALGTMASRSRPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPQ0</accession>
    <name>A0A0F4JPQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000254">
        <property type="protein sequence ID" value="KJY34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34906">
        <property type="protein sequence ID" value="KJY34906"/>
        <property type="gene ID" value="VR44_11170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7195" checksum="884A93270B2FB586" modified="2015-06-24" version="1" fragment="single">MTDTLTAPRPVLSAAPAPRSAARWAVVGGVVAGPLFLAAGLVQGFVRDGFDFTRNAISQLALGDAGWIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQM4</accession>
    <name>A0A0F4JQM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000182">
        <property type="protein sequence ID" value="KJY36048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36048">
        <property type="protein sequence ID" value="KJY36048"/>
        <property type="gene ID" value="VR44_08770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4998"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="10837" checksum="1CFD2602400E0E54" modified="2015-06-24" version="1" fragment="single">VVCVWQPPLFLLNDEEVALKAQRFLLGEATAGLADAYPDVHVTHEVLTGHPVEELARTAEHALALVVGRRGRGGYTGMRLGSVTHGLLHRAHCPVITVPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQP4</accession>
    <name>A0A0F4JQP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946826.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36068">
        <property type="protein sequence ID" value="KJY36068"/>
        <property type="gene ID" value="VR44_08755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4995"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23272" checksum="A23433C66F37B0DA" modified="2015-06-24" version="1">MNHIKVADLMTDEVVSVPPGTAVKEVAKTLAQHDISGVPVLDDEDRVVGVVSQTDVLALARSGPHARGTPQGVPPTAGEIMSAPAVTVRAEETAADAARLMIRRGVERLPVVDVEDRLVGIVTRRDLLRMFLRPDAEIRRRVEDILTDVLDVPAGDVDVHVVDGIVTLNGRVHRRSQLRSLLGLVERVEGVVAVAPRVTAHADDTAATAGDGRGALPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQS3</accession>
    <name>A0A0F4JQS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946804.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36098">
        <property type="protein sequence ID" value="KJY36098"/>
        <property type="gene ID" value="VR44_08615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4865"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="509" mass="53343" checksum="84C7F4A13C3D2DE6" modified="2015-06-24" version="1">MTTALDQPKEPEATPSPPAAPGDDHGFLGHPGGLATLSGLEVWERFSFLGMQAILVLYFADAVAHGGLGMDPATAASVAAAYGTMVYLVSVAGGWLADRILGSYRAVLWGGVLIACGHYAMAVPAPATTWTGLGLISAGTGLLKPNVASMVGRLYRTDDERRDAGFALYYMAINIGAFAGPLVAGWLGEHQGWHWGFSAAAAGMTAGLAQYVLGRRRLPGRDGSATHALPPAARRTAVRRIAAAGLALAALATLLAAIGWLTMPRFVDLLTLVSVIAPVVYFTVMFRSPRVTAAERGRLRPYVVLFLASVAFNFILFQAYSTMMLLASTNARTEILGFHFPAGWYASALGAFEVALAPVVAGLWVRMGRRQPHASLKIAIGVVLGGLSFLLMVLPTSGHGADEGFRMAAWWIVGSYLLLGLGDVLLETSGMSATTRLAPSAYAGQTMALWFLSLALANGIQAQVVKAYGHVSTPVYFGVNGAVAVAAGLAVIAAAPWLRRTMTLPTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRJ2</accession>
    <name>A0A0F4JRJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000164">
        <property type="protein sequence ID" value="KJY36393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36393">
        <property type="protein sequence ID" value="KJY36393"/>
        <property type="gene ID" value="VR44_08160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4381"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="12901" checksum="DDAF001D65764C2A" modified="2015-06-24" version="1">MVLKSGFPAYGVTGDPNAATDCCEPLVLGPLFGAHGAAPADLSVAFVSRAAAESGSFGAPYDALGTRRRRVAVRGTRGIGPGSMIGNARLGEVDVDPRSGLVSLDGQPLRSEPADRVSLNRLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRZ2</accession>
    <name>A0A0F4JRZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000148">
        <property type="protein sequence ID" value="KJY36604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36604">
        <property type="protein sequence ID" value="KJY36604"/>
        <property type="gene ID" value="VR44_07605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3999"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17354" checksum="59293E91A099F302" modified="2015-06-24" version="1">MSEIADTPVPVPAAGPAAVSAPDVQTVHEAYSFACMKCGFGWEQSYAIEHHTDGKGQPFIMYKVNGERVPSPLSNPTCLNCGGHVVRIMRAGTVSQVNATIDRLYHHRIAPGIAGPVPAGENPPRAPRQRRPSHDSPGPVAVNEPGRRPGPLSRLLGRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSE7</accession>
    <name>A0A0F4JSE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37090">
        <property type="protein sequence ID" value="KJY37090"/>
        <property type="gene ID" value="VR44_06495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8324" checksum="451A92CFA9B596E8" modified="2015-06-24" version="1">MDMTTPEARATYAELLRREEAVKELPRVVDFSRPQIPTGPPPRWFETPGPAAFHVVRKASSPPPAWSGSLPDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSF1</accession>
    <name>A0A0F4JSF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37095">
        <property type="protein sequence ID" value="KJY37095"/>
        <property type="gene ID" value="VR44_06520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="14013" checksum="E50974CE132E01D2" modified="2015-06-24" version="1">MSSPSDLAAEFLPEPTKPLAVALYEAGQFGLDPDGLRFHCFPPWGDAGCFASASRFFTMVRVSTVVKDDGRAARSSPSVIQAAAAEIWSSSATAQSTCHHLPRTLLMACPALGTLWQPPQGVPEPSASLGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSQ8</accession>
    <name>A0A0F4JSQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000106">
        <property type="protein sequence ID" value="KJY37407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37407">
        <property type="protein sequence ID" value="KJY37407"/>
        <property type="gene ID" value="VR44_05725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1960"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="37269" checksum="8AFC71B9B907FE6A" modified="2015-06-24" version="1">MGAPAAADGGTPPGRVEFPTRCLPAAAGPTTARIEVDDPSPGVGDTVTVTYRLDRTPPGPGPQGAFPAPTGRVLLGGAQTGEVPVSAAPGADPGGAAVTGAEAASPGSAGAGGSGVVMKGSFVVTAPGELTLTPGGYALPGGVCAVAGPSAPVARRLTVAPLPVMNLRGVALGTSYGEPGARVRVTGAGFTPGAAVTVAGRAGAAGTADRAVATADRSGAFGVELVVADRGTTGVVAYEGTAWSPERGARPQAYAVVEPTAPAGGGLTMTQAGAAITLGPVGYGGAGGGAGRIGTVTVVDARGAGAARWTLRGKLTDFTGPDGARIPGASLSWIPSCGGGGCVPGPPGAVGPEGAVLASGEGGSSTVDAAVTLRVPAYTPPGAYRAALTLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTM9</accession>
    <name>A0A0F4JTM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946150.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene157"/>
    <dbReference type="EnsemblBacteria" id="KJY37722">
        <property type="protein sequence ID" value="KJY37722"/>
        <property type="gene ID" value="VR44_05095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1334"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="369" mass="39994" checksum="9391C1D924152D95" modified="2015-06-24" version="1">MGLTSNAVLVLAIIAGVALFAVTVWLWPKLSGRTWRSVLGRVGLLLATQLALFSAVGLAANKSFLFYGSWADLFGQQTSIGKVVDHSMSSKDIKVLDKQKLDVPGGGQPQVGGQILKVAITGEKSKITSPGYVWLPPEYFQPQHKDKNFPASIVLTGYPGTAENLIKGLNYPMTAFKQAKQGKMKPMILVMLRPTIAPPRDTECVDIPGGPQTETFFAQDLPQAIQGTFRVGKKPQNMGFIGNSTGGYCALKIAAHHPQTFGAAAGLSAYYKAADDPTTGDLFHGDEKLKKAADVLWSVENKKPTGTSFLVTTSEKGEDNLNDTKKFIKLVKGPDRVSSIILDSGGHNFNTWRREIPPMLVWMSSRMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUJ1</accession>
    <name>A0A0F4JUJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_07555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946611.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36646">
        <property type="protein sequence ID" value="KJY36646"/>
        <property type="gene ID" value="VR44_07555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3988"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470879" evidence="8">
        <location>
            <begin position="38"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="199"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="736" mass="76580" checksum="3E5BF285323C6E63" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVC9</accession>
    <name>A0A0F4JVC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_04220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945992.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38110">
        <property type="protein sequence ID" value="KJY38110"/>
        <property type="gene ID" value="VR44_04220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.134"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471087" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="8">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="179"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="352"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="534" mass="57041" checksum="B6ACF88DCCBA758C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW04</accession>
    <name>A0A0F4JW04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945852.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38542">
        <property type="protein sequence ID" value="KJY38542"/>
        <property type="gene ID" value="VR44_03420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7901"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470941" evidence="1">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19340" checksum="E7C6A72E67970BE1" modified="2015-06-24" version="1">MNKKLAAAVSCGAVLMLVLSGCGGDDDGDKKADAWAKKVCDKWEPELTKIKGTNDDLKRVASQSSKPEEVQKTDSAAFQTLSESYKSMAASLTAAGEAPVKDGKTAQDSVVKSYGEISKGYTDLKTKIDALDPKDQAKFADGLQQVAGGLTEVAANETASKEKLNSTGLKVIYSQKGCQVSAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW91</accession>
    <name>A0A0F4JW91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945789.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38637">
        <property type="protein sequence ID" value="KJY38637"/>
        <property type="gene ID" value="VR44_03080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7831"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="22637" checksum="07F5A9F67BE9F85A" modified="2015-06-24" version="1">MNTFATTAAVSTVLDIPAGRVRLVAADRADAAVEVRPMDAAKGRDVKAAEETTVEFRDGVLRIAAAPGRSRVMGNSGQVEVTVQLPAGSHVTATVAAAEFRTAGPLGELVFEGAQAEVTVDEATSARLTLQAGDVVLGRLNGPAEISTQKGDITIAEATKGDVILTTQHGTISVGAAPGVSATLDAGTSYGRIHNALNNTDGAAAALTIRATTSYGDITARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWH9</accession>
    <name>A0A0F4JWH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945757.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4895"/>
    <dbReference type="EnsemblBacteria" id="KJY38727">
        <property type="protein sequence ID" value="KJY38727"/>
        <property type="gene ID" value="VR44_02930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7318"/>
    <dbReference type="eggNOG" id="ENOG502ZWGX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="18077" checksum="CA8C430FF1BED26C" modified="2015-06-24" version="1">MTTRGVLYVHSAPRALCPHVEWAVAGVLGVRVNLDWIRQPASPGTWRAEFSWQAEAGTASKLASALRGWHLLRFEVTAEPCPTAEGERYSSTPDLGIFHAVTGMHGDILVPEDRLRAALARSARGETDLEAEIAKLLGKPWDDELEPFRYAGEGAPVRWLHQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWM7</accession>
    <name>A0A0F4JWM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_03380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945846.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38535">
        <property type="protein sequence ID" value="KJY38535"/>
        <property type="gene ID" value="VR44_03380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7893"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="126"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="29443" checksum="52923049F8589EE6" modified="2015-06-24" version="1">MNAGALGSVPVFAGVLCAGAAAWGLAGGDGVSRRARLVLAGGVPVVPRGPSPGWRLVAAVRVRAAWWREGAAVGAGLLVAVLGGSLIPLVLAAASVPLLRGWLRARWRERAREARAAGVVELCGAVVGELRAGAQPGRALTAAIRRTAAGPGGPGPAEAAVLAAAAFGGDVAGALQEAAREPGAEGLAAMAACWRVSVDGGAGLAAGLDRLEGALRAERDRKESLRAQLAGARSTTLVLALLPLVGLLMGTALGADPLEVLLHSPVGWGCLVAGGVLEVLGLLWCRRIVRTGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXV1</accession>
    <name>A0A0F4JXV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_03260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945823.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38563">
        <property type="protein sequence ID" value="KJY38563"/>
        <property type="gene ID" value="VR44_03260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7867"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="77"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="362"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY38563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="775" mass="81234" checksum="A5FE434692A2DB51" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYA8</accession>
    <name>A0A0F4JYA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945753.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38723">
        <property type="protein sequence ID" value="KJY38723"/>
        <property type="gene ID" value="VR44_02905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7313"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471356" evidence="1">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24536" checksum="6D5FB768FEFBC042" modified="2015-06-24" version="1">MKIAAAQLTCIPADVTANAAHATALAARARNEGAELVVFPELTLTGYELEALTADPSLWMSGADDPRLDGLRSAGTAVAVNVALRTPHPLPAIATLVYDADGAHLTTYAKQHLYQHEQGAFTPGTTDGRFELGGIRFSLGVCFDNHFPDLPARGAADGCRVHLAGSLYGTGGGITERATVYPAMAKEHGLYVVLANHVGPAGPWTGCGGAAVWAPDGTLLAEADAHTQTVTTADVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYE1</accession>
    <name>A0A0F4JYE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type VII secretion protein EccE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000060_gene2697"/>
    <dbReference type="EnsemblBacteria" id="KJY37991">
        <property type="protein sequence ID" value="KJY37991"/>
        <property type="gene ID" value="VR44_04530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.715"/>
    <dbReference type="eggNOG" id="ENOG50331Q0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="41209" checksum="67E0CB39DDA1BB47" modified="2015-06-24" version="1">MQQFVLLQLAAAALLVAWVVEPLLLVPAGAGALVLVLLALVRRHQRSLPEWIGGVLALRARRRRAASATVPAGTEPGLAPLVEADPALRTTAFGGRDRRPVGLVGDGTFLTAVVQVDMDATALRPERTARPLPLSAVRDVLEVDGIRLESAQLVQHTQPAPAPHLPAQSMAARNYAPLQARTGTPAVRLTWIALKLDPELCPEAVAARGGGLVGAQRCVVRAADQLVSRLTGAGFRATVLTEQELTGALATSSCANPMAITQAGRSGSTGRRTEETPRTWRCDDRRHTTYWIARWPQLGGAGAALPQFAALLTSLPALATNFSLTMAPAGRQGVTLTGHVRVTGRSDEELVAARRELERTARGVRTGLVRLDREQVPGLLASLPLGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYW4</accession>
    <name>A0A0F4JYW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39340">
        <property type="protein sequence ID" value="KJY39340"/>
        <property type="gene ID" value="VR44_01855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5775"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="27137" checksum="A2E994306990FDF0" modified="2015-06-24" version="1">MGGPVRVLALHGLAGTDTVWHDCARIAAPEVEFWSALMPWGAAGKETWSHRGDPAAWIGQALDAVPGGVDVLIAHSFSTGLALETLAGMDRAVRPGAAVVVAPFHRRSPEDFAWHTASHYLNSYHGFLDECLRIGSRRPLDDGVRRDMALRVRDRVGAYGFLRFLDTYLRSPFLDTAALDLPVLVVAGDGDPFAPLDDARGLAAALPDARLRVFQDCGHLPMAEQPKGFAAAVDDLIRETFPAHSERYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZU9</accession>
    <name>A0A0F4JZU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945592.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39223">
        <property type="protein sequence ID" value="KJY39223"/>
        <property type="gene ID" value="VR44_01990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="17854" checksum="0C31F3B2642D12A9" modified="2015-06-24" version="1">MTRPTPPNPYDFLPELPELKVVSDDVRDGDRLSEAQLASGGNLSPALSWEPGPEGTASYAVTCFDPDAPTPGGVWHWILADIPPHVHGLPAGGEPGTGRELLNDLGSLGFVGAAPPAGDREHRYIFAVHALGVDGLPVDQQTPAALVGFHLTVNSLARGAITGLARTAGQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K054</accession>
    <name>A0A0F4K054_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_01815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945548.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39318">
        <property type="protein sequence ID" value="KJY39318"/>
        <property type="gene ID" value="VR44_01815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5767"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="42816" checksum="5E9E51098988A0C5" modified="2015-06-24" version="1">MSITEAAPAAPGIAPGEFGRLRAEVAAYVAGPAEQWAHRIESTGTVPEELWTELRERGYLSLAAPREYGGRGLSFPQWMDLMELFSRCHGSLRMVVHVVNGTWRAMDQFATPDQRERFVLPSVAGRLKVAFTLTEPDAGSGADIRSSVVREGDTYYLTGTKHLITFGVRCDYWLLAARLAGSTGHEGTVALMVPRDAAGVTVEDTSQTMGVTGTDHARLTFDRTPVPVANRLGGEGDGLAVALGGFLTPSRISVAMSCVGLARRAQELALEYARNRVTFGRPLTSRQALQFMLAENEADIEAAKQLTLHAARCWEAGAEDAAMLSSMAKLTAVDMLGRVTDKALQVHGGSGYWKSSPIERVYRDARAQRFEEGTNEIQKAVVFRELLNRTGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0F3</accession>
    <name>A0A0F4K0F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945433.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4710"/>
    <dbReference type="EnsemblBacteria" id="KJY39584">
        <property type="protein sequence ID" value="KJY39584"/>
        <property type="gene ID" value="VR44_01170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2948"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="33522" checksum="AD5EF573C21AFBBA" modified="2015-06-24" version="1">MAGDTDTGERAAHGSARLSAELRGFREVQRLAYECAETVAAQLRPGVTEREAARMQREWLRERGVRDWFHLPFAWFGDRTAFTGFRIPLQFFPTNRKLEPGMPFILDMAPVYRGYAADIGYSGSLGLNPVQDRLMSDLRPHRALILEQVRERRPLREIYENVERLMTRQGYANRHRAYPFGVIAHKIDRVKERRWSPTAFGFGTQSLKGLASDALHGHREGWSPLWSPYHFSDHPPQPGLWAVEPHLGFRGTGAKFEEILVVTDSRDPEESAFWLDDDLPHVRRWTEEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K325</accession>
    <name>A0A0F4K325_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_01345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945464.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39556">
        <property type="protein sequence ID" value="KJY39556"/>
        <property type="gene ID" value="VR44_01345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2985"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13488" checksum="6F91061F029A04FF" modified="2015-06-24" version="1">MNVGDALPPLEIPVTRTLIVAGAIASRDYQDVHHDAELAREKGSPDIFMNILTTNGLVGRYITDHLGPHAVLRKVAIRLGAPNYPGDTMTLTGTVTALDGDTAEIQVTGANRLGHHVTGTVTVTLGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I291</accession>
    <name>A0A0F4I291_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001801">
        <property type="protein sequence ID" value="KJY16027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16027">
        <property type="protein sequence ID" value="KJY16027"/>
        <property type="gene ID" value="VR44_40640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="10782" checksum="973386929606F608" modified="2015-06-24" version="1" fragment="single">GPAGPDQAAAEDGSDPEAGAEDSSGGSEAGPEPEAGAESGPGEAGAGSGEGAGAAGLSEAQAELAAQRVERERIARRKAEREHPVEAGGKLSGRAADLLAAVRAVESGAKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I694</accession>
    <name>A0A0F4I694_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001665">
        <property type="protein sequence ID" value="KJY17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17505">
        <property type="protein sequence ID" value="KJY17505"/>
        <property type="gene ID" value="VR44_39945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9162" checksum="4E0EB916FCDC634A" modified="2015-06-24" version="1" fragment="single">PQQRLLLETAWEAFERAGLDPTSLRGTGTGVFIGSGYQDYASRLLSVPQDLEGYIGTGSSASVVSGRIAYSFGLEGPALTVDTACSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I942</accession>
    <name>A0A0F4I942_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001686">
        <property type="protein sequence ID" value="KJY17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952629.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001686.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17211">
        <property type="protein sequence ID" value="KJY17211"/>
        <property type="gene ID" value="VR44_40105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6393"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="20762" checksum="10D8EB005D132CE5" modified="2015-06-24" version="1">MHRALIVVDVQNDFCEGGSLAVTGGADVAAAITELIGNATAGYRHVVATRDHHIDPGPHFARPPAEPDYENSWPAHCVAGTEGVGFHPNFAPAVASGAVAAVFDKGAYEAAYSGFEGTDENGAGLAQWLRERQVAEVDVVGIATDHCVRATALDAAREGFATRVLLDLTAAVAPHTTEKALEDLRAAGVTLVGRVGGQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB26</accession>
    <name>A0A0F4IB26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001579">
        <property type="protein sequence ID" value="KJY18874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952493.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001579.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18874">
        <property type="protein sequence ID" value="KJY18874"/>
        <property type="gene ID" value="VR44_39345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5671"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="30786" checksum="C631419DF1AD7CA8" modified="2015-06-24" version="1">MAEGRARTVGTAVVVRTERLTPHMVRLVLGGDGLAGFGAGAYTDHYVKLLFEPEGVRYAEPWDLDVIRATHHREAWPRQRAYTVRAWDPAKLELTLDFVVHGDEGLAGPWAARVQPGELVHFLGPGGCYAPDPAADWHLLAGDESALPAIAASMERMPRGARVHAFVEIEGPADEQDIATPDGITPVWLHRGDRPVGAALLEAVTGLDFPSADVHAFVHGEAGFVKELRRHLRLERGIARERLSISGYWRHGETDEGWRAIKRDWNATVEAEQDVPTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEX1</accession>
    <name>A0A0F4IEX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001515">
        <property type="protein sequence ID" value="KJY20229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20229">
        <property type="protein sequence ID" value="KJY20229"/>
        <property type="gene ID" value="VR44_38800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5473"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9365" checksum="546D729E5FA646EA" modified="2015-06-24" version="1" fragment="single">SFVRVRMFGPGHPWHAMDDYTGDLAHIGLAILDRDSGEWAPEFEEALAHPVGDLLVMDRVVLEPAWRGFGLGPALAGAAIRRLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFA8</accession>
    <name>A0A0F4IFA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001556">
        <property type="protein sequence ID" value="KJY19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19346">
        <property type="protein sequence ID" value="KJY19346"/>
        <property type="gene ID" value="VR44_39155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5595"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="28351" checksum="5A11ACC48E0CD618" modified="2015-06-24" version="1" fragment="single">MNDPHPAPDHEPDHIPGEPPALSATRLGREFPGRRALRGCDVELPPGRVTALVGPNGAGKSTLLQLAAGLLRPTSGRIRVFGHAPGTAEARRRTAFLGQDKPLHARFTVAETLRLGRELNPGQWDQAAAERLVRGGDIPFHARVGSLSGGSRTRVALALVLGKRADLMLLDEPLADLDPLARHEVMGLLMAEAAERGTSIVMSSHVLAELEDACDHVLLLADGTVRLAGDTQELRDTHTWLTGRADPMEPDGLPRDFDRGTVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILA2</accession>
    <name>A0A0F4ILA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine/betaine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_37925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001422">
        <property type="protein sequence ID" value="KJY22429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22429">
        <property type="protein sequence ID" value="KJY22429"/>
        <property type="gene ID" value="VR44_37925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY22429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="562" mass="59446" checksum="F39F74199A9A55B5" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM88</accession>
    <name>A0A0F4IM88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001401">
        <property type="protein sequence ID" value="KJY23127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952183.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001401.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000033_gene6766"/>
    <dbReference type="EnsemblBacteria" id="KJY23127">
        <property type="protein sequence ID" value="KJY23127"/>
        <property type="gene ID" value="VR44_37700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5046"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="14209" checksum="B4B2DF29DC45323F" modified="2015-06-24" version="1">MAIGPVRTEYAPDPDGDPDPGEIVWTWVPFEENDGRGKDRPVLVVAREAGGSTLLAVQLSSKRHDADREWVPIGSGPWDSAGRESWVDVDRVLRVHEAGMRREACALDRSRFGLVVDRLRERYGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IN36</accession>
    <name>A0A0F4IN36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_38075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001434">
        <property type="protein sequence ID" value="KJY22036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952256.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001434.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5214"/>
    <dbReference type="EnsemblBacteria" id="KJY22036">
        <property type="protein sequence ID" value="KJY22036"/>
        <property type="gene ID" value="VR44_38075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5218"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="33"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY22036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="26239" checksum="3CB7C4F19C439EE9" modified="2015-06-24" version="1">MTTAAAPAAVLAPRARLFPALAAVYRAQLSRARVARIPLLFVATFQSVGIMVLMRGVVDGGSEARAVVAGSSVLVVAFVALNLLAQYFGQLRASGGLDHYATLPVPPASVVLGAAAAYASFTLPGTLVTAVFGCVLFGLPMGGLWILAAVVPLAGAALAGLGAALGLLAPRQELATLAGQLGMSAALLLGVLPAERMPQVVVWARDLLPSTYGVEAFARTFAPHPDWAAVAADLGVCAAVGVLSLAVATWAYRRASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IN40</accession>
    <name>A0A0F4IN40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CobG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001433">
        <property type="protein sequence ID" value="KJY22041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952253.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001433.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22041">
        <property type="protein sequence ID" value="KJY22041"/>
        <property type="gene ID" value="VR44_38060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5178"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="44285" checksum="E8B7ABCB24550592" modified="2015-06-24" version="1">MLAAMPPQPPSAASRDEPVIRDRGDACPSALRLHAADDGYLARVRVPGGLLTVPQAAALGLAADRFGDGHLELTSRGNVQLRGLADGCGAGLAELLGGAGLLPAPSHERVRNIVATPLGGSLVVDWVRELDRLLCASTRAAALSGRFLFALDDGRGDVAALDPDVTVLSVGSGGSGAAGRAEPRAVDAVEVGVADAPRAALLAAEYFLDSADASGSRAWRVAELGSGDEQGLDAREFALRLRARGIVARYVPEVAWPYAEPPRPWGEYGAGLCVLPPLGRLSSAQWRVLAEAAGGADGELRLTPWRSVILPRAAAGAAGRVEAAGLAVRPGSPWLSVTACTGRPGCAKSLADVRADARAVVAESAGGLPVHWSGCARRCGHPRGTAWVDLVATPDGYELDGGPVPHADLAAALTAARTTPTTTEAATEAAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IN89</accession>
    <name>A0A0F4IN89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001392">
        <property type="protein sequence ID" value="KJY23490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952164.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001392.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23490">
        <property type="protein sequence ID" value="KJY23490"/>
        <property type="gene ID" value="VR44_37605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5026"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470101" evidence="1">
        <location>
            <begin position="28"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="44"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="32663" checksum="88857FF4CE28F47A" modified="2015-06-24" version="1">MYVRSAAAAAAAFLGFTLTLLGGTACAAAPGPGSASGATGLLGPTVYAHRGASAYAPENTLEAIDLAMRLGFDWVENDVQRTKDGELVVIHDDTLARTTDVEQVFPDRKPWRVKDFTAAEIARLDAGSWFSPRFAGARVPTLREYMERVQDNRQRLLLEIKKPELYPGIEEQTLKVLEETGWLDAGHVARRLVVQSFSAESVRIVHGLRPDLVTAFLGTPTVADLPRYAEFTDRINPWHTTISADWVTAVHGLRGAHGKTMEVDTWIVDDAPTARKVREMGVDGIITNAPDVVRGAVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INK6</accession>
    <name>A0A0F4INK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_38025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001430">
        <property type="protein sequence ID" value="KJY22211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952246.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001430.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3750"/>
    <dbReference type="EnsemblBacteria" id="KJY22211">
        <property type="protein sequence ID" value="KJY22211"/>
        <property type="gene ID" value="VR44_38025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY22211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="17350" checksum="1C1DC5A9085624AC" modified="2015-06-24" version="1" fragment="single">MTVYFIGAGPGAADLITVRGARTLAAAPVCLYAGSLVPRELLDECPEGARLVDTSQLNLDQIIAECVRAHEAGLDVARLHSGDPSIFSAVAEQMRRLDAAGIPYEVVPGVPAFAAAAASLKRELTVPTVGQTVILTRIAQQATPMPPGEDLATLGRSGALLVLHLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INV4</accession>
    <name>A0A0F4INV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001384">
        <property type="protein sequence ID" value="KJY23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23707">
        <property type="protein sequence ID" value="KJY23707"/>
        <property type="gene ID" value="VR44_37535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4929"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="29072" checksum="61118567A189B563" modified="2015-06-24" version="1">MHRRRRVRGSRFYNLVIEDCTGTTDSTTQPNIWLRNASSATEGAWGHSKDNINQIHFIGCRLEAFGTGALWIGQGAVTTNNPNGVYITDCKFETSRMQGGPHLKTDAGCKHVYATNIYCYAGDFAAGTPATARNIISWAASASALENVVIANRDKATVNAGVALYSGPGSTAVLRNVVGLYATAPTGTHIYYEQSSTGDFRVENSYGSLGAQATGTIPVKNAPNPPLRLVPGPVSDASFTRQPLDGTLAVDSANKRLYVRVGGQWLWSALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP95</accession>
    <name>A0A0F4IP95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001420">
        <property type="protein sequence ID" value="KJY22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22436">
        <property type="protein sequence ID" value="KJY22436"/>
        <property type="gene ID" value="VR44_37910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16334" checksum="D30A1C3D02378FBE" modified="2015-06-24" version="1" fragment="single">LWGQILRSTVAHAEIVSIDTAEALTVPGVHAVLTYEDLPAPVKYYGMEFRDTPVLAHRKVRHHGEPVAVVAADHPETARRAAAKIRVEYRELPLVTDEASATAPDAVLVHEDREDHHASHVPHPNIVHRQPIVRGDADAAALRAEVIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPQ9</accession>
    <name>A0A0F4IPQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHASE3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001316">
        <property type="protein sequence ID" value="KJY23987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23987">
        <property type="protein sequence ID" value="KJY23987"/>
        <property type="gene ID" value="VR44_36660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4641"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE3" evidence="2">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21944" checksum="A32849BC9866E75C" modified="2015-06-24" version="1" fragment="single">MRAWLITVLVVLALTVVGTGALGAALLSRTTTAGNRLVDEILPAQRDALRLETAVLDQETGVRGYLLAHEPALLEPYERGRADETEAARRLATVLADDEGVREDLAAVQRAARTWREEFAAPAITSVENGTTPPSAQAGKDRFDEVRRRVAAQQARLDRLQDDARSTFGAARTQRDRVLLAIVVAFLLAGVALAVLLDVGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQM9</accession>
    <name>A0A0F4IQM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001321">
        <property type="protein sequence ID" value="KJY23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23964">
        <property type="protein sequence ID" value="KJY23964"/>
        <property type="gene ID" value="VR44_36715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="514" mass="53803" checksum="71EBC50F83017116" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR47</accession>
    <name>A0A0F4IR47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001218">
        <property type="protein sequence ID" value="KJY24495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951716.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24495">
        <property type="protein sequence ID" value="KJY24495"/>
        <property type="gene ID" value="VR44_35195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4119"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="224"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="441" mass="45942" checksum="058976D88FC4EEF4" modified="2015-06-24" version="1">MSNSRLSSVLPDLSPWRSSRDFRLLFFQGTVTFFGSFMAMIALPLQIKHLTDSPLAVGAMGAVELVPLVVCGLYGGALADAVDRRRLILLTEAGLGVLALVLLVNALLPEPMLWPLYVVAAGVSALSGLQRPALDSLMARIVPHDQLTAAAALNALRYQSGAIAGPALAGVVVAYAGYASAYAVTVAAFVVSVALCARLRPAPPAGGGERPSLRSIADGARYAWSRPVLLGTYAVDLAAMFFAFPNTIFPFLADELDAEWALGLMYAAGAVGSLVLGLTSGWVSRVRRHGLLVVFGAAGWGLAIAAAGWFSNVWLVLVCLAAAGAGDMLSALGRSTIWNQTIPEELRGRLAGIEVLSYIEVLSYSVGPQLGQVRAGTMAGWTGTRPAFWSGGLACVASVALLAALLPKLISYHADTDEDALRRRAAREGSAPEADPAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRE4</accession>
    <name>A0A0F4IRE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_34980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001204">
        <property type="protein sequence ID" value="KJY24562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24562">
        <property type="protein sequence ID" value="KJY24562"/>
        <property type="gene ID" value="VR44_34980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4045"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10948" checksum="046469B87ED6F7DC" modified="2015-06-24" version="1" fragment="single">IESLKEATRRAFASHASLSAGEQNGVINRLAIVSVVFLPLSFLTGFFGMNFTFLTDSMESREEFWLLAVGLQLLVLAVCLYVLHRTRVWRRLREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRI2</accession>
    <name>A0A0F4IRI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001256">
        <property type="protein sequence ID" value="KJY24279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951835.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001256.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24279">
        <property type="protein sequence ID" value="KJY24279"/>
        <property type="gene ID" value="VR44_35835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4323"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="33624" checksum="A4AF696BF78CBC20" modified="2015-06-24" version="1">MQKDFGDPAVTRIREAAEAADWAGVRDGLTAHPEAADRSWLLWAVGDTAGVERWIHDAVEAEPDPALPLLVAGARYISWGWEARTGARAADVSREQFEVFHERLRQAEEWLYRAAELEPSWVSPWHFLQVSGRGLQVGPVVARRRFEAVVRRAPFHLRAHQQQLQQVCKKWGGSHEEMHAFARGAMLAAPQGSPLGQLVALAHIEHWLSLDDGPDGEYMRRPETAASLLEAAERSVLHPDAEPGSGLVQVCNSFALAFSLAGAKEPARRCFELTRDTVTEFPWNYVDADPVAAYSRHRSSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRI6</accession>
    <name>A0A0F4IRI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001191">
        <property type="protein sequence ID" value="KJY24630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24630">
        <property type="protein sequence ID" value="KJY24630"/>
        <property type="gene ID" value="VR44_34745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4017"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19354" checksum="41E1F010B1E6965C" modified="2015-06-24" version="1" fragment="single">GLLWVADHADELGIDSERIVVTGFSAGGALSAALALTVRDKGGPRLLGQLLMAPLLDDRNDSASALQMDDVELFDRSRNGFAWSSLLGDARGAADVPQYAAPARATDLAGLPPTFLDVGSAECLRDEVLAYADRIWQAGGEAELHVWPGGIHGFDRKAPEARISKAAVAARRNWLEHLLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK3</accession>
    <name>A0A0F4IRK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001193">
        <property type="protein sequence ID" value="KJY24622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951643.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001193.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24622">
        <property type="protein sequence ID" value="KJY24622"/>
        <property type="gene ID" value="VR44_34815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4034"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="18609" checksum="215D2284155C4E18" modified="2015-06-24" version="1">MPDDVGGKPFPDDGEPDDDRGGADQDFASVVFDEAFVRNARIHEPSAAERQRAADLARAEAEAARVAGGWAGEDDHGHPDGYPYEDHAWEAGSYGYAEGPYGAYGGSLRPYRGRAGWLRPVAWVLAVVMGLGMVALAFSAVYRSASGDADPAPAPASTPLGEVTGVGAFTYPVVRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRX0</accession>
    <name>A0A0F4IRX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001231">
        <property type="protein sequence ID" value="KJY24414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266374.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001231.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5707"/>
    <dbReference type="EnsemblBacteria" id="KJY24414">
        <property type="protein sequence ID" value="KJY24414"/>
        <property type="gene ID" value="VR44_35430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4200"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22990" checksum="8D95FFC5EA7837AD" modified="2015-06-24" version="1">MTAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKLDLYLALLDQHCENLLQAVRGALESTSDNKLRVAATMDAYFAYVEDEGGAFRLVFESDLTNEPAVRERVDRVSLQCAEAISDVIAEDTGLSKDESMLLAVGLGGVSQVVARYWLSSESPVARDTAVGLLTSLAWRGIAGFPLHGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS57</accession>
    <name>A0A0F4IS57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="8" type="ORF">VR44_34160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001158">
        <property type="protein sequence ID" value="KJY24855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001158.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7589"/>
    <dbReference type="EnsemblBacteria" id="KJY24855">
        <property type="protein sequence ID" value="KJY24855"/>
        <property type="gene ID" value="VR44_34160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3800"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="280"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="501" mass="54599" checksum="A3A3387EA4E346AE" modified="2015-06-24" version="1">MTSSSSPSQDPRDAQDVRDPQRFTESLRADALMEEDVAWSHEIDGDRDGDQFDRSERAALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTVSDAENSLAELAALAETAGALVLDGVIQRRDKPDPATFIGSGKARELRDIVLESGADTVVCDGELSPGQLIALEDVVKVKVVDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGGGGGMATRGPGETKIETDRRRIREKMAKMRREIAEMKTGRDIKRQERRRNKVPSVAIAGYTNAGKSSLLNRLTGAGVLVENALFATLDPTVRRAETPSGRIYTLADTVGFVRHLPHHLVEAFRSTMEEVGDSDLILHIVDGSHPAPEEQLAAVREVIREVGAVNVPEIVVINKADAADPLVLQRLLRIERHSIAVSARTGQGIGELLALIDSELPRPAVEVEALVPYTRGGLVARAHAEGEVISEEHTPEGTLLKARVHQELAAELAPYVPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT33</accession>
    <name>A0A0F4IT33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">VR44_34820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01001193">
        <property type="protein sequence ID" value="KJY24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951644.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001193.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2570"/>
    <dbReference type="EnsemblBacteria" id="KJY24623">
        <property type="protein sequence ID" value="KJY24623"/>
        <property type="gene ID" value="VR44_34820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4035"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="44255" checksum="9B0BCDD2ABFD116B" modified="2015-06-24" version="1">MTSLDDAPATSPVLATAAAARTAAAAIAPLPRSAKDTALLAIADALTARTDEIVAANAEDIDRARAAGTSETVIDRLTLTPERVAAIASDVRDVAALPDPVGEVVRGSTLPNGIDLRQIRVPLGVVGIIYEARPNVTVDAAALCLKAGNAVLLRGSSSAYASNTALVAILRDAIASTGLPADAIQLVPGESRDSVRELMRARGLVDVLIPRGGASLIKTVVEESTVPVIETGTGNCHVYVDAQADLDMAVDILINSKAQRPSVCNAAETLLVHRDIADAFLPRALDALADAGVTVHGDARVLAAAEESKATALPATDEDWAAEYLSYDIAAAVVDSLDEAVAHIRRWTSGHTEAIVTTSQAAARRFTQLVDSTTVAVNASTRFTDGGQFGFGAEIGISTQKLHARGPMGLPELTSTKYIVTGDGHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW3</accession>
    <name>A0A0F4ITW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001073">
        <property type="protein sequence ID" value="KJY25437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25437">
        <property type="protein sequence ID" value="KJY25437"/>
        <property type="gene ID" value="VR44_32475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6646" checksum="552BEB217E1A13DE" modified="2015-06-24" version="1" fragment="single">LLCWEPAGIPRLVHALGAHRTLGLPAAWPDRSDLVWTLTRSRGNWTFRELSQRLLPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITZ2</accession>
    <name>A0A0F4ITZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951381.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25119">
        <property type="protein sequence ID" value="KJY25119"/>
        <property type="gene ID" value="VR44_33360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3549"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16707" checksum="38576D8901C4D88F" modified="2015-06-24" version="1">MRRNITTEITIDATPEEVWAVLTDLPRYCVWNPFIRQAGGEVAPGERLRLTMYAESGKPTTFHPAVRVCVPAAELRWTGHFLVRGLFDGEHFFRLAEGPGRTTRLEHGERFRGLLVPFLGKLLEGTARNFTLMNEALRARVEAARATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU78</accession>
    <name>A0A0F4IU78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001056">
        <property type="protein sequence ID" value="KJY25565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25565">
        <property type="protein sequence ID" value="KJY25565"/>
        <property type="gene ID" value="VR44_32125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6996" checksum="D588908F3064E213" modified="2015-06-24" version="1">MGSATVSTFACRAGGMEELSGEPHHEVRGRGRPAGFHEVLDGGIEAQGGVVLEGDSDRFRPWVLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWH1</accession>
    <name>A0A0F4IWH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951037.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25818">
        <property type="protein sequence ID" value="KJY25818"/>
        <property type="gene ID" value="VR44_31520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13287" checksum="86BF6B015FEE66B0" modified="2015-06-24" version="1">MLIGELAEATGTSARALRHYEGAGLISSERLPNGYRVYDERAVVRVRNIRTLLDAGLTLDDVRVFLPCLDGDVAAGPPSPEGLAVARRRLAVLEARVAAQTAARDRLREALGQGEATTPRPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWM4</accession>
    <name>A0A0F4IWM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001124">
        <property type="protein sequence ID" value="KJY25076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951406.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001124.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5693"/>
    <dbReference type="EnsemblBacteria" id="KJY25076">
        <property type="protein sequence ID" value="KJY25076"/>
        <property type="gene ID" value="VR44_33490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3578"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="423" mass="46503" checksum="6C0FA53550D0E756" modified="2015-06-24" version="1">MGAGAPRIFVSHLSGVPVFDPNGDQVGRVRDLVAMLRVGGRPPRLLGLVVEVVSRRRIFLPMTRVTGVESGQVITTGVVNMRRFEQRPTERLIIGELLDRRVTLVASGEEVTVLDVAIQQLPARRDWEIDRIFVRKGKGGALRRRGETLTVEWSAVTGFSLEEEGQGAENLVATFEQMRPADVANVLHHLTPKRRAEVANALDDDRLADVLEELPEDEQVEILGKLKEERAADVLEAMDPDDAADLLSELPEDDKERLLTLMQPDDAADVRRLLSYEENTAGGLMTTEPIVLRPDATVADALARVRQSDLSPALAAQVYVCRPPDETPTGKYLGTVHFQRLLRDPPFTLVSSIVDTDLPPLPPDASLPVVTSYLAAYNMVAAPVVDESGSLLGAVTVDDVLDHLLPDDWRETDFHSEEAVHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX14</accession>
    <name>A0A0F4IX14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000973">
        <property type="protein sequence ID" value="KJY26189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950888.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000973.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26189">
        <property type="protein sequence ID" value="KJY26189"/>
        <property type="gene ID" value="VR44_30685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2592"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="32413" checksum="C208C77C56B4BB28" modified="2015-06-24" version="1">MPMLLIRGTFRAKGFEPDGDTVNFTPDDVADWKLVPGSRPVVPRAFGNAAIRLEGIDALETHYGLEDSPSGRQHQPLPLAHQAADALLTALGFTAVVRDDPERPEKVTSTTPEVVHGYILTRGADIYGRCVALVGKDHQPAFNGYLVQVDEDALKNTVNHQLVKAGLAYPTYYSEFPELLRNALTAAAGEAQDLKKGVWQRDATTTGVKVDGLTSLTADDGAVILPKLFRRLKDYLDLNPRDPSLSCFRAYLAGASDDQFYLQGKAEVLSGMHHVVEVDGCTVRMTHGPTEIVFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXC9</accession>
    <name>A0A0F4IXC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000983">
        <property type="protein sequence ID" value="KJY26103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26103">
        <property type="protein sequence ID" value="KJY26103"/>
        <property type="gene ID" value="VR44_30865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="9252" checksum="6329AE273A1EE455" modified="2015-06-24" version="1" fragment="single">MARVRHWHTGIHQLRARGWTISAIADRLGRDRKTVRHDLTTDLDQILASARERRPNGHINRFKPYLQQRFRGGATNAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXK6</accession>
    <name>A0A0F4IXK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_29300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000907">
        <property type="protein sequence ID" value="KJY26737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950633.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000907.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26737">
        <property type="protein sequence ID" value="KJY26737"/>
        <property type="gene ID" value="VR44_29300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="234"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="356"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY26737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="52107" checksum="4B58646075C59BBD" modified="2015-06-24" version="1">MANRISGEEAWRIKRELLGVDDRTKHRGRAIAPLKGLVREPGTQQRVYRFRFYPTADQAAQLTQTFGACRWVYNEGLALRKEAWEKHRVSLGFAETCRALTGWKRGRETAWLKETSSTVLQQSLRHLDAAFSRFFKGSAKYPKRKSRHRSKDSATYVRTGFRWVEDPECPGTATVTLAKQTTPLDIRWSRALPAGQLPVKLTVTRDRAGRFFLSVLVEEVIAPLPEVFLPGGREPKAVGLDLGVATLVTTDDGEKLPHPRLLAKYGKRLANLQRDLHRKTKGSKNRGKVRERIARVYASIGDVRRDQLDQFTTRLVRENQVLVVEDLSITGILRAGKGRNRRRKAALNRSITDAAWGELLRQLRYKCAWYGRTLVVVDRFFPSTRRCSACHTKGPKLDVSVREWTCAECGTFHDRDENAAVNLRDEGLRLYWAVAMALPPGRVPPSVIRASELVNLVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ11</accession>
    <name>A0A0F4IZ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001011">
        <property type="protein sequence ID" value="KJY25911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950989.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000066_gene6668"/>
    <dbReference type="EnsemblBacteria" id="KJY25911">
        <property type="protein sequence ID" value="KJY25911"/>
        <property type="gene ID" value="VR44_31265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2740"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="15"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="494" mass="51841" checksum="8435143D9A40ED8A" modified="2015-06-24" version="1">MSGEQGQRLYIGGEWVEPDGGHYEVVNPADESVVGLAPEASRAQVEEAARAAAEAFGPWSRTRPEERAAILDRAADVIQREFEPWAELAQAETGAPTGIARGMQVGVGVARFRRYAKGALEPVERGLPPQVTEAGPMGAASVLGALEVRQPVGVVTCITSYNNPWANPAGKVAPALAMGNTVVVKPAPQDPLSVFRMAEALAEAGIPPGVVNVVSGQAVEVGEAAVDSPHVDMVSFTGSTGVGQRIAEVCGRSMKRQLMELGGKGAAVVFGDADLDAAVMGIGTTFSFYSGQICTAPTRVIVQRSVYAQLVEKLTGYLAFMKVGDPAVKGTVVGPVISAAHRDRVESYVELGRKEGARIASGGERPVVGEGDRRGKGFYVAPTLLVDCTNDMRVVREEIFGPVVVVVPFDGGEDEAVALANDSDYGLISYVWSGDAARAFRVARRLRAGGVGVNTIGRNMEAPFGGFKRSGVGRDVGSYALHAYSEVQSIVWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZN9</accession>
    <name>A0A0F4IZN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27124">
        <property type="protein sequence ID" value="KJY27124"/>
        <property type="gene ID" value="VR44_28445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9111" checksum="6EB794E66BD86E1E" modified="2015-06-24" version="1" fragment="single">MGGFGRYLAAALAARFASEGMGMAVVLLALERTGSAAYGAFVLTAWMAPHVLAAPVAGAVAGRARRPRLFYAGTLAGFTAAVAGLAALLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0U2</accession>
    <name>A0A0F4J0U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000844">
        <property type="protein sequence ID" value="KJY27358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950360.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000844.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27358">
        <property type="protein sequence ID" value="KJY27358"/>
        <property type="gene ID" value="VR44_27795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1797"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11754" checksum="919EF65A51A2B145" modified="2015-06-24" version="1">MTQEIRAHGQDRQDAGLDAVVWGSCPAGTGWFWMARHTAWDGTVRRTAHGWRETRDDATREGAAAARRLAAGTRAQVFLRRRAAEYALRILLEESGAAAARRPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0W7</accession>
    <name>A0A0F4J0W7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000925">
        <property type="protein sequence ID" value="KJY26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000925.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000047_gene2133"/>
    <dbReference type="EnsemblBacteria" id="KJY26556">
        <property type="protein sequence ID" value="KJY26556"/>
        <property type="gene ID" value="VR44_29755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2330"/>
    <dbReference type="eggNOG" id="ENOG5030MQE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like_dom" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22743" checksum="DFDB7487796F1D88" modified="2015-06-24" version="1">MRLDHVSYAVARDSFVSTVQWIGSALGAGFVDGGVHPRFGTRNFILPLSGGTYVEVVTTLDHPAADRAPFGQAVARRAAEGGGWLGWVVSVDDIAPVEARLGRTSAEGHRVRPDGYDLRWKQIGLLELMEDPQLPYFLQWLVPTEERPSAGPRTSTTIRGLSIAGDAASIAEFLGEPADHPLDQIDVTWVEDEEPGLVAVEFATAQGPVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J100</accession>
    <name>A0A0F4J100_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_29655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000921">
        <property type="protein sequence ID" value="KJY26596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26596">
        <property type="protein sequence ID" value="KJY26596"/>
        <property type="gene ID" value="VR44_29655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2272"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470299" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="28905" checksum="7B3EDFE832A3A8B0" modified="2015-06-24" version="1">MKLGNLFAVAVLMTPLPFVGMAQPAWAHPTHTVAITGALVVENNPVFGKGSRITRHVFREVNLTHGDPKESFLFVQCAGGESRGELRVTVDLIESDRVTVSALLNFFEGSTCGSTDLEEFQRWNGSIAAGESVKVGLEAYNHEFQSNDGAVANFTVTHNVPERPAKPTDVRARAVRVLCVPRLPCSGKKEVVVKWVDNSVNEIGYSIRDTTTGETVGLPANTTEFTWSGLDPQVKHCFLVRANGDAEVSEWSAPIRAILPGQLSSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1K8</accession>
    <name>A0A0F4J1K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000800">
        <property type="protein sequence ID" value="KJY27754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950189.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000800.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27754">
        <property type="protein sequence ID" value="KJY27754"/>
        <property type="gene ID" value="VR44_26845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1528"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="24724" checksum="C42CB10AC706D164" modified="2015-06-24" version="1">MLQVALNGSRAAGDGGAVPLSPADLAESALAAVAAGAGEVLVHPRTPCGRESLSPRVVGPVLAELRGAGVRVPLVVPAGVAAEPDPAGRLERVGSWEVLPDRAVVPFAEPGAEPLARALLERGVAVDAVVPLGGGAGPEPPARFLAWSPSRYGRVRLVAELAEADPALVAWMRPPPPVPVVLYGRDGAAWPVLRLATRCGAGARIGVGEVLSLPDGRPARSNAELVAAARALWGGVATRTAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1V8</accession>
    <name>A0A0F4J1V8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate carboxyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28260">
        <property type="protein sequence ID" value="KJY28260"/>
        <property type="gene ID" value="VR44_25780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1260"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="36523" checksum="8BD06F70871FC263" modified="2015-06-24" version="1">MSGVLHESVERGAAAAAEILDCTLRDGSYSVDFRFTEETIRAVLAGLENAGLNLIELGHGLGLNAGEALSRPSLVADERCFAVAAETLHRAEWGMFCIPGLAEPDHLTRAAGAGMGFVRIGVDITDVSPAGRFVELAKELGLRTFVNLMKTNVLDDEGVVAAVRRCAGFGADSVYLVDSVGGYLPHEVEELFRRVGAEVAVPLGFHGHDNLGLANANALAAARGGARYVDATLDGIGRGAGNTVTEAFAAILTRHRTGTGYDYRALAQLSESVVRPIPRLHDDRTFQVLGGLTQTHSSFFPLITRCAEAADVDVFELMTAVAEVERVRPTEQLVKELAVSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2N2</accession>
    <name>A0A0F4J2N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000857">
        <property type="protein sequence ID" value="KJY27221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950424.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000857.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27221">
        <property type="protein sequence ID" value="KJY27221"/>
        <property type="gene ID" value="VR44_28140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1872"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27269" checksum="CC3583DC411A6B26" modified="2015-06-24" version="1">MAAFPAVLRSEWTKIRTVASTTWTLASALVVTVGLGALLCSFTASRFKDMTAAEKLSFDPIMISFAGMSLGQLAMIVFGVLVVGTEYGSGMIRTSLAAVPRRGTFLLGKLTAATALALAVGLATSFLSFFIGQALLGDHGTDLGREHALRAVLGAGLYMALIALFSMGVTAVLRSSILALGILMPFFFLISNILHAFASTRKVAQYFPDQAGSKIMQTVPDAVNQVQAPYGPWGGLGIMALWVLAAVAGGYLVLRKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2Q8</accession>
    <name>A0A0F4J2Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949837.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000714.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5951"/>
    <dbReference type="EnsemblBacteria" id="KJY28617">
        <property type="protein sequence ID" value="KJY28617"/>
        <property type="gene ID" value="VR44_24995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1087"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="28308" checksum="23E624EF038039EF" modified="2015-06-24" version="1">MAGVARRRLDAELVRRSMARSREHAAQLIAAGRVTVGGTTATKPATQVETSAALVVLKDDSDPDYVSRGGHKLAGALAAFRPRGLAVEGRRALDAGASTGGFTDVLLRAGVAHVVAVDVGYGQLAWSLQSDERVTVKDRTNVRELTLELIDGVPVDLVVGDLSFISIGLVLPALVRCTAPDADLVLMVKPQFEVGKERLGSGGVVRSPELRAEAVREVAAQAWKLGLGVLGVTASPLPGPSGNVEYFLWLRAGAPALDPGDVDRAVAEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J331</accession>
    <name>A0A0F4J331_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_27835</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000846">
        <property type="protein sequence ID" value="KJY27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950368.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000846.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27341">
        <property type="protein sequence ID" value="KJY27341"/>
        <property type="gene ID" value="VR44_27835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1805"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="3"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="26909" checksum="AEA640828F5DC238" modified="2015-06-24" version="1">MDLLLWGVYPYVSVTLLIAGLVWRARYDAFGWTTHSSQLHESRLLRIGSPLFHFGMAFVVAGHVVGLLVPMSWTDALGLDDHAYHLMAVSTGAVAGVAAAAGIGVLVQRRLRTPAVRKARVRGDRLMYAVLLGALALGLTATVLNSTGQTDGYNYREGVSVWFRSLFALSPDYQLMAAAPLAFRLHVLFGFTLFALIPYSRLVHMFSAPLKYLFRPFVVYRRRDPRLTSNRPDRRGWERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J493</accession>
    <name>A0A0F4J493_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000677">
        <property type="protein sequence ID" value="KJY29090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003953493.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000677.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene193"/>
    <dbReference type="EnsemblBacteria" id="KJY29090">
        <property type="protein sequence ID" value="KJY29090"/>
        <property type="gene ID" value="VR44_23770"/>
    </dbReference>
    <dbReference type="GeneID" id="63981650"/>
    <dbReference type="GeneID" id="67401070"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.727"/>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17829" checksum="0D8F10F093DB8DAB" modified="2015-06-24" version="1">MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLTVRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4G4</accession>
    <name>A0A0F4J4G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000707">
        <property type="protein sequence ID" value="KJY28714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949791.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000707.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28714">
        <property type="protein sequence ID" value="KJY28714"/>
        <property type="gene ID" value="VR44_24725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.942"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="19114" checksum="D61D5BE9C95517D1" modified="2015-06-24" version="1">MDTTERIGPPLTGDERETLRAFLDFHRATLAWKCDGLTDEELRRQASPPSTLSLLGLVRHMAEVERQWFRRTIGGDAEVPHLWSDSRDFQAAYDASGATRAEAFAAWEAEVAHSRAVEAAAESLDVTVYVPRWEEEASLRLVMLHMIHEYARHNGHADFLREAIDGTVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4X9</accession>
    <name>A0A0F4J4X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949708.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28879">
        <property type="protein sequence ID" value="KJY28879"/>
        <property type="gene ID" value="VR44_24275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.835"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="19045" checksum="17B81479AEDD6E06" modified="2015-06-24" version="1">MTTNNWAAFEKAEPDFAEAVRARFAQFPHHVLATLRKDGSPRLTGLTVEFRGGELWLGMMAGSMKARDLQHDPRFALHTNPGPDDTMPDGDVRISGRAVEIVDPPELHRYAEEKDTPHPFHLFHADLTEVVHTTVDGEELVVRTWTPTRGLHTLRRGNDDEPPREVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J513</accession>
    <name>A0A0F4J513_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000651">
        <property type="protein sequence ID" value="KJY29350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949494.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7541"/>
    <dbReference type="EnsemblBacteria" id="KJY29350">
        <property type="protein sequence ID" value="KJY29350"/>
        <property type="gene ID" value="VR44_23120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.563"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24140" checksum="0CA6B852C00E5EFE" modified="2015-06-24" version="1">MVQKAKILLVDDRPENLLALEAILSALDQTLVRASSGEEALKALLTDDFAVILLDVQMPGMDGFETAAHIKRRERTRDIPIIFLTAINHGPHHTFRGYAAGAVDYISKPFDPWVLRAKVSVFVELYTKNCQLREQAALLRLQLEGGGSNGDGSKEAAGLLAELSARLAAVEEQAEALTKQLGEDSADAAVVATAAHLERKLTGLRRALDALEPGAGGTAPVLPAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J594</accession>
    <name>A0A0F4J594_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_24000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000685">
        <property type="protein sequence ID" value="KJY28999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949656.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000685.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5543"/>
    <dbReference type="EnsemblBacteria" id="KJY28999">
        <property type="protein sequence ID" value="KJY28999"/>
        <property type="gene ID" value="VR44_24000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.778"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="84"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="516" mass="56101" checksum="F0C85F44F685109A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5C9</accession>
    <name>A0A0F4J5C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000682">
        <property type="protein sequence ID" value="KJY29039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949641.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000682.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29039">
        <property type="protein sequence ID" value="KJY29039"/>
        <property type="gene ID" value="VR44_23920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.759"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="36877" checksum="40E94B7EDFF6C027" modified="2015-06-24" version="1">MAVTLAEVAVRAGVSPATVSRVLNGGYPVAGDTRTRVERAVEELGYIANASARALAAATSDLVGILVHDIADGYFGILAGSLQGALDPAGGGEPRRLAVVCNTQGAPAAETAYLTLLEGQRAGGVVLTGAAAEDPEHTAALTLRVARMAAAGTRVVLCGRPPVPVPEALPVATVVFDDRGGAFRLAEHLLTLGHRRIAYIAGPPGRSTTRERLAGHREALRRHDPALPEACDALTVHAGFERSAGYDATRELLRRGEPFTAVAAANDTAAAGVAAALREAGLRIPEDVSVTGFDDLPFSQDTAPALTTVRVPLREAGALAAQLVTGRRPLPPGGITTLPTELMVRASTAPPPPARRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5U2</accession>
    <name>A0A0F4J5U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000664">
        <property type="protein sequence ID" value="KJY29204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29204">
        <property type="protein sequence ID" value="KJY29204"/>
        <property type="gene ID" value="VR44_23520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.646"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="16030" checksum="E36DCFB236A8A56E" modified="2015-06-24" version="1" fragment="single">LLDSMTEIRDHERRFSEGGGAIELDAATRYKVLAAFDGYLETLPEESLVRPDSYRVKDVVGRRGVGIGSAGLPSYNILLEGHSDALENDVVIYLKQAQTPAVSRHITDRAVREYFQHEGHRTVISQRALQAHADPWLGWTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Y9</accession>
    <name>A0A0F4J5Y9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5189"/>
    <dbReference type="EnsemblBacteria" id="KJY29249">
        <property type="protein sequence ID" value="KJY29249"/>
        <property type="gene ID" value="VR44_23430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.628"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25027" checksum="EBC1936A76403390" modified="2015-06-24" version="1">MTDRKSELAANLARVEERIASACEAAGRKREEVTLIVVTKTYPATDVRLLADLGVRHVAENRDQDAAPKAAACADLSLNWHFVGQLQTNKVRSVAGYAHVVQSVDRPKLVTALSAAAVDRGREIGCLVQIALDAESGERGTRGGAAPEQMAELADLVAAAPGLRIDGLMTVAPLAGRYAGREQAAFERMMELSSGLRAAHPAATMVSAGMSADLEQAVLAGATHVRVGTAVLGARPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N7</accession>
    <name>A0A0F4J7N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949106.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30210">
        <property type="protein sequence ID" value="KJY30210"/>
        <property type="gene ID" value="VR44_21040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8940"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="19163" checksum="E047ECC2C3E38462" modified="2015-06-24" version="1">MKERQAAARPDGGGGADRGRRESREERADRQWQELMQEIRVAQTGVQILFGFLLTVAFTPHFQGISATDKAIYVVTVVAGSLAAGALIGPVSFHRIVSGRRIKPEAVVWASRLTFAGIVLLLATFTSALFLVLRVVTHGALVPCLVSGVVAWYLLCWFALPLWARERHTDQNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Q5</accession>
    <name>A0A0F4J8Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000584">
        <property type="protein sequence ID" value="KJY30174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30174">
        <property type="protein sequence ID" value="KJY30174"/>
        <property type="gene ID" value="VR44_21070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8893"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22057" checksum="C131D43CB4FE44EE" modified="2015-06-24" version="1" fragment="single">VLREHLVPRGATLVELDMRTLTPEALCGELLTHGATALLLLLGHPDPAVPVVRAVRRDPRLGGILIGAPAGQPEFTEWATLLGAEGTAVPFLRYLPEHLGPLGTRVGTALRARLGEAPSFVAFEGYDTVTVLAEVLRSPRGDDPWADVAVQGTRGEIRFSRVPGIGVRQWAWAPVQVADRDPADPGRFRVLHAAGAPRVTVRPECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J984</accession>
    <name>A0A0F4J984_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949038.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6947"/>
    <dbReference type="EnsemblBacteria" id="KJY30379">
        <property type="protein sequence ID" value="KJY30379"/>
        <property type="gene ID" value="VR44_20660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8847"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="40385" checksum="C2008443ACCC4668" modified="2015-06-24" version="1">MGQLTGGDPSLLRRINSAVVLRALRAAESPTLTDLTRVTGLSRPTVEGVVEGLMGAGLVVEADAEEGARRQGRPARRFRFRAEAGHLLGIEIGSHRVAVLLSGLDGRVIGAGTKDVAESASADERLEKVRAAVADLLRRAGIPRDSLRAVGVGSPGIVEADGTVRLGTALPGWTGLPLGERLRRSFRCPVRVENDANAAAVAEHWKGAARDTDDMVFVMAGLSPGAGSLIGGRLHRGFGGAAGEIGALHLLGREATPERLLSTTGEPLHPLDEPAVAEVFAMARRGDERAVAAVERFLQRLVHDVAALVLAMDPELVVVGGWAAGLDGVLEPLRRELERYCLRPPRVALSLLGEAAVATGALRLALDHVEQELFAVERTVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9E4</accession>
    <name>A0A0F4J9E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000535">
        <property type="protein sequence ID" value="KJY30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30820">
        <property type="protein sequence ID" value="KJY30820"/>
        <property type="gene ID" value="VR44_19420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8493"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15648" checksum="66B46C5D57D3A75B" modified="2015-06-24" version="1" fragment="single">MRVVSLVPSLTEAVAVSAPGLLAGVTDWCTHPAGLGEARRIGGTKNPDVRAVVELRPDLVIANEEENRAPDLAELRAAGLEVLVTEIRDLPQAFSELDRLLVGSLGLERPRWLDRAEEAWAAVEPVGDLAAFVPIWRRPWMVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9H1</accession>
    <name>A0A0F4J9H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000524">
        <property type="protein sequence ID" value="KJY31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948755.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000524.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31002">
        <property type="protein sequence ID" value="KJY31002"/>
        <property type="gene ID" value="VR44_19105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8425"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="7"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="531" mass="57569" checksum="A5CD50D12407012B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Q9</accession>
    <name>A0A0F4J9Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000517">
        <property type="protein sequence ID" value="KJY31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948709.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000517.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4109"/>
    <dbReference type="EnsemblBacteria" id="KJY31107">
        <property type="protein sequence ID" value="KJY31107"/>
        <property type="gene ID" value="VR44_18875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8389"/>
    <dbReference type="eggNOG" id="ENOG502ZCFK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="37737" checksum="6598C77804D8C996" modified="2015-06-24" version="1">MPELRVVAVSNDGTRLVLKAADSTEYTLPIDERLRAAVRNDRARLNQIEIEVESHLRPRDIQARIRAGASAEEVAQLAGIPVDRVRRFEGPVLAERAFMAERARKTPVRRPGENTGPQLGEAVQERLTLRGADKDSVQWDSWRRDDGTWEVLLVYRVVGEPHSASWTYDPPRRLVTAVDDEARSLIGESDDLPSTPEPSFPFVPRIARLPRDRPLDRALDRQIERPAAPPPAPEPEEERDTLTSLLEAVPSFRGDLVVPERTDAADEEAETEEPPAAAASAGAGAAYADVLMPRTVAGHRERLTGTTDRQAEADGVRPGRRAAVPSWDEIVFGTRRKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBK4</accession>
    <name>A0A0F4JBK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948667.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31184">
        <property type="protein sequence ID" value="KJY31184"/>
        <property type="gene ID" value="VR44_18670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8343"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14607" checksum="49140FE8D4112A4C" modified="2015-06-24" version="1">MAGLLPRADVLIAIMGAPHTGDLVTSAFRLSQALLARGARVHLWTCGHATGLTRQALGPAKPRNVVDWAREYPTTAALAAELLAAFPTTLHWYACRFCSQERGADAHIPGIRLRAPFKFTEHLDAADKAFFLGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBV3</accession>
    <name>A0A0F4JBV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000502">
        <property type="protein sequence ID" value="KJY31289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31289">
        <property type="protein sequence ID" value="KJY31289"/>
        <property type="gene ID" value="VR44_18445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8284"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="669" mass="67510" checksum="381B7B15E1DD8B12" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE95</accession>
    <name>A0A0F4JE95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000408">
        <property type="protein sequence ID" value="KJY32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32510">
        <property type="protein sequence ID" value="KJY32510"/>
        <property type="gene ID" value="VR44_15825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7573"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="9650" checksum="96E3A0D2CEC8059C" modified="2015-06-24" version="1">MRGVAGGTARTASGRPSTSASGKAARPVWVAYTRNHGWSPARSRSSMAAYVVQPCGRNTFRIQGCPPHSTSTGVASSRARAAATSSGAGGAVTAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEE1</accession>
    <name>A0A0F4JEE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948278.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32118">
        <property type="protein sequence ID" value="KJY32118"/>
        <property type="gene ID" value="VR44_16580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7748"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="34535" checksum="911099164FBDB40F" modified="2015-06-24" version="1">MSRSRPHRVAVLVLEAGAKPLDVGIPAQVFSTRASMPYEVRVCGAAPGLVTGGDGLSYHVTHGLEALEWADIVFVPGYRFPDREDPPRAVVEALTAAHARGARLAAISTGAFALAATGLLDGRRATTHWHYTRALKAKHPLVRIDENVLFVDEGSVLTSAGAASGIDLCLHILRGDLGVAAANHAARRLVAAPYRSGGQAQYLPRSVPEPLGERFAATREWALQRLGEPLTLEALAQHAAVSPRTFSRRFAEDTGYTPMQWIMRARVDVARELLERSGRSVEQIAADVGLGTGANLRLHFQRILGTTPTEYRRTFTRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEL9</accession>
    <name>A0A0F4JEL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000393">
        <property type="protein sequence ID" value="KJY32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32797">
        <property type="protein sequence ID" value="KJY32797"/>
        <property type="gene ID" value="VR44_15225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="11812" checksum="171E19467C77D4B7" modified="2015-06-24" version="1">MPADCPVEPGPASLLVHRHDELLNHMYNALVRGDLRRTDAGWLLEPSTVIEPMGSGRASDALRVLSRTKRSTDRYLRRRGLRRPKVQWDRFRALAEPEPPTDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF44</accession>
    <name>A0A0F4JF44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_16060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32398">
        <property type="protein sequence ID" value="KJY32398"/>
        <property type="gene ID" value="VR44_16060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7633"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35960" checksum="43926CAA5142D7B9" modified="2015-06-24" version="1">MTTVNPAPVIPDGRKPSPPAPSGIPQRPRRPNRERLHGLLMSAPALGGLIAFVGVPFVYAVVLSFYNVRLGSPLPPRFFGIEQYRRIFTDPDMSGPFLRALVNNLTFAVVVVPLQTALALGLAILLNRKLKAIGVFRSLFFLPVVFPMALVAVIWRLILARSGDGLLNSALHTVSFGNWGAFDWLGNGLTAMASIIVLSVWQGVGFQMVILLAGLQQIPGELYEAAELDRASPWQQFRHVTLPGIRGTLVFVAMLTSVLSFRVFDQVYVLVKGGGLDEDATRTVMYQAVTTAFDQHNIGQASAITVVFFLIVVVLTLIQRRVVRTGNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFF1</accession>
    <name>A0A0F4JFF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_14610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947909.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33067">
        <property type="protein sequence ID" value="KJY33067"/>
        <property type="gene ID" value="VR44_14610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7248"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470425" evidence="6">
        <location>
            <begin position="37"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="7">
        <location>
            <begin position="404"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="525" mass="52885" checksum="A88CD41A7A458C08" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFT5</accession>
    <name>A0A0F4JFT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="3" type="ORF">VR44_15620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000403">
        <property type="protein sequence ID" value="KJY32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948095.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000403.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32618">
        <property type="protein sequence ID" value="KJY32618"/>
        <property type="gene ID" value="VR44_15620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7525"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="23967" checksum="F6EAA691F432FB5F" modified="2015-06-24" version="1">MRALIVTAVAAEADSAASGLTPHQDPVTPEPRTLPGGYLITRRDLPGLAADVLVGGVGPASAAAATATALALADYSLVISAGIGGGFAPAAPLGSLVVADALVAADLGAETPEGFVPVQELGFGRNVHLPPADLAARAAEATGALLAPVLTVSTVTGSAARAAELAARHPLAGAEAMEGFGVAEAAAAHGLPVLEIRAVSNAVGPRDRAAWRIGDALAALADGFRALGPVLVTWGERHDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFV4</accession>
    <name>A0A0F4JFV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000369">
        <property type="protein sequence ID" value="KJY33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33222">
        <property type="protein sequence ID" value="KJY33222"/>
        <property type="gene ID" value="VR44_14310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7210"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="42355" checksum="57B9D0C620408AD2" modified="2015-06-24" version="1">MPADFHPEEPARRPEGFARAAGARESHVWDRSFRAWDLYTAAVWSATAAFVLTAGTPSPRYRIAALALLVLLIPWYVRAGRPLLLAESAPATWPCLRYLGVTLVLFLPAASMMDEVRLIVFALAPHFFMLLSLRRALVWRPPAHEVFLNAVSALVGFAFAAFFGAWTIRIIEQSRERASLIAELDASREEVARLSAEHGAHTERERMAREIHDTLAQGFAGLLMLVQAVRAELDADPGRARRHLGLMEATARQNLAEARALVAGGAPADLDGGSLPDAVRRLAARHDPPAAVTVTGRARPLPPGLEAVALRTCQESLANAAKHAGPGALAAVSLTYAEDGLTVEVRDTGRGFRPSAPTSGYGLRGLAARAADAGGTAVVRSAPSEGTTVTVTLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH06</accession>
    <name>A0A0F4JH06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000423">
        <property type="protein sequence ID" value="KJY32261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948216.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000423.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32261">
        <property type="protein sequence ID" value="KJY32261"/>
        <property type="gene ID" value="VR44_16265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7706"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="687" mass="73201" checksum="412EABA5D7F6356D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHE2</accession>
    <name>A0A0F4JHE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ORF">VR44_14385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947872.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3327"/>
    <dbReference type="EnsemblBacteria" id="KJY33173">
        <property type="protein sequence ID" value="KJY33173"/>
        <property type="gene ID" value="VR44_14385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7226"/>
    <dbReference type="eggNOG" id="COG0311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21040" checksum="40D966375A0B0E7D" modified="2015-06-24" version="1">MSNPPVIGVLALQGDVREHLIALAAADAVARPVRRPEELAEVDALVIPGGESTTMSKLAVLFGMLEPLRERVRAGMPVYGTCAGMIMLADKLLDGRDDQETLGGIDMIVRRNAFGRQNESFEAKIDFAGIAGGPVEGVFIRAPWVESVGASAEVLATYDGHTVAVRQGNVLATSFHPELTGDDRVHAYFVDMVRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ57</accession>
    <name>A0A0F4JJ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042814156.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene722"/>
    <dbReference type="EnsemblBacteria" id="KJY33813">
        <property type="protein sequence ID" value="KJY33813"/>
        <property type="gene ID" value="VR44_13175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6853"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18334" checksum="D85311BA426FD7B0" modified="2015-06-24" version="1">MHSGVVVSRSADSRNRQPSPSVDAVSLAIIEQLQEDGRRPYASIGKAVGLSEAAVRQRVQKLLDQGVMQIVAVTDPLTVGLRRQAMVGINVEGDLDPVADALTAMAECEYVVMTAGSFDLMVEIVCEDDDHLLETINKKIRTLPGVRSTESFVYLKLKKQTYMWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJK8</accession>
    <name>A0A0F4JJK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000291">
        <property type="protein sequence ID" value="KJY34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947421.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000291.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34400">
        <property type="protein sequence ID" value="KJY34400"/>
        <property type="gene ID" value="VR44_11945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6470"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471108" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13185" checksum="32AB5DB7914AA6E7" modified="2015-06-24" version="1">MKRFSTLLAAVVLTTGAVLATSAAAEAADCRSGYFCVWTDANFDGLKIEHSGDDHWWEGDMFKHDSSWANHGVSGPGVLDHVKVYEGRELLGPVTLCLAPGQEVGYNAGANDRGGSHTWTKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJU7</accession>
    <name>A0A0F4JJU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000276">
        <property type="protein sequence ID" value="KJY34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34612">
        <property type="protein sequence ID" value="KJY34612"/>
        <property type="gene ID" value="VR44_11605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11815" checksum="BB62D227DD4F7D5E" modified="2015-06-24" version="1">MVLAELLGCPGGDRVGDRFALSPAVLEEFAVGVAADPHDAVAEAGQQVEDLGGLRAGGDVAGQHDAIGGAEVWFGEYCFQGRQDSVDVGQNGYTAQHAHHCRPEAAAGCDLSPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKP5</accession>
    <name>A0A0F4JKP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000253">
        <property type="protein sequence ID" value="KJY34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34912">
        <property type="protein sequence ID" value="KJY34912"/>
        <property type="gene ID" value="VR44_11165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="18312" checksum="A219B051BA762AAB" modified="2015-06-24" version="1" fragment="single">LGPASVVIANAGIAVAGPFATCEASLFDRVVEVNLIGSANTARVFLLQLTRTGGYFLQVASTAAFGSAPLMSAYCASKAGVESFAQALRTEVRPAGVGVGIAYLHWTGTDMIAGLDDHPVLRTLRSHQPAPARRVHSPERVAEWLVRGVERRAVSVYAPPWLRLVQPLRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL36</accession>
    <name>A0A0F4JL36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000245">
        <property type="protein sequence ID" value="KJY35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947232.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000245.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35052">
        <property type="protein sequence ID" value="KJY35052"/>
        <property type="gene ID" value="VR44_10920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6064"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="40719" checksum="4097FF41C4E2711A" modified="2015-06-24" version="1">MDRLTNTIRPYAWGSTTAIPALLGVEPTGEPQAEMWMGAHPGAPSRLDRGAGGTTLSAVIAADPEGELGSAAVAKFGPALPFLLKVLAAGAPLSLQVHPDLAQAKAGFEDEERRGVPIDAGHRNYKDANHKPELICALTPFDGLCGFRRPAEAADLLEGLGVDSLKPYVDLLRAHPEEAALREVLTAVLTADRAEMAHTVAETAAAAERLGGPYAPYAGLVHDYPGDPGVIAALLLNHVRLQPGEAMFLGAGIPHAYLDGLGVELMANSDNVLRCGLTPKHVDVPELLKVVVFEPSAPGVLRPEGDGEEVYETPIDEFRLSRFALAAGGAPRAVPEATPQILLCTAGRCTASSARSGELVLVPGESVFVPAGEKVELSGNGTVFRATVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLA0</accession>
    <name>A0A0F4JLA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947684.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33746">
        <property type="protein sequence ID" value="KJY33746"/>
        <property type="gene ID" value="VR44_13350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6906"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="101"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36371" checksum="EBD99C5AF7A33DA9" modified="2015-06-24" version="1">MRIRRTRAERADRLRRAAGRLRGWGGVSAMAAACAMTAAAVLLPLAHSSPGTGHHPAVVSDPASVDAAPFTLTDTCQDPEASLRPSALDGPTIERIRKAGKLVAGVDQNSFKWGYRNPDGHLDGFDIDLVKAIAKDILGNEEAVIYRAIPTSQRIPALQEGRVDIVVRTMTINCKRLEDVAFSTAYFEAGQQVLAPKGSPITGYDASLKGRRICTAAGSTAEAALKSQGYGAVPVSVPNQLDCLVRLQLGEVDGIITDNALAAGQAAQDPSVQLVGAPFTREFYGVAMNKGASDLVRRVNKVLENYRAGGDQSPWATSYRKHFEDVLPKAAVPPAPKYREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMT2</accession>
    <name>A0A0F4JMT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947069.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35495">
        <property type="protein sequence ID" value="KJY35495"/>
        <property type="gene ID" value="VR44_10035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5606"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23681" checksum="4BFDD39EA5A2A1FD" modified="2015-06-24" version="1">MSGGSDEGPRRVGRPRADRLRAPGDRPPREELLCAAAELFTVRGYAATTTRAVAERAGMRQATMYHYFGGKEELLAELLESTVAPSLALSRRLRGETGRPAALRLWELCRSDVLLLCGGPYNLGALYLLPELDSPRLEPFRRMRDELRDNYRALLEATPLGAELAGDTAALALRNDLVFGLIEGVMLIRRSDPARPVAAFAEAAADAALRIAGVAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMY1</accession>
    <name>A0A0F4JMY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000214">
        <property type="protein sequence ID" value="KJY35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947052.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000214.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35545">
        <property type="protein sequence ID" value="KJY35545"/>
        <property type="gene ID" value="VR44_09940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="49220" checksum="FB7EAB167C5BDAC9" modified="2015-06-24" version="1">MSALEPRISATPAAPSTPPGGILGPAYRTLSVGIISVIFLIAFEATAVGTAMPVAARELDGIGLYAFGFSAYFTTSLFGMVLAGQWADRQGPLRPLSVGIGGFAAGLVCSGTATVMGVFVLGRAVQGFGGGLVIVALYVVVSRAYEERLRPAIMAAFAASWVVPSIVGPLAAGTVTERLGWRWVFLGIPVLVVVPLIVALPAIRRTASGPVETTGEPAAFDRRRIRLALGISVGAGLLQYAAQDLRWLSLLPAAAGAALLVPAVLGLLPRGTYRARRGLPSVVLLRGVAAGAFIGAESFVPLMLVTQRGLSPTLAGFSLALGGVTWALGSWVQSQGRTAPYRERLMVAGMVMVALAIAAAPAVLIESVPVWTLALAWAVGSLGMGLVIGSTSVLLMRLSAPEEAGANSAALQISDAVANVVLLAAGGAAFAALGGGAVGAGHALDAGGGASHPAAFLVVFLPMACVALVGAWVATRLHERPAGKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNR8</accession>
    <name>A0A0F4JNR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000194">
        <property type="protein sequence ID" value="KJY35850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946883.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5137"/>
    <dbReference type="EnsemblBacteria" id="KJY35850">
        <property type="protein sequence ID" value="KJY35850"/>
        <property type="gene ID" value="VR44_09030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5069"/>
    <dbReference type="eggNOG" id="COG2867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16302" checksum="F6CAD12A578538B4" modified="2015-06-24" version="1">MAEHTSSSITIDASPAEVMAVIADFARYPEWTGEVKEAEVLSTDAEGRAEKVRLLLDAGAIKDDHTLSYSWKGQDEVSWTLHKSQMLRQLDGSYRLAPLDGGRRTEVTYQLTVDVKIPMLGMIKRKAEKVIIDRALAGLKKRVESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPJ2</accession>
    <name>A0A0F4JPJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946806.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36100">
        <property type="protein sequence ID" value="KJY36100"/>
        <property type="gene ID" value="VR44_08625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4867"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="28210" checksum="A2095FE142D756D3" modified="2015-06-24" version="1">MTSALPYALIATDLDGTLLRAGDTVSARSCAALATARAAGARHIVVTGRPVPQIRHVLDDLGYTGLAVCGQGAQVYDAARGLLLHSVSMDRGLAEMALGKIEAEIGEVYTAVNQEGLDAEMLIGPGYRMWHPHLPTVRVPKRGDLWSAPITKVLLQHPLLDDDELTRVARSVVGDLVNVTMAGEHTVELQPPGIDKASGLARAAEALGLAASSTIAFGDMPNDVPMFAWSAHGVAMANAHRELVAVADEVTLSNEADGIAVVLERLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQA7</accession>
    <name>A0A0F4JQA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35116">
        <property type="protein sequence ID" value="KJY35116"/>
        <property type="gene ID" value="VR44_10825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6015"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="32010" checksum="B1C45FACB39386F2" modified="2015-06-24" version="1">MGTPWRGSRMGTWSGDELDLGAYLARIGLGGRARELRPDLRTLYEVHRAHTAAIPFESLDVLLGRPVALEVKALEDKLVRGRRGGYCYEQNSLLAAALERIGFEVSGRGARNRTRGESLLAVTHAALVVTVEGEPWLCDAGFGYQGPREPVPLGRPGAEVRQGPWTFAVGEEEDGLLVLRIRRGDAWRDLYAFSPQRYHPVDYVVLNHYSSTHPRSSFIGRTLVQLPGDAVRKTLVGRELMRLYPDGRTEREPVAPEGLPGLLDREFGLRLPERDAAELVRIHRSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQR8</accession>
    <name>A0A0F4JQR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein rarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_08585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946799.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36093">
        <property type="protein sequence ID" value="KJY36093"/>
        <property type="gene ID" value="VR44_08585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4859"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="34834" checksum="4D97C3F38D31F674" modified="2015-06-24" version="1">MKADNEQRTGLLYGFGAYGMWGLVPLFWPLLMPSGAIEILAHRMVWSLAVVAVALLALRRWRWIGELVRRPRKLGLTALAASVISVNWGLYIWSVNNGHVVEASLGYFINPLVTIALGVLVLGERLRRAQWAAVAVGLAAVVVLAVGYGRPPWISLALACSFAVYGLIKKKLAMGGLESLTAETALLFLPALGYLLWLGVEGRSTFTSQGLGHSALLASTGLVTAIPLICFGAAAIRVPLSTLGLLQYLAPVFQFTLGVLYFHEAMPPERWAGFGLVWVALVVLTWDALRTSRRSRARLAGAEAEAEAVAAAAGPASAPAPSREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR28</accession>
    <name>A0A0F4JR28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35386">
        <property type="protein sequence ID" value="KJY35386"/>
        <property type="gene ID" value="VR44_10200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="29554" checksum="37D3F5FFC5047B0D" modified="2015-06-24" version="1" fragment="single">MTPRQAGERAAAVLDEIRTAVVGKAEPLALVMLGILAGGHVLIEDLPGLGKTLLARSFATTLGLDFSRVQFTPDLLPSDVTGAPFYDQRTADMVFRPGPVFAQLLLADEINRTPPKTQAALLEAMAESQVSVDGTTRPLPDPFVVVATANPIEYEGTYSLPEAQLDRFLLRVRMGYLTPAEEAGMLRARVDRAAPEAVLRTLSGPGEVLAMRAAVERVEVDDDLLDYAVALVGATRAHPHVQVGASPRGGLALVQLARARAVLELRDYVTPEDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR66</accession>
    <name>A0A0F4JR66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946746.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36248">
        <property type="protein sequence ID" value="KJY36248"/>
        <property type="gene ID" value="VR44_08330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4565"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="17520" checksum="3EE3F1D308569396" modified="2015-06-24" version="1">MFEIRVICTKPEAPDIIRALSEVFVTGPVRQHPTRDRDRVRLYVTAEQAVNRWPAPETAYAKAPSIISEIGWTARGARDCLHGVHVREFWLRKAALLDRIALTDDDPVHGDAATLATEAARRLIDLDGARALDHPDSTRQPRGYVRQEYAAWIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRL0</accession>
    <name>A0A0F4JRL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_06835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946475.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36987">
        <property type="protein sequence ID" value="KJY36987"/>
        <property type="gene ID" value="VR44_06835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3447"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117124" description="Glucanase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="32955" checksum="2BD362A0A6F453DB" modified="2015-06-24" version="1">MPKSVRAASALLAGLLAGGLALLPAGPAYAADPTTMTSGFYTDPDNSALRWTTANPGDGRAAAIRASIANTPAARWFGNWSGDIAAAAGSYAGRAASVGKLPVLVAYNIPDRDICAGQSGGGAGSRAAYESWIAAFAGGIGNRPAVVILEPDALGHESCMTAGQIAERNAMLKYAIAQFNAKAPNTWVYLDAGNAGWIGATAMAQQLAAAGVGGAHGFALNVSNYFTTDQNSSYGNAVNSALRPYGYTKPFVIDTSRNGNGSNGQWCNPAGRRTGTPSQRGGGAEMLLWIKIPGESDGNCGVGAGSSAGQFLPEVAYKMIYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRU8</accession>
    <name>A0A0F4JRU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000151">
        <property type="protein sequence ID" value="KJY36554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946646.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36554">
        <property type="protein sequence ID" value="KJY36554"/>
        <property type="gene ID" value="VR44_07770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20905" checksum="B5C2FA1EAF4D6793" modified="2015-06-24" version="1">MGRPKQFDPEAAVEQAMQVFWRQGYAATTPQDLVDALGIGKGSLYHAFGSKHALFELALRRYRDSQAVAVIELLGGEGPVKDRLRAALRMLVEMDLTDPDRRGCMAVNTAAELAGADEVAAELVRRMFDRTEEALRALVEEGRRSGEISPERDARAVGSMLLSTAVGLRLLARVAEGPERLALVVEATVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSG1</accession>
    <name>A0A0F4JSG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946303.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2613"/>
    <dbReference type="EnsemblBacteria" id="KJY37307">
        <property type="protein sequence ID" value="KJY37307"/>
        <property type="gene ID" value="VR44_05925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2399"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="40709" checksum="9D8A88DC32760E1E" modified="2015-06-24" version="1">MAGARVETLRARARMLSHRVRTALRKSAVDYFRGDASDWLAFAGLLLTVPAIACGTLMLPVWFSPSALVLPIVAGGLLLRPASLLGLYAASATALIVEALVLGPYTEGPARVTPGTVLVVAACGFFGLIIAQFRSRVGVPWRRGGTMLFDLRERIRVQSKLPALPPGWHREMALRPAGGQSFSGDFVVAARTNGGRTLEVVLTDVSGKGMEAGSRALLLSGAFGGLLGALPPQDFLPAANGYLLRQDWDEGFATSIHLVLDLETGDYELLSAGHLPALQLSAGTGRWQERSGEGPLLGVYDGAEFEPARGNLRPGDVLMLFTDGLVETADREISEGIDRLTGEADRYVAAGWEGAAWHLIEKVAKDVNDDRALLLIRRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSR1</accession>
    <name>A0A0F4JSR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946356.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000116.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37215">
        <property type="protein sequence ID" value="KJY37215"/>
        <property type="gene ID" value="VR44_06215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2996"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="19029" checksum="9BFADEF7CC7C3C50" modified="2015-06-24" version="1">MSADTPRRIALLRHAKADWPQVADHDRPLADRGRRDAPAAGRKLAETGITFDLALCSTAARTRETWKLAVQELPYRPRTSYDERVYDASPGELIALLNETPDEVDDLLVIGHNPGMHALADILSGRAEGDTQARMNRTGFPTAALAVVSFTGSWKSLEPGVGTLLDYWTPKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT02</accession>
    <name>A0A0F4JT02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_08550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946792.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene968"/>
    <dbReference type="EnsemblBacteria" id="KJY36086">
        <property type="protein sequence ID" value="KJY36086"/>
        <property type="gene ID" value="VR44_08550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4852"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14676" checksum="47C3C55E58120419" modified="2015-06-24" version="1">MPEPTVSTGAVTAADYFHSYSVVGLLAVLGVLFVAVAFGAGRLLRPVVPTPEKLLTYECGVDPVGEGWAHTQVRYYVYAFLYVIFAVDSIFLFPWATVFAAAGYGATTLVEMFVFLGFLAVGLLYAYKKGVLEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT43</accession>
    <name>A0A0F4JT43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946472.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2750"/>
    <dbReference type="EnsemblBacteria" id="KJY36984">
        <property type="protein sequence ID" value="KJY36984"/>
        <property type="gene ID" value="VR44_06820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3444"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="35981" checksum="4863A533DE5F2CD2" modified="2015-06-24" version="1">MSEQRPTLAVIAAEAGVSQATVSKVLNGRTDVAASTRERIESLLRSHRYLHPGRPGRARRSGLVDLIIGGLDSAWAVEILRGVEAECARRGVGTVVSLVPPGEATPSSWAALPVLHHSDGVILVTASVTRAQRAQIEQAGVALVVIDPIDLPDNGVPSIGATNWAGGLAATEHLLGLGHRRIAAIGGRKEMLCSQARIDGYRAALERAGIEVDRELIRFGDFQHEGGFRHARELLALPEPPTAVFAGSDQQAMGVYEAARQSGLSVPGDLSVVGFDDLPMCEWLSPPLTTVRQPLEEMGRLAARALFQLLDGQPLVSPRMELSTELKLRLSTAPPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT78</accession>
    <name>A0A0F4JT78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_08430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000174">
        <property type="protein sequence ID" value="KJY36176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36176">
        <property type="protein sequence ID" value="KJY36176"/>
        <property type="gene ID" value="VR44_08430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4586"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7358" checksum="767D2E50DEF1DC14" modified="2015-06-24" version="1" fragment="single">IFAKPTTMPGWLQAFTDYNPLSNLADAARGLMNGTPLGHSVWITLAWSVAITAVLMPLAVRKFRQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTD4</accession>
    <name>A0A0F4JTD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37089">
        <property type="protein sequence ID" value="KJY37089"/>
        <property type="gene ID" value="VR44_06490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3211"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="175" mass="20618" checksum="25D3C68C46C553E0" modified="2015-06-24" version="1">MELPGRHESTRVPEAGRSPRREYCEAVLAEEPPVTPREPYTPQPPAWMDAPVVVFDMSGTPVEWVDEWPLRDYEHRLGQALYELRLEDMRDQLRAEGDAEQSPGNEWARKQERQREKLIASRMQEAINHRAALLSVAERQERGLTAPWNRKPPVSLEKELPEAECYYADWWWERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUX3</accession>
    <name>A0A0F4JUX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946048.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37950">
        <property type="protein sequence ID" value="KJY37950"/>
        <property type="gene ID" value="VR44_04555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.991"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="25458" checksum="5FF5F24421EAA86D" modified="2015-06-24" version="1">MTEAFSVPPAPGPRLAAAVERVVRLGAGLGRSRDEILGPEALHHACGVPLEVVRALLQGRPAGEPDIHERFRQRLDLLHETCRKDNGRKFSHGEIARESGISRQQVQALFGGHRRPTMDHCARLERFFGRPAGFLQSEDAEALSCAVAAVEKTLLQEHRERSERDALAAAPAGAGRRPSLYERHGVDGIALRAALLPDRGRTRLLEWLDHYLDHCMDEGGAEQDPGPAGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW13</accession>
    <name>A0A0F4JW13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000081">
        <property type="protein sequence ID" value="KJY38024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946030.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4251"/>
    <dbReference type="EnsemblBacteria" id="KJY38024">
        <property type="protein sequence ID" value="KJY38024"/>
        <property type="gene ID" value="VR44_04405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="246"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="37401" checksum="638B96B40F7CF420" modified="2015-06-24" version="1" fragment="single">MTDAQETAAHLRTTTGGGPPDEEVSSDGLPIPLLEPREGIPPVVADAEALAEVVAAFAAGTGPVAVDAERASGYRYGQRAYLVQLRREGAGSALIDPVGCPDLSALGEALSGTEWILHAATQDLPCLREIGMAPTTLFDTELAGRLAGFPRVGLGAMVESVLGYQLEKGHSAVDWSTRPLPEPWLRYAALDVELLVDLRDALEKELDRQGKLEWARQEFDAIASAPPAPPRKDPWRRTSGMHKVRRRRQMAVVRELWEARDRIAQRRDVSPGKVLGDAAIVEAALAVPANVHALSALPGYGQRMGRRQLDQWMAAVERAKALPESELPQPGAAPSGPPPPRSWADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWC6</accession>
    <name>A0A0F4JWC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37291">
        <property type="protein sequence ID" value="KJY37291"/>
        <property type="gene ID" value="VR44_06170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2569"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="19807" checksum="AC4E385FE75EBF3E" modified="2015-06-24" version="1" fragment="single">MPDGRTDGSARAFELLEPLVRAATVRVHAAPGGYDSAGTGPTWGSGFFIAPGWVLTCAHVIGEGGAGVRLAGREVGIGFFPGGDTTTSGTVAGRVECVLPERLEERRPGRRALWDLPDLALVRVLSPVTHACVWLTDRARPRLDEAAYFGCTEELGIREITGRTTRLRGLAGGGAAIRLGDEDEIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWN7</accession>
    <name>A0A0F4JWN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_03435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945855.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38545">
        <property type="protein sequence ID" value="KJY38545"/>
        <property type="gene ID" value="VR44_03435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY38545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="47944" checksum="A434BCA5EC16B102" modified="2015-06-24" version="1" fragment="single">MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDKYTGEVRRLGVDVEHDFAPIYVVNADKKAQVRKLKDLLAESDELFLATDEDREGEAIAWHLQEVLKPKVPVHRMVFHEITKDAIRDAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFGTGRAGDASDPSSLVARLNTVDGKRVAQGRDFGPNGQLKGDVLHLDEANARALAAALQGAEFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAARAQVTQLYGADYLPEKPRVYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWS6</accession>
    <name>A0A0F4JWS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_05620</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946247.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2510"/>
    <dbReference type="EnsemblBacteria" id="KJY37416">
        <property type="protein sequence ID" value="KJY37416"/>
        <property type="gene ID" value="VR44_05620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1937"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="13">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="41522" checksum="12C2513102C0457B" modified="2015-06-24" version="1">MTTLPAPLAIGPHTVQPPVVLAPMAGITNAPFRTLCREFSGGKGLFVSEMITTRALVERNEKTMQLIHFDETEKPRSIQLYGVDPVTVGKAVRMIVEEDRADHIDLNFGCPVPKVTRKGGGSALPYKRHLLRAILREAVAGAGDLPVTMKMRKGIDDDHLTYLDAGRIAVEEGVTAIALHGRTTAQHYGGTADWEAIARLKEHVPEIPVLGNGDIWCAEDALRMVRETGCDGVVVGRGCLGRPWLFNDLVAAFEGRPEDFHKPTLREVKRTMLRHAQLLGEWIGDEARGVIDFRKHVAWYLKGFSVGSEMRGKLAVVSSLAELDAHLSELDLDQAWPESADGPRGRTSGNNRVVLPDGWLKDPYDCAGVSEDAELDTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY27</accession>
    <name>A0A0F4JY27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_04690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37906">
        <property type="protein sequence ID" value="KJY37906"/>
        <property type="gene ID" value="VR44_04690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1019"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="900"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1039" mass="106830" checksum="5105E38DFE7B0503" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY74</accession>
    <name>A0A0F4JY74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945542.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39337">
        <property type="protein sequence ID" value="KJY39337"/>
        <property type="gene ID" value="VR44_01780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5760"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7873" checksum="4EF7525341353CEE" modified="2015-06-24" version="1">MTNPSAPKRYLPTSPFKAPVTRPPQQFAVGDQVTHDVYGLGRVIGIEGGIAALVDFGSTQERILSPYAKMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYP9</accession>
    <name>A0A0F4JYP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945998.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38116">
        <property type="protein sequence ID" value="KJY38116"/>
        <property type="gene ID" value="VR44_04250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.141"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="10996" checksum="0F54723CC393464C" modified="2015-06-24" version="1">MRSSSARPHDDPAGDVVRWAAFSCLLVPVVLVVYGTSYGGAAVATLGLAAVTAACRVLLRHSEKTGRAAARVPADEPLAHGHRGRHSRSGSGAHRGCHGSLGPSPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYY2</accession>
    <name>A0A0F4JYY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945436.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4707"/>
    <dbReference type="EnsemblBacteria" id="KJY39587">
        <property type="protein sequence ID" value="KJY39587"/>
        <property type="gene ID" value="VR44_01185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2952"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="33329" checksum="62B412E67B638864" modified="2015-06-24" version="1">MTTIDIDHTSRWFGNVVAVNDVTMRIGPGVTGLLGPNGAGKSTLINMMGGFLAPSTGTVTLDGAPIWRNEQVYRQIGVVPEREAMYDFLTGREFVVANAELHGLDDAAAQRALATVEMEYAQDRKIATYSKGMRQRVKMASALVHEPSVLLLDEPFNGMDPRQRMQLMDLLRRMGDEGRTVLFSSHILEEVEQLASHIEVVVAGRHAASGDFRKIRRLMTDRPHRYLVRSSDDRALAAALIADPSTAGIEVDLKEGALRIQAVDFGRFTELLPQVARAHGIRLLTVSPSDESLESVFSYLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ84</accession>
    <name>A0A0F4JZ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945614.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39139">
        <property type="protein sequence ID" value="KJY39139"/>
        <property type="gene ID" value="VR44_02165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5697"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="432"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="522" mass="54239" checksum="A3EBFFC86403275C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0R1</accession>
    <name>A0A0F4K0R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_01570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4200"/>
    <dbReference type="EnsemblBacteria" id="KJY39513">
        <property type="protein sequence ID" value="KJY39513"/>
        <property type="gene ID" value="VR44_01570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4747"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="375"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="418"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="686" mass="73541" checksum="B22A59220A14C3C2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1Q2</accession>
    <name>A0A0F4I1Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001818">
        <property type="protein sequence ID" value="KJY15920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15920">
        <property type="protein sequence ID" value="KJY15920"/>
        <property type="gene ID" value="VR44_40680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7057"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9277" checksum="D28A2CDCEE4553D2" modified="2015-06-24" version="1" fragment="single">MDGKTLNGWNAAAQLPVLCQDVAAASLRCGEVGPLPPADRPTDNVTTAINGYAVACYAAKLASEQALIYASARGDDTTALAAAGTRAQAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7J1</accession>
    <name>A0A0F4I7J1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001636">
        <property type="protein sequence ID" value="KJY17980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17980">
        <property type="protein sequence ID" value="KJY17980"/>
        <property type="gene ID" value="VR44_39770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6136"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY17980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28250" checksum="849ECAAA1F18A93B" modified="2015-06-24" version="1" fragment="single">GPWADGGMASGMDAAGQDRMARSGLVPFRPQEGLALFDAARTGEQPLAVPVRFDTAAPAAAGPDAGRSVPAVLRGLLRPAARRTVRDAVPGGGPDALRERLARLSGPERDGALLDLVRTHVAAVLGLGGPREVDRDREFKALGFDSLTSVELRNRLNSATGLRLPATLVFDCPTPVALAARIGTDLAPQASPAPSAMSVFGELDRLEQVLATVGADDELVRSRIRTRLHGVLAAFTDAPAPTPGETSDERLRSATVDDIFALIDQELDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEW7</accession>
    <name>A0A0F4IEW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001498">
        <property type="protein sequence ID" value="KJY20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20547">
        <property type="protein sequence ID" value="KJY20547"/>
        <property type="gene ID" value="VR44_38650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5405"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16245" checksum="7E923FE6882707E8" modified="2015-06-24" version="1" fragment="single">SGTNAHVIIEQPPVEPPAPAEERPAPRPVPWLISGGGPEALREQAARLLDHIERHPALEPADVARSLATSRAALEHRAAVLGTLREDFLPALRALAANDPATAGDSAITGTAGSRPGTAFLFSGQGSQRLGMGRELYESFPVFADAFDAVCAHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHC6</accession>
    <name>A0A0F4IHC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001482">
        <property type="protein sequence ID" value="KJY20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20878">
        <property type="protein sequence ID" value="KJY20878"/>
        <property type="gene ID" value="VR44_38530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5357"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18020" checksum="39AD3305CFB31A27" modified="2015-06-24" version="1" fragment="single">VRERLARMVVVGNVGALQGGLPLLPDAHADSGRLEVVLLDPRGVRGWLAAAGHLVARMLPGARPAPACPNPGRTVPAQPAPAHGRGPVAGGALEYFSAERVDIRFGRPQPYELDGDVMSAATRLTAEVEPGALRIWLPPRAPDDAPAERTVRPRTTPAGEPVPRVPDLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR55</accession>
    <name>A0A0F4IR55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001323">
        <property type="protein sequence ID" value="KJY23953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23953">
        <property type="protein sequence ID" value="KJY23953"/>
        <property type="gene ID" value="VR44_36755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15611" checksum="4EF4AFA03E4F6E61" modified="2015-06-24" version="1" fragment="single">MGELDSALENAAVLAEEYAGYDEGAARRRVARRIAADRARAALGTTGADQDRGRTAATAWDDLVLDAACHVRAARCLDDLTWSLAESRDFAELALHTRSWPHGVDSALLFGCLLHLTDRLEAAQFWFQYAAGAGSRTAAQCLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRU1</accession>
    <name>A0A0F4IRU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001236">
        <property type="protein sequence ID" value="KJY24384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24384">
        <property type="protein sequence ID" value="KJY24384"/>
        <property type="gene ID" value="VR44_35565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4226"/>
    <dbReference type="eggNOG" id="ENOG502ZEJI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="10392" checksum="77E7846882D2F6DB" modified="2015-06-24" version="1">MFHEGSRAARLLVALLLLGGVLGMLSGEAGLAAGVVALAAVVAVGAAVLVAACLVRPVPPHRIRTAIRDREQRTAFLPQRDPDASGRSRPRAPGRLVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS32</accession>
    <name>A0A0F4IS32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminobenzoate oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001253">
        <property type="protein sequence ID" value="KJY24293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951826.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001253.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24293">
        <property type="protein sequence ID" value="KJY24293"/>
        <property type="gene ID" value="VR44_35800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4315"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="42490" checksum="BED900A3B71F75D3" modified="2015-06-24" version="1">MSTHELYTTAPDEGVWQVPAAGSARFSWEYDEGRERLLALYQKGKDKQWDGAKRIDWDIEVDPYDPLGTPDEVLTLYGTRHWAKLTEKDKGELRRHYSAWNFSQFLHGEQGAMVCAARIVESVPDLDAKFYSATQTMDEARHAEIFGRFLHEKVGMLYPINDSLQGLLGDTLRDSRWDMPYLGMQVLIEGLALAAFGMIRDTTDKPLPKQILAYVMQDEARHVAFGRMALRDYYRQLTDAERHEREEFVIEGCHLMRDRLRGVEVLENFGVPRREAEELSEQSEFLHLFRKLLFSRIVPCVKDIGLWGERLQRAYLDMGVFDMGDSNLDLLMAQDEEVAEALDRERFAAEERERAEEVEAAIQQGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS62</accession>
    <name>A0A0F4IS62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001157">
        <property type="protein sequence ID" value="KJY24860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951525.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001157.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24860">
        <property type="protein sequence ID" value="KJY24860"/>
        <property type="gene ID" value="VR44_34145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3756"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470355" evidence="2">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7383" checksum="EA3D6D63D5404160" modified="2015-06-24" version="1">MIQTSQPFRVSLLAAAMEAGAVRVAPGTFAASRTPGSGNTEVPPRPQAPTADGRWNTLVRKGKAAAVIVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISQ8</accession>
    <name>A0A0F4ISQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001132">
        <property type="protein sequence ID" value="KJY25027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951436.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001132.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25027">
        <property type="protein sequence ID" value="KJY25027"/>
        <property type="gene ID" value="VR44_33650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3640"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470374" evidence="2">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="63"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="31561" checksum="F66E6CF9ED96A8F7" modified="2015-06-24" version="1">MRTAAALALLPLLALTACGSGGAAPAPAGAPTGSGPADDPVAAVRTVDSVASLLPADVRRTGTLRIGSSIGSPPSAYYPNGQDKPPAGQDIDIADAVAKVLGVKLERQGASFETILPALGSGKYDLGTGNFGVTAERLKTVDFVTYINDGQGFAVKTGNTGLTTRITDLVQLCGLTVGTGAGTTFEKTLTAQQGVCAAAGRKPYEIKVFSDPGAVTTALQQGRIDVVMSTINGLRHQAAQPAARTTFLGEYHRLDVGFAFKKDSPLTPAVQAAVNELIRNGTYAAILKKWGTSASAIDTSQINPAEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISU9</accession>
    <name>A0A0F4ISU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001175">
        <property type="protein sequence ID" value="KJY24734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951575.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001175.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24734">
        <property type="protein sequence ID" value="KJY24734"/>
        <property type="gene ID" value="VR44_34435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3867"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="28001" checksum="95D9E0104C60EE83" modified="2015-06-24" version="1">MSLWVVVPAYDEAGSIGATLAALAAQEDTGFRLVVVDNASTDGTARIVREFARSAPFPVDLVHEPEPGAGTAADTGFRHAVRGGARLLLRTDADCLPARDWTAVARAEFGRGAEMVCGRSVPRRDERPTFAEARLLPALVRLTALYGRWRPAHRDPRFRAPYVLCHGHNLGITAGLYVRCGGAPRERLEEGSEDVTLLNRAREHSAAVVRCERLVVENSLRRLRSWGARRTLLWYWDRRYRPVDTKEVHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITE1</accession>
    <name>A0A0F4ITE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001326">
        <property type="protein sequence ID" value="KJY23941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952020.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001326.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23941">
        <property type="protein sequence ID" value="KJY23941"/>
        <property type="gene ID" value="VR44_36805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4673"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6886" checksum="90C6A956AC306BF7" modified="2015-06-24" version="1">MTPTTLLAADHSDLLRHLLLDMTLKAAIVVAALTALALGMRAIWRRAGRGPHGNPHGRPPSRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITU7</accession>
    <name>A0A0F4ITU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001075">
        <property type="protein sequence ID" value="KJY25425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951229.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001075.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25425">
        <property type="protein sequence ID" value="KJY25425"/>
        <property type="gene ID" value="VR44_32550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3322"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16143" checksum="2B9094AAAB1F61D6" modified="2015-06-24" version="1">MSESAAQPAPPALPVTFRPNRTRAVLLGVGSVMFATITAIALLLENLSPGERVSFVVTAVLLSSVLVLLSRPKVVADEAGVTVVNLTTTRRLEWAQILRVNLRPGDPWVFLDLNDGTSLPALGIQPGIAKARAIGDARALRALAETRGTGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITX9</accession>
    <name>A0A0F4ITX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">VR44_32455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001071">
        <property type="protein sequence ID" value="KJY25457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951214.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001071.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000033_gene6736"/>
    <dbReference type="EnsemblBacteria" id="KJY25457">
        <property type="protein sequence ID" value="KJY25457"/>
        <property type="gene ID" value="VR44_32455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3295"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="48"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="515"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="650" mass="71999" checksum="BFF3D5125BFF56A6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITY2</accession>
    <name>A0A0F4ITY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001281">
        <property type="protein sequence ID" value="KJY24151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951902.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001281.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24151">
        <property type="protein sequence ID" value="KJY24151"/>
        <property type="gene ID" value="VR44_36190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4481"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="32374" checksum="57F59CC6E9D1FC00" modified="2015-06-24" version="1" fragment="single">EGNLDVPPAPREAGREPRPGPVPEPPGRPTVSHLGDRAPTYAAEPGALPAADPAALDFLTPDTVLDGARYGTYTLRAASLRGDSARYRGEARRDFLLTARFGSGDDALVLVVLAGGDRAAPGAREAAAELGHSVAAAVGRSRERLAEDIRAGRREALLSGLQRLTDRGYGRLRARAAELGLDQEAYTAGLRGLLLPLDPQCPHRICFGAGPGGIFRLRSGRWQDLEEGTGGATGFRFRASAARPGDTLLLCSAGLADPMREEGLLPAELADRWSQGEPPGLAAFLADTQLRVKGYADDRTAAAVWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUG0</accession>
    <name>A0A0F4IUG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001041">
        <property type="protein sequence ID" value="KJY25650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951119.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25650">
        <property type="protein sequence ID" value="KJY25650"/>
        <property type="gene ID" value="VR44_31945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3104"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="32309" checksum="47F1061415720F21" modified="2015-06-24" version="1" fragment="single">GWDRAGARTGAALGFDTAVLVDAVDRQGGIETLAGPGTPVLVVTEPTETATAAAFAHTAVLAGRPGNAAPLAEAGRYFGRLAHLLDAVEDQTADAAAGAWNPLTATGTSRAEARRLCDDALHGIKLAMREVEFADAGLAHRLLVHELRTSVDRAFGTTSCGHGHAAANSAGQGYGQPPQASPPHGYDPNAQGGYGQGGPYGGTPYGQNPYGGGAPQYAPGGPGMPPPMGPGGPGGGGGHGGGGLPPQKPRRGLLHGCAVAIGLFCTCQICCTDYEGPWSRKKRDAWCDDCDCDCCNCDGCDCCNCDGCCCDGCDCDCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUJ6</accession>
    <name>A0A0F4IUJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_32825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001093">
        <property type="protein sequence ID" value="KJY25314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951278.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001093.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25314">
        <property type="protein sequence ID" value="KJY25314"/>
        <property type="gene ID" value="VR44_32825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3381"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="4">
        <location>
            <begin position="148"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="5">
        <location>
            <begin position="152"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34986" checksum="DCBB9956B6ACBA33" modified="2015-06-24" version="1">MLQLPGGPLLLSAPSRPGAESSDRWTLAVRTSRDEGRTWSKEGAVVLRERAGYSDMAALPGGRVGLVYETANGTPHGYVKFTAFGPHELQAAAEDLTPRRTSDTTPYRNHAVVHGNPRLGNRPGGGRSMRFDGKDDFLRLTDCPDELRVGAGDFAIATWVKYKTRGQDRESGTRQPLVWAYGQGPTAPQIRIEADPATGRLEGTVNSGTGPVSVTSRSRTDDDTWHHVVLQRSGDRLELSVDGTPPTTTATPTGPAGDLRPTGPFTIHLGTQPDYKAFYAGALDDVRVYGRALSRNDMARLRDGNDVTDQERVHLPFDRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVS0</accession>
    <name>A0A0F4IVS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001058">
        <property type="protein sequence ID" value="KJY25553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951168.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25553">
        <property type="protein sequence ID" value="KJY25553"/>
        <property type="gene ID" value="VR44_32200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3161"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="424" mass="42111" checksum="7FC784B0B63DE5DF" modified="2015-06-24" version="1">MSARAHAAPSPTPPPSGSPSGSPSGTPAPSKCEGVIGTLKEACERQAGGATPGTGAGTGLSPNSPTDALNPLASLARGCADAAAWIVGKLSEAVKGTANVDFTNPAFLQQYAVVFAASTVLTLVLWLLAVAKRAIRGVPLSTALSEAIGFLWLTVLASAFTPLILYTVVSATDGVTDVIASATGSQSDVFFGSFTDALKKGDDIGGGPIMLIVVALVTVLAAGVLWLELVIRAALLYVGALLGTVVYAGLVDRNMWGHVRRWAGIMIAVILVKPVIVIVLGLAGALAGNKGPNAFSAVVSGLAIILLAIFASAMIYRFVPGFGDEIASARSNRKQATDGAQAAAVISSPASLVSQGIKTHSSRGGAHRAGGGGSTGGDANQISGGMAAHSSRGSGSGTGGGSVPPAAPPPRTGSSTRNTGGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVW1</accession>
    <name>A0A0F4IVW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001163">
        <property type="protein sequence ID" value="KJY24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24831">
        <property type="protein sequence ID" value="KJY24831"/>
        <property type="gene ID" value="VR44_34220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3815"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12382" checksum="D540D0DAAD0E77CC" modified="2015-06-24" version="1" fragment="single">SWGAVVIREPSTVAYLCDIFDQTWDLASPFSAAAGQGLEEVAREIHETIIRLLAAGLKDEAIARRLGMSLRTARRHIADIMQELGAGSRFQAGVAAAARGLLDLEGQIDGEPVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW63</accession>
    <name>A0A0F4IW63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001033">
        <property type="protein sequence ID" value="KJY25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951096.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25698">
        <property type="protein sequence ID" value="KJY25698"/>
        <property type="gene ID" value="VR44_31830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3078"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="6"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="423" mass="44710" checksum="72354DEBA350ED28" modified="2015-06-24" version="1">MTGRRVAVTGVGVVAPGGIGAPAFWDLLSNGRTATRGITLFDPDGFRSRIAAEVDFDPTEHGFTEDEAARADRYIQFALVAAREAVADSGLELDGESAWRTGVSLGTAVGGTTRLEHDYVDVSQRGAWWDVDHRLSSPFLHRAFTPATLASAVAEQTGARGPVQTVSTGCTSGLDAVGYAVHSIQEGRMDVCIAGASDSPVSPITVACFDAIKATSANNEDPAHASRPFDADRDGFVLGEGGAVLVLEELERARARGARIYCEIGGYATFGNAHHMTGLTAEGLEMARAIETALAQARVDAREIDYVNAHGSGTKQNDRHETAAVKRVLGDHAYRTPMTSIKSMVGHSLGAIGAIELAACVLAMTHHVVPPTANYETPDPECDLDYVPRTARKHTLRNVLSVGSGFGGFQSAVVLTQPKEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWN4</accession>
    <name>A0A0F4IWN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001014">
        <property type="protein sequence ID" value="KJY25883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951001.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25883">
        <property type="protein sequence ID" value="KJY25883"/>
        <property type="gene ID" value="VR44_31330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2754"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="37553" checksum="A1B5FE01A06952F6" modified="2015-06-24" version="1">MKTEDHTVQIGTEGCTGLITLNRPEAINALTHPMVLRIGEALTAWEHDPAVRQVLLRGAGERGLCAGGDIRAIHADAKAGTTGSLAFWRDEYRLNARIARYPKPYIALMDGIVMGGGVGLSAHGSVRIVTERSRVAMPETGIGFVPDVGGTYLLSRAPGELGTHLALTGTAVGPGDAVLCGLADHYLPSDWLEEFTRELTFAPVDEVLGKFDGATAPAVPLAAEREWIDHCYAADTVEEIHQRLLATGLPAAREASQTLHAKSPTSLKVTLAALRRARALDSLERVLEQEYRVSSAALSSAPDLVEGIRAQVIDKDRRPRWNPAALVQVRAASVERFFAPLGEGSELTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWT3</accession>
    <name>A0A0F4IWT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000936">
        <property type="protein sequence ID" value="KJY26467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950759.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000936.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26467">
        <property type="protein sequence ID" value="KJY26467"/>
        <property type="gene ID" value="VR44_29980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2378"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470490" evidence="3">
        <location>
            <begin position="27"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="130"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="5">
        <location>
            <begin position="443"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="546" mass="56342" checksum="1CAFB558916A7BD2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXM7</accession>
    <name>A0A0F4IXM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000971">
        <property type="protein sequence ID" value="KJY26213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26213">
        <property type="protein sequence ID" value="KJY26213"/>
        <property type="gene ID" value="VR44_30660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2586"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="15628" checksum="E8C9F8528AA16646" modified="2015-06-24" version="1">MYGTVLASGLLAALDQKGGEYTPFYDASWVLVTAATAGLAHGYSHHMTTHRSGSAAHRWRLLVRALWNEWPMIAATLPTVLLLVAAGIAHWESYGVTAVGLGLNTALLFAWGSFVAIRVGYRIGSALLIGLADATIGLAIIVANALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYQ9</accession>
    <name>A0A0F4IYQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000903">
        <property type="protein sequence ID" value="KJY26799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950612.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000903.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26799">
        <property type="protein sequence ID" value="KJY26799"/>
        <property type="gene ID" value="VR44_29175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2179"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="11662" checksum="4088256CBD0C2E9F" modified="2015-06-24" version="1">MRCYWDEEDTWFYFEVDAEGWVIRQVELEGPELIPIAAASLAEWQRARDAGRLGDYDSRFGITAELPVPEWEGHDPEQLTFEEFEDVWGPARQQIASRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYW0</accession>
    <name>A0A0F4IYW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950426.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000858.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2558"/>
    <dbReference type="EnsemblBacteria" id="KJY27210">
        <property type="protein sequence ID" value="KJY27210"/>
        <property type="gene ID" value="VR44_28155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1875"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="29113" checksum="415600605238D544" modified="2015-06-24" version="1">MSRHVAIVTDSTAYLPPPAMERHGITAVPLTVVLGDEALEEGTEISARSLAAALQKRRPVTTSRPGPEQFVRAYRAAAEAGATGIVSLHLSAEFSGTHDAAVVAAKTAPVPVRVVDTGMVAMALGFCALAAAETAEAGGSVDEAVAAAEKRAGEMSAYFYVDTLDYLRRGGRIGAAQALLGSALAVKPLLTLEGGRIEMLEKVRTASRAIARLEELAVERAGTRSVDVAVHHLAAPERAEKLAQRLGERIPGLVELHVSEVGAVIGAHTGPGLLAAVVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ05</accession>
    <name>A0A0F4IZ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000854">
        <property type="protein sequence ID" value="KJY27255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950399.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000854.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27255">
        <property type="protein sequence ID" value="KJY27255"/>
        <property type="gene ID" value="VR44_28010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1853"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25066" checksum="A5082DE345840BFF" modified="2015-06-24" version="1">MRFLRFVVIVAVVLGGLFVGADRWAVGYAENRLAEKIQSRQGLAGGVEVDIHGFPFLTQALSHELEQVDLKLTDVDVTADGRKTRLSQLDAAFHDVKLNSSYTGGSAKRAEGTALISYADLTKASQTGATLTYGGQPGKLKVTASVDFLGRTLTRSVISTVELVDGKAGSGGGKTVRVHADSVPGEGIPGIESAIRKRTDFDRRIDDGLPAGLKLSALTSDEAGVHLTLTGTDVSLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ33</accession>
    <name>A0A0F4IZ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000887">
        <property type="protein sequence ID" value="KJY26914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26914">
        <property type="protein sequence ID" value="KJY26914"/>
        <property type="gene ID" value="VR44_28910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2122"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9520" checksum="6F44756B3324B78C" modified="2015-06-24" version="1">MTSSLGPPSREDQGTPTTTSSCPLQEVSTAVKAASTTATGVAPVRRATSSRRRASAPPTVESTAPPSKVVTAGRRARKGSPWVRGASPSRSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZY0</accession>
    <name>A0A0F4IZY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27209">
        <property type="protein sequence ID" value="KJY27209"/>
        <property type="gene ID" value="VR44_28150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1874"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="19132" checksum="1C9EF93A13FB4114" modified="2015-06-24" version="1">MPVWVQARCGVEPRAVAAVGVVLALAVGFAAQQYWSARPQPVTAPAVLAPAPPATPPPVPGGGPGGSGGRIGSRVEDALAAAGGVRPGTDTSGLNRARVLVDGEQVLVGVTAPPAPGGPGSVGGSGPGSVPLSLGSATAEQLDGLPGVGPVLARHIVEFRTARGGFRAVEDLRQVDGIGERRFAELRKLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0E3</accession>
    <name>A0A0F4J0E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000801">
        <property type="protein sequence ID" value="KJY27740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950191.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000801.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3160"/>
    <dbReference type="EnsemblBacteria" id="KJY27740">
        <property type="protein sequence ID" value="KJY27740"/>
        <property type="gene ID" value="VR44_26860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1531"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23434" checksum="9C02D514F44B55AE" modified="2015-06-24" version="1">MDSTAETTDGYQAWSEVTPDAARRLLVAAVEAFAERGYHATTTRDIAGRAGMSPAALYIHYKTKEELLHRISRIGHDKALEILETAASAPAAAAERLDAAVRSFVRWHAAHHTTARVVQYELDALAPEHRSEIVALRRRSDAAVRRILSEGVRAGEFDVPDVPGTTLAVLSLCIDVARWFNVDGRRTPDEVGALYADLVLRMVGARPAAGTAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1S3</accession>
    <name>A0A0F4J1S3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_26705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000794">
        <property type="protein sequence ID" value="KJY27819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27819">
        <property type="protein sequence ID" value="KJY27819"/>
        <property type="gene ID" value="VR44_26705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1500"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="336"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="955" mass="99118" checksum="25491E325A892CBD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J474</accession>
    <name>A0A0F4J474_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_24970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5956"/>
    <dbReference type="EnsemblBacteria" id="KJY28614">
        <property type="protein sequence ID" value="KJY28614"/>
        <property type="gene ID" value="VR44_24970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1082"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="36094" checksum="40DEED93DF8786FD" modified="2015-06-24" version="1">MAESPPETEPGAPESGAPAPAVARPGHGRRAAGLLIVLAALALVAVASIAVGAKAMPLADVWHGLFHYSGTTNDVVVRDLRVPRTVLGVMVGLGLGLSGAVMQALTRNPLAEPGILGVNAGAAAAVVSAISFLGASTLTEFVWWAFLGAAVVSAAVYVLGGSRSATPVRLALAGTAASAALVGYINAVQLMDSKALDKLRFWTVGSLASATMDTVRQVAPFLLAGALLALVLGRPLNAMAMGDDTARALGAHLTRTRITAMAAITLLCGAATAACGPIVFVGLMIPHLARLVTGPDMRWVLAYSAVLSPVLLLGADVIGRVVTRPAELQVGIVTALIGGPVFIYLVRRKRMAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4U4</accession>
    <name>A0A0F4J4U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal resistance protein CzcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000646">
        <property type="protein sequence ID" value="KJY29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29392">
        <property type="protein sequence ID" value="KJY29392"/>
        <property type="gene ID" value="VR44_23065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.552"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="42704" checksum="7F750C8E6D7B65FF" modified="2015-06-24" version="1">MAAELGYHQSKISRLEGGRGTDDIRVLREVARVLRIQPARLGLADAGPEAEPHDPETDDMRRRTFLAAGVTALAAPVPAAHPALVQALLPGVLAAPTTEPASTDRLRLRATSIRRLLTTCDYAELERTLPSLITDLRHALGSSSQPEEVSRFLATAYQTSASLFLKQGDAGTAWLAVGRAMAEAERFGDPLVLAASVRLHAHVLVREKHPGQAVTLIRHTASQLTGSYDRRSPHHLAVLGLLLLRGATAASRADDRAATGELLAEAEEVARYVALDRPDAWANFSPTNVTLHRISAAVSFGDAGIALDAARPLMHRHIPVPERRAALWIEAARAYAQQGRLADGYQALRIAETCAAQDVRRPAVRELVADMAARDRRRTLPELHHFSRRLGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5B8</accession>
    <name>A0A0F4J5B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_22660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949414.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29542">
        <property type="protein sequence ID" value="KJY29542"/>
        <property type="gene ID" value="VR44_22660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.464"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="37"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="309"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY29542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="41865" checksum="78188AED2CAC013F" modified="2015-06-24" version="1">MTPRAPAPARLRPPRLGPRDVLHVGSAGLRSRPVRVFLSALGIAIGIATMIAVVGVSSSSQAKLLEELEKLGTNMLVVTPGQSMFAGQDTKLPKEAPGMLSRIEGVESVGTTGDVAESVRRSEKIPKEETGGIAVKAAKDDLPGVLRARMRSGVWLNEATSRYPAVVLGHVTAERLGIGGPGGQVFIGGRYFTVIGVLDPVPLAPEIERSALIGWQAAEDLLGFDGHPTAVYERSADDRVAQVRALIARTANPQSPTTVSVTDPSAALQAKAATEGAFSTLLLGLGGIALLVGGVGVANTMIISVLERRHEIGLRRSLGATRGQIRVQFVTESLLLSGLGGLAGIALGAAATWVYARTGDLPWVVPLWAVTGGFAATLTIGTLAGLYPAVRAARLSPTLALQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5P5</accession>
    <name>A0A0F4J5P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_23620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000668">
        <property type="protein sequence ID" value="KJY29159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29159">
        <property type="protein sequence ID" value="KJY29159"/>
        <property type="gene ID" value="VR44_23620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.669"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="481" mass="48939" checksum="2DAB2411EB2DFB40" modified="2015-06-24" version="1">MSSTPARPSFGTVILAVSLPMFMVALDNLMVTNALTSIRADLGASVEDLQWITNAYILGFAGLLLAAAALGDRFGRKRVFVTGIAVFALTSVGGALSSSTEALVLFRALQGMSAAAVMPLSLTLLAMAVPAEKRGAAIGLWSGISGLAVALSPLIGGAITSGLDWQWIFWVNVPVAVVAVPLVLKAVSESRGAPVKLDLLGLVLACAGVVSLVWAIVNGHEKGWGSAPVVSAFAAAVVLLGAFIAWERKAAAPLLPLSFYRVRAFTLSNVVSLAVYFGMFGATFLIAQYLQTGLGHSAFVAGLWTLPWAVMPMFIAPQAGKLAAKVGAGRLMALGLAVSGVGLAWFALVVGVGISDWAFVGPFVLAGAGMGLVFAPTATVVMGAVPPQHMGKASGANTTVRELGGAFGIAVLASVFAAQGDFSGQQRFVDGLVPAVWIAVAVVFVGALFALAIPRPKAAPAPAAAPASPAPQVKQPADATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J651</accession>
    <name>A0A0F4J651_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000611">
        <property type="protein sequence ID" value="KJY29837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949278.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000611.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29837">
        <property type="protein sequence ID" value="KJY29837"/>
        <property type="gene ID" value="VR44_21925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.265"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7994" checksum="C2705561115623C4" modified="2015-06-24" version="1">MPKTQPVNDGKGSEADDPPETAAQRRARRAQFLRDLMEARALRDRVQPRRARAARMRQQMRMRTFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6S2</accession>
    <name>A0A0F4J6S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29453">
        <property type="protein sequence ID" value="KJY29453"/>
        <property type="gene ID" value="VR44_22865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.507"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17259" checksum="6A47B6E0B064783D" modified="2015-06-24" version="1">MWAVTEHKNHRYAVAVTRRDDRWHCTRLDRTALTGLDEAIIAVRGDGTSGTVYGFFNADEAFFLVLRSTPAGTGLLLSDARAVHRHTLAAQVLDVLGTEAPDEDAPGPQPAGDLGIVADLGLSATGMQAVLDRPGALPHDQLLTIAERCGFAAEFERVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W2</accession>
    <name>A0A0F4J6W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949131.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000589.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5044"/>
    <dbReference type="EnsemblBacteria" id="KJY30107">
        <property type="protein sequence ID" value="KJY30107"/>
        <property type="gene ID" value="VR44_21185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8960"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470176" evidence="1">
        <location>
            <begin position="28"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="424" mass="44560" checksum="E6C9B324D318AFCA" modified="2015-06-24" version="1">MRRGIAATALVATLALAATACGGDTKGDGGETKAGGELSGTVTWWDTSNDAEKASFQKIAEAFTAKHPKVTVKYVNVPYGDAQNKVKNAFSSGADAPDVIRADVGWVADLASLGYLDEVPADQAKKVDAEFLPQAAASGKFDGKTYAVPQVIDTLGLFYNKKMLADAGVQPPKTLEELKTAAAAIKAKSGKTGLYLRGDDSYWFLPFIYGEGGDLVDAKTKTVTVDNAAGVKGFKAARDLVTSGAAVTNATDGWTNMQTAFKSGEVAMMINGPWAVADSYAGEQFKDKSNLGVAAVPAGSVKAGAPQGGHDLAVYAGSKNTAAAHAFVEYMTSQEVQVQSAKELSLLPTRTAAYEQPDVKNSEMVQFFKPAVDKAVERAWIPENGSLFEPLKVEYTKAVTGTSSPEDAAKAAGAEFRKILKGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7D4</accession>
    <name>A0A0F4J7D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000698">
        <property type="protein sequence ID" value="KJY28851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949730.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28851">
        <property type="protein sequence ID" value="KJY28851"/>
        <property type="gene ID" value="VR44_24385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.864"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14446" checksum="D9FDD569626E023D" modified="2015-06-24" version="1">MRALVYDNAFRGRARRRQAWGFCLLAASAGIWLWIAAQLVLPYSVTGGDDSKCQSRVFYTKETDRGRPYEGYADAEGTRCTAERDWAGLLALLLLSLPTAVVGTVLYTSGSTGHRLSEHAAEVNRLKEFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J856</accession>
    <name>A0A0F4J856_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949208.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29964">
        <property type="protein sequence ID" value="KJY29964"/>
        <property type="gene ID" value="VR44_21480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.174"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470471" evidence="3">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="20535" checksum="75F0912EF6617309" modified="2015-06-24" version="1">MAAAALTLTVAATALTACGTAAATKPPPAPEVGSTATTAAPPTAPPLARSKPTGMKIDAAGVDAKRMVDLKVDPSTGELGVPDPDTGANDPGWWTGGATPGEKGVSVLVAHFDTKHGPALMRNVANIRLGDLIEVPREDGQTAKFKIREIEDVPKEDFPTAKVYPDTPRPELRLLTCGGEIKNGHRTNNVILYADLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J885</accession>
    <name>A0A0F4J885_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY29999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949183.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29999">
        <property type="protein sequence ID" value="KJY29999"/>
        <property type="gene ID" value="VR44_21450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.167"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14176" checksum="BA2B67F4B1A39184" modified="2015-06-24" version="1">MTTAREIMTPDATCIGADDSILDAAKKMTDLGVGALPICGSDQLLKGMLTDRDIVVKVLGAGKDPATCRAGELAQGEAVTIGADDDASEILRTMAEHKVRRLPVIDGHTLVGVVAQADVARALPDPQVGELLEALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8F9</accession>
    <name>A0A0F4J8F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949165.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30074">
        <property type="protein sequence ID" value="KJY30074"/>
        <property type="gene ID" value="VR44_21335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8992"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470480" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10350" checksum="AEA6D857EDAA18FE" modified="2015-06-24" version="1">MTFTKMTDRSVAASCLLGSVSLRGTGLSAISADKPALLATLPVSERNERPTKALVAVAGAQQAHGAYGPAAAAGAGFKQTTTQHHLMWAFRGLEPWSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8H5</accession>
    <name>A0A0F4J8H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">VR44_20315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948988.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6981"/>
    <dbReference type="EnsemblBacteria" id="KJY30490">
        <property type="protein sequence ID" value="KJY30490"/>
        <property type="gene ID" value="VR44_20315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8772"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24700" checksum="A51F9D7B618AD11B" modified="2015-06-24" version="1">MLPESWLPVLGGELDQPYFKELTEFVDKERANGPVYPPREQVFAALEATPFDKVKVLVLGQDPYHGAGQGHGLCFSVQPGVKTPPSLRNIYKEMKEELGLEIPDNGYLMPWAQQGVLLLNAVLTVREAEPNSHKGKGWEKFTDAVIRAVSDRPDPSVFVLWGAYAQKKIPLIDQERHVIVKGAHPSPLSAKKFFGSRPFTQINEAVAAQGHEPIDWRIPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Q8</accession>
    <name>A0A0F4J8Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000538">
        <property type="protein sequence ID" value="KJY30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30777">
        <property type="protein sequence ID" value="KJY30777"/>
        <property type="gene ID" value="VR44_19530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8516"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11295" checksum="E1304D15C5050615" modified="2015-06-24" version="1" fragment="single">VLAHATTGRFPFGEGPPEVLAYRASHGKAELHGLPADLAEAVAAALAPVPGDRPTAVELSRTSALRRTTSVADGPAPGKVIIALAALAQETADLGGGADRHLSRRTDVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8V2</accession>
    <name>A0A0F4J8V2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gvpA</name>
        <name evidence="7" type="ORF">VR44_20940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949089.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30234">
        <property type="protein sequence ID" value="KJY30234"/>
        <property type="gene ID" value="VR44_20940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8918"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18655" checksum="DA85C94FB3CEF594" modified="2015-06-24" version="1">MTMMPQGAGTAVRGDNRGGSTSSLYDVLELILDRGLVIDVFVRVSLVGIELVKIDARIVVASVDTYLRFAEACNRLDLEAGRKAPAQLPEVVGDMLEGGGRGKAKGALGGAIDAVKESLTGGDRDEDEDEDEDEEPEEWEEPEDEEREEEEQPVRRRRTARRAARRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9V5</accession>
    <name>A0A0F4J9V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948937.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1591"/>
    <dbReference type="EnsemblBacteria" id="KJY30584">
        <property type="protein sequence ID" value="KJY30584"/>
        <property type="gene ID" value="VR44_20110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8646"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="13"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="39259" checksum="3841DCF2C734B771" modified="2015-06-24" version="1">METELSKKLGVEHAIFGFTPFPAVAAAITRAGGFGVLGAVRYTAPDDLKRDLDWMQAHTDGKPYGLDVVMPAKKAVDGISEADIEAMIPAAHRAFVRDTLAKHQVPELAEGEASGWRITGWMEQVARSQLDVAFDYPIKLLANALGSPPADVIARAHDHGVLVAALAGSAKHARRHAAAGIDIVVAQGYEAGGHTGDIATMVLVPEIAEAVAPLPVLAAGGIGSGEQIAAGLALGAQGVWLGSLWLTTTEAELHSRALTEKLLAAGSGDTVRSRALTGKPARQLRTEWTDAWDDPAGPGALPMPLQGLLVAEAVSRIQKYEVRPLLGTPVGQIVGRMNSERSVQAVFDELTSGFERAIDRIDRIAGRQPREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAM3</accession>
    <name>A0A0F4JAM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948650.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31245">
        <property type="protein sequence ID" value="KJY31245"/>
        <property type="gene ID" value="VR44_18560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="534" mass="54800" checksum="69EC17521685B304" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAY8</accession>
    <name>A0A0F4JAY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948780.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30949">
        <property type="protein sequence ID" value="KJY30949"/>
        <property type="gene ID" value="VR44_19245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8455"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="471" mass="50523" checksum="757EBAB43FD8BDC4" modified="2015-06-24" version="1">MTDSWATYGADLHLDLSSVAAGERGLRAALTGSLREAARSGRLAPGTRLPSSRTFAADLGIARNTVAEAYAELVAEGWLTARQGSGTRVAERARPRHTPAPPRVRRPARRGPAYSLVPGSPDVGAFPRTAWLAAARRALTDAPNDAFGYGADTRGRIELREALSGYLARARGVYADPDRIVLCAGFVHAARLLGQVLRGRRIREMAVEGYSLDLHRNLFTDAGLRTRPLWVDGSGARTPDLAGLGPRVGAVLLTPAHQFPTGAALTAERRAAAVDWARTTGGLVVEDDYDGEFRYDRQPVGALQGLDPDRVVYLGTASKSLAPGLRIGWMVVPPDLLDEVMAAKGPAEWTSSALEQLTLAEFLTSGAYDRHVRAMRLRYRRRRDELVAALGGRVPVSGIAAGLHAVLDLPSGTERSVVRAAAWQGLAVEGLERYRHPDTEMPMREALVVGYGTPADSAWTPTLEALTAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC21</accession>
    <name>A0A0F4JC21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uroporphyrin-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_18350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000063_gene1477"/>
    <dbReference type="EnsemblBacteria" id="KJY31359">
        <property type="protein sequence ID" value="KJY31359"/>
        <property type="gene ID" value="VR44_18350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8219"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="7">
        <location>
            <begin position="210"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="50025" checksum="B299DB82622E6E1F" modified="2015-06-24" version="1" fragment="single">GVPVIRDAANLVMEAARSGRRVVRAVTGDPGLDGNAAAEMLACANEGIPFEVVPGVATAVGVPAYAGVPLRGDKGADVRFVDAKHASARCWAEVGAGEGSVVVVSATLETVAAAAAELVSAGRKPETPLTVTVGGTTTRQRTWTATLGTIAQVFKQGKVLPSPEGSRPVIAVVGEQGAATRREELAWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAAALVEFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPADTREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVGKLAEALAAYGEARREAAKEAGEAVARPSERRPGARRRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC55</accession>
    <name>A0A0F4JC55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000500">
        <property type="protein sequence ID" value="KJY31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948623.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31333">
        <property type="protein sequence ID" value="KJY31333"/>
        <property type="gene ID" value="VR44_18430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8236"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23591" checksum="E26AD497FD893E28" modified="2015-06-24" version="1">MVYQLVIFDNDGVLVDSEPISNTILATYLTEVGHPTTYEDSLRDYMGGAVHRVHDLVHERTGQRLPEDFDRILHERIFAAFASELHPVPGVTDVLGELSARGVPYCVASSSSHERIRVAHRAAGLDEWFEEEWIFSAEEVALGKPAPDLFLHAADMMGVHPSQCVVVEDSPLGIEAARAAGMDVLGFTSMVPASKLTGATACFGEMKELPALLGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC69</accession>
    <name>A0A0F4JC69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="1">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948947.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000555.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30566">
        <property type="protein sequence ID" value="KJY30566"/>
        <property type="gene ID" value="VR44_20115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8727"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="20021" checksum="061D0A195C5B69BC" modified="2015-06-24" version="1">MESTERPRGPHLEWTVLPSEIGPLLLAATPEGLVRVEFHAGPDRAGRMIGALVSRLGAEAWRPEPGREVLLAEPIRQLKAYFAGTLRRFDLPLDWRLSSGFNRQVLLELDRSVPYGSVVGYGELAARVGQPGAAQAVGNAMGSNPLPLVVACHRVVENDGGIGGFGGGVETKRTLLALEGVLPQPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCI4</accession>
    <name>A0A0F4JCI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32062">
        <property type="protein sequence ID" value="KJY32062"/>
        <property type="gene ID" value="VR44_16825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7800"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="30288" checksum="61EC555458314BAB" modified="2015-06-24" version="1">MGLTIAPLPVPRSGAALRAAFLEAVVLAGHVLLYPSGVREERREGRAGRAGDRAGAGQLPPVLLLHGFTDNRSVFVLLRRALGAGGLRRVETYNYSPLTLDLRVTARHLARRVEELCERSGQDRVDLVGHSLGGLVGRYYVQRLGGDARVRTLVTLGTPHGGTRVAPFMDAHPLVRQMRPDSPVMAELRAPAPGCRTRCVAFWSEFDALMAPTGTARIDHPDLDATNVEVTGIGHLALPVHPAVITAVRRALDGPVRDAQGAGVAEGAVRKLRPAGTEGEGMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDE4</accession>
    <name>A0A0F4JDE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_16370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000428">
        <property type="protein sequence ID" value="KJY32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32225">
        <property type="protein sequence ID" value="KJY32225"/>
        <property type="gene ID" value="VR44_16370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7731"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="436" mass="44899" checksum="A9C8033A286C766B" modified="2015-06-24" version="1">MLGLLPRRAQALLAANAVNSFGAGLVMPFLLVYFGDVRGLDIRTGPAAIAITGLCSFCSGLVWGHLLDKFSYRIVMPVVMVIAGVGTSLYAVADRPWTALAVAALYGLGMGGVGTVTKTMFATVVPKEHRTLTFGLEFTLFNAFVGIGVLVGGLVAAGTLRSYQLLYVGDGLSFLITAVAFLVLLPKSAQPSRPQAAGDPDAPKPSYRTVLATPALALALLGMLLCATVSLSQFQSALPGYVTVNGAVTPRGISVAFVANVVVIVLAQFLLMPRLTKVRRSTLISASGVLSAASWACVYFAGLTSGTAAVVTLVAGVAIFSVAEVIVIPVVAALINGLVTDEVRGRTNALFSFVISGGMILGPLLTTALLDVDHGRVLIVVLAIGSLLVPLAGLRLRRSLTDEHDLPEAKAEAGSEAENATGTEAAPQGEPAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDH9</accession>
    <name>A0A0F4JDH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000423">
        <property type="protein sequence ID" value="KJY32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32260">
        <property type="protein sequence ID" value="KJY32260"/>
        <property type="gene ID" value="VR44_16255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7704"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35336" checksum="DB6677096F2479A0" modified="2015-06-24" version="1" fragment="single">RMHRVAIVAQPGIRAFDLAVITEVWGPDRSRSGVPPFELRRCALEPGPIALPGGLTLAPDRGLDWLDEADLVVVPALAEPSDPTPEPVLAALRRVHARGVPVAALCAGAFVLAEAGLLDGRRAVTHWWLAPQLAARYPAVLVEEAPLFVEDDGLWTSAGVASGIDLCLHLVREAHGAEAAAAVARSMVTGPFRTGDHAQYLDRPTPAADRTAEALAAVRQQALRRLHEPLDVATLARWAGMSPRSFARHFAASTGTTPHRWLLSRRLDEARKLLERTDHPVPEVARRAGFASEVSFRQHFGAAFGRSPRAYRTAAANAPIAGDSVRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDM2</accession>
    <name>A0A0F4JDM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_18995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948732.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31061">
        <property type="protein sequence ID" value="KJY31061"/>
        <property type="gene ID" value="VR44_18995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8403"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="426"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY31061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="538" mass="56710" checksum="17F89B378DA58AF4" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE08</accession>
    <name>A0A0F4JE08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000509">
        <property type="protein sequence ID" value="KJY31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948657.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000509.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4154"/>
    <dbReference type="EnsemblBacteria" id="KJY31226">
        <property type="protein sequence ID" value="KJY31226"/>
        <property type="gene ID" value="VR44_18595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8315"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="34530" checksum="3900AF6FE766BB36" modified="2015-06-24" version="1">MPPKIDIDVYVKGVLDGKRAHIARAITLVESTRADHRTLAQRLLTELLPHSGKARRIGISGVPGVGKSTFIDAFGTMLTGLGHRVAVLAVDPSSTRTGGSILGDKTRMERLAVDPSAFVRPSPSAGTLGGVAKATRESMIVMEAAGYDVVLVETVGVGQSETTVAGMVDSFLLLSLARTGDQLQGIKKGVLELADVLAVNKADGPHARDAKAAARELSGALRLMHPADAAWTPPVLTCSARESTGLDELWNRLEQHRTVLETGGRLAAKRAAQQVEWTWSMVRDELLERLKADPAVRDLAPALEAGVRAGTVTATSAADRILAAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEI8</accession>
    <name>A0A0F4JEI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948590.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31396">
        <property type="protein sequence ID" value="KJY31396"/>
        <property type="gene ID" value="VR44_18265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8200"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16420" checksum="396687A63FBA3C9B" modified="2015-06-24" version="1">MVRMTPPEIDDIHRLRVMAAGVRGATVVERTLPAPFEEVWPLMSALDFLPDLRHTRLLHSDGDRIELLARSKYGFRAHLRGFRRPGWCWLQSRFLLVGLAAAPVPGGTRIALTGGVRIPTRAAVLPFGTHPELTTATTRLASRVTGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEZ8</accession>
    <name>A0A0F4JEZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000415">
        <property type="protein sequence ID" value="KJY32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32384">
        <property type="protein sequence ID" value="KJY32384"/>
        <property type="gene ID" value="VR44_16105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7644"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="22193" checksum="818325506CFE3A5D" modified="2015-06-24" version="1" fragment="single">SWNGFASEPVGSADSGRVALSADGSAIVWTQAGQVPYRSTDKGASWSRVSGLGADAVVVSDRSSATAFYSLSGGTLYASTDGGATFTARATGLPDGRLKAVPGVAGDLWIAGGSKGLLHSTDGGRTFTTLTTVRSASALGFGKAAPGGSYQALYLIGTVKDVTGVFRSTDKGATWLRVNDDAHQWGGIGSVGVITGDPDTYGRVYIGTNGRGLQYGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFK0</accession>
    <name>A0A0F4JFK0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_14855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000380">
        <property type="protein sequence ID" value="KJY32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947952.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000380.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2587"/>
    <dbReference type="EnsemblBacteria" id="KJY32965">
        <property type="protein sequence ID" value="KJY32965"/>
        <property type="gene ID" value="VR44_14855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7368"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="42270" checksum="94CBEDC9DA61FC51" modified="2015-06-24" version="1">MQTANKFSVSRYAPERGPVAKLTARDSVLRRLDWPILLSALALSLLGALLVWSATRNRTTLNQGDPYYFLTRHAMNTGIGLVLMIGTIWLGHRTLRGAVPILYGLSLILVLAVLTPLGSTINGAHAWIVIGGGFSLQPGEFVKITIILGMAMLLAARVDAGDLEHPDHRTVVKALCLAAAPMGIVMLMPDLGSVMVMVVIVLGVLLASGASNRWVVGLLASGVAGAVLIWQLGVLDEYQINRFAAFANPELDPAGVGYNTNQARIAIGSGGLLGSGLFKGSQTTGQFVPEQQTDFVFTVAGEELGFVGAGLILVLLGVILWRACVIARETTELYGTIVCAGIIAWFAFQAFENIGMTLGIMPVAGLPLPFVSYGGSSMFAVWVAVGLLQSIRVQRPMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK0</accession>
    <name>A0A0F4JGK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32893">
        <property type="protein sequence ID" value="KJY32893"/>
        <property type="gene ID" value="VR44_14925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470918" evidence="2">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="14821" checksum="63A1B247F683FAC8" modified="2015-06-24" version="1">MTVTVSGRVFRKTPTTLSPSVSSARPLWTTPVVTASPPPSRAMTLRWAASRTVRSGTPHAAARVVSRACSSSGRGARYQDIRAGPPAAAGRASLVAGASAALPVQKARCPGSASAARSRATKEANRERGPACGEGPSAGVRAASASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIT8</accession>
    <name>A0A0F4JIT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947548.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34100">
        <property type="protein sequence ID" value="KJY34100"/>
        <property type="gene ID" value="VR44_12620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6590"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470537" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1148" mass="121844" checksum="3B1FF27DE9E22E19" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJJ8</accession>
    <name>A0A0F4JJJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947435.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34390">
        <property type="protein sequence ID" value="KJY34390"/>
        <property type="gene ID" value="VR44_12005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6486"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="45269" checksum="FF0AE4061BC159B9" modified="2015-06-24" version="1">MSDLARPDRPLRPLRDLPRRLLARRRDPVVVQSVRSTGAAVVSYVVALRLSNEPAPLTAPLTALLVVQVTLYSTLTTGVRRVNSVVAGVLVAVGFSALVGLTWWSLGLVILASLVVGHLVRVDEFVPEVAISAMLVLGVTRVADTAWDRVLETLIGAVVGLAFNLLFAPPVWVEPAGRAIDDLAARMAALMTGMADELTGRTTVAEAATRLHEARRLDNDIAGVDAALRQAEDSLRLNPRVREGLLFRLVLRTGLDTLEICAVVLRVSARALTDLAKARTDEPLFSPPVTRALQDLFGHMALAVHSFSRLITAQVTTNAEEQEERLTRELGMAREARDRLAHLLLEQLRTEPGQWQLHGALLADVDRVLDELDVDKRSQRLMEELDRHSRLRHEGGTRLSRALRRGRRISGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJK5</accession>
    <name>A0A0F4JJK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_11730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947381.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3719"/>
    <dbReference type="EnsemblBacteria" id="KJY34512">
        <property type="protein sequence ID" value="KJY34512"/>
        <property type="gene ID" value="VR44_11730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6313"/>
    <dbReference type="eggNOG" id="COG3648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="35326" checksum="F1F98576ADEC39A3" modified="2015-06-24" version="1">MATILGQNQYGKAENRVVKITRDGDTHHIKDLNVSVALSGDMDDVHYSGSNANVLPTDTTKNTVYAFAKEYGIESAEQFGIHLARWFVNSQEPIQRARIRIEEYAWDRIATSDANSKFIGSDEVNHSFVRKGMETRVTQITYDGQNWEVISGLKDLIVMNSTNSEFWGYVKDKYTTLQEAYDRILATQVSGRWRFNWSDDEQRMPNWEKSYAETKKHMLQAFAETYSLSLQQTLYQMGSRIINHRSEIDEVRFSLPNKHHFLVDLEPFGLKNDNEVYFAADRPYGLIEATVLRDGADARIPVDMTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJM5</accession>
    <name>A0A0F4JJM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000320">
        <property type="protein sequence ID" value="KJY34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000320.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene496"/>
    <dbReference type="EnsemblBacteria" id="KJY34004">
        <property type="protein sequence ID" value="KJY34004"/>
        <property type="gene ID" value="VR44_12825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6647"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="29757" checksum="2C731CCC8E6393E5" modified="2015-06-24" version="1">MSDSPAARLQKLFEGHRLTPTQRRIAHCMVRGAAEVPFLSSVELAELAGVSQPSVTRFAVALGFDGYPALRRHLREVAPAEPPRVVREESYNEYQQAVEGEIENLRRLATMLADPAPVEEAGRLLAGSSPLPVLGLRAASSQARGFAYFAAKVHPDVRLLDEGGSMLADRIDAAATAGASALLCFALPRHPREVLEALEHARGAGLTTVTVADSAFAPVARYSDLLIPAPVGTGLAFDTACAPMLLGRVLLEAMADALPDAQARLESFDARAAARGLFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJR8</accession>
    <name>A0A0F4JJR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_14305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000369">
        <property type="protein sequence ID" value="KJY33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947858.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000369.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33221">
        <property type="protein sequence ID" value="KJY33221"/>
        <property type="gene ID" value="VR44_14305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7208"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="22476" checksum="F7B4B3015094ECBE" modified="2015-06-24" version="1">MTTTGAGADTAPRTYGGSRALALLLVITGAAALLAAWVITIDKFKLLEDPNFTPGCSLNPVVSCGNIMKSEQASAFGFPNPMLGLVAYGIVICVGMSLLAGARFARWYWLTLNAGMLFGVGFCAWLTYQSLYNINSLCLWCCLAWVCTILMFWYVTSHNIRQGMLPAPGWLRGFLDEFTWVLPALHIGIIGMLILTRWWDFWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJU6</accession>
    <name>A0A0F4JJU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947573.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000318.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34038">
        <property type="protein sequence ID" value="KJY34038"/>
        <property type="gene ID" value="VR44_12755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6631"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="33559" checksum="4520B3FB78A24E55" modified="2015-06-24" version="1">MTRVAGIDCGTNSIRLLVADCDPATGELVELDRRMTIVRLGQGVDKTGRLAPEALERTFAACREYAAVIKELGAERIRFVATSASRDAENREDFVRGVLDILGVEPEVISGDQEAEFSFTGATKELTGTAHLERPFLVVDIGGGSTEFVVGEEHVEAARSVDVGCVRMTERHLVVDGEVTDPPTAEQIAAMRADIEAALDLAAETVPLERARTLVGLAGSVTTVAAIALDLPEYRSERIHHSRISYEQVREISGRMLTATHAERSAIPVMHPGRVDVIGAGALVLLAIMERTGAAEVVVSEHDILDGIAWSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL31</accession>
    <name>A0A0F4JL31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34519">
        <property type="protein sequence ID" value="KJY34519"/>
        <property type="gene ID" value="VR44_11765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6320"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12965" checksum="86E3ACC106761DCC" modified="2015-06-24" version="1" fragment="single">MSKRTLTTESGAPVADNQNSATAGVGGPLLIQDQQLLEKLARFNRERIPERVVHARGSAAYGYFEVTDDVTAYTSAKFLSEVGKKTETFLRFSTVADSLGGADAVRDPRGFALKFYTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMA9</accession>
    <name>A0A0F4JMA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">VR44_10115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947082.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35477">
        <property type="protein sequence ID" value="KJY35477"/>
        <property type="gene ID" value="VR44_10115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5623"/>
    <dbReference type="eggNOG" id="ENOG50333JS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7733" checksum="7501EF72379E6187" modified="2015-06-24" version="1">MATKDTGGGQQKATRSTEEVEEQAAEAQSDLKERQEKLSDDVDSVLDEIDDVLEENAEDFVRSFVQKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMB3</accession>
    <name>A0A0F4JMB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_10145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35482">
        <property type="protein sequence ID" value="KJY35482"/>
        <property type="gene ID" value="VR44_10145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5629"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="42467" checksum="4BE0B8A6805E64A1" modified="2015-06-24" version="1">MADTDETGERPAKRSEPGGGILMGRPFGVPVYVSPSWFLVAALITWVFGDQLDRILPDLGPARYLVSLFFAVAFYASVLVHELAHTIAALRFGLPVRRIQLQFFGGVSEIEKESETPGREFVLAFVGPLLSLALAGIFYLGMNAVDPATVPGVLLGGLMVSNLLVAAFNLLPGLPLDGGRMLRALIWGITGKPMTGTVAAAWVGRALAITVLIGLPLITQTGVLGNPTQDIGGMDTVMDALLAAILAAIIWTGAGNSLRMARLREHLPELRARTLTRRAIPVQAATPLSEALRRANEAGARALVVVDGQGDPTAIVRETAIASVPEHRRPWVAVSTLAQDLTDGMKVSAELTGEELLDHLRTTPATEYLVLETGGEIYGVLSTLDVEKAFVKAMARPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMK4</accession>
    <name>A0A0F4JMK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal peptidase I</fullName>
            <ecNumber evidence="2">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000245">
        <property type="protein sequence ID" value="KJY35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947234.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000245.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35054">
        <property type="protein sequence ID" value="KJY35054"/>
        <property type="gene ID" value="VR44_10930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6066"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470698" description="Signal peptidase I" evidence="3">
        <location>
            <begin position="33"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25666" checksum="45ACE65FF08035FA" modified="2015-06-24" version="1">MTHRSGRRRGIAAIVLLVLGAVILGGVTVAKAVNPPAHYSEGRAAGWQMAPTYTDGESIYLEPVDGKLRRGDIVLASVPWSLQKTQMNRVIAVGGDRIRYKPSSKVAGQYRLVLNGDPLDEPYLEQWKNPSAVAFDVTVPEGSVFLMADNRMNSDGSQYANNGPVPVDKVVSKVVMYPMAKLAVWGQLGGGLVLVAGAVLGLVSRRARKAAAAPVAPAEPPSQPVVAAAAAATAATAGERSDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMR4</accession>
    <name>A0A0F4JMR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947214.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3388"/>
    <dbReference type="EnsemblBacteria" id="KJY35114">
        <property type="protein sequence ID" value="KJY35114"/>
        <property type="gene ID" value="VR44_10815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6013"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="25973" checksum="6CF2DF495875D559" modified="2015-06-24" version="1">MVRPRRIVLVRHGESEGNIDDTVYEREPDHALRLTRAGREQAAEAGVRLRELFGEEHISAYVSPYRRTLQTFRELRLDPARVRMREEPRLREQDWGNWQDRDDVKLQKAYRDAYGHFFYRFAQGESGADVYDRVGSFLESLYRSFEAPDHPENVLLVTHGLTMRLFCMRWFHWSVAEFEALSNPGNGEFRVLMLGPDGRYRMDRPFERWTTPEPYDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMW4</accession>
    <name>A0A0F4JMW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35164">
        <property type="protein sequence ID" value="KJY35164"/>
        <property type="gene ID" value="VR44_10735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5896"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24754" checksum="F717F51372843DD3" modified="2015-06-24" version="1">MDAVTFRTTEADAPSTLDRRNGPHGEVVLRRRDDIYEIIVNGCFLMDTSDGRSERLLLDAALRRTTAAEPAVLIGGLGVGFSLAHASGQPRWSRIVVVEREDAIIDWHRAGPLGAFTADALSDPRVSILHADLNDHLRTSGERYDALCLDIDNGPDWTVTEDNGSLYSPSGLAACRARLAPGGVLAIWSARPSPAFEGALARAGFEDVHSEEVPVARGVPDVVHLARNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNJ5</accession>
    <name>A0A0F4JNJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000200">
        <property type="protein sequence ID" value="KJY35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946922.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000200.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35775">
        <property type="protein sequence ID" value="KJY35775"/>
        <property type="gene ID" value="VR44_09255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5116"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="41066" checksum="46C3AC4C7E9DF09D" modified="2015-06-24" version="1">MRAHPLATDAVLALGALVSMLLGSFVDPHGPLGPTFRTRAPEPVSLLLMLLGAAALVFRRRSPRTVLAVTCGLTLVELATGEPRAPVAMSAVIALYTVAARTDRPTTWRTGLLTMAGLTGVAMLAGPLPWYAQENIGIFAWTGMAAAAGDAVRSRRAFVDAIRERAERAERTREEEARRRVAEERLRIARDLHDVVAHHIALVNVQAGVAAHVMDKRPDQAKEALAHVRDASRSALNELRATVGLLRQSGDPEAPTEPAPGLAVLDELLDTFRHAGLPVDATVQLGTEAEALPAAVDLAAYRVIQEALTNVRKHAGPGAQAQVSVVRVGASVEVTVLDDGGDSADSSPAPAPPGGGHGHLGMRERAGALGGSCFTGPRYGGGYRVHAILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPI7</accession>
    <name>A0A0F4JPI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946801.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene957"/>
    <dbReference type="EnsemblBacteria" id="KJY36095">
        <property type="protein sequence ID" value="KJY36095"/>
        <property type="gene ID" value="VR44_08600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4862"/>
    <dbReference type="eggNOG" id="ENOG5032NFP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="10263" checksum="013C33B5811891D7" modified="2015-06-24" version="1">MSRATLVPFPSCVQHGRCTVRAMSRHVTIRLDEEFHDRLKARAAALGTTVTALITEVTERELDEDRKNFLSGIEEFADHWGYFQERFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPS1</accession>
    <name>A0A0F4JPS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chloramphenicol phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000202">
        <property type="protein sequence ID" value="KJY35748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946933.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000202.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35748">
        <property type="protein sequence ID" value="KJY35748"/>
        <property type="gene ID" value="VR44_09305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5188"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012853">
        <property type="entry name" value="CPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007531">
        <property type="entry name" value="CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="18976" checksum="92FB02D9433EB627" modified="2015-06-24" version="1">MIVLNGGSSSGKSGIVRCLQAVLPDPWLAFGVDTLVDAMPPSLRTSDAGIGFADGGEVLVGETFRTLDTAWAHGIAAMARAGARIVVDDVFLGGPESQQRWRKALEGLDVLWVGVRCDAEVAAAREIARGDRPSGMAAAQAETVHRGVAYDLEVDTTRTESLTCARTIAAHVRDAEGPHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQI4</accession>
    <name>A0A0F4JQI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_08855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946850.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36008">
        <property type="protein sequence ID" value="KJY36008"/>
        <property type="gene ID" value="VR44_08855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5017"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470782" description="Histidine kinase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4118" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="22862" checksum="924D5E558DB27D77" modified="2015-06-24" version="1" fragment="single">NAALILVVAVVAVAATGTRTAGAVAALSAAAWFDFFLTVPYQRFTITGRQDVETAVLLLVVGLIVSQLSVRARRLQTTVITDAARLASLRGTARLAEDGRSPEAVVEYVRRELVGLLGLRGCRFEYGNLMGGLPRLEHDGGVWLRRPDRVTEYADWPDDETELRVVGGGHYYGRFLLDPLPGPLPPEQDRLVAVALAAQAGSALDTAGLDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQT8</accession>
    <name>A0A0F4JQT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946773.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36113">
        <property type="protein sequence ID" value="KJY36113"/>
        <property type="gene ID" value="VR44_08455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4754"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="8856" checksum="7FA3BE12699B5D5C" modified="2015-06-24" version="1">MNGTSREEDGAHEDTALPAALGLCMLAVGGWLLTTARPWHKPGTPLTLGLGWAVSGALLLAGLSLLTRCVRTVHGAPEAAQEPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRY1</accession>
    <name>A0A0F4JRY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_09385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946944.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35711">
        <property type="protein sequence ID" value="KJY35711"/>
        <property type="gene ID" value="VR44_09385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5205"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="29"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="552" mass="60851" checksum="BDCBFC0F447BA2AC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRZ8</accession>
    <name>A0A0F4JRZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_07875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946661.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000154.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36528">
        <property type="protein sequence ID" value="KJY36528"/>
        <property type="gene ID" value="VR44_07875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4282"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="39003" checksum="FB7FB1D0768136A0" modified="2015-06-24" version="1">MTRDLVLHDWVVAAIALASGGAAGLLLRALLKWLAKHAERTKWTGDDIIVDALRTLAPWAAVIAGAAVAATALPLTARVGGLVNQSLTALLIIFATFTAARVVAGLVQSVAQSRTGVAASATIFVNITRIVVLTMGVLVALETVGVSIAPLVTALGVGGLAVALALQDTLANLFAGVHILASKTVQPGDYIRLSSGEEGYVVDINWRNSVVRNLSNNLVIIPNGRLARTNMTNFTQPEAKLSLLVQAGVGYDSDLEHVERVTLDVVDGVMADIEGGVPDHEAKVRFHTFADSRINFTVILGVGEFSDQYRIKHEFIKRLHQRYREEGISIPAPTRTVSFRPEEDPRPAGSAVVPHQRDGSPIARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS48</accession>
    <name>A0A0F4JS48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="7" type="ORF">VR44_07480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="JZWV01000146">
        <property type="protein sequence ID" value="KJY36659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946591.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000146.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2257"/>
    <dbReference type="EnsemblBacteria" id="KJY36659">
        <property type="protein sequence ID" value="KJY36659"/>
        <property type="gene ID" value="VR44_07480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3971"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16590" checksum="47A2A247752BB8B0" modified="2015-06-24" version="1">MSTQSRLTHIDEAGAARMVDVSTKDVTTRTARASGRVLVSSRVIELLRGEGVPKGDALATARIAGIMGAKKTPDLIPLCHPLAVSGVRVDLKVADDAVEILATVKTTDRTGVEMEALTAVAVAGLTVIDMVKAVDKGAVITDVRVEEKTGGKSGDWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS96</accession>
    <name>A0A0F4JS96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000196">
        <property type="protein sequence ID" value="KJY35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000196.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5127"/>
    <dbReference type="EnsemblBacteria" id="KJY35826">
        <property type="protein sequence ID" value="KJY35826"/>
        <property type="gene ID" value="VR44_09080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5080"/>
    <dbReference type="eggNOG" id="ENOG5033JSG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="9111" checksum="5322C1967350D001" modified="2015-06-24" version="1">MTTVPLPTDTTRWRCTLCGNLTRFDVTRSSKVVEYVHLDLAGEPKVEEREVVSETIESVRCRWCNAVDQIELVDRPGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSK8</accession>
    <name>A0A0F4JSK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_05840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37357">
        <property type="protein sequence ID" value="KJY37357"/>
        <property type="gene ID" value="VR44_05840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1983"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="487" mass="52792" checksum="A3F5C449FF39596B" modified="2015-06-24" version="1">MCDQVTALVRSGQLRPGDAMPPSRELARQLDVSRTVVIRAYELLRAHGILTARRGSGTKVAGLAGGAAPPRAPRTTPPVLAPQPPRATDGGDALWQPWEPAPTHHPRTALDFRHGTPALADFPVARWRQSLHEAYGRADAAALGYGPAEGSPALRREIASLVRQSRALDPSPDHIMVTGGATQALDILTRMLVRQGDVVVIEDPSHTVLRQVFGCSEAAVVPVPVDEEGLRVADIDACVRAQGHDPARVKLVYVTPSHQFPTGFIMSGTRRRALLEWAYAHGATVLEDDYHNEFTFSAERLPALAAERHRDTVVYVGSFSKTLFPALRIGYAVLPPDLVRPFLGIKWITDRLTPMIAQEALGSFISTGAYARHISRMTRLYRQRRSRLLEALYEHFGAELRISGEAAGLHVLVTLIGARGVPEDRITRLAAARGVRIYPASGYFVQDPPAEPTFLMGYAALPVAQITEGVALLAAAVREATGRPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSY7</accession>
    <name>A0A0F4JSY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946831.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36071">
        <property type="protein sequence ID" value="KJY36071"/>
        <property type="gene ID" value="VR44_08705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4984"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="208"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="471"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="552" mass="57990" checksum="361372665F13BC76" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT35</accession>
    <name>A0A0F4JT35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946462.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36974">
        <property type="protein sequence ID" value="KJY36974"/>
        <property type="gene ID" value="VR44_06755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3430"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9865" checksum="4720BC95467F2950" modified="2015-06-24" version="1">MLERKQLKGRTQVTFVLPEDTPGGPVSVVGDFNHWDPAAHPLTSRGDGSRAATVVLPAHGHHSFRYLAAGGHWFDDDQADAHDGANCRVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT83</accession>
    <name>A0A0F4JT83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000099">
        <property type="protein sequence ID" value="KJY37567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946216.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7147"/>
    <dbReference type="EnsemblBacteria" id="KJY37567">
        <property type="protein sequence ID" value="KJY37567"/>
        <property type="gene ID" value="VR44_05450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1726"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="42699" checksum="49453EEC291FFB3C" modified="2015-06-24" version="1" fragment="single">WQAGRGERAAGPGLGTPVERATFHTLYTASLAAPPLRAGLTEDAARKAARRLRSLLGTEALCLTDREAVLAWDGPGADHHQRRAMARVAVMLESGRSQSLRTECQRPDCPLKWAVFAPLTGEDGVLGALVAYGSRESAVLVRAATEVARWVSVQLELSELDRARTRLMEAEIKALRAQISPHFIFNSLAAIASFVRTDPERARELLLEFADFTRYSFRRHGEFTTLAEELRSIERYLALAGARFGDRLKVTLQVAPEVLPVALPFLCLQPLVENAVKHGVEDSAGECRITIAARDAGAEAVLTIEDNGVGMDPARLRRILAGERAGSSSGIGLPNVDERMRQVYGDDYGLVVETGVGAGMKVTVRIPKYRAGVHTTAPRPPAGPAGGGASHEAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTN3</accession>
    <name>A0A0F4JTN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000103">
        <property type="protein sequence ID" value="KJY37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946235.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000103.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37515">
        <property type="protein sequence ID" value="KJY37515"/>
        <property type="gene ID" value="VR44_05570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1927"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21603" checksum="3B2874616166354F" modified="2015-06-24" version="1">MSRMSITNTPTTASVDDAADISRSLARAFADDPMMCWFFPDEATREERMVRYFATLLTRHYGRHGVCERTGLAAAFWVAPDGRALPDEETLDELATVLGDRAGVFREGILAAAEHAPPEDHWYLAVLGADPAGQGQGHGAALLRSGLAKADAAGLPVYLESSKESNVPFYEHFGFTLLGEARLPGGGPTLWVMRRAPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU49</accession>
    <name>A0A0F4JU49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946087.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37887">
        <property type="protein sequence ID" value="KJY37887"/>
        <property type="gene ID" value="VR44_04760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1032"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="8017" checksum="D1856D63DC347B44" modified="2015-06-24" version="1">MIADGVRAIWCREFERDDIGPDDDFFALGGQSLIMTKIQGAYIEELGAEVPMDQMFLNPTIASISAYIESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV38</accession>
    <name>A0A0F4JV38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ORF">VR44_03900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945934.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene764"/>
    <dbReference type="EnsemblBacteria" id="KJY38227">
        <property type="protein sequence ID" value="KJY38227"/>
        <property type="gene ID" value="VR44_03900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8684"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="42426" checksum="DCE767783C77857D" modified="2015-06-24" version="1">MEILILAVVIALVAVGAISGLVVSSRKKKQLPPTAPPSTPTITAPPAEPQVGEDAVETAEEPRRTIEEVGLPEAEAEAAPVEAPAAEPEAPAAPEIEVPEPTAGRLVRLRARLARSQNSLGKGLLTLLSREHLDEDTWEEIEETLLIADVGVAPTQELVERLRERVKVLGTRTPAELRGLLKEELVALVGTDFDRAVKTESGVETPAVVMVVGVNGTGKTTTTGKLARVLVADGRSVVLGAADTFRAAAADQLQTWGERVGARTVRGPEGGDPASIAYDAVKEGIAEGADVVLIDTAGRLHTKTGLMDELGKVKRVVEKHGPLDEVLLVLDATTGQNGLTQARVFAEVVDITGIVLTKLDGTAKGGIVVAVQRELGVPVKLVGLGEGADDLAPFEPEAFVDALIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV88</accession>
    <name>A0A0F4JV88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946504.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36891">
        <property type="protein sequence ID" value="KJY36891"/>
        <property type="gene ID" value="VR44_07000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3614"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="36788" checksum="1A3C2541C578EE93" modified="2015-06-24" version="1">MTTTTETVLDARGVTMRFGGLTAVKNVDLTVNSGEIVGLIGPNGAGKTTFFNCLTGLYIPTEGEVRYKGTVLPPKSFKVTAAGIARTFQNIRLFNNMTVLENVLVGRHTRTKEGLWSALLRLPSFGKEEQASREKAMELLEFIGLDHKAEHLARNLPYGEQRKLEIARALASDPGLILLDEPTAGMNPQETRAAEELIFAIRDKGIAVLVIEHDMRFIFNLCDRVACLVQGEKLIEGTAGEVQSDERVVAAYLGEPFEGAPGADEVAEVEAAEAHAEEAPAEEAPAEEAQAEAAEAEAAEAEAEAETDADAETDADTEPETPAEDDTAPAADSTTSTTTDGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVB2</accession>
    <name>A0A0F4JVB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine biosynthesis protein ThiJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7123"/>
    <dbReference type="EnsemblBacteria" id="KJY37683">
        <property type="protein sequence ID" value="KJY37683"/>
        <property type="gene ID" value="VR44_05330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1702"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="21576" checksum="934D1E93B581A823" modified="2015-06-24" version="1">MSGTRIAVLVESDFYEPEIFYYQRRFAEEGAEVDFLTRLWGNDSITFSGHEYRAPFTADKSLEGLSDEELRRYAAVIVPSGMVADRLRYTEDVDVLAPATEFLRRAFEEPTVLKGIICHGMWLASSIPGKVRGRKVVCHNNLIGDVRNMGAEYVNEDVVVDGDLVTGRTGAHHHLFARRIIELLAAGRGRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVV0</accession>
    <name>A0A0F4JVV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37954">
        <property type="protein sequence ID" value="KJY37954"/>
        <property type="gene ID" value="VR44_04595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1000"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470938" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="8966" checksum="8FFB1D0CAC13A58F" modified="2015-06-24" version="1">MMSILKSSRTSSDVSLAAVMPVPVMLFVVAFLFGDRLGGVVSVVLVVAGLGVLAWAGAVTRAKAGERARRDEAVLDALEPLAGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW95</accession>
    <name>A0A0F4JW95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945794.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38642">
        <property type="protein sequence ID" value="KJY38642"/>
        <property type="gene ID" value="VR44_03105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7836"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23655" checksum="A3E9058FA216A0FA" modified="2015-06-24" version="1">MTIRVLIVDDQMMVREGFSVLLNAMEGIEVVGEAVDGRQAIAQVAALRPDVVLMDIRMPEMNGLEATRHIVAADVDAKVLVLTTFDLDEYVYQALRAGASGFLLKDASARQLAEGVRVVAAGEALLAPSVTKRLIVEFSKLSEVSRATDPAGVGELTERETEVLVLIAQGLSNAEIADRLLVAESTIKTHVSRILVKLGLRDRTQAAVYAYETRLVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWP5</accession>
    <name>A0A0F4JWP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000049">
        <property type="protein sequence ID" value="KJY38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945742.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38797">
        <property type="protein sequence ID" value="KJY38797"/>
        <property type="gene ID" value="VR44_02815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7293"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="243"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="478" mass="49026" checksum="044587A31C3A5D7B" modified="2015-06-24" version="1">MGIVAGLDSSSTFTRIVVCDTDTGAVLRQGYAPHPQPAGETLPHETDPQAWLLSLGEAAGGGLLEGVQAIGVSARRGLLALDAQGGPVRPALVGNDRRGQVAAADLVEALGGKAAWTAAVGSVPHPAQPVVKLAWLARTDPEAARRVAVLMSPHDWLVWQLLGRPARRTTDRADASGTGYWSAATGSYRPDLVELALGHQALLPEVLGPCDAAGMTPEGLLISAGTGETTAAVLGLGLGPGDAVVSLGATGSVMAVHHEALAEPGGLITALADAGGMHLPVVNTSNAVRTLRGTADMLGTDLEGLSALALKSTPGAHGLVLLPYLEGERTPHLPHSAGTLSGLRRDSMKPEHLARAAFEGMLCGLVDALDVLRHRGVGIRRVFLLGAVAELPAVQAAAPGLFGTQVVVPAPADYAALGAARQAAWALGAQQGTLAPNTPPLWPAPAAQVFEPGEEFAAWQAVRQQYVTTREQLHPGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXE0</accession>
    <name>A0A0F4JXE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein B/C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945652.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39027">
        <property type="protein sequence ID" value="KJY39027"/>
        <property type="gene ID" value="VR44_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6765"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="101"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23222" checksum="0AE81F1F51DDA848" modified="2015-06-24" version="1">MTTRDRILARIRRAVPAPAPDEATPEAALAAIPRDYLRVHDATWTPARTADLLAANLTEYRAKVHRTDEAGLPPLLARLLSGSRTVLIPPALPPHWLSGTSATLVPDQESSNAHDLDGVDSTVTGCALAIAETGTIVLDGGPDQGRRRITLIPDHHVCVVRVPSQVVDSVPQALERLDPTRPLTWISGPSATSDIELDRVEGVHGPRTLDVILLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY53</accession>
    <name>A0A0F4JY53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945541.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6018"/>
    <dbReference type="EnsemblBacteria" id="KJY39312">
        <property type="protein sequence ID" value="KJY39312"/>
        <property type="gene ID" value="VR44_01775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5759"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12487" checksum="DDB7D2CDBEB89F0D" modified="2015-06-24" version="1">MTADDSYGRLDDDDYPAYTMGRAADMLGTTQGFLRAIGEARLITPLRSAGGHRRYSRYQLRIAARARELVDQGTPIEAACRIIILEDQLEEAQRINAEYRRAAESAPPPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYM2</accession>
    <name>A0A0F4JYM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_02645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945709.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38924">
        <property type="protein sequence ID" value="KJY38924"/>
        <property type="gene ID" value="VR44_02645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6835"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014165">
        <property type="entry name" value="LigK_PcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02798">
        <property type="entry name" value="ligK_PcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="24487" checksum="624F103A4D791B6D" modified="2015-06-24" version="1">MEHTRLGVVHTAITRADPKDVAALSAFGVATVHEAMGRVGLMRPYLRPAYTRARLCGTAVTVLLQPGDNWMLHVAAEQIEEGDVVVAACTTESEDGFFGELLATSFRARGGRGLVIDGGVRDVSELEEMDFPVFARAVNAKGTVKATLGSVNVPVVCANALVRPGDVVVADRDGVVVVPRERAAEVAEAAARREAGEESKRERFRAGELGLDLYGMRGPLAELGLRYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYX6</accession>
    <name>A0A0F4JYX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000074">
        <property type="protein sequence ID" value="KJY38206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945954.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000074.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38206">
        <property type="protein sequence ID" value="KJY38206"/>
        <property type="gene ID" value="VR44_04025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8710"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="31894" checksum="164653E741CE5E48" modified="2015-06-24" version="1" fragment="single">DLERAAADGVRFVCPGSAEWPTQLDDLGDARPVGLWLRGRPNLRTWALRSVAVVGARACTPYGAHMAQTLAAGLAERGWVVVSGAAYGIDGAAHRGALASGGATAAVLACGVDTVYPRGHAGLLGRITRQGLVIGELPPGSHPTPSRFVLRNRVIAALTRGTVVVEAARRSGSLVTARRAQQLGRLTMGVPGPATSGLSAGVHELLRGEAVLVTDAAEVVELVGDMGELAPVRHGPVLARDLLDPAAARVLEALPAGRPADVDEISLGAGTGTDEVIGRLYELHSLGFVERQGDAWRLTRRRPKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ69</accession>
    <name>A0A0F4JZ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945681.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39003">
        <property type="protein sequence ID" value="KJY39003"/>
        <property type="gene ID" value="VR44_02515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6807"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6788" checksum="9BF29ECE1791917C" modified="2015-06-24" version="1">MERGRDVHDAGNGACDAHEYVGQCRVGHVALHRYSTVVDVYVYVYVHDRRAGRADRFPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZZ0</accession>
    <name>A0A0F4JZZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">VR44_00280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1024"/>
    <dbReference type="EnsemblBacteria" id="KJY39932">
        <property type="protein sequence ID" value="KJY39932"/>
        <property type="gene ID" value="VR44_00280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.54"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="22994" checksum="59920E49937513B5" modified="2015-06-24" version="1">MSTIDILSPAGDKAGTVELPAEIFDAKTSVPLIHQVVVAQLAAARQGTHKTKTRGEVRGGGKKPYRQKGTGRARQGSTRAPQFAGGGVVHGPVPRDYSQRTPKKMKAAALRGALSDRARHSRIHVVTGVVEGAASTKAAKTLFGKISERKNLLLVAERSDELAWLSARNLPQVHILEPGQLNTYDVIVSDDVVFTQAALESFVSGPKADETEGNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K100</accession>
    <name>A0A0F4K100_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945388.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4759"/>
    <dbReference type="EnsemblBacteria" id="KJY39608">
        <property type="protein sequence ID" value="KJY39608"/>
        <property type="gene ID" value="VR44_00930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2898"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="274"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="491" mass="54780" checksum="B7F4B6A341574726" modified="2015-06-24" version="1">MPNANEDNPSALSQVQRRAVSELLRVAPVADELGRRFQEAGFRLALVGGSVRDALLGRLGNDLDFTTDARPQDVLKIIRPWADSVWDVGIAFGTVGAQKAARVGDAVRNFQIEVTTYRSEAYDRTSRKPEVSYGDSIEEDLVRRDFTVNAMALALPEQEFVDPHGGLEDLAAGVLRTPGTPQDSFSDDPLRMLRAARFAAQLDFEVAPEVVAAMKAMADRIEIVSAERVQAELNKLLLSAHPRKGLALLVDTGLADRFLPELPALRLESDEHHRHKDVYDHSLIVLEQAIALEEDGPDLVLRLAALLHDIGKPRTRRFESDGRVSFHHHEVVGAKMTKKRMTALKYSNDMVKDVSRLVELHLRFHGYGDGEWTDSAVRRYVRDAGPLLERLHKLTRSDCTTRNKRKANALSRTYDGLEERIAQLQEQEELDAIRPDLNGNEIQQILEIGPGPAVGKAYAFLLDLRLENGPMEHEAAVAALKQWWAEQAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1K0</accession>
    <name>A0A0F4K1K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945622.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39096">
        <property type="protein sequence ID" value="KJY39096"/>
        <property type="gene ID" value="VR44_02190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5703"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="21198" checksum="4714E6F844C7EA2A" modified="2015-06-24" version="1">MAISVIVGGSRVLFLEALVEALRSAGDIEVIAAETDPQHVLSLVHRHSPDVVLLEDTPVGDDVLRLASAVRARVPACGIVLMMAGNRPAAVGRAMAAGVHGIVPTDTGLPRLIATLKGVAAGCVTMAPSLASSAMGLGIPGAGPGTKLSTRESQVLRLTAGGATVKEIAAELYLAAGTVRNVTSASIKKLGGRNRFDAARIAVEQGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2C8</accession>
    <name>A0A0F4K2C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39336">
        <property type="protein sequence ID" value="KJY39336"/>
        <property type="gene ID" value="VR44_01935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6506" checksum="632CDE3C70C5D05E" modified="2015-06-24" version="1" fragment="single">MTAVQAAASVQPAPPFKLALVGGGPRATYLLERLSATIGRLDAGRRLEVHVFERSGAFGAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAY1</accession>
    <name>A0A0F4IAY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001582">
        <property type="protein sequence ID" value="KJY18829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18829">
        <property type="protein sequence ID" value="KJY18829"/>
        <property type="gene ID" value="VR44_39385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5964"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9505" checksum="D172D026D9BF5782" modified="2015-06-24" version="1">MSEQYEYVPHRLLRQQVRDIASGAEGVLMAVINENVSDRVGREHWMELAYIRGASGREFTTAVANVHPAHDQPQSAVSRRDQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBH1</accession>
    <name>A0A0F4IBH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001555">
        <property type="protein sequence ID" value="KJY19352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19352">
        <property type="protein sequence ID" value="KJY19352"/>
        <property type="gene ID" value="VR44_39150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5594"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7390" checksum="8FA51476279E5F90" modified="2015-06-24" version="1" fragment="single">GRQVTALVRNGRTDPNPSTDPNDPNGPTGVAVPPGTDERWITETPSLETLLLAHLRSPDPAPQAPGKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEE6</accession>
    <name>A0A0F4IEE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_39270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001569">
        <property type="protein sequence ID" value="KJY19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952477.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19016">
        <property type="protein sequence ID" value="KJY19016"/>
        <property type="gene ID" value="VR44_39270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5655"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="42902" checksum="53D2C31BC2E40CAC" modified="2015-06-24" version="1">MPKHPSPAGSPAAQSFTVLHLVQPVEGGVARVVTDLVRAQSAAGLRVVVGCPDGGVLADGARDAGAEVFTWRAGRSPGPGLPAEVLAAARLVRRVRPDLLHAHSAKAGLAGRIAVRGSLPTVFQPHAWSFDAVGGTTAALALRWERAGARWADRVLCVSEAERRAGESEGITARWAVIRNGVDLTHFRPGHPDPGRDRAEARAGLQLPAGDGPLAVCVGRLCPQKGQDVLLRAWPEVRATVPGARLALVGDGPDADRLRRSAPPAVHFAGAAADIRPWLRAADLVVLPSRWEGMALAPLEAMACGRPVLVSDVSGARESLPSGHGRLCLVPPEDPAALAKALGRLLAEPRLLTELGEQAQQHARSEFDVRRTTDAVTGLYHELLGRPAPLLRRGDPQPLNQERISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEJ2</accession>
    <name>A0A0F4IEJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001533">
        <property type="protein sequence ID" value="KJY19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19903">
        <property type="protein sequence ID" value="KJY19903"/>
        <property type="gene ID" value="VR44_38935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="4">
        <location>
            <begin position="218"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="514" mass="53883" checksum="B1C4962745F39374" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIW1</accession>
    <name>A0A0F4IIW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001449">
        <property type="protein sequence ID" value="KJY21639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene580"/>
    <dbReference type="EnsemblBacteria" id="KJY21639">
        <property type="protein sequence ID" value="KJY21639"/>
        <property type="gene ID" value="VR44_38220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5253"/>
    <dbReference type="eggNOG" id="COG2049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY21639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6411" checksum="9194B1919705E69F" modified="2015-06-24" version="1" fragment="single">PRTAVPAGSLALAGEYAGVYPRSSPGGWQLIGSTDTVLWDPAREPAALFAPGVRVRFEEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INX9</accession>
    <name>A0A0F4INX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001396">
        <property type="protein sequence ID" value="KJY23364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23364">
        <property type="protein sequence ID" value="KJY23364"/>
        <property type="gene ID" value="VR44_37645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5034"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="15479" checksum="6F36E8F5D4B87477" modified="2015-06-24" version="1" fragment="single">LGDTALMQIAATCAGFEVDGMRADIVMARTATALAAWAGRTSVLKEDVRQAALLALPHRRRRNPFDAPGLDEDKLDEILDGFPDEEPEPEPDPEPQGPDDDGGGPDGSPDGGDGGGDGGGVPPQGGGPETGHAPDAPQPQESPEAQPSAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPJ0</accession>
    <name>A0A0F4IPJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001327">
        <property type="protein sequence ID" value="KJY23935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952022.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001327.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23935">
        <property type="protein sequence ID" value="KJY23935"/>
        <property type="gene ID" value="VR44_36815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4675"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470149" evidence="1">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="37190" checksum="776DDBF8166A42B6" modified="2015-06-24" version="1">MPIRTRLRAAAALLTAALAAVAVSATPAASAGSAPGAPAAAGDLRYSASTGVGVHNAYEKAKYPYLADALDSGAAMLELDVWTNFFGSGWRVSHDNPFGNNSNCENATSPAQLRTKSRDQNLAGCLSDIRSWHDAHPGHRPVVLKLELKDGFAANLGRGPAALDSLLTSKLGDALYTPGRLAAGYPDLDAAARADAWPTRAQMAGRFLVELIPGTVEEGNGADKLWTDREYAEHLRGHLATAAAFPAVHRAESGDPRNRYADPALRPWFVVFDGDASAYASGSIDTTWYDRNHYLLIATDAQNVAPAIDAVHPTEAQALDRVALMASRHASITSADWYPLPSVLATVLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ99</accession>
    <name>A0A0F4IQ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001270">
        <property type="protein sequence ID" value="KJY24200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951872.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001270.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24200">
        <property type="protein sequence ID" value="KJY24200"/>
        <property type="gene ID" value="VR44_36040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4366"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="22920" checksum="3451AEF8CAE99C73" modified="2015-06-24" version="1">MSFTGRVFSDRADAGRVLADALRHLAGADPVVLGLPRGGVPVAYEVARALGAPLDVIVVRKLGVPGHQELGFGAIGEGGVRILNEDIVRRSRTSRADLDSVERAEEAELVRRAARYREGRARVPLAGRTVIVVDDGIATGATAAAACAIARASGAARVVLAAPVAPPEAVTALRGAADEVVCPSVQPAFRAVGEWYRDFSQTSDEEVVAVLARSAAGPGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRV3</accession>
    <name>A0A0F4IRV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001177">
        <property type="protein sequence ID" value="KJY24722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951590.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24722">
        <property type="protein sequence ID" value="KJY24722"/>
        <property type="gene ID" value="VR44_34520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3888"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7682" checksum="68511A603363D608" modified="2015-06-24" version="1">MSATPLSTSGLLNSARWRRSSRSTGMNNCVEAAALTGGLLAVRDSKRTDGPAVLFTGPAWDGFLASVRTDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS17</accession>
    <name>A0A0F4IS17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001256">
        <property type="protein sequence ID" value="KJY24278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951834.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001256.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24278">
        <property type="protein sequence ID" value="KJY24278"/>
        <property type="gene ID" value="VR44_35840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4324"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="21374" checksum="BB408DB38E93B1A4" modified="2015-06-24" version="1">MKHQTHSATVRVFIALAPPDDAKEELERELLPAYEAYPRMRWNRIEDWHITLAFLGELPVATVPRLRGPLSGLAAIRRPLRLALRGGGHFDERVLWTGIDGDLEGLHLLASEVRSLVKECGIPYEGRPLRPHLTLARARRGGTADVVEAAGGLTSFSGRSWPTGRLHLVGSNIGRGPGPIHYRDIESWAFGAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISA0</accession>
    <name>A0A0F4ISA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_35610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001242">
        <property type="protein sequence ID" value="KJY24358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951791.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001242.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24358">
        <property type="protein sequence ID" value="KJY24358"/>
        <property type="gene ID" value="VR44_35610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4242"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="18387" checksum="0784D0FD6FA2FD4E" modified="2015-06-24" version="1">MRYFEDFRTGDVHELGTITVTTEEVLEFGRRFDPQPFHTDPELAAQTPFGGLIASGWHSASMFMRRYVDGLLAYSACTGSPGVDEIRYLRPVRPGDVLTARVEILGSRPSPFNPTTGVVQPKCTLSDAEGNVVFSMVLHSIFQRRPAACSTAHPCAAEDPVVRVSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISC0</accession>
    <name>A0A0F4ISC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001151">
        <property type="protein sequence ID" value="KJY24897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951499.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24897">
        <property type="protein sequence ID" value="KJY24897"/>
        <property type="gene ID" value="VR44_34015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="85"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="609" mass="63471" checksum="A1E76173D2337344" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISZ5</accession>
    <name>A0A0F4ISZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001170">
        <property type="protein sequence ID" value="KJY24779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24779">
        <property type="protein sequence ID" value="KJY24779"/>
        <property type="gene ID" value="VR44_34315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3841"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7944" checksum="E1873B799750822A" modified="2015-06-24" version="1" fragment="single">MTEVPESAHPRWLTESEQDAWYAWRRMFPLVNAEIARDLHQDSALSEADYDVLSVLGSTDGHRMRITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT02</accession>
    <name>A0A0F4IT02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001350">
        <property type="protein sequence ID" value="KJY23836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23836">
        <property type="protein sequence ID" value="KJY23836"/>
        <property type="gene ID" value="VR44_37110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4810"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14765" checksum="33529FEC6F1EE0AD" modified="2015-06-24" version="1" fragment="single">ASAGCRPLAGAAVDIWQADAAGVYSEGRESFLRGVQTTDASGRCAFRTIVPGWYAGLAPHIHFKVRPDARTETTSQFFLPEDFLREVYARQPYARRRAPRSPNAHDDRYRAAGGTMTLTPVAEGGGYRAAYTVGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF9</accession>
    <name>A0A0F4IUF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_31965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001042">
        <property type="protein sequence ID" value="KJY25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951123.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25642">
        <property type="protein sequence ID" value="KJY25642"/>
        <property type="gene ID" value="VR44_31965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3108"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="30"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="540" mass="55562" checksum="2CD1C502DBAFE846" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV16</accession>
    <name>A0A0F4IV16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001015">
        <property type="protein sequence ID" value="KJY25875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951008.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25875">
        <property type="protein sequence ID" value="KJY25875"/>
        <property type="gene ID" value="VR44_31370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2764"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="232"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="542" mass="60220" checksum="DF4CC9CE8D3E75E9" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV65</accession>
    <name>A0A0F4IV65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Large neutral amino acids transporter small subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_31270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001011">
        <property type="protein sequence ID" value="KJY25912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950990.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25912">
        <property type="protein sequence ID" value="KJY25912"/>
        <property type="gene ID" value="VR44_31270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2741"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="523" mass="54702" checksum="A40EB899CB54F066" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV75</accession>
    <name>A0A0F4IV75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001081">
        <property type="protein sequence ID" value="KJY25393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25393">
        <property type="protein sequence ID" value="KJY25393"/>
        <property type="gene ID" value="VR44_32595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3331"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="10222" checksum="15781B4C9BA5DC52" modified="2015-06-24" version="1">MAAASLRDYRLRTRDGGEEYGLTARSLELRGDVTLYLTRFSGCIEGLLCLTFSPEGLPAPPVIPPFVFMTRVSAEQALVTSDVIVTDGLRLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW08</accession>
    <name>A0A0F4IW08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000970">
        <property type="protein sequence ID" value="KJY26220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950875.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000970.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26220">
        <property type="protein sequence ID" value="KJY26220"/>
        <property type="gene ID" value="VR44_30640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2580"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22398" checksum="033447E181334565" modified="2015-06-24" version="1">MANTRSIASAASAATSAPLPFPPFPAAGPRHRLRAVDRDEVARVADLLPPGATWLPAPQHAVPTLPGQPPMVGYLVLVPADQQPIAFAPHSVPVPVPAPGAGTVAPVQPAAQPSTTTGDALVRIDTAQRTAEVDGELLDLTYLEFELLAHLVAHPHRVHSRDQLVTTVWGYGHVGDGRTVDVHIARLRRKLGAAHRGAIQTVRRVGYKYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWC5</accession>
    <name>A0A0F4IWC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000953">
        <property type="protein sequence ID" value="KJY26327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000953.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26327">
        <property type="protein sequence ID" value="KJY26327"/>
        <property type="gene ID" value="VR44_30295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2469"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21121" checksum="97529ED3336AF68E" modified="2015-06-24" version="1">MSDLEQLTQALARNLKRWRGERGFTLDALAARAGVSRGMIIQIEQARTNPSVGTTVKLADALGVSITTLLDHERSPRVHVVLPGQGVRMWSGEPGSEARMLLGDDRRGPVEMWIYRLEPGDGTASDPHPAGTFEMLHVTAGELTLEIADDRHVVPAGGAVSFEADVPHAYRNDGAVPMEMTMAVSIPPVQGADGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWL9</accession>
    <name>A0A0F4IWL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000994">
        <property type="protein sequence ID" value="KJY26024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26024">
        <property type="protein sequence ID" value="KJY26024"/>
        <property type="gene ID" value="VR44_31010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2649"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="13311" checksum="916384DAB7614D39" modified="2015-06-24" version="1">MRIKGDQTYLDEYGRTCHAGELFTGEVEEVADNGHTELLGTYCSGIEHGRQQEWWPDGTKRAEGVTIMGAAVGEWRYWHANGLPSEVVVFDENGREMSRKRWNAVGELIMDHVTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXC5</accession>
    <name>A0A0F4IXC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001091">
        <property type="protein sequence ID" value="KJY25331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25331">
        <property type="protein sequence ID" value="KJY25331"/>
        <property type="gene ID" value="VR44_32790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3370"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="35187" checksum="A54DD6FBA17D6324" modified="2015-06-24" version="1">MAYFEIPPFSDKGEAVSFGKPGGGQAAGGKQAPNSKMSMPTNPTAQFKNASTLPDGTHVAVTELDGKKSGFKGKVWVWAPKEYNDPKFAKSGFPVMIALPGGAGFPVNYWMGTDLKLQASISKWYSEGKSKPFILAMPVLNPEPDKGIYWDGSDIPNQPKMGTWLTDDVPDLMRENFRTIKSRDGWAYMGSSTGGFASLKAVLKYPEKFKAAICSGPDIVPDSPLWKGFDKEKAENNPEVLAKQLIDKKGAPDVYLAFQVGDNENNKKTLPDVQKFVATYTKGPVHTMLRVIPGGEHNAKTYVPNMGEGPIEFISKVMEGPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYC2</accession>
    <name>A0A0F4IYC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950498.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27030">
        <property type="protein sequence ID" value="KJY27030"/>
        <property type="gene ID" value="VR44_28565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2042"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="31470" checksum="E699E774F39EFE4F" modified="2015-06-24" version="1">MEEVAEHVWAYLQPDGGWCLNNAGLIAPGGGRPVLVDTAATEARARALGEAVARITPHAPRFVVNTHSHGDHTFGNRFFAGRALVVAHEAARAEMALAGLHLTRLWPDVPWGEVRVELPGLTYRDRLTLHPGDFPVELVHPGTAHTVGDTVVWLPRQRVLFTGDIVMSGATPFCLTGSVSGSLAVVERLRALGPETVVAGHGPVGGPGLLDATAGYLRLVQRLAAEGLAAGLTPLEAAREADLGPYAELLDAERLVPNLHRAYAEARGAEPGHRLDVEEMFCEMVEYHGGLPACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ18</accession>
    <name>A0A0F4IZ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000855">
        <property type="protein sequence ID" value="KJY27247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950404.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000855.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27247">
        <property type="protein sequence ID" value="KJY27247"/>
        <property type="gene ID" value="VR44_28040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1821"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26961" checksum="CEEC5ACA157FD22E" modified="2015-06-24" version="1">MNPAEGDPQRILVVDDEPAVREALRRSLAFEGYDVRTAVDGVDALDQAASYAPELIVLDIQMPRMDGLTAARRLRAAGSVTPILMLTARDTVGDRVTGLDAGADDYLVKPFELDELFARVRALLRRSSYATPAAGPAQPEDVLTFGDLRMDLATREVTRGGRQVELTRTEFTLLEMFLAHPRQVLTREQILKTVWGFDFEPSSNSLDVYVMYLRRKTEAGGEPRLVHTVRGVGYVLRAGEGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ47</accession>
    <name>A0A0F4IZ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000851">
        <property type="protein sequence ID" value="KJY27287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950387.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000851.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27287">
        <property type="protein sequence ID" value="KJY27287"/>
        <property type="gene ID" value="VR44_27945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1838"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="21142" checksum="E36BC99ED42DD856" modified="2015-06-24" version="1">MNTSGTSAPAPASPGDAAAPPVRPPAQRTGDSEGPTTPAAALGLPELRALRRDAQRDEADLSYVRRLLQGRIDILRAELARRTDPEAPVVDRLSEILADAPSRRSASARHVTLGTPQSEEFRLLAAEMLSDVELSDLDARTDAELHEAMARLVRFEQQVSRRRQQLQRTADDSSAEITRRYREGEAQVDDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZN5</accession>
    <name>A0A0F4IZN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_27485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950305.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000831.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27467">
        <property type="protein sequence ID" value="KJY27467"/>
        <property type="gene ID" value="VR44_27485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1665"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="425" mass="43192" checksum="3C21953EF838FA05" modified="2015-06-24" version="1">MGVLQGFKDVPRVVWLLAAGVFVNAVVGFTFVFVFLYLTGPRGLGAAQAGVVTGIGGIGLVAGNFTGGWYGDRFGHRRVLLAASALGGLTLMSLPLLATPLLYAALPLAQYANGVVRAANSALVAVTVPEGARRQAYAVVRCVSNGGFTLGPPLGALVAAGLSYGWLFLADGLGTLFFALWTARVVPARGAARIPAAAPDGGRGRGGVWPELRARPAVLVLLAAILVADTVYRQQYFTFPVFLADHGLDVRAFGLVIALNGAVILLLELPAAVALRTRPPLAVTGTGLVLVGAGYAALALGAGAVTAVAMMVLLSLGEILYKTTATAYVADQAPAHAVGRFQSLYAGVSVSGTVLAPPAGGALYGAAPWLLWPLCAALAAGAGAVLIRLSLRQGRAAARPAPEGAERHAVSPAPETGSRPRPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZQ4</accession>
    <name>A0A0F4IZQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000829">
        <property type="protein sequence ID" value="KJY27487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950287.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000829.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27487">
        <property type="protein sequence ID" value="KJY27487"/>
        <property type="gene ID" value="VR44_27395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1646"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="364" mass="37545" checksum="32BDDAAF0BF84E1E" modified="2015-06-24" version="1">MIETPPLVDQHCHGVLRTELGLATFEAQLVHSAGPPAAGTTFFDTQTGFAVRRWCPPLLGLEPHCAPARYLARRRELGGAESGRRLLRGSGVGTYLVDTGAPGDLTGPKELALAGDAEAFEVVRLERLAEQAADTSGTVAAFLADLAGAVHHAASGAVAFGCGPHAGYAAALDAAPEPPGPGEVRGAAGRWLAARARGGPVRDPVLLRHLLWSAVASGLPLQLHTGGAGPEPLTGFVRATAGLGARLVLLGGYPDHRHTARLAAAYPHVHADLGPALARTGARAGAVLAELLELAPFGKLLFSSGGCGLPELHAVGALVFREALGRVLGGWVADGAWSWRDADRVAGMLAAGNARRVYRLDERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1I1</accession>
    <name>A0A0F4J1I1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_26940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000804">
        <property type="protein sequence ID" value="KJY27724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950205.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000804.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3054"/>
    <dbReference type="EnsemblBacteria" id="KJY27724">
        <property type="protein sequence ID" value="KJY27724"/>
        <property type="gene ID" value="VR44_26940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1550"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="564" mass="65288" checksum="4CBDA1C744FA0871" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1N5</accession>
    <name>A0A0F4J1N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000753">
        <property type="protein sequence ID" value="KJY28195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28195">
        <property type="protein sequence ID" value="KJY28195"/>
        <property type="gene ID" value="VR44_25890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1283"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046151">
        <property type="entry name" value="DUF6153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19650">
        <property type="entry name" value="DUF6153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="17101" checksum="FC282CE95A7E65AA" modified="2015-06-24" version="1">MRTTRAERVGRPAGRPALLLLVLTVLTGLLAMHGLGPGGPARPTPGAMPHAGTTAVTHARPATGAAPHGGTTGPGAPAPAGTASATSVLARATAAHPVSAVGARVCGHEDGPAHGGRGGGHAQHADPACAASGTSGGPVLPALAPAPGGVPAGAAAAHAAPAGATAYGRAPPSLSELQLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1Q7</accession>
    <name>A0A0F4J1Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000796">
        <property type="protein sequence ID" value="KJY27804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950168.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000796.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27804">
        <property type="protein sequence ID" value="KJY27804"/>
        <property type="gene ID" value="VR44_26735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1506"/>
    <dbReference type="eggNOG" id="ENOG50348JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470046" evidence="5">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7174" checksum="EB068CB9666AC589" modified="2015-06-24" version="1">MLKKVVAAAAATGGLVLAGAGLAVADAGAQGAAIGSPGVASGNVVQVPVHVPVNVCGNTVNIIALLNPAFGNTCVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2H2</accession>
    <name>A0A0F4J2H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949900.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000730.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28455">
        <property type="protein sequence ID" value="KJY28455"/>
        <property type="gene ID" value="VR44_25330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1163"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13341" checksum="4EEDC8FD5A4FAC5B" modified="2015-06-24" version="1">MVNVETALKEATTTIEGAIGAALVDYGSGMALGHVGGGKDLDLTVAAAGNTDVVRAKVRTMEMLGLKDEIEDILITLGSQYHLIRLLKGRNSEGFFLYLALDRGRANLAMARHQLKKIEESLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2L1</accession>
    <name>A0A0F4J2L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000862">
        <property type="protein sequence ID" value="KJY27181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950446.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000862.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27181">
        <property type="protein sequence ID" value="KJY27181"/>
        <property type="gene ID" value="VR44_28290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1902"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="21243" checksum="CED03798ED4B10D1" modified="2015-06-24" version="1">MPVPHLLLDIDGVLIPFPTPDGSTPPTHLRHAVLPTGRNPDDPVPVWLNPAHGPMLTRFLADALVAPVWCTSWRKDATTIIGPLLGLPGFPYLDLPRPQITTSHPNGYLWKRDHVEPWLGESPVAWIDDDFTPLDHTWAAERTARGHPTLLIQPDPHHGLQPDHLAEVREWASHQTSPTVGISPRRAAAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2M3</accession>
    <name>A0A0F4J2M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950427.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000858.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27211">
        <property type="protein sequence ID" value="KJY27211"/>
        <property type="gene ID" value="VR44_28160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1876"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="26884" checksum="B9941E3035D8CD2D" modified="2015-06-24" version="1">MEVGALVIIFALVVLFAFLGLGAWATVKAVGAAKRGVDRTITQARRTVEDTTLRARSLGQVGVTGALAQLRLDLRTSMRATQAALYQGVQADASLKESIALFERLSRHGHELDDELKRLEQEPDRKRIAERLPELRERTAKITESADSLRWSARDRARQFADEDLAALSAQIEVESSALRDWSRESVDDLTAAAAAWEAGQGPGAGAGASGAGAGAAASGRASSVPERPALDPSGPAVSYPWQKAPRREATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2S0</accession>
    <name>A0A0F4J2S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_26005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000758">
        <property type="protein sequence ID" value="KJY28149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28149">
        <property type="protein sequence ID" value="KJY28149"/>
        <property type="gene ID" value="VR44_26005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1304"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="9">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY28149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="40082" checksum="37CCCFF1AF7F81CB" modified="2015-06-24" version="1">MLRPLPDTQLVAAQDSVTLDGTTSLPWPAKGQGAVRISGSGDIATFGEQKPVPTASVAKAMTAYVILKNHPLRKDDPGPQIEIDAQAAAESNSDDESRIKHLTVGQKFSQRELLKMVMVPSANNIARLLARWDGGSGGEAAFVAKMNAAARDLGMRDTTYTDPSGLTASTVSTAVDQLKLAEAAMQDEAFRAIVTVTDETIKGVVEPLHNSNDLLWVKGLGNKGIKTGSSTAAGGTLVWAADKSVGGETPMVLGALMDQHADGPDPQALRSLALVLDNSRKVIEAVRKALASTPVVHKGQTVGHVSDGLGGRTPLVATKDLSVIGVPGQKLRLTLGTAGGKPVPHAAAAGTEVGVLTVGEGPGAKTVPVAVGKRLAEPSFGTRVTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J368</accession>
    <name>A0A0F4J368_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000758">
        <property type="protein sequence ID" value="KJY28148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950027.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000758.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28148">
        <property type="protein sequence ID" value="KJY28148"/>
        <property type="gene ID" value="VR44_26000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1303"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19380" checksum="B59DE0649624A0FC" modified="2015-06-24" version="1">MNDNEIDLRPDAPAAGGEVLRFRGQVQENEVRAGLKAAGVFRRVRVPGAAGGAAIALLGALSLADGDPVGLPFVVGGIAYGAVFCLLAPRRITSRGFKAAQAQGERECVVDDGGITVSCPGGEPVRMPWERMKRFHETPEIFAVVGRTGWKTCFFVLPKRLMPAPGQTELVGALLDSRLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3P8</accession>
    <name>A0A0F4J3P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-demethylubiquinone-9 3-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949899.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000730.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28454">
        <property type="protein sequence ID" value="KJY28454"/>
        <property type="gene ID" value="VR44_25315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1160"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18033" checksum="AE23548736D8EC56" modified="2015-06-24" version="1">MTSKGFTTCLWFDGDAEAAADYYLSVFEDGRILRTARYTEAGPGPAGEVMVVEFEINGQRFIGLNGGPQFPFTEAISFQIHCSDEAEADHYYAALTGDGGQESACGWVKDRFGVSWQVIPPGAIDLISDPDPGRAARATAAMLKMKKLDVAAMRRAADGGGAPEEEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4G9</accession>
    <name>A0A0F4J4G9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_26675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27831">
        <property type="protein sequence ID" value="KJY27831"/>
        <property type="gene ID" value="VR44_26675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1494"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="542" mass="56114" checksum="7816194E0BFB030D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5V9</accession>
    <name>A0A0F4J5V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949325.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29747">
        <property type="protein sequence ID" value="KJY29747"/>
        <property type="gene ID" value="VR44_22190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.322"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="694" mass="72598" checksum="B9598E57E18A3AD0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6J7</accession>
    <name>A0A0F4J6J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29408">
        <property type="protein sequence ID" value="KJY29408"/>
        <property type="gene ID" value="VR44_23025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.542"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="7890" checksum="03FD79F56DE4F400" modified="2015-06-24" version="1">MLGQLGQETRKLLDEGIAPAQVRAGLDRHRAKGLHPKTLPSLVHEVMNAGASTPTAAHRPWTNPTDVAAAYGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6T0</accession>
    <name>A0A0F4J6T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29463">
        <property type="protein sequence ID" value="KJY29463"/>
        <property type="gene ID" value="VR44_22860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.506"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10106" checksum="9D33DDE026DD9B58" modified="2015-06-24" version="1">MQVLFVLRGMLYPVVQAGPYTNAWGGPSLAGAWLAHFGVGLLSAVVGLGVLWSLNRLHARLAGGMWGRRVGVWPVLAVAAASAAGMMLVVAWTHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J756</accession>
    <name>A0A0F4J756_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY30000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949184.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30000">
        <property type="protein sequence ID" value="KJY30000"/>
        <property type="gene ID" value="VR44_21455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.169"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12064" checksum="1D2EBA4EB142FBEC" modified="2015-06-24" version="1">MQPALGVDVTTYDHTVVVSVSGELDTDTSPLVARATGTLDLRPGGPALVLDLAGVTFIDAGALNMLLALRHNARAHGTTLRLRAVPAQAQQLLDLTGTRHLFTYCPGPAPGPGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7R4</accession>
    <name>A0A0F4J7R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000687">
        <property type="protein sequence ID" value="KJY28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949663.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000687.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5546"/>
    <dbReference type="EnsemblBacteria" id="KJY28976">
        <property type="protein sequence ID" value="KJY28976"/>
        <property type="gene ID" value="VR44_24020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.796"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="24748" checksum="5DA8B214B053003A" modified="2015-06-24" version="1">MTSDAAAVAAAPAERAAPQAEPAKPLMRGWLHTGMFPAVVVAGLALMAFTDSTRARVACGVYILTACLLFGVSAVYHRGTWGPRGEAILRRLDHANIFLIIAGTYTPLTVLLLPDSTGRTLLWAVWLAAAAGIAFRVFWVGAPRWLYTPCYIAMGWAAVFFLPDFLRTGGIAVLVLVIVGGLLYSAGGVIYGIKRPNPSPRFFGFHEVFHSLTLAAFVAHYVGISLAAYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Z6</accession>
    <name>A0A0F4J7Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29888">
        <property type="protein sequence ID" value="KJY29888"/>
        <property type="gene ID" value="VR44_21710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470202" evidence="2">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="18486" checksum="B10C0474AE022871" modified="2015-06-24" version="1">MVCSLAVGPAATAWAVHAPAAGPSGSECFVEAKAGDAAKATVTGGGFSKARGKVFLKRTDGEGGAVVIVADDGTFSSGDVPAGVYVASQHGGPSVKCVGGQEAQEIVNQKLILSEQTRGTHEGWAQGKKLAESGACDAEAEPPVPNLHGLAPDPEGQKKAEAAYKNAYSAAFDKAIDFYCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J814</accession>
    <name>A0A0F4J814_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LNT_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30522">
        <property type="protein sequence ID" value="KJY30522"/>
        <property type="gene ID" value="VR44_20280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LNT_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9646" checksum="3300121ABD17D583" modified="2015-06-24" version="1" fragment="single">MVAELSGRSGPDGLSRPAGLSQRSRWWRAAGTVAAGAVPCLAFPAPALWWLAYVALVPWMLLLRSAPTGRRAALEGWLGGAGFIVAGHHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8I0</accession>
    <name>A0A0F4J8I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948867.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000545.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30702">
        <property type="protein sequence ID" value="KJY30702"/>
        <property type="gene ID" value="VR44_19725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8564"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470238" evidence="2">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="12821" checksum="6EA924A9D6FEBBE2" modified="2015-06-24" version="1">MTQQTSWTRRLFVFAASTIVAAGSTVLNVAAFAAVHGTPHIAVADHQRQCIKAPCGPADGGSTDGGGPWGGKDGHPHGNPSHHVVECFVAPCGSADGGFPPPNPAPTGKRADVPDDSGMQFQGGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8R9</accession>
    <name>A0A0F4J8R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948933.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30580">
        <property type="protein sequence ID" value="KJY30580"/>
        <property type="gene ID" value="VR44_20080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8638"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="30097" checksum="776D1BDC7DE4FB82" modified="2015-06-24" version="1">MISFLRRLHDRLLASPAGLAWSRGREIELMHRAMGFAALGFLTLVPLLVVVAAAAPGSGSGFGRWLGQALGVTASSRAKVELLFGAADVALERTTAFGLAALAVFGLTFGSAVQTGYEKVWDLPTARWHTMWRHVVWLALLVCYLALLVEIPAPPVKKAGAVLGTISDLVGTCLFFWSSGRLLLGGRVRWAALFPGAVATSVGLLGLRVFSQLVFSPLIASNAVTYGPFGTLLVVQSWLVGVGFVVYGGALMGRLVHEHLTLRRLRSGGVLGSGEVPSHDPGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8S9</accession>
    <name>A0A0F4J8S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000587">
        <property type="protein sequence ID" value="KJY30153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949117.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000587.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30153">
        <property type="protein sequence ID" value="KJY30153"/>
        <property type="gene ID" value="VR44_21100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8943"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="275"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="275"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="40123" checksum="5EF8DA9677B9C286" modified="2015-06-24" version="1">MDDATHGPLAGFTVGVTAARRADELIALLRRRGAAVVHAPALRIVPLSDDGELMAATKELLDDPPDAVVATTAIGFRGWIEAADGWGIGERLLERLRTTELLARGPKVKGAVRAAGLVETWSPQSESLAEVLDRLLAGPVTGRRIALQLHGEPLPGFVEALRDGGAEVVPVPVYRWMPPADLAPLDRLLDAVAVGALDALTFTSAPAAASLLSRAGERGLREAVLAALRGPVLAACVGPVTALPLQGQGVATVQPERFRLGPLVQLLCQELPGRARVLPVAGHRLEIRGHAAVVDGGLRPVPPAGMALLNALARRPGWVVSRADLLRALPGAGRDEHAVETAMARLRAALGVPNLIQTVVKRGYRLSLDPGDGEGWNGGRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J932</accession>
    <name>A0A0F4J932_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_19780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000546">
        <property type="protein sequence ID" value="KJY30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948876.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000546.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30695">
        <property type="protein sequence ID" value="KJY30695"/>
        <property type="gene ID" value="VR44_19780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8575"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="104"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="39085" checksum="54146844E7B20462" modified="2015-06-24" version="1">MSEDSRGSGRAARRRRRRGQPRPRKGLRVAAWTAAGVVLLGGGSLGWFYFKLNGNLHSVDIDSALGKDRPANVDNGSMDILVLGSDSRSGENSEYGQDDGGSARSDTAMIVHLYEGHQKASVVSIPRDTMVPRPACATGKGKTDPGRRKAQFNEAYTIGGPACAVKTVEQLSGIRMDHYMEVDFTGFKKIIDNLGGVQLTTTKPIKDDYSHLDLPPGPHKLNGEQSLGLVRTRKSVGDGSDLGRIQLQQAFIKALIKQVKGVGLFDNPKKLYGLADSATKALTTDKALGDVKSLMGFAQSLQGISAENMHMITLPVGPDPADHDRVVPLAGESKMVWDALLADQPIPAQATEKSAGDKSTAGSIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA97</accession>
    <name>A0A0F4JA97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000517">
        <property type="protein sequence ID" value="KJY31110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31110">
        <property type="protein sequence ID" value="KJY31110"/>
        <property type="gene ID" value="VR44_18870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8387"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="26094" checksum="AA0AA7E7308BE91C" modified="2015-06-24" version="1">MGQKAVRGEGPGGPEGDGTGGERKKLDLSLAQVAGSSLATVAAALLASKLGVYGTILGAGVVSVVATAGGPVIQHAFRRTGDRLREGARPKGGRLPAPARAEGSAAPPPGEFGEATVHGTRVRGWKRTAVASGAAFALAIGGLGTYEAFAGTSVSSGGGTLLSGGTRKAPDHRSAERKDGTDSGGRGGQGGRDGKGGEPGGSGNERSGSGSSPSPSASHGGRGPDPAPTPTPSRSAGPGPDPSPSASRQTPDPGPTPSGGGTGASGGATAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAL8</accession>
    <name>A0A0F4JAL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948818.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30798">
        <property type="protein sequence ID" value="KJY30798"/>
        <property type="gene ID" value="VR44_19440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8497"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470528" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12426" checksum="C2C98033C0306D20" modified="2015-06-24" version="1">MRLRRASIAALGAFTLLLAVPQSASAAIGEFQYSYVGLDGKTHIRALIDPESRECITLPEVADPNASEPAFSPRNRTNATATVFTEAECEGDFFSLRPITGYGTSKLKLRSVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB01</accession>
    <name>A0A0F4JB01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_19145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000526">
        <property type="protein sequence ID" value="KJY30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948761.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000526.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5455"/>
    <dbReference type="EnsemblBacteria" id="KJY30964">
        <property type="protein sequence ID" value="KJY30964"/>
        <property type="gene ID" value="VR44_19145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8435"/>
    <dbReference type="eggNOG" id="COG2142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17688" checksum="88DD8A69CE602425" modified="2015-06-24" version="1">MSSDTSSAQAIGSVEGVSLYDADNPAPYIEAPRKRTGKTPRSTRGNFEMAAWLFMRLSGIVLVVLVIGHLLIQLVLDGGVSKVGFAFVAGRWASPFWQVWDLLMLWLAMLHGANGLRTVINDYAERANTRLWLKGLLYTATVFTILLGTLVIFTFDPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB58</accession>
    <name>A0A0F4JB58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948741.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000522.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31034">
        <property type="protein sequence ID" value="KJY31034"/>
        <property type="gene ID" value="VR44_19035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8411"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="238"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="38854" checksum="E33B45FB4E2B6DBD" modified="2015-06-24" version="1">MNSVQPIPVVVLSGFLGSGKTTVLNHLLAHRGGTRIGVVVNDFGSIEIDAMSVAGQVGDSMVSLGGGCLCCAVDGSELDAYLEKLAAPVHRIDVIVIEASGLAEPQEMVRMLVANENPAVRYGGLVQVVDAAEFDATRAAHPETDRHLAVADLVVLNKTDRVDAAERARIEAEVTALAAPGTPLVGADHGRIDPELLFDRRPWTETRGQLSFEDLLTEAGEHAHEDGEGHAGHAHTAYESLSFTTDQALSPRRFLDFLDRRPAGLYRVKGFVWFGVPGHRERYEVHAVGRFLRFDPGPWGQGEPRRTQLVLIGKGIDAPGLLGELEACREADPGRALPESMWGVLRYVPRPAETGVEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBG7</accession>
    <name>A0A0F4JBG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000485">
        <property type="protein sequence ID" value="KJY31530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31530">
        <property type="protein sequence ID" value="KJY31530"/>
        <property type="gene ID" value="VR44_17920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9493" checksum="15C9F9E6C20D5575" modified="2015-06-24" version="1" fragment="single">MPEPLLEVRDLVKHYPLTQGVLFKKQIGAVKAVDGVSFGLAAGETLGIVGESGCGKSTVARMLVHLERPTAGSISYKGEDITKLSGRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBJ9</accession>
    <name>A0A0F4JBJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948662.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31179">
        <property type="protein sequence ID" value="KJY31179"/>
        <property type="gene ID" value="VR44_18625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8334"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19918" checksum="645F20B6FE7B2182" modified="2015-06-24" version="1">MWGATPGERGAAYPCDDLLGPSAEPWLRAVTVRAPAPVVFRWLCQLKVAPYSYDSLDNFGRRSPRRLTPGAERLETGQRVMTIFELVGFEPDRHLTLLLTTPWAVRAFGEFAITYRADPVDARTTRLVVKMMVGRRPGRLGAARLRMMARGDLFMMRRQLATLGALAERTAARKGAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC51</accession>
    <name>A0A0F4JC51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000467">
        <property type="protein sequence ID" value="KJY31785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948442.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000467.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31785">
        <property type="protein sequence ID" value="KJY31785"/>
        <property type="gene ID" value="VR44_17485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8059"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="480" mass="53866" checksum="12A7BC639482A3C6" modified="2015-06-24" version="1">MPATPRPINVLLVGGCGHWAATENHVPAILTLQRQGFPVRVSAICDPRDPYDENLLRHMPDLLDLLRYDRPQWIRPGQSPEDLERRLDAAHAGQPFDVVIVACDPVAHYPYLYWATRRGIHVLCDKPILAAADAAWDPHAAATIDTHFNILLKAHLDHPGHLFAMPMRRRANDAFVDSSHLITEVYEKHGQALTMANFTVTGGHFRLPEEYGLGNAHGYTHGVGALAFSSYHYIDLMAWYLRLAQGPVTAVRITNHYVRRVGDYLNTGQNRPLEALLRPLSPEPAAAVGLDRRTALAEMDFAFTLELLDDAARAQGYLTYTFTSNSYSHRQVGLQEADRAGHLPFREKGRMSQFVIDLHQGPLQHVRVSKNDVVGDRYRIRLEHRRNPLIDASGGRYADTVYENAHSASTVTPQAMTAEFLRAAAGCPPDELVARRMTYLVGQTFTHRIYAAMYRLIAARHEADTEHRTTTPSLLIDIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCB8</accession>
    <name>A0A0F4JCB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000460">
        <property type="protein sequence ID" value="KJY31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948404.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000460.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31860">
        <property type="protein sequence ID" value="KJY31860"/>
        <property type="gene ID" value="VR44_17260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7986"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="245"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="41708" checksum="56B7E809BB98C537" modified="2015-06-24" version="1">MTTAVPPDARRRALLRTARDVAEDLAADAIARDQAGEPPGDEAARLREAGLPAALTPPRPGRGADWRTGCAVIREISAADSSIGELLARHYVHTWSGRFYADDQQAAALEEESVRGQWLWAGAVNPPAAHEDAGRPDLRLRPRTTGYVLDGHRPLDTAVAAADQIVVDAVCTVTGDVLVVRIPPGARGLGLEPARDRLGQRVAGAGEAVFDRVTVTPGQVLGRRPRDEESAAPFTALAEPALRLALCHVGLGIAEGALVEARDLSRSGRARRLPGEDPDLFLTYGELASAAQTATAVVDRATEVMGQALDAGARLDAEEAAGVAALVATAETVTSKAALHVTARVLEFADAPGLDRFWRNARVLTSQRPVAHRLRSIGEHYLNGSHRAVAAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCQ6</accession>
    <name>A0A0F4JCQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000481">
        <property type="protein sequence ID" value="KJY31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948503.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000481.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31594">
        <property type="protein sequence ID" value="KJY31594"/>
        <property type="gene ID" value="VR44_17800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8103"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10826" checksum="4C355F3BFF2311A4" modified="2015-06-24" version="1" fragment="single">ASVGSVCYTALPDEAYDTLELIDQGGPFPYSQDGIVFQNREQVLPGRTTGYYHEYTVITPGSPTRGARRIVTGQQYQEDYYTADHYATFRRINFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCR5</accession>
    <name>A0A0F4JCR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_17970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31523">
        <property type="protein sequence ID" value="KJY31523"/>
        <property type="gene ID" value="VR44_17970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8139"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="29689" checksum="1548D14E742DCA5B" modified="2015-06-24" version="1">MTQWGEIRHRFLANKLAVVGLGLVLLLFLTAAFAPLIAPQDPLAQDLNNTLQEPGNGHLLGTDALGRDQFSRIIYGTRIAVEIGLASIFLACLIGIVIGALAGYFGRATDSVLMRIADVFFAFPLLIGAIVIIIAMGRGVMPVIISLAVFSWPTVSRLLRSSILSVREADYVLAARALGADTRRIILRHIIPNSIAAVMAYAAFSVGGAIVAEASLSFLGVGVSPEVPEWGNMLAAAKDFMGVKDFLWTYPSIAIVLTVLGFVFVGDGLRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDK9</accession>
    <name>A0A0F4JDK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948392.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000456.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31904">
        <property type="protein sequence ID" value="KJY31904"/>
        <property type="gene ID" value="VR44_17205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7974"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470840" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="6839" checksum="A7113E57DD08629D" modified="2015-06-24" version="1">MRTRLLGFTAALLLAAFGAAVPVAQAVVPAVTGPECVADGVGKVVYDSATGLWICTGGQYDGKPITTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDM0</accession>
    <name>A0A0F4JDM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000420">
        <property type="protein sequence ID" value="KJY32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32310">
        <property type="protein sequence ID" value="KJY32310"/>
        <property type="gene ID" value="VR44_16200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7605"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16073" checksum="534100A2E6087382" modified="2015-06-24" version="1" fragment="single">LAQSRLSPSVHLHTDDFYAAIKQGALAPYLPEAHEQNQTVTGVIARAAAGYAAGGYHTVVDGVIGPWFLGPYKKAAKAAGVGLVYVVLRPDRQTALERGMSRTQHPLTDRQILNQVYDGFADLGPYEKNVLDSTGLTAEETAEAVLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDS7</accession>
    <name>A0A0F4JDS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948142.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7322"/>
    <dbReference type="EnsemblBacteria" id="KJY32487">
        <property type="protein sequence ID" value="KJY32487"/>
        <property type="gene ID" value="VR44_15875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7584"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="96"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="44709" checksum="15FDAF6416DC13CD" modified="2015-06-24" version="1">MALELPRIISVDDHVIEPAHLFDVWLPAKYRDRGPKPLTAGIGELEYTGGKYVISMDPDGPPTDWWIYEDLKFPYKRNIAAVGFDRDDMTLEGITREEMRRGCWDPKARLLDMDLNHVEASLCFPTFPRFCGQTFAEAKDKEVALACVRAYNDWMVEEWCGDSGGRLIPLCIIPLWDIDLAVAEIRRNAARGVRAVTFSEIPTHLGLPSIHSGYWDPFFAVCQETGTVVNMHIGSSSQMPAASPDAPPAVQASLSFNNAMASMMDFLFSGVLVKFPTLKLAYSEGQMGWIPYALERADDVWREHRAWGGVRGLIPEPPSTYYYRQIFCCFFRDKHGIASLDVVGRDNATFETDYPHVDSTFPHTKEVALDHVKGLDDETVHKLMRGNAIRMLGLDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDW4</accession>
    <name>A0A0F4JDW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948352.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31984">
        <property type="protein sequence ID" value="KJY31984"/>
        <property type="gene ID" value="VR44_16995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7928"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470423" evidence="1">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="13322" checksum="1CFCB0EF56E9A850" modified="2015-06-24" version="1">MNLTQPKLRLAATALAAALAVPALTSCDAISTAMDCANTAVAITNGVNNLQQAVSNAGNSVQDTQNALNQIDTDLKKIKDQTGNADLGKAVDSMTTAVKNVRTSVEQGNTAPDIKPVADAAAEISKVCTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE13</accession>
    <name>A0A0F4JE13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000508">
        <property type="protein sequence ID" value="KJY31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31231">
        <property type="protein sequence ID" value="KJY31231"/>
        <property type="gene ID" value="VR44_18580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="16699" checksum="1A290B1D204DBAAB" modified="2015-06-24" version="1" fragment="single">QGGPVRPAYVPPPEPGAPAYGYPQTGHPAAPEGPGTPGYGYLPPVAGGAAGSVADAATQYIAPVPGAAGAPMADAATQYMAPVAGGAAGSVADAATQYMAPVQTGPGAHVAHAATQYVPQVGAAGPAAPYAPPVPPAPAGPGVPGAVLAAAETQAVPSVAGIPAGGVPPYDPPHGGGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE27</accession>
    <name>A0A0F4JE27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31993">
        <property type="protein sequence ID" value="KJY31993"/>
        <property type="gene ID" value="VR44_16950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7920"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="27956" checksum="0959F3D1F6434211" modified="2015-06-24" version="1">MRGYRLIVGMWIRSTMAYRASFLLATFGNAAITVLDFVAITIMFSHVDALGGFTLPETALLYGACSASLGLADLLLGNTDRVGARIRDGSLDTMLVRPVPLLAQVAADRFALRRLGRIAQGLGVLGWALSELDVDWTPGKVLLVPVMVVAGAGIFGGVLVAGAAFQFVAGDAAEVQNSFTYGGCTMLQYPPTVFARELLRGVTFVVPLAFVNWLPALYVLGRPDPLGLPGWVAFLSPLVAFAVFLPASLAWRAGVRSYRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE69</accession>
    <name>A0A0F4JE69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_15865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948140.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32485">
        <property type="protein sequence ID" value="KJY32485"/>
        <property type="gene ID" value="VR44_15865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7582"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="34078" checksum="DFE5B0085D876C9D" modified="2015-06-24" version="1">MDFRLTEDQRDLRAGIRDLLAGRYGREALRESVRASESSGVASSGAVSSGVVSSGAVVDRRLWRELGEAGFFSLRLPESEGGVGLGLPEAVLVFEEAGRALLPGPLVATHLAAGAVPGAASGSAVVTAFDLGGPLVAYLGEADAVLGAEGLPAGEPVRSVDPLTPLWRSSGVLPSGYREAGALLTAALQLGSALRTVELAVRYAGEREQFGQPIGGFQAVKHLCARMLVRAEVARTAVYAAAVTGDAAEIAAAKLLADEAAVRGARDCLQVHGGMGFTWEADVHLHLKRAWVRAEQWHTAPEAEELLAARLGAEAEEEAVAEAEAAAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE80</accession>
    <name>A0A0F4JE80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948269.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32109">
        <property type="protein sequence ID" value="KJY32109"/>
        <property type="gene ID" value="VR44_16535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7739"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="416" mass="44694" checksum="AD3128AC0075414B" modified="2015-06-24" version="1">MSCPIDHTGAVPAAAPITLDPFVTDLDAESAALRAAGPLVRVVLPGGVGVYAVTHHAEARALLTDPRVVKDIGVWGAWQRGEIPLDWPLIGLANPGRSMLTVDGDEHRRLRTLVAQALTARRVEKLRTGIEALTAEALDKLAGLPEGETVDLKAAFAYPLPMNVISELMGVDAAEHPRLKALFEKFFSTQTPPEEVPQMMADLGALFSRIVESKRATPGDDLTSALIAASEDGDHLSTEEITNTLQLMVAAGHETTISLIVNAVVALETHPEQRALVLAGEVPWENVIEETLRWATPTSHVLIRFATEDIEVGDRILPKGEGLIVSFGALGRDEAQHGETAGAFDVTRTPNRHISFGHGPHVCPGAALSRLEAGVALPALYARFPHLSLAVPRAELRNKPVLTQNDLFDLPVRLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEF4</accession>
    <name>A0A0F4JEF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000396">
        <property type="protein sequence ID" value="KJY32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3270"/>
    <dbReference type="EnsemblBacteria" id="KJY32732">
        <property type="protein sequence ID" value="KJY32732"/>
        <property type="gene ID" value="VR44_15345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7471"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="11763" checksum="ED881F6E37F00636" modified="2015-06-24" version="1" fragment="single">MSVTAAQGFTAAGIAAGIKANGNPDLALVVNNGPRLAAAGVFTSNRVKAAPVRWSEQVLRGGTVSAVVLNSGGANACTGPKGFQDTHATAEKVASVLGGEHNAGEIAVASTGLIGVLLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF39</accession>
    <name>A0A0F4JF39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000382">
        <property type="protein sequence ID" value="KJY32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32937">
        <property type="protein sequence ID" value="KJY32937"/>
        <property type="gene ID" value="VR44_14885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="2"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="460"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="879"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="960" mass="103528" checksum="7504928BED913425" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF77</accession>
    <name>A0A0F4JF77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">VR44_14780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947940.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2604"/>
    <dbReference type="EnsemblBacteria" id="KJY32982">
        <property type="protein sequence ID" value="KJY32982"/>
        <property type="gene ID" value="VR44_14780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7352"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="21728" checksum="8039465178A93352" modified="2015-06-24" version="1">MTNLKPYAAGEPSIGGGLGDHVYNRLLGERIIFLGQQVDDEIANKITAQLLLLAADPDKDIYLYINSPGGSVTAGMAIYDTMQYIPNDVITIGMGMAASMGQFLLTGGTPGKRFALPNTDILMHQGSAGIGGTASDIKIQAQYLLRTKQRMAEITAHHSGQTVEAIIRDGDRDRWFTAEEAKEYGLIDEIISAASLVPGGGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFG2</accession>
    <name>A0A0F4JFG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948122.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32539">
        <property type="protein sequence ID" value="KJY32539"/>
        <property type="gene ID" value="VR44_15780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7563"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25676" checksum="60AC82DFD61D4B6F" modified="2015-06-24" version="1">MVLDLVLIGLGIAVFPLPIAAFVLVLSADRGILKGLAFIVAWLACFVAVLAVVLLATGGEPPAPKSPPSTAASALKLAIGVGLIVYGWRRRKAGRRTGEHPGSQEMKETGETKETQETQGAQEAQEAQEASGGMAARLDQISVWTAAGLGPLLQPWGLVAAGAATVVSADLSHAGSFLALFVYCLIATSGLLTMELYTTFAPDSARVRLGRLRTWLQSHQDQALVTVVLVVGLFLVGKSIYQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFN8</accession>
    <name>A0A0F4JFN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948429.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31801">
        <property type="protein sequence ID" value="KJY31801"/>
        <property type="gene ID" value="VR44_17410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8019"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="72"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32546" checksum="C4FAC89DF9E8ABD2" modified="2015-06-24" version="1">MTVAGSTEQAADVREFAARSVGGGLALLSGLVGMVLGAGLIFLGASMAATATKATLIPLGVLVVLASVMAMSGLNTVAPGEARVVQLFGRYRGTIRTDGLRWVNPLTSREKISTRVRNHETAVLKVNDAYGNPIELAAVVVWRVADTARAVFEVEDFTEFVETQTEAAVRHIAIEYPYDAHEEGGLSLRGNAEEITEKLAAELATRVEAAGVEIIESRFTHLAYAPEIASAMLQRQQAGAVVAARKQIVEGAVGMVELALTRLAEEEIVDLDLDPERKASMVSNLMVVLCGDRAATPVINTGTLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI95</accession>
    <name>A0A0F4JI95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_15455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948061.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3292"/>
    <dbReference type="EnsemblBacteria" id="KJY32691">
        <property type="protein sequence ID" value="KJY32691"/>
        <property type="gene ID" value="VR44_15455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7492"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470949" description="Lipoprotein" evidence="6">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="30540" checksum="852C1FDB0BB61A96" modified="2015-06-24" version="1">MRKNIKLTAFAAASAALALGLTACGSSSDPSSTKADGGKADESKPLVIAASPSPHADILNFVKDKLAAKEGLKLEVKEFTDYVLPNTATEQGQVDGNYFQHKPYLDDFNKKNGTHIVPVVNVHLEPLGLYSKKVKALTDIKAGQTIAVPNDTTNEGRALQLLAANKLITLKDGVGTTAKLSDITDKKGLEFKELEAATVPRALNDVDAAVINGNYALEANLSPAKDALVLEKAEGNPYANFLAVKDGKQNDPRVQKLAKLLNSDEVKKFIEEKYQGSVIPAFGTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIS2</accession>
    <name>A0A0F4JIS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34247">
        <property type="protein sequence ID" value="KJY34247"/>
        <property type="gene ID" value="VR44_12290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6442"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26004" checksum="2EEAECD1897DDA25" modified="2015-06-24" version="1">MRGILNPFHAAQRTFRPSRAGIVHDPRVRVLQLWRTVLGLVAWVGLTLTYKGVVSAADVKAAADDRFGQSWSSVLVLVCTFPVVVGAFVAAARGPLRGLYLRRALRPLGSVLAVMASMATFPLAMAPESAGLREAVGLPGKIVIGVLCFWSLGFALYGIGLSLVHVFRTADIHEVLPPLLAGVLVWEMALLDVVTGAYPQVPAAVRTVFILGAPVTVTALSWWELRRLGRRHGLTVRGALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJI5</accession>
    <name>A0A0F4JJI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947894.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33131">
        <property type="protein sequence ID" value="KJY33131"/>
        <property type="gene ID" value="VR44_14495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7159"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6775" checksum="7F60F1EDA0AE93DA" modified="2015-06-24" version="1">MLDTSQGEPTAPVPVAEAPVAEAPAPLGAPEARGCLFALSQPPLMIFLAVIGLLLLLAAVHDLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJN1</accession>
    <name>A0A0F4JJN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000319">
        <property type="protein sequence ID" value="KJY34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34014">
        <property type="protein sequence ID" value="KJY34014"/>
        <property type="gene ID" value="VR44_12805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6642"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470799" evidence="1">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28057" checksum="0958AD954B459EEF" modified="2015-06-24" version="1">MSAMPLALLLTTAAATAVGAAALHAVHGLRKQVSALRDELALPAHARGASVPHARSAVESPAAEIRAAVAAALAEERERELAEARAFWAAQEARDAADAPSLLGGLPGLGEDGPVFLPRQADLVGLEPVLGDDLADEYPEDSAELAAARRRHPSHPDFVPVQPHPGADHERTVSRLEELAEARTALADVRPGPLGTLDVYVFTDGTTLCMTPGHRETAERLAEALRSGTAPVLLGGSGISGAYALTFSCGDAEDPDSNVYILADRVIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJY1</accession>
    <name>A0A0F4JJY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000284">
        <property type="protein sequence ID" value="KJY34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34490">
        <property type="protein sequence ID" value="KJY34490"/>
        <property type="gene ID" value="VR44_11775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="23596" checksum="964FC787AD21FA30" modified="2015-06-24" version="1" fragment="single">MPDPRHHPRDASVLLGAPAHPPRTLLDVFDATAAAHPGAPALDTGDRILDYRGLAAETEALAARLRRAGAGPGDRIGVRVPSGTTELYVAVLAVLRCGAAYVPVDADDPEERAATVFREAGVCLVLGDGDGDGAGIGIGIGIGPGTVPPLGSAYGRPARPIGPGDDAWIIFTSGSTGLPKGVAVSHRSAAAFVDAEAGLFLAGRPLGPGDRVLAGLSVAFDASCEEMWLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL18</accession>
    <name>A0A0F4JL18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34504">
        <property type="protein sequence ID" value="KJY34504"/>
        <property type="gene ID" value="VR44_11680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6302"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7793" checksum="B8810831D6A98252" modified="2015-06-24" version="1">MPYEVFTDRDERALLAAAENRISAPLRIGAALDPVRRLLARYSPVRARRARESLPCQQPNTRPRPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMF2</accession>
    <name>A0A0F4JMF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000215">
        <property type="protein sequence ID" value="KJY35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947062.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7031"/>
    <dbReference type="EnsemblBacteria" id="KJY35532">
        <property type="protein sequence ID" value="KJY35532"/>
        <property type="gene ID" value="VR44_09995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5546"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16777" checksum="40D10BD21AE02AA1" modified="2015-06-24" version="1">MAIDELDGRLIVLLAREPRIGVLEASRRLGVARGTVQARLDRLQANGVIRGFGPQVDPTALGYPVTAFATLEIKQGQGADVRAHLAGVPEVLELHTTTGHGDMLCRLVARSNADLQRVIDRVVGFEGIVRASTAIVMENPVPFRIIPLVEQAAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ23</accession>
    <name>A0A0F4JQ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36457">
        <property type="protein sequence ID" value="KJY36457"/>
        <property type="gene ID" value="VR44_07990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4422"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="435"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="571" mass="58717" checksum="EC36F647793F4644" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ95</accession>
    <name>A0A0F4JQ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inorganic polyphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946846.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36004">
        <property type="protein sequence ID" value="KJY36004"/>
        <property type="gene ID" value="VR44_08835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5013"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="32117" checksum="CBAA4F4019876339" modified="2015-06-24" version="1">MSLAPRAVLVHRRTEYEELIDRHGTHGQAAFFLSSRGRSIDDVVGRHHRTRQALREVAAAVPLTWRTSQVERADLDRFLFAPEDVVVVVGQDGLVANTAKYLAGQPVVGIDTDPGRNPGVLVRHRCTDTAALLRAAAGGGPTEDLTMVEAVADDTQRLLALNEIYLGSPGHQTARYRLGPDGEEGPGEAQASSGVLVGTGTGATGWLRSLWLERGSTAQLPAPSDRRLLWFVREAWPSPATGTTRVGGHLDQREGLRLTVESDRIVVFGDGMEADALQLTWGQSVRLGIAATALRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQJ1</accession>
    <name>A0A0F4JQJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946689.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36445">
        <property type="protein sequence ID" value="KJY36445"/>
        <property type="gene ID" value="VR44_08010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4427"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="22297" checksum="0B862347C9E8FF12" modified="2015-06-24" version="1">MSFFTEGRSLTKGRVRVHQPTDEDKRVQNALISEQYQPCQRIALTTCRDPRVDIECVVEDGYAWMCANWPNRPADPVGWLHSLVRSYARKARKQVPDSWTRKDWYGWRVYAEYFADVADEEVAKGLRVVDEMPESMKRIFEARCVFGYRREVTAELFRVSVDSVGTSDAIARIRAVTDAEAVLAFFAEQMEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQW1</accession>
    <name>A0A0F4JQW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946737.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36239">
        <property type="protein sequence ID" value="KJY36239"/>
        <property type="gene ID" value="VR44_08280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4555"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10663" checksum="1BCD7B0B4530A654" modified="2015-06-24" version="1">MRIFIGGHEAVSTDEFIELALGTPLELWLGVEGESEEERAARLDAARDILAEYPNLPDDVSRVAAQVIAANAPELFNIVPLPPRATARRRNSKGRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR23</accession>
    <name>A0A0F4JR23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947109.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35381">
        <property type="protein sequence ID" value="KJY35381"/>
        <property type="gene ID" value="VR44_10270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5922"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470793" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13116" checksum="96228C4943F35C5C" modified="2015-06-24" version="1">MSKNIAARAAAAAGSLALAATGVLVGAGTASAGSNGQQIAYTDHATPGYRHSIELYGYNNNGEESLGCFNIDSGGTTRISGWWWRGDLTVKAYNSYNCQNSYSWGTHVSVPYSQSGDWTYVTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSE9</accession>
    <name>A0A0F4JSE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_07395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946572.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36683">
        <property type="protein sequence ID" value="KJY36683"/>
        <property type="gene ID" value="VR44_07395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3952"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="772" mass="84460" checksum="7F5E464A154C220E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTN4</accession>
    <name>A0A0F4JTN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_06290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946371.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene69"/>
    <dbReference type="EnsemblBacteria" id="KJY37194">
        <property type="protein sequence ID" value="KJY37194"/>
        <property type="gene ID" value="VR44_06290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3012"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="541" mass="56738" checksum="2715A0C4CC8A8CE5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUD5</accession>
    <name>A0A0F4JUD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylpyrimidine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946055.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37957">
        <property type="protein sequence ID" value="KJY37957"/>
        <property type="gene ID" value="VR44_04610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1003"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470875" evidence="2">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_red" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="22176" checksum="94CAF54D0C364EB8" modified="2015-06-24" version="1">MKLVVVSAGLSSPSSTRLLADRLTAATLEAAAAPARPDAGPEVIELRELATEIAQHFTTGFPSARLAAALDAVAAADALIAVTPVFAGSYSGLFKSFFDLLDKDALTGTPVLLGATGGTARHSLVTEHALRPLFTYLRALVVPTAVYAASEDWGEEGLARRITRAGTELARFLTPHPVTAPATAPRSPTGAVTSLPPSPAAALTPFAQRLAALQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVN5</accession>
    <name>A0A0F4JVN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946110.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000090.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37813">
        <property type="protein sequence ID" value="KJY37813"/>
        <property type="gene ID" value="VR44_04885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1062"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="54"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="28585" checksum="FDCEE3FE6B41FB5F" modified="2015-06-24" version="1">MLTFDTPAPLAVSVEIEVGSVRLTAGERPDTVVEVLPADPGDPEDERAARETRVDHADGTLTVRGARKRLPFGRIGSVEVCIELPAGSRVRAATGVGPLVLDGTFGECVLKSGAGDIRVTAAGPAVLRTGHGDVHLDRCTADAEVHGAGRVRIGRVDGAATVKNVNGDTEIGEVTGDVRANSSNGSITVDRAHGSVEAKSANGAIRVGEVARGKADLQTAVGRIDIGIRGSVAAWLDVTSRMGKVHNSLGASQGPEGSDGVVEVRARTGMGDIVITRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVW5</accession>
    <name>A0A0F4JVW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000062">
        <property type="protein sequence ID" value="KJY38497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945863.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6636"/>
    <dbReference type="EnsemblBacteria" id="KJY38497">
        <property type="protein sequence ID" value="KJY38497"/>
        <property type="gene ID" value="VR44_03495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7918"/>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="161"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="44647" checksum="80C5D896E08FAF1F" modified="2015-06-24" version="1" fragment="single">AHPDRLRLLTAAESAAFLIAAEMHHAGLPWRADVHRALLTELLGERYAGGGEPRRLAQLADEISAAFGRRVRPDLPADVVKAFAEAGIRLRSTRRWELQEVDHPAVAPLLLYKKLYRIYTAHGWSWLADWVHEGRFRPEFVPAGTLTGRWVTHGGGALQIPKVIRRAVVADPGWRLVVADADQMEPRVLAAISRDPAFMEVAGRPEDLYTAVSRQSFSGDREQAKIAVLGAVYGQTSGDGLKNLAALRRRFPRAVAYVDDAARAGEEGRLVRTWLGRTCPPPAGAAEDGEAGIPQDREDEAPGRPPSYASTDTRARGRFTRNFVVQGSAADWALLMLAALRQATAGMRAELVFFQHDEVIVHCPAEEAEAVAEAIRTAGDRAGRIAFGDTPVRFPFTTAVVRCYADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWK6</accession>
    <name>A0A0F4JWK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen regulatory protein P-II 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945936.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38229">
        <property type="protein sequence ID" value="KJY38229"/>
        <property type="gene ID" value="VR44_03920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8689"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12253" checksum="739C49ADE1AB171E" modified="2015-06-24" version="1">MKLITAIVKPYKLDDIKEALHSFGIQGLTVSEASGYGRQRGHTEVYRGAEYTVDLVPKIRIEVLADDDDAEELINVIVSAARTEKIGDGKVWSVPVDSVVRVRTGERGADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWW4</accession>
    <name>A0A0F4JWW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="6" type="ORF">VR44_03965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945944.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene751"/>
    <dbReference type="EnsemblBacteria" id="KJY38238">
        <property type="protein sequence ID" value="KJY38238"/>
        <property type="gene ID" value="VR44_03965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8698"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="21468" checksum="B10A403E289444E3" modified="2015-06-24" version="1">MELVVARVGRAHGIKGEVTVEVRTDEPELRLSPGAVLRTEPASAGPLTIETGRVHSGRLLLRFAGIKDRTAAEALRNTLLIADVDPAELPEEEDEYYDHQLMDLDVVLEDGTEIGRITEISHLPSQDLFIVERPDGSEVMIPFVEEIVAEIDLEEQRCVITPPPGLIDDRAVIASARDAEAEAEAGASPEAEKSGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYE9</accession>
    <name>A0A0F4JYE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ORF">VR44_02695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000044">
        <property type="protein sequence ID" value="KJY38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945719.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1884"/>
    <dbReference type="EnsemblBacteria" id="KJY38874">
        <property type="protein sequence ID" value="KJY38874"/>
        <property type="gene ID" value="VR44_02695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6845"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="554" mass="58160" checksum="1809F178AF3643E0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYX8</accession>
    <name>A0A0F4JYX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945431.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39582">
        <property type="protein sequence ID" value="KJY39582"/>
        <property type="gene ID" value="VR44_01155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2945"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="33181" checksum="E13B16BA1D5BEF81" modified="2015-06-24" version="1">MSDQAPAEYRIEDLAHHSGATVRTIRAYQDRGLLPKPERRGRSNVYRDTHLARLRQIADLLDRGYTLASIKELLEAWDAGRGLGGVLGLVAEVQGPWTDEEADRISREDLNARFGGLPDDGAVDEACELGVLERIPGRPDEFLVPSPQELAVAAELYAAGVPLAAITGHLRELRGQVEHIASRFLEFTTEHVFARYLGQVPPTDSDAAEAATMVRRLRPLAQQTVDAELARAMRLFATRHLQRHLGSPGAVQPAGPAPVPLPAGTVRAVQELVGPEHVAEFVRAATERELQARTMNDLASRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ18</accession>
    <name>A0A0F4JZ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome BD ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_01110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945416.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4722"/>
    <dbReference type="EnsemblBacteria" id="KJY39637">
        <property type="protein sequence ID" value="KJY39637"/>
        <property type="gene ID" value="VR44_01110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2936"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="501" mass="55999" checksum="401C25C3A921C6AE" modified="2015-06-24" version="1">MDLALAPETLARWQFGITTVYHFLFVPLTISLAALTAGLQTAWVRTEKEKYLRATKFWGKLFLINIAMGVVTGIVQEFQFGMNWSDYSRFVGDIFGAPLAFEALIAFFFESTFIGLWIFGWDKLPKKIHLACIWMVSLGTVLSAYFILAANSWMQHPVGYRMNEERGRAELTDFWRVLTQDTALTQFFHTITAAFLVGGAFMVGISAFHLARKKHIPVMRSSLRVGLVVMIIAGMGTALSGDMLGKVMFKQQPMKMAAAEALWDGEAPAPFSVFAYGDVDKGHNKVAIEIPGLLSFLANNDFDSFVPGINDVNKAEQEKFGPGDYRPNIPVAYWGFRWMIGFGMASLGIGVLGLWLTRKRFLLPPGLRTGEDEVPHLVLFKKALSPKFSQLYWLVALWTMCFPLLANSWGWIFTEMGRQPWVVYGVLRTRDAVSPNVSQGEVLTSMIGFTLLYAVLAVIEVRLMVKYVKAGPPELTEADLNPPTKVGGDDKNADRPMAFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ46</accession>
    <name>A0A0F4JZ46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">VR44_00870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945378.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4770"/>
    <dbReference type="EnsemblBacteria" id="KJY39672">
        <property type="protein sequence ID" value="KJY39672"/>
        <property type="gene ID" value="VR44_00870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2883"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25546" checksum="3A5A1AA4C3D7ECB2" modified="2015-06-24" version="1">MTEAAELPPAPEEARAVFGEFFPEAVRYAELLADAGVKRGLIGPREVPRLWERHLLNCAVLSEVVPAGVTVCDVGSGAGLPGIPLALVRRDLKITLLEPLLRRTTFLQEAVELLGLDHVTVVRGRAEEVLGKVQPVHVVTARAVAPLDRLAGWGVPLLRPYGEMLALKGDTAEEELVSAKTALSKLGVVKTSVLHVGEGVVDPMSTVVRVEVGESPGGVRFAAKRAKAARVSRTRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ78</accession>
    <name>A0A0F4JZ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39712">
        <property type="protein sequence ID" value="KJY39712"/>
        <property type="gene ID" value="VR44_00805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2866"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471190" evidence="3">
        <location>
            <begin position="36"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="44967" checksum="BB38A8FC3835D332" modified="2015-06-24" version="1">MKPRLPLQSGLRAVRAALLAGALGAALWPAGSALAAPQPLPEYRVADGARRIAGKPSTADAPLLETGAVYEDVLAPGERVYRLNLDAASSVYVSAVLHPPPGTAAGYGDGLEVEVMTTGGRSCPGNPGRAAFGYDAVPLGAVGQRLLVEDAECQAAGTYYVKVTRSAAGKDSPRAAWPVELQVRREPAPAAGTAPTAAPGAWPSASPVLPGSDPVPRGGGTGFNDARALGAGVWRDELRPGQTRFYRVPLDWGQQLGIGAEIAKARMTKDYGSASDGLTLALYSPYRGPVESRGTSYDGKQAAVTLPRTAPVAYGNRFADEAAVRGVRVAGWYYVAVTLGGKVGEFTEDAAAVPLTLRVAVSGGGSAAAPAYREGLGAAGFGVGEAERSAAREGLTAPEAAAAREDDRSAMRVVAVAGFGAGAVLLLGGWVLLARRSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZK9</accession>
    <name>A0A0F4JZK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945458.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39550">
        <property type="protein sequence ID" value="KJY39550"/>
        <property type="gene ID" value="VR44_01310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2979"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471018" evidence="2">
        <location>
            <begin position="31"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="32443" checksum="9FEF0490CD605F37" modified="2015-06-24" version="1">MNRHRTALSALLAAAALLTGALAAASPSAAADPPSSFRPGQTPGFWTAERMRQATPLDVTASPGGARTAPVPAAPPTRVPPTSPTAFPQAGGAWTGGGAVVKTSGRVFFTFQGRTASCSGDSITSQNGSTVITAGHCVKYQGAWHTNWIFVPGYDNGNAPYGQWAATKTLATDQWAASEDMNMDVGLAVVAPLNGRTLSQTVGAQGIQFNGGYNKKMYSFGFPAAAPYDGTKLVYCSANTGKDFLLTKDHSMSCNMTGGSSGGPWFQDFDESTGLGTQVSVNSFGYNFLPNTMFGPYFGPEAKAAYDKAQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZP2</accession>
    <name>A0A0F4JZP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4709"/>
    <dbReference type="EnsemblBacteria" id="KJY39585">
        <property type="protein sequence ID" value="KJY39585"/>
        <property type="gene ID" value="VR44_01175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2950"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="33547" checksum="3A78E463F14F92C4" modified="2015-06-24" version="1">MTALDRLSLDIGPGVTGLVGANGAGKSTLIKILLGLSPATEGRAAVLGLDVATHGSAIRERVGYMPEHDALPPDVSATEFVVHMARMSGLPPTAARERTADTLRHVGLYEERYRPIGGYSTGMKQRVKLAQALVHDPQLVLLDEPTNGLDPVGRDEMLGLIRRVHTDFGISVLVTSHLLGELERTCDHVVVIDGGKLLRSSSTSDFTQTTTTLAVEVTDSDAHPDGTAALRKALGAAGLTLHAGEEQGLPGAGHILLVEATGEDTYDTIRDTVADLGVGLVRMEQRRHHIAEVFRESDQSAQRIQIQQKGAGTDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K154</accession>
    <name>A0A0F4K154_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">dnaA</name>
        <name evidence="15" type="ORF">VR44_00850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4774"/>
    <dbReference type="EnsemblBacteria" id="KJY39668">
        <property type="protein sequence ID" value="KJY39668"/>
        <property type="gene ID" value="VR44_00850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2876"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="270"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="484"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY39668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="577" mass="64145" checksum="88C75319BB00D5B5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3Z9</accession>
    <name>A0A0F4K3Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39906">
        <property type="protein sequence ID" value="KJY39906"/>
        <property type="gene ID" value="VR44_00130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.24"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20540" checksum="77B7F818B1A4A5AD" modified="2015-06-24" version="1">MSADERRESVIRAAIHEFARGGYYGTSTEAIAKRVGVSQPYLFRLFPGKKAIFQAAAGRCLENTRRAFAEAAEGLHGEEARAAMGEAYIRLIAEQPEMLQMQLQMYVTVAAAEAAGDRELGELVRAGWLELWDTVRIPLGDVQRTTAFMAQGMLINTLSAMGFPSGHRIWDGFPGEVDKAAGSTGGQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K469</accession>
    <name>A0A0F4K469_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional NAD(P)H-hydrate repair enzyme Nnr</fullName>
            <ecNumber evidence="9">4.2.1.136</ecNumber>
            <ecNumber evidence="8">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_00475</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="9"/>
    <dbReference type="EC" id="5.1.99.6" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945306.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39971">
        <property type="protein sequence ID" value="KJY39971"/>
        <property type="gene ID" value="VR44_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="14">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY39971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="38104" checksum="DE8C65088565620D" modified="2015-06-24" version="1" fragment="single">MRTAYSVETVRAAERELMARLPEGALMARAAAGLAAVCAELLAGIRGRVYGARVVLLVGPGDNGGDALYAGARLARRGAGVTAVPMDPERMHPGGLAALRAAGGRVGDSVPRRADLVVDGLLGIGGRGGLRPAAAALAERIPAGAVVVAVDLPSGVDADTGEVSGPAVTADVTVTFGAYKPGLLTDPGASRVGAVRLVDIGLDFGDRAVAMEALQHADVARLLPVPTASSDKYRRGVVGVVAGSEQYPGAAVLAVAGALRGGAGAVRYVGPAAEAVLARFPEVLVGRGRVQSWVVGPGLGAGREAEVGRALADADVPVLVDADGLRGLDAEVVRGRRAATLLTPHAGEAAALLGAPREAVEAGRLGAVRELAGRYGAAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3Y3</accession>
    <name>A0A0F4I3Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantetheine--protein transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001756">
        <property type="protein sequence ID" value="KJY16414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16414">
        <property type="protein sequence ID" value="KJY16414"/>
        <property type="gene ID" value="VR44_40470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10605" checksum="E542835C929069B5" modified="2015-06-24" version="1" fragment="single">EDPSTLHPVRVARQLAKLADPAEPVSGHPTNPLDLEDLPGLGMRVLLVDFDPQGHLTKQLGQQPLPIGGDSLTCHMAGEAKGPLQDLIAPIQHDRLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I713</accession>
    <name>A0A0F4I713_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001748">
        <property type="protein sequence ID" value="KJY16496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16496">
        <property type="protein sequence ID" value="KJY16496"/>
        <property type="gene ID" value="VR44_40440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16495" checksum="2145DE603CD8BA04" modified="2015-06-24" version="1" fragment="single">MTGALLGSPHYMAPEQLSGQTPTHSCDLYALGVSLYELLTGRPLFTADSAYAVIAMHLSTTPEPPSSHRPAIPSDIDNLITSLIAKDPAGRPLTAKDVAARLRTAHLAPGPTPVPAAEASETDEQHLQRAAEAGDSDAMFSLARLLKEADRIDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAU4</accession>
    <name>A0A0F4IAU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001648">
        <property type="protein sequence ID" value="KJY17786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17786">
        <property type="protein sequence ID" value="KJY17786"/>
        <property type="gene ID" value="VR44_39840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="31064" checksum="C2120FE9D8BAC0A2" modified="2015-06-24" version="1" fragment="single">MPAAPQARAPRRSPAAAACVLGGAVAAGLGLGFLAVLVIVLWISSPYPDSGPGGALHLAAGLWLMAHGTELVRYDTLSGVPAPVGVTPLLLVALPVLLMRRAARLGSASGVGVGVGVGAEAEAEEVLPASAVFSAVLCGYLGVGALATLYAAGGPMPADPISAAWHLPLVAVFAAGGGVWAAKGRPAGSLPGWVPGFARRAVARPRYALALRSGAVGVLVLLGGGTVLVGASLVWHAGEVQSAFLTLTGVWSGRFAVLLLAVTLVPNAVVWGAAYGLGPGFAVGTGATATPLGFAGAAALPRFPLLEALPPEGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB21</accession>
    <name>A0A0F4IB21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001580">
        <property type="protein sequence ID" value="KJY18869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952497.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001580.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18869">
        <property type="protein sequence ID" value="KJY18869"/>
        <property type="gene ID" value="VR44_39365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5675"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469872" evidence="2">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="16508" checksum="D094A4CDED704062" modified="2015-06-24" version="1">MHPTKASRLRVLVPSALAVVILSGAAAPAGAADGQGAAAVERKAAAVQQQIERLEEAAESRERVAAGPIDDLLAGLTKTLSDLLNSLTGLLGGIKLPPIEVPKLPEIKLPDIKLPDLPVTVPKLPDLPVTVPAVPATPAVPGVTPAVPTVPDVQIPDIPISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJX0</accession>
    <name>A0A0F4IJX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001426">
        <property type="protein sequence ID" value="KJY22307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22307">
        <property type="protein sequence ID" value="KJY22307"/>
        <property type="gene ID" value="VR44_37970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5158"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025335">
        <property type="entry name" value="DUF4241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14025">
        <property type="entry name" value="DUF4241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="49121" checksum="D9DA043D44828CB6" modified="2015-06-24" version="1">MHPTVDRSGTVGEARAQEGAVVVVEVGYAQGWDPESRAVWRTLSVGEARERDAAGLPYVVVYRTAGRHSPLEVRLVSWRDHHVGLWVYDDMGRRTYDLDLRLLDDPARLFHRYSVAWHYPDQETAEFDPKGPRVILDLFPDGRGRRREEPRGYATSADLREAQRWVDRPAFGEWPLLSARVHGFTEPPVFEAAEVADGDGGEAPASCWRPPRPAQPGRIGELFRPGVRVTDGYHPEQTVVEPRRVGTVHVPSGLLAISGLFTDHENGPHITVPIPPGEYVLDEARVAYGYHCEWRDAEVETTDPTAVRLLLSETPAASWEMALGADDDLRIFIEKQIAGFDTDGATGCFADAGSFESLLSLFERGLIDGEPDLHGYEDLTDGSMFIHRTWDSATGGELMAFATTGDGAYPVWLGRSEAGELVSVVVLIEGMPQVLPERDGATADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM80</accession>
    <name>A0A0F4IM80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001445">
        <property type="protein sequence ID" value="KJY21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21731">
        <property type="protein sequence ID" value="KJY21731"/>
        <property type="gene ID" value="VR44_38180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470217" evidence="1">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="8661" checksum="03C4454497657A64" modified="2015-06-24" version="1" fragment="single">MRVRSWKLRLGLVVSTTLLGAGALAPIASAAPAVQPAQVLAGHHGSGSGNSLGKFLGGSGSGTGGVKIGHGSVRVGDNVCAGRCNGTVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IML9</accession>
    <name>A0A0F4IML9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001411">
        <property type="protein sequence ID" value="KJY22733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952201.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001411.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22733">
        <property type="protein sequence ID" value="KJY22733"/>
        <property type="gene ID" value="VR44_37795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5117"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469958" evidence="1">
        <location>
            <begin position="36"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="44549" checksum="7C0BE3299249F1CE" modified="2015-06-24" version="1">MPLSANRRPLNRRLAVGAALLAVVAGAAPVTAAHAAGAPSPEALRATGPALPAPDMEAVDQALRNTLAAGAPGALARISEGGRALSATEGVSDKVTGAAMDTRARFRIGSVTKTFSTVVLLQLVDEKKIELDTPVNHYLPGLLPDDRITVRHLLTHRSGLSDYTNAMFDKTVPGFEAVRNKVFTYRELVDLSLAEPRTGEPGAAYQYSNTNFVVVGMLIEKATGKPVAKEYERRIIKPLKLRDTSYVHPGTQIAGLHTHGYLTPDEAGAPLVDSTEQTVSWAQSAGAMISSPADLSTFMSALVGGRLVAPQLLDQMLTMTPTDAAGTRFYGLGLRRYDLSCGTSVYGHTGTVQGFYTYAFTTRDGRRSVTAMANTSNRGVANTALGATLEGAFCGKKPAAAAQARGFASAPADVDLPERHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP43</accession>
    <name>A0A0F4IP43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001357">
        <property type="protein sequence ID" value="KJY23805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952092.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001357.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3091"/>
    <dbReference type="EnsemblBacteria" id="KJY23805">
        <property type="protein sequence ID" value="KJY23805"/>
        <property type="gene ID" value="VR44_37195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4830"/>
    <dbReference type="eggNOG" id="ENOG5032YDP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="12508" checksum="41AF73663148298E" modified="2015-06-24" version="1">MSPRHNRPRGGETPDERPSSSYDRYGLERTEEYLGEEWKVRHVAGASAAGKRYRCPGCDQEIPSGTPHVVAWPEYGGVDDRRHWHKACWNAKDRRTSKVQRSRNAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPM2</accession>
    <name>A0A0F4IPM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001319">
        <property type="protein sequence ID" value="KJY23975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951999.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001319.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23975">
        <property type="protein sequence ID" value="KJY23975"/>
        <property type="gene ID" value="VR44_36700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4649"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="26897" checksum="D04C8B6D45185271" modified="2015-06-24" version="1">MSSPRHLPFARLHNFRDLGGYRSADGRTTAWGVLYRADSLGKLDPADADWDRFLGLGIRTVIDLRYPWEIEAKGRIPEVERFTYANLSIEHRPYDQATIDPALDPWRYLADRFAEVAEDGVEEIRGAIELIADGPGPAVFHCTSGKDRTGLIAALVLTLLGVDEEQILADFALTELATARLTADWHAANPGRPLLWPSYGRAPATVMALVLADLTARHGSPSAYLTDAVGVAPGTIGRLRERLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPR9</accession>
    <name>A0A0F4IPR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_36625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001314">
        <property type="protein sequence ID" value="KJY23997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951983.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001314.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23997">
        <property type="protein sequence ID" value="KJY23997"/>
        <property type="gene ID" value="VR44_36625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4634"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="11324" checksum="C1A7BF21F8EF91E5" modified="2015-06-24" version="1">MPSEPLSQKEIEDRLRELPGWAFEDDRILRTYRVATHRAASALVAHIAVVQDELNHHSDLTLGYDTVRLAVNSHDAGGRVTENDFALAERVEALALAPAHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ27</accession>
    <name>A0A0F4IQ27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kbl</name>
        <name evidence="3" type="ORF">VR44_36245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001286">
        <property type="protein sequence ID" value="KJY24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951913.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001286.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1575"/>
    <dbReference type="EnsemblBacteria" id="KJY24130">
        <property type="protein sequence ID" value="KJY24130"/>
        <property type="gene ID" value="VR44_36245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4495"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="244"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="42647" checksum="7EC9F2C1FFFE4CD1" modified="2015-06-24" version="1">MFESVREDLRATLAEIRAAGLHKPERVIGTPQNAAVAVTAGGAPGEVLNFCANNYLGLADHPEVVAAAKDALDRWGYGMASVRFICGTQEVHKELEARLSAFLGQEDTILYSSCFDANGGVFETLLGAEDAVISDALNHASIIDGIRLSKARRFRYANRDMADLEAQLKTATEGGARRKLIVTDGVFSMDGYVAPLTEICDLADRYDAMVMVDDSHAVGFVGPGGRGTPELHGVMDRIDIITGTLGKALGGASGGYVAARAEIVELLRQRSRPYLFSNSLAPVIAAASLKVLDLLESAGDLRDRLAANTKLFRAKMTEAGFEILPGDHAIAPVMIGDAAEAARMAELLLERGVYVIGFSYPVVPMGQARIRVQLSAAHSTADVERAVAAFVDARAALSAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ43</accession>
    <name>A0A0F4IQ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001283">
        <property type="protein sequence ID" value="KJY24145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951910.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001283.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3764"/>
    <dbReference type="EnsemblBacteria" id="KJY24145">
        <property type="protein sequence ID" value="KJY24145"/>
        <property type="gene ID" value="VR44_36230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4490"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20795" checksum="509E602E388BA1AA" modified="2015-06-24" version="1">MRVNFTVNGRPQEADDVWEGESLLYVLRERLGLPGSKNACEQGECGSCTVRLDGVPVCSCLVAAGQVEGRDVVTVEGLADFAKQREEHGHACGTGACGGGKGVSTDEAKQWSAKGTDSQTGEGVELSNIQQAFIDAGAVQCGFCTPGLLVQADALLESNSSPSDQDIREALSGNLCRCTGYEKILDAVRLAAARQGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQB3</accession>
    <name>A0A0F4IQB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001268">
        <property type="protein sequence ID" value="KJY24215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951865.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001268.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24215">
        <property type="protein sequence ID" value="KJY24215"/>
        <property type="gene ID" value="VR44_35995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4357"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12797" checksum="496A497DD12305F8" modified="2015-06-24" version="1">MGFQDGAGVLRIGDTVVPLEIAASYRARTRGLLGRDGVEGALLLSPAASVHTFRMRFPIDVAHLDRRLRVIAVTTMPPNRLGLPRPRSRHVLEAEAGAMARWGLRVGTAVSLERLGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQJ1</accession>
    <name>A0A0F4IQJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001331">
        <property type="protein sequence ID" value="KJY23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952031.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001331.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23919">
        <property type="protein sequence ID" value="KJY23919"/>
        <property type="gene ID" value="VR44_36870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4687"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21797" checksum="B75A13CFC2C3E183" modified="2015-06-24" version="1">MSDPHDPHGPRDDDYSATVLGSHWFSGPPPPADAAPDRVEGAVLRFGPGVTAALPAPFPVTPVPVPPPPRRRGGGWRRYTLAAVVLAGVLAYLGWQRFGPAVQVREVAVSTEPGGPGCDATADVVATVRTDGRPGTLTYRWIRSDGTRSEELTERVPSGRTEATLHLMWTFRGTGTYPARAELQLLSPAERTAATEFTYTCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR07</accession>
    <name>A0A0F4IR07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_35315</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001226">
        <property type="protein sequence ID" value="KJY24450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951737.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001226.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24450">
        <property type="protein sequence ID" value="KJY24450"/>
        <property type="gene ID" value="VR44_35315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4175"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY24450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="28748" checksum="3B32A22608E3B985" modified="2015-06-24" version="1">MVHQGGRSERRISSVFLGIVAVMAVTGWAVWTGYATSPGLAVFLFVTSAWVVSLCLHEYAHARTALHGGDITVGAKGYLTLNPLKYTHALLSIVLPVVFVILGGLGLPGGAVYIERDRIRGRWRHSLVSAAGPLTNVAFAVICTAPFWLDALDGVPLSFRFALAFLALLQVSAAILNFLPVPGLDGYGVIEPWLSHRARRELAPLAPFALIGVFALLWIPEVNAVFFDAVRGVLRALGVSDLETYCGRALYRFWTEQDGFCAVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRG5</accession>
    <name>A0A0F4IRG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001301">
        <property type="protein sequence ID" value="KJY24063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24063">
        <property type="protein sequence ID" value="KJY24063"/>
        <property type="gene ID" value="VR44_36420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="716" mass="76253" checksum="D1BB859FDAB2419A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRS8</accession>
    <name>A0A0F4IRS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001181">
        <property type="protein sequence ID" value="KJY24697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24697">
        <property type="protein sequence ID" value="KJY24697"/>
        <property type="gene ID" value="VR44_34570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3899"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15795" checksum="8142B890ACE50458" modified="2015-06-24" version="1">MADPQGQGFEPATGDGAEPSGAGRAAELRTAYEGLLQIRRLLTGGERGPAPWELRMMPRAVALVLEAAGFPPSAVDPAGRRSRTGYRVAPGARGLVEVTWAGPPGSGAAGEEAERLAACAEELERHGWDCLVYRGPRGRRFLEVGAPHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT50</accession>
    <name>A0A0F4IT50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_36990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001340">
        <property type="protein sequence ID" value="KJY23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952053.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001340.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.032"/>
    <dbReference type="EnsemblBacteria" id="KJY23881">
        <property type="protein sequence ID" value="KJY23881"/>
        <property type="gene ID" value="VR44_36990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4782"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470384" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="28"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="54"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="315"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="471" mass="50700" checksum="8A0F273E72234BB3" modified="2015-06-24" version="1">MELRTLTRLAAPALAVLLALTTGCTGATVQGRPGASGLRDPYFPRAGNGGYQVEHYALDLAYDPADGELRGTAVITARAGQGLSSFNLDFSGLKVEGVDVQGVAARFNRTGNELTVRPAKDVRKGEVFRTRVDYAGRPKALVDPDGSKEGWITAEGGFAAGVGEPVGSMGWFPGNHHPSDKATYDVTVTVPAGYEAVSNGELRSRRDVGGGRTEFAWRSAEPMASYLATVAVGKFKVSTGRTASGVSVYQAVAPAEEEASRAVLARVPEMVEWGSATFGPYPFGTVGSIVMPARSLGYALETQTKPVYPGAPDEELVLHELAHQWFGDSVSPKSWKDMWLNEGFATYAEWLWAETHGGVSAQRRFEAFLAGDTSVDAHAGVDWAAFPPASPPGAEHISDDPVYYRGAMVLHRIRQEVGDEKFFGLLRGWAADHRYGNASTADFTAYAERRTGADLKKVWDVWLYGDERPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITG4</accession>
    <name>A0A0F4ITG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001171">
        <property type="protein sequence ID" value="KJY24773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951559.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001171.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24773">
        <property type="protein sequence ID" value="KJY24773"/>
        <property type="gene ID" value="VR44_34340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3845"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="41077" checksum="CE4FF7274AC85D0F" modified="2015-06-24" version="1">MSVADGTLPPVSSYPPSGPPQTTTLRQRLADLRGPAVPPRPLDARALAALAANPGCGRRALLDGAGVDKTALAAALGTPAAFGQSQFAIVRGNSFEAKVKGDGGAELLRLVHARLGAGAEPPGSDARVPDLTAAGPEGRAARTALALREATAARTWTLLDHPMLALEVAGTPAYLEPDAVVVHPDGRWTVVEIKSFPMIDGAADAAKVGAAARQAAVYVLALEQTAAKLSGAEVGHRVLLVCPKDFSNLPTAEPVDVRRERAVTRRQLDRLTRIEDLAAGLPEGLCFDPSRTAEELTEAVSAVSAAYAPECLAACELAFHCRERSRAAGDPAALGRSVRGELGGLGSIEEALAAASGAGPDGDPTAEALHQAARLRAEALELAAARPPYQAPETPECPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITT1</accession>
    <name>A0A0F4ITT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001129">
        <property type="protein sequence ID" value="KJY25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951429.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001129.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25049">
        <property type="protein sequence ID" value="KJY25049"/>
        <property type="gene ID" value="VR44_33625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3632"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="348" mass="39164" checksum="DA7FAECCB6B522C2" modified="2015-06-24" version="1">MKFLAITLIADSADPVTGVPTPTRERFREVVAAAELAESLGFDGFGVGERHERPFLSSSPPVVLSHIAALTRRIRLFTAVTTLSLLDPVRAYEDYATLDHLCDGRLELMIGKGNGTAQRELFHVTPEDQWERNTEGYELFRRIWREEEVTAEPRFRPALTKAEVLPRPYQRAVRVWHGSATSRESVDLAARYGDPLFSANVTHPIGPYAELIRHYRERWEHYGHDPAHAVVGAGTAGYHAAPTSQQAALAYRPAFARYLDTHRRQGLDPVFPTLEDFIERSSALIGSPQQVIEKVHRYHEEFGHTVLHLQAEPGGLTAAEHRASLELFQSDIAPVLRREIPDPSFPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITY4</accession>
    <name>A0A0F4ITY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951203.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25470">
        <property type="protein sequence ID" value="KJY25470"/>
        <property type="gene ID" value="VR44_32405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3284"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16215" checksum="14F875EA194150AE" modified="2015-06-24" version="1">MCKPEWGRARVRAQRLAELTRLRRVRDRIDREFARPLDVEALAREVNMSAGQLSRQFRAAYGESPYGYLMKRRIERATVLLGRGGLAVTEVCSAVGCASPGAFTSRFTELVGVPPGAFVAGRVPGPVRNRVPGPVRNREAPAAARLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUB1</accession>
    <name>A0A0F4IUB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001126">
        <property type="protein sequence ID" value="KJY25063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951420.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001126.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5677"/>
    <dbReference type="EnsemblBacteria" id="KJY25063">
        <property type="protein sequence ID" value="KJY25063"/>
        <property type="gene ID" value="VR44_33565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3595"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="38242" checksum="DC84292AB2CE5603" modified="2015-06-24" version="1">MSESELDLTLDAAGLTARLVDIPSVSGDEKVLADLVEDALRRLPHLTVDRHGNNVVARTHLGRAERVVLAGHLDTVPIAANVPSRLDENDVLWGCGTTDMKSGVAVQLRIAATVPEPNRDLTFVFYDQEEVAADLNGLGKVAAAHPDWLAGDFAVLLEPSNAEVEGGCQGTLRVLLHTRGERAHSARSWMGSNAIHAASPILAKLAAYEPRKPVIDGLEYHEGLNAVRIEGGVANNVIPDACTVTVNFRYAPDRSEADALAHVKEVFADCGVDAFTVDDSSPGALPGLSHPAAAAFMEAVGGHAMPKFGWTDVSRFSALGVPAVNYGPGDALLAHKVDERVETKAILHCEERLRAWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUW2</accession>
    <name>A0A0F4IUW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_31530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951039.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3661"/>
    <dbReference type="EnsemblBacteria" id="KJY25820">
        <property type="protein sequence ID" value="KJY25820"/>
        <property type="gene ID" value="VR44_31530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2801"/>
    <dbReference type="eggNOG" id="COG1953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="510" mass="54527" checksum="7A46B1C956548A93" modified="2015-06-24" version="1">MPDRPRTETGDRVELAPGEVPSDGRFANPDLLPVPVADRRWTTYNFTALWVGMAHNIPSWLLASGLVALGMDWKQAVFTIALANLIVLVPMLLTGHAGPKYGIPFPVLARAPFGVRGANMAALIRAAVACCWFGIQTWIGGSGIFVLLGKIFGGWAGAAEIGGEPWTLWLCFIVFWALELAIIHRGMEALRRFENWAAPFVIVGALTLLVWIGVKAGGFGELLDQPSRLGWGADFWAVFFPALMGMIAFWSTLSLNIPDFTRFGAGQRSQILGQTLGLPTTMTLFALLSVFVTSGSEAVYGTAVWDPVELVAKTDSVFGLLFALVTVLVATISVNIAANVVSPAYDLANLAPRLIDFRRGALITGVVGVLIMPWKLTSTPELYIFTWLGLVGGLLGTVAGVLIADYWLVRRTRLSLPDLYREGGPYWYTGGWNLRALAAFVVGGVLAIGGSHSAPGKGPFPEAGLIPFLKPLADYGWVVGLAASLLLYTALMTGSHPAAPEAGGAHGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX1</accession>
    <name>A0A0F4IUX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951036.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25817">
        <property type="protein sequence ID" value="KJY25817"/>
        <property type="gene ID" value="VR44_31515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2798"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="39608" checksum="081CF83F878D358C" modified="2015-06-24" version="1">MNDAITAAWRRAAGHQRRFDARFATYLDALTDPASSSLEIPRHGTFPARALQLVRELSLRGGKRLRVTLLHEAAALVTDGSVPGLDEAAISIELLQTHGLIHDDIIDDAPTRRGGPSTYYAYRQDFPDRPGTALALAVLAGDLAAFLAGRVLLTGALPPDRALAMAAVQADAAAATVAGQLLDLERDFHPAPDIELLHEVTEYKSTRYSILAPLRLGLLAAGADLAPHDAELRRYATALGIANQIHDDWLDLFGDPESLGKPVGSDIRSGRRSYVVRALLAVCDTGERKLLDAALGAPDCEADTLDRIRDIARAHGIDRQLRADAERYARQAAARTATWRERWRPDAVAFFEHMPAWSVTRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX5</accession>
    <name>A0A0F4IUX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951041.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25822">
        <property type="protein sequence ID" value="KJY25822"/>
        <property type="gene ID" value="VR44_31535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2803"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="40"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="25329" checksum="588B0EEA114C955C" modified="2015-06-24" version="1">MGGSRAVAAPAARRRVGAVGPRPPASLLGREIRRLPTSRRVVALTFNAAWDESGLAAVLAELRRRKAPATFFPTGEYAEARPAAVRAMAEAGHGLGNHSYSHPYFDGLSTRERAREVREADEAIRTASRVEPLPFFRFPYSSTTQDAVADVNDLGYAAIEFTNDTNGYLGPAGGMTVDRVVRRAVDSLGPGAILQMHVGSSTGDGVVLDAQALPRIIDAALEEDCAIVDLREFLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW61</accession>
    <name>A0A0F4IW61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000963">
        <property type="protein sequence ID" value="KJY26252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950860.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000963.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26252">
        <property type="protein sequence ID" value="KJY26252"/>
        <property type="gene ID" value="VR44_30565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2528"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7597" checksum="25AF567A5B7C590D" modified="2015-06-24" version="1">MPRTLPRRIPQVTIGQQSQSWLLPVLVAVLMGGGGSQLPLDAWIRLSTLIALVVVVLVIAARASLTRVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWM0</accession>
    <name>A0A0F4IWM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001125">
        <property type="protein sequence ID" value="KJY25071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951415.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001125.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5685"/>
    <dbReference type="EnsemblBacteria" id="KJY25071">
        <property type="protein sequence ID" value="KJY25071"/>
        <property type="gene ID" value="VR44_33535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3587"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23600" checksum="793C1DF47EEFA880" modified="2015-06-24" version="1">MRQLWGQERVITGNRQTSWAFADAFVAEDDALRWARDRSREAGLRSVSPGTGAALRLLAATADAKAVAEIGTGTGVSGIHLLHGMRPDGVLTTVDPEADRQAFARQAFRAAGFAGNRARFIPGRALDVLPRLADGGYDLVFCDGDPTESLDYLAESLRLLRPGGLVCFEGVFSDGRTVDSAAQPVEVLRVRELLRSVRESPALKSALLPVGDGLLCAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWT7</accession>
    <name>A0A0F4IWT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000936">
        <property type="protein sequence ID" value="KJY26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26472">
        <property type="protein sequence ID" value="KJY26472"/>
        <property type="gene ID" value="VR44_30010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="41830" checksum="9D7663520E441818" modified="2015-06-24" version="1" fragment="single">MVRQGSASEGSGKAAETSGAGAGDSGSEAGGDEPSAAARAERTAVFRAVRPGSAGADSAREAEAKPKNGSASAGSGGTRTTAFGAATSDPAPEDGRPEPAAGADSASGRAASADAGKPSAGPAAASERTAVFGTVKPASAPADSAKDAGEDRPADAKPGSGSGSGSGGSRTTAFGVVTSDPAPQDADARPERGSGGAPADPRGRESSERTAVFRTVKPGSADAGERSPAGSEQGSTASPAGSGERTAVFRTVKPGTRPAPDAPAGQDPRAAAGTDERTAVSRAEKPGSAPADAKGSAPAAPGKSSESGKDAESGKAADARDPRAAAGAGSDERTAVFRAVKPGSAPADAKGSAPAAPGKPAAPAKDAEPGEDSERTAVFRAVKPGSAPAGAGKGAPGKPADADPKPGAPKAAPAPEARVSKFVPLGDEPPKPPAPRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXE3</accession>
    <name>A0A0F4IXE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">VR44_30835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000980">
        <property type="protein sequence ID" value="KJY26118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950913.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000980.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5944"/>
    <dbReference type="EnsemblBacteria" id="KJY26118">
        <property type="protein sequence ID" value="KJY26118"/>
        <property type="gene ID" value="VR44_30835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2624"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="307"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="550" mass="60189" checksum="E9DFD0FFA8194E36" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXL8</accession>
    <name>A0A0F4IXL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000943">
        <property type="protein sequence ID" value="KJY26404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950784.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000943.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26404">
        <property type="protein sequence ID" value="KJY26404"/>
        <property type="gene ID" value="VR44_30120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2428"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20196" checksum="6C22C4071F34AACF" modified="2015-06-24" version="1" fragment="single">LADPAAFDSLPAAVDILVNSAGLQHVAAIEEFPPERFELIQRVMVHAPFLLLRRVLPHMYGRGWGRVVNISSVHGLRASAFKSGYVAAKHALEGLSKVTALEGAPHGVTSNCVNPGYVRTPLVERQIAAQAEAHGIPAERVVEEVLLRGSAIKRLIEPEEVAAVAVWLCGPHTGHVTGASLPMDGGWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0D1</accession>
    <name>A0A0F4J0D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000804">
        <property type="protein sequence ID" value="KJY27722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27722">
        <property type="protein sequence ID" value="KJY27722"/>
        <property type="gene ID" value="VR44_26930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1547"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="30864" checksum="16FCE0F7FAE26E57" modified="2015-06-24" version="1">MRGMGLTEQLVHPNPRQRADAARRVSGAVWDPGAEAELAGVLVEAACAEEDPGALEAQLGALVAVEAGISDLGLQRLGLLWPAPPVLERLLARAGRLQVSAPVTPGGPATLAVVRCLRGTPRTGSRLRTPDGAWVVLERIELYGRAVDRLDAGSTARVLLSGAGARGLEEWDRLEADPRARECVRRLRDPDPRVRCLAAEEAADRPDAWDGDDGRRLCAALARAAVAETDPEARQGELHALLRLGYFVSAPVLVLLRGLERGLVAPSLRPYLDDLLDERPPGDRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0X8</accession>
    <name>A0A0F4J0X8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950712.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26571">
        <property type="protein sequence ID" value="KJY26571"/>
        <property type="gene ID" value="VR44_29720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2321"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="21893" checksum="2BD91805FD14D7E2" modified="2015-06-24" version="1">MTRSTAAHPQMSLKDFETLARRAPETVTLEFINGKLEVKSVPDGDHDEIIMWVADQCMAHRPDLRLYRERGLRTEQYRNGRARPDGALAPQRHFAGHGEWSDPAGVLMTVEVTSHDHDTEARDRQEKRDGYAQADIPVFLLIDRDSDTITVYSQPENGRYRRRESCPYGETIALPEPVGFSLDTEALKDYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J168</accession>
    <name>A0A0F4J168_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000813">
        <property type="protein sequence ID" value="KJY27619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27619">
        <property type="protein sequence ID" value="KJY27619"/>
        <property type="gene ID" value="VR44_27195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1628"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12193" checksum="F46CAACB66C03CB6" modified="2015-06-24" version="1" fragment="single">GKSVVGGVSRIDVRPDGSGCDTVWESAIRSPSVVPKLSAGNGLLYFYEKEPNSWGIDAWYLTAVDFRTGERRWRQLTGTGPLYDNNWAPITLGPDGTAYVGVFNGIVAVRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2V0</accession>
    <name>A0A0F4J2V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000755">
        <property type="protein sequence ID" value="KJY28179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4J2V0"/>
    <dbReference type="EnsemblBacteria" id="KJY28179">
        <property type="protein sequence ID" value="KJY28179"/>
        <property type="gene ID" value="VR44_25970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470079" evidence="1">
        <location>
            <begin position="27"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="528" mass="55971" checksum="ADBF181B78D73479" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J337</accession>
    <name>A0A0F4J337_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000712">
        <property type="protein sequence ID" value="KJY28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28650">
        <property type="protein sequence ID" value="KJY28650"/>
        <property type="gene ID" value="VR44_24895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.979"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7855" checksum="EDEE19F7CB600538" modified="2015-06-24" version="1" fragment="single">AWAEDPDRPVWLQEVGAPAPLVPPEHAAEFAEATLAAALDCPGLWGVTWWCSHDVSRELADFPELEYGLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3K3</accession>
    <name>A0A0F4J3K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949965.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28288">
        <property type="protein sequence ID" value="KJY28288"/>
        <property type="gene ID" value="VR44_25670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1233"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="14611" checksum="FAF5E9E010AD1978" modified="2015-06-24" version="1">MTFEFEAEWARAKGEAAMRLASAGPLPAPTPQPSPSASPHAADADLGLVHDPVRSKASAMRTANAEARGKSTLDDAEAVGRVHSGWAAGPASNDCVGAWQRRLRELADLVDGAADALTKGANAITGEDAAIGASLRAAGGVLGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3K4</accession>
    <name>A0A0F4J3K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome B561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_27400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000829">
        <property type="protein sequence ID" value="KJY27491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950292.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000829.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27491">
        <property type="protein sequence ID" value="KJY27491"/>
        <property type="gene ID" value="VR44_27400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1647"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34183" checksum="C455AE6DB92678FB" modified="2015-06-24" version="1">MGAVLNPFAYLAARWTPSPRIVQRAAAIAVLMSVLIVVTGGAVRLTGSGLGCDTWPKCTDDSLIVTQAQGFHGAVEFGNRMLTYVLCAAVGAVILTARSAKPWRHSLTRLGWTQFALVMGNAVLGGITVLTGLNPYSVAGHFLLATSLLAVTTITWQRTREGDGAPRPRVPGPVRKLSWALIATTLVLIAAGTVVTGSGPHAGDKSEIKRMPFDWATTAHVHAIAAWLVCALGVAMWLVLRVVDAPADTRARARDLLLVLLAQGAIGYVQFFTSLPEVLVAVHMLGSCLVWISVLRLALSLRERSAEPAQTPAREDAELSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3P5</accession>
    <name>A0A0F4J3P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000689">
        <property type="protein sequence ID" value="KJY28952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949670.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000689.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28952">
        <property type="protein sequence ID" value="KJY28952"/>
        <property type="gene ID" value="VR44_24080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.810"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="30072" checksum="DE37B48455A4CCBA" modified="2015-06-24" version="1">MQIGVNVTSPDTLEMACELRDSGHIDFVEVLIDGFAHLDPKEFRRTVGDDLPVGCHIMLSRFLDPDRERLDHYLDLVNRWRADCGLLYVSDHIAHFSHNGQPLPLAQEVDYAAWQPVVDSVRAWQEELGTSLAVENFPSQTPSDVPQARAYAELTAATGCEVLMDVSNAMVAQLNTGQPAAAWADVPGVGRRFHLAGYSPSPTAPSLIVDSHDAAVSDETLDLLTLFAGRAAPDATLVVERDANHDLDEWRTDLDRTRAAVVAARRLHQPHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Y1</accession>
    <name>A0A0F4J4Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000655">
        <property type="protein sequence ID" value="KJY29315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949518.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000655.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29315">
        <property type="protein sequence ID" value="KJY29315"/>
        <property type="gene ID" value="VR44_23265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.593"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="191"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="373" mass="38990" checksum="74BEB65FC483C2EA" modified="2015-06-24" version="1">MKILHAVTLHSPSHAFGGPVRVALNLAKGLRERGHEARLLALGEGFDPWPTSVEGVPAKLFPARRLLPLGFSGMTSPALLASASRLVRDADVVHVHLARDLVTLPVALAALRAGKPLVLQTHGMVDPSEKLLAKVLDAVAVRRLLRGADALLYLTPHERTGLDAVVGPPPLAQAVRLVNGTPAQEERPPLSGPPRILYSARLQARKRPVDFVDAAPAVLAAHPDAEFVVAGPDEGELAAVRARVAALGLTDRFTVPGALSTPEVLTELRRAHVYVLPSVDEPFPMSVLEALSVGVPTVVTHSNGLARDIAASGAGRAVDPGPQGVAEAVLALLDPAENAAASKAARELAAGSFSMDAVLDTLLGVYEDAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J524</accession>
    <name>A0A0F4J524_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000697">
        <property type="protein sequence ID" value="KJY28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949719.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000697.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28858">
        <property type="protein sequence ID" value="KJY28858"/>
        <property type="gene ID" value="VR44_24335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.849"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="30438" checksum="5AF0D8D07630D1EC" modified="2015-06-24" version="1">MAKSKDEGAAQSPEEFAREELRRHREAAGLTQEALGERIFVSGSYVGQMECGTRRLRPELAEAIDRELGTGDYFLRLARAFKSKHVEYFAAAAELEAMAAAIYEYASTLVPGLLQTEDYARALIRGGNPTALAEYVDGLVESRLDRARLLDDPTAPEMWVVLHEAVLRTAVGGYGVMAAQLRHIASYVRAHRITMQVVPFSAGAQGALGSLVTIMQFADAPDVVYTEGPRVGQLLDYPALVRTHWKLYDLARAAALSPEVSLTLIESVAEEYATCTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5H3</accession>
    <name>A0A0F4J5H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_22485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000630">
        <property type="protein sequence ID" value="KJY29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29607">
        <property type="protein sequence ID" value="KJY29607"/>
        <property type="gene ID" value="VR44_22485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.386"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17547" checksum="3483BEF2B7735FB2" modified="2015-06-24" version="1" fragment="single">ALHLSFPLAPPRMLEAAHLVDTGQVYGPTVYRAAPDADTMANQFAAMPSLHFGWALMLALGMIAATRSRWRALWLLHPLATLLVVVGTANHYWVDAIVATLLLGAALLLIPRPAAAAPGPLPRLPRPRRTAPSPGTAPAGPGALEAPAGPVPVPEPLRPLPVTAGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5J8</accession>
    <name>A0A0F4J5J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29114">
        <property type="protein sequence ID" value="KJY29114"/>
        <property type="gene ID" value="VR44_23725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.693"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="36020" checksum="B543CBFB1C966200" modified="2015-06-24" version="1">MARPTSRVLTLLELLQSGGIRTMAELADRLGVDARTVRRYVGHLVDLDIPVEAIRGRYGGYRLAPGYRLPPLMLNDDEALAVLLGLAAGRRTGLPATTGTAGETAAAKIRRALPERLARRLDAVMESLAFTAEPGEAATPETGVLLAIADAVRHSRPTLIRYTARDGRRSERTLHPYGIVAHEGRWYITGSDPEIGQDRTFRLDRIADARPLPGSFEPPAGLDPAQRVLSGLAGAAYRHEVTLRIHGTVEQIRTRLPAGIASVKEIVPAEAADPHTERWFHVELRAERLDWLPPVLASLDRPFVIERPDELRDLVLALADRLAASARQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J652</accession>
    <name>A0A0F4J652_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">VR44_23395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949544.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5182"/>
    <dbReference type="EnsemblBacteria" id="KJY29243">
        <property type="protein sequence ID" value="KJY29243"/>
        <property type="gene ID" value="VR44_23395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.621"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="38095" checksum="117DAFB3291444FD" modified="2015-06-24" version="1">MRQILFAGVIGMFLTVIGTPLLIKLLARKGYGQFIRDDGPRGHAGKKGTPTMGGISFILATLIAYALTKVITGESPSFSGLLVLFLMAGMGLVGYLDDYIKIVKRRSLGLRAKAKMAGQLIVGIAFAVLALQFKDSRGLSPASEKLSFVTDFGWSIGPVLFVVWALFMILAMSNGVNLTDGLDGLATGAAVMVFGAYTFIGVWQHQESCANAVTLTNPNACFEVRDPLDLAVVASALMGACFGFLWWNTSPAKIFMGDTGSLALGGALAGLAICSRTEFLMALLGGLFVLITMSVVIQVGSFKLTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGMCVIVGLGLFYAGWAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J679</accession>
    <name>A0A0F4J679_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949507.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000652.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7556"/>
    <dbReference type="EnsemblBacteria" id="KJY29344">
        <property type="protein sequence ID" value="KJY29344"/>
        <property type="gene ID" value="VR44_23200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.580"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="7253" checksum="D084380A3543E18F" modified="2015-06-24" version="1">MRLTIFWERMAEHFGAAYADSFARDHVMSELGGRTVHQALEAGWETKDVWRAVCAAMDVPASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6F9</accession>
    <name>A0A0F4J6F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29932">
        <property type="protein sequence ID" value="KJY29932"/>
        <property type="gene ID" value="VR44_21575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.193"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="7146" checksum="0D64A63373730607" modified="2015-06-24" version="1">MPTALPPPALLMTVPEVMATLKLGRHSVYNLIRSKRLPSITVGRARRIPADAVHRFINTELESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6V0</accession>
    <name>A0A0F4J6V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000711">
        <property type="protein sequence ID" value="KJY28656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7573"/>
    <dbReference type="EnsemblBacteria" id="KJY28656">
        <property type="protein sequence ID" value="KJY28656"/>
        <property type="gene ID" value="VR44_24890"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="28131" checksum="CDACF4596C306B87" modified="2015-06-24" version="1" fragment="single">MDRAARPRTLRFGANYTPARGWFHHWLDFDLDEVRADLDSVAALGLDHVRVFPLWPLFQPNRTLIRPRAVEQLVALADAAAERGLDVHVDGLQGHLSSFDFLPAWTGTWHRRGLFTDPDVVAGQEEYLRTLAAALAGRPNFLGMTVGNEVNQFSDAPHPDPDRITAAQAGRWLERMLAACEEGAPGRFHLHAEYDAVWYRDGHPFTPAQAARLGAATAVHSWVFNGTAQRHGRTGTATEQHAAYLIELSKAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J789</accession>
    <name>A0A0F4J789_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28806">
        <property type="protein sequence ID" value="KJY28806"/>
        <property type="gene ID" value="VR44_24525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.900"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="14131" checksum="13EBF3241433F3E8" modified="2015-06-24" version="1">MRLEAAPLPVPLEGVFVYRTDRPYEVAVEFRGAGVRIARWVFSRELLIDGQSCATGEGDIQVWPRWSGTEPRVLLALSNGERGCVVSARAKDLRELCRRMTELVPRGQEDRHYDLDAELSALLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Q1</accession>
    <name>A0A0F4J7Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_21950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000613">
        <property type="protein sequence ID" value="KJY29824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4655"/>
    <dbReference type="EnsemblBacteria" id="KJY29824">
        <property type="protein sequence ID" value="KJY29824"/>
        <property type="gene ID" value="VR44_21950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.270"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="31500" checksum="7831D276F045A236" modified="2015-06-24" version="1">MHEAPPQGTPAHGAPAGLQEPAAPAPRPQSRGADTRALTQVLFGQLKGLEPGTSEHNRVRGALIEANLPLVRYAAARFRSRNEPMEDVVQVGTIGLINAIDRFDPERGVQFPTFAMPTVVGEIKRYFRDNVRTVHVPRRLHELWVQVNAATEDLTTLHGRTPTTPEIAERLRISEDEVLSCIEAGRSYHATSLEAAQEGDGMPGLLDRLGYEDPELAGVEHRDLVRHLLVQLPEREQRILLLRYYNNLTQSQISAELGVSQMHVSRLLARSFARLRSANRIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J820</accession>
    <name>A0A0F4J820_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29919">
        <property type="protein sequence ID" value="KJY29919"/>
        <property type="gene ID" value="VR44_21670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14600" checksum="CDBDED7BA0C25094" modified="2015-06-24" version="1" fragment="single">VIAAAAPFSGGGAAGDLKWSVVSWQSAKGLAISEYSLQNRTVLAGLLGFAVGAACLGWLQIIVVSPLRELARRAEALADGDRRTVLYPRHHDEVGAVTRSLEIIRQQLQQGGRRRGRQRTTTDTGGAATPSARPAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J842</accession>
    <name>A0A0F4J842_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949193.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29949">
        <property type="protein sequence ID" value="KJY29949"/>
        <property type="gene ID" value="VR44_21500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.178"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="10032" checksum="E9714D66613BA966" modified="2015-06-24" version="1">MKPIVARHTPVTPLPVDLEPTDAELEAIEWELPLILAERDLLDVEISVLDRMPSELDERRIRRARRKMLAVRRALTNQALAVNMPGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8J4</accession>
    <name>A0A0F4J8J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949133.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000589.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5042"/>
    <dbReference type="EnsemblBacteria" id="KJY30109">
        <property type="protein sequence ID" value="KJY30109"/>
        <property type="gene ID" value="VR44_21195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8962"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="36198" checksum="2E1AE20B7C7DA890" modified="2015-06-24" version="1">MTARLADIAAQAGVSEATVSRVLNGKPGVAAGTRESVLAALDVLGYERPVRLRQRSAGLVGLITPELDNPIFPALAQVIGQALTRQGYTPVLATQTPGGSTEDELTEMLVDRGVSGIIFVSGLHADTTADMGRYEQLRGQGVPYVLINGFSDKVRAPFVSPDDRAAMQLAVTHLTALGHSRIGLAVGPKRFVPVLRKIEGFRLAMKERLGLQEAEAEELIQHSLYTLEGGQAAAAALIGRGCTAVVCASDMMALGAIRAARQQGLRVPQDVSVVGFDDSPLIAFTDPPLTTIRQPVQAMGQAAVRTLLEEIGGTPAPHSEFVFLPELVVRGSTASGPGQRRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8J5</accession>
    <name>A0A0F4J8J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30717">
        <property type="protein sequence ID" value="KJY30717"/>
        <property type="gene ID" value="VR44_19675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8550"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="10075" checksum="098D287178F1DEB9" modified="2015-06-24" version="1">MVFGRFHPRRFRRNHFTPVPEVDSLAELNELVDQWDLHDRRRRLGSRQWTIDEYFEVERPLLTPLPEEPFETGRLFTPRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9N4</accession>
    <name>A0A0F4J9N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000519">
        <property type="protein sequence ID" value="KJY31077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3401"/>
    <dbReference type="EnsemblBacteria" id="KJY31077">
        <property type="protein sequence ID" value="KJY31077"/>
        <property type="gene ID" value="VR44_18950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8393"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="31209" checksum="D0E390CA54529EEE" modified="2015-06-24" version="1">MMTAARHADTGLAGPGELDRYPYAETSGADRAGPPHWDGADVELSRVGRRAAGSRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVADWNLLDPDIIEWRAFGPQRDDQRRELNELRWTIEPLAARLAAGHGRPDVQQRLSDMVEIMGHALGQGDAITFARADNEFHALLIQVAGNRMLEHLSGIVSAALQVSGSPITSCDRPSETCVAHHARMVEALATGDGAGAESAMRQLLTVHPEVERVVPAPREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC06</accession>
    <name>A0A0F4JC06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948385.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000456.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31897">
        <property type="protein sequence ID" value="KJY31897"/>
        <property type="gene ID" value="VR44_17160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7964"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="27"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="645" mass="69085" checksum="0393A4D97CBFF2AF" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC70</accession>
    <name>A0A0F4JC70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948433.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31805">
        <property type="protein sequence ID" value="KJY31805"/>
        <property type="gene ID" value="VR44_17430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8023"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="676" mass="70397" checksum="FEE6521E5BF4FEAD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCZ2</accession>
    <name>A0A0F4JCZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000428">
        <property type="protein sequence ID" value="KJY32222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948232.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000428.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32222">
        <property type="protein sequence ID" value="KJY32222"/>
        <property type="gene ID" value="VR44_16355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7728"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9141" checksum="2FFFB5B8CBD53D45" modified="2015-06-24" version="1">MLNARESIEAEIVRLVQGAGGDAPALSLTTDLVGLGLTSLMFAELLIGMEMELGVDPFQGETSIVEMRTVGDLVTAYDDALAAASARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD58</accession>
    <name>A0A0F4JD58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">VR44_19300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000528">
        <property type="protein sequence ID" value="KJY30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948791.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000528.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5425"/>
    <dbReference type="EnsemblBacteria" id="KJY30911">
        <property type="protein sequence ID" value="KJY30911"/>
        <property type="gene ID" value="VR44_19300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8466"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="21787" checksum="6DCE6BDC1A98DDC9" modified="2015-06-24" version="1">MAASRLVVLVSGSGTNLQALLDAIDAHPGGAEGFGAEVVAVGADRENIAGLERAEKAGIPTFVCPVKAYGSREEWDAALTEATDAYAPDLVVSAGFMKIVGKNFIDRFGGRFINTHPALLPAFPGAHGVRDALAYGAKVTGCTVHFVDSGVDTGPIIAQGVVEVLDGEDEAALHERIKEVERQLLVDVVGRLARHGYRIEGRKVTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDI2</accession>
    <name>A0A0F4JDI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000465">
        <property type="protein sequence ID" value="KJY31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948436.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31808">
        <property type="protein sequence ID" value="KJY31808"/>
        <property type="gene ID" value="VR44_17450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8027"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23615" checksum="C5E34E1802CF109F" modified="2015-06-24" version="1">MIGEPEIEGGWATEAPARFADAAGPEGRDGSLRAAPWRWALGGALVASAVFAGVLVVQERYGEAGPPIRYRHSEQLCSETPLKSVGAALGGLGGGTPGHGEGPALDWSSCAASGNREDQAFMSDARVMVELHKKTDPGPEFGLVPGMEAYGVPVTSEKVSGLGERALFIGVRHSPRLQVLDGGTVVTLTVSWWTKGAADPGDKVDEDAVKAAMVEDARALLTRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEB2</accession>
    <name>A0A0F4JEB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000440">
        <property type="protein sequence ID" value="KJY32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948297.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000440.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32088">
        <property type="protein sequence ID" value="KJY32088"/>
        <property type="gene ID" value="VR44_16685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7770"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="43818" checksum="1C794782D5A91851" modified="2015-06-24" version="1">MSETLPGALSFPQDRTCPYHPPAAYQPLRDARPLTRVTLFDGRSVWMVTGHAEARALLADGRLSTDRTHEGFPLPSARFKGITRQRTALLGEDDPVHNTQRRMLIPSFSVKRAAALRPRIQETVDGLIDAMVARGPRAELVGAFALPVPSMVICALLGVPYEDHEFFEAQSRRLLRGPGPADVEDARAQLQGYLRALILRKRAEPGEGLLDELIATRLESGETDVEELVSLAAILLIAGHETTANMISLGTFTLLRHPEQLAELRADPSLLSGAVEELMRFLSIADAMLRLATEEIEVGGVTIRPGDGVVFSTSVINRDEAVFQEPDVLDWHRRSNRHLAFGFGIHQCLGQNLARAEMEIALGTLFDRLPGLRLAADPDTIPFKPGDTVQGMIELPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEF7</accession>
    <name>A0A0F4JEF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone GroES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000405">
        <property type="protein sequence ID" value="KJY32575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948115.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32575">
        <property type="protein sequence ID" value="KJY32575"/>
        <property type="gene ID" value="VR44_15735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7551"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="36974" checksum="83D44DFF91CC7A84" modified="2015-06-24" version="1">MRGVVFDGKQAQVVGDLEIRDPGPGEVLVAIGAAGLCHSDLSVIDGTIPFPSPVVLGHEGAGVVEAVGAGVTHVAPGDHVSLSTLANCGACADCDRGRPTMCRRAIGMPDRPFSRGGQPLFQFASNSAFAERTLVKAVQAVKIAEDIPMTSAALIGCGVLTGVGAVLNRAKVGLGETVVVIGTGGIGLNVIQGARIAGASVIVAVDANPAKEGVARQFGATHFVDASAAGDLAGTSAAVREILPTGADHAFECVGSVKLIRQAIDLLDRHGQAVLLGVPGFKEEASFLVSSMYLDKTIMGCRYGSSRPQRDIALYAELYRRGELLLDELVTEVYPVEDFAKAADDAHHGRVARGVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF67</accession>
    <name>A0A0F4JF67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000379">
        <property type="protein sequence ID" value="KJY32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2594"/>
    <dbReference type="EnsemblBacteria" id="KJY32972">
        <property type="protein sequence ID" value="KJY32972"/>
        <property type="gene ID" value="VR44_14820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7361"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17166" checksum="354BDD427675C286" modified="2015-06-24" version="1" fragment="single">RQQARELDADTVRQAFASVTSPGRMEVVRRSPTVILDAAHNPAGAQVTAEAVTEAFGFSRLIGVVAASEGKDVKGVFEAFEPIFAEVVVTENTSHRAMGADELAAIAVEVFGPDRVQVEPRLDDALEAAVTLAEEEAEYGGAGVLVTGSVITVGEARLLFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFK4</accession>
    <name>A0A0F4JFK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947886.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33122">
        <property type="protein sequence ID" value="KJY33122"/>
        <property type="gene ID" value="VR44_14450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="16867" checksum="9774612C4558FBE5" modified="2015-06-24" version="1">MPHPRVRPLDLADEATAVAVHRIGRAAYTVEAELIGFDGIPALGESLDEMRGRALEWLGAVGPDGAVAGFLAWEEPAAGGPVGLDRLCVDPAWFRRGVASLLLRHALEELFPGRPVEVTTGADNTPAVALYERLGFVRGGDFSPVPGLRMASFTLTPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG90</accession>
    <name>A0A0F4JG90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cysM</name>
        <name evidence="4" type="ORF">VR44_17040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000450">
        <property type="protein sequence ID" value="KJY31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948362.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000450.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7014"/>
    <dbReference type="EnsemblBacteria" id="KJY31966">
        <property type="protein sequence ID" value="KJY31966"/>
        <property type="gene ID" value="VR44_17040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7938"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="9"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="26538" checksum="EDB8369C3EBFAA52" modified="2015-06-24" version="1" fragment="single">MRYDSPLAAVGNTPLVRLPRLSPSADVRIWAKLEDRNPTGSIKDRPALHMIEQAEKDGRLFPGCTILEPTSGNTGISLAMAAKLKGYRIVCVMPENTSQERRDLLAMWGAEIISSPAAGGSNTAVRVAKELAAEHPDWVMLYQYGNPDNAGAHYSTTGPEILADLPSITHFVAGLGTTGTLMGVGRYLREHVPGVKIVAAEPRYDDLVYGLRNLDEGFVPELYDASVLTTRYSVGSADAVTRTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGE5</accession>
    <name>A0A0F4JGE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32026">
        <property type="protein sequence ID" value="KJY32026"/>
        <property type="gene ID" value="VR44_16865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7808"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20629" checksum="3F358A7270B9A6EC" modified="2015-06-24" version="1">MTTTLDPAAQSAVVLRPARLSLTPKTALAGRLDGAWWPHSRDLEAELPALAAALDETWGRITRVLVNPSRWPVVPRTVTVAVAGHLLHVGWFTEQDPDKLILLSYTVGRWDLLVIPPETEPAAAARLLAAAAIPGSVLAADALMANETVIGRSIREALRREATWEDEGGACMSPYGNPMGRTALPLPGHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGR0</accession>
    <name>A0A0F4JGR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ORF">VR44_14790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007264060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2602"/>
    <dbReference type="EnsemblBacteria" id="KJY32984">
        <property type="protein sequence ID" value="KJY32984"/>
        <property type="gene ID" value="VR44_14790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7354"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="428" mass="46919" checksum="626A4278A06EB4EC" modified="2015-06-24" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLESYVVGQEPAKKALSVAVYNHYKRVQAGENGGAQGRDDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKIIESRAGAKGIGFGATIRSKREIEASDQFQEVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLQILVEPRNALVKQYQRLFELDGVELDFEREALEAIADQAILRQTGARGLRAIMEEVLMSVMYEVPSRKDVARVVITADVVRSNVNPTLVPRIVPKDQGPHEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHR9</accession>
    <name>A0A0F4JHR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947688.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2645"/>
    <dbReference type="EnsemblBacteria" id="KJY33750">
        <property type="protein sequence ID" value="KJY33750"/>
        <property type="gene ID" value="VR44_13370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6910"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="32894" checksum="D22FD12A7B66B4FD" modified="2015-06-24" version="1">MTGRTRRTRRTRRTGGRAGRRALLHWIGVHALAVAAALFFVLPFVFLLLTSLMADQQALTRDLWPRTWEWGNYAAVWHTPGFLTWWRNTLLYAGLGTLLTVVSSVPVAYALAKFRFRGRRLALLLVIAMMMLPPQVVVIPMYLFWARELDLSGTLWPLIVPMAFGDAFSVFLLRQFLLTIPDEYLDAARVDGCGELRTLLRVVLPMARPGIAAVALFQFFAAWNDYFGPQIYASDNPAAWTLSYGLESFKGAHHTNWNLTMAATVLVMAPVILLFFLAQKAFVEGVTLTGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIE3</accession>
    <name>A0A0F4JIE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947532.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34117">
        <property type="protein sequence ID" value="KJY34117"/>
        <property type="gene ID" value="VR44_12520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6565"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="45091" checksum="6918433B22D371E8" modified="2015-06-24" version="1">MPDPGPSPLQSVLPSRPVLPFGTAAPPVEPPGPAGAPPVEPSGPAHSAAALRRILRGPSGLGTVSLHWARPEEPPAAAQPVTPAAMRPIPGLYHHPVPEPDPVRVEELSRRIKSWAVDEVQAFPPEWEDQFDGFSVSRYMVACHPDAPTLDHLMLAARLMVAENVVDDAYCEDGATTPDVGGRLLLAHTALDPVHTAKEYQPAWEESLHSDAARRSYRSAMEYFTAAATPAQADRFRHDMARLHLGYLAEAAWDETEYVPEVWEYLAMRQFNNFRPCPTITDTVGGYELPADLQALPAMQRVIALAGNATTISNDLYSYMKELRSPGRHLNLPVVIAEKEGLSDKEAYLKAVEVHNDLMHEFEAAAAELAAAWPDPRVARFLKGVAVWVDGNHYWHASNTYRYTLPDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIG5</accession>
    <name>A0A0F4JIG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947746.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33599">
        <property type="protein sequence ID" value="KJY33599"/>
        <property type="gene ID" value="VR44_13650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7006"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="34658" checksum="43A96F1F205EF9C8" modified="2015-06-24" version="1">MSYAAVEGAWAVTGTAVQWKEHSTYAPWVQLLLAALALLAGGACLAGTRDLGPFGRVAVATALIVGLAVFVVGMNGLPIHFVTMATLSGVESATGLAQVLLNTAGAALLFLVWISYRRRLRGDCPRCGRRHTGAADGPLVHPAASRAPRRTRVVVYLLAGGLLPWAGAKTLWTLGGNALGVAGDDWQRMAVAGASGPSKAIASAGIDVTVLAAMVGVFLLLGLLYGWGQVFPRWTPFLSGRRVPRLLPLIPAWLTGIPLAMYGAVLIVMAPLMAAGVLPPVQPSPPFTTSSGITWVVEFGGLAFGGLGFALVAAARSYTARTRPVCAGALATAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKL5</accession>
    <name>A0A0F4JKL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000298">
        <property type="protein sequence ID" value="KJY34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947460.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34318">
        <property type="protein sequence ID" value="KJY34318"/>
        <property type="gene ID" value="VR44_12145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6517"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="510" mass="53883" checksum="5363B1E65D5F1415" modified="2015-06-24" version="1">MNTQVTGVIVVGAGGAGLTLATELALAGTPAVVLDRLPGRNLQSRAGAIQPRTAELLALRGLLDEALGRSIDYRLVGGHFAGLPVPLDYAAWDTRYPHPVLLPQDQLEAVLEERLAELGGRVLREHALTGLRQDADGVTITMTTPDGDRSLRGRFLVACDGAHSSVRKTVGAAFPGQAATVRMATADLVLTGQVDDSSAGHISSRIHTSPEGHFAMITPLANGLHKLIFSGPRTASAERDAPVTAEEVREVLRATHGGALDVSEIRYASRFSDASRQLEHYRHGRVFFAGDSAHIHSPAGGQGLNLGVQDAFNLGWKLAAILRGEAAEELLDSYQTERHPVAARVLALTRAQGVVMGPQRDGGLGELRDVLTDLLRLPEANRYMAGVMSGLDLRLPSPDAADHPLLGLRMPDLDLLTGDGGQVRFSDLTRGGRGVLIDLAEAPLAAADPWNDRLVRVRARVEKGAVDAEAVLVRPDGYVCWAGGAGLTATLTRWFGPAGAAATGTAGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM18</accession>
    <name>A0A0F4JM18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000261">
        <property type="protein sequence ID" value="KJY34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947297.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000261.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34813">
        <property type="protein sequence ID" value="KJY34813"/>
        <property type="gene ID" value="VR44_11270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6264"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18125" checksum="E80FE5722560B617" modified="2015-06-24" version="1">MASLVEIAGEFDLPPHEIASPLVQAAQETALTAAFLDNELLSRGKEEARGEYDCGLIPVLLAESGPRTLQEAVDDTVALRDRVMDLHLRLAAAAVRADAGPRTRDYVDLLGRASAGITTFSRDTLRYTTPHQRKPPMTSHPTPPRRGPCRSRLPPQIGRWTQRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMB5</accession>
    <name>A0A0F4JMB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947257.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34949">
        <property type="protein sequence ID" value="KJY34949"/>
        <property type="gene ID" value="VR44_11050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="16"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="689" mass="73011" checksum="142A38C029C539C7" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNE2</accession>
    <name>A0A0F4JNE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946947.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35715">
        <property type="protein sequence ID" value="KJY35715"/>
        <property type="gene ID" value="VR44_09405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5209"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11473" checksum="530057B87F0A681D" modified="2015-06-24" version="1">MIPVNQLSDPAVRAFVAALNAGDQQAFGAALTPGATMSDDGSDRDLNDWAEREIFSSNGHMDVEAESDGGRSLVADYRNDTWGSMRTAWRFTVSDGRVSRFETGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNJ8</accession>
    <name>A0A0F4JNJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35922">
        <property type="protein sequence ID" value="KJY35922"/>
        <property type="gene ID" value="VR44_08890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4947"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="502" mass="52404" checksum="68D7E58B70E574A3" modified="2015-06-24" version="1">MPGRSPGGAGGSSVADVLVVGAGVLGRSVAYALASAEPSVRVVLSGRRGPGASRAAGAMLGVLGEVTAAGLRTRHGTLRTGMAVEAARLWPAWRQRVRAVAEEVAPPGPDGYGTGTYVLLNAVSGPLDEEATEAMRGAGARYGLPVEDVDVPDVPSYRPLDNDRALRALFLPQEGFLDARRWLDTLDTALRALPNVLRTGSGRLRAAGEEYELTTPDGVFRAEKVVVAAGAWTSPLLTGLDPELPVLPVVSAEGTAVSVRAPQPAPPVVLRTPNRAYACGLHAVPQADGGWYLGASAAPALEPGEAPTAGALRFLLDAGLGQLHHGLATARVDRVHHGNRPVGLDGHPLLGATGRPGLWVATGTHRDGLHASPLIAQELTAQILHGTPSPWLAPWRPDRAPIADRSITEAVEEAVSHHAALAAESRMRPPLTGDWPGLLADAYRQLMEQAYGRMPDGYVPPPELAPLAYEQGPALAELARSHLDARAGWGTPRAGHMAVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNP4</accession>
    <name>A0A0F4JNP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35388">
        <property type="protein sequence ID" value="KJY35388"/>
        <property type="gene ID" value="VR44_10255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5919"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16423" checksum="0DC721E9D1CC675B" modified="2015-06-24" version="1">MGSATLYRNFPTREALIEAVYRNEVAHLCEAAPALLAQKPPAEALRAWTRLFLDYVTAKYGMIDALRAIAATGNNPYGHSREMIQAAITSLMDACMAAGAIRTDIQPTDIGAALEGIALTSAGAEHRQQAERLLDLTLDGLTVLTLDGLTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNT2</accession>
    <name>A0A0F4JNT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947088.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3208"/>
    <dbReference type="EnsemblBacteria" id="KJY35484">
        <property type="protein sequence ID" value="KJY35484"/>
        <property type="gene ID" value="VR44_10155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5631"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24058" checksum="17F9B69E89C406E3" modified="2015-06-24" version="1">MAIRVLLVDDQPLLRTGFRMILEAEQDLVVVGEAGDGLQALEQVRALQPDVVLMDIRMPRMDGVEATRQITGPERNGPAKVLVLTTFDLDEYVVEALRAGASGFLLKDAPANELVQAIRVVAAGEAMLAPSITRRLLDKYAGHLPSGEESVPDVLGTLTEREVEVLKLVARGLSNAEIAADLFVSETTVKTHVGHVLTKLGLRDRVQAAVYAYESGLVRPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPP2</accession>
    <name>A0A0F4JPP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946950.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35718">
        <property type="protein sequence ID" value="KJY35718"/>
        <property type="gene ID" value="VR44_09420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5212"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470763" evidence="1">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="45321" checksum="C9600F69BDD66833" modified="2015-06-24" version="1">MQRRIFGAAATATVFGLLVPLSGCGSSAGDAGDSGTLRLVAAEYGDSPANSSKAFWDKVTKDFTAANPGIKVQVQLLPWADIDREVSRMVKAGNAPDMALMGSYSDFAAQGKLYSAEELLSISAEANFLQPLAEAGSVGNTLYGLPFVASSRLLFYNDTLFRQAGITNAPKTWSDLTADAKALKEKGVKYPVALPLGPEEAHAEAMIWELSNGGGYADNSGNYSLASDQNISTFRWLKEKLVTPGLTGPTPPSQLNRADAFAAFLRGEVGMVNGYPSLLHEARAKGMTVNAVPMPVSDTLGAGETPPTVGVADWMMAFKQNGKGAEIGKFLDFVYQDKNLSDFAGRYHLLPSTVSASRTPSGGGLDRNDEQFLTALRGAQLYPVNDPSWVTVSDTIKRNIGHAVDANGDAKAVLEGIAAKAAEAGRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ83</accession>
    <name>A0A0F4JQ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946655.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000154.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36522">
        <property type="protein sequence ID" value="KJY36522"/>
        <property type="gene ID" value="VR44_07825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4271"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="25429" checksum="2C4735077DCCA9D6" modified="2015-06-24" version="1">MNRFTGRTVLVTGAGSGIGRAIALAFAAEGARVVAAGRTAAPLEETVALIEAAGGTAAAVPADVTDSGRLAGLVRETAERFGGLDIAVNNAGILRGTVPAADIAEEDWDAVLRTNVTGVWLAMKHEIAHMRENGGGVIVNVSSNLGAHTRIPNAAAYVTSKAAVAALTRAAALDHIREGVRINAVSPGATAAPMSLRPGETEADRVERIKGENPLGRLAEAEEVAAAVLYLASPEAGAVVGTDLVVDSGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQU3</accession>
    <name>A0A0F4JQU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="8" type="ORF">VR44_08480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946778.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene932"/>
    <dbReference type="EnsemblBacteria" id="KJY36118">
        <property type="protein sequence ID" value="KJY36118"/>
        <property type="gene ID" value="VR44_08480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4759"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="160"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="48795" checksum="895118C6643D2368" modified="2015-06-24" version="1">MSNTPNAADHAASRETTEGTVYTVTGGDWDEIVRSAAKADDERIVVNMGPQHPSTHGVLRLILEIDGETVTEARCGIGYLHTGIEKNLEFRNWTQGTTFVTRMDYLTPFFNETAYCLGVEKLLGITDQIPDRATVIRVLLMELNRLSSHLVCIATGGMELGATTIMIYGFRDRELILDVFELITGLRMNHAFVRPGGLAQDLPPGAVDQLREFVKTMKKNLPEYDKLATGNPIFKARMQDVGYLDLAGCMALGATGPILRSAGLPHDLRKTDPYCGYDSYEFDVPTTESCDSYGRFLIRLEEMRQSLRIVEQCLDRLEPGPVMVADKKIAWPAQLAMGPDGLGNSLDHIKNIMGTSMEALIHHFKLVTEGFRVPAGQAYAAVESPKGELGVHVVSDGGTRPYRVHFRDPSFTNLQAMAAMCEGGQVADVIVAVASIDPVMGGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR24</accession>
    <name>A0A0F4JR24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_07220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946540.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4602"/>
    <dbReference type="EnsemblBacteria" id="KJY36812">
        <property type="protein sequence ID" value="KJY36812"/>
        <property type="gene ID" value="VR44_07220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="102"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="608" mass="65128" checksum="E62B0E46EF8B3DEA" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR58</accession>
    <name>A0A0F4JR58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946736.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36238">
        <property type="protein sequence ID" value="KJY36238"/>
        <property type="gene ID" value="VR44_08275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4554"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16466" checksum="44E5D48FEB411819" modified="2015-06-24" version="1">MNAATFAAVFAALYVAHSVGDHWVQTSRQSADKGKAGWTGRLADARHVATLTATKLALLLPVALLLGLELSVLGLAVGLGVDAVTHWWADRRSTLAWLAKVAGQTEFYQLGTGAHPLHPVTAEGTPATHLGTGAYALDQSFHHLWLLVAALLITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRI7</accession>
    <name>A0A0F4JRI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000164">
        <property type="protein sequence ID" value="KJY36388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36388">
        <property type="protein sequence ID" value="KJY36388"/>
        <property type="gene ID" value="VR44_08130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="17962" checksum="5B81188D8AC5CC73" modified="2015-06-24" version="1" fragment="single">MPDEVDAVRDTGNVLEVKGLSRSYGAVRAVDDVSFVLPAGGSLGIVGESGSGKTTTARIVVGLERADAGEVLVAGRSRTAPGGGRGRAGRLARAREVQMVFQDPYLSLDPRTSVEAALREPLALHFPGRDHTKRVRELLDQVGLGTRDADALPRQLSGGQRQRVAIARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS76</accession>
    <name>A0A0F4JS76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_09140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000198">
        <property type="protein sequence ID" value="KJY35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813651.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5116"/>
    <dbReference type="EnsemblBacteria" id="KJY35806">
        <property type="protein sequence ID" value="KJY35806"/>
        <property type="gene ID" value="VR44_09140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5092"/>
    <dbReference type="eggNOG" id="ENOG5032TTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14834" checksum="41A52C223E6820FD" modified="2015-06-24" version="1">MKIQGKMFLWLSVFILIMTVVYGVWSKEPVGTTALALAFGLSAMIGYYLAFTARRVDEMAQDNLEADVADEAGELGFFSPHSWQPLSLGIGGALAFMGVIFGWWLMYFSAPIILIGLWGWVYEYYRGENQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSG0</accession>
    <name>A0A0F4JSG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946427.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37105">
        <property type="protein sequence ID" value="KJY37105"/>
        <property type="gene ID" value="VR44_06575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3231"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8339" checksum="F5AAF31126AD8624" modified="2015-06-24" version="1">MPAWPRITCPACRRSVAVSPDTRHLARHDPPGPQNRRHGLPPISCIASGRLIPAGSDLLLPLWVDTAPAAAGEKLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTB4</accession>
    <name>A0A0F4JTB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946206.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37602">
        <property type="protein sequence ID" value="KJY37602"/>
        <property type="gene ID" value="VR44_05405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="27705" checksum="803276C455490D12" modified="2015-06-24" version="1">MILTDFDYARAASLEEALTLLAGTDGARVLAGGQSLLPGLRTGAEKARLLIDVRHLAQLRGVGQDGGELRIGALTTLAELAADPLVRAGAPELAAAARANGDPQVRNLGTVGGNLAATERPTDLPVAAIAAGARAELAGPGGTRTAPAEELAASGVPAGEVLTALLVPAAGAAAAFEKTADRATRYPVCAAAVRITPDGPRIAVTGATPRALRLRGVEDRLRGGPYTTTAVLAAFRAEPRELFVPGRGTSAEYLGHLAGVLTARALARAAAHSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUE4</accession>
    <name>A0A0F4JUE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_04635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37962">
        <property type="protein sequence ID" value="KJY37962"/>
        <property type="gene ID" value="VR44_04635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1008"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471046" evidence="6">
        <location>
            <begin position="38"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="11"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="497" mass="50790" checksum="F1719B872B3EF660" modified="2015-06-24" version="1">METRNPRRWWILIVLCLSSLVLVVDSMALTVAVPSMTADLGASAQDTQWILDSYVLVFAGLLLTSGSLGDRFGRRRIMLIGLLLFGAASLAASFAADPAQVIAVRVVMGVGGALIMPSTLSILITVFDDEERPKAMAAWGSVAMLGLVGSPVLGGVLIDRFSWQSIFLINVPVVVLAVVAALTLMPESKGPWKKPDPLGAVLSATGMTALVWWIIEIPQHGAFGGRSALTLAVAVVALAGFVLWERSTDSPMVPLFLFGNRNFSGGSLSLTLVQIGNGGLLLVLTQYLQFVLGYSPLKAGLAFVPLAVAALIGNGAGAGLAARIGNRPLILAGMLVMASSFALLTTVTADTGFTVPAVALGLLGLGAGLAMPAAVGALMGTIPEEHAGVGSALNDTIQQAGTALGIAILGSLLTSGYTAKMPADAPAGARHSLAGALAAAPGDSGLLRTAREAFTSAMATTFTLSAAGLLAAALLATVVMRDRKPAPTPQPEPEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUH1</accession>
    <name>A0A0F4JUH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946244.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37413">
        <property type="protein sequence ID" value="KJY37413"/>
        <property type="gene ID" value="VR44_05605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1934"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14746" checksum="B41E70BA852D5C09" modified="2015-06-24" version="1">MSSTMIFVNLPVSDLEATKAFWGKLGYSFNAQFTDENCAAMPISDSIVAMFLTEARYKDFTHKAIADARTTSEVLLCLSAESRAAVDELVDGALAAGATEPRPAQDHGVMYGRAFDDLDGHTWEIMWMDPAMVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVH7</accession>
    <name>A0A0F4JVH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37854">
        <property type="protein sequence ID" value="KJY37854"/>
        <property type="gene ID" value="VR44_04830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1047"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14861" checksum="866777C1C44E86C2" modified="2015-06-24" version="1">MSTDMSARTAHAVALLKETSPETLDAFLALAGRFEATTLDPHSREAVILTVAAHNQCHLCIDMHEAKVSALGPAPDPRRIEAVRRFTRQVLASSGAVSDGELAEFQAHGYTRRNALEVVLGIGAYTLSTFANRMTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVP8</accession>
    <name>A0A0F4JVP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_03980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945945.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38240">
        <property type="protein sequence ID" value="KJY38240"/>
        <property type="gene ID" value="VR44_03980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8701"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26415" checksum="D4B4E3472AEEBC7A" modified="2015-06-24" version="1">MDTEAELTQRGHSSPEQGEEWPRCVFSGLRASFRSPWRRAGALGVVCTVFLLLVSNFVVQPFLIPSRSMEPTLKVGDRILVNKLAYRFGATPQRGDVVVFDGTGSFVREPARGNPVGDALHGAASALGLAEPSDTDFVKRVVGVGGDDVVCCDTGGRIRVNGVPVAEPYLYPGDTPSEVPFRIVVPLGTLWVMGDHRSQSRDSRDHLGEPGGGMVPVEKVIGRADWIGWPASRWGSLPAGAAAGGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW42</accession>
    <name>A0A0F4JW42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945840.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38582">
        <property type="protein sequence ID" value="KJY38582"/>
        <property type="gene ID" value="VR44_03360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7889"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="104"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28212" checksum="0BB854BF8036C45D" modified="2015-06-24" version="1">MSSASDPLAALGALPGVAESVESVRKAVDRVYGHRVMRRRSGEITSEAALRGARGSAALSGADWALEEVRRRTDFSADAEALTVGAALRLTAEAGQLLSIWRQSPMRVLARLHLVASGTAVAGDVVGRPRLAGEPVDEPLVDLPLPDADEVAGRLDGLARVVIAGGSAPALVTAAVVHGELLALRPFASYNDLVARAAERIVLINSGLDPKAICPAEVGHAEQGAEAYLEAFKGYVSGTAEGMAAWIAHCGRAVELGARESTAVCEALQRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWG8</accession>
    <name>A0A0F4JWG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000078">
        <property type="protein sequence ID" value="KJY38083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38083">
        <property type="protein sequence ID" value="KJY38083"/>
        <property type="gene ID" value="VR44_04280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24421" checksum="2D027CED9263C102" modified="2015-06-24" version="1" fragment="single">MSVRASAETGAGAEVPVLEGMPVLGSMLDLKTDSLGTYLRAQRRHGDVVRIDVGPPGLRMEMYCVFSAEGAQQVLASESAGFRKDNPFYEEIRDSFGNGLLTAQDADYLRQRRLVQPLFTRRRVDGYAAAVAEETAGTLASWARARDGIVDVSDEMMHLALRAVSRILFGADVDATVDVVHRCFPVITEYVLRRGYSPVNAPRSWPTPGNRRAAAALEELYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWQ3</accession>
    <name>A0A0F4JWQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_03860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000071">
        <property type="protein sequence ID" value="KJY38274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945927.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene770"/>
    <dbReference type="EnsemblBacteria" id="KJY38274">
        <property type="protein sequence ID" value="KJY38274"/>
        <property type="gene ID" value="VR44_03860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8675"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10435" checksum="44500682C3A922AE" modified="2015-06-24" version="1">MDEDVRMTAWVRGRVQGVGFRWFTRANALEIGGLAGFALNLDDGRVQVVAEGQRENCHRLLDWLRDGDTPGRVDGVTEIWGTPRGGYDGFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWR7</accession>
    <name>A0A0F4JWR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945839.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38580">
        <property type="protein sequence ID" value="KJY38580"/>
        <property type="gene ID" value="VR44_03350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7887"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471425" evidence="2">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="47187" checksum="D1524A94809517B3" modified="2015-06-24" version="1">MMAATKKIAGGLVATALVLCAAGCSGSGSAGRGAPGAPNGRKGAAAPEAPGSVNRPIGDGSTAYTGPQPNVEKPQKLKPGEKPPQFVVFSWDGAGEDSQKLFSHFREVGKEYNARMTYFLSGVYLLPEEKRSLYTAPQHSPGRSDIGFGDLQGIKDTATQVRAAWLEGNEIGTHFNGHFCGPDGGVGTWSVEEWKSEINQAKSFVKNWKTNAGLKEMDPLPFDYDKELIGARTPCLEGQKNFMLAAKDMGFRYDSSGISKQVWPKKTDGLWDLPLQLVPMPGRAFDTLSMDYNYMVNQSGTTTQGDPSQHQYWGDQMRDGLKQAFDRAYEGNRAPLIIGNHFESWNGGTYMRAVEESIKSMCGQKEVRCVPFRELADWLDAQDPKTLDWLRTLEVGQAPKEGWTKFLTAGPPAAPAAPTGKVKPAEGPAGEPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX89</accession>
    <name>A0A0F4JX89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945889.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38439">
        <property type="protein sequence ID" value="KJY38439"/>
        <property type="gene ID" value="VR44_03645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8267"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="21916" checksum="6E93463824D3A307" modified="2015-06-24" version="1">MSVMTEHPHLLTEDFEAVARIAAREVEGLRLEFIDGVIRSKAVPDGDHDRIVLWLARICMQHRPELWLHVERGLAVGDYRSGRARPDAALALDDAFVGQGEWADPAPVLMVVEVTSYDNDTDRRDRVEKPLAYAQTGIPVYLLIDREACDVIVFSEPDGRRYVNTRTVAFGKDIELPDPVGITLQTEPLKDWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXG5</accession>
    <name>A0A0F4JXG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945727.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38850">
        <property type="protein sequence ID" value="KJY38850"/>
        <property type="gene ID" value="VR44_02750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045045">
        <property type="entry name" value="RTM2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="PTHR43670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="15408" checksum="31FDF91004FB02D6" modified="2015-06-24" version="1">MLMRTDPFHELDRLTQLFNGVQRPAAMPMDAWREDGSVWVKFDLPGVDPDSVDLSVEEDMLTVQAERKPEVKEGADVVISERPTGTFTRQLFLGENLDTEHIEAVYDAGVLSLRIPVAEQAKPRKIEIGTGGSKELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY58</accession>
    <name>A0A0F4JY58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000051">
        <property type="protein sequence ID" value="KJY38779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945747.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38779">
        <property type="protein sequence ID" value="KJY38779"/>
        <property type="gene ID" value="VR44_02860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7302"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21947" checksum="1B6B610BE04B8795" modified="2015-06-24" version="1" fragment="single">GPAAAPIAGPIAARNPVVFVHGYNADPGVWGSLREALRADGYADSELFSFGYDTHQSVNEVLSGRLAAHVDEVRRQTGAARVDIVGHSFGSLVSRWYVKYGGGTAAVDHWVSLAGPNHGTSTAWACALWDQACRDMTPGSYVVKNLASGDETPGTVKYATFWSDCDEVVNPDSSVPLSGALNTPVGCLKHNDLLGDGATSAGVRAFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ13</accession>
    <name>A0A0F4JZ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945411.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39632">
        <property type="protein sequence ID" value="KJY39632"/>
        <property type="gene ID" value="VR44_01070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2927"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="474" mass="48777" checksum="50DA251595716430" modified="2015-06-24" version="1">MGPLISCDDRPVTTLPHLPSEPTETGDHTGHEHASHGQAAGGSPGHGHGHGHGHSHGHGPAAPVSKHLRRVISAVLIPFAAAVFVGLVVLWPGGAPAHERTGVGFDRQTQQGKVVALADIDCKSVNAAQVPPGGKPAAPESQSAPGGACKRATVEVGTGPDKGRVFFEIVQPGAPRQLEKGQEVVVAYAPDAPRDLQYSVIDLNRKFPTALLAGIFAVAVVVVGRMRGLFALIALVVSFGVLTLFILPAILQGSNPLVVAVVGASAIMLIALYMCHGLTARTSVAVLGTLVSLLLIGLLGSLFIDWAFLSGNTDDNTGLIHGLYPDIDMSGLLLAGVIIGSLGVLDDVTVTQTSAVWELHQADSKMGPRALYRAAIRIGRDHIASVVNTLVLAYAGAALPLLLLFSIANSSMGTVANSELVAEEIVRTLVGSIGLVASVPVTTALAALVVSADRSGPAAAVPAARGGRGRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZG1</accession>
    <name>A0A0F4JZG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945485.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39495">
        <property type="protein sequence ID" value="KJY39495"/>
        <property type="gene ID" value="VR44_01445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4721"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14797" checksum="E988AFF959904882" modified="2015-06-24" version="1">MPDASAWRLALPHTAAAVPMARALVRTALTDTGPSADRDTAELLTAELVANAVEHTTAGAPIELVVEMLADGCQVEVHDGDPRPPRELVTRPREGHPDPWQEHGRGLFLLRALSSACGHRPTERGKAVWFTLPAGATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZY0</accession>
    <name>A0A0F4JZY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945280.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39922">
        <property type="protein sequence ID" value="KJY39922"/>
        <property type="gene ID" value="VR44_00225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.43"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="710" mass="78393" checksum="F0C17E025D97086D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0L1</accession>
    <name>A0A0F4K0L1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">VR44_00245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007265893.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4K0L1"/>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1008"/>
    <dbReference type="EnsemblBacteria" id="KJY39925">
        <property type="protein sequence ID" value="KJY39925"/>
        <property type="gene ID" value="VR44_00245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.47"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13770" checksum="EEBCFD98A4D04F8C" modified="2015-06-24" version="1">MPTIQQLVRKGRQDKVEKTKTPALEASPQRRGVCTRVFTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGALDTQAVKNRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4U8</accession>
    <name>A0A0F4I4U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_40445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001749">
        <property type="protein sequence ID" value="KJY16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16493">
        <property type="protein sequence ID" value="KJY16493"/>
        <property type="gene ID" value="VR44_40445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="20432" checksum="BA176B740612E664" modified="2015-06-24" version="1" fragment="single">MYRGMELAGRYRLDSRLGHGGMGEVWAASDLRLRRTVAIKTVLTSHLRDDRLAAQVLARFRREGEAAARLNHRNIAVVHDLGEHRETSADGQVEVSPFLVMEFLEGRDLATVLREDHPGGLPLEQVVEYGAQVCDGLAAAHTQNIVHRDIKPANLMLLEDGTVKICDFGIAQLQDGTIGLTMTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6Y1</accession>
    <name>A0A0F4I6Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001684">
        <property type="protein sequence ID" value="KJY17218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17218">
        <property type="protein sequence ID" value="KJY17218"/>
        <property type="gene ID" value="VR44_40095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="13767" checksum="EF0EAAF9E6F115A8" modified="2015-06-24" version="1" fragment="single">MDTPLPPAHELALIDAELVRLDARRLHLLARRDWLLRLLWQQGGAQPGPAAGVGGPAGGAFGPPAAPFSPAAPFSPVASAAAKPGAQNVLLVLGAVLLAVAALAFTLVSWGSLGIGGRLAALAVVTAAALAAPVVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I777</accession>
    <name>A0A0F4I777_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001676">
        <property type="protein sequence ID" value="KJY17318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17318">
        <property type="protein sequence ID" value="KJY17318"/>
        <property type="gene ID" value="VR44_40025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="21323" checksum="D19F95DF76AE4882" modified="2015-06-24" version="1" fragment="single">LAATERVALNLQRALVADPGRPHPNLLIAGRYLPVGPSALVGGDWFETVRLHFGRTLLVVGDVMGHGLDAAVDMNAYRSTLREVASTELAPHRVLRQLDALVAEDAARRPATCLLARVDPARGTALFASAGHLPPAVFAADGTGRLLDVPVGPPLGTGLGGYESAAHPLTHEETLVLYTDGLVERRGEDIDDSLALSLIHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7C2</accession>
    <name>A0A0F4I7C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001672">
        <property type="protein sequence ID" value="KJY17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17363">
        <property type="protein sequence ID" value="KJY17363"/>
        <property type="gene ID" value="VR44_40000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6337"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13051" checksum="A7B28001F99B1143" modified="2015-06-24" version="1" fragment="single">AACDAADREALTELLDSLDRPLTAVVHAAGVLDDGVIGALTAERVAEVMRPKADAARHLHELTQDCDLSAFVVFSSVAGVFGSAGQGGYAAANSYLDALMAERHAAGLPGLSLAWGLWTGVGGMGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE13</accession>
    <name>A0A0F4IE13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001574">
        <property type="protein sequence ID" value="KJY18896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18896">
        <property type="protein sequence ID" value="KJY18896"/>
        <property type="gene ID" value="VR44_39320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5666"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="14180" checksum="CCBCFD88F1B23BF8" modified="2015-06-24" version="1">MRGGAGGLLDGARVSAGARAALRADAGRYTWAAAAVGSQNAASYQLASGRPVMPLGGFNGSDPSPTPERFKAYVKAGKIHYFIAQGGLEGAGELRTGGRAGGQGGPGGSASTAIDSWVRANFKAVTIGGTTFYDLTAPSTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFJ2</accession>
    <name>A0A0F4IFJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001513">
        <property type="protein sequence ID" value="KJY20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952385.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001513.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20243">
        <property type="protein sequence ID" value="KJY20243"/>
        <property type="gene ID" value="VR44_38770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_C" evidence="1">
        <location>
            <begin position="183"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="29573" checksum="F284BA327730DCE2" modified="2015-06-24" version="1" fragment="single">MRELAETARQWVAEGRVAFLARPVTEQGFGPRDPAGAVLVDARGECAGALYRGVFDAELVAEAGAIGAGGGARVCEVSVGAGEATEAKLTCGGQAEVLLQPLSTIPAEWWELLGTGAGVALVTRLNEGADAAVSEVVRAGGLPADDAARRAGELLGTRRPGRDALYGGSGLVLVEAYPSAPYVVIGGAGELAEVIGAQAALLGWESVTVGSAGEAEKVLVQHRDAACLVLLSHEPDFDVPSLRTALALGIPYVGALGSRRTTARRREGLLAAGVGEAELARVHGPIGLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGD6</accession>
    <name>A0A0F4IGD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_38565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001487">
        <property type="protein sequence ID" value="KJY20739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952346.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001487.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20739">
        <property type="protein sequence ID" value="KJY20739"/>
        <property type="gene ID" value="VR44_38565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5366"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY20739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9560" checksum="7A34DF31D3F316C2" modified="2015-06-24" version="1">MGIIAWILIGLLAGLIAKALMPGKDPGGIIVTTLIGIAGGLLGGWLGKVIFGVDSIDGFFDLSTWIAAIVGSVILLALYRLLTGNRHSHRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIK2</accession>
    <name>A0A0F4IIK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ToxA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001455">
        <property type="protein sequence ID" value="KJY21499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952291.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001455.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21499">
        <property type="protein sequence ID" value="KJY21499"/>
        <property type="gene ID" value="VR44_38275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5264"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="26937" checksum="E14BEFE51321948A" modified="2015-06-24" version="1">MSGQLYDGIGEAFEGFKTLPVIRYAEVPGFLALVGDVTGKSVLDIACGTGFYSRELKRRGASRVFGFDISGAMVDAARASERDEPLGIEYQVADTATLQVFDEPFDVAVAVQAFNYASEVAEIELMMRNIRRSLVAGGSFFLFVQDPSYDFGGPSLEKYGFLFESTGKDNEIGRGIRLTALLDPPVSFEAVVPSKETYEQTLTAAGFTGIEWVTLEVSQAGVEKFGEEFWADYTGNRPLTMIRCTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM58</accession>
    <name>A0A0F4IM58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001409">
        <property type="protein sequence ID" value="KJY22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952196.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22764">
        <property type="protein sequence ID" value="KJY22764"/>
        <property type="gene ID" value="VR44_37770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5060"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="19"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="482"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="689" mass="76058" checksum="BB22273A266071E8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP57</accession>
    <name>A0A0F4IP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001352">
        <property type="protein sequence ID" value="KJY23825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952084.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23825">
        <property type="protein sequence ID" value="KJY23825"/>
        <property type="gene ID" value="VR44_37150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4819"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="32884" checksum="6D9B6462F5320479" modified="2015-06-24" version="1">MSTDPAPVPRVSREEFDALFAEVRTWGRWDPAGRGAWNRVTPAHVRRAAALVRDGTTVPLGRPWDTRPAPDNLRPALHHMTDLGDVEPPEPSAHKDFLGADYHGKSVSHLDALSHIAYRGELYGGRPARGWVGAGGARFGSVADLGPLVTRGVLLDLPAVLGAAWLEPGRAVRADDVLAAERTLGADIDEGCAVLLRTGRFRRRRERGPWDPDAASAGFHVDAVPLLAERGVSLLGSDGDSDLRPSPVEGLHSPVHTLALTAMGVPLLDNLDLEGLSTACAGAGRYAFLLVVTPLNVPGGTGSPVNPVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ52</accession>
    <name>A0A0F4IQ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001357">
        <property type="protein sequence ID" value="KJY23804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952091.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001357.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23804">
        <property type="protein sequence ID" value="KJY23804"/>
        <property type="gene ID" value="VR44_37190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4829"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25137" checksum="006F823ACE14C8DA" modified="2015-06-24" version="1" fragment="single">KLTSVRSTLWTLGSLVALVVGVGMLAVVQTASQDYEKLPYTAPALFGLMVGQIAVIVLGVLTISSEYGTGLIRTTFTAAPDRLRVLTAKYLVFGTVALLTTTLSVGFVGLWAAILHSGPAAGPHGLAEWAGALAGCFYVTLLGLLAMAVGALVRHSAGAIAVMLGVVTMPPVLGSILMVWPVTSGVGGLVLRYNAPVGLFQLFGVQDNGVGGAAMPSDLAQMTLLVLVTAAAVTASYAVVRRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR20</accession>
    <name>A0A0F4IR20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001228">
        <property type="protein sequence ID" value="KJY24437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5940"/>
    <dbReference type="EnsemblBacteria" id="KJY24437">
        <property type="protein sequence ID" value="KJY24437"/>
        <property type="gene ID" value="VR44_35370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4187"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="79"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="36191" checksum="8BB8D2605360AB40" modified="2015-06-24" version="1">MNSTAGDHSGDAPIGFADYDQVPEGHFYDPDAEYEPDPEYAATLAPDAARQRRERIGPTGRPLPYFPIPGPLTDHGPAKIIAMCNQKGGVGKTTSTINLGAALAEYGRRVLLVDFDPQGALSVGLGVNPMELDLTVYNLLMERGMSADEVLLKTAVPNMDLLPSNIDLSAAEVQLVSEVARESTLQRALKPLMNDYDYIVIDCQPSLGLLTVNALTAAHKVIVPLECEFFALRGVALLTETIEKVQERLNPELELDGILATMYDSRTVHSREVLARVVEAFDDHVYHTVIGRTVRFPETTVAGEPITTYASNSVGAAAYRQLAREVLARCPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX9</accession>
    <name>A0A0F4ISX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C1 regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001172">
        <property type="protein sequence ID" value="KJY24764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951566.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001172.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24764">
        <property type="protein sequence ID" value="KJY24764"/>
        <property type="gene ID" value="VR44_34355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="31496" checksum="BAEB5A09EE89B4D3" modified="2015-06-24" version="1" fragment="single">MAASPHSPNSSFRRLRGAHSPAEFAAMVRRAAREIGETVSCDARYIGRVESGEIRCPNYAYERVFLHMFPGRTLADLGFSPREAVRGRAAQRALPTPPVFTHLIHRSKESDVLRRAFMAGGSATMAAATLSLTLLGDSRRIPSRAGEAEADAVEDAVRQIRLLDDRHGADALYRRAAQPLRTAYALLDAGATRQSTEDRLHSGAGELAVSVGWLAHDSGRFEDARSHYAEALATARVAGDAGLEAHAFSNMAFLARDCGRPRESVRAAQAGRRAARSLGSPRLLSLLALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT17</accession>
    <name>A0A0F4IT17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001347">
        <property type="protein sequence ID" value="KJY23851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23851">
        <property type="protein sequence ID" value="KJY23851"/>
        <property type="gene ID" value="VR44_37070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4802"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13735" checksum="5C7221B5A0FDC2A0" modified="2015-06-24" version="1" fragment="single">IDTVRRRTRAPEGGPGGGAADGGRAVRSGDVEVDPAGRTVTVAGREVRLTRREFDVLALLAARPDEVHAREEILDRIWGDAFLAASRSLDVHVAGIRAKTGRPGLVRTVRGFGYQLGAAPAVRGERDAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITS7</accession>
    <name>A0A0F4ITS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001153">
        <property type="protein sequence ID" value="KJY24888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951512.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001153.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24888">
        <property type="protein sequence ID" value="KJY24888"/>
        <property type="gene ID" value="VR44_34080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3743"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7088" checksum="2E344430655D7A84" modified="2015-06-24" version="1">MSTATDTLLKVEKGNAAPEELAAITAILLARAAATPEEAAPTRRSTAGWRRLERSRGFQAPHSWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITU8</accession>
    <name>A0A0F4ITU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001289">
        <property type="protein sequence ID" value="KJY24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24116">
        <property type="protein sequence ID" value="KJY24116"/>
        <property type="gene ID" value="VR44_36285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4505"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="15848" checksum="2469476F88623B63" modified="2015-06-24" version="1" fragment="single">MTETISAPQALAPATGPTPQKLKRSIGVVGGTLLTLSCVTPASTLFVVVPDLFSSLGTWTALTIAIGSLLCIGVAFCYSELGTLIPSAGGEYAMVSTLAGRLAGWLVFVLSLLVVMIVPPVIAMGTADYLAPVVHIPAPVAGGAVMLLATLAGLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU63</accession>
    <name>A0A0F4IU63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001058">
        <property type="protein sequence ID" value="KJY25550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951165.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25550">
        <property type="protein sequence ID" value="KJY25550"/>
        <property type="gene ID" value="VR44_32195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3160"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28383" checksum="958D1646F4032C62" modified="2015-06-24" version="1">MSNDDQYGGGAVGGTGQTRTRLPDPPSDPYGTPRRTPRASRGLITVVGVVVLLIAAIAFANQSQDTAQPPTSDKPPTTNATSPTGTPPVTTKSAGIPKGFAHDEQGAQSAAANYTVALNSDGMLKKDVRHALMDGLYTPEAAAQRKGGQDTAYSPAFFASLGLDANGNAPQGNTFVTRAVPVGTRVESYGPANAKVSVWYMALVGMTGAKSTTPVTTTWKTWTFELTWAGDDWKVASDSQQDGPAPVPGDVPASTSDDISKAVQEFGGFTYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUQ5</accession>
    <name>A0A0F4IUQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951250.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25374">
        <property type="protein sequence ID" value="KJY25374"/>
        <property type="gene ID" value="VR44_32665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6907" checksum="12E67052698EFB68" modified="2015-06-24" version="1">MSRPSTSSLLGQCPGVADPAWAAVRDLAREILFVLTGDRTLPMPEINVIPATSDTAAPLPVDHVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVH3</accession>
    <name>A0A0F4IVH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001182">
        <property type="protein sequence ID" value="KJY24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951605.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001182.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3255"/>
    <dbReference type="EnsemblBacteria" id="KJY24691">
        <property type="protein sequence ID" value="KJY24691"/>
        <property type="gene ID" value="VR44_34610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3907"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="29551" checksum="3BF7ACDA792FC7BC" modified="2015-06-24" version="1">MPTPAELISPRSPRVAAARRLARRNFRTKERRFLAEGPQAVREAVAHRGSQGATLIELFATVEAAERYADIVEAALLGGARVHYASDEVLAEVSQTVTPQGLVGVCHFLDSPFEEILGSGPKLVAVLAHVRDPGNAGTVLRCADAAGADAVVLTDASVDLYNPKSVRASVGSLFHLPVAVGVPVEQAVAGLREAGVRILAADGAGQDDLDAELDAGTMGGPSAWVFGNEAWGLPEETRALADAVVRVPIHGKAESLNLATAAAVCLYASARAQRAPGGCRSVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW17</accession>
    <name>A0A0F4IW17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001020">
        <property type="protein sequence ID" value="KJY25829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951033.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25829">
        <property type="protein sequence ID" value="KJY25829"/>
        <property type="gene ID" value="VR44_31500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2795"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20945" checksum="7A3AC6EF56431048" modified="2015-06-24" version="1">MTERKPRKDAARNRQAVLEAADALFGRCESPEELTMADIAAAAGVGKGTLFRAFGDRTGLLRALYEARLEPVREAVETGPPPLGPATPPRERVPALLDALLCFKLDNRRLALALEETGSSSPYQAGHYDWWHGVLRSALEEVPGMADAGFAAHALLAATRADLVERLAGREGVERERLRAQLAGYAARFLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWQ5</accession>
    <name>A0A0F4IWQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001119">
        <property type="protein sequence ID" value="KJY25111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951388.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001119.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000129_gene7434"/>
    <dbReference type="EnsemblBacteria" id="KJY25111">
        <property type="protein sequence ID" value="KJY25111"/>
        <property type="gene ID" value="VR44_33390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3556"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="444"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="529" mass="56633" checksum="8EE940D89082A993" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWR3</accession>
    <name>A0A0F4IWR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000935">
        <property type="protein sequence ID" value="KJY26480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950753.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000935.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26480">
        <property type="protein sequence ID" value="KJY26480"/>
        <property type="gene ID" value="VR44_29950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2372"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="34440" checksum="2270C471CC4BF691" modified="2015-06-24" version="1" fragment="single">MSYDATPDPYSDPLVFGQRMQILRTRRGLTRDQLGGLLGRSGSWVKAVETGRLRTPHLPIVLRVAEVLRVRNLSELTGDNTLQADLFAGPGHPRFAEVREALNSLNLGSTHEAPPVAHLTARLSRAWAARHSAPDHREVVGALLPGLIRDAQASVRQAETVADRKAAQARLAETYFLAQFFCAYQPDAPLVWRVAERGMTAAQDSEDPHAIGLAAWLTTQAHRDSAHYEAADAVTLETLRYLTPLLPDATADVRAVAGALTVEAGLTAARRGETGTAWHHWDQARLLAETLPPAYFHPVTSFSRAVIGAHAVSVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWV2</accession>
    <name>A0A0F4IWV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000980">
        <property type="protein sequence ID" value="KJY26119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950914.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000980.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5945"/>
    <dbReference type="EnsemblBacteria" id="KJY26119">
        <property type="protein sequence ID" value="KJY26119"/>
        <property type="gene ID" value="VR44_30840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2626"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="237"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="617" mass="68729" checksum="BFA8A889A0C22150" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWX4</accession>
    <name>A0A0F4IWX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">VR44_29895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000931">
        <property type="protein sequence ID" value="KJY26512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2659"/>
    <dbReference type="EnsemblBacteria" id="KJY26512">
        <property type="protein sequence ID" value="KJY26512"/>
        <property type="gene ID" value="VR44_29895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2359"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="315"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY26512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="547" mass="60755" checksum="BD23C67B4E6EE488" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYP1</accession>
    <name>A0A0F4IYP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950469.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000868.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27117">
        <property type="protein sequence ID" value="KJY27117"/>
        <property type="gene ID" value="VR44_28405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2006"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="37702" checksum="721C40452D12A34A" modified="2015-06-24" version="1">MIVWINGAYGAGKTSTARELAGLLPDSTLYDPELIGDALRRLLPGKRLAEVDDHQDLPSWRRLVVDAAAAVLAEVGGVLVVPMTLLRQEYRDEIFGALAARRITVRHVLLAPAETILRERMAGRREEGERGRRQGAHDHLPAYRQALGWLTADAHVIDNGRLTPRETAQRIAEAVTTDTAAVCDIVQTPEPTRETVAAGVLLFDDRDRVLLVDPTYKAGWEFPGGVVEAGEAPARAGVREVAEELDLTLDRVPELLVVDWEPPRSPAYGGLRLLFDGGRLSEPQAARLRLPGPELRAWRFVTEEEAAGMLPPQRYERLRWALRARERGRPLYLEAGRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ00</accession>
    <name>A0A0F4IZ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000855">
        <property type="protein sequence ID" value="KJY27250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000855.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27250">
        <property type="protein sequence ID" value="KJY27250"/>
        <property type="gene ID" value="VR44_28055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1824"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21266" checksum="C5A9EB4DBF8C4522" modified="2015-06-24" version="1">MGNREDLLAGARRCLEEKGYLRTTVRDIASAAQVSMAAIGYHFGSREVLLNQALFAAMEEWAAGAGRLTGQGDTAEQRYADTWDRKIRDFGEMSWLWTASVEAFVHAQSSPELLAILAEGQRRNRRMVAAALRGVPEEAVTEEDVRSLGSLHIALLSGVMVQALTDPEHAPTGTELVQGLRTMVELLGEPARTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZL5</accession>
    <name>A0A0F4IZL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000832">
        <property type="protein sequence ID" value="KJY27455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27455">
        <property type="protein sequence ID" value="KJY27455"/>
        <property type="gene ID" value="VR44_27525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1673"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17359" checksum="70D1FFE09C24DC52" modified="2015-06-24" version="1" fragment="single">VKMGLGWEPAFGGRDIDLDASVIAYGPQRNFVDACYFGKLSILGGSVKHSGDNLTGEGAGDDEVIVVDLGRLPAEISGLVFTVNSFSGQKFTEVAKAYCRLIDAATDEELVRFDLTGAEPQTGVMMAKLIRQFSGEWEMTAMGDFVKSRTVRGMVKPAGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0A7</accession>
    <name>A0A0F4J0A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000848">
        <property type="protein sequence ID" value="KJY27329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950377.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000848.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene202"/>
    <dbReference type="EnsemblBacteria" id="KJY27329">
        <property type="protein sequence ID" value="KJY27329"/>
        <property type="gene ID" value="VR44_27885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1817"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="28446" checksum="EF684CF102986296" modified="2015-06-24" version="1">MGTVTRGTTNPNRLRRMDRWIAAVHGAALRRADAPVAVDLGYGAAPWTAVELLARLREAAPRVRVVGIEIEPARVAGAKPYEREGLSFRHGGFEVPLEGGERPALIRAANVLRQYEEEQVEAVWGRLCDRLAPEGLLVEGTCDEIGRRHVWVALGPEGPRTVTFATRLGSLERPSDLAERLPKALIHRNVPGEPVHAFLRDFDRAWAAAAPYASYGARQRWIRTARALAGDWPLADGPVRWRQGELTVRWEALRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0G6</accession>
    <name>A0A0F4J0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000842">
        <property type="protein sequence ID" value="KJY27384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950345.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000842.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27384">
        <property type="protein sequence ID" value="KJY27384"/>
        <property type="gene ID" value="VR44_27720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1781"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="42679" checksum="FA17BA0D497B0BC0" modified="2015-06-24" version="1">MSPATGSTPVISAAIMAHPRRLDEAGRLADTLRPWRARIAVDPDPHGPPTTLRTARAAWSLIGAGATHHLVLQDDVEPCRDFVRRVEAAALEHPDTPLAFYANWNSWNGAATRAAALQGASWVPAVPGEWVPTLALLLPRHDVEALLSAVSGEDAAPEPDDVVVARELAARRRSVLISVPHLVEHVGSASIIGNDRYGPRHSACFADDVPDAPPGRPGAAGTLPQTPPVLVHRPHGHAHVVLTTPDGADGEPLFLSRQAYLRGTPAAGRAQERWTRARASLSGLRVPAELMWLCEEIWHGGYLMGLHTPPTGHPPSPALVRVALRSWILGGSAGDPDRRLWIEQRLARLTGLAEEAFTAGRDDRRAHGPLPALPQERLAGLPAARHIWRDPQLALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0R1</accession>
    <name>A0A0F4J0R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="10" type="ORF">VR44_27880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000848">
        <property type="protein sequence ID" value="KJY27328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene201"/>
    <dbReference type="EnsemblBacteria" id="KJY27328">
        <property type="protein sequence ID" value="KJY27328"/>
        <property type="gene ID" value="VR44_27880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1816"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="9">
        <location>
            <begin position="61"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="253"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="48830" checksum="B4503D099B66DE8D" modified="2015-06-24" version="1">MSQYVSRLGGSISGRIAAARGARQDAPRLRLPAVGHHRKPRRVAMLSVHTSPLHQPGTGDAGGMNVYIVELARRLAAINIEVEVFTRATTGGLPPVVELAPGVLVRHVDAGPYEGLAKEELPAQLCAFTHGVMQAWAGHRPGYYDLVHSHYWLSGHVGWLAAERWGVPLVHAMHTMAKVKNAALAEGDTPEPAARVIGETQIVTAADRLIANTAEEADELVRHYDADPGKVAVVHPGVNLDRFTPGDGRAAARARLGLPQDAVIPLFAGRIQPLKAPDILLRAVAELVDRDPSLRGRLFVPVVGGPSGSGLAKPEGLQKLAAKLGITDLVHFHPPVAQDQLADWFRAASVLVMPSYSESFGLVAIEAQATGTPVLAAAVGGLPVAVDDGTTGILVAGHDPVDYARALRRFVDEDGLTARMGAAAARHAQHFGWDTAASGTADVYTAAMHDHRRRVRSHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Y0</accession>
    <name>A0A0F4J0Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000839">
        <property type="protein sequence ID" value="KJY27403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950334.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000839.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27403">
        <property type="protein sequence ID" value="KJY27403"/>
        <property type="gene ID" value="VR44_27660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1768"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010773">
        <property type="entry name" value="Mycophage_PG1_Gp7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07098">
        <property type="entry name" value="DUF1360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17254" checksum="4D4F43008A797865" modified="2015-06-24" version="1">MNLHREARAYAGDADRPLAAYTGLMGLYAGTVLGIAAAARALRRPLPQPGPWDVVLNAVATHQLGRLITRDPVTSPLRAPFTRFEGTSGPAELKEEVRGTGARKAIGELLTCPFCTGLWVATGITAGTLLAPRPTRLATATLAALAAADFLQLARAAAQRGAGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2B3</accession>
    <name>A0A0F4J2B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000787">
        <property type="protein sequence ID" value="KJY27893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27893">
        <property type="protein sequence ID" value="KJY27893"/>
        <property type="gene ID" value="VR44_26525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1429"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="73"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22101" checksum="74A7D6EEDD9B30E3" modified="2015-06-24" version="1" fragment="single">ADMNVHRIRQVVGPQVPICLDAAQSIGHLPVSVAGLDVDFVVFSGHKAMALPGSGAVWARGLRGPRLRPGGWSGTPNTAGIASLAAALDWLDAAGLGRIERWTVALTALLTDGLDRMDAYEVLGCRTSLAAGSRVQRRRSLVTFRHRGIDSRDLGFILFSRGFMVRTDGHCQAGRDAEEGSVRVSMHVHNTPQEVEELLATLSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2E7</accession>
    <name>A0A0F4J2E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28425">
        <property type="protein sequence ID" value="KJY28425"/>
        <property type="gene ID" value="VR44_25430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="38121" checksum="DECA377D8FFBB06F" modified="2015-06-24" version="1" fragment="single">MTLTSDKFYIPYLIPAAILTLALAIRLPVIMRFWRIDPNVRSLSGLLLLGSAVFYFGRPKSLALLNSSTGVSNFAAPLVYSLLTMFCAYCLIMVIHWRGGDPRRVRRTTWTIWSVYAGVVAGLWITFAFADVPVERLRDLDTYYAGTPWMREHILLYLAAHTAACLITATVIRTWLREVAGWLRAGLVFLVIGFVLNLAYDAVKLIAIVARWTGHDLDWLSTYVAPPIASVCALFVAVGFILPHAGQATQVLWTDYRQYRSLAPFVRELDGLDTGSLRLPRRTPLSRRLVQRRTQISDGLLRLQPYMDPGVRDRALAEALARDEAPDRAAATADAVAVVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2L3</accession>
    <name>A0A0F4J2L3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ORF">VR44_28250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="JZWV01000861">
        <property type="protein sequence ID" value="KJY27186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950438.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000861.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27186">
        <property type="protein sequence ID" value="KJY27186"/>
        <property type="gene ID" value="VR44_28250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1893"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="30415" checksum="445B38C92C72D65D" modified="2015-06-24" version="1">MSEPASIALQQEIARELEVAETFDAEREIERRVAFLAERLTSTGLRSLVLGISGGVDSTTAGRLCQLAVERARAAGHEARFYAMRLPYGVQADEHDAQLALSFIRADQVLTVDVRPASDAALEAARAAGVEFRDAHHQDFVHGNIKARQRMIAQYAVAGAHGGLVVGTDHAAEAVSGFFTKFGDGAADLVPLTGLTKRRVRAVADALGAPAELVWKVPTADLETLDPGKADEDALGVTYDDIDDFLEGKPVDARAFETIVRRYRLTDHKRRLPIAPGHAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3A8</accession>
    <name>A0A0F4J3A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000841">
        <property type="protein sequence ID" value="KJY27391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27391">
        <property type="protein sequence ID" value="KJY27391"/>
        <property type="gene ID" value="VR44_27705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8783" checksum="7CD5DD0021F14497" modified="2015-06-24" version="1" fragment="single">AGHTGSDTLALLRWPVLLLIVTALILVLYRTGPRPARGTRRCLPGGVLAALLWLGASGLFTLYAEAGTYNRLYGSLAGTIAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3I5</accession>
    <name>A0A0F4J3I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28263">
        <property type="protein sequence ID" value="KJY28263"/>
        <property type="gene ID" value="VR44_25805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1265"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="185"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="41966" checksum="896AEEF5AE7FFA91" modified="2015-06-24" version="1" fragment="single">VLPLGGGRAAVMWHADDRRGPPVTRALARLDQLAVFEEDLVAGTTVWSAQAYPVFGLHPEDAAVPLRSLGARLHPEDRERLEGLLGSLTDRHEGGQVLVRVLRPGGGMRRVRVAAEPVLTGSMLTGITGVFQDVSAQHHTEVALTATYDQLSAARTEAELRDQLVLGLQHAIVPEAPALETPPGLRVAARYRPAAAEYRVGGDWYDVQSLPDGKVLVTVGDIAGHGIGSATAMIALRGALHGLAFTGNSPGRLMEWLNEVTLRTPGQPTATAVCALFDPADRSLAWSGAGHPPVLLLRGGRARFMEDASNVLLGALPGAGYGETYTGLRSGDTLLLYTDGFVERRHVGLDESLEALRRAVERLPPGPAEELADRLMAAVLGDTDDDTSLVVVQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J518</accession>
    <name>A0A0F4J518_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000651">
        <property type="protein sequence ID" value="KJY29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266936.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7547"/>
    <dbReference type="EnsemblBacteria" id="KJY29355">
        <property type="protein sequence ID" value="KJY29355"/>
        <property type="gene ID" value="VR44_23150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.569"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004212">
        <property type="entry name" value="GTF2I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51139">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13555" checksum="3FDED9BFF3474EE4" modified="2015-06-24" version="1">MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSELMREVSDELSLAELAQSAAASEPVPAPVRPMLNSVSVASVTGGPERVTIKAPVEAVNVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5C1</accession>
    <name>A0A0F4J5C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000689">
        <property type="protein sequence ID" value="KJY28953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949671.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000689.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28953">
        <property type="protein sequence ID" value="KJY28953"/>
        <property type="gene ID" value="VR44_24085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="20337" checksum="C59D57B71DC1B361" modified="2015-06-24" version="1">MTARAPQSSRLDACISPTARDALAPGSRDRLIAQESLRIRWHQLFDRIPLLSARLPDTTDLYEAFLEWAVAGHRRLDWRMHLHFLEFLEGRDGGGAGIPLRPQDHIELLAASAARWFASPEHRQRGLALTTAALAPKVVVALKGNAPLERGRVKLAQLPGLEPAPGIHWALSGPGDFAVLTWSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5G2</accession>
    <name>A0A0F4J5G2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_22965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29425">
        <property type="protein sequence ID" value="KJY29425"/>
        <property type="gene ID" value="VR44_22965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.530"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="47348" checksum="B0AD25E7A0672428" modified="2015-06-24" version="1">MVWNKLDYDTRQLIEASTYDRMAWQEKIFATRKSLCQQGYFTGHEARLLALWNLHNAEASAKLLPPLRSRFAEVVVDEAQDCSAADLAILQLLHDAGLPLILVGDPDQAIYAWRGAEPHALGNFAARLSHTPHRLTGNWRSSPVICHLAATLRTGQRPPDTSVMRDEDIPVLLLPTRFATSGSRHLHSPTGDNIVDVFRARAEEYAIEAKDCLVTAYKYATLPGIAREKPNTNAITSLAWARTTVHTTGASSDDLARACAIAVRTLFGYWYPGETGGLDRIMAAHRLSAGQIHRTAFAFLYSLPAPHKEWGPQVWQAMKAWPPLPGAAPQGGKGRPAGKPTLARSQLATGVRTNIVHQLKGDEADGVLLLLPDLGSVQRWATSDPATDEVLRVWYVAVTRARRLAAIALPEEEIDALAQLLKGRQVPVRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5S4</accession>
    <name>A0A0F4J5S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29540">
        <property type="protein sequence ID" value="KJY29540"/>
        <property type="gene ID" value="VR44_22650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.462"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="18639" checksum="F531D7C47AEEA812" modified="2015-06-24" version="1">MTTPTPTPTPTPAPASLLLTDIERAVRGSWSAETCTPEYRSRWTPDNPARDQCGVTAMVLNDLLGGEVVRGEVHVDGVRVDYHWWNRLGAGVDVDLTREQFGPEEIVTGGVVIPRPPVAEWRRLREEYELLRERVLAVLDRRRAAAAGETSRQEAAEHGRNDTSVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J672</accession>
    <name>A0A0F4J672_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949334.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000623.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29695">
        <property type="protein sequence ID" value="KJY29695"/>
        <property type="gene ID" value="VR44_22240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.333"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470417" evidence="3">
        <location>
            <begin position="31"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="450" mass="43795" checksum="F8B21ED1D8902C30" modified="2015-06-24" version="1">MKTQRRASAALVALLLSGAGVAVAASPAQAAETTFKVRCVPPAGGGDPVEGETTARITAPATAKVGDEVDVSWETVKPASNNTDLMVIPKDSVQPTGWLTASDGGGEAKVVGEKKNPEIPKKAPMVMSVMKGKLKLTKAGKITVTPGKYEVAVTFPFGTFVTKCAPVGEVKGGAVIDVSGGGTGGTTGGSTTGGTTGSTTTGGSTTGSTTGGSTTGGSTSGGSTSGGSTTGGSGGQTDFPGKAVDVTYDCGAVVPNGIKTPVTISAKKNGGDYALTVKTAKGAMASPMQLPAGALKPSMDIKLGGADSGTVKVTGPANAEPIPSGAPVSLTDMTGTYKPGKSGKVTLTPDQLSIDVTMTPGSTPINVPCKATGSGVSLELDTTAQPGGSGSTTAGPSAGGSSATASGGLAETGAQDDGGIRALALIAGTIVLLGAAVFTFTPWRRLRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7D8</accession>
    <name>A0A0F4J7D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949150.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5514"/>
    <dbReference type="EnsemblBacteria" id="KJY30090">
        <property type="protein sequence ID" value="KJY30090"/>
        <property type="gene ID" value="VR44_21285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8982"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="27814" checksum="4B5796E60B46C58C" modified="2015-06-24" version="1">MGGNEARFGEFVAVRRHGDRGVVAELVLDRPKAMNAVSTEMARSISAACDALAADSGVRVVVLSSTHERAFCVGADLKERNSLSDAELVRQRPTTRGAYGGVLELPMPTVAAVHGFALGGGFELALACDVIVADETAVVGLPEVSVGVIPGGGGTQLLPRRVGAARAAELIFTARRVEAAEALSLGLVDEVAPAGGDRARALELAAAMAANSPVGLRAAKRALRLGHGMDLAAGLEIEDAAWRTVAFSGDRAEGVAAFNEKRKPEWPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7T3</accession>
    <name>A0A0F4J7T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_20495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000564">
        <property type="protein sequence ID" value="KJY30432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949007.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000564.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30432">
        <property type="protein sequence ID" value="KJY30432"/>
        <property type="gene ID" value="VR44_20495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8810"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="466" mass="49618" checksum="E8AF37FE7DD2D06A" modified="2015-06-24" version="1">MRGLRPLTVAGARRRTEALLLVFVVGIAVFGHVSAGLAMNGELPQHLTSFVISMSLLSLVGHLGIRRFAAYADPLIFPLAMLLTGLGLVLIHRLDQGYIERYGSDANAPGQLLWTVVGVAACLLVVALLRDHRLLQRFIYITMAVALVLLIAPAFFGADTYGAKRWIILFGFSLQPGEFVKIMIAIFFAGYLVIHRDSLALTGRKFLGMRLPPMRQLGPIITVWIISLLVLVFERDLGTSLIFFGVFVVMLYVATERTSWIVCGLVLAAGGAFVVGSTEPHVKARVAAWLNPLAIYSPNPPAGLNSEQSAQALFSFGTGGVSGTGLGMGHPELIKFAGRSDFILTTVGEELGLAGVMAVLLLYALLVQRGLRMALAARDPFGKLLAIGLASALALQVFVVAGGVTGLIPLTGKALPFLAKGGSSLLANWIMIALLLRISDSAERQREADARGPAETTITPVVVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J925</accession>
    <name>A0A0F4J925_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000578">
        <property type="protein sequence ID" value="KJY30263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30263">
        <property type="protein sequence ID" value="KJY30263"/>
        <property type="gene ID" value="VR44_20865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="33055" checksum="CF537DB29265FA6E" modified="2015-06-24" version="1" fragment="single">FVTSAATVPVDRWTHVAAAYEQSWALKFANGVYAEAPHASDLDIGRDLTLEVFLRTDSLSKAQGVLSKGRIDDGRGRKVPYQLGITTSGKLVFSFEDRDGKRVVHTSDKAVTAGTFHRIAVVRKLGDSREEKKSSRTTEMTVGGALTPVVMDVIESVAVRRWTEVSFHIDGEEAGTTRYDDAPDLSHPGPLEIGRARRGSTVESFSGEISEVRIWNVPRAAKDLGVDIPSAPQAPGAGAGPDEPGSVEAGVRPKGLVAHWRFEENEGNAAKDDSESHTARLHGAKWTKNPDPKGSRFRLYVDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9F0</accession>
    <name>A0A0F4J9F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_20610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000568">
        <property type="protein sequence ID" value="KJY30388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949027.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6937"/>
    <dbReference type="EnsemblBacteria" id="KJY30388">
        <property type="protein sequence ID" value="KJY30388"/>
        <property type="gene ID" value="VR44_20610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8836"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470285" evidence="9">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="446" mass="47315" checksum="55407B94E557A7DE" modified="2015-06-24" version="1">MTEVLLLVVALLLCLACGVFVAAEFSLTTVERSELERAVERGEHGADSALAAVRSLTFQLSGAQLGITVTGLVIGMISKPSIAALLTGPFEAMGLSASAASSTALVLGTVLSTVVLMVVGELVPKNWAISSPLAIAKRVATPQRVFSRAFRPLISHLNTTANHLVRRLGMEPAEELASARSPEELVALARHSAKAGSLEKDTAELFVRTLNLADLTAENVMTPRVQVTALDVQTTAEDVANATMATGLSRFPVYRGSLDTVVGTVHIKDVLALPAEERHRHPVSQLLREPLLVPESLTVDRLLDRLSGRQTMAVVIDEYGGTAGVATLEDIVEEVVGEVRDEHDPHETADLAPAGTDESGRVLYSADGAARTDQLRRIGLRVPEGPYETLAGLIAAELGRIPAVGDRLELDGWRLDVVDASGRRAARVLLHMPTGTAGDEGPEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9P3</accession>
    <name>A0A0F4J9P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">VR44_22275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949339.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene480"/>
    <dbReference type="EnsemblBacteria" id="KJY29701">
        <property type="protein sequence ID" value="KJY29701"/>
        <property type="gene ID" value="VR44_22275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.341"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="18589" checksum="30431D76CCD34A69" modified="2015-06-24" version="1">MSTSPAGPVVGIVMGSDSDWPVMEAAAQALDEFEIPYEVDVVSAHRMPREMVAYGEQAAERGLKAIIAGAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVATVSVAGARNAGLLAVRMLAAHDPELLGRMRDFQQELNDQATEKGKRLRAKVAGAEKFGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA18</accession>
    <name>A0A0F4JA18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000553">
        <property type="protein sequence ID" value="KJY30588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30588">
        <property type="protein sequence ID" value="KJY30588"/>
        <property type="gene ID" value="VR44_20035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8629"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="19586" checksum="E70F15C91284D5F7" modified="2015-06-24" version="1">MDVNRGHEDPERGGVPVPDTGAMVDEHGRPPGVPSRTGTGAGAAADPARVDAARLPEGPMAEAESEAEVNVLVSHCDREGAEAVLGVLAEAFPDMTPPVTAKPPAGAATGTASAAPSIWAVTVDARRRAPGAVLRRARPASPVTAELDGAAEPVRRVRDVLEHAFAGEHLGTVSGEHELQVALRLTARDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC54</accession>
    <name>A0A0F4JC54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000557">
        <property type="protein sequence ID" value="KJY30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948954.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000557.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5307"/>
    <dbReference type="EnsemblBacteria" id="KJY30546">
        <property type="protein sequence ID" value="KJY30546"/>
        <property type="gene ID" value="VR44_20195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8744"/>
    <dbReference type="eggNOG" id="COG1938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="34448" checksum="C85AA0A3FA903BEC" modified="2015-06-24" version="1">MRDPQGLYEWDAKGLAVADVALAQDSAGLVMLYHFEGYIDAGETGEQIVERILDTLPHQVVARFDADRLVDYRARRPLLTFQRDHWTEFEEPRLEVRLVQDATGAPFLLLSGPEPDVEWERFAVAVRQIVERLGVRLSVNFHGIPMGVPHTRPVGITPHGNRTDLMPGHRSPFDEAQVPGSAESLVEFRLGQAGHDVLGVAAHVPHYVARSPYPDAALTALEAITAATGLVLPAVAHALRTEAHRTQTEIDRQIREGDEELVSLVQGLEHQYDAAAGAETRGNMIAEPAEIPTADELGREFERFLAEREGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCB4</accession>
    <name>A0A0F4JCB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948347.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31977">
        <property type="protein sequence ID" value="KJY31977"/>
        <property type="gene ID" value="VR44_16955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7921"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="28257" checksum="474D68EE26D649A8" modified="2015-06-24" version="1">MRLYLAVAAGGFRRYAAYGTATAAGVFTNTVFGFIVAYTYVALWDERPHLGGYDQAQALTFVWVSQSLLAAGSLIGGGFQEELQERIRTGDIAVDLYRPADLQAWWLATDLGRAGFQLLGRGLLPLLAGALAFTLALPSDPLRWLLFLLSVALGLVVGFGVRYLLALAAFWLLDGSGVNLMATVVTIFFSGMLLPLTVFPGGFGEVVRLLPWAAMLQVPLDVLLGTHAGAGGAVRALGFQAVWAAVLLGAGRLVQSAATRKVVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDY1</accession>
    <name>A0A0F4JDY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000453">
        <property type="protein sequence ID" value="KJY31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948373.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3069"/>
    <dbReference type="EnsemblBacteria" id="KJY31943">
        <property type="protein sequence ID" value="KJY31943"/>
        <property type="gene ID" value="VR44_17095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7951"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="566" mass="62459" checksum="6CEA5D4998FA71C1" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE64</accession>
    <name>A0A0F4JE64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a0f4je64">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32480">
        <property type="protein sequence ID" value="KJY32480"/>
        <property type="gene ID" value="VR44_15840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7576"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="46078" checksum="F5F4C802D8D18760" modified="2015-06-24" version="1" fragment="single">MTAAPAAALPAADRSGPDPVVRTDHGPVRGAAHGSYATFDGIPYAAPPVGGLRWRPPAPAAAWHGVRDARAAAPRCVQMPPPGAAAGAVAGAEDCLYLNVTAPAPVRPAAGRPVLVWLHGGAFLGGSGGDYDAGRLAAGGGAVVVTVNYRLGIFGYFGHPGLGSAPPFGLADQQAALRWVRANAVRFGGDPDRVTLVGESAGALGICAHLTSPAAAGLFQRAVLQSGSCSMSFPRGALGPGSPAYEPFAAQRDVQAAGAQAARRLGCTAGRDEDVVACLRGQSTERLATAELMQSFNRPAYGNALLPAAPAEALREGRFHRVPLIQGTNRDEMRMFVGLSLAAFPIGTDAEYRARLVDAFGSTAAPAVEAQYPAAGYPTPALAWATVLTDRSLACTTLAAGRAVAAHAPGLPLYGYEFGEPEPPVPAGLPQNPGFPYGAAHGFELPFLFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE82</accession>
    <name>A0A0F4JE82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948313.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000445.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32053">
        <property type="protein sequence ID" value="KJY32053"/>
        <property type="gene ID" value="VR44_16770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17738" checksum="5D9DA5E5C96CB005" modified="2015-06-24" version="1">MTRTDVPSGVRSTPWRELASRHALLPLRIFLGVTFVYAGLDKLTTPGFLSASGAGSIGEQMRGVRDTAAVPALVDLALKAPSGFGLAIALGELLVGLGVLAGLLTRIAAAGGALISLSLWLTVSWAVTPYYYGNDLVYLVAWLPLVLAGAPYWSLDSLIRSRRSLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE91</accession>
    <name>A0A0F4JE91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948279.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32119">
        <property type="protein sequence ID" value="KJY32119"/>
        <property type="gene ID" value="VR44_16585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7749"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="726" mass="78397" checksum="C6A8BBB3D01FCA7D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEB9</accession>
    <name>A0A0F4JEB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000500">
        <property type="protein sequence ID" value="KJY31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000063_gene1465"/>
    <dbReference type="EnsemblBacteria" id="KJY31331">
        <property type="protein sequence ID" value="KJY31331"/>
        <property type="gene ID" value="VR44_18420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8234"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="28"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="42322" checksum="9F457C1EEE356A30" modified="2015-06-24" version="1">MCGMSGEPVTGLLMWDEAVTRYDFGPSHPMDPVRLALTMGLVRAFGLDREMEVRAAPAAGDSTLRLVHREDYVAAVREVSADPGVADGSYGLGTVDDPAFHGIHEASALIAGQSVAAAEAVWRGEAEHAVNFAGGLHHAMPGGAAGFCVYNDAALAIARLLELGAERVAYVDVDVHHGDGVQTAFWDDPRVLTVSLHEHPQTLFPQTGWPQETGGPAAEGSAVNVALPAGTGDEGWLRAFHATVPELLADFRPQVLVTQHGADTHFEDPLAHLAVSLDAQRAVQEACHGLAHEYAGGRWLALGGGGYAVVDVVPRSWTHLVGIAAHRPVDPAAMVPQVWRDEVYARTRQRGPARMTDGREAEWRDWDAGYDPADRTDQAVLATRRAVFPLRGMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEN3</accession>
    <name>A0A0F4JEN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000428">
        <property type="protein sequence ID" value="KJY32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948233.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000428.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32223">
        <property type="protein sequence ID" value="KJY32223"/>
        <property type="gene ID" value="VR44_16360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7729"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="27258" checksum="A745FBB4CF4A81F5" modified="2015-06-24" version="1">MTENPDTSGTTAEKTAGEGRVAVVSGGSRGLGRVLVERLLADGWHVATFSRSASDFVTEAMAAHPGSFHWEAVDLGEPETARTFVRNVHRVFGRLDLLVNNAGIVREELLFTMPPKAIESLITANLVAPIMLTQACARVMTRQGGGAIVNISSINAVRGYRGVSVYAAAKAGLDGFTRSLARELGGHGIRVNSVVPGYFDSAMTAEMPAASRARIERRTPLGRLAAADDVADAVLYLSSPRAEFVTGQSMVIDGGLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFS6</accession>
    <name>A0A0F4JFS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_15700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948109.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32608">
        <property type="protein sequence ID" value="KJY32608"/>
        <property type="gene ID" value="VR44_15700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7542"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16773" checksum="D4699398B85BA21B" modified="2015-06-24" version="1">MQTIWIGGAEWLAVLRIGLGLWWLESWRHKDKKGWFERGTGISWAADVAGKHRWSFVRSGFASVVQPRPRLMAYVVVYAELALGLGLVLGFLTPVALLGGLLLNLLYLVLMIHDWAEQGQNAMMALISGVAFFAMAWQTWSLDALIGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFX6</accession>
    <name>A0A0F4JFX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="10" type="ORF">VR44_15355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000397">
        <property type="protein sequence ID" value="KJY32704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948043.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000397.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3271"/>
    <dbReference type="EnsemblBacteria" id="KJY32704">
        <property type="protein sequence ID" value="KJY32704"/>
        <property type="gene ID" value="VR44_15355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7473"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="33266" checksum="C18F3BCBBA91DE22" modified="2015-06-24" version="1">MSAARKHTALPKAQILIEALPWLTRHNGKIVVIKFGGNAMIDEDLKAAFAQDVVFLRQAGLRPVVVHGGGPQIKAQLAKEGLVSEFKAGLRVTTPEAMDIVRMVLAGQVQRELVGLLNQHGPLAVGMTGEDAHTITATQHKPEIEGELVDIGRVGEITSIDTGAIEALLADGRIPVISSIARSADDGHVYNINADTAAAALAAALGAETLMVLTDVEGLYADWPNSDEVISRLTVSELEKLLPELSSGMVPKMEGCLHAVRGGVPTARVLDGRVPHSILLEIFTDQGIGTMVLPDPQPGADQPGTDRPDAPQGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG20</accession>
    <name>A0A0F4JG20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_15350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000397">
        <property type="protein sequence ID" value="KJY32703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948042.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000397.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32703">
        <property type="protein sequence ID" value="KJY32703"/>
        <property type="gene ID" value="VR44_15350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7472"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY32703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="27208" checksum="057E17612478C132" modified="2015-06-24" version="1" fragment="single">LLPGVETAAAALSADGGEAAAIAIKTTDTVHKTATAGQDGWTVGGMAKGAGMLAPGLATMLVVLTTDADLDSATLDKALRDATRTTFDRVDSDGCMSTNDTVLLLASGASGQVPAYEDFAAAVRAVCDDLARQLIGDAEGASKDIRIEVVGAASEEDAVEVGRSIARNNLLKCAIHGEDPNWGRVLSAIGTTKAAFDPDRLNVAINGVWVCRNGSVGEDRDLVSMKDREVHITADLSTGTESAVIWANDLTAEYVHENSAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGR5</accession>
    <name>A0A0F4JGR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_14890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000382">
        <property type="protein sequence ID" value="KJY32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947958.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000382.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32933">
        <property type="protein sequence ID" value="KJY32933"/>
        <property type="gene ID" value="VR44_14890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7394"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="973"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1067" mass="112863" checksum="7EFA9339BE40D1F4" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHN4</accession>
    <name>A0A0F4JHN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">VR44_14200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000366">
        <property type="protein sequence ID" value="KJY33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947840.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000366.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3360"/>
    <dbReference type="EnsemblBacteria" id="KJY33273">
        <property type="protein sequence ID" value="KJY33273"/>
        <property type="gene ID" value="VR44_14200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7187"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="16357" checksum="3AA312F7DEDFC508" modified="2015-06-24" version="1">MAARSNARKRAFQILFEADQRDVPVREVLADWIRHANADVRQPPVNAFTMDLVEGYAEKVNRIDDLIVTYAVDWELDRMPVADRNILRLGAYELIWVDETPDAVAIDEAVQLAKEFSTDDSPAFVNGLLARFKDLKPSLRRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHW1</accession>
    <name>A0A0F4JHW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948119.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32536">
        <property type="protein sequence ID" value="KJY32536"/>
        <property type="gene ID" value="VR44_15760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7558"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="32125" checksum="C3C3426FC9B4110E" modified="2015-06-24" version="1">MPPRKAPTARQRRLGSELRKIREQAGISMTDAASQLSTDRTNMSNVESGRFGVSSERVRTWARHYGCPDQAYVDALAAMADERGRGWWDDYRDELPASLLDLCELEHHAIALRSVQIMHMPGLLQTEDYARAVFEEAVPSLTPVDLRRYLSLRMRRRDVLDRKDMLSCDFLIHEAALRMKFGGRQVATSQLNYLLEQSERDNVTVRVIPFEAGGFPNAGGPTLYAYGPVPQLDTVQTDIPTGSVLLDAETRLANYRAVLDRTEHRAYGPERSRDFIREMAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIJ5</accession>
    <name>A0A0F4JIJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urocanate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_12835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000320">
        <property type="protein sequence ID" value="KJY34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947587.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000320.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene493"/>
    <dbReference type="EnsemblBacteria" id="KJY34005">
        <property type="protein sequence ID" value="KJY34005"/>
        <property type="gene ID" value="VR44_12835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6649"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="533" mass="57646" checksum="9FA4064A2C7D5FAA" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIR1</accession>
    <name>A0A0F4JIR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000316">
        <property type="protein sequence ID" value="KJY34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947563.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000316.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34070">
        <property type="protein sequence ID" value="KJY34070"/>
        <property type="gene ID" value="VR44_12685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6616"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="24304" checksum="B0A8C36F72F8FC43" modified="2015-06-24" version="1">MHGPGIPPQQGPHGHRPLSGAAMTLRVLFTALPLLSCGFFAWGSLLRIALLTRKTRDWVLLVLGGVLSVVWITFIELDPTEETNGWQGNLGAGGSIFTGFAICVYYLVADIKHHETKAAPPQAVGAAPWYPAQQTPYNQQHQQHLPQPPQQTRPSYGYPPVAPQQAPAPVQPPRIGQVRAELDELSELLRKQTPHAPQTPPRPPQPGGPYQDPNSTAVQDPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIX2</accession>
    <name>A0A0F4JIX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="7" type="ORF">VR44_12175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000299">
        <property type="protein sequence ID" value="KJY34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000299.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34297">
        <property type="protein sequence ID" value="KJY34297"/>
        <property type="gene ID" value="VR44_12175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6415"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="31585" checksum="59F13D7FA0E39777" modified="2015-06-24" version="1">MRMRPTLDWTPAADLPPGTTDLQPVTDALRAGGVLVLSGAGISTESGIPDYRGEGGSLSRHTPMTYQEFTASAGARQRYWARGHLGWRTFGRARPNAGHRAVAAFGRHGLLSGVITQNVDGLHQAAGSEGVVELHGSLERVVCLSCGALSPRRELAHRLEEANAGFEPVAAGINPDGDADLTQEQVADFRVVPCAVCGGVLKPDVVFFGESVPPRRVEHCRELVREAAALLVLGSSLTVMSGLRFVRQAADAGKPVLIVNRDRTRGDLQAVARVALPLGTALTTVAARLGVPVDGLGGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJH7</accession>
    <name>A0A0F4JJH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000327">
        <property type="protein sequence ID" value="KJY33918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947613.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000327.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33918">
        <property type="protein sequence ID" value="KJY33918"/>
        <property type="gene ID" value="VR44_12960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6709"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="42878" checksum="0B3E272A097BECEE" modified="2015-06-24" version="1">MTEHVHRSRPEPRPDRDFDLVLFGATGFVGALTAEYLALHAPAGCRWALAGRDPGRLERLRERLTALNPACAGLPLLRADASDGAAVRELAAATRVLATTVGPYVWYGAELVAACAAAGTDYVDLTGEPEFVDRMYVAHDARARETGARLVHACGFDSVPADLGAYFTVGLLPAGVPLRVDGFVRSSALASGGTLASALTALGRGPQTLAAARERRLYQPRLPGRRVRGPVGAPRFSRETGTWALPLPTLDPRVVTRSAAALERYGPDFRYRHYASVRHLPVALGGTAALGAAAALAQVPAARRWLMARWEPGTGPDAERRARSWFTVRFVGEGGGRRVFTEVSGGDPGYGETAKMLAESALCLAYDALPQTSGQLTTAVAMGDALLDRLQKAGIRFRVAAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJY4</accession>
    <name>A0A0F4JJY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000315">
        <property type="protein sequence ID" value="KJY34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34078">
        <property type="protein sequence ID" value="KJY34078"/>
        <property type="gene ID" value="VR44_12650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20382" checksum="2B8917BB0352FD9E" modified="2015-06-24" version="1" fragment="single">MPTPPCTSPSQQPAYSSWMRYFSPAPVHRRLGLVCLGVGVQQGVLPVVGPRVLDHHVAVVLTRGRGWFGHGGRPAQPVAAPALLWLVPGVEHHYAPDPEGGGWDESFVDFTGAGVGAYTDLGYITPDRPVVPLSGTTGVQHVVDGIVRAARRGGPLLEVEAAAQVPALLVALRYARAEVSRHGEAVVDALARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK37</accession>
    <name>A0A0F4JK37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate, phosphate dikinase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pyruvate, orthophosphate dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000267">
        <property type="protein sequence ID" value="KJY34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34702">
        <property type="protein sequence ID" value="KJY34702"/>
        <property type="gene ID" value="VR44_11480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers_C" evidence="3">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00032883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23743" checksum="3C886A5A447120DE" modified="2015-06-24" version="1" fragment="single">PPLHEFLPDRTELAVRIARQEAVGRAPAARDRALLSAVERMHEENPMLGLRGVRLGLVAPGLVAMQVRALAEAVVARKRAGGDPRAEIMVPLVGAAEELHLVRNEVDAVLADVAKESGVPLDCPVGTMIELPRAALTAGRIARDAHFFSLGTNDLTQTTWGFSRDDAEAAFFPAYLDRGVFERSPFETIDREGVGRLVEIAVAEGRASRPDLTVGVCGEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK70</accession>
    <name>A0A0F4JK70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947323.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34732">
        <property type="protein sequence ID" value="KJY34732"/>
        <property type="gene ID" value="VR44_11405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6178"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26250" checksum="694C684BEB438234" modified="2015-06-24" version="1">MATFVLVPGAWLGAWAWEDTARALRERGHTALPLTLTGLAEHADQGGPETDLDTHIADITGFVERNGLHDVTLVAHSYAAAPVTGAAGRLGDLLERVIYVDSAPFTAGMCMLDLMPPQAVDQLRRQVDASGDGWRLPMPPFEVLGLSSSLDGLDEGRQNVLRTRATPQPFGTFTQRLAGPAEPGPGVDRVLIACRDFTGLLDAGVPMLAYLNQPPWRRFDLPTGHWPMLSAPAELARVLDKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK72</accession>
    <name>A0A0F4JK72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_12430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947513.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34168">
        <property type="protein sequence ID" value="KJY34168"/>
        <property type="gene ID" value="VR44_12430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="193"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="31858" checksum="DA25BC8D79FB3429" modified="2015-06-24" version="1">MDTHRTTPGPGPLLCALERIEQAPQADTLIDGLRKGVRALPLGPARDLLHGRPLGHPAHPLLVQVPIGTWLSATVLDLLPGRARRTAAPVLVGVGLAAAAPAAAAGWADWAELPPEQARTGLVHALANTAGVALYAASLYARARGRDLRGRALALAGLAAVGAGGALGGHLAFRQAAGANHAEQVGHRVGDGWHPLGPAAAFPVGRAALAQVDGVDVLVVREEDGTVRALADRCSHMGGPLSEGGIEDGCVRCPWHRSLFRLSDGWNVEGPATAPQPAFETRVVEGLAEARLIRVHRPHRHGRGPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKF7</accession>
    <name>A0A0F4JKF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000302">
        <property type="protein sequence ID" value="KJY34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947482.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000302.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34258">
        <property type="protein sequence ID" value="KJY34258"/>
        <property type="gene ID" value="VR44_12245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6431"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="19970" checksum="B838688DEC4983D5" modified="2015-06-24" version="1">MTYPPQQGPGPYGQPGPYAQQPQGYPPQPGPGYPPPQAQPPYGGAPQQQMYPNQQMPMQPMPPQQWSAPPAPPARRGGIGAMKILKGIGIVVVLIVAAVGYFLSQDDADHAEAGDCLKNNGTTAATLDLQVVDCGSTGATYKVVEVISGTLDTNRCQGKSDLGYYEQTRGGRRSSGKQFVLCLNQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKR9</accession>
    <name>A0A0F4JKR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947754.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33551">
        <property type="protein sequence ID" value="KJY33551"/>
        <property type="gene ID" value="VR44_13730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7022"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="33387" checksum="ED4541BCE79F6768" modified="2015-06-24" version="1">MNTLSCEPRGTAALLVNAEGKYLLHLRDANKPWICDPGTWSIPGGNREGEESSRDAVERELLEETGLCVPLEPFTVVDAHGPDGSTGQIRVYLGAWDGDADALPCPEGIMFRWFDAARTQWLTMCPWTADVIALHQRSAPVPAPRTGKQPTRAGAGRPRLNTVGVHLYLQREDGAVLLGRRHEDCTFAPSMYQVLSGHCEQEAAIACVVREAQEEAGLVIDPADVELVHVVHMVDAPGTQPMIGLYFRARRWQGTPVVREPDRCASWGWWDCTDLPEPLVPYTRAAIEGIRAGRTYTELGWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKS9</accession>
    <name>A0A0F4JKS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947438.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34393">
        <property type="protein sequence ID" value="KJY34393"/>
        <property type="gene ID" value="VR44_12030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6491"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470649" evidence="1">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="17688" checksum="208DA44538FB61CA" modified="2015-06-24" version="1">MKTRSVLTALFLVLGALFAPGFGALSGTAQAQAATKITHATATSMFRQAGITWSSSGNCSDRDNPTCTSFEQLNLATAQGAQTLKSASGCALNITGGTETGHASGTYSHWNGYKLDYAKATCLTNYIKGTFAYIGVRGDGAPQWKSGSGNVYADEGNHWDVLYYNCGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKY2</accession>
    <name>A0A0F4JKY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947249.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34992">
        <property type="protein sequence ID" value="KJY34992"/>
        <property type="gene ID" value="VR44_11025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6089"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10215" checksum="812661DD375F11BB" modified="2015-06-24" version="1">MPGYTSHKDDVLKRLRRIEGQVRGLQRMVEEGTYCIDVLTQVSAATKALQSFGLTMMEDHLHSCVADAIAEGGDQARGKVEEASRAIARLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLB7</accession>
    <name>A0A0F4JLB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000280">
        <property type="protein sequence ID" value="KJY34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947366.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000280.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3705"/>
    <dbReference type="EnsemblBacteria" id="KJY34558">
        <property type="protein sequence ID" value="KJY34558"/>
        <property type="gene ID" value="VR44_11645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6295"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25076" checksum="E5AF4AC710A5A8D1" modified="2015-06-24" version="1">MTLFLHDVTLTYPDGDGRLTALDAVELEVPAGTLTAIVGPSGSGKSSLLAVAATLVTPDSGRVVVADRDTARLGAAEKAALRREEIGIVFQQPNLLASLTAAEQLQVMAHLSGRPARQLRRRALELLDAVGLADKADRRPHQLSGGQRQRVNIARALMNEPSVLLVDEPTSALDHERGAAVLDLLVTLTRERSTATVLVTHDHAHLDRMDRTATMTDGRLTHGARPAEPPAAVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMD2</accession>
    <name>A0A0F4JMD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947549.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34101">
        <property type="protein sequence ID" value="KJY34101"/>
        <property type="gene ID" value="VR44_12625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6591"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20142" checksum="5C8C12D8AE6C91BD" modified="2015-06-24" version="1">MRILLVGAGGTLGTAVHKALAARGHEVVGVGRSGGDLVADVTDPEQVARLYAQAGPLDAVAVAAGDAVFRPLSELTADDFAATLRGKVLSQIELVRQGAAHLAPTGSFTLISGILAEQPIVAGAAASAANGAVEAFVRAAAIELPPQRINVVSPTVLEESLPAYGPFFAGMEAVPAARAAAAYVRSVEGAQTGQVYRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMM6</accession>
    <name>A0A0F4JMM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947226.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35079">
        <property type="protein sequence ID" value="KJY35079"/>
        <property type="gene ID" value="VR44_10890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6058"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043777">
        <property type="entry name" value="DUF5719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18986">
        <property type="entry name" value="DUF5719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471189" evidence="2">
        <location>
            <begin position="34"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="496" mass="50112" checksum="508E317847869CC7" modified="2015-06-24" version="1">MKQRAPLTLAAVTAALAACCGLAFLTAPTAAPAADARRAAAARMPVERSVLVCPAPSSSDIADTTYTSLTPAAPAQAAGKGTARLAGTDGKTVLEPREPGKPVAATVSGAEAPGLTGVAQGVMAPGWTAQQTTKVAVGQARGLLGLACTAPGTDFWFPGVSTAKGRQDYVHLTNPDDTSAEVDIKLYGPDGLLKPKPGMPDQVTEVKPHSTTKVWLPPLAADAQLQDVTAHVTTRSGRVGAAVQIAEDGVGSDWLPASGGPAGSLVLPGIPADATSVRLVAFAPGEDDADLLLKLSGPNGSISPAGKEQLHVKAGMTATVDLADLTRGEAGSLLLAPADPKKPVPVVAALRVVRGTGAKQELAFIPASPPVGERATVTDNRLDDKATTLTLTASGGADAKVRVTASQGTEGGRPAVQELTLKAGTTRTVTPTPAPAGGKGPYALTVETLSGGPVYAARTLTLPQEGAPMFTVQTFADDRSRVSVPHAVEDPSVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMU2</accession>
    <name>A0A0F4JMU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pafA</name>
        <name evidence="4" type="ORF">VR44_10085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947079.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3221"/>
    <dbReference type="EnsemblBacteria" id="KJY35505">
        <property type="protein sequence ID" value="KJY35505"/>
        <property type="gene ID" value="VR44_10085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5616"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="453" mass="52157" checksum="24C5EEF344B41CA7" modified="2015-06-24" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDSLTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLICGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGQRKVRLASGREASALEIQREYYDKALDFAERRGIRTGVVEQVLELWGRTLDAIEAEDLDRIGREIDWVMKYQLIERYRAKHNMTMSNPRVAQIDLAYHDIHRRRGLYYLLERKGQAERVCNDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN80</accession>
    <name>A0A0F4JN80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947441.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34396">
        <property type="protein sequence ID" value="KJY34396"/>
        <property type="gene ID" value="VR44_12025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6490"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22470" checksum="F901310C8CD8C9AF" modified="2015-06-24" version="1">MEAELVRALEGLEHGSASVRLRAALEVGTAADPRCADALIARCAVEPEFFVRDMLTWALVRQPAEVTVPKLVEALGSESAQERSQALHTLSKIGDRRAWPAVTRGLLTDADDTVARSAWRAAVVLVPEGGAPDLAAVLATQLGRGGLETRLSLSRAFVALGEEVAPVLRTAAADPVPGVREHAIATERLLRDPDAGFEWALREAKRIMVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPE9</accession>
    <name>A0A0F4JPE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946745.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36247">
        <property type="protein sequence ID" value="KJY36247"/>
        <property type="gene ID" value="VR44_08325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4564"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="15912" checksum="48B27D845D5B1EC9" modified="2015-06-24" version="1">MNHDITRRETEVHHPVPLAPAIPAPTAAQQPLVVPDVQTIQLPDGRIITGYAINPAKAPEPVRERRTLNPVAVNIALGGIGFAAACGGLMLLTTFIAAVAALIQQLIILAAVIFGGFIATQVLGNHDRGNTGTVVNIRRAVFKRNHFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPF0</accession>
    <name>A0A0F4JPF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946993.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35628">
        <property type="protein sequence ID" value="KJY35628"/>
        <property type="gene ID" value="VR44_09630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5374"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="235"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="42008" checksum="DC98C79EA4E32D6B" modified="2015-06-24" version="1">MAHTTLVAPGVTTTRLPLLDVLRGAAILGTLMTNVWIFTSPGSEWSVAQGGLHVPDPLADPSAATSAEALFRFLADGKFLSLLTVLFGVGLAIQYDSAARRGERWPGRYPRRALFLFLEGTLHFVLLFAWDVLMGYAVTALLTAWLLARSERVRRVVMWVAGGLHLTLIGLVTLGGLLTPDPGPRTPDPEAVRLYAHGGWAEQIGFRLDHALALRVEPVFTFGLLVFLFLLGVRLYRAGAFAPTAAGRRIRARLAAWGLGLGLPLGAAAALGGDDFFLLGRYVLAPLIALGYAGLIGWALDRGAVPGARALASVGRTALSCYVGQNLLCVLLCYGIGFGLAERMAGSGPWWVMGLWAAVSLSLVAASGLWLRRFDRGPLEALQHRVLRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPJ9</accession>
    <name>A0A0F4JPJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000207">
        <property type="protein sequence ID" value="KJY35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35678">
        <property type="protein sequence ID" value="KJY35678"/>
        <property type="gene ID" value="VR44_09500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29284" checksum="3DC9F514B81A8D39" modified="2015-06-24" version="1" fragment="single">MAIDQDLTETQVIVVGAGPVGLLLAGELRLAGTDVVVLDTLTAPTSESRASTLHARTMEILDSRGLLDPLGEVPHDSTGHFGGIPLDLGLPGPYPGQWKVAQTRLEEVLGEWAADLGADIRRGHELTGLAETRDGVTATVRTEDGQLSLRAAYVVGCDGENSAVRRLGGFEFPGTDAERELLRADVAGIDIPNRRFERRDGGLVIAARRPDGVTRVMVHEFGARPRAGQPSFEEVADSWKRITGEDIGGGTPLWVNSFGDASRQASEYRRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPM5</accession>
    <name>A0A0F4JPM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000256">
        <property type="protein sequence ID" value="KJY34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947282.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000256.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34881">
        <property type="protein sequence ID" value="KJY34881"/>
        <property type="gene ID" value="VR44_11180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6242"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7723" checksum="288C36B5581843C6" modified="2015-06-24" version="1">MTDAVKGPASYFPSIEKKYGRPIAEWKDLIRTSSLTRHMELVNWLKAEHALGHGHANALVAHTLAEANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR62</accession>
    <name>A0A0F4JR62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_07075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946518.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4626"/>
    <dbReference type="EnsemblBacteria" id="KJY36852">
        <property type="protein sequence ID" value="KJY36852"/>
        <property type="gene ID" value="VR44_07075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3760"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21099" checksum="713E0770E9ED113E" modified="2015-06-24" version="1">MSPVRVLLADDEHLIRGALAALLGLEDDLAVVAEAASGPEALAMARAHRPDVAVLDLQMPGADGVSVATSLRSELPDCKVMIVTSHGRPGHLKRALAAGVRAFAPKTVSAQRLAELIRTVHAGGRYVDPELAADAISAGDSPLTAREAEVLELAADGAPIAEIAERASLSQGTVRNYLSSAATKLGAENRHTAVRLARARGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JST0</accession>
    <name>A0A0F4JST0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946507.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36894">
        <property type="protein sequence ID" value="KJY36894"/>
        <property type="gene ID" value="VR44_07015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3617"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470836" evidence="1">
        <location>
            <begin position="28"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="41"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="411" mass="42749" checksum="450D203695950D9B" modified="2015-06-24" version="1">MRSRQLIAVTAALAAGALTLTACGSRNDSGGSAGGDSGNTTVVIGVDAPLTGDLSALGLGIKNSADLAAKQANEKKYVKGVTFKIEALDDQAQASSGQQNATKLTADKNVLGVVGPLNSSVSEAMQKVFDDAKLTQISPANTSPSLTQGPKWAEGQKARTYKSYFRTATTDAIQGPYAAQYLFNKAGKKKVFIIDDKKTYGAGLAGTFKGEFTKLGGQVVGEGHIDPESKDFSAIVTQVKSSGADVVYYGGEYPAAGPLSKQIKASGTNIPLVGGDGMKDKKYVELAGPQAQGDLCTSVGAPVESLPSAKEFIDNYKKAGYKDDYSAYGGYSYDSAWAVIEAVKKVVDANNGKLPSDARAKVLEAVQGVNFDGVTGKVSFDEFGDATNKQLTVYKVDGDDFKTVESGTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSX8</accession>
    <name>A0A0F4JSX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946819.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36061">
        <property type="protein sequence ID" value="KJY36061"/>
        <property type="gene ID" value="VR44_08700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4983"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="30685" checksum="CF56373832E4DD1F" modified="2015-06-24" version="1">MAIGKAVYEAELLRLQTELIKLQEWVRAERARLIVVFEGRDAAGKGGTIKRVAEHLNPRVARIAALPKPTERERTQWYFQRYVEHLPAAGEIVLFDRSWYNRAGVEHVMGFCTPAEHQLFLRQCPIFERMLVEDGILLRKYWFSVSDAVQEERFRRRAEDPLRRWKLSPMDLESLTRWEAYSRAKDEMLVHTDTADAPWYVVDSDDKRSARLNMIAHLLSSVPYEDVALPPLLLPARPPSTGYERPPRELQTVVPDHAATLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT00</accession>
    <name>A0A0F4JT00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36898">
        <property type="protein sequence ID" value="KJY36898"/>
        <property type="gene ID" value="VR44_07030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="376" mass="40323" checksum="3DB2FEE8F39444C2" modified="2015-06-24" version="1" fragment="single">MAETASKKTEQTTAAGRPRLMLMDGHSLAYRAFFALPAENFTTATGQPTNAIYGFASMLANTLRDEAPTHFAVAFDVSRKTWRSTEFPEYKANRSKTPDEFKGQVELIGELLDAMKVPRFAVDGFEADDVIATLATQAEALGFEVLIVTGDRDSFQLVSEHTTVLYPTKGVSELTRFTPEKVVEKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKWINQFGSFAELVERAEEVKGKAGQNFRDHLEAVKLNRVLTEMVKDVELPKTPADLARAPYDRSAVTGVLDVLEIRNASLRERLLAVDPGADQEEAPAPAAGVELDGSVLGAGELAPWLAAHAGGPLGVSTVDSWGLGQGNVSEVALAAAGGAAAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU14</accession>
    <name>A0A0F4JU14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946101.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37857">
        <property type="protein sequence ID" value="KJY37857"/>
        <property type="gene ID" value="VR44_04845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1050"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="31976" checksum="95751401D80FD523" modified="2015-06-24" version="1">MELRHLRYFVSVVEEGGFTRAAARLHLAQPGLSAQIRQLEKELGQPLLDRSGRSVTLTEVGRAVLPYARAALAAAESVRQTADAYTGLLRGRVRLGLVSGATGHVFDIAALLADFHEAHPSVEVALTEDATERMQAALLAGELDIAVLGTAEEVPPPGVAFQTVIDVPLVAAVAPGDPVLGRVDGTSVPLAGLRDLPLICLPRGTGVRAALERGCAQAGFRPRVAFEAAAPHVLSRLAARGLGIAVLPAGEDGSPLDGQLRTLRIVRPEMRARIALAWQAGGPSSPAARVFLERLRDALPKPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV18</accession>
    <name>A0A0F4JV18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_04030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000074">
        <property type="protein sequence ID" value="KJY38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945955.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene739"/>
    <dbReference type="EnsemblBacteria" id="KJY38207">
        <property type="protein sequence ID" value="KJY38207"/>
        <property type="gene ID" value="VR44_04030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8711"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="30663" checksum="587038546A28FBB2" modified="2015-06-24" version="1">MPQHTSGSDRASVPPAARGGARSTEPSSLELLWRSYKDSGDERLREQLILHYSPLVKYVAGRVSVGLPPNVEQADFVSSGVFGLIDAIEKFDIERSIKFETYAITRIRGAMIDELRALDWIPRSVRQKARAVERAYATLEAHLRRTPTEGEVAGEMGIGVEELHTVFSQLSLANVVALEELLHVGGEGGDTLSLMDTLEDTAADDPVEVAEDRELRRLLARAINTLPEREKTVVTLYYYEGLTLAEIGNVLGVTESRVSQIHTKSVLQLRAKLADVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVH0</accession>
    <name>A0A0F4JVH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_05025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37748">
        <property type="protein sequence ID" value="KJY37748"/>
        <property type="gene ID" value="VR44_05025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1320"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470931" evidence="3">
        <location>
            <begin position="28"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="46513" checksum="82E6CF9A62D478B5" modified="2015-06-24" version="1">MPLVKTWQLIAGAAVAGLALSAVAVSAAGPWDSGQRKAERDRAASWSRTGGADHAAGSPPQAAPSAPGVLQGIAPRPADAPSAALTAALGPLLADPALGTVRGAAVVDAVTGAVLYESGSAEPMTPASTVKIATASAALAALGPEHRIRTTVTPGPGPGQIVLVGGGDPSLTAKKKSPAGSGGSLVALAADTAQALKAAGTDTVTLGYDDTLYSGPVRHPIGRNDNLAPVTALTADEARPDDSTAGPVERGEDPSKDTARSFAALLRDRGIKVNGEPAPAKPAPDARPLATTLSTPLAGLVERMLTNSDNDIAEALARQTALASGKPASFEGAEQAVTQRLGSLGVDLTGSRFADGSGLNRADKVSARLLTGLLAKAADPQHPELRPVLTGLPVAGFTGTLRTRNAGTSPAAGLLRAKTGTLTGVNSLAGTVVAPSGRLLAFAFLTANAADGSAAEKGLDKLAAAVATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVY4</accession>
    <name>A0A0F4JVY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37989">
        <property type="protein sequence ID" value="KJY37989"/>
        <property type="gene ID" value="VR44_04540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9418" checksum="5F810F4D1796E7EA" modified="2015-06-24" version="1">MSGDRNERRGGTWDVPTDDQSDAEPDVTGEFTIDYTPPAWYTQSPPPAPAAGVPGLPEGSGFEPHRQADAPAGGRGLALDDADRRAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW41</accession>
    <name>A0A0F4JW41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946378.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene62"/>
    <dbReference type="EnsemblBacteria" id="KJY37201">
        <property type="protein sequence ID" value="KJY37201"/>
        <property type="gene ID" value="VR44_06325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3019"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="45"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="44147" checksum="AB790E0FFC06EFC4" modified="2015-06-24" version="1">MTGDRYTVISADCHAGADLLDYKPYLAKRHHDEFDAWAATYVNPYEDLLADTADRNWNSARRLAELEADGIVAEVVFPNTIPPFFPKASLMAQPPSAAEYELRWAGLQAHNRWMADFCADAPGRRAGVAQILLNDVDAAVKEIRRTREAGLTGGVLLPGVPPGSTVPELYSDAYDPIWAVCDELDVPVNHHGGSASPPLGDEPAARAVFMVETTWFSHRALWHLIFGGAFRRHPGLKLVLTEQGSGWIPGVLQMLDYYHGRLVAASSTAESKFGAGLADSMGKGPSEVWRDNCFVGASFMRPHEVPLRERIGLDKIMWGSDYPHDEGTTPYSREGLRIAYAGLPREEVAAMVGGNAARVYGFDLTLLDALAAKHGPLVSEVAEPLTSVPPDATSPAFARGGSVRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW63</accession>
    <name>A0A0F4JW63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38074">
        <property type="protein sequence ID" value="KJY38074"/>
        <property type="gene ID" value="VR44_04375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.443"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="425" mass="46218" checksum="64D0B673001599FE" modified="2015-06-24" version="1">MRIHVLADSDTRWKWGAGLAVGLAPGSEVHAHMLRGRSTPTARQLAEVGITPSSITEATLAEFAAAPVLESADVIILGTVGGATHAALHALARRFAGAPYRPILMTGYVGVVYEKMADGLLLRAGADIVLANSPFDRRRFTEVYEPLGIPASSIVQTALPFLDERPYDPARTFAEHPYTVCFAVQPSVPADRNGRMYMLRRAISHARLRPGRDVLVKLRSKPGEATTHVEAFHYQVLAEQLDEPLPPNLHFVYGNMSQTLDRTDLLVTVSSTAALESMHRGMPTAILSDLGVREIHGNHYFTGSGCVTDWTAIDEGAAPIAHESWTVDQGIRSTDPFGELRNRIAELRGRPLPPITPYYTAASAPEYVGTLLRRRGLDPDGSPGPGAAAARSRGPMRRTSRRVLKVAYQFGVQRVAPKIQQWGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXQ3</accession>
    <name>A0A0F4JXQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_04995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000093">
        <property type="protein sequence ID" value="KJY37776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946133.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene177"/>
    <dbReference type="EnsemblBacteria" id="KJY37776">
        <property type="protein sequence ID" value="KJY37776"/>
        <property type="gene ID" value="VR44_04995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1314"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="485" mass="52037" checksum="A4D1FCD85DF9D803" modified="2015-06-24" version="1">MSIFTDLAHQYIDGEWLAGTGSWDIIDVNPYNGEKLAAITVATVEQVDRAYRAAERAQRDWAATSPYARRAVLERALRIAEERQKEIVEVMIDELGGTRPKAEYEVHLAMEFLREAIRLAVRPEGRILPSTVTGKENRVQRLPVGVVAVISPFNFPLLVTLKSVAPALALGNAVVIKPNQNAPVSGGGIIARIFEDAGLPAGLLNVLVTDIAEIGDAILTHPVPKVISFAGSDRTGRHVGAVAARHFKRTVLELSGNSALVVLDDADVDYAVDAAVFSRFVFQGQVCMAANRILVDASVAEEFTEKFTARVRALKTGDPREADTHIGPLINSFQADALTALVDRAVESGATALVRGATRGNLVEPTVLAGLPEDSPLLGQEIFGPVALLVVFDGEDEAVRLANATPYGLSGAVHTRDVERGVRFAQRVETGMIHVNDSTIGDEPLAAFGGEKDSGLGRLGGEATVEAFTTQKWISIQHGRTTFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY49</accession>
    <name>A0A0F4JY49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945537.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000076_gene7451"/>
    <dbReference type="EnsemblBacteria" id="KJY39307">
        <property type="protein sequence ID" value="KJY39307"/>
        <property type="gene ID" value="VR44_01740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5750"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18178" checksum="4F789283B411F7AE" modified="2015-06-24" version="1">MSEVRETLTYEAFGSAVRELAQTIAADGYEPDIILSIARGGVFVAGGLAYALDCKNIHLVNVEFYTGVGTTLEMPVMLAPVPEAIDFTDKKVLIADDVADTGKTLKLVHDFCLGHVAEVRSAVIYEKSHSLVNCEYVWKKTDDWIEFPWSTEPPVVKREGQILDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYZ6</accession>
    <name>A0A0F4JYZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_00950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39612">
        <property type="protein sequence ID" value="KJY39612"/>
        <property type="gene ID" value="VR44_00950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2903"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="339"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="760" mass="80381" checksum="008C0DBA778BF165" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZQ4</accession>
    <name>A0A0F4JZQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="11" type="ORF">VR44_01820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945549.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39319">
        <property type="protein sequence ID" value="KJY39319"/>
        <property type="gene ID" value="VR44_01820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5768"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="9">
        <location>
            <begin position="447"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="10">
        <location>
            <begin position="884"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="983" mass="106043" checksum="BBF5BDE4F9325FA3" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Z2</accession>
    <name>A0A0F4K0Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39598">
        <property type="protein sequence ID" value="KJY39598"/>
        <property type="gene ID" value="VR44_01225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2961"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471026" evidence="2">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17505" checksum="46DB922951CEC1A5" modified="2015-06-24" version="1">MLAAALSLTAALAISGCSSSSSDSGSSSSASAGTKAEESAKPKMTVSGAYMPEPVNDKMAGAFMVIKNDSKTADKLIGVTSPLSDDLQVHETKDQKMQQVQSMDVPAGGDLNLERGGSHIMFMGLKNKPNVGDKVTIELRFEKADPVKVELDVKERTYNPQNSTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K109</accession>
    <name>A0A0F4K109_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">VR44_00985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005315025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4748"/>
    <dbReference type="EnsemblBacteria" id="KJY39618">
        <property type="protein sequence ID" value="KJY39618"/>
        <property type="gene ID" value="VR44_00985"/>
    </dbReference>
    <dbReference type="GeneID" id="61488328"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2910"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8962" checksum="D6474BD65791FA04" modified="2015-06-24" version="1">MAKPPVRKPKKKVCAFCKDKTAYVDYKDTNMLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K122</accession>
    <name>A0A0F4K122_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="13" type="ORF">VR44_01075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945412.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4729"/>
    <dbReference type="EnsemblBacteria" id="KJY39633">
        <property type="protein sequence ID" value="KJY39633"/>
        <property type="gene ID" value="VR44_01075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2928"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiC-associated" evidence="12">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="599" mass="66353" checksum="AF7621824125C8F5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K4H4</accession>
    <name>A0A0F4K4H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000001">
        <property type="protein sequence ID" value="KJY40086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40086">
        <property type="protein sequence ID" value="KJY40086"/>
        <property type="gene ID" value="VR44_00005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY40086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13190" checksum="BB7447E57AEC9B9B" modified="2015-06-24" version="1" fragment="single">AEPAEPASGAPRPARRTRSAADGSASQAAPPAEAGPDTAAPESEAPRPARRNRSASDGSVSQAPAPEPEAPRRPAPRSPDAPWHNPKPAFDEPEPGPAPEAEPRPQPEATPEARPEAGPGTDHDTTGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I564</accession>
    <name>A0A0F4I564_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_40700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001823">
        <property type="protein sequence ID" value="KJY15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15896">
        <property type="protein sequence ID" value="KJY15896"/>
        <property type="gene ID" value="VR44_40700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="8984" checksum="D22835A1258DF03E" modified="2015-06-24" version="1" fragment="single">LVISGITGIRVGRIIDHHGPRMVMTAGSATGTTGLVVIALAPNLPVFFAGWILAGLAMSATFYQPAFAALTRWWAPDHVRALTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8I2</accession>
    <name>A0A0F4I8I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001647">
        <property type="protein sequence ID" value="KJY17788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17788">
        <property type="protein sequence ID" value="KJY17788"/>
        <property type="gene ID" value="VR44_39830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6267"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="475" mass="49299" checksum="5AD9782CA72E4BCC" modified="2015-06-24" version="1" fragment="single">EHDESTALVPSLRRGRDEAVCAVTALGRLLVAGAVADRTAFFAGSRVSRVDLPTYAFQHRTFWVSTSVGSVGDVASAGVAAAGHPLLGAAVTLPSASGMLFTGRLSLHTHPWLRDHQVHGQVVFPGAAMVELAVRAGEEVGHGLLDDLTIEAPLVLPPSGGVQLRLMLAEPDGHGRRALSLFSRPEDAGSDEPWVRHAAGAVLRTPDVPRGAGAPLAAWPPAGATALDTDCLYEVLAALGFGYGPAFQGLRAAWQLGEEVYAEVALPEAATADAGRFGLHPALLDAALHGIGLGSFVPEEPGRARLPFNWSGVSLHASGATALRVRIAPAGPDAVALTLADRTGAPVAAVESLALRAVTAEQLEDGSLRDALFRLEWAEAAAVDGGEPGSWAWLGEEGENVPAYVVTRTPGGEVHSAVAEALALVRAWAADERYAASRLVFTADVQDVATAAVWGLVRSAQTEHPGRFALVEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBK2</accession>
    <name>A0A0F4IBK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_39360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001580">
        <property type="protein sequence ID" value="KJY18868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952496.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001580.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18868">
        <property type="protein sequence ID" value="KJY18868"/>
        <property type="gene ID" value="VR44_39360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5674"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469336" evidence="5">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY18868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="7408" checksum="19DEE6C13BC84F00" modified="2015-06-24" version="1">MNSAAKKAAVALASAGLAVAGAAGAASADAQAEGAAVGSPGVLSGNLVQVPVHVPINVCGNSVNLVGALNPAFGNVCVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDF5</accession>
    <name>A0A0F4IDF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001549">
        <property type="protein sequence ID" value="KJY19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19483">
        <property type="protein sequence ID" value="KJY19483"/>
        <property type="gene ID" value="VR44_39090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13229" checksum="0DCAAC0220DB1AFA" modified="2015-06-24" version="1" fragment="single">NLRLTGPSAAFMVAARLDALRGAGHLVRIADRVELGARLPEAQLEEVCAGLARDCAGLGAVFVPAIPTAAFDPAPWLGVLVAAHSREVLDAAEALVRERARAVGEDFAVGERGQPSEPDGGAAGLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDH2</accession>
    <name>A0A0F4IDH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001591">
        <property type="protein sequence ID" value="KJY18716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18716">
        <property type="protein sequence ID" value="KJY18716"/>
        <property type="gene ID" value="VR44_39470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="648" mass="67365" checksum="3D5747BE493C9097" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IER2</accession>
    <name>A0A0F4IER2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001526">
        <property type="protein sequence ID" value="KJY19943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19943">
        <property type="protein sequence ID" value="KJY19943"/>
        <property type="gene ID" value="VR44_38895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="364" mass="40296" checksum="4473D64A3AD7BDEE" modified="2015-06-24" version="1" fragment="single">MDPRGPAPAVDWPARPDLSLALNRMGTFDWDLDSGRMHLDATALEVLGLPAERFDGTSDGLRARILPDDAARLEHRVRQALRDGRSHYGAYFRALRDDGGTTWTHLQGHVLRDRTGRPYRIIGILRDADQDPAEPGAAGERDEGRRRMTGVVERTAAILAHARTVNDVTDVLKDPEALGHLGAVSVMLGIVDGGRIHLVAEGQLGAYVPEIEYTRIDARLPMSEAVRTLQAVYLSSREEFRRRYPDLWPYIEPLSVRSGVYLPLIAQGRPVGALGLLYTRDGDFTAEERNLLVALGSGIAQSLQRAILFEQEHDLAEGLQRAMLPRRIPEVAGARIAVRYRAARIGRDIGGDWYDVIPLGEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHS2</accession>
    <name>A0A0F4IHS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001464">
        <property type="protein sequence ID" value="KJY21239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000033_gene6731"/>
    <dbReference type="EnsemblBacteria" id="KJY21239">
        <property type="protein sequence ID" value="KJY21239"/>
        <property type="gene ID" value="VR44_38350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="158"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="314"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY21239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="458" mass="50095" checksum="879E578E465EB132" modified="2015-06-24" version="1" fragment="single">MRDPHHDLDDRIARFATIWGRAIFPVTATSLTRPEFEQHLVPLARTLTEALHARPFDASAAQGVGAELVAVHCTDPEALAGTLGVIESYLVLYCGPDSAAGDGSESTEEYRSRCARLQHGIAAGFARALRERTLREQEAIARSALTARIDAQQALHASEERFRAVFEGAAVGIGIADLEGNILEVNDTLLKMFGGLEGHVRSRNVSEWGHPDDTPHVWKMYGELVRGEREHYRVEKPYYRHDGTVLWTNLTVSLLRDADGRPQYQLALMEDTTERRLLNLRLRYEATHDALTGLPNRTLFFERLEKALNAAPGSRFGLCYLDLDGFKAVNDSLGHSAGDRLLVEVADRLQSCATGPGEVVARLGGDEFVALTTGPGAQTEEKVTDLAVRILTALSTPIRLEGRELSVRGSIGIVEGASGERTPAEVLRSADITMYRAKAAGGNRFEFADAEADARAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INW0</accession>
    <name>A0A0F4INW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001381">
        <property type="protein sequence ID" value="KJY23715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23715">
        <property type="protein sequence ID" value="KJY23715"/>
        <property type="gene ID" value="VR44_37485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4916"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9207" checksum="E20E516BECCEB888" modified="2015-06-24" version="1" fragment="single">SGAAAWDAAKRKAFANDLTRPQLLAVSAASNRSKGDQSPDLWQPSDKSSWCQYGRAWTTVKSHYGLTVTDAERAMLTTMIDTCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPQ3</accession>
    <name>A0A0F4IPQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001313">
        <property type="protein sequence ID" value="KJY24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951979.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001313.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3584"/>
    <dbReference type="EnsemblBacteria" id="KJY24005">
        <property type="protein sequence ID" value="KJY24005"/>
        <property type="gene ID" value="VR44_36600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4628"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="30878" checksum="E603F3F0E7BCB023" modified="2015-06-24" version="1">MYDPVQLRTFLTVAQTLSFTQAAGRLGVRQSTVSQHVRRLEEATGRPLFARDTHSVALTEDGEALLGFARTILEAHERAAAFFTGTRLRGRLRFGASEDFVLTRLPEILEGFRHEHPEVDLELSVELSGILHERLDEGRLDLVLAKRRGPGDERGRLVWRDRMVWIGAEGLRLDPERPVPLIVFPPPGITRARALEVLEREGRAWRIACTSGSLSGLIAAARAGLGVMAHTRGLIPPGLVRVGGLPELGPVEFALLQGRRPTPAAEALAAAVLAGGDRLSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ81</accession>
    <name>A0A0F4IQ81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_36185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001280">
        <property type="protein sequence ID" value="KJY24157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951901.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001280.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5267"/>
    <dbReference type="EnsemblBacteria" id="KJY24157">
        <property type="protein sequence ID" value="KJY24157"/>
        <property type="gene ID" value="VR44_36185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4480"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="87"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="271"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="465" mass="49353" checksum="4BDFABA884C1E328" modified="2015-06-24" version="1" fragment="single">MTSSSSARPSRRPSRGRGAAQGRPKAGAGRQKPAPVARPQEFTMPEPQTPALPPVAAFEDMDMPEALLKTLAAQGVTEPFPIQAATLPNSLAGRDLLGRGRTGSGKTLAFGLALLARTSGRRAQPKAPLALVLVPTRELAQQVTDALTPYATAVNLRVATVVGGMSINRQAGALRRGAEVLVATPGRLKDLIDRGDADLSQVSITVLDEADQMTDMGFMPQVTALLKQVEPGGQTMLFSATLDKNVDKLVKMFLTDPVGHSVDPSAGAVTTMEHHVLYVMDETDKKAVATRIAARDGRVIMFVDTKRGVDRMVKKLLAEGVRASGLHGGRSQPQRNRTLDWFKTGEVTALIATNVAARGIHIDDLDLVVNVDPPTDHKDYLHRGGRTARAGESGSVVTLVLPDQKRDMTRLMSDAGISPRTAQIKSSDEELAQLTGAREPSGIPVVLEVPQPPAQPKARSGSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRE9</accession>
    <name>A0A0F4IRE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001203">
        <property type="protein sequence ID" value="KJY24567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951673.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001203.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24567">
        <property type="protein sequence ID" value="KJY24567"/>
        <property type="gene ID" value="VR44_34965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4072"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="30660" checksum="ED49F6F0DDD14A9A" modified="2015-06-24" version="1">MCRWLAYSGTPVLLDTILYKPAHSLIDQSLHARMGVETTNGDGFGIGWYTQTSGIDTPAVMRDVGPAWNNRNLREIAQHVTSPLFFAHIRASTGTAVQQTNCHPFRHGRWLWMHNGSIAGFHEMRRELCVAVEPSLFPGMEGTTDSEVMFYLALTLGLEEDPPGAVARMVGLVERTGRAHGVENPMQMTVAVTDGESLWAFRYASGGGARSLYYSTRVDSLRALHPDVSFLQELSDETRLVVSEPLGDLPGAWNEVPEHSYGVVRPGDDHLRPFVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRF3</accession>
    <name>A0A0F4IRF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001196">
        <property type="protein sequence ID" value="KJY24600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24600">
        <property type="protein sequence ID" value="KJY24600"/>
        <property type="gene ID" value="VR44_34870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4050"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="14826" checksum="454F2BC5E669A380" modified="2015-06-24" version="1" fragment="single">MARSGAEGRGVLEGAFALMEVLAHDDEVGLTRLASDAALPKATAHRLLGQLVALGAVQSHEGRYRLGPRTFRLGQAWHPARALRAAAAQPLRELAAAGGGVSLSLSVPEAGHIIVVGGMRGEVDEVFPLRSGVVLPPGSAAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRV6</accession>
    <name>A0A0F4IRV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001234">
        <property type="protein sequence ID" value="KJY24399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24399">
        <property type="protein sequence ID" value="KJY24399"/>
        <property type="gene ID" value="VR44_35515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469739" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12084" checksum="13BFCFC78DAD09C2" modified="2015-06-24" version="1">MPAVPVPVPAAVPVPVRAAPAVPAVRVVPAAASPAVRPVRARVRPVAASAARVRVAAASAAARPVPVAAVVPASVAVPAARVPVVARRVRSAVPAGPPVAVASRSVRGARSTRPCRPRPWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT60</accession>
    <name>A0A0F4IT60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001338">
        <property type="protein sequence ID" value="KJY23891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952048.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001338.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23891">
        <property type="protein sequence ID" value="KJY23891"/>
        <property type="gene ID" value="VR44_36945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4772"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="13114" checksum="12C6A340794B87EB" modified="2015-06-24" version="1">MTAQHTEADGPLIPQPAMTREALRDAVRRLDMRSLAEFDTECHEAFDRAAETGAINPLRFFLIKWATHVAIQRWPARAGALAEAQRLAGDPTVEDKVFRAAMETSSRILAEAQQEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITB7</accession>
    <name>A0A0F4ITB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">ureC</name>
        <name evidence="13" type="ORF">VR44_34495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001177">
        <property type="protein sequence ID" value="KJY24718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6923"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="KJY24718">
        <property type="protein sequence ID" value="KJY24718"/>
        <property type="gene ID" value="VR44_34495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3882"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="136"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY24718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="573" mass="60472" checksum="A0EE83830905C053" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITL8</accession>
    <name>A0A0F4ITL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_32705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001087">
        <property type="protein sequence ID" value="KJY25357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951259.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001087.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4310"/>
    <dbReference type="EnsemblBacteria" id="KJY25357">
        <property type="protein sequence ID" value="KJY25357"/>
        <property type="gene ID" value="VR44_32705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3354"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469816" description="Phospholipase C" evidence="7">
        <location>
            <begin position="30"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="8">
        <location>
            <begin position="496"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="8">
        <location>
            <begin position="594"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="686" mass="73876" checksum="1CC3C5D4205F4583" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUI7</accession>
    <name>A0A0F4IUI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_31860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001037">
        <property type="protein sequence ID" value="KJY25672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951103.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25672">
        <property type="protein sequence ID" value="KJY25672"/>
        <property type="gene ID" value="VR44_31860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="11">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY25672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1144" mass="122720" checksum="C612A3D06B13DFFD" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV57</accession>
    <name>A0A0F4IV57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951244.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25368">
        <property type="protein sequence ID" value="KJY25368"/>
        <property type="gene ID" value="VR44_32625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3333"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470438" evidence="1">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15176" checksum="F57982CF9A6F902F" modified="2015-06-24" version="1">MRVPRILALASMTVALTVALAGVAPAQARPAPTGTGSAVTAPRDQIQCPRGFVCIYPEIGFEGQPYVKRATDGSVRHLPDYIRGKGSSVINNSSRTARVYQKDNYFGRHVCVGADGGAIGDLRSYQLNDTTHSLKNNTTPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWG9</accession>
    <name>A0A0F4IWG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001134">
        <property type="protein sequence ID" value="KJY25011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25011">
        <property type="protein sequence ID" value="KJY25011"/>
        <property type="gene ID" value="VR44_33695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3648"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="2">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11932" checksum="49952785EA235CCC" modified="2015-06-24" version="1" fragment="single">MTARRALARYHRRRDFSRTAEPEGRLAEASGERPSYVVQIHDASSMHFDFRLEADGVLKSFAVPKGPSNDPHDKRFATPTEDHPLEYRDFEGTIPEGEYGGGTVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWN8</accession>
    <name>A0A0F4IWN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001014">
        <property type="protein sequence ID" value="KJY25888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25888">
        <property type="protein sequence ID" value="KJY25888"/>
        <property type="gene ID" value="VR44_31365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2763"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="7974" checksum="05E3C856EC825784" modified="2015-06-24" version="1" fragment="single">CTFLYVGALARAGRLEAARYAFDKMLTYANHVGLFAEEIGPTGEQLGNFPQAFTHLALIAAALSLDEELDRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX15</accession>
    <name>A0A0F4IX15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000926">
        <property type="protein sequence ID" value="KJY26552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950720.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000926.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7412"/>
    <dbReference type="EnsemblBacteria" id="KJY26552">
        <property type="protein sequence ID" value="KJY26552"/>
        <property type="gene ID" value="VR44_29765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2333"/>
    <dbReference type="eggNOG" id="ENOG5032SVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9985" checksum="ECC156C683FC3DE7" modified="2015-06-24" version="1">MTDGGQAGETGEAADQTAAARLTAAEAAVLAYEGRSWPGPGAKERAIREGLGLSPVRYYQLLNALMDDPRALAHAPGTVNRLRRIREAQRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX94</accession>
    <name>A0A0F4IX94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001095">
        <property type="protein sequence ID" value="KJY25301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25301">
        <property type="protein sequence ID" value="KJY25301"/>
        <property type="gene ID" value="VR44_32865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469917" evidence="1">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="30938" checksum="7897D533B36490A8" modified="2015-06-24" version="1">MATVAAAALAALLAGPATPASASVSCFGSGGNTSILFYRAGSGSAVTGTLSAGHWESSGEFHLPRGYTHAAASHDSLLLYNKITGAGEVGTFTFGEYARTRTIGDLPKGWTQVEASGDSVIFYDIQTGHAVTGTLQNGKYQQVRTYDNFKKGWAAMASSCDTLTAEARPGSATFSWDASEHGTLRGGIYGRTGSLFLEEEEHLGQLTATRDSVLSWAKSGGKLALRAGTATNGWVFDLDEVGTSPLWEKVGRTADSLIFYNSDGTASTSTLVDGHYKSVGPLDEISPGWTLIEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXD0</accession>
    <name>A0A0F4IXD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001090">
        <property type="protein sequence ID" value="KJY25336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951270.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001090.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25336">
        <property type="protein sequence ID" value="KJY25336"/>
        <property type="gene ID" value="VR44_32775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3367"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469908" evidence="1">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="10715" checksum="AE9C2F289319A9C3" modified="2015-06-24" version="1">MRANLITPAAAALALGALLSAAAGAAQAAGPGFQYVGQDDRVHGVTSTKGCVEAAGGGGRAVTNQTRLTASLYRDPHCKGPVVAVMRPEAVSPVRPSFASVRFSLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY17</accession>
    <name>A0A0F4IY17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000948">
        <property type="protein sequence ID" value="KJY26368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950799.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000948.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26368">
        <property type="protein sequence ID" value="KJY26368"/>
        <property type="gene ID" value="VR44_30210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2449"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14723" checksum="3E9D84D83BB75734" modified="2015-06-24" version="1">MTRRVHEVMTGNPVTVEKLTSLAEAARVMRDADIGDVLVVDEGRLRGILTDRDLVVRAMADNRDPAETTVQAVCTTDPVTVGPDDGVDEAIALMRRKALRRLPVVSGNGELVGVVSLGDLVVEQDPGSALAAIAAAGHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY57</accession>
    <name>A0A0F4IY57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000882">
        <property type="protein sequence ID" value="KJY26955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950535.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000882.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7158"/>
    <dbReference type="EnsemblBacteria" id="KJY26955">
        <property type="protein sequence ID" value="KJY26955"/>
        <property type="gene ID" value="VR44_28775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2087"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="566" mass="63154" checksum="9AEF08818423BEDA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYB3</accession>
    <name>A0A0F4IYB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_28675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950520.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26987">
        <property type="protein sequence ID" value="KJY26987"/>
        <property type="gene ID" value="VR44_28675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2066"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7562" checksum="2E79AE98BEA2DE21" modified="2015-06-24" version="1">MSALTRPRDGRLIGGVCAGLAKRFGMKARTMRLIFVLSCLLPGPQFLVYLALWLLIPNEKSGVGAASTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ58</accession>
    <name>A0A0F4IZ58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000849">
        <property type="protein sequence ID" value="KJY27315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950381.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000849.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27315">
        <property type="protein sequence ID" value="KJY27315"/>
        <property type="gene ID" value="VR44_27910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1831"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="14201" checksum="5CAD1BCBD34FF00A" modified="2015-06-24" version="1">MASLNVGNLGEYLREQRRQAQLSLRQLADAAGVSNPYLSQIERGLRKPSADILQQLAKALRISAETLYVQAGILDERDRDEVETRAVILSDPSINERQKQVLLQIYDAFRKEKAADEPAADGAVPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZB4</accession>
    <name>A0A0F4IZB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950512.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5479"/>
    <dbReference type="EnsemblBacteria" id="KJY26979">
        <property type="protein sequence ID" value="KJY26979"/>
        <property type="gene ID" value="VR44_28635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2056"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="31861" checksum="112A8A8D27621453" modified="2015-06-24" version="1" fragment="single">GLAQFVAVARHEHVTRAAQELGVPQSTLSRAMVRLEQDLGVSLFARKGRTVALTTAGRTFLASAEEALAGIARAAGSVQQDADPGVGKVAFGFLHTLGPETVPGLIRAFRADHPRVRFSLVQNYGEAMLEKLRAGELDLCLTSPVPDAPDLVGRRLDEQRLRLVVPDDHRLAVRKRIRLAEAAEETFVTLEPGYGLRRITDNLCAEAGFTPKVAFEGEEAETLRGLVAAGLGVALLPPPLVPRPGVVELTVTAPRAVREIGVAWLDGHPDTPPVAAFKRFLLSRRGRLIPELEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZW6</accession>
    <name>A0A0F4IZW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000970">
        <property type="protein sequence ID" value="KJY26221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26221">
        <property type="protein sequence ID" value="KJY26221"/>
        <property type="gene ID" value="VR44_30650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2584"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7415" checksum="80EB8E9D86BCEBFE" modified="2015-06-24" version="1" fragment="single">MNSSGEGSAWTPGRPRPRVGLLGTGPWARRTHAPALAAHAGSDFTGVWGRRPEAAAELAGAYGVKVYEDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZZ0</accession>
    <name>A0A0F4IZZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000857">
        <property type="protein sequence ID" value="KJY27219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950422.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000857.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3087"/>
    <dbReference type="EnsemblBacteria" id="KJY27219">
        <property type="protein sequence ID" value="KJY27219"/>
        <property type="gene ID" value="VR44_28135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1871"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="33395" checksum="18769873632259CE" modified="2015-06-24" version="1">MIELEGLTKRFGAKTAVDDLSFQVKPGAVTGFLGPNGAGKSTTMRMMLDLDNPTSGTVRIEGKHYRDLKEPLKHIGALLDAKAMHGGRSAYNNLLCLAQSNRIPKSRVDEVLDLVGLTPVARKKSKGFSLGMGQRLGIAAALLGDPEILMFDEPVNGLDPEGILWIRNLMKGLASEGRTIFVSSHLMSEMALTADHLVVIGQGKLLADLSMADFIHQNSRSYVRLRSPQQERLKDVLHGAGIHAVSVPATGTLEIDGVPSERIGELAAEHRIVLHELSPQRASLEEAFMRMTADSVEYHAHAPRQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZZ6</accession>
    <name>A0A0F4IZZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000876">
        <property type="protein sequence ID" value="KJY27043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950491.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000876.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27043">
        <property type="protein sequence ID" value="KJY27043"/>
        <property type="gene ID" value="VR44_28520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2032"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="42094" checksum="79C3F8845F40EBC5" modified="2015-06-24" version="1">MTTAPPPVRTGADRRRAPLVLRNRAFGAVWLGQVLTQAAVRMFQVGTAWWIVAYAVDDARGLASGLFMAACTLPAVALAPVVASAVARFAHRSVLRTAAALAGAASGALALWASGGGPPLAAVYATGLALAACQAFFDPCLTTSVPELVDDADIETATGFELSTQSLAGLGGALLGALTVDRAGVAGLASGCAAAYLGAALLVASARFRTVGPGAGADAPAPSRPRPLRRILAELPYVRRILVCFTAANLFTAAVFVVIPLYTRSVLAGGGGTVALLEASLGTGTLVGAFTGARMPGRPTVAGAYGLGLMALALALPGLLTHRAAVMGCLVVAGWCAGAVSVRFVALFQRLVPAADKPGFFAVMQAVLGASVPVASLAFGLAGDFVSPQVLCLVQGVGLVPAACALALLESPAAEPAGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0C4</accession>
    <name>A0A0F4J0C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000804">
        <property type="protein sequence ID" value="KJY27720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27720">
        <property type="protein sequence ID" value="KJY27720"/>
        <property type="gene ID" value="VR44_26920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17586" checksum="5EF313F59B9786A5" modified="2015-06-24" version="1" fragment="single">YQGARYALDEAELALLGVLRQDGRAGYPELARASGLSESTARRRLERLRERGAVYFDVEIIPEHLGFETDTSLLLTVPPARLAEVGAALGSHPEVPFAAAITGAANLLAVVLCRDTDALYTYLTERIGAVPGVGQVEVIPNLRTIKRAGMLVEDGRLVDPPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0E0</accession>
    <name>A0A0F4J0E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000860">
        <property type="protein sequence ID" value="KJY27193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27193">
        <property type="protein sequence ID" value="KJY27193"/>
        <property type="gene ID" value="VR44_28210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1884"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="9571" checksum="D97E7A246916F0CD" modified="2015-06-24" version="1">MADRSYLSLWSRGSVLSIGSVGSVLSVGSVGSVLSVGSLGSALSVGSAASWLSAGSAFSARSAFSLFSYRSRGGLAVAGIGAVTAAALATGLLRTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0M5</accession>
    <name>A0A0F4J0M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27835">
        <property type="protein sequence ID" value="KJY27835"/>
        <property type="gene ID" value="VR44_26695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13538" checksum="9431E9D2D65F7741" modified="2015-06-24" version="1" fragment="single">MLRLENLVRTHGSGATEVHALRGIDLAVHPGELVAVMGPSGSGKSTLLTLAGGLDTPTSGRIVVEGVDITTAGRRKLAALRRRSIGYVFQDYNLIPALTAAENVALPLELDGTSARRARTAALAALEEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1C6</accession>
    <name>A0A0F4J1C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HutD-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000908">
        <property type="protein sequence ID" value="KJY26726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950640.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000908.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26726">
        <property type="protein sequence ID" value="KJY26726"/>
        <property type="gene ID" value="VR44_29340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2232"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943">
        <property type="entry name" value="PTHR37943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="20811" checksum="AF9AB0506AA9F970" modified="2015-06-24" version="1">MPGPAAIRILRAADRAAVPWKNGGGVTREIASRPGGAGTEDFAWRVSLAEVAADGPFSEFPGVDRILTLAEGAGMDLTVAGRHRRVDERYAPCDFPGDEPTGCRLLDGPVVNFNVMYRRGAVEARTAVIRGELSLAVPPDTALLVVALDGPARIGHPDGADELGPYDAALLEAPLTPYRVRTAGRTAVVGLRTITACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1D1</accession>
    <name>A0A0F4J1D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_29345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000908">
        <property type="protein sequence ID" value="KJY26731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26731">
        <property type="protein sequence ID" value="KJY26731"/>
        <property type="gene ID" value="VR44_29345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2233"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470477" evidence="4">
        <location>
            <begin position="50"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26781" checksum="59123D61817FB64C" modified="2015-06-24" version="1">MLSNTRTSNTEPVREEAAPSRRALLRTAVAGTAAAGSVLALGSSFPASAATSGAAVRPTTPQQALRELEAGNRRWRTHRQEHPHESPATRLRLTTAQHPFAIVLGCVDSRVPPELVFDQGLGDLLTVRSAGEVLDEAVLGSIAYGVLELAVPLVLVLGHQSCGAVKAAVHAEETGERLPAHIQYLADQIRPSIDHAQQGEARVSATIDANARRTRDRLAAEPDLARAISAGKLAVAAARYDLRDQRVRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1J2</accession>
    <name>A0A0F4J1J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Voltage-gated sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_27215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000815">
        <property type="protein sequence ID" value="KJY27603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27603">
        <property type="protein sequence ID" value="KJY27603"/>
        <property type="gene ID" value="VR44_27215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1632"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="6">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="28338" checksum="63F4EB5FC43B5233" modified="2015-06-24" version="1" fragment="single">MTDTMPAGTGRGRLAGHCRGITEAPSFGMGVFVVILINAGLMGAETYSGLAASQGRILQLAENGCLVLFTLEMVLRLGSYADRPKAFFRDPWNIFDLLIVTSAFLPFLRSNTTVLRLLRLARVLRTARFLPHLRILLLAVGRSLPGTASFLFVGALVVYVYAMVGWVCFAHSDPQHYGSIGRAALTLFLLTTLDGLTDAVRAGLEISRFSIVYYASYALLASFVLVNVLIGVVLNSLDEAREMEEADARARERAGRDMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J288</accession>
    <name>A0A0F4J288_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950494.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27026">
        <property type="protein sequence ID" value="KJY27026"/>
        <property type="gene ID" value="VR44_28540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2037"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="35556" checksum="DBC12FA23FDA35CD" modified="2015-06-24" version="1">MPQPGLREVEHEITVSAPAAAVYRLIAEVQNWPRIFPPTIYVDHIPQGGNEERIRIWATANGEPKNWTSRRTLDPEKLTITFRQEVPAPPVAAMGGTWIIEPLPEGESRVRLLHDYRAEDDDLAKLEWIDKAVDRNSRSELAALKTNVERAHATEDLTFSFEDTVRVEGSAKDVYDFVNEADLWPERLPHVAVVRLTEDTPGLQELEMDTRAKDGSVHTTKSYRVTFPHERIAYKQTTLPALMSLHTGYWTFAEDGEGGVSASSQHTVTINTENIARVLGPEATVEDAKAYIHTALSTNSTATLNHAKAFAEQRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2H5</accession>
    <name>A0A0F4J2H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000766">
        <property type="protein sequence ID" value="KJY28069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950055.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000766.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28069">
        <property type="protein sequence ID" value="KJY28069"/>
        <property type="gene ID" value="VR44_26145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1385"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14270" checksum="8FA9C4B195F5538C" modified="2015-06-24" version="1">MADIRRTVSSGSPLEPRIGFSRAVRLGRHVAVAGTAPIGDDGSTVGPGDVHAQTVRCLDIAQRALEEAGASLEHTVRTRIMLTDITRWEEAAQAHGERFAGIRPAATFVEVSRFIDPAWLVEVELDAILDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J413</accession>
    <name>A0A0F4J413_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000684">
        <property type="protein sequence ID" value="KJY29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949646.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000684.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29010">
        <property type="protein sequence ID" value="KJY29010"/>
        <property type="gene ID" value="VR44_23950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.765"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_8_N" evidence="4">
        <location>
            <begin position="44"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="2">
        <location>
            <begin position="410"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="3">
        <location>
            <begin position="685"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="797" mass="83202" checksum="A16F50C67357144A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4J6</accession>
    <name>A0A0F4J4J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_24910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949823.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28638">
        <property type="protein sequence ID" value="KJY28638"/>
        <property type="gene ID" value="VR44_24910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.982"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470138" description="Histidine kinase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="257"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="50242" checksum="6765071BD812822F" modified="2015-06-24" version="1">MRARLLPLLVVLMAGVLLALGLPLAVSLAAAQQQKVVVDRIDDSARFAALAQFVIDAEGSGATGADERRDTLQLELARYHELYGIRVGIFYRDDNAMVRAPGWWQLPDSDEARRSFEEALAGRRSHDPGQVWPWQVNGKLLVVSPVVLDGDVVAVVATESPTDQMRARILHGWLLIAAGLAAAMLAAFGAALRLTGWVLKPVRTLDAAAHGIATGRMNSRVAAASGPPELRRLARSFNEMADNVEEVLEQQRAFVADASHQLRNPLAALLLRIELLALELPEGNEEIASVRTEGKRLAQVLDDLLDLALAEHASAEIKLTDIAALASERVASWRPYAEEKGVRLSETGRSAVTGWADPIALSSALDAVIDNALKFTPAGEEVEVSVTAEGSSALVVVADRGPGLTEEELLRVGDRFWRSGRHQNVKGSGLGLSISRALLATGGGTLSYAKNQPHGLRVTVAVPRTGPDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5R0</accession>
    <name>A0A0F4J5R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_22250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000623">
        <property type="protein sequence ID" value="KJY29697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812873.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene484"/>
    <dbReference type="EnsemblBacteria" id="KJY29697">
        <property type="protein sequence ID" value="KJY29697"/>
        <property type="gene ID" value="VR44_22250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.336"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="24983" checksum="EDF9582A5FC939C6" modified="2015-06-24" version="1">MTRVLLAEDDASISEPLARALRREGYEVEVREDGPTALEAGLQGGVDLVVLDLGLPGMDGLEVARRLRAEGHGFPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGANDAAQAPATHGVRIDVESHRAWMGEEELQLTAKEFDLLRVLVRDAGRVVTRDQLMREVWDTTWWSSTKTLDMHISWLRKKLGDDAANPRYIATVRGVGFRFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5W2</accession>
    <name>A0A0F4J5W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_23465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000662">
        <property type="protein sequence ID" value="KJY29224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29224">
        <property type="protein sequence ID" value="KJY29224"/>
        <property type="gene ID" value="VR44_23465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.635"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="16782" checksum="6A80368AF2EC869B" modified="2015-06-24" version="1">MVAKKTAGTARKTADDTAGGLAAATPGELAVRPGEEPWTAEEVAEARTELLSEVMRLRVELEASEMAISGLMRDSGDGAGDDQADTGTKNITRESELALAANATSMLEQTERALERLEAGTYGLCENCGKPIGKARMQAFPRATLCVDCKQKQERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J632</accession>
    <name>A0A0F4J632_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000657">
        <property type="protein sequence ID" value="KJY29294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29294">
        <property type="protein sequence ID" value="KJY29294"/>
        <property type="gene ID" value="VR44_23310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="20209" checksum="9BB11EEFE2594DB0" modified="2015-06-24" version="1" fragment="single">DPKDRAARRDRFRARAVTTTVVATVVAAPVIALWAAYRGAPTTGEPVGDGTRISATESKIPPPFTEGRPLTAYENTGNTARTTGEPGFASGSAAPDVSVEVISSGAPATPDPAGPGAPGRLTVAAATRGGTTLLTLSASGGSPVAWRPWSDAPWLRASQTAGTLAPGESVTLRITVDTEAQPVGAWTARVGVDPGGAVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J673</accession>
    <name>A0A0F4J673_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949265.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29862">
        <property type="protein sequence ID" value="KJY29862"/>
        <property type="gene ID" value="VR44_21870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.254"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="16586" checksum="332FE26F4F596ACE" modified="2015-06-24" version="1">MEGTPRPDASVPAAISAMDDLIATSMVAQQEFARNLGLSPTDLICFAYVLQAGDTPVSAGDLAARAHVTTGAVTGIVNRLERGGYVTRQPDPADGRRVRVVAVPEAAQRVRAVYEPYYALLAQLFATYSPDEVAVLNDWFTRAGALAAAYLADSCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7U5</accession>
    <name>A0A0F4J7U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000576">
        <property type="protein sequence ID" value="KJY30275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30275">
        <property type="protein sequence ID" value="KJY30275"/>
        <property type="gene ID" value="VR44_20855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="18720" checksum="DEBBF8D83A7BF4B2" modified="2015-06-24" version="1" fragment="single">MWMSVQQHGGTPAGVSLNGILSQMFGIGGQRLHWTGRSLTAETVQAHTWRGREGSLTFYAVPAKPSGDAETAAVAKVTAALARLSAVEGKEAALAKWNEEIQRVETEIGKKEARLGQITDGTKGRSTRALPMVGLGQDRLGLGWSGALLGFTSAAGSPFITAGGTGHLGLYFRDEQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8E7</accession>
    <name>A0A0F4J8E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000661">
        <property type="protein sequence ID" value="KJY29231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5192"/>
    <dbReference type="EnsemblBacteria" id="KJY29231">
        <property type="protein sequence ID" value="KJY29231"/>
        <property type="gene ID" value="VR44_23450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.632"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18706" checksum="C8370D21E4246C6C" modified="2015-06-24" version="1" fragment="single">KIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRGFEREYRTRLKSYLESQLRQLETQADDSLAPPRTPAGPALPPSPSPSMAPAGAMGMGGPSPMGGPSPMGGPSPMSGAPSYGGQQQMSPAMTQPMAPVRPAAPQPMQQAPSPMRGFLIDEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8L6</accession>
    <name>A0A0F4J8L6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_21140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949123.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000588.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30134">
        <property type="protein sequence ID" value="KJY30134"/>
        <property type="gene ID" value="VR44_21140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8951"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="11">
        <location>
            <begin position="56"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35366" checksum="D0CE0850DD3C9893" modified="2015-06-24" version="1">MRAQFVMSEIGVGLRRNLTMTFAVIISVALSLALFGGSLLMRDQVSAMKGYWYDKVNVTVYLCTKNDAALDSAAGNAPAAAGAPGTAAAPAAGNGKPCSKGAATPEQKQGIERELKKMDLVQNVMYESSDEAYKHYKERFGHTALASVVTADQMPDSFRVKLKNPEKYEVITSAFAGRDGVQSVADQSMELDNLFALLGTLNWAALGIMMIMLIVALLLIVNTVRVSAFSRRRETGIMRLVGASGFYIQVPFIMEAAVAGLIGAGFACGMLGAGQYFVIDHGIALREKLQLINFIGWDAVLAKLPLVLVIGLLMPSLAAFVALRKYLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J922</accession>
    <name>A0A0F4J922_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_20805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000574">
        <property type="protein sequence ID" value="KJY30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949061.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000574.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30304">
        <property type="protein sequence ID" value="KJY30304"/>
        <property type="gene ID" value="VR44_20805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8880"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470274" evidence="5">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="7538" checksum="6A07597EC74D8C4B" modified="2015-06-24" version="1">MRIRTAFAATVLAAVGILGASGSALADANASGTAIGSPGVLSGNVVQVPIHIPINVCGNTINIIGLLNPAAGNTCINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9C8</accession>
    <name>A0A0F4J9C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949398.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29566">
        <property type="protein sequence ID" value="KJY29566"/>
        <property type="gene ID" value="VR44_22585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.408"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="18669" checksum="F26F18A70319A69F" modified="2015-06-24" version="1">MTLTFTFDPVVDPTLRDGIAELWTEVSNAGGAVGFVPPVTIEDIRPELVKHLVAMAEGRHRLLVGHDADGNVAAAAFLAFNQHRLMKHWAYAYTVMVRPALQGRGAGRALMAALADAARTLDGIESVVLECRGGLGLEHFYAACGYKEVGRIPGAIRVAPGDDRDGITMLLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z5</accession>
    <name>A0A0F4J9Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000524">
        <property type="protein sequence ID" value="KJY31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31005">
        <property type="protein sequence ID" value="KJY31005"/>
        <property type="gene ID" value="VR44_19120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8428"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="21622" checksum="B28D4FE8B4032DDC" modified="2015-06-24" version="1" fragment="single">LAAALAGVAVGGIAAVAGTGLLDRAVHLTAGPAPAVSVSADSDRTPAGETAGPTPLPQLRPTPEGGDGLASLSPGISLPPDGRARTPLDSAPSLSLPPGAVTTPGTGGGAAGTDGGTRNTFTDKNGGTQGGGDTGGKDRGGEDQDRPETLCRDHLANRLAEDREQHLAKIAGGLAKVPRFCATLLDAPRSGTPQSGTADQGGGVVVPSPVLSPAGPLGFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z6</accession>
    <name>A0A0F4J9Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxyacyl-ACP dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31192">
        <property type="protein sequence ID" value="KJY31192"/>
        <property type="gene ID" value="VR44_18645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8338"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16663" checksum="8C1F258335A37D13" modified="2015-06-24" version="1">MLLVDRVTELVPEERLTALKAVTCNEPWYEGLAEDADDEGHGYPQTLLVESWCQAAGVLAAWDKPNPDVLSGQVMLFGSISDVVLHRPVYPGDVLEHRVRLVRALSDTVIFEGEALVGGETVMEVGRVVMAMRPAAELTAAREQSPAAQPAGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA68</accession>
    <name>A0A0F4JA68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000609">
        <property type="protein sequence ID" value="KJY29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949248.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000609.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29871">
        <property type="protein sequence ID" value="KJY29871"/>
        <property type="gene ID" value="VR44_21775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.235"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11646" checksum="2590FFD6905DAE1E" modified="2015-06-24" version="1" fragment="single">AQKVQVLLVDDLDGGEADETVTFALDGKTYEIDLTTANAEKLRGLLDPYTKGGRRTGGRASAGRAKGRAAASAGSPDTAEIRAWAKAQGLSVNDRGRVPAEIREAYENAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAS7</accession>
    <name>A0A0F4JAS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949156.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5730"/>
    <dbReference type="EnsemblBacteria" id="KJY30066">
        <property type="protein sequence ID" value="KJY30066"/>
        <property type="gene ID" value="VR44_21315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8988"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="93"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="442" mass="48190" checksum="C3FDBCE53D1E2843" modified="2015-06-24" version="1">MSDLPRKAVTRTVKLAALPLGIAGRATWGLGKRIGGKSAEIVARELQQRTAEQLFRTLGELKGGAMKFGQALSVFESALPEEVVGPYRAALTKLQEAAPPLPAARVHQVLAERLGEDWRELFEEFEDKPAAAASIGQVHRAVWHDGRQVAVKVQYPGAGEALLSDLKQLGRFAGLLGPLIPGMDMKPLITELRDRVAEELDYELEAEAQRTHADAFDGDEDVLVPDVVYQGDQVLVTEWLEGTPLSEVIADGTQEERDRAGQLLTRFLFSGPARTGLLHADPHPGNFRLIAGPDGRTRLGVLDFGTVDRLPGGWPKPIGRSLRMTLDGDAEGVYGHLCAEGFVKESIELDPDAVLDYLKPIIEPAEADAFTFTRSWLRGQAARIADPRSPAHQLGRQINLPPSYLLIHRVTLSTIGVLCQLGATVRLRDELDAWLPGFPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBM6</accession>
    <name>A0A0F4JBM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000568">
        <property type="protein sequence ID" value="KJY30386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000568.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30386">
        <property type="protein sequence ID" value="KJY30386"/>
        <property type="gene ID" value="VR44_20600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8833"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470557" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16108" checksum="5AFB0D1AFE31E603" modified="2015-06-24" version="1">MGISLRKTVALAALALAASLLPAGGAGAVQQAAVPGRYCLANAWGTPNISSKPCDSADQGQHWVVSGNQISLAGARAYCLANNWGTSQVTTKPCNPNDQGQYWNVSGQQIALTFAPAYCFANAWGTPNVGTKPCDQADPGQKWVVFNDQISLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBQ7</accession>
    <name>A0A0F4JBQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide-8 synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000512">
        <property type="protein sequence ID" value="KJY31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948682.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000512.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31173">
        <property type="protein sequence ID" value="KJY31173"/>
        <property type="gene ID" value="VR44_18725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8356"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9470" checksum="AC11A50726F59B3D" modified="2015-06-24" version="1">MAATTEERRETIKDIVCDILEIDPEDVTATSLFKEDHDADSLRAIEILASLEKEFNVVINQTELGRMVNLDGVYEVVAESADWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC12</accession>
    <name>A0A0F4JC12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948600.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31349">
        <property type="protein sequence ID" value="KJY31349"/>
        <property type="gene ID" value="VR44_18300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8208"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="14144" checksum="8D0843C74E595C94" modified="2015-06-24" version="1">MRERLFPRAYQTVSAARDFARETLDAWGLPERRDDVVLCVSELATNALRYGVPRGRSYRVRLLGFGCCVRVEVHDSGPGRSRMLGRAPGNGLQIVEAVSDLWGVLPRSPGKVVWAEFRCDGRDTIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM2</accession>
    <name>A0A0F4JCM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000542">
        <property type="protein sequence ID" value="KJY30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948844.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000542.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30736">
        <property type="protein sequence ID" value="KJY30736"/>
        <property type="gene ID" value="VR44_19595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8530"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13465" checksum="6CAB6D1C4CD04D52" modified="2015-06-24" version="1">MSKQAGLPVLGQDDVACCAPMVREPLGEEAAAELSRMFKALSDPIRLRLLSLIASHEGGEACVCDLIGPFDVSQPTISHHLKVLREAGLVGSERRGTWVYYWVLPEALAKLSALLEIPAASAKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDK4</accession>
    <name>A0A0F4JDK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_17170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948387.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000456.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4325"/>
    <dbReference type="EnsemblBacteria" id="KJY31899">
        <property type="protein sequence ID" value="KJY31899"/>
        <property type="gene ID" value="VR44_17170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7966"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="154"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="704" mass="79535" checksum="0DBC6E62BD404A90" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDV4</accession>
    <name>A0A0F4JDV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948179.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32400">
        <property type="protein sequence ID" value="KJY32400"/>
        <property type="gene ID" value="VR44_16070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7635"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="9"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="34687" checksum="515B92684830D3D1" modified="2015-06-24" version="1">MPPYPSRPTVAVLGECVADAFTITSPRPRTETPPTGLDLRVLPGGGPANTAVSLARLGTPTRFFARLSHDLFGDLFRARLTHSGVDLSACIPAREPSTLAVAAVDEMGQATYSFFADGAADWQWTDAELSAVPLDGISCLHTGSLAFAREPGGPRLEEHLARARPHMTVSLDPNVRPLLVEPVAYRKRLNRWCELADILRLSEDDLTHLLPGTTPEEACDTLHTAGAPLVVITLGSRGALASLGGTRAYLPARPTHVVDTVGAGDSFTAGLLHHLNTLGRLGGRLDELTIDETIDACAYAAEVAARTCAVPGANPPWAHQLPSTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEE6</accession>
    <name>A0A0F4JEE6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_18340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000063_gene1479"/>
    <dbReference type="EnsemblBacteria" id="KJY31356">
        <property type="protein sequence ID" value="KJY31356"/>
        <property type="gene ID" value="VR44_18340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8217"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="36148" checksum="892DAD6D8AC23D34" modified="2015-06-24" version="1">MSAYGSFPGSRPRRLRTTPAMRRMVAEYRLHPSDLILPAFVREGISEPLPISAMPGVVQHTRDTLRKAAVEAVEAGVAGIMLFGVPADENKDALGTAGTEPDGILQLAIRDVKSEVGDDLVIMSDLCLDEYTDHGHCGVLDADGRVDNDATLERYAEMAQVQADAGVHVVGPSGMMDGQVGVIRDALDETGHEDVSILAYTAKYSSAFYGPFREAVASSLQGDRKTYQQDPANARESLRELALDLEEGADMVMVKPAGPYLDILHRVAEAVDVPVAAYQISGEYAMIEAAAEKGWIERDRAIMETLLGIKRAGADTILTYWATEVAGWLRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEN4</accession>
    <name>A0A0F4JEN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_16260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000423">
        <property type="protein sequence ID" value="KJY32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32264">
        <property type="protein sequence ID" value="KJY32264"/>
        <property type="gene ID" value="VR44_16260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="5">
        <location>
            <begin position="337"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="538"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="922" mass="97621" checksum="65D5C01FABB21D34" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFU3</accession>
    <name>A0A0F4JFU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947907.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5635"/>
    <dbReference type="EnsemblBacteria" id="KJY33065">
        <property type="protein sequence ID" value="KJY33065"/>
        <property type="gene ID" value="VR44_14600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7246"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26943" checksum="1180EAD38577AEE6" modified="2015-06-24" version="1">MTFGEQPAYLRVAGDLRRKIVDGSLPPHARLPSQARIREEYGVSDTVALEARKVLMAEGLVEGRSGSGTYVRAQPVPRRVARTGYRSGGASTPFRQEQAESGVHGTWESSSEQAAAPADIAKRLGIEPGDRVMRTRYVFRDAGEAMMLSTSWEPLSVTGRTPVMLPEEGPLGGSGVVDRMAAIDVVVDNVVEEVGARPGLAEENMTLGGVPGHVVLVVTRTYYASGRAVETADVVVPADRYRLSYHLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGH6</accession>
    <name>A0A0F4JGH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_15110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32868">
        <property type="protein sequence ID" value="KJY32868"/>
        <property type="gene ID" value="VR44_15110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2b" evidence="5">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HGTP_anticodon" evidence="6">
        <location>
            <begin position="105"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22313" checksum="445BCA076205DCAC" modified="2015-06-24" version="1">MAAVHRPADRRPRPLREAAEGEAAFYGPKIDVQVTDDAGRESTLSTVQVDFHQPEQFDLHYIGADGAKHRPVMVHRSIIGSVERAVAHLIEQHGGAFPAWLAPTQLVVLPISDSELPDAAALARHCTGLGLRVRIAGPERGSLGARIREARLVPYQAVIGAREAADGHVALRLRDGRRLGPQPVGEALARISALIGAHSTDLWADPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGL3</accession>
    <name>A0A0F4JGL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="6" type="synonym">obg</name>
        <name evidence="11" type="ORF">VR44_14100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947824.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2579"/>
    <dbReference type="EnsemblBacteria" id="KJY33360">
        <property type="protein sequence ID" value="KJY33360"/>
        <property type="gene ID" value="VR44_14100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7134"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="349"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="481" mass="51369" checksum="B9BBC3BFCC157821" modified="2015-06-24" version="1">MTTFVDRVELHVAAGNGGHGCASVHREKFKPLGGPDGGNGGRGGDVILVVEQAITTLLDYHHSPHRKATNGKPGEGGNRSGKDGQDLVLPVPDGTVVLDKQGNVLADLVGQGTTYVAAQGGRGGLGNAALASARRKAPGFALLGEPGDSGDVVLELKTVADVALVGFPSAGKSSLISVLSAAKPKIADYPFTTLVPNLGVVTAGSTVYTIADVPGLIPGASQGKGLGLEFLRHVERCSVLVHVLDTATLESDRDPVGDLDLIEEELKLYGGGLEKRPRLVVLNKVDIPDGQDLAEMVRPDLEARGYKVFEVSAVARTGLKELSYFLAEVVAKARARKPKQEATRIVIRPKAVDDAGFTVTYDEVEDVYRVRGEKPERWVRQTDFNNDEAVGYLADRLNRLGVEDALKKAGAKAGDGVAIGSEENAVVFDWEPTMMAGAEMLGRRGEDHRMEAPRPATQRRKEKEARRGDAAQQEYDEFRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHR5</accession>
    <name>A0A0F4JHR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948136.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32481">
        <property type="protein sequence ID" value="KJY32481"/>
        <property type="gene ID" value="VR44_15845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7577"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="33984" checksum="B57CE3E4E4F80364" modified="2015-06-24" version="1">MTQTTWSIGELADGTGVPVKTLRYYSDSGLLPVAARSAGGHRRYGPEAWERIRLIRRLRALDTPIATVTRVVTGECSLHELVETELEAVQERLVELRWRQATLKALDDCPSEERLHRLEILARVQRLPEAHRALTDHWFRELSGTMPRHRLERMVAMLSPEPPNDPGPHSALAYAELHLLISSPAFTRWTQDHEEEMRGAPALYAELDDAAALTAAAVFQGRPPHAGAAVDAFVSAHARALRELDTPAFRTFLHGLASRSSGFDPRLERYWGLVDTVTGGRGLNMTVAHRWLTEGLSKSLTATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI69</accession>
    <name>A0A0F4JI69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molecular chaperone Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948087.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32661">
        <property type="protein sequence ID" value="KJY32661"/>
        <property type="gene ID" value="VR44_15515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7503"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1031" mass="109406" checksum="BB1F381BE84411F8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIB6</accession>
    <name>A0A0F4JIB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947752.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33549">
        <property type="protein sequence ID" value="KJY33549"/>
        <property type="gene ID" value="VR44_13710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7018"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="29134" checksum="C5B1846E69988FEE" modified="2015-06-24" version="1">MKVPKAGAMAAVIGLALTATGCGGDEGPKGTLSIGVAFDQPGIGLREAGGTFSGFDVDVSRYIAKELGYKPEQIEFKRVDSSERELLLQYNEVKFVASTYSINDQRREKVDFAGPYFTAHQDLLVRADDATITKAEDLNNKKLCSTSGSTSAQNVKQKLAPKASLLELDGYSECVIALQDGLIDAMTTDNAILAGYAAQKGNTGKFRLVGLNLSNESYGIGIKKGNRDLRAKINDALKKMVEDGSWDAAVKKNFGQANFKHDPAPQLTSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ09</accession>
    <name>A0A0F4JJ09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000295">
        <property type="protein sequence ID" value="KJY34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34337">
        <property type="protein sequence ID" value="KJY34337"/>
        <property type="gene ID" value="VR44_12100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6506"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12202" checksum="B9B3125DBCC71991" modified="2015-06-24" version="1" fragment="single">MTYRAALPGLIALPGVYRPQADTLLLADALAREPLRPGAQVVEIGTGTGAIALRAAARGAEVTAVDVAWPAVLAARLNGWRRRLRLRVLHGDFAARTRGRRFDLVLANPPYVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ66</accession>
    <name>A0A0F4JJ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000378">
        <property type="protein sequence ID" value="KJY32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2607"/>
    <dbReference type="EnsemblBacteria" id="KJY32981">
        <property type="protein sequence ID" value="KJY32981"/>
        <property type="gene ID" value="VR44_14760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7348"/>
    <dbReference type="eggNOG" id="ENOG502ZQDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="58" mass="6106" checksum="038BE0A589E1D2DF" modified="2015-06-24" version="1">MVVLLAVILVILIRGKHMKAGPAIVAVLFGFFLASSSIAPDVNRFLNSLADTIAGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJG1</accession>
    <name>A0A0F4JJG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34467">
        <property type="protein sequence ID" value="KJY34467"/>
        <property type="gene ID" value="VR44_11900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6385"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8169" checksum="EE0937E6CD87197F" modified="2015-06-24" version="1" fragment="single">MTGDDTQPVSGPSRRYWTGPGPRRWNRDMTEHAPTRPAGADPAVSVVRPGQGEKILLGTTVMRLLEDGAITGNRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMV2</accession>
    <name>A0A0F4JMV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000216">
        <property type="protein sequence ID" value="KJY35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947065.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7028"/>
    <dbReference type="EnsemblBacteria" id="KJY35515">
        <property type="protein sequence ID" value="KJY35515"/>
        <property type="gene ID" value="VR44_10010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5550"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="456" mass="47235" checksum="10A08281DD478B01" modified="2015-06-24" version="1">MDDDLIARLRTGLPPEALLTDPQVTASYASDMADFCPAGAPAVVVLPRTVEQVRHVMRTATALRVPVVPQGARTGLSGAANASDGCIVLSLVKMDRILEVSAVDRIAVVEPGVVNAVLSRAVAEQGLYYPPDPSSWEQCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLLRTGRRTAKGVAGYDLTRLFVGSEGTLGVVVGAVLALRPAPPRQLALAAEFPSVAAACEAVCAVMEAGLAPSLLELMDGTTVRAVNALGKMGLPESTQALLLAAFDTPDAPAALAAVGELCTAAGASAVVPAEDEAESELLLRARRMSLTALDALRPATMIDDVCVPRSRLAEMLDGTAAIARTYGLLIGVCAHAGDGNTHPVVCFDPADEDEARRARESFDQIMALGLALGGTITGEHGVGVLKKEWLARELGPVGLEMQRAVKQAFDPLGLLNPGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNG9</accession>
    <name>A0A0F4JNG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947404.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34456">
        <property type="protein sequence ID" value="KJY34456"/>
        <property type="gene ID" value="VR44_11840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6373"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="243" mass="25704" checksum="CFDC322A13635C6F" modified="2015-06-24" version="1">MSAAHDGRQWPDEVSVDNARTTLLQLLARTGVPSGDARQLIGLVEAGVLALAHAELGAAGRSAPGDKGEEYRSGWLDGAEALLEELGAVAERTLAGVTGPEGDQGGPGGHPRARRMEVERAKVALTPLYLSFTAASELDPEVTEEVLVAVLGTMSPRQRAGYAGRLTEFATLHRGRLERLFAAFGPDSTTALHGRYSLLHSATSIAVLERLLASPQALREEWDAAELPPAWLDGLTTAWTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPE8</accession>
    <name>A0A0F4JPE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35719">
        <property type="protein sequence ID" value="KJY35719"/>
        <property type="gene ID" value="VR44_09350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5198"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="41322" checksum="B94516C85FF43601" modified="2015-06-24" version="1">MTLGTVGALTAAAPPLPGDPHPRKDHGFQEVDLVSDIPGRAQVTDPHLANPWGLATNRAGQLLVSDNHTDLATTYSGGQKGQPVRVLNRVVTFPRDGAPTGVVRNDGDDLEFTDPNPPGRTGPARFLFAGEHGDLFAYNAEVNRTNAIPVAHEDSGGETAIFKGLELVRLKEDREGRKDQAAQEGQEERSHERGEPRVLVANFRGARVDVFDEDFRLLPPDGAFRDPNLPAGYAPFNIKEIDHKVFVTYALQDEDKEDDVPGAGHGFIDVYSKEGRLLKRFASDGVLNSPWGLEIAPKGFGKFAGDLLVGNFGDGRINVFDRHSGKFKGTVEDRNGRPIAIPGLWGLKRGTDKSGGREAVWFAAGINDEENGLLGVIRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPP0</accession>
    <name>A0A0F4JPP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_09155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000198">
        <property type="protein sequence ID" value="KJY35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946903.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000198.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35809">
        <property type="protein sequence ID" value="KJY35809"/>
        <property type="gene ID" value="VR44_09155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5095"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="9">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="47775" checksum="9460394084EBBE5D" modified="2015-06-24" version="1">MPYFDTASAAPLHPVARQALQAALDEGWADPARLYREGRRARLLLDAAREAAAEAVGCRADELVFTPSGTHAVHAGVAGALAGRRRVGGHLVVSAVEHSSVLHAAEAHAAAGGTVTEVPVDRFGAVSPVEYASSLSSTTALACLQSANHEVGTVQPVAEVAGLCAEAGVPLLVDAAQSLGWGPVEGPWSVLTASAHKWGGPPGVGLLAVRKGVRFAPQGPADERESGRSPGFGNLPAVVAAAASLRAVRAEADAEAARLRVLVDRIRRRVARLVPDVEVVGHADRRLPHLVTFSCLYVDGETLLHELDRAGWSVSSGSSCTSSTLTPSHVLRAMGVLSEGNVRVSLPRGTTAEEVNGFLEVLPRAVAGVRAELGVPDAVPSVPPVAESMEVDALGLRCPQPVIELARAIVSVPVGGTVTVLSDDEVARLDIPAWCAMRGHTYLGETPHGDAVAYRVRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPW6</accession>
    <name>A0A0F4JPW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34951">
        <property type="protein sequence ID" value="KJY34951"/>
        <property type="gene ID" value="VR44_11060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6096"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1089" mass="114982" checksum="48C395AE90AB2565" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQI5</accession>
    <name>A0A0F4JQI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946774.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36114">
        <property type="protein sequence ID" value="KJY36114"/>
        <property type="gene ID" value="VR44_08460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4755"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470795" evidence="3">
        <location>
            <begin position="43"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="170"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="28961" checksum="B8DCC502740FB4D6" modified="2015-06-24" version="1">MSHTAHIPSHRKPRRSASKLAVRAGVAGGVLSTLAMAGTASASPSTEPVAETTLEMPVLSLDLGTEVSNAVNTAAENTRVAAVEAAVTGELNAQEESARTGAAAEAKQAKEDAQKAAEQKAKQEADRKADAERANRSSGRSSLTNASASDDGSGAAVTGGSSSSGRSSATGSAAAIVNFAYAQVGKAYVMGATGPSAYDCSGLVQAAYRQAGISLDRTSQDQSLAGTSVSLSNLQPGDILYWGPKGSAYHVAIYVGGGKFVGAQNPSTGIVERPLSYDMPTGAVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQX5</accession>
    <name>A0A0F4JQX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36254">
        <property type="protein sequence ID" value="KJY36254"/>
        <property type="gene ID" value="VR44_08270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4553"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12531" checksum="AC668F0940D611B7" modified="2015-06-24" version="1">MVEWTGKPAYQQVAEQLRGRIAAGEFAESGKLPSLADLQATYGVTVTVARDAIRQLKTDGLVVSHQGKGAFLTAAASDSARLVGPEVAIAELREQVARLQSEVVELRERVVELEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSA4</accession>
    <name>A0A0F4JSA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36638">
        <property type="protein sequence ID" value="KJY36638"/>
        <property type="gene ID" value="VR44_07560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3989"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15321" checksum="D86D000C547F2ED6" modified="2015-06-24" version="1">MSATAENPPATAAAVEERVSARVISDDPLYRAIPVALRFTPSEPLAVRIVFPAELSPEGTDNEWVFPRALLEAGLLAPTGTGDVRVWPCGRVQAVVEFHSPEGVAVIQFDSAVLRRFLRRTYATPPAGERPAAATRTAATRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSH6</accession>
    <name>A0A0F4JSH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946318.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37322">
        <property type="protein sequence ID" value="KJY37322"/>
        <property type="gene ID" value="VR44_06005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2415"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471317" evidence="4">
        <location>
            <begin position="36"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="6">
        <location>
            <begin position="257"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="493" mass="51170" checksum="89EEA975BCA81F38" modified="2015-06-24" version="1">MRTIRHRRRSIPALAALAAAAVAAPVLLTATPAAAHPREGRLAKELVEEVTARGAYRHLAKFQQIADANGGNRAAGSPGHAASAAYVHDTLKKAGYDVSYQDFDIYEAHTKTEKTTVLGDQPRELATAAFTFTKSTPAGGLTAPLALARVDETPGCTADDYPAGAFTGKIALVKRGACTFVEKQRAAAAAGALGVIVYNHSGTTPVRGGFSSPSDGIIPSAGITLADGEALAAAAAKGEVKVRLDLDQEHVKKTTRNVIAETKGGRADQVVTVGSHLDSVPEGPGINDNGSGSAGLLEVALKLADEGANKKGKGPANKVRFAWWSAEELGLLGSEHYVAQLSEKQKKDIALYLNFDMIASPNPVQFVYDGDDSDKTGAGAGPAGSAQIESLINGFLDRKGKPHEGSDFDGRSDYGPFIENGIPAGGTFTGAEGIKTPEQAKRYGGTAGAPYDPNYHGAGDTLKNLDLKAFDTNLDVIAYAVGTYAESLGSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSJ8</accession>
    <name>A0A0F4JSJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">VR44_07215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946537.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36809">
        <property type="protein sequence ID" value="KJY36809"/>
        <property type="gene ID" value="VR44_07215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3784"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="12673" checksum="56919512A9EB8E53" modified="2015-06-24" version="1">MNWLLVVAGAVVGAPLRYLTDRFVQARHDSVFPWGTFVVNAGACLVLGVLTGAVLAGAGSSRLALLLGTGLCGALSTYSTFSYETLRLAERGWKFLAAANAAASVLVGLGAVTLGSQVAGQLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSP6</accession>
    <name>A0A0F4JSP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946377.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37200">
        <property type="protein sequence ID" value="KJY37200"/>
        <property type="gene ID" value="VR44_06320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3018"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="253"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111202" checksum="43D8284E633C4539" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT91</accession>
    <name>A0A0F4JT91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000106">
        <property type="protein sequence ID" value="KJY37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946266.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000106.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37405">
        <property type="protein sequence ID" value="KJY37405"/>
        <property type="gene ID" value="VR44_05730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1961"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35576" checksum="5E46C020BA2C5AAC" modified="2015-06-24" version="1">MTDELRPHRVVVLVLAGLLPFELGIPHRIFGLAKDSAGRRLYEILTCGLAPGPVRTDADFAIQVEHGPELLATADTVVVPASYELGPVHDEGRLTDGLAAALAHIRPGTRLVSICTGGYVLAAAGYLDGRPATTHWAYAEHFQRMFPAVRVDADVLYTDDGDVLTSAGVAAGVDLCLHIVRRDHGAAVANDTARRTVVPPHRDGGQAQFIGRPVPEPQQASTTAARAWVLDRLHEPVRLSDLARQEAMSVRTFTRRFRQESGVSPGEWITGQRVERARQLLERTELPMEAVAREAGFGTAQSLRKHVQAALGVSPTAYRRTFRATGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTB1</accession>
    <name>A0A0F4JTB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946201.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37597">
        <property type="protein sequence ID" value="KJY37597"/>
        <property type="gene ID" value="VR44_05375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26275" checksum="81F916E749464500" modified="2015-06-24" version="1">MTRTIVVHSHRGGTGKSSVLANLALLLAAAGRRVGVVDTDLQSPTLDLLFGVAPGAGSLADYLLGRCEIEAAARRTSVPGLYVVPARTGTAALRELMATGYDVGLLPEGFERLAHSHALDVLLLDTHAGLNNESVTAMGSADVVLIMTRADRIDLSGVEETIALAGRLACRRALVLSMAPEGVDHEAVRRRAEEVYGTPLAGILPYVPEMAALYGERIFAEAFPDHPLVGEFRTILTALDARDEVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX2</accession>
    <name>A0A0F4JTX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946380.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene60"/>
    <dbReference type="EnsemblBacteria" id="KJY37203">
        <property type="protein sequence ID" value="KJY37203"/>
        <property type="gene ID" value="VR44_06335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3021"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="31726" checksum="4B1F604B929997D1" modified="2015-06-24" version="1">MRLETGQVAVVTGAASGIGLAMACRFAAEGLKVVLADVEEGALRKAADELRAEGAEVLARTVDVSDRDSVVSLADAAYGAFGAVHVLCNNAGVGSGAEGRMWEHEPNDWKWAFSVNVWGVFHGIQAFVPRMIADGAPGHVVNTSSGDGGIAPLPTASVYAVTKAAVVTMTESLYAHLKAEGASVGASVLFPGPHMLRTGLWESHRNRPERYAKERPRKSPYRTLDQYESAMRAAGHEVRFTPVEEVAEHVVEGIRADRFWMLPASEHSDRQIRARSQSMLDRANPAYLESFILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV42</accession>
    <name>A0A0F4JV42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">VR44_03935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945939.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38232">
        <property type="protein sequence ID" value="KJY38232"/>
        <property type="gene ID" value="VR44_03935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8692"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="230"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="238"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="645" mass="68957" checksum="E17B1C1F004AAFA7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVP9</accession>
    <name>A0A0F4JVP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000123">
        <property type="protein sequence ID" value="KJY37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946446.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000123.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4991"/>
    <dbReference type="EnsemblBacteria" id="KJY37041">
        <property type="protein sequence ID" value="KJY37041"/>
        <property type="gene ID" value="VR44_06665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3251"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="29713" checksum="B4D71F14D5C2F82E" modified="2015-06-24" version="1">MRRDATPRRYLMCPPAHFKVTYSINPWMDPTKPVDLPLALAQWEDLRDRYLSLGHTVETLEPDPDLPDMVFAANGALVIDGRVLGARFAYPERTAEAEIHLDWFRSHGFTDIHEPSHVNEGEGDFAVTAGYILAGRGFRSSPLSHDEAQEFFGRPVIGLDLVDPRYYHLDTALCVLDGDEIMYHPPAFSPGSQAVLRRLFPDALLVDAPDAAAFGLNSVSDGRHVLLPQAATGLLAPLRERGFEPVPMDLGELLKGGGSVKCCTQELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVX4</accession>
    <name>A0A0F4JVX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_04715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946081.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37908">
        <property type="protein sequence ID" value="KJY37908"/>
        <property type="gene ID" value="VR44_04715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1024"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="25154" checksum="8D7048D1F007CB4C" modified="2015-06-24" version="1">MLRRNLKHTVRNPVTVFNAVLFPIIIMLMFVGVFGGAFSVGEDYVDYATPGLLVMAISYGLGATATAVNDDMTKGIINRFKTMDVSRGAMLTGHVVITTVRCLVACAAIVGVAFAMGFDPAASALDWLGVVGVVVLLSFAAGWLTVATGLAAKTVESAGLATVPLIMLPFLSTAFVPAETMGTGIRQFAEYQPFTPIIETLRGLLNGNPSGGDALAAVAWCVGLALLGYVWAVSTFKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWB3</accession>
    <name>A0A0F4JWB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_03560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266432.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5749"/>
    <dbReference type="EnsemblBacteria" id="KJY38425">
        <property type="protein sequence ID" value="KJY38425"/>
        <property type="gene ID" value="VR44_03560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8250"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11079" checksum="51B131D5EDF82F42" modified="2015-06-24" version="1">MAWLLVVVAGILETGFAVCLKLSHGFTRLWPTIAFACFALGSFGLLTLALKKLDVGPAYAVWTGIGAAGTAIYGMVFLGDLVSTLKLVSITLVILGVIGLQLSGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXI6</accession>
    <name>A0A0F4JXI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000034">
        <property type="protein sequence ID" value="KJY39087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39087">
        <property type="protein sequence ID" value="KJY39087"/>
        <property type="gene ID" value="VR44_02280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5721"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="646" mass="68629" checksum="1F3C4B8536B5D64D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXN2</accession>
    <name>A0A0F4JXN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">VR44_05045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946140.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene165"/>
    <dbReference type="MEROPS" id="M41.015"/>
    <dbReference type="EnsemblBacteria" id="KJY37751">
        <property type="protein sequence ID" value="KJY37751"/>
        <property type="gene ID" value="VR44_05045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1324"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="205"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="677" mass="73216" checksum="91404744A2BD8D86" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYN9</accession>
    <name>A0A0F4JYN9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_04200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945988.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38106">
        <property type="protein sequence ID" value="KJY38106"/>
        <property type="gene ID" value="VR44_04200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.129"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="21791" checksum="4FF2F6C050127215" modified="2015-06-24" version="1">MSTAETLFTRTDPTLGTFSIRPLDPFSDAELLHAWVTHPKAAFWMMQDATLPDVEREYVRITAHEHHQAFLGFHEDRPAFLMESYDPARLELVGLYDAQPGDVGMHFLVAPTDTPLSGFTRAVITTVMAALFADPATARVVVEPDVRNTAVHALIHALNEAVGFVAEGPVTKPEKEALLSFCTRAQFEAATALTTGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ23</accession>
    <name>A0A0F4JZ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945518.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6519"/>
    <dbReference type="EnsemblBacteria" id="KJY39410">
        <property type="protein sequence ID" value="KJY39410"/>
        <property type="gene ID" value="VR44_01645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5730"/>
    <dbReference type="eggNOG" id="ENOG5032ZD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="18792" checksum="1F4FFFFC03308FA0" modified="2015-06-24" version="1">MLTTLQTTYTDTRAADLAWALGRDRLPALAVLNLQLHDAKVELRLLGASHQVLLEEGEVLCSETVACMPGSRTPLPLGVAKRVGDWEYEFAARVETLSRGSFAGRAQELLALVADHPNGLAGTFPGDPHAFTAMLAQRHEGQVRWRTWHAYPQEGQLVATRTRVGVRMGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K067</accession>
    <name>A0A0F4K067_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945793.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38641">
        <property type="protein sequence ID" value="KJY38641"/>
        <property type="gene ID" value="VR44_03100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7835"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="44804" checksum="4764544C65868FF7" modified="2015-06-24" version="1">MGFDPWDAAFVADPYPAYRELRERGRAEWSPATGQWLVSHYADVSALLRDRRLGRTYLHRFSHEEFGREAPPPEHEPFHVLNGNGLLDLEDPAHGRVRRLVSKAFTPRTVERLAPAVERLARELVAGLLADGGGDLLTAVAEPLPVAVIAELLGIPEADRGLLRPWSAAICGMFELRPDAETARRAVTASVEFSAYLRELIAERRRRPGTDLISALIAAHDEGGRLSEQEMISTCVLLLNAGHEATVNTTVNGWWALFRNPGQLAGLRALPGSPGPEKLSTAVDELMRYDTPLQMFERWVLDDIEVGDTVIPRGAEIALLFGSANRDPARFEDPDALDLGRADNPHLTFGAGIHYCLGAPLARLELVSSFGALLDEKLPPMRLVREPQWQDGYVIRGLRELLVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0C9</accession>
    <name>A0A0F4K0C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4675"/>
    <dbReference type="EnsemblBacteria" id="KJY39559">
        <property type="protein sequence ID" value="KJY39559"/>
        <property type="gene ID" value="VR44_01360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2988"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="453"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="549" mass="59730" checksum="78BAC597539E6FEC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0N8</accession>
    <name>A0A0F4K0N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945478.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4170"/>
    <dbReference type="EnsemblBacteria" id="KJY39488">
        <property type="protein sequence ID" value="KJY39488"/>
        <property type="gene ID" value="VR44_01410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4714"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="33317" checksum="685DF7E95C579905" modified="2015-06-24" version="1">MDLRIFTEPQQGADYDTLLTVAKATEELGFDAFFRSDHYLRMGSVDGLPGPTDAWITLAGLARETKRIRLGTLMTAGTFRLPGVLAIQVAQVDRMSGGRVELGLGAGWFEEEHKAYGIPFPAERMARLEEQLAIITGLWATEPGATFDYQGTHYQVENSPALPKPAQAKVPVLIGGHGARRTPRLAARYADEFNMPFASVEDSRRQFARVREAAAEAGRKAEELVYSNALVVCVGKDDAEVARRAAAIGREVDELKANGLAGSPAEVVEKLGTYAAIGSSRVYLQVLDLDDLDHLELIAGQVMSQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0R7</accession>
    <name>A0A0F4K0R7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_00775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945363.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4789"/>
    <dbReference type="EnsemblBacteria" id="KJY39709">
        <property type="protein sequence ID" value="KJY39709"/>
        <property type="gene ID" value="VR44_00775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2860"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19528" checksum="37EBB247E0923C6B" modified="2015-06-24" version="1">MAEKLYATLKTNHGDIEIELLENFAPKTVRNFVELATGAREWTRPTDGQKTTSPLYDGTVFHRVISGFMIQGGDPLGNGTGGPGYQFADEFHPDLAFTKPYLLAMANAGPGTNGSQFFITVAPTAWLTRKHTIFGEVTDKASQKVVDAIASGATNPRTERPLDDVIIQSVSVERREATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1Z3</accession>
    <name>A0A0F4K1Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">VR44_00285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945286.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1025"/>
    <dbReference type="EnsemblBacteria" id="KJY39933">
        <property type="protein sequence ID" value="KJY39933"/>
        <property type="gene ID" value="VR44_00285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.55"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11675" checksum="1C540CCE79C6DD10" modified="2015-06-24" version="1">MSEATVTSKTFSDPRDLLIKPVVSEKSYALLDENKYTFIVAPGANKTQIKQAVEAVFSVKVTGVNTINRQGKRKRTKTGFGKRANTKRAIVTLAEGNRIDIFGGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K350</accession>
    <name>A0A0F4K350_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945435.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39586">
        <property type="protein sequence ID" value="KJY39586"/>
        <property type="gene ID" value="VR44_01180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2951"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="295" mass="31242" checksum="15E326AD13F2C77F" modified="2015-06-24" version="1">MAPENSTQIHNIGYRSYDGPRLGRSYARTSLFSQSLRGAYGLGRSAKSKVLPMILFAVMCVPALIIVAVAIAVPGSTDLPIKYTTYALTTQVVIGLYLASQAPQSVSRDLRFKTVPLYFSRPIERIDYVLAKYAAMVSALFILTATPLLIMWIGSLLAKFDFGHQTKGFGQALVSVLLLSLLFAGLGLVMAALTPRRGFGVAAVIAMLLIPYGAVSTVQAVAYGTGNTGVIEWLGLFSPITLIDGVQTAFLGATSAFPGGEGPSAGTGFVYLLVILGLIVGSYAALMARYRKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K440</accession>
    <name>A0A0F4K440_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="12" type="ORF">VR44_00210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945279.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1006"/>
    <dbReference type="EnsemblBacteria" id="KJY39921">
        <property type="protein sequence ID" value="KJY39921"/>
        <property type="gene ID" value="VR44_00210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.39"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="11">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144303" checksum="C4A0CE8506257071" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I283</accession>
    <name>A0A0F4I283_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001854">
        <property type="protein sequence ID" value="KJY15799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15799">
        <property type="protein sequence ID" value="KJY15799"/>
        <property type="gene ID" value="VR44_40815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7235"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7058" checksum="E7F32B65B4A4275F" modified="2015-06-24" version="1" fragment="single">PSLAEAAGSQGGCAHHADPLPVAGQAREVARRLLAEAPARTRPTLLLAALATRPTTALLRRAGRPDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I338</accession>
    <name>A0A0F4I338_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001762">
        <property type="protein sequence ID" value="KJY16347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16347">
        <property type="protein sequence ID" value="KJY16347"/>
        <property type="gene ID" value="VR44_40495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9507" checksum="73C0F108C57A2F6D" modified="2015-06-24" version="1" fragment="single">MKYSFKGWGVDFPKGSKVRVVTSVMTADSTGFGGPTWDSPFETTLYASQSGSWSTPTTTKNAVKSDYEIQVTVDVYEGQKKVGTDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I496</accession>
    <name>A0A0F4I496_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001766">
        <property type="protein sequence ID" value="KJY16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16293">
        <property type="protein sequence ID" value="KJY16293"/>
        <property type="gene ID" value="VR44_40515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6900"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="14911" checksum="399504F48FF4E98E" modified="2015-06-24" version="1" fragment="single">AYTLPVTAGALAVGVVRRRRDPGASSWAAYGPGLGATLLPGLVAVWGDPYWPRPLLLGLGALVVTLVGAHRRLRAPLLLGGFALAGVAVHELAPYVVQVAGLLPRWVPPALAGVLLLAVGATYERRLRDARRLREALGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7G4</accession>
    <name>A0A0F4I7G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001728">
        <property type="protein sequence ID" value="KJY16651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16651">
        <property type="protein sequence ID" value="KJY16651"/>
        <property type="gene ID" value="VR44_40340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6658"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="21553" checksum="A47B5D823BE121D8" modified="2015-06-24" version="1" fragment="single">RGALGGRGALLAVGALALLLTGCGIRATTVPVDVGPAPSRVSCDTPDLPPGQSGVQGFRAKVELVCGSQLVAVERVVPVPEKRTGREPVTLVAQALLEELERTPSEQEREGGFTTGVPDGLTAAPARPGDPAGTVRLSRKPEDLPPVALAQIVCTLSASDAVSAGPGPVVLGGPDADPPRAWECTDAVRSRPESAPTLGELVRPTATPSPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7Z0</accession>
    <name>A0A0F4I7Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001624">
        <property type="protein sequence ID" value="KJY18092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952557.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001624.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18092">
        <property type="protein sequence ID" value="KJY18092"/>
        <property type="gene ID" value="VR44_39690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6120"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7657" checksum="775DFDA9CD44FE4A" modified="2015-06-24" version="1">MPTDSVGRFLAALDPAHREAVAARPRAEQERLAAAWEEELGADDELDTLDELSPPAAEAEAARRVMQRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBZ6</accession>
    <name>A0A0F4IBZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001547">
        <property type="protein sequence ID" value="KJY19545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1337"/>
    <dbReference type="EnsemblBacteria" id="KJY19545">
        <property type="protein sequence ID" value="KJY19545"/>
        <property type="gene ID" value="VR44_39075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5576"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11435" checksum="36A72D08BF220832" modified="2015-06-24" version="1" fragment="single">GGERQRLTIARLLLARQRVVILDEATAHLDSTSEAAVQEALSEALAGRTAVVIAHRLSTVQAADLILVVEEGRIVERGTHTELLASGGRYEELYRTQFAARGTAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDD1</accession>
    <name>A0A0F4IDD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001543">
        <property type="protein sequence ID" value="KJY19689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19689">
        <property type="protein sequence ID" value="KJY19689"/>
        <property type="gene ID" value="VR44_39030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5567"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="557" mass="58899" checksum="F15F6E9C98B6C5D1" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIC7</accession>
    <name>A0A0F4IIC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001465">
        <property type="protein sequence ID" value="KJY21223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952309.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001465.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21223">
        <property type="protein sequence ID" value="KJY21223"/>
        <property type="gene ID" value="VR44_38365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5284"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23679" checksum="FE86E68F567F20E5" modified="2015-06-24" version="1">MENTTGLRESKKLRTRRQLAATALELFLERGFDAVSVADVAAAAEVSKPTLFRYFPSKEDLVLDRFADHQDEAARIVRDRPAGLGPVGALHDHFRTALAERDPITGLCDHPDVLAFQRLLYSTASLESRIAHYTAREVELLAAALEAEEVEPLSARLAATHLVAVRHELGRENWRRIDAGSTAEEVYPAAVVDADRAFGMLADGLDRTLGPLISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKY4</accession>
    <name>A0A0F4IKY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-3B C17-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_38045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001432">
        <property type="protein sequence ID" value="KJY22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22133">
        <property type="protein sequence ID" value="KJY22133"/>
        <property type="gene ID" value="VR44_38045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5175"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="18357" checksum="FDB3C1CC532B8FFA" modified="2015-06-24" version="1" fragment="single">VAVVSGGDPGVFAMATAVLEVAGQAPYADVPVRVLPGVTAANAAAAAAGAPLGHDYATVSLSDRLKPWEVIAERLRAAAAADLVLALYNPGSRSRTWQVAQARELLLELRAPQTPVVVARDVGGPEQSVRIVTLAELEPSEVDMRTILLIGSSQTRVTERPDGSRVTWTPRRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPQ8</accession>
    <name>A0A0F4IPQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">VR44_36585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001312">
        <property type="protein sequence ID" value="KJY24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951977.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24010">
        <property type="protein sequence ID" value="KJY24010"/>
        <property type="gene ID" value="VR44_36585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4625"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="29582" checksum="4435CD90A9F8812D" modified="2015-06-24" version="1">MGRVTERRRVIRVRGGAAGVRPDTLVTEEPLEIRLNGKPLAITMRTPGDDFALAVGFLVSEGVIARASDVQAVTYCEGATEDGSNTYNVVNVQLAAGVPVPDITLERNVYTTSSCGLCGKASLDAVRTATRFPGLAADPVRVPAGLLSELPDRLRAAQKVFDRTGGLHAAGLFSAEGELLDLREDVGRHNAVDKIVGRALQAGRLPLAGAVLLVSGRASFELAQKAVMAGIPVLAAVSAPSSLAVDLAADSGLTLVGFLRGPDMNIYAGEERILLPAPEAVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPU0</accession>
    <name>A0A0F4IPU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001393">
        <property type="protein sequence ID" value="KJY23488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23488">
        <property type="protein sequence ID" value="KJY23488"/>
        <property type="gene ID" value="VR44_37625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5030"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="9764" checksum="0A64A3FF6BADCF6A" modified="2015-06-24" version="1" fragment="single">MLLVLPPGGPLRFGAVPAPHVALAEAGGPEFASFALTGLDAETALTALELYRRQGAWKVRAVGQGYADGLAGLLADGGLAAPEAAALAEEALRTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQH8</accession>
    <name>A0A0F4IQH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001375">
        <property type="protein sequence ID" value="KJY23738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23738">
        <property type="protein sequence ID" value="KJY23738"/>
        <property type="gene ID" value="VR44_37425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="38574" checksum="91A6B8A4ED617C9D" modified="2015-06-24" version="1" fragment="single">MTSPLLPAVTAEVTAEAVEALSARLRKKLDAAVEGCRDGAEAGADGSVVVAFGEDAVVTLRAAPSGVVTEAGQAVCSCLLAPRCLHRAAVLAASPVADPQPWPLPGEGEEDGGSAVTPAAESAAGTGPAAPSAAGPVPRRAGTGDTGAEPAGGAGASGAAAPSSGYTFGEPGPADRSGGVGTTGSTGQADPAGLRGEPGPGTGGGASGTGATGRTPGPAGPGGAAPGAGASGGAGVPSAAGAGGSGASAAGAMGGSGGPDRARGDAAGPGDGGAPAPTAAQVRAGAALWAVGAEALAAGVAAGGAVVQAELLRAAHTARVAGLPGAEAAALRVVRGLRAARERRAGERLADLAAAFEALLRTAALLAAGTGGPGLTGSGRRAYASGGSLKVHGLCREPVLTATGYGGVVTHLLGSDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR11</accession>
    <name>A0A0F4IR11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001331">
        <property type="protein sequence ID" value="KJY23918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952030.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001331.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23918">
        <property type="protein sequence ID" value="KJY23918"/>
        <property type="gene ID" value="VR44_36865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4686"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11108" checksum="43BA4B82389B4D85" modified="2015-06-24" version="1">MTKLGVSLKPGAYRGDAAISLATQGRGPVTIVVQWFLGGTQGAYSVPDGTDTIVVEAGAPATVVQSHTFTRGRGCYGGVRVTTKPAAANASASDSQLLMRCTDLEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRI9</accession>
    <name>A0A0F4IRI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001195">
        <property type="protein sequence ID" value="KJY24607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24607">
        <property type="protein sequence ID" value="KJY24607"/>
        <property type="gene ID" value="VR44_34865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11293" checksum="83B330F9AEDD31AC" modified="2015-06-24" version="1" fragment="single">LVLAASAPVPRRPAGWTAAAWAREVAAIRERGVAFDYEQCVDSLSCVAAPVHAADGQVVASVAVTSLDAKLIPPLCDAVSRAAAAIGARLARLPEPGRRPRASGPGGDRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRJ9</accession>
    <name>A0A0F4IRJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001193">
        <property type="protein sequence ID" value="KJY24617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24617">
        <property type="protein sequence ID" value="KJY24617"/>
        <property type="gene ID" value="VR44_34790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12554" checksum="0D9A3759412D1E25" modified="2015-06-24" version="1" fragment="single">MNDPQDPYDPYAAQQQLIGYDPYGRPLYGQAPAQQPLQPAPPPYGQQYETPYEQPYAQQSHAQQCDYEQQPQGGYAPQAPSYGYDARQQPQQWIPQQAAAPQAPGRPPAPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISV4</accession>
    <name>A0A0F4ISV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_33500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001124">
        <property type="protein sequence ID" value="KJY25077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001124.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5691"/>
    <dbReference type="EnsemblBacteria" id="KJY25077">
        <property type="protein sequence ID" value="KJY25077"/>
        <property type="gene ID" value="VR44_33500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3580"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="39583" checksum="140DC2AF89043DE6" modified="2015-06-24" version="1">MATETPSAAVPEQDAILDALATVNDPEIHRPITELGMVKSVEIGDGGAVAVTVYLTVSGCPMRETITKNVTDAVAKVAGVTSVAVSLDVMSDEQRKELAATLRGGTAEREVPFAKPGSLTRVYAVASGKGGVGKSSVTVNLAAAMAADGLKVGVVDADIYGHSVPRMLGVDGKPTQVENMIMPPSANGVKVISIGMFTPGNAPVVWRGPMLHRALQQFLADVFWGDLDVLLLDLPPGTGDIAISVAQLVPNAEILVVTTPQQAAAEVAERAGSIAVQTHQKIVGVVENMSGLPCPHCDEMVDVFGTGGGQLVADGLTKTTGATVPVLGQIPIDVRLREGGDNGKPVVLADPDSPAGAALRTIAGKLGGRARGLSGMSLGITPRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISY7</accession>
    <name>A0A0F4ISY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_37170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001353">
        <property type="protein sequence ID" value="KJY23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952087.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001353.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23821">
        <property type="protein sequence ID" value="KJY23821"/>
        <property type="gene ID" value="VR44_37170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4824"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="24853" checksum="7DFA845595B4DD03" modified="2015-06-24" version="1" fragment="single">MTGWSPRGHLVGSYGLPALAVLLFLVFSLALPDTFPTRDNVSSILSNQSIPALLALGATVPIATGKFDLSLGYGLGLAHVLVMYLVVETGTPWPAACLGVAAGGALAGAVNGIVVEFARIDSFIATLGTGSIMYALTGRLTDGSRIVPGPGGLPSSFTALYDGRFLGLPLPAFYVLAATVVLWVVLERLPFGRYLYVAGSNPRAAAVLGIPTRRYSVYAFATSGLLTGIAGVLLAAQQQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITK7</accession>
    <name>A0A0F4ITK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001088">
        <property type="protein sequence ID" value="KJY25347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25347">
        <property type="protein sequence ID" value="KJY25347"/>
        <property type="gene ID" value="VR44_32740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3360"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16177" checksum="234BA107F3BD18DB" modified="2015-06-24" version="1" fragment="single">MQAWRVHTTGEPREAMRLEEVPEPVPGEGEVRLRVLAANVNFPDALLTRGQYQIRPPLPFTPGVEVCGETEDGRRVLANPSLPHGGFAEYVTAPARALLPAPESLDDAEAAALHIGYQTGWFGLHRRARLQSGETLLVHAAAGGVGSAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU56</accession>
    <name>A0A0F4IU56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001267">
        <property type="protein sequence ID" value="KJY24221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951863.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001267.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2354"/>
    <dbReference type="EnsemblBacteria" id="KJY24221">
        <property type="protein sequence ID" value="KJY24221"/>
        <property type="gene ID" value="VR44_35990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4356"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="50925" checksum="7E34B1924232AACC" modified="2015-06-24" version="1">MAGGGGSAGGGGGFDLAALLAERGGERYELHARHLNHQLPRMLRTIGFDKVYVRAEGAHFWDAEGNDYLDMLAGFGVMGLGRHHPVVRRALHDVLDAQLADLTRFDCQPLPGLLAEKLLSHSPHLDRVFFGNSGTEAVETALKFARYATGRPRILYCDHAFHGLTTGSLSVNGEGGFRDGFAPLLPDTKIALGDLAALERELRRGDVAAFVVEPIQGKGVHAAPPGFLRAAQELLHRHKALLIADEVQTGLGRTGDFYAYLNEPGVEPDLVCVAKALSGGYVPVGATLGKDWIFQKVYSSMDRVLVHSASFGSNAQAMAAGLAVLHVMEEEKVVANARAMGDLLRGRLAALVDEYEMLHEVRGRGLMIGIEFGRPSSLGLRSRWTMLQAARKGLFAQMVVVPLLNRHRILTQVSGDHLEVIKLIPPLIVDEGDVDRFVGAFREVMDEAHGGGSLMWDFGRTLVKQAVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUE4</accession>
    <name>A0A0F4IUE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001044">
        <property type="protein sequence ID" value="KJY25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951129.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25627">
        <property type="protein sequence ID" value="KJY25627"/>
        <property type="gene ID" value="VR44_32000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3117"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="466" mass="49473" checksum="48A4A20EA9BFC748" modified="2015-06-24" version="1">MQPYELSIATAAEAIRARELSPLELVDSVLNRLEQVEPQLQAYVSVGADAARRAARDAERDVAAGRLRGPLHGVPMGLKDLIDVAGAPTTASSRVRTGHRAETDSTVAARLAAAGAVLLGKTHTHEFAYGLTTPQTHNAWDRGRVAGGSSGGSAVAVAAGAATFALGTDTGGSIRVPSALNGVVGLKPTYGLVPRHGVTSLSWSLDHVGPITRTVEDAALVLSSLVGHDPRDPASLTAPRPQYRPNGTTDLTGLRIGVPHNYYFDHVQPEVEAAVRLATAELEGLGAQLVEVEIPMTRYVQATQWGLMVPEATAYHERTLRAVPELYRDDVRILLEAGELMPAGDYLRAQRSRTLMRQAWARLLEDVDVIAAPTVPATAVKAHEETITWPDGTVEAVSDAYVRLSAPANITGMPSLSLPVGHDTAGLPIGMQLLGRPLGERELLRVGHAYEQTRPARPLATAQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUG5</accession>
    <name>A0A0F4IUG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001040">
        <property type="protein sequence ID" value="KJY25655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25655">
        <property type="protein sequence ID" value="KJY25655"/>
        <property type="gene ID" value="VR44_31915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="319"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="514"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144174" checksum="C8632A2C9B51EFBB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUL3</accession>
    <name>A0A0F4IUL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Curamycin polyketide synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001033">
        <property type="protein sequence ID" value="KJY25697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951095.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25697">
        <property type="protein sequence ID" value="KJY25697"/>
        <property type="gene ID" value="VR44_31820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3076"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9143" checksum="C5097D5DB25D1B8A" modified="2015-06-24" version="1">MSDRLTMEELAALMKSAGITVDPAELTSRPDSRFDDYGLDSLGLLGIVGELENRRGRALPTDADRCKSPREFVDLVNNSLMTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUS5</accession>
    <name>A0A0F4IUS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001027">
        <property type="protein sequence ID" value="KJY25762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951067.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001027.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4579"/>
    <dbReference type="EnsemblBacteria" id="KJY25762">
        <property type="protein sequence ID" value="KJY25762"/>
        <property type="gene ID" value="VR44_31680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3045"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19905" checksum="2DD9085FE7D392E2" modified="2015-06-24" version="1">MADTPDGTTPLHEPSLDEQIAVYQREFQDLDPQVEKVVSALSRLNRRMNVAYGRQTAALGISNAEWEVLKALVLSGAPYRMGPSELAKQLGLTPAAMTHRIDRMTAEGLVTRERDESNRVRVIVELTDEGRSKWLDAMRAATVFEEDLLQDLSTAERGVLGDMLIRVLDRVEDLQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUS7</accession>
    <name>A0A0F4IUS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001231">
        <property type="protein sequence ID" value="KJY24416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951760.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001231.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5704"/>
    <dbReference type="EnsemblBacteria" id="KJY24416">
        <property type="protein sequence ID" value="KJY24416"/>
        <property type="gene ID" value="VR44_35445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4203"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="26580" checksum="6AE2516654CD28B4" modified="2015-06-24" version="1">MSTVENASPADENAPAGAQGIAAQDWATASASPQYRAAVVDLLGALAYGELAAFERLAEDAKLAPTLGDKAELAKMASAEFHHFERLRDRLAAIDAEPTAAMEPFAKGVDDFHRQTAPSDWLEGLVKAYVGDSIASDFYREVATHLDSDTRALVVGVLDDTGHGGFAVEKVRAAIEADPRVGGRLALWARRLMGEALSQAQRVVAERDALSTMLVGGVDGMAAGFDLAAVGEMFTRITKAHTKRMAALGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUW3</accession>
    <name>A0A0F4IUW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001022">
        <property type="protein sequence ID" value="KJY25807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25807">
        <property type="protein sequence ID" value="KJY25807"/>
        <property type="gene ID" value="VR44_31575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2811"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="28501" checksum="DED8F4F95F0DEA8C" modified="2015-06-24" version="1">MTDRHAQGSGPRARCVGGSGEVRSDVLSSLFSRGAGRDPRHLGELAVELGIPVADLLVVAGRPVPAELLPPGRDAKVMKQFAHRVSHCDHSQLAALVDFTGSLPRPAAPEPFVEPRWPGKNRPPETRLAALLCALLRNRGFGIGELPFLGLSLSTLRSMVWRCDPSPHRQQQLAALAGPLGWTLPDLFAVAGEPYPEGLRPVVHCHHLGQLFTAAVPLTTAQLIETAREADRLSLREDRGTWQPVSEGFAEQCPDRSEELPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV01</accession>
    <name>A0A0F4IV01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001017">
        <property type="protein sequence ID" value="KJY25860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951015.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25860">
        <property type="protein sequence ID" value="KJY25860"/>
        <property type="gene ID" value="VR44_31405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2771"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18866" checksum="25264F0484D0D581" modified="2015-06-24" version="1">MPTAQECIAARGLEPHVEGGYFRRTFQADHRPPTTTPAGDRFTLTSIHYLLTHWSPVGHWHLNRSDILHFHHHGDPITYHLLHPDGRYETAVLGQDAGRGEVLTLAVPGGVWKASHLTAGDHGLISEAVAPGFDFADMTLGRPDELVALFPDHEDLVRRYCRPEGPDSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV28</accession>
    <name>A0A0F4IV28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001014">
        <property type="protein sequence ID" value="KJY25885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951003.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25885">
        <property type="protein sequence ID" value="KJY25885"/>
        <property type="gene ID" value="VR44_31345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2758"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12085" checksum="7626D7733E77D8D5" modified="2015-06-24" version="1">MVMPGTEDERFSVAVRTVDGAVLLTLGGELDHDTAEPLRQALAAAAGRGGRLVVDMSGLRFCDSTGLNALLHGRIAIEDAGGSLELAGLGGPVARMFRITGADSVFPVHEDVEQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVG1</accession>
    <name>A0A0F4IVG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000995">
        <property type="protein sequence ID" value="KJY26015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950953.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000995.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26015">
        <property type="protein sequence ID" value="KJY26015"/>
        <property type="gene ID" value="VR44_31050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2663"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27714" checksum="CA6368544B987FCC" modified="2015-06-24" version="1">MALLPDITAFYGAGDEAARLTSGRTIGTVELVRTQELLRAHLPPSPASVLDVGGGPGVHARWLTESGYQVLVVDPVQEHVRQARHQGLAAFVGDARQLDQADVSFDAVLMLGPLYHLPDGAGRSRAWREAHRVVKPGGLVAAAALNRYAKLLELGSPTALDIATTGLRVRRDGPTTYYHAPSELCAEARQAGFDEPTVYGLHGPAYEALRAEERRTGTKDLGARALETALAAARFADSHPELVVSSLHLLAVVRRPCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVI5</accession>
    <name>A0A0F4IVI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_31905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001040">
        <property type="protein sequence ID" value="KJY25654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951112.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25654">
        <property type="protein sequence ID" value="KJY25654"/>
        <property type="gene ID" value="VR44_31905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3096"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="27731" checksum="91F0C4FA43C07C0B" modified="2015-06-24" version="1">MAVQLRLLGVRPRQRLLVHAALGGTGLHPGTLREALSGVLGPHGTLVVPAFTPENSLTSSAHLERTAGLDSEALAAFRARMPAFDPERTPSQGMGALAEAVRTAPGAARSGHPQTSFAALGADARRICAEHRLECHLGEDSPLGKLCWEGGQVLMINVGFASCTAFHLAEYRIPKPPLRMYDCVVKVNLPGERRGTAHEGEWTRYEDVALDDSDFAEIGRAFPDSLLRRGKVGGAPAVLFSITDAVDHAQAWMTENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVK6</accession>
    <name>A0A0F4IVK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001037">
        <property type="protein sequence ID" value="KJY25674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951105.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25674">
        <property type="protein sequence ID" value="KJY25674"/>
        <property type="gene ID" value="VR44_31870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3088"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470452" evidence="1">
        <location>
            <begin position="27"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="35714" checksum="7A48512978E8C402" modified="2015-06-24" version="1">MFAHRRKAWGISLAAVAVGLATSAAAWPGAPAAGAPGADCAGARAGIERLEGRITPNVCAFLQRQLAFGGMPTGDAPLTGDKALQHPRVAAYLDIFDPAATLWEAGSAPRTGQPVIGAAIAGSLRLAPDLRYTGTNVVADGGVVMFGQWNTATVKGHKVAYPQIARNVLGDEGRTLQARRYYDRHVLVRDILPDAPEGLFDGARLTPADLPDRLAAWNAGDAGALLSRTGGARLAGPGLAAPLVTKAGKRDYLQRLLDRADLELKAGQVAFGKTTTYVEWYGTVSRKRATPNGEDGPAVPFGIVERFGPDGEWELYFDTLPVLADQDTINGLLTRLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVM4</accession>
    <name>A0A0F4IVM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein in whiE locus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001034">
        <property type="protein sequence ID" value="KJY25689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951099.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25689">
        <property type="protein sequence ID" value="KJY25689"/>
        <property type="gene ID" value="VR44_31840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3080"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007575">
        <property type="entry name" value="SchA_CurD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04486">
        <property type="entry name" value="SchA_CurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="39904" checksum="E2F639820ABBB7D4" modified="2015-06-24" version="1">MTTTLSERVSQSAFDGSMLRVVLLMDLHEGAQQRFFEAYERLRHDIASVPGHLGDQLCQSFENPSQWLITSEWESAPQYLAWVNSEEHAEQVKPLGACARSMRPLKFTVLRETGRRYDFPQAGFGGRLQDGPRLGEGIVRHALTFTVKPGSEGKVAEILSSYESPAARVDDHTRLLRTSLFMHGNRVVRAVEVQGDLTAALRHVSEQPEVRAVEHAINPYLEQDRDLSDPESARMFFMRAGLPAVHHVAAHGPQPDRITRHALFYPAKPGCGPLVARFLARQDEAAAKIPTSPVLSSSIFQRDDVVVRLLDVTGPADGRFAGGFGMESPRKAAVLDRLLAGAPQAPYPMDLITDRRAPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW77</accession>
    <name>A0A0F4IW77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_30450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000960">
        <property type="protein sequence ID" value="KJY26272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950843.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000960.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5347"/>
    <dbReference type="EnsemblBacteria" id="KJY26272">
        <property type="protein sequence ID" value="KJY26272"/>
        <property type="gene ID" value="VR44_30450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2504"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY26272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="36212" checksum="CA908A79E912F86B" modified="2015-06-24" version="1">MTIRVGINGFGRIGRNYFRALLEQGADIEVVGVNDLTDNGTLVHLLKYDSILGRLKQDVSHTDDTITVGDMTFKTFAERDPANLPWGELGADIVIESTGIFTKKADAAKHIAAGAKKVLISAPAKDEDITIVMGVNQDKYDAANHHVISNASCTTNCVAPMAKVLDENFGIVKGMMTTVHAYTNDQRILDFPHSDLRRARAAAENIIPTSTGAAKATALVLPQLKGKLDGIAMRVPVPTGSVTDLVLELSRETTKEEINAAFQKAAEGQLKGILDYTEDAIVSSDIVNWPASCTFDSSLTMVQDGTQVKVVGWYDNEWGYSNRLVDLTVFVGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWH0</accession>
    <name>A0A0F4IWH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001004">
        <property type="protein sequence ID" value="KJY25959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25959">
        <property type="protein sequence ID" value="KJY25959"/>
        <property type="gene ID" value="VR44_31145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13185" checksum="3C1508672DE4DEB3" modified="2015-06-24" version="1">MTATPCTSLFDCCVRRTGRKKPGLVVDLGGTDAVSKPLGIPLRGLPAQAVARGYHWSALRTNVAKTRVLTNWLLNAVAGDDFVRMGLREGRPPTLREFEHGDDYLTPEQVRARTAAPRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXE4</accession>
    <name>A0A0F4IXE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMPACT family member yvyE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000953">
        <property type="protein sequence ID" value="KJY26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950814.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000953.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26324">
        <property type="protein sequence ID" value="KJY26324"/>
        <property type="gene ID" value="VR44_30285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2467"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22465" checksum="93281716CD803809" modified="2015-06-24" version="1">MKADQYETVAREGSHESEINRSRFLCSLAPAATEQEAQDFIARIRREHPTATHNCFAYVIGADASIQKASDDGEPGGTAGVPMLQMLTRRDIRYAVAVVTRYYGGVKLGAGGLIRAYGGVVGEALDALGTVTRHRYRLATVTVDHQRAGKTQNDLRSTGRAVLDVRYGEAVSIEIGLPEADVESFRAWLNDVTAGTAGFELGGEAYGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXZ7</accession>
    <name>A0A0F4IXZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_29880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000930">
        <property type="protein sequence ID" value="KJY26519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26519">
        <property type="protein sequence ID" value="KJY26519"/>
        <property type="gene ID" value="VR44_29880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2356"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470550" description="TED domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="4">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="38363" checksum="DE08CD4768F08788" modified="2015-06-24" version="1">MAVALLAAALTAAPGARASADSDQAVSSAAAGGASAVLDGLKTYGQAVLHARDGSVRQIPAGLYEMRVDGGGMLQTYGVGVAGNAQPQARYTESGWGGSPLAANGEAGGRIRWVLEHSYPQHNDLAGLAKAAGAGALTAESAAAGTQVAIWRLAEGAQVEATDQAAEKLADYLQREAGRLPEPPASLRLDPGRVTGSVTGPTGTRLGPVTVRTGAQSVSVTPDAAAVAMGVRVVDADGQPVTSAADGSRLYFEVPPGTPDGTASVTVQGSTKVPVGRVFTSGIPDEAQVVAGSSESAAAATATAVWPQPPAGPAGKVGTLAGSAEVVPAAPAGTETQSPDEERLAVSGSSAATPVIASLAVGLVVLGGMVVLLLRKRPLEGEEGEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY36</accession>
    <name>A0A0F4IY36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000945">
        <property type="protein sequence ID" value="KJY26388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950792.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000945.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26388">
        <property type="protein sequence ID" value="KJY26388"/>
        <property type="gene ID" value="VR44_30165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2438"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="473" mass="51448" checksum="43FEC6490AC774CC" modified="2015-06-24" version="1">MTTTAPTTTAHRSGRRFEAARQVADAVLFEGYVLYPYRASAAKNRMRWQFGVLVPPAWAPAQGEHSLQRTEVLMEPRGAATLSLELRFLHAQRRTVQRALDDGSFTDTDALHLPDRVLVPWDEGTEERVELRVAVPELTQKEIVLPFTRPAREDTEAVLDDRGRTVGRLVRRTQEVEGVVRLRAEELDGPYRVLKLTAVVENTSPWTPAEPAAAREEALPRSLVAAHLLLGLTPGSFLSMTDPPEWARPAVAACANLHTWPVLAGEDGRADVVLSSPIILEDHPAIAPESAGAMYDATEIDEILALRTAALTDEEKREARGTDPRAAAVVDLADSLPPEVLERLHGAVRSLRGATGESLPAAPSPDALFTPDTPWWDPAGAGAEEPGPGRVTVDGTAVGPGSRVRLRPGLRRTDAQDLFLQGRAARVEAVLHDVDGGVHLAVTVEGDPGADIRREQGRFLYFQPDEVTPLEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYG1</accession>
    <name>A0A0F4IYG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000874">
        <property type="protein sequence ID" value="KJY27065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27065">
        <property type="protein sequence ID" value="KJY27065"/>
        <property type="gene ID" value="VR44_28470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2020"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11350" checksum="DE5E3DB8EFE93192" modified="2015-06-24" version="1" fragment="single">AAGRAARLADPAARVGTRGQVLTVADYLSAYVLEWTLHHLDLIAHLPSAPPPPADTLAAARTALERIAGAPFPASLTDGDALLVGTGRRAPTAAERTDLGALASRLPLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ80</accession>
    <name>A0A0F4IZ80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001003">
        <property type="protein sequence ID" value="KJY25966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950967.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25966">
        <property type="protein sequence ID" value="KJY25966"/>
        <property type="gene ID" value="VR44_31140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2715"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045728">
        <property type="entry name" value="DUF6082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19560">
        <property type="entry name" value="DUF6082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470261" evidence="2">
        <location>
            <begin position="30"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="22268" checksum="E16376FF0E8AAB6E" modified="2015-06-24" version="1">MAYSLLGLGLLGLIVSTPFLLSAVAPASADWGRLSDISQTYGAVSVVLSALALAGVALSLLYQVRQARTNNEQAIRDSHLQLATLALSDPNLLLAWSPPVAPVTFKRHQQHLITSLALGELLQRFRIGHLSIEKLTVKLDGHFRGESAREQWEREGSGWRRTMEAGDRRDRVFVRLVDESYRTAVAAGPASALLEFQDRPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ84</accession>
    <name>A0A0F4IZ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001002">
        <property type="protein sequence ID" value="KJY25971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25971">
        <property type="protein sequence ID" value="KJY25971"/>
        <property type="gene ID" value="VR44_31115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12855" checksum="216F4E6F279EB95F" modified="2015-06-24" version="1">MTTTGDLVAELDDVRRILDRRPGDLRHVNQPFDATGYLDEGPEGNQLGDGSRQPLPRLRGIGEHLEQVGLWVAFKDSRASQSQVSHWRNSHRRRCPTWTMAVPVSQRCRDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1T0</accession>
    <name>A0A0F4J1T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950587.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26866">
        <property type="protein sequence ID" value="KJY26866"/>
        <property type="gene ID" value="VR44_29070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2147"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="29169" checksum="446706D0FEBFB724" modified="2015-06-24" version="1">MVRIRVLVVDDHRIFAESLAAALAAEPDVDVSAAGSGPAAQRCLERAAAEGRRFDVLLVDADLGAAGAPAPPAVPGAAGPPGTPGPPGTAAGAGMGAVLPVPGQRAPGAPSPPPADGIALVAGVRTAHPGVRTVVLAERDDPRRAALALQAGASGWVAKDCSLSRLLAVIRGVLREETHLAPALLTGVLRELTAARKHRTDSERLVESLTPREHEVLRCMVAGLGRKDVAARLFLSPHTVRTHMQNVLGKLGVHSTLAAVAMARRAGVRPAELSGDVVERSGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J223</accession>
    <name>A0A0F4J223_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000738">
        <property type="protein sequence ID" value="KJY28357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3634"/>
    <dbReference type="EnsemblBacteria" id="KJY28357">
        <property type="protein sequence ID" value="KJY28357"/>
        <property type="gene ID" value="VR44_25530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="13163" checksum="D2EB2CAB689840C6" modified="2015-06-24" version="1" fragment="single">MKDILDAIQSQSATAADFAALPLPDSYRAITVHKDETEMFDGLASRDKDPRKSLHLDQVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLSTFGFLERYGRLSELTKRHDLPYHVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J243</accession>
    <name>A0A0F4J243_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949932.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28382">
        <property type="protein sequence ID" value="KJY28382"/>
        <property type="gene ID" value="VR44_25490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470321" evidence="1">
        <location>
            <begin position="35"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="29327" checksum="DD1F4B879843AACD" modified="2015-06-24" version="1">MVVHQHRRRRRRAGEAVLAVCVAVTVAALGGCGAASGTVAGGGAGDARPPGDPAAAVRGAADALAATGSAQARTAMEMATGGTRVTIRGEGGVDFRKGMGQLLVMLPADVKGQPEHRPITELLVPGALYMKNRGAGVPDDKWVRLDTAALPDGNLVTGGATDPLAAAELLRGAQEVTYVGETDVAGTKVRHYRGTTDIGRAAQNASAGVREALRAAAKGFSKDSVPFDAYLDEEGRLRKVRHRFTYVKNGVIDVSSTTLLYGFGTPVTVVLPAEGDIYAGKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2G4</accession>
    <name>A0A0F4J2G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="2">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_25245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000726">
        <property type="protein sequence ID" value="KJY28487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949885.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000726.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28487">
        <property type="protein sequence ID" value="KJY28487"/>
        <property type="gene ID" value="VR44_25245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1144"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="49327" checksum="687EB677183C09D0" modified="2015-06-24" version="1">MHDVTPGDSAHSTHTFTAAEFEAFAAVTGDHNPIHHDAGHAAGTEFGAPIVPLVMTLGPVSALIGMVLPGPGAVILGTEFRPVRAVAFDRPVHYSLRVLSVSPATGVFTCRVLAYQDREAVLEGEVRTTVRAPRPRPDATTGGRLVPAGARPTAVVTGAAGDIGSAVARTLAARGWDLALVHRGGAEDLVRDCERAGARVHPVTADLADPAAREAAAAKLAALEPAALVHAAAAPLAAGYREHLDVGYAALRDLADAVLDGMLLRQRGCFVLIGSEAVRYHPRGWSDYVAGKAAAESVLHGIDRHHGAHGIRSVVVEPGYVQGSYSAGVRPAGLGLLPEEVADLVAAEVADTEAPARRLWLTPDGVARFALDGRREDAPPAPRTASAAPAGAAETGTGRDTAPGAAADRVEAAVRTVLGPAADVRGGGVGLTAGWDSLAQLQIVLAVEAEFGLRLPAASLSGAGRFDQLCRIVEERTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3M2</accession>
    <name>A0A0F4J3M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydroxybenzoyl adenylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000741">
        <property type="protein sequence ID" value="KJY28313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28313">
        <property type="protein sequence ID" value="KJY28313"/>
        <property type="gene ID" value="VR44_25605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1220"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="425" mass="45070" checksum="A796E029F00B4F30" modified="2015-06-24" version="1">MTSMLDGCTPWPEEFVDHYWAAGHWQGNTLDTLLRGWALQYGPRTALVHGGTRLTYAQLNRRADRMAAGFRGRGLRPGMRVVVQLPNVPEFVVTAFALMRAGLVPVFCPVSHREPEVPELVRLTQAVGYVGPSTHEGFDHTAMAARIAARWPFLRRVFTYETPGTESPYGGLTTDPSNCQYAPLASLDAPPEPALPLSAGQVAFLLLSGTGGLVPRTHDDYAHQVTAAAELLSLTEEDVYLAALPVEADLALGGPGVIGTLSAGGTVVLTDGPDPAVCLPALARERVTVTTLTAGTARRWLDALPLPGAAPRLVQICGAPPERETAERIGAALNCRVQLAFGLPEGVLTLTRPDGSAPTTHGRPLSPGDQIRLVDATGAPVPDGATGELQTRGPHTIRGYYHAPDRDACSFTSPDGDLVVTGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Y1</accession>
    <name>A0A0F4J3Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxic anion resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000687">
        <property type="protein sequence ID" value="KJY28975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949662.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000687.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28975">
        <property type="protein sequence ID" value="KJY28975"/>
        <property type="gene ID" value="VR44_24040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.800"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32703" checksum="1390BEAB1F5050F5" modified="2015-06-24" version="1" fragment="single">AVRSIGADGGGAAQARVAGSLVELRRTVEDLDPQAGAPVKGARRLLAKLPGGNRLRDHVARYASAQDTLNRIVQALLGGQDELRRDNAALHTERARLWETMGKLQEYAVLTEALDAAVEQRIGEAERTDPGQADALRSDVLFPVRQKHQDLLTQLAVCAQGYLAMDVVRRNNDELIKGVDRAATTTVSALRIAVMLASALDSQRKVIEQVNNLRGTTESLIRGNAEMLAGQSGEIQRIAADPAVGAETLRTAFGQIYKTLDAIDSFKVQAAENMAATVESLTGELQAASAYLARTRTPSALEGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Z1</accession>
    <name>A0A0F4J3Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_25135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000722">
        <property type="protein sequence ID" value="KJY28529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949865.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000722.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28529">
        <property type="protein sequence ID" value="KJY28529"/>
        <property type="gene ID" value="VR44_25135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1119"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23231" checksum="7C63E9416BBC2814" modified="2015-06-24" version="1">MTEAVAQEEQLKVVVADDQAAVREPLAAVLALAEGIEVVAAAANGTEVLAAVAAGPVDVVLMDLRMPVMDGIETTRRLAGEYPDVAVVVLTTFADDDSILGALGAGARGYLTKNAGRQDITRAIRAAAAGQSVLDREVQDRLLATARTHAPPAYRPLPEDLTPREREVLALIGEGLPNRGIAERLFISEATVKTHINNLFAKAGIRDRADAVRRAIAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J430</accession>
    <name>A0A0F4J430_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000718">
        <property type="protein sequence ID" value="KJY28569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28569">
        <property type="protein sequence ID" value="KJY28569"/>
        <property type="gene ID" value="VR44_25040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16335" checksum="D649503FB0CE5EC0" modified="2015-06-24" version="1" fragment="single">TYVRHRGGPPGIWFFSLDVTQPLLLAARLLGLPYHLAKLTIGPDGANCRYTGSRKPTGPSYDITVRTSRTPTAGPLDEWLTDRFHSYSTRAGILWRTPVRHEPWPLLQATTVSATQTLTRAAGLPEPSEQPLTHTSPGVGPVTFGPARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Y9</accession>
    <name>A0A0F4J4Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000654">
        <property type="protein sequence ID" value="KJY29325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949515.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000654.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29325">
        <property type="protein sequence ID" value="KJY29325"/>
        <property type="gene ID" value="VR44_23245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.589"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21702" checksum="F040435B86A34DC6" modified="2015-06-24" version="1">MGKTYERIDGRLREFIERQPVFFTATAPLSGDGTVNLSPKGLSGSFAVLDEQRIAYLDFAGSTAETIAHLRENGRITVMWCAFQGPPNIVRVHGRGEPVFRDDPRFKELLAHFPDIDPTLHGLRAIIVVTAELVRDSCGYGVPFMSYDEDRDLHGKRFAREDDASLGEYFAKKEHIAQSIDGLPGLPLPLPPSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5R7</accession>
    <name>A0A0F4J5R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949600.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29108">
        <property type="protein sequence ID" value="KJY29108"/>
        <property type="gene ID" value="VR44_23700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.686"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10065" checksum="D4942FB764CE39A8" modified="2015-06-24" version="1">MTAAPPPVPDRYTVVLRPGPPGVQDAKGHAAVLRTARVEATGATGVSGYPCFEGEGVQAEIDPESRAVEAVTVDGEELPYGWIAQLADDDPRPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J620</accession>
    <name>A0A0F4J620_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_23480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000663">
        <property type="protein sequence ID" value="KJY29213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949561.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000663.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29213">
        <property type="protein sequence ID" value="KJY29213"/>
        <property type="gene ID" value="VR44_23480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.638"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="10"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="517" mass="55606" checksum="975D8F18E3CB53FC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J630</accession>
    <name>A0A0F4J630_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949931.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28381">
        <property type="protein sequence ID" value="KJY28381"/>
        <property type="gene ID" value="VR44_25485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1194"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11741" checksum="968C785B4929021D" modified="2015-06-24" version="1">MTTIEAEGSGAVPVHGYHHQKDEHLKRLRRIEGQIRGLQRLVDEDVYCIDILTQVSASTKALQSFALQLLEEHLRHCVADAAVKGGTEIDAKVEEATKAIGRLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6B6</accession>
    <name>A0A0F4J6B6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">VR44_23280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000655">
        <property type="protein sequence ID" value="KJY29318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000655.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3045"/>
    <dbReference type="EnsemblBacteria" id="KJY29318">
        <property type="protein sequence ID" value="KJY29318"/>
        <property type="gene ID" value="VR44_23280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.596"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="37624" checksum="98A63424319AFC14" modified="2015-06-24" version="1">MGKTALITGVTGQDGSYLSELLLSKGYTVHGLVRRSSSFNTERIDHIYQDPQTANRSFVLHHADLSDGVALVNLLRDIRPDEVYNLGAQSHVRVSFDAPLYTGDVTGLGALRLLEAIRASGVDTRIYQASSSEMYGSTPPPQNEDTPFHPRSPYGAAKVFAYWTTVNYREAYDMFAVNGILFNHESPRRGETFVTRKITRAVARIKAGLQDHLYLGNLDAVRDWGYAPEYVEAMWRMLQQDEPTDYVVATGVAATVREFVESSFAHAGLDWNEHVRYDPKYERPSEVDALIGDASKAQEILGWKPTVLVPELARIMVDADVRQVEDQLAGATVRIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J716</accession>
    <name>A0A0F4J716_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_22565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949396.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29563">
        <property type="protein sequence ID" value="KJY29563"/>
        <property type="gene ID" value="VR44_22565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.403"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="65"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="21360" checksum="92046214076806AA" modified="2015-06-24" version="1">MSTNTLDTTVPEWSHRERAAASAKLMLGWVALLWLIELIDLAAGHALDLYGIRPREADGLIGIPLAPFLHFGFGHVAGNSLPLLVLGFVTALSGIRRFLAVCLLVIAADGLGVWLISPAHSVTIGASGLIYGLFGFLLVRGFVERKVLGIAVGIAVAAYYGGGMFLGLLPLNPLVSWQAHLCGLAAGVATALWYRRPAPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7F4</accession>
    <name>A0A0F4J7F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949715.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28886">
        <property type="protein sequence ID" value="KJY28886"/>
        <property type="gene ID" value="VR44_24295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.840"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="22682" checksum="DEB2B9461C292DCB" modified="2015-06-24" version="1">MEEGQLDAQAWSEALTLYKWLCTFVGVAPREHDEWWLDVGAIMRLETQDPRGWESIDPYEGEEERLEDPLFPWLETPSTTVDAERYRRRVDEIPRSSVRSLIVLLGAGTSRLDLSKSLGWEERRPEMERRAGVILSRFPDGTRFYTNLGWKSDHPEFYEQPFRTHAPFSQYDWDAGLIAVNDDEVAVLWNFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J896</accession>
    <name>A0A0F4J896_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000666">
        <property type="protein sequence ID" value="KJY29176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949573.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000666.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29176">
        <property type="protein sequence ID" value="KJY29176"/>
        <property type="gene ID" value="VR44_23555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.656"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="19912" checksum="B8A3FEE3CA91131E" modified="2015-06-24" version="1">MAVSLPELTGDYVLDPAHTRIGFVARHAMVTKVRGAFHEFEGTAHLDGADPSKSTGQVVIKTQSIDTGVEQRDQHLRTNDFLDAPSFPDITFRATEVERKSDTEYRVTGDLTVKDVTKPVTIDFEYTGNAVDPYGNLRVGLEGSATISRKEFGVTWNAALEGGGVLVGDKIVLEFDLSAIKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9H3</accession>
    <name>A0A0F4J9H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000629">
        <property type="protein sequence ID" value="KJY29621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29621">
        <property type="protein sequence ID" value="KJY29621"/>
        <property type="gene ID" value="VR44_22465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.382"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="159"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="280"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="43270" checksum="3986D8AE9F62AEE0" modified="2015-06-24" version="1">MTGRAAPVDRPLDRAKLLAARYSAAEARPYLASALYALTVVPSPGPAGVTTMGVDRHWRCYVSPGFVDRTPVPELAGVWIHEVAHLLRDHHGRADRLPAADQRDPLRINIAQDCEINDDLLADGLRLPEGRMEPGRFGLPTGGLFEGYLPAIPHTPPHQHVDCGSGAHGVPAPWELGGGEGTARIGPVEAEALRRTTAQAVRAHRRTRGRGSVPAGWERWAEQVLEPVVDWRRALTGAVREAAAWAGGAVDYTYRRPSRRTPALGGRVVLPSLRRPLPRVAIVVDTSGSMGDEELAAALGEVTGVLREVGVGGNRVAVLACDADVQAVNRVTSAQQVTLAGGGGTDMRVGIAAALDVPDRPNVVVVLTDGYTPWPDGSLPCRVIAALIGPDAPQPPDWVETVRVPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAY3</accession>
    <name>A0A0F4JAY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ORF">VR44_19220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948775.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5440"/>
    <dbReference type="EnsemblBacteria" id="KJY30944">
        <property type="protein sequence ID" value="KJY30944"/>
        <property type="gene ID" value="VR44_19220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8450"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="11"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="44116" checksum="86ECB7AA1F55448E" modified="2015-06-24" version="1">MTAHRQPALLATDPELASLVTAEETLQARTLRLIPSENYVSAAVLEASGTVLQNKYSEGYPGRRYYEGQQNIDRVEALAIERAKGLFGVDHANVQPYSGSPANLAVYLAFAKPGDTVMGMALPMGGHLTHGWGVSATGSWFRGVQYGVRAEDGLIDYDAVRELALAERPKILFCGGTALPRTIDFEAFASIAAEAGSVLVADVAHIAGLIAGGAHPSPVPYADVVSTTTHKTLRGPRGAMLMCKEEHAKAIDKAVFPGLQGGPHNQTTAGIAVALHEAAQPSFTAYAHAVVANAKALAAALLERGFDLVSGGTDNHLILMDLTSRGVPGKVAAKALDRAGIVVNYNTVPFDPRKPFDPSGIRIGTPSLTSRGLSVDHMPAVADWISRAVDAAAKGDEPALAVIRAEVSDLLAAFPAPGLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBM8</accession>
    <name>A0A0F4JBM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000481">
        <property type="protein sequence ID" value="KJY31595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948504.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000481.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31595">
        <property type="protein sequence ID" value="KJY31595"/>
        <property type="gene ID" value="VR44_17805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8104"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="44899" checksum="996982CC04E0A979" modified="2015-06-24" version="1">MALGSEMVDLLELSPDFVRDPYPVYAQLRERGPVHHVRTPDGEQVWLVVGHEACRAAFTDPRLSRDWRRSGDIGQIINTEQDDPSLAHMLMSDPPDHTRLRRLVAREFTPRRIEALAPRVQQITDELLDAMEANGDRRADLVDAFAFPLPMTVICELLGVPELDRESFRNWSNEMTARTSPEAQAAAYEAMPRYLTSLIDAKRTEPGDDLLSAMIHAVDEGGDRLSPSELIGMCVLLLIAGHETTVNMIGNGMRALFAHPDQLADLRADLGLLDGAIEEMLRYDGPVETCTERLVLEDVEMGGVVVPKGSVVLIAMADADRDPDRFKEPDRFDIRRDARGHIAFGHGLHYCLGAPLARLEGRIALRSLLERFPDLAVDAEEAELPWIPGMLIRGVKKLPVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCV6</accession>
    <name>A0A0F4JCV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000478">
        <property type="protein sequence ID" value="KJY31644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948486.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000478.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31644">
        <property type="protein sequence ID" value="KJY31644"/>
        <property type="gene ID" value="VR44_17710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8038"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="12364" checksum="57B0F4A8DCF8E8DF" modified="2015-06-24" version="1">MEKTAKQQARQAVTDLELRFIEAVEHGRLRAELTYEQLGRYLGMSKSQISKRQDGQITYTLRDMHHISRLLGIDPLVMAAGLGAWLNDIQPTEVHHRLNALTNANPGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE74</accession>
    <name>A0A0F4JE74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7326"/>
    <dbReference type="EnsemblBacteria" id="KJY32490">
        <property type="protein sequence ID" value="KJY32490"/>
        <property type="gene ID" value="VR44_15895"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="10273" checksum="6581643B8E5305F7" modified="2015-06-24" version="1" fragment="single">MDSAEYERKIASRFATFDQDGSGYIDREDFSTAARAVLAEFGVTARSDKGQALFAGAEAFWQGMAGIADVDGDQRVSREEFVTGAAKRLRDNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE93</accession>
    <name>A0A0F4JE93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000399">
        <property type="protein sequence ID" value="KJY32672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948067.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000399.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32672">
        <property type="protein sequence ID" value="KJY32672"/>
        <property type="gene ID" value="VR44_15475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7496"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="181"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="31722" checksum="61001AD3E81EE8C1" modified="2015-06-24" version="1">MPAASPSPATTPATATTPTAPAQARTTSPANRLKGGLGGRFGPVALVVAAGISVQFGAALAVMIMPRAGAAGVVTLRLAAAALVLLAVCRPKVRGYSRADWGTVVAFGVAMAGMNGLFYQSIDRIPLGPAVTLEVLGPLALSVLVSRRLVNLLWAGLALGGVVLLSGHGGGGLGFGSLDPLGAAFAVGAGAMWAAYIVFSARTGRRFPQADGLALAMAVAAVISLPLGVAQAGSALLVPSTLALGLGVAVLSSVLPYTLELLALRRLPAPTFAILMSLEPAIAATAGFLVLHQAMSLLDALAIALVIAASMGAVRAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEQ8</accession>
    <name>A0A0F4JEQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948055.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32685">
        <property type="protein sequence ID" value="KJY32685"/>
        <property type="gene ID" value="VR44_15425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7486"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="18743" checksum="B2A57A4B20522270" modified="2015-06-24" version="1">MDLRSEPELIEELRPLLSAEAAAEAPAAGVDAADLEQAVWVRLLEQGPPGPAPAGRARWLRRAVRAEARLARRHTRREVPYGAAPAATADEPEDALLHGEENRALRSAVARLPGRCPELIAALLSPRDLTYREIAGELGISQGSLGPVRSRCLGCLRRMLAAEVAAPGLWGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFM1</accession>
    <name>A0A0F4JFM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948100.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000072_gene306"/>
    <dbReference type="EnsemblBacteria" id="KJY32599">
        <property type="protein sequence ID" value="KJY32599"/>
        <property type="gene ID" value="VR44_15655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7532"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19352">
        <property type="entry name" value="TetR_C_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23438" checksum="3C1C0B6A1BFF32E9" modified="2015-06-24" version="1">MTGQVRTVDGRVAGRRGQATRQKLLDCLSEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAEEMATEGAQLTALVEGRNWVGKAGWAAAEELVDGFLDFWRRNDAILRVVDLGAAEGDKRFYKIRMKILNSVTNSLTESMKELQAKGKVDKDLSPAAMAGSLVAMLAAVASHQKGFQTWGVKQAELRPNLALLVHLGVTGKKPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGL7</accession>
    <name>A0A0F4JGL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_16545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948271.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32111">
        <property type="protein sequence ID" value="KJY32111"/>
        <property type="gene ID" value="VR44_16545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7741"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="21905" checksum="ADDF358139D69D75" modified="2015-06-24" version="1">MDSATSDPGAPRQALSSTADNGLKIVIVGGFGVGKTTMVRSVSEIRPLNTEETMTQAGEAVDHTDGVAAKTSTTVAFDFGRITLDARNVLYLFGAPGQERFWFLWDRLFSGTLGAVVLVDTRRLADSWYAIDRLEHHGTPFVVACNDFGGPAHTPEQIRAALDLPSEVPLLFCDARSRESSKQVLISLVQHLQHLSSLQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGT0</accession>
    <name>A0A0F4JGT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000433">
        <property type="protein sequence ID" value="KJY32186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948251.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000433.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32186">
        <property type="protein sequence ID" value="KJY32186"/>
        <property type="gene ID" value="VR44_16440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7685"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18614" checksum="55D1F8B7DC004BF1" modified="2015-06-24" version="1">MRPRSLRELSAAGPNVLATERFVLRELTADQVAALLRDDVPGDDAAPGYPTAGSRAAATAFGRRTADQHPRGFGMYQVVRCADGRVIGDIGFHAPPHEGSVEVGFGLVESGRGAGYATGALQELTRWALDQPGVTTVVARSAKDNAASQAVLERAGFHRRAEEADLFHYACVRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGZ5</accession>
    <name>A0A0F4JGZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000425">
        <property type="protein sequence ID" value="KJY32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948226.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000425.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6886"/>
    <dbReference type="EnsemblBacteria" id="KJY32251">
        <property type="protein sequence ID" value="KJY32251"/>
        <property type="gene ID" value="VR44_16305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7715"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17917" checksum="1619B9DC03583D78" modified="2015-06-24" version="1">MDAVDLQIIRELQADGRLSNQDLADRVRLSPSPCLRRVRRLEEAGLIRGYTAVVDQVAFGLPITVFVRIRLERHTKEAVALFEQHVAVIEHIQDCYLMAGSSDYLLRVVIEDLEAYEALVRHRIHAIPGIASIESSFAFGSVKQSRTYPRPTPGAAARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHX3</accession>
    <name>A0A0F4JHX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947651.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000336.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33810">
        <property type="protein sequence ID" value="KJY33810"/>
        <property type="gene ID" value="VR44_13160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6850"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="27228" checksum="F070F14A29DE54AA" modified="2015-06-24" version="1" fragment="single">MLSLRLVRGSRPLVQLRRLLVAAACAGSGLLLLYVLADAEARPTGSFPRLLWALVPVAATVQFAVAVARTDPATRPREGLDAVGLGPVRLALAAAVSTAVACTLGSVLALAAFLHLRGELAGLPFDGAGARLLHAGRPLPVAAALTLLALLPLTASAATALALRPRPPHSGLAPQTGVPWGVALTACGLGLLAYARPDGPALPAAGALIAVGLALAGPGLAYACGTLVQAVRPGALRLLAGRTLQEEASRLGRPLGVLCAVGAAALTVALAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI05</accession>
    <name>A0A0F4JI05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000333">
        <property type="protein sequence ID" value="KJY33845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947638.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000333.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33845">
        <property type="protein sequence ID" value="KJY33845"/>
        <property type="gene ID" value="VR44_13095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6680"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18973" checksum="FB44DD02217E9BD3" modified="2015-06-24" version="1">METIEREDGGRKMDDSGSIPQARGGETAAPADPLTYEGVWRFTAPAVEESVPQARRAVRDLLARQEVPATQELVYSLLLIVSELVTNSVRHAALLSPEVGVEVAVGREWVRVAVEDDHPYRPKALEADFGQTGGRGLLLVREVTREAGGVCDVEHTSTGGKVIWAALPLTAPARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIA4</accession>
    <name>A0A0F4JIA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000327">
        <property type="protein sequence ID" value="KJY33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33920">
        <property type="protein sequence ID" value="KJY33920"/>
        <property type="gene ID" value="VR44_12970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28338" checksum="14B0C7BF0B7DE3B4" modified="2015-06-24" version="1" fragment="single">MRVVELAGIGPGPFAAMLLADLGADVVRVDRPGGGGLAIDPAYDVTNRNKRSVLVDLKSPEGPARVLELAERADVLIEGFRPGVAERLGVGPEECLARNPALVYGRMTGWGQEGPLARTAGHDIAYIAVTGALGMIGSPEGPPAVPANLVGDYAGGSLYLVIGVLAALQHARTPGGAGQVVDAAIVDGTAHLTAMIHGMVAAGGWQDRRGVNLLDGGCPFYGTYETSDGRYMAVGALEQQFYDTFVRLLGVADEAPARKDLARWGELREAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIF4</accession>
    <name>A0A0F4JIF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042811709.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33548">
        <property type="protein sequence ID" value="KJY33548"/>
        <property type="gene ID" value="VR44_13705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7017"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6640" checksum="ECF32CD526D3286C" modified="2015-06-24" version="1">MPIVTVQQGPRSIELKRELVARITDAFVDTLQLPAETVQVWIHEVPADSWAAAGKLTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ01</accession>
    <name>A0A0F4JJ01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947515.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34170">
        <property type="protein sequence ID" value="KJY34170"/>
        <property type="gene ID" value="VR44_12445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6548"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7687" checksum="0B7FF5B4B72D7100" modified="2015-06-24" version="1">MSTNSPDPDPRNTTGLEPGGSVPPGETPPAEASTASGAGPHRPPKRGWSKGPLVAIVLLAVLVALFFLAYGIVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ65</accession>
    <name>A0A0F4JJ65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3887 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34392">
        <property type="protein sequence ID" value="KJY34392"/>
        <property type="gene ID" value="VR44_12015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6488"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470549" description="DUF3887 domain-containing protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="16758" checksum="9D53402487D5BF40" modified="2015-06-24" version="1">MTVLPRSGASVRHAAHVAVAVVATAALCVVAEGSAEAAPPATARVGAVAVPGRDDSYGRSALDTLAEVVRGDFDAVSARFDTALRQQASPEVLRKSWEAYQAGFGRYLSHGEPRQAVTAAGTVVSVPLRMAKQPGEFRVTFNTDGRLTGLWFLRPGVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJM3</accession>
    <name>A0A0F4JJM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">VR44_14375</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947870.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3329"/>
    <dbReference type="EnsemblBacteria" id="KJY33171">
        <property type="protein sequence ID" value="KJY33171"/>
        <property type="gene ID" value="VR44_14375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7224"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18537" checksum="6D944A0EAA6D9CDF" modified="2015-06-24" version="1">MRVLGVDPGLTRCGVGVVEGVAGRPLTMVGVGVVRTPADAELGQRLVAIERGIEAWLDEHRPEFVAVERVFSQHNVRTVMGTAQASAVAMLCAARRGIPVALHTPSEVKAAVTGSGRADKAQVGAMVTRLLRLAEPPKPADAADALALAICHIWRAPAQNRLQQAVAQHALKGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJN2</accession>
    <name>A0A0F4JJN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947880.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33181">
        <property type="protein sequence ID" value="KJY33181"/>
        <property type="gene ID" value="VR44_14395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7228"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19688" checksum="3672F5669DFE8C9C" modified="2015-06-24" version="1">MIENLVWIAVAFAVVGVYLSWTAGRLDRLHTRMDAARAALDAQLVRRASVVLEVATSGALDPASSLVLYEAAHAARQAEEEQREVAESELSQALRAVFADADQVEVLKSAPGGVEAAEQLAAAVRRVPMARRFLNDAVRAARALRRHRKVRWFRLAGHAPFPLAFEMDDEPPADLADRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKA5</accession>
    <name>A0A0F4JKA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4015 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34249">
        <property type="protein sequence ID" value="KJY34249"/>
        <property type="gene ID" value="VR44_12355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6456"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025275">
        <property type="entry name" value="DUF4015"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13200">
        <property type="entry name" value="DUF4015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4015" evidence="1">
        <location>
            <begin position="222"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="541" mass="56742" checksum="FD777549AF1F3F0E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLV3</accession>
    <name>A0A0F4JLV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000327">
        <property type="protein sequence ID" value="KJY33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947611.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000327.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2307"/>
    <dbReference type="EnsemblBacteria" id="KJY33916">
        <property type="protein sequence ID" value="KJY33916"/>
        <property type="gene ID" value="VR44_12950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6707"/>
    <dbReference type="eggNOG" id="COG1515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="19581" checksum="6F872D10F8E1C195" modified="2015-06-24" version="1" fragment="single">DVAYDDERDLVAAAAVVLDAATLEVVAEATAVGHVSFPYVPGLLAFRELPTVLAALEALPVTPGLVVCDGYGLAHPRGFGLACHLGVVTGLPSIGVAKNPFTFTYEEPGPPRGEASPLLAADGSVVGRALRTQHGVKPVYVSVGHRVSLDNACAHTLALSPRYRIPETTRHADSLCRRALREAGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMJ3</accession>
    <name>A0A0F4JMJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947043.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000213.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35582">
        <property type="protein sequence ID" value="KJY35582"/>
        <property type="gene ID" value="VR44_09905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5530"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="475" mass="47812" checksum="42366DE77824F9EE" modified="2015-06-24" version="1">MATTNFEGYSHEQLLAMIASLDPETVKARATQLADAAIALNEIGDSLKRHEVKGWEGEAADKFQDWVSRAGNATLTLGKYSDVGSQWMTHAAQTMIEVKANTPKYDKGAADNLEAARKYHNDPDAQQVGQTAHAKLTADHEQAVQQLTKLAQSYDWSATQLSSAEAPTFPPPPGVFEPSKSEGSTYIDRASGGQSPGGYSGSPGYGTSGAGTGGSHQSNGVVTGLPQSGDHSLPSATGPAPTHPPTVLPDRGVDVDLDHVATLPDKTIPPTSGLPVGPGPGMPGGNPPSGPVLPLPLPSIGGPSSLGGGPVPITRPPVGIGGKVGGIPVPSPRDTGIVGGRPISTGGSSAGIPRSTVIGAEGPHTGGGRGMPGMMGGGLGGPHGTPGGRAAGRRLSMEPGGVVGGRQAAAGGQPFTQGGSGLVRGSGTGVVGHGGATSQAPSRRRADQGGDRPDYLAEDEETWQGNRRVVPPVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN38</accession>
    <name>A0A0F4JN38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35782">
        <property type="protein sequence ID" value="KJY35782"/>
        <property type="gene ID" value="VR44_09170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7572" checksum="CDCCBA91A8EE2323" modified="2015-06-24" version="1">MTYTDGFGYTEYAGDARPGFARLLGDCARMAPHWAVPPEPRPVRVAPSQIHGVSVPPASARLIAATAEYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNH3</accession>
    <name>A0A0F4JNH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947409.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34461">
        <property type="protein sequence ID" value="KJY34461"/>
        <property type="gene ID" value="VR44_11870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6379"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14443" checksum="67F64823DDFBDEAF" modified="2015-06-24" version="1">MTVPKTSVLVLDCAEPEALAGFYASLLGARTAPAEGDPDLLLVAGPSGALLGIRRDPDRVPPSWPLPDGPEQPHLRILVTPDALDEAEREAVALGARPLAAETTAADPASRTTHRRYADPAGHAFVLAATGLTANGAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNS9</accession>
    <name>A0A0F4JNS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000193">
        <property type="protein sequence ID" value="KJY35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2372"/>
    <dbReference type="EnsemblBacteria" id="KJY35860">
        <property type="protein sequence ID" value="KJY35860"/>
        <property type="gene ID" value="VR44_09000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4973"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="25033" checksum="C2C10DA5AF769866" modified="2015-06-24" version="1">MEAVFGHLRSAIERGEYAVGDKLPSEAELCRTLEVSRPVLREALRALQAMGLTVSRSGKGTFVVANTVEDPTFGDYAASDLLEVRRHVEIPVAGYAALRRTPEDLDHLGHLLDRMEQETDTTAWVAMDTVFHLAVAEASRNPVFRRVIEEIRDALARQSTFLNELGGRREQSNCEHRAILEALVDGSEHDAVEAMSHHLLRVETTLTDIVRPQRTTALTEGRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP22</accession>
    <name>A0A0F4JP22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="8" type="ORF">VR44_08500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946782.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene936"/>
    <dbReference type="EnsemblBacteria" id="KJY36122">
        <property type="protein sequence ID" value="KJY36122"/>
        <property type="gene ID" value="VR44_08500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4763"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="461" mass="50876" checksum="EF9F471B62EF991A" modified="2015-06-24" version="1">MSTLAHIAAQQPHVLAAEDLSLFGTDVWWLVLVKAVFCFAFLMVTVLFSIVWERKVVAWMQLRIGPNRHGPWGMLQSLADGVKLMLKEDVVVKRADKVVYVLAPVIAAIPAFMAIAVIPFGPSGNEVSIFGQRTTMQLTDLPIAMLYVLAVASVGIYGIVLAGWSSGSTYPLLGGLRSCAQMISYEIAMGAAFASVFLYSGSMSTSQIVEAQADRWYIVLLPVSFIIYVITMVGETNRAPFDMPESEGDLVGGFNTEYSSIKFALFMLAEYVNMVTVSAVSVTLFLGGWRAPAPISTYWEGANHGWWPMLWFVIKVQLLLFFFIWLRGTLPRVRYDQLMKLGWKVLIPVSVVWLMLVATVRALRNERYDFSEIVLYVGGAVVAILLLTSVADHFRDKREKTAAERAGKAAAAEPFDPMAGGFPVPPKPGQHLAPVPRRRPRAERELIVSGGTNTDSDREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP89</accession>
    <name>A0A0F4JP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000172">
        <property type="protein sequence ID" value="KJY36187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36187">
        <property type="protein sequence ID" value="KJY36187"/>
        <property type="gene ID" value="VR44_08395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4578"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6520" checksum="3A7E6133C251F3AF" modified="2015-06-24" version="1" fragment="single">MAGYYPVPRPVTNGLAVAGLVLGLLAVVLGIIPFFFWLGVLLALTGIGISGGAIARARKGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPD9</accession>
    <name>A0A0F4JPD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946735.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36237">
        <property type="protein sequence ID" value="KJY36237"/>
        <property type="gene ID" value="VR44_08260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4551"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="24810" checksum="D0B248B70AB73152" modified="2015-06-24" version="1">MPRPYVLLSVATSVDGYIDDTSTTRLLLSNSEDFDRVDQVRAESDAILIGAGTMRSDNPRLLVNSEERREARVAAGKPAYPLKVTISASGDLDADLKFWHHGGDKLAYTTDAGEEKLQETLAGLADVVSTGPTIDFGALLDDLGARGIERLMVEGGGQIHTAFLSQGLADEIHLAIAPLVVGDPGAPRFLNPASYPGGSTRRMRLAEATTIGDVVLLRYLPKQEGPREARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRI9</accession>
    <name>A0A0F4JRI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000214">
        <property type="protein sequence ID" value="KJY35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947053.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000214.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35546">
        <property type="protein sequence ID" value="KJY35546"/>
        <property type="gene ID" value="VR44_09945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5537"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7225" checksum="C5CF085063ABDCAE" modified="2015-06-24" version="1">MNELIISLSDAEYAECADLADASGATPEELALAAVREHLRRERERVGTVAERLALLHAPLLKRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRJ3</accession>
    <name>A0A0F4JRJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946688.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36444">
        <property type="protein sequence ID" value="KJY36444"/>
        <property type="gene ID" value="VR44_08005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4426"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9572" checksum="CB5A20CD22058664" modified="2015-06-24" version="1">MRDSYARGESITAQRHSRIMQKADAIQFRQRREDEETSVVLGRTSLAASLMAVSFAGAFPGAVISHALGLISVVPGLVTVFLRIKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRR1</accession>
    <name>A0A0F4JRR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36885">
        <property type="protein sequence ID" value="KJY36885"/>
        <property type="gene ID" value="VR44_06960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3607"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471183" evidence="1">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="39547" checksum="DF42E3196E49DAD2" modified="2015-06-24" version="1">MGGRRMVAAVAVGVLALGVVAQPVAFAAGRPDSVQRGLDGLVRAGGVPGALATVTEGDGRSRVYTAGVGDFATGAAVPRDGQVRIGSNTKVFTAVVLLQLVGEGRLGLDDLVEEHLPGVVRGEGFDGRKITVRQLLQHTSGIPDYEAEVGEAIERGRYVEPREVLEIAFRHPATSSDGKTFHYSNTNYVLAGLIVEKVARRPLAEEIDRRVVKRLGLRHTYFPAPRDRGIREAHPHGYHQDVVGGPLRDVTVIDPSAAWAAGQMVSTNSDMNRFFSALLGGRLLRDEQLRAMRTTVPVVKGSDVGYGLGLMRRPLSCGGVYWGHGGDITGFETRGGVGPDGRAVSVAVTADPVDYGVTERLEGLVDRALCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS39</accession>
    <name>A0A0F4JS39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36649">
        <property type="protein sequence ID" value="KJY36649"/>
        <property type="gene ID" value="VR44_07590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3995"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="533" mass="54311" checksum="E68AC6DA56259429" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSJ4</accession>
    <name>A0A0F4JSJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36804">
        <property type="protein sequence ID" value="KJY36804"/>
        <property type="gene ID" value="VR44_07175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3779"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471197" evidence="2">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="14967" checksum="8F15D3A4DC8D62BC" modified="2015-06-24" version="1">MFAVVMGVLAVALALAGPVRGTTDRAPGTRAAAAVAAPPPAVGMPAERTAPRRAASAWPGGRPGPADAERAGRPEAGPGTHVAFAGVVPPRGPSCAPDSGGLGTEPAVPASRAGHEHGSVLVARAVPEGCGRTGPSAYGCPCAGPACGRRGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT51</accession>
    <name>A0A0F4JT51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_05475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000101">
        <property type="protein sequence ID" value="KJY37537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946220.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37537">
        <property type="protein sequence ID" value="KJY37537"/>
        <property type="gene ID" value="VR44_05475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1732"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="29998" checksum="B2350C8426831371" modified="2015-06-24" version="1">MLRVLAVDDEKPLLEELLYLLRSDERVLSAEGASDATEALRRITRAVESGPDGPDAIDVVFLDIQMAGLTGLDIARLLAGFARPPLIVFVTAHEGFAVQAFDLEAVDYVLKPVRPERLAEAVRRARDLLGRPVREQEPEPERAAVPAPRRQAAEASAAERPPEQIAVELGGVTRFVAIADIAYVEAQGDYARLHTDEGSHLVRIPLSTLEERWAARGFVRIHRRHLVALSRIDELRLDAGTTTVRIGPAELQVSRRHARQLRDLLMRQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTP7</accession>
    <name>A0A0F4JTP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_08165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000165">
        <property type="protein sequence ID" value="KJY36351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene275"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="KJY36351">
        <property type="protein sequence ID" value="KJY36351"/>
        <property type="gene ID" value="VR44_08165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="11">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY36351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="27259" checksum="B7DC606169E22A41" modified="2015-06-24" version="1" fragment="single">AWPVNIGFLARGSSSDPAPLVEALAEGGASGFKVHEDMGAHTRALDTALRVAEEHDVQVALHSDGLNECLSVEDTLRVLEGRTIHAFHIEGCGGGHVPNVLKMAGVPNVIGSSTNPTLPFGRDAVAEHYGMIVSVHDLKPDLPGDAAMARDRIRAGTMGAEDVLHDLGAIGITSSDAQGMGRAGETIRRTFAMAAKMKGELGPLEGDGEGDDNARVLRYMAKLTINPAIAHGLAHEIGSIEVGKLADIVLWRPAFFGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUK9</accession>
    <name>A0A0F4JUK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_05660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946254.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37423">
        <property type="protein sequence ID" value="KJY37423"/>
        <property type="gene ID" value="VR44_05660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1947"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="29680" checksum="FB9AD4380501D7FA" modified="2015-06-24" version="1">MELLHFAFMQRALLAAALVGITAPAIGTYLVQRRQAVMGDGIGHVAMTGVALGFLLNTSPVWMATLVAVVGAVGMELIRSRGKTSGDIALAMLFYGGLAGGVMIINLSPGGSTANLSSYLFGSITTVSAEDITAVVILAAFVIAVTLGLRRQLFAISQDEEFARVTGLPVRALNLLMAVTAAVTVTVAMRIVGLLLVSAMMVIPVAAAQRVTRGFAATLSLAMGIGVVVSLSGTAVTYYIDAPSGATIVLLAIAVFVATTALSTPLARRRAKAARAAEEVCTRDDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXI3</accession>
    <name>A0A0F4JXI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945888.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38438">
        <property type="protein sequence ID" value="KJY38438"/>
        <property type="gene ID" value="VR44_03640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8266"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17757" checksum="49C1503A793E7269" modified="2015-06-24" version="1">MDFEIRTAREDEYERLGEITGQAYTGDGLLDLNDDDHYLNVLRDVAGRAADGEVLVAVRDGEVLGGVTFAAPGSRLADIAGPHDAEFRMLAVAAGARGQGVGEALVRACAERARALAGVTALVLSTQPAMRGAQRIYERLGFVRTPELDWSPLPALTLLTYRMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY22</accession>
    <name>A0A0F4JY22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_04685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946074.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37901">
        <property type="protein sequence ID" value="KJY37901"/>
        <property type="gene ID" value="VR44_04685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1018"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1712"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1674"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1877" mass="193052" checksum="DEE9A712C4DC6310" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY70</accession>
    <name>A0A0F4JY70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945562.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39332">
        <property type="protein sequence ID" value="KJY39332"/>
        <property type="gene ID" value="VR44_01905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5785"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="39809" checksum="B8874141AFB5CA5A" modified="2015-06-24" version="1">MDVFITGLGAISCLGDGPEAFWKGLHAGRSGPTPVESLTGQVRAPLAYQVPPATDASAHAEDDATRGRVSRFALHAARQAVVDAGLTGEEVAGMAVVIATAIGVCEEREDAFRAGVPDDAVWTPSFSVASAVGDALGSFGANISVSNACAASGYALSVAMDLVRRGEAETVLVGGAEGSAGVPIAAFDRLGAIDPDGCRPFEADRKGTVFGEGAAMLVVQSARAAAGRRTYGRLSGTAWSCDAYHTTAPDPGRRQLVRAAREALRDAGCGPEAIGCVIPHGTGTQPNDLLESETLRDVLGQRCDSTPLFSLKAFIGHTAGAAAAFSAVCGALVLRHGQVPPNIALARQDPACDVWLPQDGPTPLPRPGVLINSYAFGGSNVSLVLDGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYP3</accession>
    <name>A0A0F4JYP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium transporter KtrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_02690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000044">
        <property type="protein sequence ID" value="KJY38873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38873">
        <property type="protein sequence ID" value="KJY38873"/>
        <property type="gene ID" value="VR44_02690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY38873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="45745" checksum="84DCBFB9B9A21846" modified="2015-06-24" version="1" fragment="single">MSTATPTRAPHQDVPTGHKPEGGRVGGGLFDPKQLLKSFPDAVKKLDPRVMVKSPVMFVVLVGSVVTTVLALMDPTDWFGWAITAWLWLTTVFANLAEAVAEGRGKAQADTLRKAKTDTVARRLAEDGTTEEQVPGTELKIGDLVVCEAGDVIPGDGDVVEGVASVDESAITGESAPVIRESGGDRSAVTGGTKVLSDRIVIKITTKPGETFIDRMINLVEGAARQKTPNEIALNILLASLTIVFLLAVVTLQPFAVYAGAKQSMIVLTALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVSTLLLDKTGTITYGNRQAAEFVPVKGTTAAELADAAQLSSLADETPEGRSIVVLAKEKYGLRERHQGELAHATWIEFTAQTRMSGVDVDGRKIRKGAAGSVIAWVTEQGGRLTAESGSLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ54</accession>
    <name>A0A0F4JZ54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypoxic response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000039">
        <property type="protein sequence ID" value="KJY38983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945691.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38983">
        <property type="protein sequence ID" value="KJY38983"/>
        <property type="gene ID" value="VR44_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14406" checksum="B7EC2AA0DAD1939E" modified="2015-06-24" version="1" fragment="single">MATAREIMHKGASCVQEDETLMDAARRMSELGVGSLPICGPDDRLHGIITDRDIVVKCLAKGKDPHHMTAGMLAQGKPYTVAADADTGQVLEIMQEHRVRRLPVIDDHRLVGMISEADLARHLTEEQVGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0I0</accession>
    <name>A0A0F4K0I0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">VR44_00990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945398.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4747"/>
    <dbReference type="EnsemblBacteria" id="KJY39619">
        <property type="protein sequence ID" value="KJY39619"/>
        <property type="gene ID" value="VR44_00990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2911"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="15740" checksum="A271905226B4FBCB" modified="2015-06-24" version="1">MKIILTHEVSGLGTAGDVVDVKDGYARNYLVPRGFAIRWTKGGEKDVAQIRRARKIHEIATIEQANEVKAQLEGVKVRLATRAGDAGRLFGSVTPADIATAIEASGGPKVDKRRVELGSPIKTLGSYQVSVRLHAEVAANVGIEVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0J5</accession>
    <name>A0A0F4K0J5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">VR44_00180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818558.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1001"/>
    <dbReference type="EnsemblBacteria" id="KJY39915">
        <property type="protein sequence ID" value="KJY39915"/>
        <property type="gene ID" value="VR44_00180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.33"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15356" checksum="AE72837FFE61F2E6" modified="2015-06-24" version="1">MPPKKKKVTGLIKLQIKAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGMVVPVEITVYEDRSFTFVTKTPPAARLILKHAGIEKGSGEPHKTKVAKLTRDQVREIATIKMPDLNANDLDAAEKIIAGTARSMGVTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3A9</accession>
    <name>A0A0F4K3A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_00920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000013">
        <property type="protein sequence ID" value="KJY39661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945385.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39661">
        <property type="protein sequence ID" value="KJY39661"/>
        <property type="gene ID" value="VR44_00920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2895"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="655" mass="68346" checksum="E51B0C82CABAE424" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBZ9</accession>
    <name>A0A0F4IBZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_39190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001562">
        <property type="protein sequence ID" value="KJY19204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952463.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001562.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19204">
        <property type="protein sequence ID" value="KJY19204"/>
        <property type="gene ID" value="VR44_39190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5602"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY19204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="700" mass="71942" checksum="03A281CC1ACDC59D" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IF53</accession>
    <name>A0A0F4IF53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001495">
        <property type="protein sequence ID" value="KJY20637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952358.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20637">
        <property type="protein sequence ID" value="KJY20637"/>
        <property type="gene ID" value="VR44_38630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5400"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="20670" checksum="68B844EE215253DF" modified="2015-06-24" version="1">MSREAFEAIAEAAAQHDVKLEFINGELGVKPVPDGDHGEIIMWLLEHCMRQRPDLRLYPKQGLRVDTYGNGNARPDGALAPKGYFAGQGEWAGTEGVVMVVEVTSYDTRTDQHDRQDKPRAYAEREIPVYLLIDRDNGSLVLHTEPVNGRYHTQRFFFGDTVRIPAPVDITLDDTDILKNHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFW9</accession>
    <name>A0A0F4IFW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_39070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="JZWV01001547">
        <property type="protein sequence ID" value="KJY19546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952442.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001547.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19546">
        <property type="protein sequence ID" value="KJY19546"/>
        <property type="gene ID" value="VR44_39070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5575"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="17390" checksum="9EFEB26C250C27C3" modified="2015-06-24" version="1">MGVSGTGKSTVGRLLAEALGVPYAEGDAFHPAANVARMSAGIPLEDADRWPWLDAVGAWIRGRGTGGGVVAASCLRRAYRDRLRAAAPAGVVFVHLTGRRPLIAARMAARTGHFMPASMLDSQFAVLEPLHPDEPGFAVDVAGTPEEITARALSALRPPGGRDTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IG69</accession>
    <name>A0A0F4IG69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001471">
        <property type="protein sequence ID" value="KJY20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20997">
        <property type="protein sequence ID" value="KJY20997"/>
        <property type="gene ID" value="VR44_38410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5332"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8328" checksum="34E62152D1800735" modified="2015-06-24" version="1" fragment="single">PKAYITLAAGWEPGKETARLLFAHSRAVLSPYKRIRRIEFAELPKTVSGKIRRVELRDLTAAGSAQEYDEADLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHN6</accession>
    <name>A0A0F4IHN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001452">
        <property type="protein sequence ID" value="KJY21540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21540">
        <property type="protein sequence ID" value="KJY21540"/>
        <property type="gene ID" value="VR44_38250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY21540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="28732" checksum="C171055D4984FF3A" modified="2015-06-24" version="1" fragment="single">MTTPPPSATPDSSATPAPDRPEPSPAAVPSGAAGRSGPRPAPWVRTRLRAARLGSVLAAVLAFVAVLLAAALPRAQDRGADQALRSFLQRGGPGYTSLLATAPPPRQGQGTDRLDATRDTLLAHTGGSFHVDPDAVVYGNWTVKGRSLTNPGLSAPSGLPPVMRLLYVHDARAHVRLVEGHWPQDAPAAATAPGTAGNTAEDGPPLRIALSQRAARTIGARLGSVLTTSPVPGAGPRVEVVGLYTVLDETEDFWADLGCLAFACEYHQGDNAYWAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILZ0</accession>
    <name>A0A0F4ILZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">VR44_37715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001402">
        <property type="protein sequence ID" value="KJY23022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952186.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001402.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5420"/>
    <dbReference type="EnsemblBacteria" id="KJY23022">
        <property type="protein sequence ID" value="KJY23022"/>
        <property type="gene ID" value="VR44_37715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5049"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY23022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="392" mass="41161" checksum="5C3D114601D2AF19" modified="2015-06-24" version="1">MDLFEYQARDLFAKHGVPVLAGEVIDTPEAAREATEKLGGKSVVKAQVKVGGRGKAGGVKLASTPDEAVARATDILGMDIKGHTVHKVMIAETAPEIVEEYYVSYLLDRTNRTFLAMASVAGGMDIEQVAEETPEKLAKVPVNANEGVTIEKAREIVELAQFPAEVAEKVAEVLVTLWKTFIAEDALLVEVNPLAKVASGEVIALDGKVSLDENAEFRQPGHEEFVDHAAANPLEAAAKEKGLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGENHGGVKPANFLDIGGGASAAVMANGLEIILGDPDVKSVFVNVFGGITACDEVANGIVQALQLLEDRGEAVTKPLVVRLDGNNAELGRKILSDANHPLVQRVDTMDGAADKAAELAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM67</accession>
    <name>A0A0F4IM67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_38185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001446">
        <property type="protein sequence ID" value="KJY21716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952275.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001446.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21716">
        <property type="protein sequence ID" value="KJY21716"/>
        <property type="gene ID" value="VR44_38185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5244"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY21716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="30515" checksum="BF66516683514F2B" modified="2015-06-24" version="1" fragment="single">MGTASNLHLYAGRASGLIGRQIAGYLVERMIGRGGMAVVYQARDLRLDRTVALKLIAPERARDETFRRRFTHESRVAASIDHPHIVPVFEAGETDGVLYIAMRYVAGLDLRVLLDREGPLPVTTALRIAGQVASALDAAHRHDLVHRDVKPGNVLVAAGTDSDHPEHIYLTDFGLTKKALSPAGFTTAGEFVGTVDYMAPEQISGRPVDGRCDLYSLACVVYETLAGGPPFGRDTEPTALLWAHQYDQPPALTATRPDIPPAVDEVLARGLAKVPEDRYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPT8</accession>
    <name>A0A0F4IPT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001386">
        <property type="protein sequence ID" value="KJY23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952157.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001386.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23699">
        <property type="protein sequence ID" value="KJY23699"/>
        <property type="gene ID" value="VR44_37575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4938"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="14041" checksum="991952C7CC949FE3" modified="2015-06-24" version="1">MSTNATVSDFYCHQALTGQVETRPVMETERVLAFHHTNPSYPVHIVVIPKEHVPSLTDLGSAGPDLLAEVVGVVRDVAALVEAERGACSVVTNLGLYQESKHMHWHVLWRGESETEIRSTYGHHDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPY2</accession>
    <name>A0A0F4IPY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001296">
        <property type="protein sequence ID" value="KJY24085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24085">
        <property type="protein sequence ID" value="KJY24085"/>
        <property type="gene ID" value="VR44_36355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4523"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="54" mass="5700" checksum="9C6270C70ED2AEDD" modified="2015-06-24" version="1" fragment="single">MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ95</accession>
    <name>A0A0F4IQ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001271">
        <property type="protein sequence ID" value="KJY24195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951881.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001271.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24195">
        <property type="protein sequence ID" value="KJY24195"/>
        <property type="gene ID" value="VR44_36075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4454"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="23113" checksum="39C89BFC560AADF6" modified="2015-06-24" version="1" fragment="single">PRRPPDRPVEEGGREAAFTAVDLRDPAAVGEFLDGVAGRYGRLDCLVNNAGGTPYRLLGEGGPERHARVVALNLVAPLTASLAAYPWLRASRGSVVMIGSVSGTRPSPGTAAYGAAKAGLENLARSMAVEWAPEVRVNSLVLGMVRTELAHLHYGDGAGVAAVAATVPLGRLAEPADVGEAAVFLASDRAAYVSGASLLVHGGGERPAFLAAATANQGEAGGVTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQE6</accession>
    <name>A0A0F4IQE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001385">
        <property type="protein sequence ID" value="KJY23703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23703">
        <property type="protein sequence ID" value="KJY23703"/>
        <property type="gene ID" value="VR44_37555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4934"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11106" checksum="DC078EEE2793C65D" modified="2015-06-24" version="1">MTTVEDEGPLTVRGAGPARSPGQGRDAVLALGLLGTAVAGVAAFLKAVSADGIRLPMAPVVALALLLLGVLLARWSLHRPGGGAAPRRPTGARRHPHPPASPTSGARPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQU3</accession>
    <name>A0A0F4IQU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001308">
        <property type="protein sequence ID" value="KJY24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24029">
        <property type="protein sequence ID" value="KJY24029"/>
        <property type="gene ID" value="VR44_36535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4612"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="13882" checksum="C0A622180F57CA97" modified="2015-06-24" version="1">MYAVGGFDSTQTNVVQSYNPAANTWTPVASLPTPRSNMGTTATTCPPGQSGTCIYIVGGLYVTHLLASVQSYNPASNIWTDLPPMPTPRWQLGAVAMPCPTGVGGNCVYASGGADGSDVLATLEALDPPEHTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQW7</accession>
    <name>A0A0F4IQW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001234">
        <property type="protein sequence ID" value="KJY24397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030227569.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001234.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene682"/>
    <dbReference type="EnsemblBacteria" id="KJY24397">
        <property type="protein sequence ID" value="KJY24397"/>
        <property type="gene ID" value="VR44_35505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4215"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10802" checksum="905D19D689F4E9FF" modified="2015-06-24" version="1">MYVGTLSFDLLLGDVHSLKEKRSVVRPIVAELQRKFSVSAAEVGDQDLHRRARIGVALVSGDAGFVSDVLDRCERLVAARPEVELLSVRRRFHGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRB5</accession>
    <name>A0A0F4IRB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001211">
        <property type="protein sequence ID" value="KJY24532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24532">
        <property type="protein sequence ID" value="KJY24532"/>
        <property type="gene ID" value="VR44_35085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="228"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="331" mass="34268" checksum="CF5BCA8A8700144C" modified="2015-06-24" version="1" fragment="single">LLQERLAPHADRLVIAAHNGPGSHVVSGDGEAVRALRAELEDEGVRCGGVRLGAAAHSAHVDAVRDRILSALTGLAPRAAHTPLYSSATGGIVDGRTLDGAFWSEALRRPVRFEQTTHALLADGHEALVEISPHPMLTAAMQETAAAAGRHAVTIATLRRGQGGLRRLRTALAEACVQGVDVDWAPAFPAAGTAGRVQLPTYPFQRSSADGPAATTRLALLPEAEREHTAAALVRSLTAALLGLPGPDAVTPGQAFRDLGMDSVTAVELRGRLNGATGLRLPPTVVFDHPTPAALTARILAEALGTHEDPAGADTTAAAWDEPVAIVAMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS95</accession>
    <name>A0A0F4IS95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosylmethionine synthetase</fullName>
            <ecNumber evidence="3">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001243">
        <property type="protein sequence ID" value="KJY24353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24353">
        <property type="protein sequence ID" value="KJY24353"/>
        <property type="gene ID" value="VR44_35645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="8984" checksum="203FCB00F4667074" modified="2015-06-24" version="1" fragment="single">MSKRLFTSESVTEGHPDKIADRISDTILDALLREDPASRVAVETLITTGQVHIAGEVTTTAYAPIAELVRGAILDIGYDSSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISE6</accession>
    <name>A0A0F4ISE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001201">
        <property type="protein sequence ID" value="KJY24574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24574">
        <property type="protein sequence ID" value="KJY24574"/>
        <property type="gene ID" value="VR44_34955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046288">
        <property type="entry name" value="DUF6325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19850">
        <property type="entry name" value="DUF6325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8677" checksum="E5F8D96E1776B387" modified="2015-06-24" version="1" fragment="single">MGPIDYLVVEFPGNRMTGEGFPLLVDLVDRGLIRILDLVFIRKDQDGSVAALEIADLDADGELDLAVFEGASSGLLGQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL0</accession>
    <name>A0A0F4ISL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein, TerZ-and CABP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001226">
        <property type="protein sequence ID" value="KJY24453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951740.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001226.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24453">
        <property type="protein sequence ID" value="KJY24453"/>
        <property type="gene ID" value="VR44_35325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4177"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="691" mass="73304" checksum="062638DE802F6411" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITD7</accession>
    <name>A0A0F4ITD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001175">
        <property type="protein sequence ID" value="KJY24738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4275"/>
    <dbReference type="EnsemblBacteria" id="KJY24738">
        <property type="protein sequence ID" value="KJY24738"/>
        <property type="gene ID" value="VR44_34460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3873"/>
    <dbReference type="eggNOG" id="ENOG5031FDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="53" mass="6092" checksum="2DB76B07E7019F2C" modified="2015-06-24" version="1" fragment="single">LDHLKDVVDETGADEVIVLTAPHFVEEFFHRDWASRARHKVGVPVLKLFAHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITL7</accession>
    <name>A0A0F4ITL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001309">
        <property type="protein sequence ID" value="KJY24021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951970.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001309.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24021">
        <property type="protein sequence ID" value="KJY24021"/>
        <property type="gene ID" value="VR44_36560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4617"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469787" evidence="1">
        <location>
            <begin position="33"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="18116" checksum="F496EEEEEABB4E02" modified="2015-06-24" version="1">MNSGTTTRTFRTACATVLTAALLTAAAPAASAAGGPSVAQPANAAKVVTADGGGAYLDLATAGYTYEEALEAFKDSDVVTVVRGDLRREDGEAPSRVARGVSLGWYVYVKLSKSQAKAVNAGSAATAAGLIGVVTGGIGAAVAAGVYAYMVSLGNEGIDRCKSGVEMKFTYTGKAAGVKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITN3</accession>
    <name>A0A0F4ITN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001084">
        <property type="protein sequence ID" value="KJY25372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951248.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25372">
        <property type="protein sequence ID" value="KJY25372"/>
        <property type="gene ID" value="VR44_32650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3339"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="9170" checksum="1863CCA9B034D2CA" modified="2015-06-24" version="1">MSVTTEATGLGGRQRGADARATGLTMPQAVVISVVMPVVFVLAVVLSLRGMPMGEVFRLLGGAGAIGAALVVAVTPGGRGAVAAAARAALQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUA9</accession>
    <name>A0A0F4IUA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PASTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_32085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001050">
        <property type="protein sequence ID" value="KJY25600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951143.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25600">
        <property type="protein sequence ID" value="KJY25600"/>
        <property type="gene ID" value="VR44_32085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3135"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470264" description="PASTA domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="21445" checksum="10517607EE2E1657" modified="2015-06-24" version="1">MHRRHAITLFTAATALALTACNPQASGTNGKPAAPDAPSPKTSAPSAPAAGAKTGTLPNLVGKGLQTAQDEAQAAGFYALKSHDALGRARLQALDRNWKVCSQTPAGGGTVDTGTTIDFGAVKLDETCPAADAPAPKPAGDTMPDFVGQGMKAVRAALPSNASISVKDAVQSRMVLQESNWKVCTQNPAAGAALNGRPVSFTVAKIEETCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUQ0</accession>
    <name>A0A0F4IUQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001030">
        <property type="protein sequence ID" value="KJY25745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25745">
        <property type="protein sequence ID" value="KJY25745"/>
        <property type="gene ID" value="VR44_31745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7148" checksum="3B0D5F5A850AEC8C" modified="2015-06-24" version="1" fragment="single">MAAETPPTAPVALAALLADRELDLRRLAGPAEAEVHGVHASEMADPSPYLLGGELLLTAGAGLTGAGAASDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVA1</accession>
    <name>A0A0F4IVA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001010">
        <property type="protein sequence ID" value="KJY25927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950987.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25927">
        <property type="protein sequence ID" value="KJY25927"/>
        <property type="gene ID" value="VR44_31245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2736"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="33226" checksum="B1559004AC935522" modified="2015-06-24" version="1">MAYGMQLPVQSQSTIYAEPWEASAGAADLAEVARAADRAGFGYLATCDHVAIPRRLAGPMGTVWYDPVATLAFLAGITERVRLLSHVAIVGLRHPLATAKQYATLDHLSGGRLVLGVGAGHVREEFEALGADFERRGPVLDETLDALRAALGPEEFPEFEGERFSFRDLGQLPRPAQQRIPVWVGGSSPAAVRRAAVRGDGWLPQGDPRDRIPAQVARIRELREAAGVEGPFEVGAITEPLYVGEPGWDTGRRTLTGKAEVLAESLREYRALGVDQIQVRFRNRDRAELVDQITAFGSEVAPLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVB6</accession>
    <name>A0A0F4IVB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001191">
        <property type="protein sequence ID" value="KJY24631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951630.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24631">
        <property type="protein sequence ID" value="KJY24631"/>
        <property type="gene ID" value="VR44_34750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4018"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="11275" checksum="C333BD3741478C1F" modified="2015-06-24" version="1">MAASGHGWWEKGNCSSDRAKVFNCLYEWYTDNTWRQQACSETKTLKPGGGSVQRTAARRDCRDTQRTSWRNHVDVDVIDEIDTGEKPMNQAEVDCRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW97</accession>
    <name>A0A0F4IW97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001146">
        <property type="protein sequence ID" value="KJY24931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24931">
        <property type="protein sequence ID" value="KJY24931"/>
        <property type="gene ID" value="VR44_33925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7273" checksum="07D6F8B9987A6FB1" modified="2015-06-24" version="1" fragment="single">ATLGQVTLAAAVRLSVAAAVHVDAEDAEQDVTAAAGALAAADAGDDDAQFTVDGAEDHELLWFGVQEIPGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWE2</accession>
    <name>A0A0F4IWE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_30220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000948">
        <property type="protein sequence ID" value="KJY26370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950801.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000948.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26370">
        <property type="protein sequence ID" value="KJY26370"/>
        <property type="gene ID" value="VR44_30220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2451"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="510" mass="53974" checksum="5FF622439564EF0A" modified="2015-06-24" version="1">MSRTTPAARPDHQAPPLKDEEERLRELGYQPVLARRMGGFGNFAISFSVISVLSGCMTLYGFGLGTGGPSVMLWGWAGVGLFVLCVGLALAEVTSAYPTSGALYYMADRLGGRRWGWYTGWLNLLGLLGAIAGIDYGAAMFTGAFLNLQFGFVPTPGSTFLIFLAFLLLHAALNLFGVRLVSVLNSVSVWWHLGGVALIVGALAFVPDHHQSVSFVFTKFVNDTGWANPFYVAAVGLLLAQYTFSGYDASAHLSEETSNASVSAAKGIVRSIWASWLAGFALLAGLTFAIQDYAAVAGSATGVPPAQIFLDALGAGGAKALLLVVIVAQLFCGNAEVAAASRMVFAFSRDNALPGSSVWRKVSGRTQTPVPAVWLSVAVAGVLALPSLWSATAYGAVTAINVIGITPAYAIPIYLRLRAGDRFVPGPWSLGRWSRPVGWVAVVWVAVVTVLFCLPQKSPVTIDSMNYAVIALAVVLVLASIWWYAARRSYGTPSAYGTAREQADIAEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWP1</accession>
    <name>A0A0F4IWP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000938">
        <property type="protein sequence ID" value="KJY26455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950769.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000938.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26455">
        <property type="protein sequence ID" value="KJY26455"/>
        <property type="gene ID" value="VR44_30040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20114" checksum="CBB6A162B8575AD5" modified="2015-06-24" version="1" fragment="single">TPAPAAAPAAVTASAPGGNAAILGIDYATWQRDVAAVIDAARPAVEQRIAASPAGEKPAIVLDIDNSSLETDFHWFWTFPTPAIEKVRALTQYANQRGVAIFFVTARPGIVYSLTERNLKAVGYPVTGLYVRDLPALFSEVSAYKTAKRAEIEARGYTIIANIGNNESDLVGGHAERTVKLPDYGGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWP9</accession>
    <name>A0A0F4IWP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001013">
        <property type="protein sequence ID" value="KJY25898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25898">
        <property type="protein sequence ID" value="KJY25898"/>
        <property type="gene ID" value="VR44_31300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2748"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34311" checksum="84141D809D78BCDB" modified="2015-06-24" version="1" fragment="single">VLPPPAAPAPPVPAGADLHVPGVGPFLTPAPDFYRVDTALVVPRVDAGTWRLTVHGDGVSRPLTLTLPELLARPLTEHDITLCCVSNEVGGPYVGNARWLGVRLADLLREAGVRPPSAGGPADQLVARSVDGMTIGTPVETVMDGRDALLAVGMNGAPLPFAHGFPVRMVVPGLYGYVSACKWLTELRLTSFAAYDAYWVRRSWAQQAPVKTQSRIDTPRAFAELAAGRVAVAGVAWAQHRGIARVEVRADGGPWHEARLGDSDGDDTWRQWVWPWEAAPGEHTLEVRATDGRGAVQPEERRGTLPDGATGWHSVTVSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWQ3</accession>
    <name>A0A0F4IWQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000936">
        <property type="protein sequence ID" value="KJY26470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950762.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000936.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2182"/>
    <dbReference type="EnsemblBacteria" id="KJY26470">
        <property type="protein sequence ID" value="KJY26470"/>
        <property type="gene ID" value="VR44_30000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2383"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="33640" checksum="4C88A653463D9590" modified="2015-06-24" version="1">MASNVNPTVRRRRLGMELRKLREDKGMTAEQVAERLLVSQSKISRLENGRRSISQRDVRDLCEVYEVEDPRLVDSLMQMAKDSRQQGWWHAFGDIPYSVYIGLETDAASLRTYEPQMAPGLLQTPEYAQALIRGALPETAPADVEKRVQVRMHRQKRLSETDNNNAEVGPLRLWAVIDEAVLRRHVGDPELMIRQLQFLIEQSHQPYITVQVMPFTMGAHPGVNGQYAILEFPDASDSTVVYIEGVTSDLYLEKANDVQKYSVMYEHLRAQALNVEQTRQFISEVIDHYAALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWS4</accession>
    <name>A0A0F4IWS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_33320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951372.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25131">
        <property type="protein sequence ID" value="KJY25131"/>
        <property type="gene ID" value="VR44_33320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3540"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8163" checksum="79A7FE12F3B4F1C2" modified="2015-06-24" version="1">MGDRWQVEVDRGVCIGSGMCVNHAPDAFTLDSARQSHPRTPETDANEPTLTAAEGCPVEAILITLAATGEPVFPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYS0</accession>
    <name>A0A0F4IYS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950463.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000866.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27147">
        <property type="protein sequence ID" value="KJY27147"/>
        <property type="gene ID" value="VR44_28380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2001"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16588" checksum="976EEE57E101927E" modified="2015-06-24" version="1">MNASTPHYVKAGPLETRFNALFGKLARLGISLAGTAELSVRGRTSGKMQHIPVNPHTFEGAQYLVSARGHSQWVRNMRVAGGGELRVGRKVRPFTVTELTDPAQKAAVLRAYLEKWGWEVNRFFQGVTAKSTDAELEAAAGDHPVFRVTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZE6</accession>
    <name>A0A0F4IZE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000842">
        <property type="protein sequence ID" value="KJY27387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27387">
        <property type="protein sequence ID" value="KJY27387"/>
        <property type="gene ID" value="VR44_27735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1785"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="24987" checksum="8472EC316ED84A0B" modified="2015-06-24" version="1">MTATAPGHGSAVPHTAARPAVAGHPLVRAVGSPLSIEECRAKWKIACYTPLQYREAYDLNPLYRAGITGKGRTIVIVDSFGSPTVQHDLDVYSRQFGIPSTQVQVVKSARRGTPDISMAAAVDGGAWIYSSYDPSATGWDVSGGTSESSPLFSGIVALADQAAGRRLGDIHEALYRLYGRSAYDRSTGIVDVNDGTDNSYQGVTGYAAVNGYDMATGVGTLDAARFVPALAREGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J046</accession>
    <name>A0A0F4J046_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_27170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000811">
        <property type="protein sequence ID" value="KJY27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950247.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000811.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27640">
        <property type="protein sequence ID" value="KJY27640"/>
        <property type="gene ID" value="VR44_27170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1623"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="30497" checksum="A8831A9C8475C62D" modified="2015-06-24" version="1">MAEAPLWRTRGPGRRSTRALRVRGSAAVALLLALAVLLVPPLVQLDQQAVDLSAKLLPPSWAHPFGTDDVGRDLLLRCVYGLRVSLLVGLVAALVATVVGTAVGAAAGALGGWTDRLLMRAVDTLSSVPHLLLGVFVVALFRPGVWPVVASVAVTHWLSTARIVRAEVLSLRGRPYVDAAVSGGASRWRVAVRHLLPGVLPQAGLAAVLMVPHAMWHESALSFLGLGLPAHQASLGTLVQGGRGSLLAGDWWPTLFPGLLLILPTLAIAGLAGAWRDRLNPRRRSELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0C5</accession>
    <name>A0A0F4J0C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000862">
        <property type="protein sequence ID" value="KJY27178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950443.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000862.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27178">
        <property type="protein sequence ID" value="KJY27178"/>
        <property type="gene ID" value="VR44_28275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1899"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="27722" checksum="C342AC04BBFA1B7A" modified="2015-06-24" version="1">MTTIETQAITVELPAAFDPRWSRLPGIHVDGRRITIDPAEYFFRFESNTWLIADWELVKAQLMDVDETTESAVEQLALDFIRNHAASTSDAARVLTTAYEVYAYLFRDEHLAGLGLPQITADHLRMLREAATLMALNKVELDGHISNVGPCWFFPAATSVVFDLDDEMGGMLDEVYHGGWFNEHRRIESIKAHAALGGRLVHGCQSVPDQTGGVVAPYGASMANFRDDLAAFKAGWIEQVYAHRLTAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0N2</accession>
    <name>A0A0F4J0N2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase_S11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_30015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000937">
        <property type="protein sequence ID" value="KJY26461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26461">
        <property type="protein sequence ID" value="KJY26461"/>
        <property type="gene ID" value="VR44_30015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2386"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="123"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY26461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="453" mass="47629" checksum="1028867D09DDAFC2" modified="2015-06-24" version="1" fragment="single">PRPDPAAAPTVRRLDPSERTTQQPLPPRPPLDMLADLTNNPPPPPSPMRTVVRRVKIYAPIVVLLAVILAVVQLVRPLPAPKLVLTAKSQYTFPGGAPELPWPTEGQASMAAAGLGTIGSSGEQKPVPIASVTKSMTAYIIMRDHPFKKGEKGALIDVDKTAETEGQKDKSDNESTLNTVKEGDKISEYDAIAALMIPSANNIARLLARWDSGSQEAFVKKMNDTAKQLGMTNTTYTDPSGLDATTVSTAEDQVKLGLKIVELDALVDITRKPSWTDQTGKNWPNWNRLVPYNESLGIKTGTTTKAGGNLLFAAYKKVGDTNQLIVGAVLGQHKPPIIDTVIAASKNLLVATQKSLEGAPVVKKGDVVGYVDDGVGGRTKVVATADVQAVGWSSLTVDIKLGDGGTKIPGTAKAGTAVGVLTVGDGASQVKVPVALQSELVAPGIGSKLTRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0V3</accession>
    <name>A0A0F4J0V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OpcA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000828">
        <property type="protein sequence ID" value="KJY27499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000828.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27499">
        <property type="protein sequence ID" value="KJY27499"/>
        <property type="gene ID" value="VR44_27360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="33897" checksum="6B52144674B91718" modified="2015-06-24" version="1" fragment="single">MKIDLTETTSSKINAALVQARRDIGTPAIGMVLTLVIVTDEENAYDALKSANDASHEHPSRIVVVVKRVSRSPRSRREARLDAEIRVGADSGTGETVVLRLHGELVDHAQSVVLPLLLPDAPVVVWWPEGAPADLAGDPLGALGQRRITDTYASEHPIETLAARAEAYAPGDTDLSWTRITPWRSMLAAALDQMPQSPVVSATVEGEDENPSCELLAMWLADRLGVPVNRTLSGGPGLTAVRMETKDGSIVLDRADGSLATLSMPGQPDRAVALKRRDTAELLAEELRRLDPDNTYAASLKFGVSRLSTTAPAAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J121</accession>
    <name>A0A0F4J121_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000777">
        <property type="protein sequence ID" value="KJY27975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27975">
        <property type="protein sequence ID" value="KJY27975"/>
        <property type="gene ID" value="VR44_26310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1403"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="8819" checksum="5A1492F4690489D6" modified="2015-06-24" version="1" fragment="single">DPQQRLLLEGAWEAFEDASIDPASVRRTDVGVFAGVIHHDYVTRLARVPEGFGGYLSTGSAGSVASGRIAYTLGLEGPAVTVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J209</accession>
    <name>A0A0F4J209_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28337">
        <property type="protein sequence ID" value="KJY28337"/>
        <property type="gene ID" value="VR44_25570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1213"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="194"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="437" mass="46537" checksum="1C3C6C3424A68D48" modified="2015-06-24" version="1">MDAAALDEVVAFTSELIRIDTSNRGGGDCRERPAAEYAAERLAGAGLEPVLLERTPGRTNVVARLDGTDPSAPALLVHGHLDVVPAEAADWSVDPFSGEVRDGVVWGRGAVDMKNMDAMVLALVRAWARTGTRPRRDIVIAFTADEEDSAVDGSGYLADHHPHLFEGCTEGLSESGAFTLHTGPGRALYPIAAGERGTAWLKLTAHGRAGHGSKPNQDNAVTRLAAAVARIGAHEWPVRLTDTVAACITELAALQGLSVDPRAPGFDLDAVLGKLGPAAALVGATLRNSANPTMFNAGYKLNVIPGHATAYVDGRTLPGGEAEFTAVLDELTGPEVEWEYHHREVALEAPVDGRTYAVLREAVEHFDPDGHAVPFCMAGGTDAKQFSRLGITGYGYSPLKLPPDFDYWALFHGVDERVPVEALHFGVRVLDRALRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J237</accession>
    <name>A0A0F4J237_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950113.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000784.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27919">
        <property type="protein sequence ID" value="KJY27919"/>
        <property type="gene ID" value="VR44_26455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1475"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21098" checksum="3B69EB05968EEFA5" modified="2015-06-24" version="1">MSDLLLVRHGETAWSANGRHTGLTDVPLTARGADEALSLAPYFRDRHPALVLTSPLSRAVATAELAGLTDGVPDPDLHEWDYGGYEGITTAEIQRTHPDWSLWTDGVPPGDARHPGESAAQVGARADRVLARAAEVLRAGKGDVVLVAHGHFLRVLTARYLGLPPEAGRLFLLRTGTVSELSTEHGLPVIAGWNTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2U6</accession>
    <name>A0A0F4J2U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000711">
        <property type="protein sequence ID" value="KJY28657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28657">
        <property type="protein sequence ID" value="KJY28657"/>
        <property type="gene ID" value="VR44_24880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.976"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="22253" checksum="7350DC4D4BE32D05" modified="2015-06-24" version="1" fragment="single">MAVDIGGTKIAGALVHPDGTMTAATRRPTPRGTDPEAVMAAVTEVVAELSADPLWERAVRCGIGSAGPVDTSRGTVSPVNIGAWRGFPVQERVAAELAARGARIPVVLAGDGVAMTAAEHWLGAARGHANALCMVVSTGVGGGLILNNQLHTGPTGNAGHIGHISVAFDGEPCACGGRGCVESLASGTAIARWALAQGWTGPDPTAAGVAASAAAGDPVALAAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J364</accession>
    <name>A0A0F4J364_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000742">
        <property type="protein sequence ID" value="KJY28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1587"/>
    <dbReference type="EnsemblBacteria" id="KJY28309">
        <property type="protein sequence ID" value="KJY28309"/>
        <property type="gene ID" value="VR44_25635"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="246" mass="26630" checksum="C7B65C9DDEAB7ECF" modified="2015-06-24" version="1" fragment="single">MTADAGSSRGFAHDVYDAVIVGGGHNGLVAAAYLARAGRSVLVLERLGHTGGAAVSTRPFAGVDARLSRYSYLVSLLPGKIVRDLGLRFRVRRRTVSSYTPFERDGRPGGLLVGGGEDRTRESFARLTGSDREYEAWRAFYATTGRLAGRVFPTLTEPLPTRAELRARIDDEQAWRMLFEEPLGRAVEERFADDLVRGVVLTDALIGTFADAHDASLAQNRCFLYHVIGGGTGDWDVPVGGMGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J391</accession>
    <name>A0A0F4J391_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000700">
        <property type="protein sequence ID" value="KJY28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28822">
        <property type="protein sequence ID" value="KJY28822"/>
        <property type="gene ID" value="VR44_24490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6498" checksum="47CF914D40D9133B" modified="2015-06-24" version="1" fragment="single">MPVLSETGMEYTRLVVLELAPGEVYAHDCGGAEWIVLPLNGGCELRCTEPFPAPPLPDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4M7</accession>
    <name>A0A0F4J4M7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">VR44_24865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949812.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7580"/>
    <dbReference type="EnsemblBacteria" id="KJY28673">
        <property type="protein sequence ID" value="KJY28673"/>
        <property type="gene ID" value="VR44_24865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.972"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="157"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="390"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY28673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="506" mass="55230" checksum="BCC306EDFDAF943D" modified="2015-06-24" version="1">MTSSSDRSTAVVDPKGTYEVRTYGCQMNVHDSERLSGLLEDAGYVRAPEGSDGDADVVVFNTCAVRENADNKLYGNLGRLAPMKTKRPGMQIAVGGCLAQKDRDTIVKKAPWVDVVFGTHNIGKLPVLLERARIQEEAQIEIAESLEAFPSTLPTRRESAYAAWVSISVGCNNTCTFCIVPALRGKEEDRRPGDILAEVEALVAEGVSEITLLGQNVNAYGSDLGDREAFSKLLRACGQIEGLERVRFTSPHPKDFTDDVIAAMAETPNVMPQLHMPLQSGSDPILRAMRRSYRQERFLGIIEKVRAAIPHAAISTDIIVGFPGETEEDFQQTMHVVREARFASAFTFQYSKRPGTPAADMEGQVPKEVVQDRYMRLVALQEEISWEENKKQVGRTLEVMVAEGEGRKDGATARLSGRAPDNRLVHFTKPEQDVRPGDVVTVEITYAAPHHLLAEGPTTAVRRTRAGDAWEKRNAAPAQPQGVMLGIPTLGVPAPLPAATSGCAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4P5</accession>
    <name>A0A0F4J4P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000663">
        <property type="protein sequence ID" value="KJY29215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949563.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000663.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M43.008"/>
    <dbReference type="EnsemblBacteria" id="KJY29215">
        <property type="protein sequence ID" value="KJY29215"/>
        <property type="gene ID" value="VR44_23495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.641"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470373" evidence="2">
        <location>
            <begin position="24"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M43" evidence="3">
        <location>
            <begin position="198"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="33545" checksum="E5DD84D8B1F8BA75" modified="2015-06-24" version="1">MGTAVLASTLAFAPLTAPTTVAAAAPKTGAEACAEQGSAPANARVAKPKSDHAAEPNELSESQTKAMDADLNKKLSQMKLSPQQLFGAREAAPSLAAAVTTIPVYVHVITDGTQGKLTATDITNQINVLNAAYSGQGNGNVDSGFQFSLAGTDYTDNAAWYNVSDGTQAEKDMKTALRKGGKNALNLYTANLGGGLLGWATFPSSYASAPQMDGVVILNSSLPGGSSTNYNEGDTATHEVGHWMGLYHTFQGGCSGSGDSVADTPAEKSAAFECPTGRDSCTTKAGVDPIHNFMDYTYDSCMYQFTAGQVSRMKSMWTAYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4W3</accession>
    <name>A0A0F4J4W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">VR44_24340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000697">
        <property type="protein sequence ID" value="KJY28859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949720.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000697.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5249"/>
    <dbReference type="EnsemblBacteria" id="KJY28859">
        <property type="protein sequence ID" value="KJY28859"/>
        <property type="gene ID" value="VR44_24340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.850"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="146"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="52511" checksum="5E38648A7E64B276" modified="2015-06-24" version="1">MADPKGFLTTPRETACTRPVAERVKDWNEVYVKGSLLPIISKQAGRCMDCGIPFCHNGCPLGNLIPEWNDYAYREDWSAAAERLHATNNFPEFTGRLCPAPCESACVLGINQPAVTIKNVEVSIIDQAWDNGDVTPQAPDRLSGKTVAVIGSGPAGLAAAQQLTRAGHTVVVYERADRIGGLLRYGIPEFKMEKVHINRRIEQMRAEGTKFRTGIEVGRDITATDLRKRFDAVVVAAGATVSRDLPVPGRDLKGIHFAMEYLPLANKVQEGDFMAPPITAEGKHVVVIGGGDTGADCVGTAHRQGALSVTQLEIMPRPSEDRPAAMPWPTFPMLYKVTSAHEEGGERIYSVSTTHFEGDEDGNVQALHLVEVEFIDGKLTQKPGTERVLPAQLVTLAMGFTGTDQSNGLVEQFGVELDERGNIARDASYATNADGVFVAGDAGRGQSLIVWAIAEGRSAARGVDRYLTGTSTLPYPVKPTDRSLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5U1</accession>
    <name>A0A0F4J5U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_25685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949968.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1583"/>
    <dbReference type="EnsemblBacteria" id="KJY28291">
        <property type="protein sequence ID" value="KJY28291"/>
        <property type="gene ID" value="VR44_25685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1236"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="43946" checksum="FD4EC39E610844CB" modified="2015-06-24" version="1">MHLEYTPEQQQLRAELRAYFAELVPQDVYARYEDPAAQKRFYRETIRRLGADGWLGVGWPKEYGGRGMSPMDQFIFFDEAAQAVVPLPLMALNTVGPTLMQFGTDEQKAYFLPRILSGEIDFAIGYSEPGAGTDLAALTCKAVREGDEETGTYVVNGQKIWTTNGDTADWVWLAVRTDPDAPAHKGITMLLVPTSDPGYSCTLINTLASHDTTASYYEDIRVPASRRVGQENKGWRLITNQLNHERVTLAAHGTMAIRALHDVQRWAAETKLADGRRVIDLAWVRARLARTHARLDAMKLLNWQMVNAVQSGTLTPQDASAVKVYGSEARRDAYAWLMEVVGAAGALKDGSAGAVLHGELERGYRSAVIFTFGGGNNEIQREIISWIGLGMPRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7V2</accession>
    <name>A0A0F4J7V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CopY family transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000608">
        <property type="protein sequence ID" value="KJY29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene129"/>
    <dbReference type="EnsemblBacteria" id="KJY29879">
        <property type="protein sequence ID" value="KJY29879"/>
        <property type="gene ID" value="VR44_21765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.233"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16249" checksum="29817E47CCB3CB6E" modified="2015-06-24" version="1">MTRVWQWNRPVTVREVLEDLQQERSIAYTTVMTVMDNLHQKGWVRREAEGRAYRYTAVSTRAAYSAALMNEAWSTSDNPAAALVAFFGMMSPEQREALRDAVRIVQHDEPEPPAADAAEAAPPAAGPGAGASAPREEGGSGAHRSEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J803</accession>
    <name>A0A0F4J803_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30335">
        <property type="protein sequence ID" value="KJY30335"/>
        <property type="gene ID" value="VR44_20730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8863"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="787" mass="85582" checksum="17BAE281AE9AE03B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J881</accession>
    <name>A0A0F4J881_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY29994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949178.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29994">
        <property type="protein sequence ID" value="KJY29994"/>
        <property type="gene ID" value="VR44_21425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.161"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470693" evidence="2">
        <location>
            <begin position="32"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="715" mass="76140" checksum="F90D206C79B27BA6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J957</accession>
    <name>A0A0F4J957_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000640">
        <property type="protein sequence ID" value="KJY29481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29481">
        <property type="protein sequence ID" value="KJY29481"/>
        <property type="gene ID" value="VR44_22825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10278" checksum="E62A9869634A4828" modified="2015-06-24" version="1" fragment="single">MDSRKTRPIADSIEDLIGSTPLIRLHFEDTAPGTQVLAKLEAANPMSTSKDRAALYMLRAAEGRGELTPGSGTVIEATSGNTGISLAALCAARGYRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J975</accession>
    <name>A0A0F4J975_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000574">
        <property type="protein sequence ID" value="KJY30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30308">
        <property type="protein sequence ID" value="KJY30308"/>
        <property type="gene ID" value="VR44_20780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8874"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="44280" checksum="8621587E5A368AB7" modified="2015-06-24" version="1" fragment="single">MTTVPLHDETMLLDDTARLRAAAAFVREHDSASLLPLLLPGIEGPDLRALAGHCHFAHAGILVFPPDEETLRARLGDCGLTFDAPSHPSVVVRERLARRHRLAPADLDVRILRPQVRGTDGERRAVEVFALTVPPHSGLERIAAPERTAGHEAHLAFEVDHPDPLVLRGLCAILARHGAHPDGGGYNPHEDGTVLYFTTPAEGVSGYRRLELYAHGDHRDSLAAHLDHTHPRLASPPAETLLHLLTGAWTTQALASFARLRLPDAMDTRTASTARDLARLTGTDPRGLATLLRYLAMLGAVTREELPEGLPEQLPEEFPEEGFRLTALGALLRADAPDSMRPLALMYGGPFYRSFGELDHAVRTGQPGFDHLHGENHFDHFARDPELADLFDRSMAASSRMFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA33</accession>
    <name>A0A0F4JA33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000611">
        <property type="protein sequence ID" value="KJY29836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949277.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000611.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29836">
        <property type="protein sequence ID" value="KJY29836"/>
        <property type="gene ID" value="VR44_21930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.266"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="19502" checksum="EB43E4D77E6570EB" modified="2015-06-24" version="1">MYFAALLARTEDGWEASDLELDDVESLSDLIDLARSAAVDDDTVVALIEQEDAWFGVIRVDGEEDPRYFVSNASAADRSSYGSMLTKELLGSVDEDDDLDELDLDGTEDGEDEPVASYTDEEDDADGTRTGSGAEPVPAGPLGDPRLLDDLGVGHKELMSLDGDALAEIADALGATEVLEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAE2</accession>
    <name>A0A0F4JAE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000499">
        <property type="protein sequence ID" value="KJY31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948616.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000499.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000063_gene1473"/>
    <dbReference type="EnsemblBacteria" id="KJY31342">
        <property type="protein sequence ID" value="KJY31342"/>
        <property type="gene ID" value="VR44_18375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8224"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="10808" checksum="1D95AD1FFCFCBE65" modified="2015-06-24" version="1">MSPLLRRKEKKRPEERMVTLVGKPGCHLCDDAQEVIEKVCAETGAQWEKKDISQDEELYRRHWEQIPVVLVDGEQHTFWRVNPDRLRKALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBI5</accession>
    <name>A0A0F4JBI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000513">
        <property type="protein sequence ID" value="KJY31164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31164">
        <property type="protein sequence ID" value="KJY31164"/>
        <property type="gene ID" value="VR44_18755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8362"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="23563" checksum="D0061E2CF1FA54E6" modified="2015-06-24" version="1">MSTGPAPHPEDASVLTEAERAAAARLPADRRADALAHRATVRRILGRVLEVPPGELEFGRRPCPGCADAGHGPPYVRHPDNTLWISISHTGGCGVLVVADHPVGVDVEHEARPWSPEAAAKALTPSERAHLDSQPTPQARARAFLTCWTRKEAALKAAGIGIVTDLAAVETHPAVPGPVTLHAPPPAPPTPWYTGPVPLPPPYLASLSRSTPTAHLRLHRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC91</accession>
    <name>A0A0F4JC91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000553">
        <property type="protein sequence ID" value="KJY30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948927.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000553.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1604"/>
    <dbReference type="EnsemblBacteria" id="KJY30591">
        <property type="protein sequence ID" value="KJY30591"/>
        <property type="gene ID" value="VR44_20050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8632"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="36906" checksum="B8B1B0379507BFED" modified="2015-06-24" version="1">MTTRYAREVAVVAFAQSDHLRRTDELSEVEMVMPVLHQVLAATGLKTGEIGFTCSGSSDYLAGRAFSFTMTLDGVGAWPPISESHVEMDGAWALYEAWVKIQTGEADTALVYAYGKSSPGSVRDVLTRQLDPYYLAPLWPDSVALAALQAQALIDAGETDEPALAAIGARSRAAAADNPHAQLRGAVPQGGYQVAPLRTGDCPPIGDGAAAVILAAGDTARRLCERPAWITGIDHRIEAHGLGLRDLTDSPSTRTAAERAGLFDAPVDTAELHAPFSSQEVVLRKALGLGGDVTVNPSGGALAANPVMAAGLIRIGEAAARIHRGESDRAVAHATSGPCLQQNLVAVLEGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCG8</accession>
    <name>A0A0F4JCG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948881.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3117"/>
    <dbReference type="EnsemblBacteria" id="KJY30676">
        <property type="protein sequence ID" value="KJY30676"/>
        <property type="gene ID" value="VR44_19810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8581"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="14"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22489" checksum="A20A7D5214C03F15" modified="2015-06-24" version="1">MSPQGRGIAKGDTFRILHVSTGNVCRSPITERLTRHALAHRLGALGLPSGDLIVESAGTWGHEGAPMEANAAAVLADFGADATGFTGRELLDEHVIRADLVLTATRDHRAQVISMGHSAGLRTFTLKEFTRLVRAIDPATLPPLDDGMAERARALVRAAAALRGWLLAPSADADEVYDPYGAPITFFRSIGDEINEALDPVVTALTGVTPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCL2</accession>
    <name>A0A0F4JCL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_16615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948283.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32092">
        <property type="protein sequence ID" value="KJY32092"/>
        <property type="gene ID" value="VR44_16615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7755"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="31268" checksum="FBBF5AF7963C37D4" modified="2015-06-24" version="1">MSAPTTPHPEGTAGGTTPRRRRRGPRTWLATLPLLVFTGFCFGIPLAAIAFGAVTRTDPATGATSVTGEHLARSLQGPYLGSLTGSVQLSALTALLATLIGVLIAQALVTSRSTALRSAALTASGVLANFGGVPLAFAFIATAGISGVVTRLADLTGLGWDLYSFTGLTVVYLYFLIPLMVLVTVPALDGLRPQWREAARNNGATGWQYWRHVGLPVLAPSLLGGFVLLFGTAFVAHATAAALVGGSVPLVTLKIADALSGNVLTGQENVALALGLDMILIAGLVMAVYLPLQRRSARWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM5</accession>
    <name>A0A0F4JCM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31483">
        <property type="protein sequence ID" value="KJY31483"/>
        <property type="gene ID" value="VR44_18055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8157"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="38158" checksum="A2E59E8D9F22DB20" modified="2015-06-24" version="1">MATALWGRAEQQDFRSRVRGTLLGSAIGDALGAPVAGLSLDGIRAAHGPAGPTGPAPAHGHRGTVTASTQLTLFTVDGLIRAHVRRDTGGWHPPTDVHRAYLRWAATQHDWGPDERRKDNGWLAQEEWLYARRGPERACLTGFADDTRGTPDQPKNPTARDAAATARSAPFGLLVGWEPSLVLQLAVECATQSHGHPTAYLSAGAFAVLVHGLMRGETLDAVLQRALALLAARPGHQPVTDALRRAVAAASGGTAESLSPGSPGEGGDAADTLAVAVHCALVAEDVPHGLRLAVNHGGDSSATGALCGALLGALHGETALPAAWLAELEGRPTILELADDFALEMTQGPALHGPAASAPGWLTRYPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM8</accession>
    <name>A0A0F4JCM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_19600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000542">
        <property type="protein sequence ID" value="KJY30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30741">
        <property type="protein sequence ID" value="KJY30741"/>
        <property type="gene ID" value="VR44_19600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8531"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="28532" checksum="D9C4947437031813" modified="2015-06-24" version="1">MGAPRGPGEAVRTAGDPRRISEGPRVSAPAPLLRRAVVEGLGTAALVAVVVGSGIQATELTHDVGTQLLANSLATVFGLGVLIAFLGPVSGAHFNPAVTLAAWFTGRRTGDGLDLRDVAACLPAQVVGAIGGAVLADAMFGKPLVAFSTHERWAGHLWLAEVVATAGLVWLIFGLTRAGRAHLAPLLVASYIGAAYWFTSSTSFANPAVTIGRAFTDTFAGIAPTSVLPFLAAQLLGAAAGLVLVAVCFGRPAAVGEDEAVVPPAGQQPTTRSTEESALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD02</accession>
    <name>A0A0F4JD02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000443">
        <property type="protein sequence ID" value="KJY32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948307.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000443.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32075">
        <property type="protein sequence ID" value="KJY32075"/>
        <property type="gene ID" value="VR44_16740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470825" evidence="2">
        <location>
            <begin position="29"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="509" mass="51056" checksum="C49E992346F65BE1" modified="2015-06-24" version="1" fragment="single">MRQRISLLAACGLVAAGLVTVPAAAAHAAEPVFRLVGTPVGLSLPPAPATGSPTPVALNYRLEGTAGATSFDGEFTLTVDLSMLNGVATVQESPRAAVKKCAPAGATLVCKQQGLHPGVPAGVDLEVTPGKKAGVGVVRVTGTAAGATVESGSTGIKVGAPDLVMGEMRLKKDLKPGETQPLPLTFSNQGNEPAKGIVLELEASRGLELPERYDNCTYRTTRTSTTAVCTVEGDFDPKASYELAGDSPLHLTAGANALNERFGYAVYPAPAPQKAQADAAKPGTDQSQAGGPADRAVRKLTARKAAPVAPVAEHGPDLNPADNKREAVLTVANTADFEALPLTVKGAAGTTAKAVVAIRNNGPAWIADQGGAPAAVVDVELPAGLKAVTAPAACRAVGDAHYRCATTPSVLESENAEFPFELKIEKAVKDAKGAIRVGAAGPKGEPQRHSFDPNLANNLAAFTANPTATGPSPSPSAGTASPSASTSASASPGTSASAGSTANGGRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE01</accession>
    <name>A0A0F4JE01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_17050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000450">
        <property type="protein sequence ID" value="KJY31968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948364.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000450.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7016"/>
    <dbReference type="MEROPS" id="M67.009"/>
    <dbReference type="EnsemblBacteria" id="KJY31968">
        <property type="protein sequence ID" value="KJY31968"/>
        <property type="gene ID" value="VR44_17050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7941"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15699" checksum="11E2467C406DFBE2" modified="2015-06-24" version="1">MLTLTQALYDQIVEHARKDHPDEACGVVAGPAGTGRPERFIPMLNAARSPTFYEFDSKDLLKLYRELDDRDEEPVIVYHSHTATEAYPSRTDVTYANEPGAHYVLVSTADTDGLGEFQFRSYRIVDGVITEEEVQVVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE18</accession>
    <name>A0A0F4JE18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_15645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000072_gene304"/>
    <dbReference type="EnsemblBacteria" id="KJY32597">
        <property type="protein sequence ID" value="KJY32597"/>
        <property type="gene ID" value="VR44_15645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY32597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="32445" checksum="6F4F15DE957B7043" modified="2015-06-24" version="1" fragment="single">MVEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPMPVQAVRWLAAGIAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQAKDSRSVKGASDVFSLGSTLVFAATGHPPYHGANPVETVFMLLREGPNLDGLPDELRPLIDSCMQMDATQRPTPADLQAQLAPHLFDGGDDSGTASAWLPARAVAMIEARRAGHRTPVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE23</accession>
    <name>A0A0F4JE23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31241">
        <property type="protein sequence ID" value="KJY31241"/>
        <property type="gene ID" value="VR44_18540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8303"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="33129" checksum="626CD1463B9BE3D0" modified="2015-06-24" version="1">MAAVGELDVVWSLPGEDVRAGWRALSWTARAEGGIAVLLVQKRFLERSYGVWHARERFDGEVVFVSGGGVVQRRTLVFGMDPWVGHFALLPGDRFLLVQGRTRQGDGGRWEPNAVVHGADGRGVERAFCVGDDIPALVTDRRGGIWTAYGDEGIYGHHPESGAGLAGWSSRGAATWAPAGRLPSQPLEGLTAATERDAVWLAWYSHEGTYLTRIVSATGEFATFRSPERGIDGLAVRGDRAVLTRRDHGEHTTTLTRAELADGTWTVTGREKLRLPGPLRLRCGQGRDGVLWLRAGDSWVRIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF91</accession>
    <name>A0A0F4JF91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000386">
        <property type="protein sequence ID" value="KJY32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32880">
        <property type="protein sequence ID" value="KJY32880"/>
        <property type="gene ID" value="VR44_15075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7433"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14849" checksum="F7DA34AC9A13A0CC" modified="2015-06-24" version="1">MVLVMVGLAAVVFTLGNLVEFLRMRALERRGIEGEAVSVVQDWMNHKYRVHYRVCLPEGGRDERFYEVGVEEPEPLGTVFPVVYDRKKPSRAKLGTRQNIDFATEGLIVKLAWGIGVPAIALGSLLIRFFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF98</accession>
    <name>A0A0F4JF98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000476">
        <property type="protein sequence ID" value="KJY31661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31661">
        <property type="protein sequence ID" value="KJY31661"/>
        <property type="gene ID" value="VR44_17680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8034"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="15002" checksum="795F8D25A70F0068" modified="2015-06-24" version="1" fragment="single">MPKPTPVTTRPSRSGGAQTAAALLRALLSLTVLALLLAGLPVLLWWATSLVGPPGVAALAHLLSTEDSGQVFLLVLAVAGWAGWACFTGAVLLEIAAQLRGRAAPQIRGLVGQRAAAALVGAVLLALPAGTALAAPSAAAPAPAAVGVSASPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGC3</accession>
    <name>A0A0F4JGC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS alpha-glucoside transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_14040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947811.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33402">
        <property type="protein sequence ID" value="KJY33402"/>
        <property type="gene ID" value="VR44_14040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7111"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="140"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="509" mass="51259" checksum="19F4EF5E19F907F8" modified="2015-06-24" version="1">MTPDKHRATAAAILPLVGGPDNIGSVAHCMTRLRLGLHDRSLVDEAALRAVPGVLGVVEDDATCQIVLGPGAVARVTPAFEALVTEGRTAPPTDPAPAEGRTAASAEPPGVTADELAARGAALRQARKARNATPFKLFLRRIANVFVPLIPALIGCGIIAGLGGLLANLGWVPALVPALAAIGSGFMSLIAVFVGHNTAKEFGGTPVLGGAVAAVVVFPGVAKVEAFGQHLSPGQGGVLGALAAALLAVRVERWCRRRVPQALDVLLTPTLTVLVPGLVTLYGLMTVAGALSTGIGTFADRLLATGGAVAGLVLGGLFLPLVMLGLHQALIPIHTTLIQQSGYTVLLPILAMAGAGQVGAALAVYCRLPHNPSLRATIRSALPAGLLGVGEPLIYGVSLPLGRPFVTACVGGAAGGAFVGLFNQLGVAFGSTAIGPSGWALFPLLKGTSGMAATVAVYAGGLAVGYLTGFAATYFFGFTRRMLTELNAAPAPATPPTTPDQPTEAPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ13</accession>
    <name>A0A0F4JJ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000309">
        <property type="protein sequence ID" value="KJY34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947512.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000309.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34185">
        <property type="protein sequence ID" value="KJY34185"/>
        <property type="gene ID" value="VR44_12405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6473"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9984" checksum="EC8E251497BE4F98" modified="2015-06-24" version="1">MLPLDPQADIGRRAWVPCPGCADTRDCEPCAERRTCSLHWRYLLSNKGSLLHLQCPGCTHVWTHETGFGATRSLWSRVTSGLPRPAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ84</accession>
    <name>A0A0F4JJ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000303">
        <property type="protein sequence ID" value="KJY34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34255">
        <property type="protein sequence ID" value="KJY34255"/>
        <property type="gene ID" value="VR44_12275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6438"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9004" checksum="908CDC54B27BD105" modified="2015-06-24" version="1" fragment="single">LDGAARLEVFAQLTGFVAGHVGYEIAQARAALPPGRAEAEARYLAAVAADGRHPELAEALASAGSPPTPDDTFARFLDRLVDGLDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJB0</accession>
    <name>A0A0F4JJB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_12210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000300">
        <property type="protein sequence ID" value="KJY34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34285">
        <property type="protein sequence ID" value="KJY34285"/>
        <property type="gene ID" value="VR44_12210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6423"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22049" checksum="405B143918DADF64" modified="2015-06-24" version="1">MMTVARPRGVDDLAILRAATEVMGRVGPAGLTLAAVAREVGLVPATLTQRFGSKRGLLLALADRSVEDAGARIAQVRAAHGSALGALSELVTETMAGMATPERFANHLAFLCMDLTDPQLRERALAVHRAQTRAVVELLAEAVAAGELRAGTDPAALARTVQAVAAGTGMHWALEGEGDLGRRLRHELDAVLSPHLPARPPRPEEAASAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJI8</accession>
    <name>A0A0F4JJI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947425.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34380">
        <property type="protein sequence ID" value="KJY34380"/>
        <property type="gene ID" value="VR44_11955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6476"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="33486" checksum="BBCCFB190E5EFD57" modified="2015-06-24" version="1">MDLDTVRTFVAAAEAGQFQEAAAELAVTQQAVSKRIAALERALGVRLFTRTPRGAELTIDGQAFLPHARELLRTAERAVASVRTDRRPLRVDVINSRGAATGLMREFHRAHPEIELDVVMLLEIDTAVAAIRSGAIDASFRAVAAPGRPLPEDVEAVRVLDEPLQLLTGPAHALAGARSVTLAELAGHRIWMPGVVPGTEWTAYYDDLVAEFGLTIEATGPNFGSDALLDTIADTPALATFMSERTRLVWPAGHGLRRIPVTGPTPVYPHALLWRRDNPHPGLAALRAHLAGAAGGRDTAGTWMPDWVIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKG0</accession>
    <name>A0A0F4JKG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000270">
        <property type="protein sequence ID" value="KJY34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947342.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000270.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34680">
        <property type="protein sequence ID" value="KJY34680"/>
        <property type="gene ID" value="VR44_11505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8699" checksum="AC20F80E43523DA6" modified="2015-06-24" version="1">MDRFFAIPMGLIGITFPLFKFGTESVRNSLGWPCLGCGIALTAAGLLYCAWSRRSPGWGGLSCGIGASIVGLLAFARYGPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKJ1</accession>
    <name>A0A0F4JKJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_12065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000294">
        <property type="protein sequence ID" value="KJY34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947446.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000294.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34344">
        <property type="protein sequence ID" value="KJY34344"/>
        <property type="gene ID" value="VR44_12065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6498"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="482" mass="49534" checksum="CD11AD424DEF96F1" modified="2015-06-24" version="1" fragment="single">PPPGGTRPLRKRFVLTAMGCAGGLIMLDQTVVAVALGPMARSLGLTTWVMHRVVLVYVLALSAFAPVGGMAARRFGLLGTFRCGIVLFAVASGACGLTPAGDAAAPFLLLMRALQGVGAGLMIPVATTVITNVYEEHERGRALAVYAGLAQVFFSLGPVVGAVLTQYLGWRSVFPAGVPVAAAALWLAARAGVEEERGRGALTVVQPVAVIASVGAVVLALYQCGIWGLADPRTPAALTAAAAALVLAVRLVLRSREPLVNLRLLRIRPYAVATALTFLVQGPQLIVMVHGTLFLRQAMHLPPLTTGLALLPLVGALTTGTFLSGHLLDRHRSIRVPVLLGLTAATLGAALWTAALPSRAYLWQVPGMVLAGIGMGMPVPALSAELMRAVPQHDRADASVLRQTLRQLGGAVGLALAGALVLAANDDTADAAGIVTATATPVAFVTADAFLLAALLSATALLPVRAPAKVAPAGRGPAHHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL67</accession>
    <name>A0A0F4JL67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947377.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34508">
        <property type="protein sequence ID" value="KJY34508"/>
        <property type="gene ID" value="VR44_11705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="37741" checksum="E91808B32C231027" modified="2015-06-24" version="1">MADTPQLWMRSETRPTERRAPLTPDDAGLLVRQGVRITVEDSGHRVFPLDAYAAAGCRTAPAGSWAQAAPGSAYVLGLKELPPAPEALHHRHVYFGHAYKGQPQAPGLLRRFAAGGGTLLDLEYLADAQGRRLAAFGYWAGYAGAALAALQARGRLTAPLVPTPRPELDARLRDAPADGLRALVIGAEGRSGRGACDALTTAGIAVTRWGRGATRRLDRAALLDHDILVNAVLTTRPVPPFLTPADLESGTGRLSVIADITCDTGSELHLLPVYDRLTDWTAPARRLRGGARPVDVIAIDNLPSLLPAEAARAFSADLLPKLVDLHSPAPDPDWLRCRAAFTTAMEALTGPDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLT3</accession>
    <name>A0A0F4JLT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947187.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35150">
        <property type="protein sequence ID" value="KJY35150"/>
        <property type="gene ID" value="VR44_10680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5883"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470851" evidence="4">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_5_C" evidence="6">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="472" mass="52090" checksum="A347DBB76338FBEE" modified="2015-06-24" version="1">MRRTSRSAPVALAVAALLLGVLPAQARADSGRAPDRVTVGGRTFIADGQGRALQWRGFNLADKRGRGADAFADIHESDLRDMAARGFNLARLAFFWDDLEPAPGRYDRGYLAKMRRILDWADRYHVKVVLDAHQDVYGPHFGSRGVPDWATRDEGLPFSPVPDDWFSEYFEPSVQTAFDHLYKDGDLRAAHARMWVTVASALGGHPALLGYDLMNEPFAKFLEGEDLPAAAARFEAGELTEMWNRLARAVRLVDRKSWVFVEPTVIVGLGVPTRLGRIDDPHAGYAPHFYETAMETGADYDPHGPFIPAYEAAISDYPTRNRMPVIVGEWGGNPYVAHASQFVTDMTASLDRFSSGWTWWQWCRGGGYCFLDQAGAAKPSARLLVQPYARAVAGDPLGFAYDPAARTYTLTFRTRDNAGGPTQITVPGDTYPNGYRVTVRGGDARWDGHGQTVTVNTRGRAGTTYEVTIGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM02</accession>
    <name>A0A0F4JM02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947110.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35382">
        <property type="protein sequence ID" value="KJY35382"/>
        <property type="gene ID" value="VR44_10275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5923"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="24212" checksum="832081AAFC7C6E5A" modified="2015-06-24" version="1">MAKIESELIRRWLHGWTVARSLPEAEPVESTGDGLRSECGQPGREVEVFALRADEEPESLARLAAAVAAAKQTTWLTVPTLHPSAVEALVSAAGLELLHRSEWFMTTDLTEHPQHAPAAPYQREVRTEGPVTVVSLHGPSGEVAARGAIAVVGADAIADRIETSPAHRRRGLGRAMMSGLAEAAVAQGARTGLLIASEEGQRLYSSLGWHHEADVLIARGPAVPPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMD5</accession>
    <name>A0A0F4JMD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34106">
        <property type="protein sequence ID" value="KJY34106"/>
        <property type="gene ID" value="VR44_12610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6588"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="17963" checksum="6E872DB1B419CE28" modified="2015-06-24" version="1">MTAEWLNDQPQVRPYVADPALPDAVMCDIDGTLALTGDRGPYDFSRCELDLPNEPVRHALAAFRRGGDRIVLLSGRGEEHRPQTESWLRAHEVPYDELWMRAAGDTRRDDVVKAELFDAHVRERYAVRVSLDDRDRVVAVWRRMGLPTWQVNYGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMU3</accession>
    <name>A0A0F4JMU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000242">
        <property type="protein sequence ID" value="KJY35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947209.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000242.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35144">
        <property type="protein sequence ID" value="KJY35144"/>
        <property type="gene ID" value="VR44_10780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6006"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="35"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="240"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="719" mass="76669" checksum="5CB5C76398DD3512" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNG7</accession>
    <name>A0A0F4JNG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35384">
        <property type="protein sequence ID" value="KJY35384"/>
        <property type="gene ID" value="VR44_10290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5927"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17869" checksum="3C07B23E2108C394" modified="2015-06-24" version="1">MMELVRASLMPVGNEPVPRTELPACRTVLKVARSTEDLDGMHPIHDLAAAAGVAASAMTFWLAQERDMDAAKALERMPGEGVQGPVVDLLRTLMTGPKGMGQTAEWLMRLFVRDQEAYLDLIVELGAYTATCIQILDGLGASSVDQSLEDLEDLLRDYYGDSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPH4</accession>
    <name>A0A0F4JPH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946978.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35653">
        <property type="protein sequence ID" value="KJY35653"/>
        <property type="gene ID" value="VR44_09560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5313"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="146"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="31899" checksum="3830B2E4056F87E8" modified="2015-06-24" version="1">MKSSRTVVDSALTALAPAIWGSTYLVTTELLPEGRPLLASLLRALPAGLILVIIGRKLPKGIWWWRALVLGVLNIGAFFYLLFVAAYHLPGGVAALVMSIQPMIVLLLGAALLKDKIKPIHLVSCALGAAGVALLVLQPNAGLNATGVIAGLLGALSMASGIVLTKRWGRPEGVGLLPFTGWQLTVGGLVLLPIALIGEGLPSEITGKNLLGFAYLGLIGALFAYAIWFRGVARLPALAVSFLSFASPLAATLLGYFVLDQSLSPIQLLGALTVVASVILAQPRKPKAKPEAEPVRQTSRESVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPI0</accession>
    <name>A0A0F4JPI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="5" type="ORF">VR44_08545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946791.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene969"/>
    <dbReference type="EnsemblBacteria" id="KJY36085">
        <property type="protein sequence ID" value="KJY36085"/>
        <property type="gene ID" value="VR44_08545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4851"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21663" checksum="E855ACF3944CBA0D" modified="2015-06-24" version="1">MDVTPAAVTPEPVSLPEPRRLGVLSRLAPEPMKVVLNWGRRYSLWVFNFGLACCAIEFIAASMARHDFIRLGVIPFAPGPRQADLMIVSGTVTDKMAPAVKRLYEQMPEPKYVISFGACSNCGGPYWDSYSVTKGVDQIIPVDVYVPGCPPRPEALLQGILKLQEKIARESLAERYADRPSVAQLTSGLVTPPPAPGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ14</accession>
    <name>A0A0F4JQ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000247">
        <property type="protein sequence ID" value="KJY35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947237.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000247.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35011">
        <property type="protein sequence ID" value="KJY35011"/>
        <property type="gene ID" value="VR44_10950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6073"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="27750" checksum="D9FCB803D5F2D883" modified="2015-06-24" version="1">MEHFATNLIDRSAPESLLVVAAHPDDIEFCVSGTVMRWIAQGTQRVTYCIVTDGGAGGYDERLPRQAMGDLRRAEQVHSAKRSGVDDVRFLGYEDSYVEPSVELRRDLCRVIREVRPQRAVIPSPEINWSRIADLHPDHRAVGDAALRAIYPEARNPFAHPSLLKEEGLEPWIVPELWLMTGPTPNQYVDVTPVFDRKVEALRIHTSQTAHFDDLAGLLRDWLGDHARAAGLPAGRMAEAFQVVQIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRW4</accession>
    <name>A0A0F4JRW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946620.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36574">
        <property type="protein sequence ID" value="KJY36574"/>
        <property type="gene ID" value="VR44_07640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4140"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="32918" checksum="7678023810B90CDB" modified="2015-06-24" version="1">MDHHLDQRAELGDFLRTCRARLRPEDVGLPDHGRRRRVPGLRREELAQLAGVSVAYYTRLEQGHGHNVSAEVLDAVARALRLGEVETAHLNHLASPRIRRGGRARRPQQVRPELRTLMDAMEGVPAYLVGRRQDVIGWNRLAAAVFGDFGAHPAAERNLVRLVFLDPATAELYADWECRACEVVSNLRLYAGQHPDDEQLTALVGELSVKNEEFRRLWAAHTVADKTHGVKRLRHPLVGELELSFETLTLPDDPAQFLVTFHAAPGSPSADALRLLSSWTAPMPPPSAPAPAEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSZ5</accession>
    <name>A0A0F4JSZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946506.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36893">
        <property type="protein sequence ID" value="KJY36893"/>
        <property type="gene ID" value="VR44_07010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3616"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="32782" checksum="C5ACE41E8925DC21" modified="2015-06-24" version="1">MHELPQQLVNGLLLGSMYGLVAIGYTMVYGIVQLINFAHGEIFMTGGFGALTVWLMLPGGTTMWIALPLMLIGAVIVATLIAVGAERFAYRPLRSAPRLAPLITAIGLSIVLQQVVWAWFPDAKSSVKFPELPGGPFHIGSITIQTGDVFLLIAAPISMAFLGFFVKKTRTGRGMQATAQDPDTAKLMGINTDRIITIAFALGAAFAAIGAVAYGLKYGEVNYRMGFILGLKAFTAAVLGGIGNIYGAMIGGLVLGLAETLTTAYIADVPGMQQLGGQSWGNTWAFVLLILVLLFRPQGLMGERVADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTT4</accession>
    <name>A0A0F4JTT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37158">
        <property type="protein sequence ID" value="KJY37158"/>
        <property type="gene ID" value="VR44_06370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3183"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19839" checksum="978FBC3C1342F301" modified="2015-06-24" version="1">MRRLADEIAAITPSDRKFKVEIDGPEILTTLMSPTTAHGMIVLRLRRQIERQTPEMAALNDTNMENPRVEKLRIPDLMALPEDALDPSSDAVDAELVELVAEVVSKTNPENDYVKELAAYPAMGIPTYLLIDPREGLVTVYSDPVGGSYRASHTYSFGEKVEAGRWTIDTGDFPRYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTT8</accession>
    <name>A0A0F4JTT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000093">
        <property type="protein sequence ID" value="KJY37777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946134.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000093.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37777">
        <property type="protein sequence ID" value="KJY37777"/>
        <property type="gene ID" value="VR44_05000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1315"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="19035" checksum="5A7922BAE33A5E00" modified="2015-06-24" version="1">MAHPTQEIAGDERGTLLLFVEDQREALRRAATGLTAEQAASRPTASELSLAGLVKHAAEVELNWLRMAQQKPNEHRRAPEDWHEGFRLAEGETLESALAFWDTVKEETTGFIESVPSLDDDFPLPPAPWFPQDATVSMRWMLLHLVREFARHAGHADIIRETLDGTKAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX3</accession>
    <name>A0A0F4JTX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AtrA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946339.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37284">
        <property type="protein sequence ID" value="KJY37284"/>
        <property type="gene ID" value="VR44_06130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2562"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="66"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="315" mass="32772" checksum="CAC93FA75940814D" modified="2015-06-24" version="1">MTASTTRRTTAARSRIAAVGAIAVAGALILTGCGDQTNKSSSGTGAGDSSAPLFSKLPKKIQDAGVIKVGSDTAYAPMEYVDNGKIVGVDPDIAEALGKQLGVKLQFTSGTFDGLITSLETGRQDVAISSITDNKKRQEGLDDKGQKIGKGVDFVDYMSSGVSLLVKKGNPDNIKSLDDLCGKTVAVQRGTIYEDTFKAQAEKCGDKKLTIEAFDTDAEAQTRVKAGGAVADLNDFPVTSYIAKTSGGGNDFEVGGQQSDVGLFGIAVSKDNTQLRDALKEAVDAIIKDGSYAKVLEKWNVKDGAVQSATINAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU22</accession>
    <name>A0A0F4JU22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000109">
        <property type="protein sequence ID" value="KJY37334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946297.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000109.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37334">
        <property type="protein sequence ID" value="KJY37334"/>
        <property type="gene ID" value="VR44_05890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2220"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471036" evidence="2">
        <location>
            <begin position="33"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="46522" checksum="FBCA0A1D8FA29FD2" modified="2015-06-24" version="1">MSRYGRTPSRTLRLACALTLAGLAAALGPAAAATPRAEPAAAGGLREVLLVGNNWEGTADVLASTGDLARVGRIDVIPDKEERLREIYLNPVKLGFFLGIRATAGEGHDQFADDMYTTPDGTAVVVSRPSFADVVSVDLRSGRINWRFPVAGYRADHMAVSPDGTRVAVSASTANTVHVLDIATGRQLGSFPTGDKPHENTFTQGGRLLWNSSIGDVTSALDAPWLDWTKGDRRLTVVDAQTFRTVRTVDMRERLDAFGRKDLSDAVRPMVFTPDESKLYFQVSFFNGLVEYDVAADRVTRVKTLPENPATSPDRTTWVNDSRHHGLSVSPDGAKLCVAGTMDDYATVVDRATLAEGPLIPADKPYWATVDGDGKGCVISESGADRVTAIDFATGTKRVSVPVGDHPQRVRLGRVPADWTGPGARQAPAPVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUB1</accession>
    <name>A0A0F4JUB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000151">
        <property type="protein sequence ID" value="KJY36556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946648.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36556">
        <property type="protein sequence ID" value="KJY36556"/>
        <property type="gene ID" value="VR44_07760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4255"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="23694" checksum="516FDB7CB998BF8E" modified="2015-06-24" version="1">MPRVLIVDDHPLFREGLRAALESSRCALVVAEAETGGEVPDAVEAHRPDVVVMDLSLPDVSGIEVTRRLAASHPGLPVLMLTMSDDDGSVLAALQAGARGYVVKGAGSEEVLHALRTVAAGGAVFGSEIAARLSALLTSGHRRDAGRLFPALTAREAEVLELVARGHDNRRIARELVLSEKTVRNHVTHVFEKLQVTSRAEAVARARDAGLGEDGRTAPDGTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUZ5</accession>
    <name>A0A0F4JUZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946171.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37659">
        <property type="protein sequence ID" value="KJY37659"/>
        <property type="gene ID" value="VR44_05215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1676"/>
    <dbReference type="eggNOG" id="ENOG5033TW2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="18590" checksum="0DAFAC9AE9795855" modified="2015-06-24" version="1">MADHATHDAQARASLHLLVRDIERVRRQVDALRTLTAQLGNVYRPRRSGPSTGFVVYGRAPAPTVRLAQELRDSVETLVTAAVDFDRSLGFSWDAVGSALGVTKQAVHRRYGARRAQAAEAAEPLAEGTTTRTLGPLPTIPAARSVPPQPVREDSQAAAAPGPRQSAFPGPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV83</accession>
    <name>A0A0F4JV83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946499.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36886">
        <property type="protein sequence ID" value="KJY36886"/>
        <property type="gene ID" value="VR44_06970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3609"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24360" checksum="3AE766676E6B8B41" modified="2015-06-24" version="1">MDGAVEWFSIGELARRSGLAVRTIRFYSDEGLVVPAGRSGAGYRLYDVGALVRLELVRTLRELGVDLPSVRRVLDRELSVAEVAAVHADAVEAQIRVLRLRRAVLRLVAERGSSAEEVRLMHEVTRLSAQERRRLVEQLVEGAEESVAAMVRVAAPDLPDDPSAEQVAAWVELVGLMGDEGFGEVFRAGPGVEGPVDARVERYWRLVWAVNGWEVVPGWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVH9</accession>
    <name>A0A0F4JVH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroquinate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene160"/>
    <dbReference type="EnsemblBacteria" id="KJY37758">
        <property type="protein sequence ID" value="KJY37758"/>
        <property type="gene ID" value="VR44_05075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1330"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="14031" checksum="805495206321801F" modified="2015-06-24" version="1">MERGDFDALSALWLEDEISCVHPGWPVLSGRGEVLRSYALIMSHTEYIQFFLTDTKVALIGDTALVTCTENILSGGPAEEAGELGPLVGQLVVATNVFRRTPEGWRLWSHHGSPVLTDSDDEEEEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW57</accession>
    <name>A0A0F4JW57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946357.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000116.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37216">
        <property type="protein sequence ID" value="KJY37216"/>
        <property type="gene ID" value="VR44_06220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7991" checksum="57300D97A55F89C2" modified="2015-06-24" version="1">MPATTHTPSLPARAVRRRPGAYAHSGARLHWWTLALPALAFGLLLLLLAGSGQAQATADRPAGLVEVTQELLRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWT5</accession>
    <name>A0A0F4JWT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_03150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38600">
        <property type="protein sequence ID" value="KJY38600"/>
        <property type="gene ID" value="VR44_03150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="24100" checksum="CC7A1AA8DC37AFDE" modified="2015-06-24" version="1" fragment="single">MEQLHPSDPHHIGPYRLLSRLGAGGMGQVYLARSDRGRTVAVKLVHPGLAAREEFRSRFRHEVAAARRVGGTWTAPVLDADTEAHIPWFATGYVAGPSLRQAVAHDFGPLPGRTVRILGAGLAHALQDIHRAGLIHRDLKPSNVLLTLDGPRVIDFGIARPLEDHTGGMTRTGELVGSPGFMAPEQVRGETVTSACDVFCLGAVLAYAATGRLPFGDAERSGGAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX94</accession>
    <name>A0A0F4JX94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945894.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5775"/>
    <dbReference type="EnsemblBacteria" id="KJY38444">
        <property type="protein sequence ID" value="KJY38444"/>
        <property type="gene ID" value="VR44_03685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8275"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="21419" checksum="4CBAB5093F97BE77" modified="2015-06-24" version="1" fragment="single">ARICQLDEYVGLPAGHPESYRAVVLREVVEPLGLTEDSFMGPDGSAADVQAACEAYDQALAEAGGVDLQLLGIGTDGHIGFNEPCSSLASRTRIKTLTQQTRVDNARFFDDDIAQVPHHVITQGIGTILDARHLVLLATGEGKAEAVAQTVEGPLSALVPASALQLHRHATVVVDEAAASKLKLADYFRHTYANKPVWQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXS6</accession>
    <name>A0A0F4JXS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1883"/>
    <dbReference type="EnsemblBacteria" id="KJY38930">
        <property type="protein sequence ID" value="KJY38930"/>
        <property type="gene ID" value="VR44_02680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6842"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14433" checksum="2516B4CA19A10C6C" modified="2015-06-24" version="1">MVDLDSNPTKLIEIVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAVVYPGLDKLNIMGLASPESAILSAVIFNALIIVALVPLALKGVQYKPTSADRMLRRNLGVYGLGGLIAPFVGIKLIDLLISLIPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZK7</accession>
    <name>A0A0F4JZK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000029">
        <property type="protein sequence ID" value="KJY39153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39153">
        <property type="protein sequence ID" value="KJY39153"/>
        <property type="gene ID" value="VR44_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16532" checksum="B53FF6ACCC1685C8" modified="2015-06-24" version="1" fragment="single">MRVLDVRWHSLAETFRLCWEEARPIVQVAFLLRFAVGVVSVGQLPQSLGRPVLGMASLWCAVVCAYLLNGVTDVHEDRVNGSRRPIARGDLPERTAARGTVLLACAALLLGGLAGPSVVAWTAAFLVLGWAYSADPVKAKCSSGRCAAVVFGLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZM0</accession>
    <name>A0A0F4JZM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_03630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945886.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5764"/>
    <dbReference type="EnsemblBacteria" id="KJY38436">
        <property type="protein sequence ID" value="KJY38436"/>
        <property type="gene ID" value="VR44_03630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8264"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="38903" checksum="1FA5762DD143F9A1" modified="2015-06-24" version="1">MTAEKKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLHSDVADLAKLTPAEQHMIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPDDRAAAFDAVENIPSIREKAQFCFKWMDSVEKIDKLETAADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMNFAFEVVDTVRKEEPELFDDALQQQVTDMLKEAVEAELQFGRDLCGDGLPGMNTDSMREYLECVADQRLVRLGFPPVYGSQNPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K066</accession>
    <name>A0A0F4K066_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_01440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945484.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39494">
        <property type="protein sequence ID" value="KJY39494"/>
        <property type="gene ID" value="VR44_01440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4720"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="36898" checksum="58EFE474B30C3688" modified="2015-06-24" version="1">MATDLFGRSFLKELDFTAAEFRGLVELAAELKAAKKAGVEERRLQGRNIALIFEKTSTRTRCAFEVAAADQGAHTTYLDPSGSQMGHKESVRDTARVLGRMFDGIEYRGDSQQAVEELAAYSGVPVFNGLTDDWHPTQMLADVLTMTEHCAKPLERIAFAYLGDARFNMGNSYLVTGALLGMDVRIVAPKEYWPAEAVVARARELAASSGARITLTEEVAEGVAQADFVATDVWVSMGEPKEVWDERIAALAPYAVTMDVLHATGNPDVRFLHCLPAYHDLGTKVAREVHERHGLEWLEVSDEVFESAHSVVFDEAENRLHTIKAVLVATMAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0L8</accession>
    <name>A0A0F4K0L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_00910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000013">
        <property type="protein sequence ID" value="KJY39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945383.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39659">
        <property type="protein sequence ID" value="KJY39659"/>
        <property type="gene ID" value="VR44_00910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2892"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="25159" checksum="BD09E2E1F2433F6F" modified="2015-06-24" version="1">MDEAATVGRSDQELLSLHVAGDPDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAYRAAHTFRGDSAVTTWLHRITVNACLDRARKAASRRTAPLDDTDRLERLLEPHESAEAPAERQDLHRQLLAALATLPADQRAALVLVDMQGYPVAEAATVLDVPVGTVKSRCARGRAKLLPLLTHLRTNAGDNTATERGRNRTPGAPVPSAADPRHPEPDPDPVKGGGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1D2</accession>
    <name>A0A0F4K1D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945326.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39738">
        <property type="protein sequence ID" value="KJY39738"/>
        <property type="gene ID" value="VR44_00580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2822"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="135"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="39055" checksum="D3BA37361CE433D2" modified="2015-06-24" version="1">MGTTARRALVIGGGIGGLAAALGLHRTGWEVRVLERAPVLEDAGAGISLAANGIRALDALGVGTAVRAAAHPQYTGGTRTPDGRWLSRMDGRALERALGTPMAGIPRATLHRLLREALPAHCLRTGSGTLATDPDADLVVAADGLRSAIRTGLFPDHPGPVYSGSTVLRAITAEPVRTDEDFALTWGPGAEFGHIGFADGRAEWHAVLKAPAGIRHPDPLRVLGRRFANWHPQVGRLLAATRPEDVLHHDVHELVTPLPAYAVGRVALLGDAAHAMTPNLGQGACQALEDAVVLAAELAGGGPVAAALSRYDAVRRPRTQAVARAARRAGRMGHALTHPLAVSARDTALRLAPSGATVRAILRPATWTPPALPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDY1</accession>
    <name>A0A0F4IDY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001511">
        <property type="protein sequence ID" value="KJY20250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952381.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20250">
        <property type="protein sequence ID" value="KJY20250"/>
        <property type="gene ID" value="VR44_38750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5434"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="31985" checksum="3DBE5820CC1B1922" modified="2015-06-24" version="1">MTPITSVEGRRIALSNLDKVLYPRTGFTKGEVLHYYATIAPALLAHIHDRPVSFLRYPDGPDGQLFFTKNPPPGTPAWVKTAPVPRSEDPGAEQVLVSDMPALIWAANLVVEFHVHQWPASTPAVADRLVLDLDPGPPATVVECCAVALWLRDRLAADGLHAYAKTSGSKGLHLSVAVEPAPSARVSAYAKRLAQEAEAALPDLVVHRMAKALRPGKVFVDHSQNAAAKTTAAPYTLRARALPTASAPVTWAELRSCKDPSDLLFLADDIPPRLERDGDLLAPLLDPAQAGTLPGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHA0</accession>
    <name>A0A0F4IHA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001523">
        <property type="protein sequence ID" value="KJY20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952404.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001523.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20016">
        <property type="protein sequence ID" value="KJY20016"/>
        <property type="gene ID" value="VR44_38870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5489"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="33454" checksum="5FFA64E1B78CFC97" modified="2015-06-24" version="1">MARPRELLFRAALPTVLWLAVLTLFALFAEHTFRLLNGDSPLEDLGELLDSTPTAGFRADLPATLLFGLLWILGLLLISLLVSRRAPLPAGLLRFHTAVRPAAFATAVLLVGYVVLGLVIGLVVAGTQGHATRTLAVLLLGLPNLAWLGLTLGFGGAWQGRVEGPFGLPVPQLLDRVLRGPDLSTLDVSTLARQDGRAWWLVVVAALALLGTGVLTAARSPAGVRPWQHALHLGVALALATLAVCLLGRIEAQFGLSLLGIGDDSGLGGKVELTAVLWRTTGLGLLWGAVAGFLGAFLARPLHHPGPVDEPAPAHQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHV8</accession>
    <name>A0A0F4IHV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001512">
        <property type="protein sequence ID" value="KJY20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952384.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001512.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20246">
        <property type="protein sequence ID" value="KJY20246"/>
        <property type="gene ID" value="VR44_38765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5437"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045513">
        <property type="entry name" value="DUF6479"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20087">
        <property type="entry name" value="DUF6479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14049" checksum="B646BCA11FEE3C16" modified="2015-06-24" version="1">MDMILSVDATLSRSAWFFIVGIVVAGFLLAGFKLGQRVRAKEPPPPTPESQPHLPDGGPVHEVREERDQVEIPEGGLRPHEMQGYGNFGSTTSAHPDEVRAERESGYKRVTGPGPHPQPGAPPDAGRGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INV2</accession>
    <name>A0A0F4INV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001426">
        <property type="protein sequence ID" value="KJY22306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22306">
        <property type="protein sequence ID" value="KJY22306"/>
        <property type="gene ID" value="VR44_37980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5161"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY22306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8087" checksum="523A48A50491E247" modified="2015-06-24" version="1" fragment="single">VFTEAERAALELAEEATRIADAAGGVSDEVWANAAKHYDEDQLAALVTQVAVINAFNRLNVTVQQPAGHYQPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQA9</accession>
    <name>A0A0F4IQA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001269">
        <property type="protein sequence ID" value="KJY24210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951868.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001269.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5585"/>
    <dbReference type="EnsemblBacteria" id="KJY24210">
        <property type="protein sequence ID" value="KJY24210"/>
        <property type="gene ID" value="VR44_36010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4360"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="28653" checksum="A3FDC7B9AA166D0E" modified="2015-06-24" version="1">MKLRDLVYKLYARRVEGRLDHDASPKHIGVILDGNRRWAKASGSSTVQGHQAGADKISELLGWCTETDVEVVTLWMLSTDNLDRPEGELLPLLNIIENTVRGLAEDGRWRIHHVGNLDILPSRTQTVLKEAEQATHDIGGILVNVAVGYGGRQEIADAVRSLLLEHAEKGTSFEELAEVLDIDHIAEHLYTRGQPDPDLVIRTSGEQRLSGFMLWQSAHSEYYFCEVFWPAFRKVDFLRALRDYAARHRRYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRT8</accession>
    <name>A0A0F4IRT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001179">
        <property type="protein sequence ID" value="KJY24707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24707">
        <property type="protein sequence ID" value="KJY24707"/>
        <property type="gene ID" value="VR44_34540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3892"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="18168" checksum="679DECEDCEDEA2D8" modified="2015-06-24" version="1" fragment="single">YGTPRLVERLNEDWYALAVASGLFDERREFLVQLPQGTRTHDAAVRQLHGGRVVAPWLWTRVRLLEHWDVMGRGAASAFLGIRAGHPGFGMMALDGGVYLACSTGERGVDVLAVPRPDRSENVLRHLEEIVLRDSPHVGREYKDRIAGWLRGRSPAPPGAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS72</accession>
    <name>A0A0F4IS72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001156">
        <property type="protein sequence ID" value="KJY24870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24870">
        <property type="protein sequence ID" value="KJY24870"/>
        <property type="gene ID" value="VR44_34125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3751"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14606">
        <property type="entry name" value="Lipase_GDSL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="170"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="401" mass="41994" checksum="A5DFBAC504C75E6C" modified="2015-06-24" version="1">MTTPVTADLLRGALDTERTGRGLLPHRLPARARAQNTDGQLALAESQPSGVRLAFRTAATVVELDTVPVKRVYAGAPARPDGVYELLVDGRPAGRAGASGGDTLTIDPATGATAHRTGPPATLRFAGLPGRMKDVEIWLPHDETAELSVLRTDAPVTPVPDRGRRVWAHHGSSISQGSGAAGPTATWPALAASLGGVELVNLGLGGSALLDPFTARALRDTPADLISLKLGINLVNTDLMRLRAFGPAVHGFLDTIREGHPATPLLVVSPLLCPIHEDTPGPTAFDTAALSAGKLRFRAAGDPAERASGKLTLTVIREELARIVRQRAAEDPYLYHLDGRELYGEADAAGLPLPDALHPDADTHRRIGERFAALAFAEGGPFGPGGAPGDRARPAGQRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITH2</accession>
    <name>A0A0F4ITH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fusA</name>
        <name evidence="3" type="ORF">VR44_36705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001319">
        <property type="protein sequence ID" value="KJY23976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23976">
        <property type="protein sequence ID" value="KJY23976"/>
        <property type="gene ID" value="VR44_36705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4651"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="11"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="43386" checksum="D1B8C4211416E3BA" modified="2015-06-24" version="1" fragment="single">MRTRIDTNPLTAVRNLGILAHVDAGKTTVTERILFATGTIHKRGEVHDGTTVTDFDAQERARGITIFAAAVSCAWDGHRVNLIDTPGHVDFADEVERSLRVLDGAVAVFDAVAGVEPQSESVWRQADRHGVPRIAFVNKLDRAGADLDTAVASIRDRLGAVPLVVQLPVGREDAFTGVVDLLRMRALLWGAGADSYETAPVPESLLEEAVRRRRLLEETVAGLHADALEEFCATGSLGEATLVRALRELTLAGEGVVVLCGSAYRNRGIEPLLDAVVAYLPSPADMPAVQGRPADPAQPLAALAFKVTATPTGRLTYVRLYAGTLRKGDTVLDPGTGRTERIGRILRVQADRHEEREEAVAGDIVAVIGPKAARAGSTLCAPGAPLLLEPPAVADPVVSVAVEAGRSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW1</accession>
    <name>A0A0F4ITW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">tdh</name>
        <name evidence="9" type="ORF">VR44_36250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001286">
        <property type="protein sequence ID" value="KJY24131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951914.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001286.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1574"/>
    <dbReference type="EnsemblBacteria" id="KJY24131">
        <property type="protein sequence ID" value="KJY24131"/>
        <property type="gene ID" value="VR44_36250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4496"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="8">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="7">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY24131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="36546" checksum="8648D572789E89AF" modified="2015-06-24" version="1">MKALVKHKAEPGLWLMDVPEPEYGPGDVLIKVLRTGICGTDLHIRAWDGWAQGAVKTPLVLGHEFVGEVAALGADVRDIEVGALVSGEGHLVCGKCRNCLAGRRHLCRSTIGLGVGRDGAFAEYVVLPAQNVWVHRTPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGIMAAAVARHAGARNVVITDVSPERLEIARKAGATLAVNVAESSIAEAQTRLGLREGFDVGLEMSGRAEAMRDMIDNMTHGGKIAMLGLPAQEFPVDWAKVVTSMITIKGIYGREMFETWYAMTVLLEGGLDLSPVITGRYSHTDFQAAFDEASTARSGKIILDWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU17</accession>
    <name>A0A0F4IU17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein AU-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001065">
        <property type="protein sequence ID" value="KJY25497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951188.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25497">
        <property type="protein sequence ID" value="KJY25497"/>
        <property type="gene ID" value="VR44_32325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3266"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17565" checksum="3D75E6621E40E723" modified="2015-06-24" version="1">MSTTWTVTLTKDGRTKISYPAAQVSDDGDRISVRAPWAAEGVRDFGFVRFEPGDVFVEHFWRTRWYAVKEVRTGEGVLKGWYCDVTRPAVVREGGILVDDLDLDLWVSADGKTVLRLDEDEFAESGLATSDPEAAARAVRALDALEEQARSAGGLTALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU60</accession>
    <name>A0A0F4IU60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001111">
        <property type="protein sequence ID" value="KJY25184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25184">
        <property type="protein sequence ID" value="KJY25184"/>
        <property type="gene ID" value="VR44_33185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3511"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="13020" checksum="9FC10113801DDFB7" modified="2015-06-24" version="1">MVPGLSGRTLAGIARLERRPSWPGPLFEAWRRWRALAYKPGPWVMYAEDDCCACCDPFAGADVREVLEAACLALPRRAARELRAVLAPLDARFLARTLPDPFTPPGDPWWTGRLDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU85</accession>
    <name>A0A0F4IU85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001130">
        <property type="protein sequence ID" value="KJY25038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951432.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25038">
        <property type="protein sequence ID" value="KJY25038"/>
        <property type="gene ID" value="VR44_33640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3636"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="54"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="31966" checksum="1B5014C2E07FA912" modified="2015-06-24" version="1" fragment="single">PPRIVPRRRVGRRLSAAAALLVLALVVRSVLRNDAFQWDVVGRYFTTSAVLNGLLLTLWLTAVVMVLGFLAGTVLAVMRLSDSPVLRTLSLGYVWIFRSTPLLVQLLFWFNIGALYPTLGLGIPYGPQLFSIKTVNLLGPTLTAVIGLTLHESAYAAEVVRGGILSVDPGQTEAAQALGLSRLRTLRRIVVPQAMRSIVPTAGNMLIGTLKGTSIVSVLAVHDLLYSVQLVYNQNYQVIPLLLVATLWYVAVTTVLSAGQYYVEQHYARGTSRGTAGPKRFHFTKRRYMYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUD7</accession>
    <name>A0A0F4IUD7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">VR44_32980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001100">
        <property type="protein sequence ID" value="KJY25259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951307.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001100.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3201"/>
    <dbReference type="EnsemblBacteria" id="KJY25259">
        <property type="protein sequence ID" value="KJY25259"/>
        <property type="gene ID" value="VR44_32980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3416"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="265"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="416"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="508" mass="55178" checksum="1F3E02649160E92D" modified="2015-06-24" version="1">MTSSTGPFIAAIDQGTTSSRCIVFDRDGRIVAVDQKEHEQIFPKPGWVEHDATEIWTNVQEVVAGAIAKAEITAADVKAVGITNQRETTVLWDKNTGEPVHNALVWQDTRTDALCKELGRNVGQDRFRRETGLPLASYFAGPKVRWLLDNVEGLRERAEAGDILFGTMDSWVIWNLTGGAQGGAHVTDVTNASRTMLMNLHTLAWDEKIAESMGVPLNVLPEIKSSAEVYGHVKDGVLAGVPVASALGDQQAALFGQTCFAEGEAKSTYGTGTFMLMNTGDKIINSYSGLLTTVGYQIGDQKPVYALEGSIAVTGSLVQWMRDQMGLIKSAAEIETLASSVEDNGGAYFVPAFSGLFAPYWRSDARGVIAGLTRYVTKAHIARAVLEATAWQTREITDAMTKDSGVELAALKVDGGMTSNNLLMQTLSDFLDAPVVRPMVAETTCLGAAYAAGLAVGFWPDTDALRANWRRAAEWTPRMPADQRDREYKNWLKAVERSMGWIDDENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX8</accession>
    <name>A0A0F4IUX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001096">
        <property type="protein sequence ID" value="KJY25293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25293">
        <property type="protein sequence ID" value="KJY25293"/>
        <property type="gene ID" value="VR44_32880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3395"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="25916" checksum="8F6C0DCBBFB47827" modified="2015-06-24" version="1" fragment="single">GDLHRPAPVPAAEAAGRPPRRLRIALSFGTAFTATTGKSCDPVVRSAVERLAGRLEELGHEVVPEDPRYGPIGLTFAPRATAGVRELAARAPDPGLLDPRTHGAARTGRLLGGAALRVSRRAEGVLRRRVGELFGRFDVVLTPTTATGPLRIGALAGLGALATDRAMIAACPYAWTWNVLGWPGISVPAGFTPQGLPLGAQLLGPAHSEPRLLSLAAQLEAAEGWATHWPPGTSDRNGPIRPEFDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVL6</accession>
    <name>A0A0F4IVL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001175">
        <property type="protein sequence ID" value="KJY24736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951577.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001175.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24736">
        <property type="protein sequence ID" value="KJY24736"/>
        <property type="gene ID" value="VR44_34445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3869"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="31988" checksum="FC6902A262A89CE7" modified="2015-06-24" version="1">MRIAVTGASGFCGGHVARAAAAAGHSVVCLGRRPGPLGEHRYWDAASAEPALPGVELIVHCAAAVGDPAPGSRAEAEMRAVNVGGTARLLRAAAGRPVVWVSSASVYDPRLDRSRVTEDHPRSHHLNAYGRTKAEGEALALAAGAVVLRPRAVYGPGDTQLLPRLLSRVRAGTLFLPGPDVRLSLTAVENLASACLAAPAWAPGAYNIADAAPYARDAAITAVLHAHGIPARVRHLPLPLAAAAARAAEAASRLTRTEPPLSRYALDQLSHPVTLDLTRSRSQGWTPARALEDYLADVPAAPLSPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVR2</accession>
    <name>A0A0F4IVR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951084.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene93"/>
    <dbReference type="EnsemblBacteria" id="KJY25724">
        <property type="protein sequence ID" value="KJY25724"/>
        <property type="gene ID" value="VR44_31760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3063"/>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="29695" checksum="DD69D8F6C146FC22" modified="2015-06-24" version="1">MSDVLELVDVSVVREGRALVDQVSWSVKEGERWVILGPNGAGPNGAGKTTLLNLASSYLFPTKGSATILGSTLGKPGSDVFELRPRIGVAGIALADKLPKRQTVLQTVLTAAYGMTATWQEEYEEVDEQRARAFLDRLGMSDYLDRKFGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPMAPSMVMVTHHVEEIAPGFTHVLMIRQGKVVTAGPIELELTSRNLSLCFGLPLIVERNDHDRWTAQGLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXX7</accession>
    <name>A0A0F4IXX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000890">
        <property type="protein sequence ID" value="KJY26900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950570.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000890.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26900">
        <property type="protein sequence ID" value="KJY26900"/>
        <property type="gene ID" value="VR44_28940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2129"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="44860" checksum="D95E025C81AD5669" modified="2015-06-24" version="1">MSTDVRAAPAKRRLGAPYDLLLFAFVVSGLGNWIYRLALPLMVFELTGSALNTAVVYALEYAPLLLLSLPGGVIADRFERRRILVVGDLAATVLAGILALVVTSGSSSVLLVYLAAFLLACVEPLYYPAFQGMVPDLVRDKDLERANAWMQMGDNVMSLAGPAVAGVLIAAVGYQGAIWADAGTFAVSALAMVAIRTRSKPPAAQQEGTEPVRRDLLREVKDSLVHITRDNRPLLSGAVLFALANLGTWLVQANLVYYLSDYQSMSPALIGVVFAAQGAGAVLGAAVCPWLGRRFAPGRVVIAGTVLAGAGIVLLIPLRDVVSISVLWALIYGIGTVNMVSWFVLRQRTVPPQMLGRVVATTRMIAFMSIPVASVLGGVLEQRWHNMYLIIALAGGLRLLVGLGALLSPLNSSAGWRNPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYE1</accession>
    <name>A0A0F4IYE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000878">
        <property type="protein sequence ID" value="KJY27017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950503.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000878.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27017">
        <property type="protein sequence ID" value="KJY27017"/>
        <property type="gene ID" value="VR44_28595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2048"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="39030" checksum="B7C0C51D0A34D603" modified="2015-06-24" version="1">MKKFDKDRLLLAAAGPVLALVSALVLTMIVLAASGVDPIDPLRIMIEQAGYEDIQVLIVNQAGIYFLAALAVAIGFRMNLFNIGVDGQYRLAAMVSAVVGAAVSLPAPLHILLIVLIAMATGAFWAGIAGILKARRGVSEVVSTIMLNAIATSLIAWLILPKNLGVQPAGSNDLTTGDIPESGWFPAVSLSGGDIYGFTFIAFALGVVYWFVLNRTRFGFDLRASGASESAAQASGVEPKKMIMTAMLISGAVAGLTGMPLLLGESHTYNLSFPLGVGFTGITVALLGRNNPIGIFFSAFLIAFIDKASAGLDTEGYAKEIGTIMQGLIVIAVVVSYELVRRYGIRRQQQKVGEELAAGHALKTDNKEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYJ7</accession>
    <name>A0A0F4IYJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000873">
        <property type="protein sequence ID" value="KJY27077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27077">
        <property type="protein sequence ID" value="KJY27077"/>
        <property type="gene ID" value="VR44_28465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11804" checksum="B19CB4DF05ED2A27" modified="2015-06-24" version="1" fragment="single">MDLFTRSWTALRRAVADLPDQDFERPCGCAGWLVRDLVCHLVIDAQDVLITLATPAGTEPTVDAVTYWELVEPPTGEDPLDALVPRLAAAYGEPRWLKFHLDDVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYQ3</accession>
    <name>A0A0F4IYQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000865">
        <property type="protein sequence ID" value="KJY27155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950455.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000865.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27155">
        <property type="protein sequence ID" value="KJY27155"/>
        <property type="gene ID" value="VR44_28335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12859" checksum="E21DAD9297C5A328" modified="2015-06-24" version="1" fragment="single">MTRRLRPVGLDFLERAPARLVFTARATARPEDLYRALAEEVTGWPAWFGAVSLARPTGGGAGREIRLRGGVRFQETIVAAEAPRRYAYRVDETNAPGLSALLEEWLLAPAAGPRSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ67</accession>
    <name>A0A0F4IZ67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000885">
        <property type="protein sequence ID" value="KJY26929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950553.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000885.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26929">
        <property type="protein sequence ID" value="KJY26929"/>
        <property type="gene ID" value="VR44_28860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2112"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="214"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="44718" checksum="33FA3890A684F13E" modified="2015-06-24" version="1">MRSTSAVGREEWDALVPPDRVYLSHDWLRAVEECFGFELVLFLLRDGGRTVAGVQGLLVRDPDAFPYHDPTGALFGDYEMDHLRQALERDRSPQESAEAGALLAAVVRAEAGHTRAAAYPALVMTSPYGYASDVLTLPGTAREGAIGELLAAVDAFCRAEGIPSQSFLWESGGDADLHRALAGHGYLEFLSDLEYDLDLGACASLEEYLGTLERKRRTVVRAEIRKFSEAGLRVERIADPDPELIARCAELSEGQQKKYGLPVDRGAMERLFTALLAAPALGPALYVVRREEERGPDVSGFLLCLEAGGVLHPKFLGFDATAVGAGYAYFNLVFYHQVERAVAGGVRRISYGMGSADAKRLRGCRPAPVRGWIRFSSPSAHRRIEPYVTVFDCLKKQLLGNQDGRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J021</accession>
    <name>A0A0F4J021_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000814">
        <property type="protein sequence ID" value="KJY27615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950255.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000814.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27615">
        <property type="protein sequence ID" value="KJY27615"/>
        <property type="gene ID" value="VR44_27205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11306" checksum="700762BF7C360A9D" modified="2015-06-24" version="1" fragment="single">MGTDVRTVEVPLGDGTDGVLRVQIREVDESLARVGRGGGGAVARASRTFGDMVDAVRPVADSFVSRLGGMVHRPDEITLEFGVSLSAEADVVIASTATEANFSVTLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J089</accession>
    <name>A0A0F4J089_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">VR44_27020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000807">
        <property type="protein sequence ID" value="KJY27685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950220.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000807.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5226"/>
    <dbReference type="EnsemblBacteria" id="KJY27685">
        <property type="protein sequence ID" value="KJY27685"/>
        <property type="gene ID" value="VR44_27020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1566"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY27685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26642" checksum="58D1C68083931942" modified="2015-06-24" version="1">MSLAVRVIPCLDVDNGRVVKGVNFQNLRDAGDPVEMAKLYDAEGADELTFLDITASSGNRETTYDVVRRTAEQVFIPLTVGGGVRTAEDVDKLLRAGADKVGVNTAAIARPELIQEIAERFGRQVLVLSVDARRTESGSFEVTTHGGRRGTGIDAVEWAHRAAELGAGEILLNSMDADGTKDGYDTEMIAAVRKHVTVPVIASGGAGKLEHFPPAIAAGADAVLAASVFHFGELRISEVKATLREAGHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0H5</accession>
    <name>A0A0F4J0H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_26750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950170.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000798.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3183"/>
    <dbReference type="EnsemblBacteria" id="KJY27772">
        <property type="protein sequence ID" value="KJY27772"/>
        <property type="gene ID" value="VR44_26750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1508"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="33"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="51070" checksum="3518677A14FEE54A" modified="2015-06-24" version="1">MSDRTLTEAPAEASSRHVDAGDEGYSKDLKSRHINMIAIGGAIGTGLFLGAGGRLAGAGPSLAIAYAVCGVFAFFVVRALGELVLYRPSSGAFVSYAREFMGEKGAYTAGWLYFLNWSTTTVADITAAATYAHFWSMFTDIPQWVLAFIALAVVLTANLISVKYFGEMEFWFSLVKVAALAIFLLVGIYLVATSHDIGGSTPGLANITDHGGIFPSGVLPMLLVIQGVVFAYASVELCGVAAGETENPEKIMPKAINSIMWRVGLFYVGSVVLLALLLPYTEYSSDQSPFVTVFDKLGVPGAAGIMNLVVLTAALSSLNSGLYSTGRILRSMALSGSAPKFTGVMNKGKVPYGGVLFTAAFGVAGVGLNYWMPGEAFELVLNLASIGILGTWAMVMICSLFFWRRAQKGLVERPGYKLPWAPYTQIVTLVFLVTVLVLMWCDGGVGRTTVMILPGIAAALVGGWFLVRRRVNQIASSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1K6</accession>
    <name>A0A0F4J1K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000903">
        <property type="protein sequence ID" value="KJY26796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26796">
        <property type="protein sequence ID" value="KJY26796"/>
        <property type="gene ID" value="VR44_29160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2176"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="25330" checksum="41B3E641FAB03B03" modified="2015-06-24" version="1">MHGMSPERGDNDPREDALTVARLWQTMVTTRALSWGAGNPSWTHYDGDTRPGTPAGAAALADENIAELTGQLRQIEAVEWAQRVRFEGRVMRPTSTDSVAAMLALHSAKDLPAPQQVRELADALQEAGEIPPDHLDSEDLLTAVQCLGPRQNIDVRERILNGKKLTKLLRENLAIYLWEVTHPEWMKMFWETPKLARTTAIGELRLSHLKLEQRKIRGRVLNVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J228</accession>
    <name>A0A0F4J228_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chaplin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_26730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000796">
        <property type="protein sequence ID" value="KJY27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950167.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000796.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27803">
        <property type="protein sequence ID" value="KJY27803"/>
        <property type="gene ID" value="VR44_26730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1505"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470054" description="Chaplin domain-containing protein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="24116" checksum="BBB7FCBF69C00266" modified="2015-06-24" version="1">MRRPVQVTRKTLITMAAAGGVLALGGGYAQADAGASGHTANSPGVLSGNNVQAPVDVPVNACGNTVTVVGGLNPAFGNRCANESHGPQHPGHPGNPGTPGHPGNPGDGDEDCDDEPEHPGHPGGEHPGQPGNPGTPGGHTPGGHPGTPGGHPGTPGGQTPGTPGTGTPGGGQQNPGTPGGQTPGTGTPGTGTPGTGTPGTTTGPGTGGSTTPAAHSAPAPDAALAATGAGAAMTAGLPLAGGLLLAGTVLYRRARNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2V5</accession>
    <name>A0A0F4J2V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000754">
        <property type="protein sequence ID" value="KJY28184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950010.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000754.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28184">
        <property type="protein sequence ID" value="KJY28184"/>
        <property type="gene ID" value="VR44_25915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1247"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15183" checksum="A88F1C5605849379" modified="2015-06-24" version="1">MAHTPTTPRGHSDTALAAAGGLVVFAAVMLLITGVLAICRGIMGIVEDEVFVHTPRYVFQFDLTTWGWLHLIFGIIAVIVGTALFKAPLWGRIAGIAIASVVILVNFLSLPYYPFWAIISIALSGFIIWALCIISPEDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3E6</accession>
    <name>A0A0F4J3E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000695">
        <property type="protein sequence ID" value="KJY28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949703.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000695.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28897">
        <property type="protein sequence ID" value="KJY28897"/>
        <property type="gene ID" value="VR44_24250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.830"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="35879" checksum="4F25976E8681C6DB" modified="2015-06-24" version="1">MERRSIGSGPLTVGAIGLGCMPMSWAYAPSRRRGEESLRTLHTALDLGANLLDTADLYGPFTNELAVGRVLRERRAEAFVSAKVGLRAGEGHVVADGRPEYVRRACDASLRRLRTDVIDLYQLHRVDPEVPVEETWGAMAELVQAGKVRALGFCALGAGAGPGAGRRGDREYRSTLRYLERAQQVFPVTAVQAELSVWSPEAAWQLLPWCAARGVGMLAAMPLGSGFLTGTLTPGQGFEEADVRARHPRFTAHAMASNQVLVAELRRVARRHGPEVTAAQVALAWVLAQGPHVVPVPGAGRARWAAENARAAEVRLTAGELAGFAALPATVGAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3L8</accession>
    <name>A0A0F4J3L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000696">
        <property type="protein sequence ID" value="KJY28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949709.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28880">
        <property type="protein sequence ID" value="KJY28880"/>
        <property type="gene ID" value="VR44_24280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.836"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11788" checksum="5803445A14E4E5A1" modified="2015-06-24" version="1">MTSDRTEPFAWTDGIEARWRGPASEAYRAKHRAAAEDAVRIRRAMQLLAKAIRLSKDGFSAQELEILEDFRRLQSRADIQAEADALSTPDTTPGPPPGPRSRIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4A9</accession>
    <name>A0A0F4J4A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_23530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000665">
        <property type="protein sequence ID" value="KJY29187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949571.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000665.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5210"/>
    <dbReference type="EnsemblBacteria" id="KJY29187">
        <property type="protein sequence ID" value="KJY29187"/>
        <property type="gene ID" value="VR44_23530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.648"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="10">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130811" checksum="1E71BCB1D3CB8ABB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4I1</accession>
    <name>A0A0F4J4I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000792">
        <property type="protein sequence ID" value="KJY27846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950148.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000792.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1160"/>
    <dbReference type="EnsemblBacteria" id="KJY27846">
        <property type="protein sequence ID" value="KJY27846"/>
        <property type="gene ID" value="VR44_26635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1452"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26100" checksum="05E3F0171864B09D" modified="2015-06-24" version="1">MNGSGNGPLQGAVVAVAGAGGPAGRAALLRLAEAGATVVASDADAARLAESVDAARYAHGGATVTGDTVDLLDLEATKAWAERTEKEFGRVDGLVHLVGGWRGSKTFTDVDLADWDLLEKLLIRTVQHTSLAFHDALVRSGRGRYVLISQSGAHKPVANNAAYNAGKAAAEAWTLAMADSFRKAGGEDGPAAAAAILVIKALVHDAMRAERPNAKFAGFTDVKELAEAITGVWERPASDVNGQRLWLTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4R9</accession>
    <name>A0A0F4J4R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000650">
        <property type="protein sequence ID" value="KJY29362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949491.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000650.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7539"/>
    <dbReference type="EnsemblBacteria" id="KJY29362">
        <property type="protein sequence ID" value="KJY29362"/>
        <property type="gene ID" value="VR44_23105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.560"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="841" mass="90194" checksum="AED56887C92BBC63" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4X0</accession>
    <name>A0A0F4J4X0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalt transport protein CbiN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Energy-coupling factor transporter probable substrate-capture protein CbiN</fullName>
            <shortName evidence="10">ECF transporter S component CbiN</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cbiN</name>
        <name evidence="12" type="ORF">VR44_24505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CbiN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949751.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28798">
        <property type="protein sequence ID" value="KJY28798"/>
        <property type="gene ID" value="VR44_24505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.896"/>
    <dbReference type="eggNOG" id="COG1930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00330">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003705">
        <property type="entry name" value="CbiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38662">
        <property type="entry name" value="PTHR38662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02553">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01165">
        <property type="entry name" value="cbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 10" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY28798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12622" checksum="6B29A59284A3B081" modified="2015-06-24" version="1">MTRNAKINTLLLLLVAALAVLPLALGLGEGKEEPFTGADAQAESAITELKPDYKPWFSPLYEPPSGEVESALFALQAALGAGVLAYYFGVRRGRRQGAAQARAQGAAREQDAAEPVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4X5</accession>
    <name>A0A0F4J4X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">VR44_24535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042811644.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000701.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3013"/>
    <dbReference type="EnsemblBacteria" id="KJY28803">
        <property type="protein sequence ID" value="KJY28803"/>
        <property type="gene ID" value="VR44_24535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.902"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="44682" checksum="A229BD6D4859E4C9" modified="2015-06-24" version="1">MSVLNTPLHELDPDVAAAVDAELVRQQSTLEMIASENFAPVAVMEAQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAAAMFALLKPGDTIMGLNLAHGGHLTHGMKINFSGKLYNVVPYHVDESGQVDMAEVERLAKESKPQLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHVVTTTTHKTLGGPRGGVILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEFKERQERTLEGAKIIAERLVQPDVTEVGVSVLSGGTDVHLVLVDLRNSELDGQQAEDRLHEIGITVNRNAIPNDPRPPMVTSGLRIGTPALATRGFGAEDFREVAEIIAQALKPAFDADDLKARVSALAAKFPLYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J576</accession>
    <name>A0A0F4J576_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000687">
        <property type="protein sequence ID" value="KJY28974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949661.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000687.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28974">
        <property type="protein sequence ID" value="KJY28974"/>
        <property type="gene ID" value="VR44_24035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470739" evidence="2">
        <location>
            <begin position="30"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="360"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="547" mass="57905" checksum="CF1206EAD121ECB9" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5L2</accession>
    <name>A0A0F4J5L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">VR44_23885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949636.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000681.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29053">
        <property type="protein sequence ID" value="KJY29053"/>
        <property type="gene ID" value="VR44_23885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.750"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="214"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY29053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="40300" checksum="CAE9EA84E2D2F9A3" modified="2015-06-24" version="1">MNLSSALPRSFRLLVTGGGTGGHTYPALTAIRTLQGRLAAAGGTLDVLWIGTADGLEARVAPAEGIAFKTVATGKIRRSANPLKMLSAANMKDMARVPLGVAQARAIVSEFEPDVVLATGGYVAVPAGLAARLCKRPLVLHEQTVRLGLANRKLAGSATRIAVSSESSLPLLPAEVRDRAVVTGNPVRPEVLSGHPDKAVHALNLVGFDRRLPTVYVTGGAQGAQQINGVVREVLPWLLSHANVIHQCGPANVDELRFAAAGLDPVLAGRYHVTGFVGPELPDVLALADIVISRSGAGTLAELTALGKPAVFVPLATSAGNEQAHNAQYLADAGAAVALLGEVTAHGLAEAVGPLLTDAGRRAQMAERARAYGRPDAAERLVDVLLAAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Z5</accession>
    <name>A0A0F4J5Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000665">
        <property type="protein sequence ID" value="KJY29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5212"/>
    <dbReference type="EnsemblBacteria" id="KJY29188">
        <property type="protein sequence ID" value="KJY29188"/>
        <property type="gene ID" value="VR44_23535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="24585" checksum="508EE7108AD024C2" modified="2015-06-24" version="1" fragment="single">MERVDRCVVLVDAGYLLGAAASLLAGEPSRSRITVDHSALIQGLRERAEADTQQPLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNRACSDVVLVTGDGDLLPGLMSAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRAWITGAVRARDLAGLCPPPPAPRPEIAAILSAPLPEAALAEAARNGTPPAPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Y0</accession>
    <name>A0A0F4J7Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948980.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6988"/>
    <dbReference type="EnsemblBacteria" id="KJY30482">
        <property type="protein sequence ID" value="KJY30482"/>
        <property type="gene ID" value="VR44_20350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8779"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="18101" checksum="3F4E551A8A971303" modified="2015-06-24" version="1">MDTTRTGGQGAQRRGRRVMMTDGEVDAFLREQRTCRVATVSPDGRPHVGALWFAWDGTSLWLYSITRSRRWSDLRKDPRISVVVDAGEEYGELRGVELSGTAVFVGEAPRTGEPCPELEEAERIFPRKNFGIEEMPHDGRHAWIRLTPDAIVSWDFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8B8</accession>
    <name>A0A0F4J8B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30642">
        <property type="protein sequence ID" value="KJY30642"/>
        <property type="gene ID" value="VR44_19965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8614"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="34615" checksum="4D17C09F1DBE791B" modified="2015-06-24" version="1">MSAERCPECGAAGADCTCARGVGFNPLRIRPYMAVPEADGTVPAQTPTPPQPVLGAVAPPGPTAGSPFPALPPDPAPGVPGGDEATTTAIPPLPSTPAVIPPVPAAEAPTAVFPPVAAAPQATGAAIPGPPPAADQTMPLRAVPPRGPGARRPRAGAGRPEAKRRRAVPLLAAAGAVVAAGVLALAVGLFTGSGEDGTALAEPKPSVSVAGETPAAPSETPSGPAESASAPASPSASASASRSASPSPSASRSSAPPSPSPSASTPRATKPVAPPPPPAAKPATLRSGDSGPEVLKLQRLLAERGMYDGRFDGRYGRSVERAVTDFQMEYGVYEDDWGVYGPATRRALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8G8</accession>
    <name>A0A0F4J8G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949552.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5191"/>
    <dbReference type="EnsemblBacteria" id="KJY29251">
        <property type="protein sequence ID" value="KJY29251"/>
        <property type="gene ID" value="VR44_23440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.630"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10927" checksum="61A8B3EC9D330FFC" modified="2015-06-24" version="1">MGIALDVVYIALSCFLIVLIFRLVMDYVFQFARSWAPGKAMVVVLEATYTVTDPPLKLLRRFIPPLRLGGVALDLSFFVLMIIVYILISFVRAAASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9I9</accession>
    <name>A0A0F4J9I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948996.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6641"/>
    <dbReference type="EnsemblBacteria" id="KJY30459">
        <property type="protein sequence ID" value="KJY30459"/>
        <property type="gene ID" value="VR44_20420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8794"/>
    <dbReference type="eggNOG" id="ENOG50316DR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="21693" checksum="0B9D43ACA2F13064" modified="2015-06-24" version="1">MPLHVPPAPAPALRSVLAALGSPTAVHEAHTPALRAVQGPMTAELPLPVHVLDRLSVSGRAADGRPPRTRLTGWRFLIRSGDRFVAAADTRLTPDGWAFSHFFEGPYVAATERALRQAEQLGKSYQPRLLSVPELYMLTLWLHGAVGADAAAGLPAAADLLVPLAPAPPGIAPYRPHPVSELLPVLTHRLTPAAPPLPPTLAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9K2</accession>
    <name>A0A0F4J9K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_22425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949365.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29656">
        <property type="protein sequence ID" value="KJY29656"/>
        <property type="gene ID" value="VR44_22425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.374"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470249" evidence="4">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28855" checksum="72A41A1F89EA6813" modified="2015-06-24" version="1">MKVPKAGAVAAVIALAATASGCGGEAKKEPISVGIKFDQPGIGMREADGTFTGFDVDVATYVAKELGYKANEIEFKQVYSSDRELLIQYNEVKFVAASYTINDKRREKVDFAGPYFVAHQDLLVRADDNSITKAEDLNTKRLCSVTGSTSAENVRSKLAPKASVLELGGYSECLVALQDNLVDAMTTDNSILAGYAARKGNEGKFKLVGLNLSNENYGIGIKKGDSALQKKINAALSKMVSDGSWEAAVKKNFGQANYKYEPAPRVTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA78</accession>
    <name>A0A0F4JA78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30709">
        <property type="protein sequence ID" value="KJY30709"/>
        <property type="gene ID" value="VR44_19765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="12176" checksum="D80CC6640A8B2537" modified="2015-06-24" version="1" fragment="single">MAGPAFRAAAVRVRVPASSANLGPGFDALGLALGLYDDVVVRVADSGLNIDIAGEGADTLPRDESHLLVRSMRTAFDLLGGQPRGLEVVCANRIPHGRGLGSSSAAICAGIVAARAVTIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAA8</accession>
    <name>A0A0F4JAA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">VR44_19845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948888.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3109"/>
    <dbReference type="EnsemblBacteria" id="KJY30683">
        <property type="protein sequence ID" value="KJY30683"/>
        <property type="gene ID" value="VR44_19845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8588"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="153"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="383"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="531" mass="57174" checksum="6E7C6A3715C124D0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAB1</accession>
    <name>A0A0F4JAB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000542">
        <property type="protein sequence ID" value="KJY30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30739">
        <property type="protein sequence ID" value="KJY30739"/>
        <property type="gene ID" value="VR44_19620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="12713" checksum="D12B963945F2A366" modified="2015-06-24" version="1">MTVLSAEDVKPEDIGILSLHYVEGVAQLVVSGGTVLPDHLQVVTPEGATVATFIPVPTEAARNLIVQDDGSNVLYTRSGEAIWHTNTASPTGSNDSVATIVNNGQFVIPKGSDLYEADPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAT1</accession>
    <name>A0A0F4JAT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949161.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5725"/>
    <dbReference type="EnsemblBacteria" id="KJY30071">
        <property type="protein sequence ID" value="KJY30071"/>
        <property type="gene ID" value="VR44_21345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8994"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9371" checksum="3BE8A8115E74BC9A" modified="2015-06-24" version="1">MQDTGTVTMYSTTWCGYCRRLKTQLDREGIAYNEINIELDPESAKFVEQANGGNQTVPTVLVKSSAGNESVMTNPSLAQVKQALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAY6</accession>
    <name>A0A0F4JAY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000497">
        <property type="protein sequence ID" value="KJY31375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948594.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000497.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31375">
        <property type="protein sequence ID" value="KJY31375"/>
        <property type="gene ID" value="VR44_18280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8204"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="367" mass="38774" checksum="78EF5E7CB2CE594B" modified="2015-06-24" version="1">MSRPVPWIPAVLYGAVLLGGVYYAVIGPGPGARTAAFAALLSALAALDLCEPRQWRGRRIPAGAVFVLRVLLLCAVAAVDESGLSRVLFVLVPFLAFFAYGSTVAIGLGVGCVAALAGAFTLWVPHWQVRAEYISDLLMFALGVVLALTMAAVAVREQQARTRLEGTLAQVAELSAARERNRLAREIHDSLGHHLTAIGIQLEKAEAFASLDPQGSAQAVSHARWSANRALDEVRASVRTLGPESESEPAGLARALADLVHHLDGGSRRITLDMSGAERRPLLVLYRAAQEGLTNACRHSGATEIRVDVAYDGRGARLQVIDNGSGFDSVDEGFGLTGLRERVRLAGGTMAIDSSAGGTVLTVGVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAZ8</accession>
    <name>A0A0F4JAZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948584.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31390">
        <property type="protein sequence ID" value="KJY31390"/>
        <property type="gene ID" value="VR44_18225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8192"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8519" checksum="855502E11FE1C9B9" modified="2015-06-24" version="1">MATLYVRDLSDEALAELKIRAARSRQSLQAYARTLLEEEAATPSMEDVVTRIRARVSARLSADEVLADLDAGRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBB6</accession>
    <name>A0A0F4JBB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_19030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000522">
        <property type="protein sequence ID" value="KJY31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948740.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000522.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3410"/>
    <dbReference type="EnsemblBacteria" id="KJY31033">
        <property type="protein sequence ID" value="KJY31033"/>
        <property type="gene ID" value="VR44_19030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8410"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="41085" checksum="00A93F7C51CAA378" modified="2015-06-24" version="1">MNNTTVEVPRGLAGVVVTDTQLGDVRGREGFYHYRQYSAVELAASRTFEDVWHLMFRGALPAGPAERDAFAAEIAPLRHLPAEVADALPALARATALSGPLAGLRTALSLLGASAGFRPVYDLDPARRAADALAACAAVPTLLTALHRLGRGLEPVAPRDDLPYAANYLWMLTGEEPDPVKARAVERYLISTVDHGFNASTFTARVIASTGADVAACLTGAIGALSGPLHGGAPSRALDTLDAIGTADRIGPWIRERVLAGDRIMGFGHPVYRTEDPRSRMLRDIARQFGGPLVEFAVEVERQVEEILAELKPGRELHTNVEFYAGVVMELCGLPREMFTPTFCAARVVGWSANVLEQAADSKIIRPAARYTGPTPPQPVPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBH4</accession>
    <name>A0A0F4JBH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31088">
        <property type="protein sequence ID" value="KJY31088"/>
        <property type="gene ID" value="VR44_18910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8322"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="899" mass="97473" checksum="C53DB76187767205" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBY0</accession>
    <name>A0A0F4JBY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000506">
        <property type="protein sequence ID" value="KJY31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948640.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000506.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31253">
        <property type="protein sequence ID" value="KJY31253"/>
        <property type="gene ID" value="VR44_18510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8297"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="436" mass="45981" checksum="B4B04B4E1F43FF08" modified="2015-06-24" version="1">MSASGRSETADDLLAALLDGMDAALCAFDSDGVITHWNREAERILGWTAAEAVGRRGFAGWAVRAADADDVQDRLMSAQDAPGRQVHEFALLTKEGGRILVRTQSAGVPGADGKPAGVYCAFSEVHAQIDLERSIALSEALMEDASWGVVLVDVDLRPAVVNAHAARAFGSGRTTLLGRPLGELLSQGVEELEGALQHVLAEGAPPGPVELWVTVRTPEGERRRCWRCGFLRLASPLAEEPVPLGVGWLFQDVTEARQAELDGGQVRFRSNQLYRAGRAAAECADPAEAAAVRLDFALAGFAEHALVDVLAEDGRRLVRSAVSPSGLALVLPGPGAIPVRYEAAHPALQALDRIGPVRASAPGAPGSEAAEGWARARQWPPGAAHALSTVLRSRGRTLGILTLVRGPSRPAFDRADAAYAEEVASRVASDLALLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCC5</accession>
    <name>A0A0F4JCC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_17010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948355.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31987">
        <property type="protein sequence ID" value="KJY31987"/>
        <property type="gene ID" value="VR44_17010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7931"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="46226" checksum="79EC3955C4A11CA5" modified="2015-06-24" version="1">MSASSAEAAPQPKWWSGLYPGLQKMGRSLQLPIAVLPAAGILNRLGQPDVFGKDGLDWAPVAKVMAGAGGALLDPDLGLPLLFCVGVAIGMAKKADGSTALAAVAGFLVYRGVLHAFPKACPVGTRDIGGGCLTPTDTFAGYTYQNPGVFGGIVMGLLAAWFWQRYHRVKLVDWLGFFNGRRLVPIIMSFVAIAFAVVCLWIWPPVGDALERFSDWLIGLGSLGGGIFGVANRALLVIGLHQFLNVPVWFQFGSFTTPDGVVKHGDINMFLAGDPHAGLFLSGFFPIMMFALPAAALAITHCAKPLRRKEVGGLMLSVALTSFVTGITEPLEYSFLFVAPMLYVVHALLTGVSMAVTWALGVHDGFSFSAGLIDYVINWGLATKPWLIIPIGLGFAVVYYVVFRFAITAFDIPTPGRESDEEIAAMQAENTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD15</accession>
    <name>A0A0F4JD15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000425">
        <property type="protein sequence ID" value="KJY32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948222.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32247">
        <property type="protein sequence ID" value="KJY32247"/>
        <property type="gene ID" value="VR44_16290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7712"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="23417" checksum="C395BD615949DF8D" modified="2015-06-24" version="1">MKLPGSALPASEDRRLRRRLKKVRRTCEGLLAEWGMEHGCGIDELHAYLSAQRGRPIHLIPTAFPERHLFGIWLKTDDFDIIAFEKAASASHKEHIIAHELAHIAFDHQGSLRLDRDEPGTGEPDGTAATDGAGAPEGAGLPFSDVDPEAVRSVLMRSRYSDDEEQEAETMASLILARANKRWTEPAWGVPDEAAEIVARIESGLGRPEQGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD16</accession>
    <name>A0A0F4JD16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000474">
        <property type="protein sequence ID" value="KJY31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31704">
        <property type="protein sequence ID" value="KJY31704"/>
        <property type="gene ID" value="VR44_17660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6278" checksum="D8AFD75134E0F0B0" modified="2015-06-24" version="1">MSVALRSHWQEIKEHSSKDRGDISITTIIIWVAGITGAIAIAGTIAIVVSKYNGKLSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD93</accession>
    <name>A0A0F4JD93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000434">
        <property type="protein sequence ID" value="KJY32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32175">
        <property type="protein sequence ID" value="KJY32175"/>
        <property type="gene ID" value="VR44_16465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7691"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="469" mass="49207" checksum="6FC8522773091224" modified="2015-06-24" version="1">MLDAVVVGAGPNGLTAAVELARRGHSVAVFEAAGSVGGGARTEELTLPGFRHDPCSAVHPLGAGSPVFKTMPLGRYGLEWLHAPLPMAHPFDDGTAAVLSRSVAETAASLGPRDAGAYRRLVEPYLGHWDTLARDFMSLPNTALPRDPLLLARFGLTGLPPSTWLMRRFRDDRARALFSGLVAHVIAPLSGLGTGAVGLVFALAAHAGGWPVPRGGSQSISDALAAYLADLGGAVHTGFEVKRLDDLPPARAYVFDTSPTALARIARLGRAYDGYRYGAAAFKLDYALDGPVPWTAEAPRRAGTVQIGPGSRDIDAALQLASGGRAPRNPFLITAQPSLVDPGRAPEGKHVFWAYGHVPAGWDGDLTEAVERQLERFAPGFRDLVLARATAGPPQLAARNPNYVGGDIACGSAAGLQLLLRPRITLSPYTTAHPAVFLCSSATPPGPGVHGMSGHNAAKAVWRHLRKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE61</accession>
    <name>A0A0F4JE61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000440">
        <property type="protein sequence ID" value="KJY32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948299.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000440.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32089">
        <property type="protein sequence ID" value="KJY32089"/>
        <property type="gene ID" value="VR44_16690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7771"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7385" checksum="BB484660EBA9036A" modified="2015-06-24" version="1">MRISVDRDVCIGAGQCVLAAPEVFTQDDDGLSEVLPGREDGHGSAMVREAARACPVSAITVREEARDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEG7</accession>
    <name>A0A0F4JEG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000497">
        <property type="protein sequence ID" value="KJY31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948595.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000497.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31376">
        <property type="protein sequence ID" value="KJY31376"/>
        <property type="gene ID" value="VR44_18270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8201"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27696" checksum="F5F97FF5AF9C9495" modified="2015-06-24" version="1">MNGPYKPGTPCWIDLMVPDQQAALDFYCDLFGWQGEVGPPETGGYAVCTLKGKPVAGIMKAMNPDGTTPDPMPPTVWTTYLSTDAIDSTLKAVTDAGGTVMMGPMDVMDLGRMAVIADPAGAVVGLWQPGTFDGAGIVNEHGALIWNELTTPDLAAASAFYSSILPVTTARSEMPGAEEYIEFQVAGRAVGGMMDLSKLPPGVPPHWQPYFHVDSVDDIQAAAVRAGATVLAPAFDMAAGRMAVLSDPQGGAFSVITASMQEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEI2</accession>
    <name>A0A0F4JEI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000435">
        <property type="protein sequence ID" value="KJY32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948258.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000435.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32163">
        <property type="protein sequence ID" value="KJY32163"/>
        <property type="gene ID" value="VR44_16485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7695"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19128" checksum="94CCFE4B1AD3BD62" modified="2015-06-24" version="1">MNICVFLSAADLDERYTRPAREFAELLGKGGHTLVWGGSESGLMKVVADGVQESGGRLVGVSVGFLAAKARENADEMVIAGDLAERKALLLAKADAVVIMVGGTGTLDEATEILELKKHGRTTKPVVLLNTAGFYDGLKAQFRRMEEEGFLPVPLTELVFFAEEPVAALAYLEESTGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEZ4</accession>
    <name>A0A0F4JEZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000416">
        <property type="protein sequence ID" value="KJY32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948190.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000416.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32379">
        <property type="protein sequence ID" value="KJY32379"/>
        <property type="gene ID" value="VR44_16135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7653"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9168" checksum="578C6D7810A7FAD0" modified="2015-06-24" version="1">MKASKIAYKPVGLALGAVSGMAAGLAFKQAWKMLGHEDDAPDATDENRTWREVLVAAALQGAIFAVVKAAVDRAGAATTRRLTGTWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGJ1</accession>
    <name>A0A0F4JGJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000386">
        <property type="protein sequence ID" value="KJY32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947996.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000386.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32883">
        <property type="protein sequence ID" value="KJY32883"/>
        <property type="gene ID" value="VR44_15090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470523" evidence="1">
        <location>
            <begin position="27"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="38984" checksum="870CC557E180183F" modified="2015-06-24" version="1" fragment="single">MNKAAWRSLGLATVLAVLPLAATATAEAEAPEPLSAEVVAAMTPQQQGEVLEPLRAVADAAARVGRGAYADLYTQVEMAPDYRSVNVYLTDTARGAAFLDAVRKAGPEADTKLLHVRKSAKSLQQIRKEINTFRSRRDLPFKIHMAGSTVDGGAIELSVDDAKAARRYLAEPAVTQELAAARTTPIRVRQSPPAVPLSRWNDSAPFYAGAALGPANGSFAHCTSGIPAHSTVDNRQWLVTAGHCYGLGESVFTAGGNRVGTVGAKLDDLDSAFIETATSRYTWDGLDAQGYTRRLNGVRNAAVGDFTCHLGYTTKVACNIRTAYAGNATWVNNGAYVWGSASDPNTYPVIARTGDSGGPVITINDENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH10</accession>
    <name>A0A0F4JH10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">VR44_14700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947927.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5609"/>
    <dbReference type="EnsemblBacteria" id="KJY33038">
        <property type="protein sequence ID" value="KJY33038"/>
        <property type="gene ID" value="VR44_14700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7267"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8587" checksum="9925C4050E8C4369" modified="2015-06-24" version="1">MSETDTALGYEQARDELVEVVRKLEAGGTSLEESLALWERGEELAKVCRHWLEGARARLDSALAAREAAEAADGEGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI15</accession>
    <name>A0A0F4JI15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_15665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948102.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32601">
        <property type="protein sequence ID" value="KJY32601"/>
        <property type="gene ID" value="VR44_15665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7535"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="262"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="42269" checksum="A4422D224448CD25" modified="2015-06-24" version="1">MDAAFTAEQDEMRRTLREILGKRCGPDEVKTAARTDAGHDPELWQQLSRQLGLPGLAIAEEYGGVGCTPADLALACEETGRVLLPSPLLATAALAAPLIGALGTAAQRAALLPALAAGELTAALAVPGPALATALALTGENTPGDWAGGGRAGGVQARAGADGWRLYGEVAQVLDGHGAGLLLVAAHTGGFARARTLLFLVRGDAPGLVRDRQATLDETRPQGRIQLRDVQAELLGESEGHDTGEAGPLPALAATGLFAATVLAAEAVGAAGQALARTVDHVCRREQFGRPIGSFQAVKHRLADLYVQVQAARSAAYYAAWDPEQGPLALAQALEALRTTSGEAIQLHGGIGFTWEHDAHLYFKRAAADELLFGPVHRLRAHAARRAGLFAAAGPVTSDPSATPQKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIN1</accession>
    <name>A0A0F4JIN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000349">
        <property type="protein sequence ID" value="KJY33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947738.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000349.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33628">
        <property type="protein sequence ID" value="KJY33628"/>
        <property type="gene ID" value="VR44_13625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6987"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="22709" checksum="F59B0FB4DF09D0D5" modified="2015-06-24" version="1">MPRRSAALDRATPEAIAVAALRLIDEEGPAALSFRALADRLEVSHATVQRRCTDLAGLMDLCTEHLAARLPEIPAGTDWAEATEQRFGALYRLLTAHPGLLVLRGGRPWLGRQLLARLVEPALADSVAAGMSRAEAVTVYRRMYLLTLGCAAFVDHRDPTGATAASRAALAALDPAEFPVLGGDPAELLPALTDHEVYYGALRQLIAAARPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK27</accession>
    <name>A0A0F4JK27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">VR44_14135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="JZWV01000364">
        <property type="protein sequence ID" value="KJY33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004948662.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3372"/>
    <dbReference type="EnsemblBacteria" id="KJY33326">
        <property type="protein sequence ID" value="KJY33326"/>
        <property type="gene ID" value="VR44_14135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7173"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9737" checksum="5C5AF094DA03F867" modified="2015-06-24" version="1">MSSSITAPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGLLTSEAIEAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKG8</accession>
    <name>A0A0F4JKG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000259">
        <property type="protein sequence ID" value="KJY34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000259.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34837">
        <property type="protein sequence ID" value="KJY34837"/>
        <property type="gene ID" value="VR44_11200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6250"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="217"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="36405" checksum="7146A170418D979D" modified="2015-06-24" version="1">MLPEVTFRSSELLPADRFECWRSLMSETHAPMDMQSEHADDFWVNQRTISLGEATVYPLECHPLTFRRTPKLIGKSDPEAYHLSFVKRGTGVVTLGKETIVHTVFDYHTSDTSRPFDLCTGREKFEVIGIEVPKALVPLPPRIAGQVIGKRISAQHGMGALLATFLTQITTDSHSYQPADGPRLSTVLTDLVASLFAGVLDANRSLTPETHRQTLTLRIKAFIQKNSDDPRLDVAAIAAAHHISVSYLHRLFQREGDGATVAGFLHRQRLEGARRDLSDPLRPEVPVHVVAAQRGFSHASAFSRAFRDAYGMPPGAYRRQFLGLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKN4</accession>
    <name>A0A0F4JKN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_11365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000264">
        <property type="protein sequence ID" value="KJY34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34750">
        <property type="protein sequence ID" value="KJY34750"/>
        <property type="gene ID" value="VR44_11365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8001" checksum="9CD6E00D36E7E471" modified="2015-06-24" version="1" fragment="single">MPSPRRGTVLAVLAAAQFTVMLATSIVNVALPQIRDGVGLSDSAITWVVNAYGLAFGALLPAGGRAADLLGRRRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLU4</accession>
    <name>A0A0F4JLU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltraansferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35165">
        <property type="protein sequence ID" value="KJY35165"/>
        <property type="gene ID" value="VR44_10745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5898"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18566" checksum="FD0395069D126436" modified="2015-06-24" version="1">MRIRGVSTADWDAVAALEAAEYGPRGLSEGRTALESRGGASPSTCFTLHHEHRLAGYLLAFPYPPDRCPDLLRPQRTVHRSDNLHLHDIVVAEDLRGRGYGRTLLHHLSATARAAGYRWISLVAVSGMDTFWAAHGYRPRTGVTPPPHYGGDAVYMSKPIRKGHPHGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM67</accession>
    <name>A0A0F4JM67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947566.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000318.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34031">
        <property type="protein sequence ID" value="KJY34031"/>
        <property type="gene ID" value="VR44_12710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6622"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470863" evidence="1">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22168" checksum="3855E45DB6AD93C8" modified="2015-06-24" version="1">MHRRTALSVSAALLAAAPLLAACSGGTRPGTAAVVGGERITTSALQAQVNDVRTAQNRSEQGARLIGATAGLERLKLNKMIQTAVLERAADDAGLSVSTKEIEDVRKAQLQQVGGEKALAAAALEQAQLAPDQIDADTRFKLLRDKLFAHYGSQDKALVKLGEAAKELHIEVNPRYGRWDEKQILLGDQQTPWITQKTMPEQAAPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMM0</accession>
    <name>A0A0F4JMM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_09775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947022.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35612">
        <property type="protein sequence ID" value="KJY35612"/>
        <property type="gene ID" value="VR44_09775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5455"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY35612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="23180" checksum="8E196F8A89C22063" modified="2015-06-24" version="1">MHVLTDNFELYVQGFLGTVQLTVYASLLALVLGFLMASFRVAPVGSFRVFGTVWVNVLRNTPLTLLFFAVLLGLPRFGVVLPFQLFAVLTLGCYTSAFICEALRSGINTVPKGQGEAARSLGMTFGQTLGTVVLPQAFRSVIPPIGSTLIALAKNSAIAGAFSVTELLGTYKPLNEMGYNIIWTFVWIAVGYLIITLSISALFNVLEKRYGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN20</accession>
    <name>A0A0F4JN20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7047"/>
    <dbReference type="EnsemblBacteria" id="KJY35585">
        <property type="protein sequence ID" value="KJY35585"/>
        <property type="gene ID" value="VR44_09895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5527"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="773" mass="80263" checksum="72C1BC105C51935C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN30</accession>
    <name>A0A0F4JN30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947195.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35158">
        <property type="protein sequence ID" value="KJY35158"/>
        <property type="gene ID" value="VR44_10740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5897"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="39571" checksum="98FA253628DE1126" modified="2015-06-24" version="1">MRSEQPRTRATSDPIPFHRAQLGIAVVFALLGFQYATWASRVPALTERLGLSEARLGLLLMACGASAAASFPLVTALMRRLGSRRLVLLSAAVLALLLPALALAPNYPAALAVICCDGVAVGCLNVAMNAQGAALEVAHGRTAMARLHAAFSAGSLGAALLASGVTALTPDLPSHFALACVLLLLLLAWAGPRLLPDASHHGGEEPRRSRAVVTAAALWMGAAMAFATVTEGAMNDWSALYLDTVAGASEQIAPLGIAVVSVTMVTARLFADGLRSRWGDGRVVRAGSALAGTGLALALPAGGIVPTLIGFACVGLGAAAVTPCVYVAAAHKGPDALALVAAMGTTGLLAGPALIGFIASAGGLVWGMGAVAGSALLVTLCATRVTWPRPTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN57</accession>
    <name>A0A0F4JN57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947157.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35264">
        <property type="protein sequence ID" value="KJY35264"/>
        <property type="gene ID" value="VR44_10525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5848"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="56" mass="6577" checksum="050EA636488A1D7F" modified="2015-06-24" version="1" fragment="single">MARRQNPRKPLKDRPNPLDAAGITRIDYKDTDLLRKFVSDRGKIRSRRVTRVTAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN89</accession>
    <name>A0A0F4JN89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">VR44_09570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946980.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35655">
        <property type="protein sequence ID" value="KJY35655"/>
        <property type="gene ID" value="VR44_09570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5315"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="32830" checksum="30F68887E0D2B58D" modified="2015-06-24" version="1">MSASSGIPVVYTEEVREALHEGKAVVALESNVITHGLPYPDNAATARKVEDAVRAGGAVPATICIEAGEIRVGMSDADIERFASLPNIPKVSSRDLPVILAQGGLGATTVASSVVAAELAGIPFFSSAGIGGVHRGAQETWDVSSDLIQFTRSKVAVVCAGAKMILDLGLTLEYLETQCVPVVAYRSDDFPAFYCRTSGHKAPHRLDDEQVIARAIEAHWALGNHSSFLITTPVREEDAIDSTEVDTAIRAAVAEATRDGVSGQAITKYLMRAVDAATDGRSAKANMAVLASCAEAAGRLAVAHAAHLAERAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNY1</accession>
    <name>A0A0F4JNY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946832.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36072">
        <property type="protein sequence ID" value="KJY36072"/>
        <property type="gene ID" value="VR44_08735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4990"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35755" checksum="36EBE0D5E3054B1C" modified="2015-06-24" version="1">MATDRIDADTAAVLVGDAVTAPSMHNAQPWRFVFRRATGVIELHGDPERAMKRTDPDHRALHLGCGAVLFNLRVSAAWHGIGAEVGLLPDSSDAWLLATAALGTPTAEDQGLAVLYDALRHRHTSRRPFSDEAVPPPVLDGLRAAARLEGCRLTIPDRWHTEAVLSLVRDAEHHEEMDPLARAETDAWTAHPQGVAPAPRDDGIPAEAFGPRSAGPTPVRDFGRAHPVPDRGWAVFEEHPQLALLGTPNDTAAEWLRAGQALERVLLQATADGLATSMTSQPLEWPELRWAVRDPLESMGHVQMVLRLGYGPPGPATPRRPVTEVLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP99</accession>
    <name>A0A0F4JP99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000171">
        <property type="protein sequence ID" value="KJY36197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36197">
        <property type="protein sequence ID" value="KJY36197"/>
        <property type="gene ID" value="VR44_08385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="15340" checksum="11DB7239CC8F5103" modified="2015-06-24" version="1" fragment="single">MGLGAAAYTAWVLEVVLSTGLNPIETYVSELAAQDQPLGGLFRATDFTAGLLVFLGGLLALVRLVRLGRHPGPRDPASRRPWAVAGWGGVALFGAATAADAWLPLSCRPTADPQCAARETAGLVPATHQAHAVSSSLAMTGALVGIVALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPH1</accession>
    <name>A0A0F4JPH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000180">
        <property type="protein sequence ID" value="KJY36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36075">
        <property type="protein sequence ID" value="KJY36075"/>
        <property type="gene ID" value="VR44_08645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9150" checksum="3F7D5D49D460BE09" modified="2015-06-24" version="1" fragment="single">MASTPYTVADVMTTNVIAITPETGFKDIAAAMGRWKVTALPVIEGEGRVVGVVSEADLLPKEEFHEHRPGLIEQMRRLGDTAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ07</accession>
    <name>A0A0F4JQ07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000194">
        <property type="protein sequence ID" value="KJY35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946881.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5140"/>
    <dbReference type="EnsemblBacteria" id="KJY35848">
        <property type="protein sequence ID" value="KJY35848"/>
        <property type="gene ID" value="VR44_09015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5066"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="32517" checksum="A43C6901489E3D4F" modified="2015-06-24" version="1">MGLTIGVDIGGTKIAAGVVDEEGTILETYKVPTPPTADGVTEAICAAVSEVSSNHTIEAVGIGAAGYVDDKRATVLFAPNINWRHEPLKDKVEQRIGLPVVVENDANCAAWGEYRFGAGQGHEDVICITLGTGLGGGIIMGNKLRRGRFGVAAEFGHIRVVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPENATVLLGLGDGTPEGIEGKHISQAARQGDPVAVDSFRELARWAGAGLADLASLFDPSAFIVGGGVSDEGDLVLDPIRKSFKRWLIGGAWRPHAQVLAAQLGGKAGLVGAADLARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ92</accession>
    <name>A0A0F4JQ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35999">
        <property type="protein sequence ID" value="KJY35999"/>
        <property type="gene ID" value="VR44_08810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5008"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28291" checksum="E71D036DAD9A505A" modified="2015-06-24" version="1" fragment="single">PLASGEVAMPGPLPDADPRTEVGQVAGALNRMLGHVEDALGRRQASEERLRHFAADASHELRTPVANVRGHAELALRHRGPVPGDVRHALERIEAESQRMTSLVDDLLLLARLDAGRPLERAEVDLTLLVLDATADARAAGPGHHWRLDLPEEPVVVTGDARGLQQAVGNLLANARTHTPPGTEVTVTLATGPESVTVTVADNGPGIPEDLQPEVFGRFVRADHSRSRATGSTGLGLAIVHAVAVAHGGTATVTSRPGHTGFRLVLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQP9</accession>
    <name>A0A0F4JQP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2244"/>
    <dbReference type="EnsemblBacteria" id="KJY36687">
        <property type="protein sequence ID" value="KJY36687"/>
        <property type="gene ID" value="VR44_07415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3956"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="475" mass="51548" checksum="529C079BE51CC8B5" modified="2015-06-24" version="1">MSLPTPTPSAVRSHRKETYKPGAVIGDWRPEDEGFWQITGRRVAQRNLWISIPALMLGFVVWQVWSVTVVKLNDVGFGFSKSQLFWLTAIPGITGGTFRILYTFIGPIFGERKFTAFSTLVLVAPMLWLGFALQDTGTPYWELALIAAVCGIGGANFASSMANIGFFFPKREKGSANGLNGGLGNLGVSVVQLVAPLVVTAAVLGPPAGGPQHDAKQNTDIWLQNGAFLWVPLLVIMALLAWFLMNDLKVAAAPFSQQKIIFRRKHNWLMTWLYVGTFGSFIGFAAGLPLLIKNNFEAQGYEATTYAWIGPFIGALMRWAGGWLSDRIGGARVTMLSFVGMAAALVVVIFALPAGGDQGSFWAFFIGFLAAFAFSGLGNGSTFRQIPVIFREQHMRQAQGQGPEAQAAALKQSEMEAGAVTGFSSAIAAYGFFFIPAMFAAISVTNALWMFIGFYATCLAVCWWFYARKGAEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRC8</accession>
    <name>A0A0F4JRC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000166">
        <property type="protein sequence ID" value="KJY36318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36318">
        <property type="protein sequence ID" value="KJY36318"/>
        <property type="gene ID" value="VR44_08185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4387"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470974" evidence="2">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15227" checksum="A4641C10DD3F40A1" modified="2015-06-24" version="1">MKRFVAAGLLCAAVVLGSSACSSNDTTPQEEASKAAAELCTNLVQLKSDNAALKALNPATATKDQIQKAVDAVQTDWKNVKESKQTMKSAEREAVQEATDNLKKSYDDLPGDTTGKDALTQLQPQIQAVDTAVKQSADSLRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRN7</accession>
    <name>A0A0F4JRN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947016.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35606">
        <property type="protein sequence ID" value="KJY35606"/>
        <property type="gene ID" value="VR44_09735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5447"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="413" mass="45706" checksum="1422770FA9F36E44" modified="2015-06-24" version="1">MPDVFDPRLYAAGVPHERYRVLRERYPVAWQEEPEVQGWPAGPGFWAVTRHADVVRVLRDHTAYSSWLGATQIRDPDPADLPFLRRTMLNQDPPEHGRLRRLVSRAFTPARVDAFAGRARERARTLLAAARDGAEDGAADLVRTVTDEYALLNLTDLLGVPAADRGLLLEWTVRVIGYQDPEDAPAPLLGPDGKPLNPRSPALLGEMFDYARELAAYKRAHPADDVMTALAQGGLDPAELEMFFFLLTVAGNDTVRSAAPGGLLALARDPDAYRTLADGTAPADRAVEELLRVHPPVLSFRRTAARDTELAGTRIRAGDKVVVFHASANHDERVFTDPHRLDLGRAPNPHVSFGDGPHVCLGAHFARLQLRTLYEEWRTAMPAPELTAEPRRLVSNFINGITRLPLRVSGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSC8</accession>
    <name>A0A0F4JSC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000120">
        <property type="protein sequence ID" value="KJY37070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37070">
        <property type="protein sequence ID" value="KJY37070"/>
        <property type="gene ID" value="VR44_06605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3238"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16585" checksum="2DB78BE95EFC42E8" modified="2015-06-24" version="1">MTIAQDVFQPEQYRALLVTFRPVDYIEHWHDGFGKTQPAVVSEFSPLEQVVNSGPKKRRKDVSPKERVLEQLLGAEDPGEAVPVEKPEARLVTVKHVYLVEALRAAQGMQGICAGWIVHVQTPWVLMPPTVSEYGRVFQHCQALGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSP1</accession>
    <name>A0A0F4JSP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946372.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37195">
        <property type="protein sequence ID" value="KJY37195"/>
        <property type="gene ID" value="VR44_06295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3013"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13266" checksum="81C612F54C7ECD71" modified="2015-06-24" version="1">MTTQAAPPPGGAGPAQAPAQVPAEEFARVQQSPEFAELRRSHRSFAFPLTVAFIAWYLLYVLLSNYAGDFMGTKLFGNVNVALVLGLAQFATTFLIAWLYSRHAAAKLDPKAQAIKDRLEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTW8</accession>
    <name>A0A0F4JTW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37198">
        <property type="protein sequence ID" value="KJY37198"/>
        <property type="gene ID" value="VR44_06310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3016"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23531" checksum="A2C38530CC311503" modified="2015-06-24" version="1">MNAVRLRTRPVPQGTGTAGRMLLAAFAAASAADLVSLLAGWHPGHLIAKPLLMPLLAGYVLTLGAPRLLVAALLFGWGGDLALLSGAEPAFLIGMGSFAAGHVCYLALFGRRRTSPALGGAYAVALVGTVALLWGDLPAGLRIPVAGYSLLLASMAYRSSAFGRTAGAGGALFLLSDTLIATGVAEWPQLPRPDFWIMATYLAAQYLLALGAVRREQAYRSEVIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU84</accession>
    <name>A0A0F4JU84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946654.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000154.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36521">
        <property type="protein sequence ID" value="KJY36521"/>
        <property type="gene ID" value="VR44_07815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4269"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15790" checksum="C4DD710092A8389E" modified="2015-06-24" version="1">MTRNLRARDIMTAGVQCVREEQTLLDASRMMRDLNVGCLPICGDDQRLQGLITDRDIVLKCCAEGRDPAQMKAGELAGTLHWVDADSNAQEAVDTMEVHQIKRLPVIDVAGGHRLIGMITEANLAKNLSDAEIAEFAVRVYAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUA7</accession>
    <name>A0A0F4JUA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_05820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000108.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2550"/>
    <dbReference type="EnsemblBacteria" id="KJY37348">
        <property type="protein sequence ID" value="KJY37348"/>
        <property type="gene ID" value="VR44_05820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1979"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="44271" checksum="9721EAB71C9BA8C1" modified="2015-06-24" version="1">MPSALPDGDPMPEDGSLPSHALAGAGERPLGFYLHVPYCATRCGYCDFNTYTATELRGTGGVLASRENYADTLIDEVRLARKVLGDDPRAVRTVFVGGGTPTLLPAADLVRMLGAIRDEFGLAEDAEVTTEANPESVNPQYLAELRAGGFNRISFGMQSARQHVLKVLDRTHTPGRPEACVAEARAAGFEHVNLDLIYGTPGETDEDWRASLDAALGAGPDHISAYALIVEEGTQLARRIRRGEVPMTDDDVHADRYLIADEVMERAGYSWYEVSNWATSEAGPCLHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAAALAEGRSPGAGRELLSEEDRRVERILLELRLVDGVPLSLLAPAGLAASRRALSDGLLEAAPYEAGRAVLTLRGRLLADAVVRDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUD6</accession>
    <name>A0A0F4JUD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_07700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946632.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36586">
        <property type="protein sequence ID" value="KJY36586"/>
        <property type="gene ID" value="VR44_07700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4152"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="30416" checksum="6182EC095ABEB9E4" modified="2015-06-24" version="1">MTTTSPATGLTAPRPRGGIVGSAKDSLVIARRNLLRMSRIPEVIVFGLVQPVMFVVLFSYVFGGSIAVGGSTSPQAYREFLMAGIFAQTVTFATAGAGAGIADDMHKGLIDRFRSLPMARGAVLTGRTLADLVQTTLTLVVLAVVALLVGWRTHTSLVEVLAGFALLLLLGYAFSWIGALIGLSVRTPEAATSGGLIWLFPLTFISNAFVPSENMPPFLRTIAEWNPFSATVQAARVLFGNLPEGYPVPDAWPMQHPVVASVLWSVLIIVGFRTLAVRKYRSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUN9</accession>
    <name>A0A0F4JUN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter NarK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36696">
        <property type="protein sequence ID" value="KJY36696"/>
        <property type="gene ID" value="VR44_07375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3948"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="47555" checksum="C9C80045D1B6F554" modified="2015-06-24" version="1">MTRWAPEDPSFWQSTGKRVATRNLWIAVPALLVAFVVWQVWSITATNLKDVGFGFSQSQLFWLTAIPGVTGGTARVFYTFLGPMVGQRRFTALSTLVLIVPLLWLGFAVQDPQTSYGTMVAIAALCGIGGANFSSSLANIGFFYPKKEKGNATGINGGLGNLGVSVVQLLTPILITSSVLAIGAGQKKANGSEIYLQNAAFVWVPVVIVLAAVAWFGQNDLKVASTPFSQQKIIFRRKHNWLMTWLYIGTFGSFIGFAAALPLLIKTTFPAYSVATYAWMGPALGALARWAGGWIADKLGGARVTILSFAGMGASIIGVINFLPGGSDSGSFHGFFLCFLAAFFFSGIGNGSTFRQIPVIFRGQHLKGLTEGTPQYAAALKQAEIESGAVTGFTAGIAAYGFFFIPAMFANFAVTSAMWGFVAFYASCVVVAWWFYARPGAEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV51</accession>
    <name>A0A0F4JV51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ORF">VR44_07105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946522.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4622"/>
    <dbReference type="EnsemblBacteria" id="KJY36856">
        <property type="protein sequence ID" value="KJY36856"/>
        <property type="gene ID" value="VR44_07105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3764"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="24580" checksum="7195424A7B8106D2" modified="2015-06-24" version="1">MTTRIGVVTFPGTLDDRDSLRAVRLAGAEPVSLWHRDKDLHQVDAVVLAGGFSYGDYLRAGAISRFSPVMETIIEQAKAGMPVLGICNGFQVLTEAHLLPGAMLRNNHLHFICRDQKLRVENAETAWTGDYTGGQEISVPLKNMDGRYVADERTLDELEAEGRVAFRYLDVNPNGSLRDIAGITNAAGNVVGLMPHPEHAVEPLIGTGRTDGLPFFTSVLKKLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW47</accession>
    <name>A0A0F4JW47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946383.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37206">
        <property type="protein sequence ID" value="KJY37206"/>
        <property type="gene ID" value="VR44_06360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3026"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="25691" checksum="97A14B1839D45D56" modified="2015-06-24" version="1">MDLGLKDRVYIVTGATRGLGFASARELAADGAKVLLTGRDAQRAAAAAAELGPDVVGLAADNADAGAAERLVAEAVARFGRLDGILISVGGPAPGGATDNTDEQWAAAFESVFLGAVRLARAAAAVLGEGGVIGFVLSGSVHEPIPGLTISNGLRPGLAGFAKSLSVELGPRGIRVIGLLPARIDTDRVRELDALSGDEKAVRAGHESRIPLRRYGRPEEFGRTAAFFLSPAASYLTGVMLPIDGGSRHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW82</accession>
    <name>A0A0F4JW82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_04525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946041.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37988">
        <property type="protein sequence ID" value="KJY37988"/>
        <property type="gene ID" value="VR44_04525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.714"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY37988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="526" mass="55136" checksum="BFF9B2C1CDEAA9FB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWK3</accession>
    <name>A0A0F4JWK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">VR44_04260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946000.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene846"/>
    <dbReference type="EnsemblBacteria" id="KJY38118">
        <property type="protein sequence ID" value="KJY38118"/>
        <property type="gene ID" value="VR44_04260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.143"/>
    <dbReference type="eggNOG" id="COG1949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21919" checksum="D3B4291D210089A7" modified="2015-06-24" version="1">MNDRMVWIDCEMTGLSLTDDALIEVAALVTDSELNVLGEGVDIVIRPPDAALENMPDVVREMHTASGLLDELAGGTTLADAEAQVLAYVREHVKEPRKAPLCGNSVGTDRGFLSRDMPALEAHLHYRIVDVSSVKELARRWYPRAYFNSPPKNGNHRALADIKESIAELRYYREAVFVPQPGPDSDTAKAIAAKHVVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXP7</accession>
    <name>A0A0F4JXP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945812.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38609">
        <property type="protein sequence ID" value="KJY38609"/>
        <property type="gene ID" value="VR44_03195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7854"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="36865" checksum="65FD16EF0B147A21" modified="2015-06-24" version="1">MSPHRSAPAPALAVVGATGAVGSILLQILSQRADVWGGIRLIASPRSAGRVLAVRGEETEVLALTEDAFEGLGAGDVVLFLTPAEVSARWAPVATARGAVVVDQSAAFREDPEVPLVVPEVNAAAVRSRPRGIVAGPDCVTAAMIAALGALHAEYGLAELAVSSYQAASRSGRAGAEALRRQLSLVAGTPLGEQPGDVRRAVGEDTGPFAAPLALNVVPWSGELRADGWSSHELAVRAETRRILGLEALPVSVTCVQVPVVTGHSLTVRARFEREVAAAHAREILEAAPGVVLVDDPAAGEWPTPADAAGTDPAWVGRLRGSLDDARALEFFVCADNLRKGAALNAAQISELIAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYB2</accession>
    <name>A0A0F4JYB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946059.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37961">
        <property type="protein sequence ID" value="KJY37961"/>
        <property type="gene ID" value="VR44_04630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1007"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="15671" checksum="664DE0C08B67BF77" modified="2015-06-24" version="1">MNAVELFLLGRTLMKIGEGAMPEPQGGGRHGGSVRSVLIVASDVAAHADSAVGEIATRTGLPQSQVSTAVARLKEAGAVVTAPDPADRRRMLVRQAPEVSGRVAQVRAGSVEDALTTALGEAAPEHLQEVADALEVLARHLPPQAMTRLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYK3</accession>
    <name>A0A0F4JYK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946010.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4231"/>
    <dbReference type="EnsemblBacteria" id="KJY38066">
        <property type="protein sequence ID" value="KJY38066"/>
        <property type="gene ID" value="VR44_04310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.429"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="33753" checksum="6ED16A1604D91EDC" modified="2015-06-24" version="1">MTTVIKAPGESAAERSAGSAGPGGGKPRSDGMVLNVFSHGFLAVWAILIVLPLVWLALGSFKTDSQIGASALSWPAHWHFDAFGRAWDKGIGGYFGHTLIVLAFSVPLTMLLGSMAAYVLARYPFPGNRIIYYFFVSGAMFPVFLALVPLFFMVKRLDMLNTYQGLILVYVAYSMPFTVFFMHSFFRTLPTAVHEAAVIDGASDTRIFFQVMLPMAKPGLISVGIFNVLGQWNQYILPSVLMQPQSGSDPERYMLTQGLIQLQYQMGYETDLPVLFAGVTIAMIPMLVVYLSFQRQIQAGLTSATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYK7</accession>
    <name>A0A0F4JYK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946014.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38071">
        <property type="protein sequence ID" value="KJY38071"/>
        <property type="gene ID" value="VR44_04355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.439"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="39493" checksum="3F15493A2A097B10" modified="2015-06-24" version="1">MATRSRRSPNKSPQRPSGPSPAPARDGNPAALGPLTGRWVLAGKDGRLTAYARTGGGLLRWTEQVPGGPGWNGPDFFPADGLTDLSVGQGPDGYAHFTGRRRAPNGDTETLTYHHAVQYQSGRPIGPWESLGTLYHNVEMSLRGGPPTVTVDAQGAPHIFVRNNGRGIHMKRQDSKGNWGRWEDLRGSMTFEGGCASSTADGLTGFAAPGEKGLTFWAQDAPGGPLKMGEVVPYLARDGSLAALETAPRRVTHFWHAADGSGVYAHREGAGVMALGGGPAYGAVAAVRALVDGYDCTVLAHRGADGRTALAAYPTENEAAGLWWTAIGEECPDSPALAVDAHGLVVIASISARGELLVNRQKDSSGLSLGRWQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZC4</accession>
    <name>A0A0F4JZC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000069">
        <property type="protein sequence ID" value="KJY38371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38371">
        <property type="protein sequence ID" value="KJY38371"/>
        <property type="gene ID" value="VR44_03795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8662"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dak1_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="31332" checksum="DFC3286846B0D132" modified="2015-06-24" version="1" fragment="single">QEEGGPGYEVIYLLEAPEEAVDRLRTTLDGLGDSLVVVGGDGLWNVHVHVDDPGAAVEAGVEAGRPYRIRITHFGDERRRASAPRAQRAVVAVVHGEGLAALCGEAGATTVPARPGEPLAVADLLDAIRRAHAREVVLLPGGAELRAAAAAAAEQARADGVRVAVIPTRSAVQGLAALAVHDPEAGFDEDVVAMTAAAGATRYGELAVAERQSFTSAGICQAGDVLGLIDGDVAVIGPGLPETAEAVLERMLGSGGELVTLVLGPEVPDTLAARLESYVQQRHLAVDTVTYSGGRHSAPLLIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZW9</accession>
    <name>A0A0F4JZW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945517.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39409">
        <property type="protein sequence ID" value="KJY39409"/>
        <property type="gene ID" value="VR44_01635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5728"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="29453" checksum="8DE8803657C78EAD" modified="2015-06-24" version="1">MEHQVFVPVPADDLRAVLRDPARVAGCVPGLQQDADAGAAPGAVAGRLRLRVGSSSVTYRGTLALAERDPEHFTAECEGAEVRGQGTVKLSAGLRLTPHEGGTRLEFTGEATADGRTAGLDAEALTTALRRLLDRFCANLAEAAGPEESGAEGEPGTGAASVFDTDVPPSSRNPFLDEGFTDLPDLPDFAGLPELGELPQTAGPGEAPAPADPTAPPNPPAEAAHARRTMIGRSAEEVDHAPPRGRYAPVPAPSAGGSGPALRWIAPAAALALASAVVVGRALRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K072</accession>
    <name>A0A0F4K072_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945798.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38646">
        <property type="protein sequence ID" value="KJY38646"/>
        <property type="gene ID" value="VR44_03140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7843"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15572" checksum="49A127B92826C49B" modified="2015-06-24" version="1">MEPLKVVARLWERIEARDWHGVAALVAEDAVIEWPVSGERIVGRTNFIAVLSDEGPDADERSVGTVEVLRILADGDLVVTEVEIPEDHVLYRAVSLWTVRDGEVVAAREYWTSPGQDPAPRWRAGYVEPLAAEAAGEDAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0B3</accession>
    <name>A0A0F4K0B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945263.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene988"/>
    <dbReference type="EnsemblBacteria" id="KJY40067">
        <property type="protein sequence ID" value="KJY40067"/>
        <property type="gene ID" value="VR44_00100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.20"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="79"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY40067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="40268" checksum="4AF7B78575F6F5C4" modified="2015-06-24" version="1">MLTGARLTDGRTVDVRLSGGRIQAVGTAGSLPAPAPARVDLRGYLLLPAPAEPHAHGDTALTADGEGPVSYARDEVQRRATEAALLQLGHGATAVRSHIRIGDVHGLGPMEAALQARRSLRGLTDLTTVAVPRLLTGVAGADGLAMLRDAVKMGASVIGGCPDLDPDPTGFLEAVLELAAEHGCPVDLHTDGDDPGRLARLAAMAGGLRPGVTIGPCGGLSRLPLDAASRAADQLAAAGVRVTCLPQGDCAALERRGLRTAPVRLLRAAGVRVAAGSGALRDAGNPVGRGDPLEAAYLLASQGGLRAAEAYDAVSAAAREAMALPEVRVEAGFPAELLAVRGDRIAGVLSLAYSRIVIHRGRVVARTSAVREYCDSAVAVALDLPRQGRMEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2F5</accession>
    <name>A0A0F4I2F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001828">
        <property type="protein sequence ID" value="KJY15874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15874">
        <property type="protein sequence ID" value="KJY15874"/>
        <property type="gene ID" value="VR44_40720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8119" checksum="900201DAD1D5B030" modified="2015-06-24" version="1" fragment="single">ALTRPPEGPPAPPGGARHTAAGRDRAPSGTSAPGADPAPGRSELVRLTWAQPEDLVGHELRQAAEDGRDAGPLLRAWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I303</accession>
    <name>A0A0F4I303_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001834">
        <property type="protein sequence ID" value="KJY15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15848">
        <property type="protein sequence ID" value="KJY15848"/>
        <property type="gene ID" value="VR44_40745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAsynt_C_assoc" evidence="1">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8009" checksum="2AF8D091567CF74C" modified="2015-06-24" version="1" fragment="single">GVAGIIKMVQAMRHGVLPRTLHVDAPSAEVDWSAGAVEVLAEQRPWPETGRPRRAGVSSFGISGTNAHVILEAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3J8</accession>
    <name>A0A0F4I3J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001738">
        <property type="protein sequence ID" value="KJY16560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16560">
        <property type="protein sequence ID" value="KJY16560"/>
        <property type="gene ID" value="VR44_40390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRSP" evidence="2">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="20667" checksum="5777D6EB16A717F9" modified="2015-06-24" version="1" fragment="single">MPYARVALEWPAGVPDGGRHGFTPAHREDLEAALPALAGQLAAALGEGPGRVLVLGNEELMYVPLRLAAALEERGAAAEVRFSSTTRSPVLAVDDPGYAIRTRLVFPAHDAPADGPGDRYAYNVAGGGFDAVVAVVDSAGDTPELHTGLLAALAPHTGRVVLAVVPSYAPDGPATPARPAAARAAATASGSPAVTAPGSPAAESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3T5</accession>
    <name>A0A0F4I3T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001786">
        <property type="protein sequence ID" value="KJY16123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16123">
        <property type="protein sequence ID" value="KJY16123"/>
        <property type="gene ID" value="VR44_40600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6961"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14517" checksum="B4258CC9370BF1F5" modified="2015-06-24" version="1" fragment="single">DQTGTPVATIDSLALRAVTTAQLEDGGALRDALFRVEWVEPVLGDGTGGDWVWLDEEDDTVPAYVVTRTPAGEVHSAVAEALRLVRSWLAGERFARSRLVFTAERQDPATAAVWGLVRSAQAENPGRFALVEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4Z6</accession>
    <name>A0A0F4I4Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001839">
        <property type="protein sequence ID" value="KJY15836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15836">
        <property type="protein sequence ID" value="KJY15836"/>
        <property type="gene ID" value="VR44_40765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="7466" checksum="E47E92DE22C9C6D7" modified="2015-06-24" version="1" fragment="single">LDVLSIPLLAAVAFLLGLGGLFFDTAATTYLPDLLGRDPALLERANSRLRGTQTAASGFAGPPAGSALLALGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6X8</accession>
    <name>A0A0F4I6X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001753">
        <property type="protein sequence ID" value="KJY16451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16451">
        <property type="protein sequence ID" value="KJY16451"/>
        <property type="gene ID" value="VR44_40460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6748"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="18171" checksum="52CDE62852852717" modified="2015-06-24" version="1" fragment="single">LHTAFAHRASYLTPGEPDTLPWLSHSTIELTRPGTRALALWATLHHLGRDGVTALLQHYLTLADHLREKITANSRLELVAGGPWPVACFRLTDTTATGPEADALHTRIAHHVQTAGRAYLATVTVDDRTVLRACLCNYRTRESDLDLLLREVLHAADSDRTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAY9</accession>
    <name>A0A0F4IAY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001563">
        <property type="protein sequence ID" value="KJY19157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19157">
        <property type="protein sequence ID" value="KJY19157"/>
        <property type="gene ID" value="VR44_39200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5640"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="16989" checksum="FBD37DBDABA974C9" modified="2015-06-24" version="1">MITQGVQITGRCSGCGGPTICDVGQFFHRGRLRWGSEGRCENCSDGWCEEDIGPVTPEHIRQALLQPHGPSRLRLSGEVPSPVPVLKALRDAGDGLSLGEARARASELAAGGLVGTLVEMEVLAVRLRARAVPVTVEPAGGSAVAAPTPHGPTAQAPDPPSYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBL4</accession>
    <name>A0A0F4IBL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001576">
        <property type="protein sequence ID" value="KJY18883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18883">
        <property type="protein sequence ID" value="KJY18883"/>
        <property type="gene ID" value="VR44_39330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="15988" checksum="ACA745408E320AE2" modified="2015-06-24" version="1" fragment="single">YGKAAARGGAEETMRRLTATDVCQPVLGTVQLAATRLLADCGITPDLALGHSVGEFAAAAAAGALTGEDTVRLLAGRGAALRQAAENGPPGGMLAVQTDEETCRRLVEGIDGVWLACFNEQRQIVVSGTARGLAALREACAGAGVVTVTLEVAGAFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIK4</accession>
    <name>A0A0F4IIK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_38680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001502">
        <property type="protein sequence ID" value="KJY20461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20461">
        <property type="protein sequence ID" value="KJY20461"/>
        <property type="gene ID" value="VR44_38680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5413"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Bac_transf" evidence="7">
        <location>
            <begin position="234"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY20461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="45101" checksum="A739C28612D9DBE3" modified="2015-06-24" version="1" fragment="single">ATAAAAVLLAAANAALQAQGGLYRPRLAPSALLELPALAGRTAALWCGAAAVLAAAAPARALPWNALLAAVCLHTVLACAGRGLVHRLWRRSAVRRPVSTLVVGPADGAGAVAAALHGRPEYGLRPVGIADPADPAAGEGGQLPVLATHEDVRRAVIQNSVRCAVFTRPPEADERTAALVRLFHDHGCRLWLADPAGTAKVTGMRVAHPADQLWGYAVQPLLPRPARPLERSVKRIIDSALAALALLAAAPVMGACALAVRLSDGPGVIFRQERVGLYGRPFTLLKFRTLRADEHESATRWTVAGDRRMSPVGSFLRKSSLDELPQLWNVVRGDMSLVGPRPERPFFVAKFSTVHPGYEARHRMPVGITGLAQINGLRGDTSIEDRARFDNHYIDTWSLWQDLWILARTAASFFRFRLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INV8</accession>
    <name>A0A0F4INV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001398">
        <property type="protein sequence ID" value="KJY23168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952177.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001398.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23168">
        <property type="protein sequence ID" value="KJY23168"/>
        <property type="gene ID" value="VR44_37670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="90"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27044" checksum="25B38ADC9554C60F" modified="2015-06-24" version="1" fragment="single">MSNWLLPTAPCTPQACAAHPGGRAASVPHAALRLAGALGLVLLAVPAAPAVRLLPAGPRRALIRTWCAALLRSLGIRITVRGTPGPDGGRLIVANHISWTDIPLVAAALPSRMLAKSEIGTWPVLGRLAAQAGTLFIERDRIRALPRTVGTIARALRAGDRVTVFPEGCTWCGRAQGPFRRAAFQAALDAEVPVQPVRIAYRLDGGEFAGAPAFVGEDTLTASLWRIARARGIRAEVRLLPRIPHGRHADRRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ61</accession>
    <name>A0A0F4IQ61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001354">
        <property type="protein sequence ID" value="KJY23814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23814">
        <property type="protein sequence ID" value="KJY23814"/>
        <property type="gene ID" value="VR44_37175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4825"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="10848" checksum="DAA69E6390BA7000" modified="2015-06-24" version="1" fragment="single">PSVGLDYLLPAFVGALLGSTTVRPGRANAIGTLVAVGVLAVGLAGIGQLGADFWATPLFNGGTLLVAVGLAGYSARRRLRTRAAADGPAPPAGDGPPRPPAHHQPPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQM4</accession>
    <name>A0A0F4IQM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S-adenosylmethionine synthetase</fullName>
            <ecNumber evidence="9">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_35660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01001246">
        <property type="protein sequence ID" value="KJY24335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24335">
        <property type="protein sequence ID" value="KJY24335"/>
        <property type="gene ID" value="VR44_35660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4230"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY24335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7704" checksum="40C708735922ED7A" modified="2015-06-24" version="1" fragment="single">AIGKAEPVGLFVETFGTGALPDERIQEAVSAVFDLRPAAIVRDLDLLRPIYAQTAAYGHFGRELPEFTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQP6</accession>
    <name>A0A0F4IQP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_35680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001248">
        <property type="protein sequence ID" value="KJY24327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951804.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001248.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3791"/>
    <dbReference type="EnsemblBacteria" id="KJY24327">
        <property type="protein sequence ID" value="KJY24327"/>
        <property type="gene ID" value="VR44_35680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4287"/>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="442" mass="47219" checksum="88465979FE95501E" modified="2015-06-24" version="1">MTTTTEQLSATTLLRFATAGSVDDGKSTLVGRLLHDSKSVLEDQLEAVERVSADRGQDAPDLALLTDGLRAEREQGITIDVAYRYFATARRRFILADTPGHVQYTRNMVTGASTADLAVVLVDARNGVIEQTRRHAAVAALLRVPHVVLAVNKMDLVDYRESVFAKIAEEFTAYASELGVPEITAIPISALAGDNVVEPSANMDWYGGPTVLEHLETVPVSHDLTACPARFPVQYVIRPQTAEHPDYRGYAGQIASGVLRVGEAVTVLPSGKTSVIEGIDALGESVDIAWSPQSVTLRLKDDIDISRGDLIAPTASAPATTQDVVATVCHVADQPLAVGARVLIKHTTRTVKAIVKEIPSRLTLDDLSQHPNPGQLVANDIGRVVVRTAEPLALDAYADSRRTGSFLLIDPADGTTLAAGMAGESFASQAEAVQADEEGWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQV1</accession>
    <name>A0A0F4IQV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001402">
        <property type="protein sequence ID" value="KJY23021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952185.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001402.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5419"/>
    <dbReference type="EnsemblBacteria" id="KJY23021">
        <property type="protein sequence ID" value="KJY23021"/>
        <property type="gene ID" value="VR44_37710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5048"/>
    <dbReference type="eggNOG" id="COG2425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35645" checksum="2E473C5088BCC9D9" modified="2015-06-24" version="1" fragment="single">GQGERSAGLGGSAPKVARWLGDIRTYFPTPVVQVMQRDAIDRLGLSTLLLEPEMLEAVEPDVHLVGTLLSLNKAMPDTTRETARAVVRKVVEQLEKRLAARTRATLTGALDRSARINRPRHRDIDWDRTIRANLKNYLPEYRTVVPERLVGHGRAAQSVKKEVVLCIDQSGSMAASVVYASVFGAVLASVRSIATRLVVFDTAVVDLTDQLDDPVDVLFGTQLGGGTDINRALAYCQSRITRPADTVVVLISDLYEGGIRDEMLKRVAAMKAAGVEFVALLALSDEGAPAYDREHAAALAALGAPAFACTPDLFPEVMAAALEKRPLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRU5</accession>
    <name>A0A0F4IRU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001235">
        <property type="protein sequence ID" value="KJY24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951776.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001235.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24389">
        <property type="protein sequence ID" value="KJY24389"/>
        <property type="gene ID" value="VR44_35530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="117"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20696" checksum="3CE43C66FF0643FC" modified="2015-06-24" version="1">MTSSFEFPAYPVPRLSDAERDRALGQLREGAALGKLSHDTFMRRMELALVARRSEDLAVLLADLQTREGPLGAESPWTHRLFGWVGRASAVSVGVRRAWQAERLPKLLLPHPAAGPLRIGRDPGNGLRLSHDTVSRAHAELSLRDGVWLLKDLGSTNGTTVNGRRVTGVAVVRVGDQVGFGRMSFRLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRZ8</accession>
    <name>A0A0F4IRZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.174</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2G1835 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmG</name>
        <name evidence="3" type="ORF">VR44_34285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10218"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.174" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001168">
        <property type="protein sequence ID" value="KJY24800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951552.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001168.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24800">
        <property type="protein sequence ID" value="KJY24800"/>
        <property type="gene ID" value="VR44_34285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3834"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052916">
        <property type="term" value="F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01859">
        <property type="entry name" value="23SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017237">
        <property type="entry name" value="rRNA_m2G-MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF5">
        <property type="entry name" value="PTHR47816:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037565">
        <property type="entry name" value="RRNA_m2G_Mtase_RsmD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="214"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="42636" checksum="A0BCFD629784161C" modified="2015-06-24" version="1">MTTPFGSYELTRFPADPRDRLRAWDAADEYLLRHLDAGTGERGPVDLAGAGQITVVGDRWGALTTALAAYHPAQITDSALARAATEANLDRAGIGTAKSTVTLLTTRDAPPARIDVLLVRVPKSLALLEDQLLRLAPHLHEGTVVVGTGMVKEIHTSTLELFEKIIGPTRTSLAEKKARLIFCTPDPALLSAAGTSPWPLTYTVDQDGGSGAGLTVVNHAGIFCADRLDVGTRFFLQSIPTNTNGARVVDLGCGNGVVGTAVQVADPDAEVVFTDESYQAVASARATYEANVRPGRRTAEFLVGDGVAMLPPSSVDLILNNPPFHSHQATTDATALRMFAQSRKVLRPGGELWVVANRHMGYHTHLRRLFGNCEVTASEPRFVVLRAVKREARQHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT47</accession>
    <name>A0A0F4IT47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_34725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001190">
        <property type="protein sequence ID" value="KJY24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951627.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001190.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24638">
        <property type="protein sequence ID" value="KJY24638"/>
        <property type="gene ID" value="VR44_34725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4010"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22309" checksum="0E13C1EADDE374E0" modified="2015-06-24" version="1">MNTPYQDAQRAGQAAVRTAILDHAIDLLVTEGAAALTMRRIASGIGASTKVLYTMFGGKEGLVDALYREGFARLRRAQQRAHRAEDPLTRLNDLAAAYRAHALAEPAYYRVMFEQAVPGYQPSAEALDAAESAFDASVEAVQACIDSGVFAPGDAREISKLLWAAAHGAVSLEIAGHFPPETAARRFHTLTAAVGQAFLADEHGQGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITA6</accession>
    <name>A0A0F4ITA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001102">
        <property type="protein sequence ID" value="KJY25245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951315.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25245">
        <property type="protein sequence ID" value="KJY25245"/>
        <property type="gene ID" value="VR44_33020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3476"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19073" checksum="C5A06E9FEEDD2579" modified="2015-06-24" version="1">MSEEQRDQSQSPAAPAEPPAGPQPEPIRFFGTSWVDHTDGYALRRAALAAGSLVGAAAGAYLLRLAYEGLEIGNVGPFLSISVIVLFAIATAIAFAKTWESFGRRPAPSSDEAALKGLKAIGFIGSLLAYFLRSLTEAPGEKLHRTEYERAAAEYERRRSTRTGNPAARRRPKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU13</accession>
    <name>A0A0F4IU13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001066">
        <property type="protein sequence ID" value="KJY25492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951193.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25492">
        <property type="protein sequence ID" value="KJY25492"/>
        <property type="gene ID" value="VR44_32345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3270"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470132" evidence="1">
        <location>
            <begin position="30"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="22642" checksum="56459B8E3465F007" modified="2015-06-24" version="1" fragment="single">MRLSRFAALTSSLLLAAGAALFGAGQAAAQADFGYVALGDSYSSGVGAGNYDSASGSCKRTTRAYPALWAAAHSPQTFSFTACSGARTGDVLSGQLGPLNSGTDLVSITIGGNDAGFSDVMTTCVLQSESTCVNRVNQAKAYVDSTLPGQLDQVYDAIRGRAPSAKVVVLGYPRFYQLNGSCIAGLTEGERSAINGASDYLNAAIAKRAADHGFTFAPVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUG4</accession>
    <name>A0A0F4IUG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001041">
        <property type="protein sequence ID" value="KJY25647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951116.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25647">
        <property type="protein sequence ID" value="KJY25647"/>
        <property type="gene ID" value="VR44_31930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3101"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16902" checksum="BD4D682C969DD816" modified="2015-06-24" version="1">MKRIGVTGHRTIPDGCLAHVEEGLRSALGGHPGPLEALSSLADGADQLFAAIALEYGAELTVVIPSGDYEDTFRDSRGLAAYRRLKDRATQEVLMGFPRSTDEAYYAAGTYIAESCDRLVAVWDGLPARGHGGTGEIVAYARALGKPVTVIWPEGAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUN0</accession>
    <name>A0A0F4IUN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951085.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25725">
        <property type="protein sequence ID" value="KJY25725"/>
        <property type="gene ID" value="VR44_31765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3064"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="14775" checksum="60BAE0CD653AE03B" modified="2015-06-24" version="1">MDIDAWVWWLIGAVGLGIPLVLTAMPEFGMFAVGAVAASVTAALGAGPVAQVLVFVIVSVALIAVVRPIANRHLNQRPQHRSGIEALKGRTAVVLERVDGSGGRIKLAGEVWSARALDTHSSFEPGQSVDVVDIDGATAVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX6</accession>
    <name>A0A0F4IUX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001019">
        <property type="protein sequence ID" value="KJY25835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951026.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25835">
        <property type="protein sequence ID" value="KJY25835"/>
        <property type="gene ID" value="VR44_31460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2785"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470283" evidence="2">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="21813" checksum="C64B179D8ABCD94E" modified="2015-06-24" version="1">MTPDTRRGFAVVALLTALITTATACGGSEPGPARTRDTTTTDTNTDTDTDSTASAPAPTGEDLGKIFPGTDSDSGTASTVALPRAQLDEPAGGTMELSNDQQVPLTVQPLRATSESGDLSIVKDGCSGVTLQPQQTCSVQVSHTAQEAGTWTGTVIAPTAEGPMFSVTLTGEAVEAATETATGSPTPEPTETSETPETSETPEESESPTPEPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUY0</accession>
    <name>A0A0F4IUY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001020">
        <property type="protein sequence ID" value="KJY25827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951031.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25827">
        <property type="protein sequence ID" value="KJY25827"/>
        <property type="gene ID" value="VR44_31485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2792"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="10649" checksum="9AA137F65203F655" modified="2015-06-24" version="1" fragment="single">AAADLRAAIGTPHAQEALTAIGRLAQLREALAVLAVALAGVHGRLAWFLGAAATALAPVLHWRALPDAQGPTFGAVEPTPEQYTDAEDAIRRLHSALARLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVF0</accession>
    <name>A0A0F4IVF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001073">
        <property type="protein sequence ID" value="KJY25438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951219.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25438">
        <property type="protein sequence ID" value="KJY25438"/>
        <property type="gene ID" value="VR44_32480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3300"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12626" checksum="F788070C2307AC29" modified="2015-06-24" version="1">MAVRRVVPNLQSQDADASREFYGLLGFEEVMNHGWIMTLASPSSPAAQISVMTGDRTAPVAPDMSVEVDDVDAAYAVMRASGAEIVHPLQDEEWGVRRFFVRDPTGRVVNVLGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVK4</accession>
    <name>A0A0F4IVK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001177">
        <property type="protein sequence ID" value="KJY24721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951589.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6928"/>
    <dbReference type="EnsemblBacteria" id="KJY24721">
        <property type="protein sequence ID" value="KJY24721"/>
        <property type="gene ID" value="VR44_34515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3887"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="294" mass="32010" checksum="2C7A1F11FB30D39D" modified="2015-06-24" version="1">MQHGPAVRRRKLGEELRALRDRTGLTSGEVARIVGWHQSKVSRIETGRSGVKTQDIRLLLDAYGDVVGPQQRALLEALGASAAGPGAGGEEARGRQWWHDYRGLLPQEYRDFISLEAGARSARTVELSVVPGLLQTAEYARAVTRAALGGLPEPKVDALVDVRLARQAVLRADPPLELSAVLDEAVLRRQIGGPGVMREQLRHLAEVARLPQVHLQVLPFTVGGHLGLTGPFVIFSFPNIADLDVVVLDHLTSSLYLERKEDLEAYSAAFRTIQAHALPPRDSSDLISSLAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVX2</accession>
    <name>A0A0F4IVX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001050">
        <property type="protein sequence ID" value="KJY25603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951147.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25603">
        <property type="protein sequence ID" value="KJY25603"/>
        <property type="gene ID" value="VR44_32070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3132"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="627" mass="67526" checksum="49F3E34AD2E78F37" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWD3</accession>
    <name>A0A0F4IWD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">VR44_30275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000952">
        <property type="protein sequence ID" value="KJY26337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950812.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000952.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26337">
        <property type="protein sequence ID" value="KJY26337"/>
        <property type="gene ID" value="VR44_30275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2465"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="267"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY26337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="41787" checksum="9ED3F299D6613BCA" modified="2015-06-24" version="1">MKFLHTSDWHLGRSFHRVNMLGAQAAFVDHLVEAVREHAVDAVLVAGDVYDRAVPPLPAVELYDRALHRLADLGVPTVMISGNHDSARRLGVGAGLIGRAGIHLRTDPAGCAEPVVLADAHGDVALYGLPYLEPALVKEEFGAEKVSHEAVLGAAMDRVRADLAGRPEGTRSVVLAHAFVTGGQASDSERDIAVGGVEAVPASVFDGVDYAALGHLHGCQTINERVRYSGSPLAYSFSEAGHRKSMWLVELGPAGEITAERLDTPVPRPLARLRGRLEDLLEDPALTGREDSWVEAVLTDPVRPQDPMARLTARFPHTLSLAFEPEGRRDEGAASYAQRLRGRSDQEIAEDFVAHVRGGGTADEAERAVLRAAFEDVRAEDGRLETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX52</accession>
    <name>A0A0F4IX52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_32990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001100">
        <property type="protein sequence ID" value="KJY25261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951309.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001100.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3203"/>
    <dbReference type="EnsemblBacteria" id="KJY25261">
        <property type="protein sequence ID" value="KJY25261"/>
        <property type="gene ID" value="VR44_32990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3418"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27276" checksum="60F76C26555C630A" modified="2015-06-24" version="1">MARNIQSLERAAAMLRLLAGGERRLGLSDVASALGLAKGTAHGILRTLQAEGFVEQDPASGRYQLGAELLRLGNSYLDVHELRARALVWTDDLARASGESVYVGVLHKSGVLIMHHVFRPDDSRQVLEVGAMQPLHSTALGKVLSAYDPVAHTEALDAEREAFTPRTVTDAAGFEEVLDLTRARGWAADVEETWEGLASVAAPIHDRRRMPVGAVAVAGAVERVCGESGEPRPALVAAVRDCARSVSRDLGAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX91</accession>
    <name>A0A0F4IX91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000961">
        <property type="protein sequence ID" value="KJY26269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26269">
        <property type="protein sequence ID" value="KJY26269"/>
        <property type="gene ID" value="VR44_30520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2519"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="16671" checksum="F78A7EDE768A9DD0" modified="2015-06-24" version="1">MAERGHRALGIDVTPAAVTRTVRRGGTALCRSVFEPLPGERRWDTALLIDGNIGIGGDPAALLGRTADLLAPGGRLVAEAAPVEVDERCEVRLDDGRGTLGTPFPWARAGRRALLRHAEAAGWRTVGSWTVAGRHFAELVPGRRRTAAAARTAPGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXB9</accession>
    <name>A0A0F4IXB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000913">
        <property type="protein sequence ID" value="KJY26657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950674.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000913.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26657">
        <property type="protein sequence ID" value="KJY26657"/>
        <property type="gene ID" value="VR44_29515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2276"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="82"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="34369" checksum="E85A4D9E185DDC72" modified="2015-06-24" version="1">MPDRPVLEAAAQAFADATAKPPFLYEIPVADGRRAVEGVQSGEGVDLPPVDEEWIVVPGGPTGQVRTRIVRPHGATGTLPVILYVHGAGWVFGDARTHDRLVRELAVGAGAAVVFPDYDRSPEARYPVAIEQNYAVARWITTDGAAHGLDPARIAVAGDSVGGNMSAALTLMAKERGDVRLRAQVLFYPVTDASFDTGSYEEFAEGYFLRRDAMRWFWDQYTTDPAERARPTASPLRATAEQLTGLPPALVVTAEADVLRDEGEAYAARPRLREAGVPVTALRVLGTIHDFVMLDALRDTRAARLAVGLAADTLREALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXU6</accession>
    <name>A0A0F4IXU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001068">
        <property type="protein sequence ID" value="KJY25481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25481">
        <property type="protein sequence ID" value="KJY25481"/>
        <property type="gene ID" value="VR44_32370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3276"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="201"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="41826" checksum="65E3B80AAB4E23B7" modified="2015-06-24" version="1">MCRVSEDVPLLDDLMPWSVSGLRLGRAWVAAPDPATLRARWTALTGAEGPERERLFRPSRTRTPSAGAAALPGQRSATARFADDPGPFPDPVRVLRAPFDEQWLLPDQRLIDAARPELWRVLDGQQLFLLENPGLLVTAHLPAGRLGRIRPLHRRPGGTEANLAPGLAPLLGGRYGGWVTPEDVLCWILAAGRPGIRGYEVPLPADPGRWRAGVELGHRLLTVQLRGARGGEPPRLPGGRRPYVRAAVTVWPQELGYDPETETLTVGDGAVSPVPAGAWEYEAQGVRVLESWFAARCAHREPEARGLEGFGPAEWPQAWTSDLLALVTTLALLADLAPERAAFTPGPPLPPAELAAAGVLPPPRWSRRPASVLDHQEEGPGGQFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXV4</accession>
    <name>A0A0F4IXV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000894">
        <property type="protein sequence ID" value="KJY26880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26880">
        <property type="protein sequence ID" value="KJY26880"/>
        <property type="gene ID" value="VR44_29025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13309" checksum="A6311F3713A7B2AE" modified="2015-06-24" version="1" fragment="single">MSEIKLSAKLRDTFGKGSARQSRRDALTPGVIYGHGTTPKHVGVEAHALMMALKTPNALLSLDIEGDGTELVIPKAVQRHPLKRNILHVDFLIVQKGEKVTVEVPVVTEGDLAPGGNLLETLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYM2</accession>
    <name>A0A0F4IYM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950477.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000868.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1152"/>
    <dbReference type="EnsemblBacteria" id="KJY27125">
        <property type="protein sequence ID" value="KJY27125"/>
        <property type="gene ID" value="VR44_28430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2011"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16512" checksum="6704CEE0D1DA5086" modified="2015-06-24" version="1">MPGSPELLRSVFRRHAAGVAVITAQSGGRPAGFTATSLNSVSADPPMLSFTIGTGASSWPAVRDSDHLGVHILGEHQQDLAGLFARSGADRFGPGTDWAPGPHGVPLLDGVLAWLVCRVVARVPAGAHRVIIAEAVAGDPAGEGRPLLYHQGRFNALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZC4</accession>
    <name>A0A0F4IZC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26989">
        <property type="protein sequence ID" value="KJY26989"/>
        <property type="gene ID" value="VR44_28690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2069"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="11642" checksum="EC5BE8368095BB5C" modified="2015-06-24" version="1" fragment="single">MALDEAVRELVDGRNFAVVATLNPDGGPQTSVVWVGRRGDDVVFSTTAGRKKARNLARDPRISLTVYDRENPYRSVEVRGTAELLPDPHKELPRELSRHYLGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Q0</accession>
    <name>A0A0F4J0Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950140.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27860">
        <property type="protein sequence ID" value="KJY27860"/>
        <property type="gene ID" value="VR44_26610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1447"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19753" checksum="BC5E81FD65EF7B3D" modified="2015-06-24" version="1">MPTAQPAALSFRSAVEEDVPALVALVESAYRGDASRAGWTTEADYLDGQRTDPSGVGAIIADPDSTLLVVERGAELVACCQLEHRGDHAYFGMFAVRPGLQGAGLGKEVMAEAERRAREDWKVAEMRMTVVNVREELIAYYERRGYRRTGELSPFPYGDERFGIPLRDDLAFELLVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0S6</accession>
    <name>A0A0F4J0S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Forkhead-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000932">
        <property type="protein sequence ID" value="KJY26506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26506">
        <property type="protein sequence ID" value="KJY26506"/>
        <property type="gene ID" value="VR44_29920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2365"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25547" checksum="92F151572485B668" modified="2015-06-24" version="1" fragment="single">GAPPSAPPPPPPVPPQPVYSQDHFEYQGSRPSRVNRRAEPLLDEDDWLLPPPAPAAPVPPAPPVQEPVPAPVQAPAQAPVQAPVPAPVQPPVQAEYPLPPVAEEPVGSGSWTATIGPDRAYFMAMMRRSGPEAAGLNLPAYSPELHLPLVGGQITIGRRRASTGESPDVDLSVPPEDPGVSHSHAVLVQQPDLSWAVVDQNSTNGTTVNMGEEPIQPYVPVPLADGDRVHLGAWTTITIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2H0</accession>
    <name>A0A0F4J2H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000005_gene3920"/>
    <dbReference type="EnsemblBacteria" id="KJY27923">
        <property type="protein sequence ID" value="KJY27923"/>
        <property type="gene ID" value="VR44_26460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1476"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="51065" checksum="8A30607019231FF0" modified="2015-06-24" version="1">MGFLDALVIGLNSTSPAYSLAAVIGPIVAIAGIYAPGVMLASFVPMLLIAAAFYYLNKVDQDCGTTFSWVTRAMGPWAGWLGGWAITMTGVLVIGSLADVAVHFGLLAFGLDGLAANTVVRQTLAVVLILAMTAICVIGTELSAHFQDVLILAQVLFLLVFAVVAIYRVYAGTSTLDALHPSVSWLNPFGAGGSALTGGLLLGVFIYWGWESAVNLTEEVEDSATAPGKAGIWSTLILLVTYLSVGFAIVAYAGTKFLAENADEEEEIFAVLAHEVMGGWDWMVLLAVCTSALASTQTTIIPASRTALSMARRHALPPHLAHIHHRFHTPDVSTWWVAAIAIAWYLAVNQISENALLDSLTALSLLIAFYYALTGVACAVYYRRHLLENAHNFLLIGVGPLVGAGLLAWLLVESVEDMSNPRNSAGGVSWFGLGPPLVIGIGIAAAGVLLMCFWRIRDGRFWQERRGVVDPALVHGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2U8</accession>
    <name>A0A0F4J2U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase VR44_27940</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_27940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000851">
        <property type="protein sequence ID" value="KJY27286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950386.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000851.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27286">
        <property type="protein sequence ID" value="KJY27286"/>
        <property type="gene ID" value="VR44_27940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="415" mass="45307" checksum="7E20C243B08C61B9" modified="2015-06-24" version="1">MSADIRPIAESELPEWLRAVNTGFLQPAPFSDSDVAQRAKYTDFARTQGAFDAVTGRCVATFRSFAQELTVPGGAAVPASAVTNVSVSPTHRRQGLLTRMMATELRAAKERGEVVSTLIAAEYPIYGRYGYGPATGTAEWEIDIARSGVDPRWSGPGDGGRIDLIDVSEAREAGPLLHERLRAVSHGTVSRNTRWWNVVTGVEQQFSARGYKDKFYALYRDAAGEPAGLAMYSADEHWTDAKIPQITLTVRDLIALTPDAERALWRFLCSIDWVMKVRTGYRAPDDIVPLLLPDPRAARPVTTADFMWLRLLDVERVLAARTYAVPGVLVLEVADAAGLADGRYRLDAAAGTCVRTEDPADLRLDVSVLGSLYLGDESAVRLAALGLVTEERPGALALADAVFRTARRPWCPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2V9</accession>
    <name>A0A0F4J2V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000719">
        <property type="protein sequence ID" value="KJY28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28550">
        <property type="protein sequence ID" value="KJY28550"/>
        <property type="gene ID" value="VR44_25045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7683" checksum="0E97F68B001F2206" modified="2015-06-24" version="1" fragment="single">MPVLSMGWRRQAFLHWPYRPHDVQALLPPGLQADLFEGRAWVSLTPFVMSTVRVCGMPMIPDTFPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2Z1</accession>
    <name>A0A0F4J2Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000850">
        <property type="protein sequence ID" value="KJY27306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950385.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000850.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27306">
        <property type="protein sequence ID" value="KJY27306"/>
        <property type="gene ID" value="VR44_27930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="144"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="34925" checksum="8D8A75FDE2E1813A" modified="2015-06-24" version="1" fragment="single">MSHRNARLTLHGRRILVERVLAGRPVAHVAAEMGISRPTAHKWIRRWRAEGEAGLADRPSRPRTTPHRTPVTAEARVCRLRIDRKLGPARIGPVLGLPASTVHRILVRHGINRLAFLDRPTGRVIRRYERARPGELVHVDIKKLGNIPNGGGHRVMDRRQAMDNKIAATARRKSSKPVIGYSFIHSAVDDHSRLAYSEVLPDERKETAAGFWTRANAFFAAHGITVERVLTDNGSCYKSKLFAQTLAAAGITHKKTRPYRPQTNGKVERFNRTLLDEWAYQRPYKSNDERTAALADFLHTYNHHRCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J415</accession>
    <name>A0A0F4J415_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000719">
        <property type="protein sequence ID" value="KJY28554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949854.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000719.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28554">
        <property type="protein sequence ID" value="KJY28554"/>
        <property type="gene ID" value="VR44_25070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1104"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14821" checksum="4C48D409EB2F5A76" modified="2015-06-24" version="1">MEVPPSATRHCELVPGPTRDTAEFGAWIAWVRQKLTDWHLSAHDADAVLIAAELLSNATRHAGGILRLTLDHHDGVLRIAVTDPSRIPPRPPRHRPESTGGHGLFIINSLTLRWGTRPERDGKTVWADLSAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Y8</accession>
    <name>A0A0F4J4Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000700">
        <property type="protein sequence ID" value="KJY28818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949742.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000700.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28818">
        <property type="protein sequence ID" value="KJY28818"/>
        <property type="gene ID" value="VR44_24465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.888"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="55" mass="5558" checksum="574B08BD47ACECEF" modified="2015-06-24" version="1">MTAVTETVYKVTGMTCGHCEGAVTAELTVVSAAPLAEADVRAAVDEAGYELAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Z2</accession>
    <name>A0A0F4J4Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000644">
        <property type="protein sequence ID" value="KJY29417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949476.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000644.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29417">
        <property type="protein sequence ID" value="KJY29417"/>
        <property type="gene ID" value="VR44_22995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7383" checksum="CD3C327191F642F1" modified="2015-06-24" version="1">MPKVPDGYVRVRSHLRRKPGPKSAKGLSVWAIAGLCAVVWLWGQIFGFGDSSAEQRPAPKPGVSAPAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5W6</accession>
    <name>A0A0F4J5W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000741">
        <property type="protein sequence ID" value="KJY28316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949957.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000741.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28316">
        <property type="protein sequence ID" value="KJY28316"/>
        <property type="gene ID" value="VR44_25620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1223"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="40421" checksum="0F96D32FAF64E1F7" modified="2015-06-24" version="1">MSVRQRHAVVAGAGIGGLTAALALTRQGWKVTVCERAEGPSAAGAGIVLAPNALRAFDAIGFDPAPGPGRAPAMAMCLRRPGGGRLNRADPAALAARYGRTPLALHRAALTAALAAGLPEGALRYGAAVTAVDGDEGRAVVRTTAGDLTADAVVAADGIHSPLRRRHFPQHPGLRYSGETAWRTVLPAAAVPAGVEAAETWGRGERFGTVPLADGGLYVYATAVVPEGYRPADVRTELLRRFGTWHHPVPALLERTDPARVLQHDLYDLAAPLPRLHHGRIAWIGDAAHAMTPNLGQGGCQAVEDAVVLAHLLARPDVPAALAAYTRARLARTDAIRVRARRAGRVAALGHPVAVAARDLVLRAVPARASLRALDDLFNGFALPGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6K9</accession>
    <name>A0A0F4J6K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000719">
        <property type="protein sequence ID" value="KJY28551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28551">
        <property type="protein sequence ID" value="KJY28551"/>
        <property type="gene ID" value="VR44_25050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="7015" checksum="E6B13DB348321D42" modified="2015-06-24" version="1">MKSAIPFAFSQRAISAFRPVRARKVSSWMSQATTSTSLRAACTSSRDPRVVSLSRPTGVRCTVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N6</accession>
    <name>A0A0F4J7N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000618">
        <property type="protein sequence ID" value="KJY29773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29773">
        <property type="protein sequence ID" value="KJY29773"/>
        <property type="gene ID" value="VR44_22120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="857"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="937" mass="98194" checksum="1C3A13DEFEAF6B29" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Q0</accession>
    <name>A0A0F4J7Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949296.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000615.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29788">
        <property type="protein sequence ID" value="KJY29788"/>
        <property type="gene ID" value="VR44_22030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.286"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20903" checksum="FA339061ACBC9484" modified="2015-06-24" version="1">MLVYSMSVSVDGFIKDREGAFDWSGPDDEQFRVHLEQTGELGGFLCGRRLYETMLPWETDPSLREDELRSAFADVWCALPKTVFSRTLGSVRGNARLARLPVAEEAAAAREATGKDIGIGGAGLAATAIGLGLVDELRMFRYPVVVGGGTPFLPPVTEDIRLNLLETRTFGSRVVYERYERARDPFPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7W9</accession>
    <name>A0A0F4J7W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949266.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29863">
        <property type="protein sequence ID" value="KJY29863"/>
        <property type="gene ID" value="VR44_21880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.256"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24853" checksum="7BC224DC7A7A11BA" modified="2015-06-24" version="1">MTNRFSDAFLSEAERHAAWGAEQLHVLGSFLPGGPWTAELSSCTYQQGGLELRVAVLGTYDRDERSWMWGWANPGWRGEEVVALTEAVERYGRAHGIPELAAEVVDLAGFDDPDRAAEMLAFTGMGVVGAPGYLGQMAGPGTRVYFLPDDPRVPRAALEPVALPRVLLTGAGLIGHSAPQVVRGFFEHHGVPYRTEDGGGRIVAELPDGNAVEVGFDGLGRISGVGVDRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7X6</accession>
    <name>A0A0F4J7X6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949272.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29868">
        <property type="protein sequence ID" value="KJY29868"/>
        <property type="gene ID" value="VR44_21875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.255"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="22608" checksum="4632AB64689DF764" modified="2015-06-24" version="1">MQKFATTAPVSAVLDIPAGRIQLIAADRADTTVEVRPANPSKSRDVKAAEQITVDFREGVLRVAAAPAKNRLLGNSGAVEVTVQLPAGSRVEAKAAAADLRGVGRLGDVVFDGAQAQVKLDETASARLTVQAGDVALGRVGGPAEVSTQKGDITIAEAVRGTVTLTTQHGDISVGAARGVSATLDAGTGYGRIGNALNNTDGPAAALTIRATTSYGDINARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9H0</accession>
    <name>A0A0F4J9H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">VR44_20555</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949018.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1088"/>
    <dbReference type="EnsemblBacteria" id="KJY30408">
        <property type="protein sequence ID" value="KJY30408"/>
        <property type="gene ID" value="VR44_20555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8822"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="365"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="389"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY30408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="499" mass="52485" checksum="1B7F3D399DB8FD13" modified="2015-06-24" version="1">MTADGVPDKFAALGLTYDDVLLLPGASDMAPDEIDTSSLISRNVRVNVPLLSAAMDKVTESRMAIAMARQGGVGVLHRNLSIADQANQVDLVKRSESGMVTDPITVHPDATLREADELCAKFRISGVPVTDPAGKLLGIVTNRDMAFESDRSRQVREVMTPMPLVTGKVGISGVDAMELLRRHKIEKLPLVDDAGVLKGLITVKDFVKAEKYPNAAKDKDGRLLVGAAVGVAGDAYERAQALIEAGADFIVVDTAHGHSRLVGDMVAKIKSNSSVDVIGGNVATRDGAQALIDSGVDGIKVGVGPGSICTTRVVAGIGVPQVTAIYEASLAAKAAGVPVIGDGGLQYSGDIAKALVAGADTVMLGSLLAGCEESPGELLFINGKQFKSYRGMGSLGAMQSRGDRKSFSKDRYFQEGVGGDDKLIPEGIEGQVPYRGPLSAVVHQLVGGLRQSMFYVGGRTVPELQDRGRFVRITSAGLKESHPHDIQMTVEAPNYSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA63</accession>
    <name>A0A0F4JA63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949269.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29866">
        <property type="protein sequence ID" value="KJY29866"/>
        <property type="gene ID" value="VR44_21895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.259"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="33055" checksum="2BC6F7EBA9A780B7" modified="2015-06-24" version="1">MRTELTDTTSSKIDRALLAARRAVGSPTMGLVLTLVVVTDEENAYDAVRAASEASREHPCRIIAVIKRTHRRRRRTRLDAELRVGSDAGSGEIVILRLHGELTTQAGSIVLPLLVPDAPVVAWWPADAPADPARDDLGALAQRRITDAQAAADPVGVLADRAAAYAPGDTDLAWTRLTPWRSLLACAFDQRTLPVTAAAVESEADNASAELLARWLEDRLGVQVARVATDGPVITRVRLETSAGEVVVDRPTGSLATLVLPGWPDRKVALKIRSTAELIAEELRRLDADEVYASALRSKGPARVALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAV7</accession>
    <name>A0A0F4JAV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31482">
        <property type="protein sequence ID" value="KJY31482"/>
        <property type="gene ID" value="VR44_18085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8164"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470771" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="16298" checksum="4A715B6F8CA9F73B" modified="2015-06-24" version="1" fragment="single">MCTAALAASLTTAAVVTNTPVAGAGEAEPTPDSPQAAERGDARLDLPGQLADPVVPPAAGGTAAEGAAGIPATALDAYKRAEVAVAAALPKCKLPWQLIAGIGRVESVHASGYGLKDDGTTERPIRGPRLDGNGFAKVLDTDKGEFDGDTEYDRAFGPLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC76</accession>
    <name>A0A0F4JC76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948604.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31353">
        <property type="protein sequence ID" value="KJY31353"/>
        <property type="gene ID" value="VR44_18325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8214"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9705" checksum="A514F4D4474C8C67" modified="2015-06-24" version="1">MRATSDPLTNDEKTELDEALKAVRRAEQALARAQAHLNRMAGRIGSADRYGQKAAVGRRVGWSRQHVTALANAYRAGELDQEERTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDU9</accession>
    <name>A0A0F4JDU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948174.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32395">
        <property type="protein sequence ID" value="KJY32395"/>
        <property type="gene ID" value="VR44_16045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7630"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="37452" checksum="B126E146785B6C1A" modified="2015-06-24" version="1">MARRIGIKDVAAAAGVSTATVSHVLNRVEGKRISEETRQRVWKAAGELGYAPNGLARGLRMQRSQTIGFVSDEIATTPHAGRMILGAQEAAAAEGLVLLLVNTSGDAELERASIDMLLQRRVDGVLYAAMYHRTVELPDALRATPTVLLDAGSADPAVPSVVPDEVQGGYAAVRELTDHGHRRIGMIVQTVDLPARQGRLEGYRRALAEVGVVYDPSLVAAETAVPFNTVGGDVEAGYRAARRLLTTERRPTALFCFNDRMAAGAYRAAAELGLTIPGDLSVIGFDNQELVCESVHPQLSTVQLPHYEMGARAVAQLLALTKSPGRPPGPGMNELLPCPLVARASVASPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEI6</accession>
    <name>A0A0F4JEI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948106.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32605">
        <property type="protein sequence ID" value="KJY32605"/>
        <property type="gene ID" value="VR44_15685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7539"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470988" evidence="2">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20320" checksum="4B30B4C4E1C8819E" modified="2015-06-24" version="1">MDPHRATARTPVAAAAAVATAAVAAALAAAHYDRPGGPDLAAELNHPVLLAALAALALTGAALLTSRRPAARKAAGLGLAGAVMCGVLAVPAYGVAADPFPDREWDVPAPDGSGRRLVVERDLGLGDPAWSVHIVTGTFPTARRWPVASYTPGHPRGVLQAEWRDPSHIRLIDLDHTHHDLRVAPNGRPLDALDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JER4</accession>
    <name>A0A0F4JER4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_15450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3291"/>
    <dbReference type="EnsemblBacteria" id="KJY32690">
        <property type="protein sequence ID" value="KJY32690"/>
        <property type="gene ID" value="VR44_15450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7491"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="23118" checksum="381A7B8BDCF9D323" modified="2015-06-24" version="1">MTWSEMQPLLTQGTYDTLYMVLWSTLVTVLGGLPIGILLVLTDKGGLLRNQPLNKALGVIVNIGRSLPFIILLIALIPVTTAVVGTFIGPTAMIVPLAIGAVPFFARLVETAVREVDHGLIEAVESMGGGIPTLVGKVLLPQALPSLVAAVTTTVITLVGYSAMAGAVGGEGLGSKAITYGFQRFETGFMVATVVVLIALVTVIQLIGDGVVRVLARRGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF68</accession>
    <name>A0A0F4JF68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000479">
        <property type="protein sequence ID" value="KJY31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31626">
        <property type="protein sequence ID" value="KJY31626"/>
        <property type="gene ID" value="VR44_17765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8049"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15335" checksum="0CCC24F5B5AF21BD" modified="2015-06-24" version="1">MGPYGPDMTETHHTLSVPAADATLQPQVLSGPSFGQDLVRTLHQATSVVGGLSFHDVETSDIEVSAFGAIVCTGDTPADALQAAAAVARQAPGLEIHALAWARTDGPREGTFEYKVTMTVTAPDPATGEHSGATHQERGRHLLGQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFK8</accession>
    <name>A0A0F4JFK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">VR44_14835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000379">
        <property type="protein sequence ID" value="KJY32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008738981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000379.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2591"/>
    <dbReference type="EnsemblBacteria" id="KJY32975">
        <property type="protein sequence ID" value="KJY32975"/>
        <property type="gene ID" value="VR44_14835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7364"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="36287" checksum="25FF5D60CE575BC6" modified="2015-06-24" version="1">MSFIGRDMAIDLGTANTLVYVRGRGIVLNEPSVVAINTNTGGILAVGSEAKKMIGRTPGNIVAVRPLKDGVIADFEITERMLRYFILKIHKRRYLARPRVVVCVPSGITGVERRAVIEASTQAGARQVHIIEEPMAAAIGSGLPVHEATGNMVVDIGGGTTEVAVISLGGIVTAQSIRVAGDELDNAIIQHIKKEYSLLLGERTAEQIKITIGSAYDLDKDEHTEIRGRDLVSGLPKTVVISAAEVRKAIEEPVNAIVDAVKTTLDKCPPELSGDIMDRGIVLTGGGALLRGLDERLRRETGMPIHIAEDPLDSVALGSGKCVEEFEALQQVLDAQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGB8</accession>
    <name>A0A0F4JGB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_14005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947806.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33397">
        <property type="protein sequence ID" value="KJY33397"/>
        <property type="gene ID" value="VR44_14005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7104"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470913" evidence="6">
        <location>
            <begin position="26"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="147"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="39793" checksum="F5780E88C4FDBBAA" modified="2015-06-24" version="1">MRTLARLAAAALLTATPVTAGTASAAGPEPTPAPLHTAVNAVPGQYIVTLQKGVDAAKTAQKLGLKPAFVYTSAMNGFAVPLTPLQLTIVRNSLGVKAVEEDARVQSVPTPSSRAGVRAPAASWGLDRIDQRSLPLNDEFITHGNGAGVTAYILDTGIDYAHSEFGGRATFGFDAMGDGQGGQDCNGHGTHVAGTVAGSTYGVARKANLVSVRVLGCDAKGSWSGIIAGMDWVAKNATQPAVLNASLGGDRSQAVNDAATALSDAGVLPVVAAGNSAKDACTVSPASAARVVTVGATDWFDQEASFSNYGSCLSLYAPGRDILSAKLGGGSVALNGTSMASPHVAGVAALYKAAHPKADPAELKQFLDHTSTKDVITNIGEGSPNKLLFTGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGF3</accession>
    <name>A0A0F4JGF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948340.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6028"/>
    <dbReference type="EnsemblBacteria" id="KJY32036">
        <property type="protein sequence ID" value="KJY32036"/>
        <property type="gene ID" value="VR44_16870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7810"/>
    <dbReference type="eggNOG" id="ENOG5031N2N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="10346" checksum="D5C5D25D4E9864E2" modified="2015-06-24" version="1">MATLHERKTYRDQVLRVLYEAVEGNRLLGITGAQLRRDLHVPEPDLAAACTYLAGEGLITVDWEPGNTPAMVTLTHEGIRRMEAEEEGTATGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGH3</accession>
    <name>A0A0F4JGH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948321.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000445.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32061">
        <property type="protein sequence ID" value="KJY32061"/>
        <property type="gene ID" value="VR44_16820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12937" checksum="BB4D1A9445995E8C" modified="2015-06-24" version="1">MGGEGAARRGMLAPVLANLALGVPAVVPLYLAWWTLTEYLPMDCHSTADLSRPDLGDCDFHTLDHSTAVLFLLVVTGVLLLGAVFVVDAVLPPKARRGTWLRSAALVPVPFALLLALAYNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH37</accession>
    <name>A0A0F4JH37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947883.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33119">
        <property type="protein sequence ID" value="KJY33119"/>
        <property type="gene ID" value="VR44_14435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="1">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14800" checksum="34EB457ECD8D86BA" modified="2015-06-24" version="1">MTERKPPGVSFESFVDRQIREAADRGEFARLPGLGKPLASLDAPYDELWWIKGKLHREGFSPLPPALALRKEAEDAREAALAAPTEAGARAVLAEINEKIRAALRRPPPGPPLKLAEFDVEAVLAQRRTARPSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHT2</accession>
    <name>A0A0F4JHT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000340">
        <property type="protein sequence ID" value="KJY33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33765">
        <property type="protein sequence ID" value="KJY33765"/>
        <property type="gene ID" value="VR44_13335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6903"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="184"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="579" mass="60713" checksum="2CED7443EC569074" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHU0</accession>
    <name>A0A0F4JHU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000408">
        <property type="protein sequence ID" value="KJY32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32511">
        <property type="protein sequence ID" value="KJY32511"/>
        <property type="gene ID" value="VR44_15835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7575"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8919" checksum="5FB991CC514E5B01" modified="2015-06-24" version="1" fragment="single">PTQRPLTEPERALSDRMVAYWTTFARTGSPNGPDAPPWPVLRSAGPRDQPVLSLAAGPGGIRPTDADSAHHCPFWDTVEGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHZ7</accession>
    <name>A0A0F4JHZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000334">
        <property type="protein sequence ID" value="KJY33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947646.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2346"/>
    <dbReference type="EnsemblBacteria" id="KJY33835">
        <property type="protein sequence ID" value="KJY33835"/>
        <property type="gene ID" value="VR44_13140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6691"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="28112" checksum="FAFF32B2A0B9A5EF" modified="2015-06-24" version="1">MAENNRGRVPTVIADDVHIVYRVNTGSSGKGSATAALSKIMRRGNRDAPGVRRVHAVRGVSFTAYRGEAIGLIGSNGSGKSTLLRAIAGLLPCESGKVYTDGQPSLLGVNAALMNDLTGERNVVLGGLAMGMSREQIKERYQDIVDFSGINEKGDFISLPMRTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQVRSEARIRELREKAGTVFLVSHNNNSIRDTCSRVLWLEKGELLMDGPTEEVVAAYEKASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI91</accession>
    <name>A0A0F4JI91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000316">
        <property type="protein sequence ID" value="KJY34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947560.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000316.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34067">
        <property type="protein sequence ID" value="KJY34067"/>
        <property type="gene ID" value="VR44_12665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6612"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="45048" checksum="83B3F9246C125252" modified="2015-06-24" version="1">MEENSWDLGIFEQAVRAYAHFQAPVADLKGPGFNVLGDHFSPVIALIAPLYRLFPGPATLLVAQAALFALSALPVTRAGARLLGPARGLALGAAYGLSWGIQQAVAFDFHEICFAVPLLAFALEALLARRWRAALAWGLPLLLVKEDLGLTLAALALVVAWRARRTDRRAARAAFAVAVGGTVAAVLVFTVVVPAFAPDGYAYWEKVGGPGGVLDGLGTKLTTLGWLLVPTTGLLALRSPLLWVAVPTLGWRFTSSEPYFWSTDWHYSAVLMPVVALALADSLDTARRSPRPWMRSYAHQLPGAVLAAALALSATSLPLARLGERAAYEKPARAAEAERLLARIPDGVTVEADYPALTRLTSRCRVFWLGGTRGVRPAYLVFDNSSGRVGDPLAYAGRLHPGSRFALVGEAGGMVLLERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIF0</accession>
    <name>A0A0F4JIF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15255</name>
        <name evidence="2" type="ORF">VR44_15280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948027.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000395.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32746">
        <property type="protein sequence ID" value="KJY32746"/>
        <property type="gene ID" value="VR44_15255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32751">
        <property type="protein sequence ID" value="KJY32751"/>
        <property type="gene ID" value="VR44_15280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7387"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="8248" checksum="7F5E6EA4F31D14F3" modified="2015-06-24" version="1">MSQCKIPDYRTGHRGRHWTHALRSAEKAGAVVVTDETGETVRYAGEPSGPGRFRPWLTASGERYDSHDVHPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ23</accession>
    <name>A0A0F4JJ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947654.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene721"/>
    <dbReference type="EnsemblBacteria" id="KJY33814">
        <property type="protein sequence ID" value="KJY33814"/>
        <property type="gene ID" value="VR44_13180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6854"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="51161" checksum="546FF3030BD745E2" modified="2015-06-24" version="1">MTTELRRLRNYIGGEFKDAADGRTTEVVNPATGEVYATAPLSGQADVDAAMAAAAAAFPGWRDTTPSERQKALLKIADAFEARAEELVAAESENTGKPLGLTASEELPPMVDQIRFFAGAARLLEGRSAGEYMDGMTSIIRREPVGVCAQVAPWNYPMMMAVWKFAPAIAAGNTVVLKPSDTTPASTVLMAEIIDSILPKGVFNVVCGDRETGKAMVEHSTPAMASITGSVRAGMQVAESASKDVKRVHLELGGKAPVVVFEDADLAKAVEDIAVAGYFNAGQDCTAATRVLVHESIHDEFVAALAKAAAETKTGQPDDEDVLYGPLNNPNQLAQVAGFIERLPAHAKVEAGGHRVGDKGFFYAPTVVSGLKQDDEIIQNEVFGPVITVQSFSDESQALEYANGVEFALASSVWTKDHGRAMRMSKNLDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSAYGFEDYTRIKHVMTSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ42</accession>
    <name>A0A0F4JJ42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_13230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947672.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33798">
        <property type="protein sequence ID" value="KJY33798"/>
        <property type="gene ID" value="VR44_13230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6865"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="33"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="20084" checksum="53CD458B300BEBF7" modified="2015-06-24" version="1">MDALIGQVSRGERVNFLPFWGHRPRPDGSLGPSCLSQWWPSPFTVGDVRYATAEHWMMAGKARLFGDPEAERAALEARTPAEAKKAGRLVRGFDDALWERERFALVVEGSVHKFGSDPALRAYLLGTGSRVLVEASPVDRVWGVGLAPDDERALDPARWRGLNLLGFALMEARTRLREEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJE5</accession>
    <name>A0A0F4JJE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000328">
        <property type="protein sequence ID" value="KJY33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947617.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000328.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2312"/>
    <dbReference type="EnsemblBacteria" id="KJY33913">
        <property type="protein sequence ID" value="KJY33913"/>
        <property type="gene ID" value="VR44_12980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6713"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="23766" checksum="B6D81C77E13B0BF5" modified="2015-06-24" version="1" fragment="single">MELSMLLDYAGDPRRAADEAAALESAGLDAVWVAEAWGFDSPTIMGYLAARTERMKIGSAIVNVYSRTPALIAQTAAGLDAMSGGRALLGLGASGPQVIEGWHGKPYDKPLGRTRETVELCRRIWRRETIDHHGITDMPLPPERGGRHGKPLKILTRPVRDRIPVYIASLGPANVALTAEIADGWLPTLFIPEKARAVWGSALAEGTAKRAAELGPLQTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJL0</accession>
    <name>A0A0F4JJL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947386.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3724"/>
    <dbReference type="EnsemblBacteria" id="KJY34517">
        <property type="protein sequence ID" value="KJY34517"/>
        <property type="gene ID" value="VR44_11755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6318"/>
    <dbReference type="eggNOG" id="COG3622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="29429" checksum="1E3C50C5E70A4183" modified="2015-06-24" version="1">MGYSDQRFDVNLSILFTELPLLERPAAAAAAGFTAVELWWPWIETPTPAQEELDALKKALEDAGTQLVGLNFYAGQLPGPDRGAVSVPGEESDRFNANINVAADFAASVGCKALNALYGNRVEGVDPAVQDELALKNLVVAAQAADRVGAILLIETLNKPESPLYPLVSAPAAIEIVDKVNEATGLGNAKFLLDLYHLAMNDEDLSEVIEKYAAKTGHVQIADKPGRGAPGTGELPLEDLLDQLKKAGYQGFVGLEYKAADAAASFDWLPAEARAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJW3</accession>
    <name>A0A0F4JJW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_12570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947552.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34104">
        <property type="protein sequence ID" value="KJY34104"/>
        <property type="gene ID" value="VR44_12570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6579"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="242"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="459" mass="49122" checksum="43E8299B9AC67467" modified="2015-06-24" version="1">MRRLRPATVRARATAGAVAVVAVALALASVALLGLLRSGMLRNAERDAEQQAVTIAQLAAGGRLDRMRAPVHGADFVQVVNARGRVLRATPNLAGLPALEPAGPQRPGTVFRTWRIRPLGGEHRQRVVRVTTQTPDGLVSVYVGTSLRDVDAADDTTTAALVVGGPLLLALVALVTWRVIGRALRPVEAIRAEVAEISDRDLHRRVPVPPTGDEVARLARTMNTTLDRLESSGIRQRQFIADASHELRSPLTVLRTQLEVALAVRDPELWPELISGALEDTDRLERLCSDLLLLARIDAAQPAASARLDLGGLVRDAVDARLGDRVPVRVRAEDGVVVEGSELWLTRVVTNLLDNAQRFAAAGVEVTLRASGPPDARTAVLEVRDDGPGIPPADRERVFERFTRLDDARSRDHGGAGLGLAIARDLAAHHRGTLTAEPSPTGARLVLRLPVIAPAAGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLD8</accession>
    <name>A0A0F4JLD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000275">
        <property type="protein sequence ID" value="KJY34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34634">
        <property type="protein sequence ID" value="KJY34634"/>
        <property type="gene ID" value="VR44_11590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6229"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8046" checksum="6BE66DD5DB1D5AF1" modified="2015-06-24" version="1">MGVRSDRDGPEPGPRPGHVYVESVGGPLAGELVDVCGWEPREIVDQAMLMWDHGRFGPASRPEEDLRHRLAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM63</accession>
    <name>A0A0F4JM63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000232">
        <property type="protein sequence ID" value="KJY35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35295">
        <property type="protein sequence ID" value="KJY35295"/>
        <property type="gene ID" value="VR44_10445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5831"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="20375" checksum="DEB9186F77C6AD02" modified="2015-06-24" version="1">MTRNVNTARRTDTRLHEASVVSTAAWVAAVAAVVFLWWVIGPEPWLFLAGGGAFILAAMVSSEAGKARKAFEAGMALLGEHPWQVWPCRLEVTGVTGRHRILLLAPDGSAARSYVARVPESVWYGMTDGIGALWVCGDLRFLVVMAQPGGTPLWIAHPEPASAASTAPADPTLIADLARTAGRAAVEDWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM81</accession>
    <name>A0A0F4JM81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000252">
        <property type="protein sequence ID" value="KJY34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947276.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000252.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34919">
        <property type="protein sequence ID" value="KJY34919"/>
        <property type="gene ID" value="VR44_11150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6114"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="21474" checksum="1DEAA1634F2D3BB9" modified="2015-06-24" version="1">MASRSTQILEAAARVIARRGVRGLRVEELAAEAGVSTALIYYHFKDRTGVLRQTLEFINDRAERYTTDRDPDAPPLTPREELDETLLLELQDTVEVRENSSAWGELRASAVFDEVLREDLARATLVWVQEVAALLGQVQPMATASSLAEAAERLTALLEGLSMRWLSGGIRIDHARELMRGAIEAELAGLQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMH9</accession>
    <name>A0A0F4JMH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947261.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34953">
        <property type="protein sequence ID" value="KJY34953"/>
        <property type="gene ID" value="VR44_11070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="17053" checksum="1920238D419B5633" modified="2015-06-24" version="1">MSESDDRPLLARRLDDLFKTVRPKGKHWTNAEVAEELKRVNPELKAGGVYLSQLRTGKRSNPSPDLLAALAKFFGVSVAYFFDDKVAESVLSQVAAIEALRQSGVRAVAMRAAGMKKENLAAITAIMDQYRQMQGLPPVTDAPVSDSAADGPGPSEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMN4</accession>
    <name>A0A0F4JMN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MDMPI_N domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000247">
        <property type="protein sequence ID" value="KJY35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947239.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000247.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35013">
        <property type="protein sequence ID" value="KJY35013"/>
        <property type="gene ID" value="VR44_10945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6072"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24480" checksum="38A55BB6A15755B4" modified="2015-06-24" version="1">METAPDTAADDTAAGARDPWLPDLLLRTERDVLIPLLRRTPEAAFGLRTACPGWTARDVLAHCAAALVRIVEGRLEEGVFLPAANAADVAERADWPVGRIVDELERGFSEAGPVIAAGDGRLDAVALGEWIHAGDVREAFGEPGAYAGNSLALALPLLQVTSRKRETPRLIADIDGHTGALELGNEVDGRPPARFSGDAATLIRLYSGRPLVATRYELAGATEGELLIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN42</accession>
    <name>A0A0F4JN42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947020.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35610">
        <property type="protein sequence ID" value="KJY35610"/>
        <property type="gene ID" value="VR44_09765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5453"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470718" evidence="2">
        <location>
            <begin position="30"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="3">
        <location>
            <begin position="311"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="529" mass="56239" checksum="49795C7F60F2187D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPF6</accession>
    <name>A0A0F4JPF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946818.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36060">
        <property type="protein sequence ID" value="KJY36060"/>
        <property type="gene ID" value="VR44_08685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4981"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17948" checksum="3F66C2EE07334C53" modified="2015-06-24" version="1">MNTKRVLIAYGTKHGATAGIAEQIGQTLREDGLDAVVLPAGDVDDVRDYDAVVIGGSLYAGHWSAKAKRCAERNADLLRHRPVWMFSSGPLDRSAEEKDIPPVAAVARQMQLVGAREHMTFGGSITAHTPGFLAKALLHEGKGGDYRNPERIRTWAHHISAELTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPX7</accession>
    <name>A0A0F4JPX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946748.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36250">
        <property type="protein sequence ID" value="KJY36250"/>
        <property type="gene ID" value="VR44_08350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4569"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="9002" checksum="B97DE8F325A7C40C" modified="2015-06-24" version="1">MAKPQTPDPITTLRAGLPDRYLTPDDIAELFDVPLETVYAWRKKRTGPPGFRVGKHVRYDPTAVHAWIADQMRADISQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ00</accession>
    <name>A0A0F4JQ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000161">
        <property type="protein sequence ID" value="KJY36432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946704.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000161.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36432">
        <property type="protein sequence ID" value="KJY36432"/>
        <property type="gene ID" value="VR44_08075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4442"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471247" evidence="2">
        <location>
            <begin position="30"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="209"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="544" mass="58674" checksum="F1A74CFC1771D087" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQP1</accession>
    <name>A0A0F4JQP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000157">
        <property type="protein sequence ID" value="KJY36495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36495">
        <property type="protein sequence ID" value="KJY36495"/>
        <property type="gene ID" value="VR44_07915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19154" checksum="435A0A5CC54818E7" modified="2015-06-24" version="1" fragment="single">MSDEEGGGSLYVLSAVLLTPTQFPALLGDDFPEACALLGVPPAAEGYGLVLGQDEDGARWTVVVDDVSLVAAAIASWDCGMEYDLSPDERTVVLSLAGWPLELTVATPGIPAPHDPERGADGTGRVPLAPPSADGWGPVQRRLGADQIAREWADWRERVAEDGGAAAAAHPGLARALREAVAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRE5</accession>
    <name>A0A0F4JRE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arabinose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000128">
        <property type="protein sequence ID" value="KJY36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36917">
        <property type="protein sequence ID" value="KJY36917"/>
        <property type="gene ID" value="VR44_06885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3461"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13625" checksum="AF2AF4F75560D4F2" modified="2015-06-24" version="1" fragment="single">VRLVFDAAPGPGVVVGLADLGDRFRLVANDVDVVAPPHPLPALPVARAVWRPRPDLRTSTESWLTAGGPHHTVLSTALTSDHLDDLAEMLRLELLLIDESTTPQRFRRELRWNQAYHRLALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSF8</accession>
    <name>A0A0F4JSF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspA</name>
        <name evidence="3" type="ORF">VR44_08980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946874.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2375"/>
    <dbReference type="EnsemblBacteria" id="KJY35886">
        <property type="protein sequence ID" value="KJY35886"/>
        <property type="gene ID" value="VR44_08980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4968"/>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="40753" checksum="8417B59789F85BBF" modified="2015-06-24" version="1" fragment="single">QEIRGGKLHDQFVVDVIQGGAGTSTNMNANEVIANRALELLGHARGEYGHLHPNEDVNLGQSTNDVYPTAVRIATVFAVRGLLDAMAVLQNAFTGKAAEFHDVLKMGRTQLQDAVPMTLGQEFSAFAVMLDEDRSRLAEALGLIHEINLGATAIGTGLNAPAGYAEAARRHLAGITGLPLVTAPDLVEATQDCGAFVQMSGVLKRIAVKLSKTCNDLRLLSSGPRAGLGEINLPPVQAGSSIMPGKVNPVIPEVVNQVAFEVIGNDITITMAAEAGQLQLNAFEPVILHSLSKSVTHLRAACLTLAERCVAGITANTEMLRATVENSIGLVTALNPHIGYTAATDIAKEALATGRGVAELVLERGLLPADRLAALLRPEVLAGTGPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSQ1</accession>
    <name>A0A0F4JSQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946382.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene57"/>
    <dbReference type="EnsemblBacteria" id="KJY37205">
        <property type="protein sequence ID" value="KJY37205"/>
        <property type="gene ID" value="VR44_06350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3024"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="243"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="35907" checksum="DF145A3C8313B457" modified="2015-06-24" version="1">MTMLDDRTTADTTWPTAYPQGYAVVDVETTGLARDDRIVSAAVYRLDAQGNVEDHWYSLVNPRRDPGPVWIHGLTSEMLSDAPLFEDIAGEFAERLADRVLVAHNAIFDWQMIAREYARASSAAPVRQRLCTIALSKELNLPLPNHKLESLAAHYGVVQQRAHHALDDARVLAEAFRPSLHAAARDGVRLPLLECRPLTEWSDSPATPRVGYQASYGGGGSWRASRKLPPSPYPNPGRFEDGKPLKQGMRVAFSGDTSVDRELLEDRAVEAGLHIATSVSRLTSLLVTNDPDSSTSKTVKARSFGTPVVDEAAFTQLLRDVAPAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUM1</accession>
    <name>A0A0F4JUM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000103">
        <property type="protein sequence ID" value="KJY37514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946234.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000103.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37514">
        <property type="protein sequence ID" value="KJY37514"/>
        <property type="gene ID" value="VR44_05550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1922"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471241" evidence="2">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="23995" checksum="6A8F784A42C4DD9B" modified="2015-06-24" version="1">MSRSPRPTAAAAPALAALAALAALAGCAAPGGLAAGEPVAPASPQPQPQALWPAWADDSPKSPGAATGTRQPPPAPLADAPEVGAGGLTAVKAADVVKADPRMRLFAEKGTINSPGRSGIRPPVYLDLTGDGQQELIVAADTETGRTALTVYAARGKRIVPVLFTLGRRMAAESLGQDLLIRTAPDDGSEQAVRYRWDGERMTVVNEERRYNKTLPAPSSGGSAPEADHGAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUV7</accession>
    <name>A0A0F4JUV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000138">
        <property type="protein sequence ID" value="KJY36771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36771">
        <property type="protein sequence ID" value="KJY36771"/>
        <property type="gene ID" value="VR44_07270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3795"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24834" checksum="D10BE313DD692EA7" modified="2015-06-24" version="1" fragment="single">MADAAHADDPAGQDAERTVHPVGAQLLWGDPDPLWAVGDWRPDEIRTVTADPADPFTRLAVLGCCGAGDEELRRALYAARGGALRHLTEWPGSYTAVVQAGRRITVLGDLAGARPVFYTPWAGGTAYATAALPLADLIGAQLDIGHLAALLACPDSPEALGDGTPYVGVRRIPPGHTLILREGSREITGYEPVASLAVAAPEADPEGAVEGVREALTAAVRARLTAPRHAPDTLLPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV46</accession>
    <name>A0A0F4JV46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">VR44_07065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946517.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36851">
        <property type="protein sequence ID" value="KJY36851"/>
        <property type="gene ID" value="VR44_07065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="33016" checksum="A8D935D6A6B4F2A0" modified="2015-06-24" version="1">MPGFVEKPEPVQVPGLVHLHTGKVRDLYRDEDGNLVMVASDRISAADWVLPTEIPEKGRILTQLSLWWFEQLADLVPNHVISTDLPAGAPADWEGRTLVCKSLDMVPVECVARGYLTGSGLKEYVQSRTVCGLALPEGLVDGSELPAPIFTPAAKAEVGDHDENVSYEEVARTTGAETAALLRQTTLAVYGRARDIARERGIILADTKFEFGFDKDGTLVAADEVLTPDSSRFWPADQWQPGRTQPSFDKQYVRDWLASPASGWDSKGELPPPVLPQEVVAQTRAKYVEAYERLTGQTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW60</accession>
    <name>A0A0F4JW60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946061.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37963">
        <property type="protein sequence ID" value="KJY37963"/>
        <property type="gene ID" value="VR44_04640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1009"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28769" checksum="C14615673AF2677C" modified="2015-06-24" version="1">MNAVAAATAQPTRATLTVDGRALSYLDFGGTGRPLVALHGHLSEGASFTALAAALGPEWRVIAPDQRGHGDSDRAPEYTRAGYLADLVALLDHLGIDRAVFLGHSLGAVNAYHLAAERPELVEALIDVDTAADLPDHGASPLAFVLDFPYTAPTREELAASCGPLAAVLGPVLRPLSDGSGWRLPFHPQDTVDSETLVHGDHWRQWLATDCPALLIHGLRSQVLPEEQARAMTARRPRTAYRALDTDHFVQQADPEGFAAAVREFLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWE6</accession>
    <name>A0A0F4JWE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_05945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946307.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37311">
        <property type="protein sequence ID" value="KJY37311"/>
        <property type="gene ID" value="VR44_05945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2403"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="34"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="488" mass="51427" checksum="B6F04729986EDF66" modified="2015-06-24" version="1">MSTTTTLQTAGGPTGEPGSAQPSDGLKAGLKNRHLSMIAIGGVIGAGLFVGSGGGIAKAGPAILISYLLVGAMVVFVMRMLGEMAAASPNSGSFSAYADRALGRWAGFSIGWLYWFFWVVVLAVEATAGAKILEGWVPAVPQWAWALIVMVVLTATNLGSVASYGEFEFWFAGIKVVAIGAFVVVGMLAVFGVLPGSDNPGAGFAHLTDAGGFMPNGWGSVLTGVLMVVFSFMGSEIVTLAAGESEDPRRAVTKATNSVIWRIGVFYLGSIFIVLTLLPWNDKSIVDKGSYVAALDSIGIAHAGQIMNVIVLTAVLSCLNSGLYTASRMAFSLGERGDAPKAFAKTSKNGVPTVAILGSVVFGFIAVYFNYTSPDTVFNFLLNSSGAIALFVWLVICLTQLRMRGILMREAPEKVTVKMWLFPYLTWATAAMITFVLGYMVYDKDNRETVLYSLLVAAVVIAIGVLRNARRKGELAAEAVADTVADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWK9</accession>
    <name>A0A0F4JWK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">VR44_05795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946277.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2545"/>
    <dbReference type="EnsemblBacteria" id="KJY37371">
        <property type="protein sequence ID" value="KJY37371"/>
        <property type="gene ID" value="VR44_05795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1974"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="379" mass="40350" checksum="AEDD645C66CF2FE6" modified="2015-06-24" version="1">MATDYYAVLGVRRDASQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQVYDLGGDPLSSSGGGGGAGGFGAGGFGNFSDIMDAFFGQASQRGPRSRTRRGQDAMIRLDLELDEAAFGTTKDIQVDTAVVCGTCSGEGAAPGTSAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRVRSRRSLTVKIPAGVENGTRIQLAGEGEVGPGGGPAGDLYVEIHELPHPTFQRRGDDLHCTVTIPMTAAALGTKCPLETLDGMEEIDVRPGTQSGQAIPLHGRGVTHLRGGGRGDLIVHVEVTTPGKLDAQQEELLRQLAKLRGEERPMGQFAPGQQGLFSRLKDAFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX61</accession>
    <name>A0A0F4JX61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_03010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945769.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4909"/>
    <dbReference type="EnsemblBacteria" id="KJY38740">
        <property type="protein sequence ID" value="KJY38740"/>
        <property type="gene ID" value="VR44_03010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7334"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="150"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="493"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="915" mass="101501" checksum="620FFAE63FF157FE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX98</accession>
    <name>A0A0F4JX98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37606">
        <property type="protein sequence ID" value="KJY37606"/>
        <property type="gene ID" value="VR44_05380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1712"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="26995" checksum="215DE6773AF24494" modified="2015-06-24" version="1">MMRILVVLTAKATLHLLDGEQHPSGFWAEEFVVPYTLFQAAGHTVDVATIGGATPTVDQTSIDPQFLQYVRPAGSPDEDAANAAEYVRVIEQAPQLRSPLAIESLGEKDVAGYDALYISGGHGAIGDLPKSDELAQVLRWAIAQDKPIATVCHGHTSLLALRDGEGRWPFEGYRMTAFSHEEELVTNMAGRLPLILEAELTRLGARYEKADAIWDSHVVVDRKLTTGQNPYSSKALAETFLRQLDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY64</accession>
    <name>A0A0F4JY64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000050">
        <property type="protein sequence ID" value="KJY38789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38789">
        <property type="protein sequence ID" value="KJY38789"/>
        <property type="gene ID" value="VR44_02840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7295"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="40089" checksum="0475623DF035D318" modified="2015-06-24" version="1">MHTASGVTTPLTVGVEEEFLLVDDRTLRVVPAAPRVLATAAGLPQQLHPEGTRYQVEISTPVADSAITLREELAALRRTLAAAAREHGCRLLAAPSPVVAVEGPLHLTDDEPRQREQHRRFGALTDTLVSCGRHIHIGTLDVDTAVAVSNRVRPWLPTLIALAANSPFWGGRDTGHSSWRAMAWSGWPSAGPPPHFPSTAHFRRSVQTLLGSGAALDTKMVYWDLRPSGNWPTLEIRAPDMSPDIDTAVLQAELGRALVSSALRQIAEQRPDPPVRDDVLRLARWRAAHDGLEGFGLDPYTGAELPAADLAEALLDLVAPDLAAAGDLDHAANTLGGLLRDGSGAARQRAAFARRQDLTDVLRHLVEETEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYV5</accession>
    <name>A0A0F4JYV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945560.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39330">
        <property type="protein sequence ID" value="KJY39330"/>
        <property type="gene ID" value="VR44_01890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5782"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26221" checksum="8F027EAC37D3A473" modified="2015-06-24" version="1">MAENTSRVAVVTGGSRGIGRAVVERLLADGYHVGYCFQTASDAAADIERLAEEHGVRVSATRVDVTDEAAVRAYLRQTEDTLGPIDVLVSNAGVIRDAPLLRMQAEDWNTVIETNLTGTYNVCRAAIFEFMKRGTGSIVTISSVTGVYGNAAQTNYAASKAGIIGFTKSLAKEVGRFGVRANVVAPGFIATDMTDSVSEAVRDRTVKKIPVGRLGTAQEVAEAVAFLASPRSSYITGHVLHVDGGIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZF2</accession>
    <name>A0A0F4JZF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39209">
        <property type="protein sequence ID" value="KJY39209"/>
        <property type="gene ID" value="VR44_01955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5797"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="30366" checksum="564AB058983383E7" modified="2015-06-24" version="1">MQFQILGPLEIETRDGQRVSPRALKLRSLLAYLCMHSTRPVSMDRLIEALWSGTPPQSATTALHVYVSQLRKYLSSVGVDPKLIVTQPPGYRLDLCSQTLDLRRFESLLCHFRSLHAQDRLEEAAEAINAALALWRGPALEDLRAVPFFHNLCRQLNEKRAFAYEQKFEIELKLGRHNSLIGELYSLIDEQPTRENLYWHLMIALYRSGRIAESLAEYGRIRKILVQDLGVEPGLKLQKLHRAILAREAWLDDSWEDVRSAYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0E5</accession>
    <name>A0A0F4K0E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945751.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38721">
        <property type="protein sequence ID" value="KJY38721"/>
        <property type="gene ID" value="VR44_02880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="36362" checksum="8D899CCD07E1DDF4" modified="2015-06-24" version="1">MSQIPAVSREWHLVRRPQGWPVAEDFALREVPVSAEPGEGRILVRNLHMSVDPYMRGRMNDTKSYIPPFQLDEPMQGGAVGEVVASNAEGFEVGDHVLHMLGWREYAELDAKHATKVDGSLAPLSAYLGVLGMPGLTAYAGLFEVASFKEGDSVFVSGAAGAVGSLVGQFAKIKGASRVIGSAGSDEKVTLLTEKYGFDAAFNYKNGPVAQQLKEAAPDGIDVYFDNVGGDHLEAAISEMNPHGRATLCGAIAGYNETEPAPGPRNLTLVIGKRLRLQGILVGDHAALQSQFVKDVAGWLASGELRYDETVVEGVENATDAFLGMLRGENTGKMIVTFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0S1</accession>
    <name>A0A0F4K0S1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="12" type="ORF">VR44_00820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945368.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4780"/>
    <dbReference type="EnsemblBacteria" id="KJY39714">
        <property type="protein sequence ID" value="KJY39714"/>
        <property type="gene ID" value="VR44_00820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2869"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="11">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="542"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="870" mass="95834" checksum="B7B12CD720148661" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0X5</accession>
    <name>A0A0F4K0X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945427.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39578">
        <property type="protein sequence ID" value="KJY39578"/>
        <property type="gene ID" value="VR44_01135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2941"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="30081" checksum="4040C9B193FBAA0C" modified="2015-06-24" version="1">MTSAPQRPDGPFPAPRLIATDLDGTLLRDDKSVSLRTVAALAAAEEAGIEVFFVTGRPARWMDVVSEHVHGHGLAICANGAAVVDLHAGREFVQVRALPRATALTVVETLRGAVPGTSFAVETTTGINYEPAYPPFFQDPGATVATAEKLLRQESDDSAPPVLKLLAHHAELAPDEFLALARSAAGAYAAITRSSPTALLEISELGVSKASTLELCCAERGISPAEVVAFGDMPNDVEMLRWAGTSYAMGNAHPDVIAAASGRTVDNNEDGVAVVIERILAERAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K449</accession>
    <name>A0A0F4K449_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="9" type="ORF">VR44_00275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945285.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1023"/>
    <dbReference type="EnsemblBacteria" id="KJY39931">
        <property type="protein sequence ID" value="KJY39931"/>
        <property type="gene ID" value="VR44_00275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.53"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22731" checksum="FCBCEEA42377838B" modified="2015-06-24" version="1">MAKQIKGVLGEKLGMTQVWDENNRVVPVTVVKAGPCVVTQVRTNDIDGYESVQIAFGEIDPRKVNKPLKGHFAKADVTPRRHLVELRTSDASEYTLGQEITAAVFESGVKVDVTGNSKGKGFAGVMKRHNFRGLGAGHGVQRKHRSPGSIGGCATPGRVFKGMRMAGRMGNERVTTQNLTIHAVDAEKGLLLIKGAVPGPNGGLVLVRTAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7K7</accession>
    <name>A0A0F4I7K7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF642 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001633">
        <property type="protein sequence ID" value="KJY18000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952569.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18000">
        <property type="protein sequence ID" value="KJY18000"/>
        <property type="gene ID" value="VR44_39755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6133"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006946">
        <property type="entry name" value="DUF642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04862">
        <property type="entry name" value="DUF642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469486" description="DUF642 domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF642" evidence="2">
        <location>
            <begin position="72"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23358" checksum="3623FD252B9CAEB5" modified="2015-06-24" version="1">MANTTRSRAAARTALVVSLATMLAGTAATSASAASVVPVTNPAFIQPYVNPDNASEFVRVTLGSNAIHGWRLGSNAIPGWRVVLGSVDVFGRATSRTPDGSQAVDLGGSERGGIEQTIATEEDAEEQVTFKAKINDHPDCVSGARDIAQEFHVQFAADPEHAQRFELGSIAKPARGSSTWTLRRATLWGTDRFSRLQFISDTNHACGPLITDVKVIERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8Q4</accession>
    <name>A0A0F4I8Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001694">
        <property type="protein sequence ID" value="KJY17066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17066">
        <property type="protein sequence ID" value="KJY17066"/>
        <property type="gene ID" value="VR44_40160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6324" checksum="E450BA6143A63073" modified="2015-06-24" version="1" fragment="single">MADGPWGAAVRLLWGPPVTPARGPRRGLTLEQIAAAGVGIADAEGLGGVSMQAVAGELGVTKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ID84</accession>
    <name>A0A0F4ID84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_39120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001552">
        <property type="protein sequence ID" value="KJY19418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952449.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001552.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4157"/>
    <dbReference type="EnsemblBacteria" id="KJY19418">
        <property type="protein sequence ID" value="KJY19418"/>
        <property type="gene ID" value="VR44_39120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5587"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY19418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="33181" checksum="02AD9991FE23CDEF" modified="2015-06-24" version="1">MTTVTSTTVTRLGGRIGAEIGGVRLGGDLDAAAVAEIRAALLAHKVVFFRGQEHLDEAGHEAFARLLGTPVAHPTVPSADGRYALGIDSHHGARANQWHTDVTFVPAYPAFSILRAVTIPPYGGNTLWANTATAYAHLPAPLRALADGLRAVHSNEYDYAALKPDALPEALAQYREVFTSTTFLTEHPVVRVHPETGERTLLLGNFVQRIAGLTGRDSRALVDLFQAHIESPENTVRWQWRAGDVAIWDNRATQHYGVDDSDDHERTLRRVTVDGDVPVGPDGVPSRLISPDTVPDPAFGIASGASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKQ5</accession>
    <name>A0A0F4IKQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001416">
        <property type="protein sequence ID" value="KJY22577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952218.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001416.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1421"/>
    <dbReference type="EnsemblBacteria" id="KJY22577">
        <property type="protein sequence ID" value="KJY22577"/>
        <property type="gene ID" value="VR44_37875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5135"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY22577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="37607" checksum="B7261E6FC4562147" modified="2015-06-24" version="1">MTHRVRGVIARSKGAPVETTTILVPDPGPGEALVKVQACGVCHTDLHYREGGINDEFPFLLGHEAAGVVESVGPDVTSVAPGDFVVLNWRAVCGTCRACKRGRPWYCFATHNATQPMTLEDGTPLSPALGIGAFAEKTLVAAGQCTKVDPAASPAAAGLLGCGVMAGLGAALNTGNVGRGDSVAVIGCGGVGNAAVAGARLAGASKIIAVDLDDRKLEWARGLGATHTVNGRAQDVVKAIQELTGGNGADVVIEAVGRPETYQQAFYARDLAGTVVLVGVPTPEMKLELPFLDVFGRGGALKSSWYGDCLPERDFPLLIDLYLQGRLDLDAFVSETIPLDGVEEAFARMERGEVLRSVVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM46</accession>
    <name>A0A0F4IM46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001418">
        <property type="protein sequence ID" value="KJY22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952220.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001418.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22553">
        <property type="protein sequence ID" value="KJY22553"/>
        <property type="gene ID" value="VR44_37895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5139"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="19843" checksum="495380BC107BC38E" modified="2015-06-24" version="1">MPETLLEQHAAALRLFGERVRAVADGQWGAPTPCTEWTVRDLVNHVTGEQLWTVPLVTEGRTVAEVGDALSGDLLGGDPAGAWERAAAAARAAFAAPGALERTVVLSYGPTRAAAYCAELTADCVVHAWDLSRGIGADDRLPDGLVEFSLKEVMPYADGLAASGLFAAPLEVPAGADAQTRLLALLGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IMJ5</accession>
    <name>A0A0F4IMJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001440">
        <property type="protein sequence ID" value="KJY21846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21846">
        <property type="protein sequence ID" value="KJY21846"/>
        <property type="gene ID" value="VR44_38145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12932" checksum="55A9A7B42BD890EC" modified="2015-06-24" version="1" fragment="single">MSGERVQHTSYSVDVAAPAGVVYALLADTTQWPLFVPPSIHVERLDFDGTHDRFGMWATAGGTVTSWVSRRSLDPARRTIDFHQEVPAPPATALSGRWEVAELAGGRSRLTLHHLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQF1</accession>
    <name>A0A0F4IQF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001336">
        <property type="protein sequence ID" value="KJY23899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952043.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001336.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23899">
        <property type="protein sequence ID" value="KJY23899"/>
        <property type="gene ID" value="VR44_36925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4701"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469736" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="328" mass="33957" checksum="E5119BFC08BA12C0" modified="2015-06-24" version="1">MGNPLGKEHRLPLLLACLVLALGLIAAVLGASRAAGPASVVGPHVDMRRVPPGAAGPAPGPGASTGTVTVECGRNEEGHWNEDNLVVSPGVRAGAHHTHAYVGNLSADALSTDASLAAATTSCTGGDRSVYYWPVLRRTDRAGSGPHEGAAGHGNAGEILREASVRVEFRGSPVSGVVAMPRFLRAITGDAVAYTAGGGAGVRARWGCSGLPDRSTTGYPRCPAGELVTRTLVFPSCWNGLDTASPDHRSHLLFPSASGVCPQGTFPVPELRLSLAYAVAPGVPLALDSFPEQRHSPLTDHAMFVDVMTDARMGELVSCLNEGRHCRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQS8</accession>
    <name>A0A0F4IQS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001242">
        <property type="protein sequence ID" value="KJY24357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951790.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001242.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24357">
        <property type="protein sequence ID" value="KJY24357"/>
        <property type="gene ID" value="VR44_35605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4241"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="34073" checksum="EE3CBEAB3FA5534F" modified="2015-06-24" version="1" fragment="single">LEGGASAIAFASGMGAISGVLLALLRPGDQVIAQRCLYGGTYAALSDLAERYGVRVDYIGGDDAGEFEALAGPRTRLLVLETIANPTGQVPDLPGLLAAARRLGVLSAVDNSLASPVLCRPIEHGADIVLHSTTKYLAGHSDVLGGAAVFADDALRREVWPRTVELGASADPFAVWLTLRGIATLPLRMREHCANAGLLAQRLADHPAVAAVHWPWLRTHPSYALARKVLSGGGGLLSFELHGGREAGRAFVEGVRLARLALSLGGVETLVTHPASTSHRELDEGALARAGIGPGLVRMSVGIEDPEDLWQDAEQALRSSFGLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR57</accession>
    <name>A0A0F4IR57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001216">
        <property type="protein sequence ID" value="KJY24505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951711.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001216.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24505">
        <property type="protein sequence ID" value="KJY24505"/>
        <property type="gene ID" value="VR44_35165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4112"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="42108" checksum="F28872071FC65ABC" modified="2015-06-24" version="1" fragment="single">RVPAAGRAKAAPRLSEAARAADGQVTKTVDNGPTADRLDVVFVGDGYTAAELDRFHADVRAKWAEVTAVEPYTTYRDLFNVWTVDAVSAQSGVSGDPGPDTVRDTALGSYFWCGSIERLLCVDQPKVDAYVAKAPAADLVIVLANSAKYGGAGYNEPSPTLGYEGISTASAGHPKSGQVAIHETGHSLGKLADEYFYPGVPDYERYTGPEPADPNTSTLDASAMAAQRAKWYRWLGETSPDGGTVGAYEGGGYYVTGLYRPTDNSIMRVLGKPFNLPGVEAMIAGFRRHARLVTPLTPTDRPLRLWRTAQVAVPHLASADGRQPVVRWYLDGRELGRFAGRTEVRVAELWLLDLRTHKLSVTAEDRTPAVRDPEIARSLSSTVTWDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRY3</accession>
    <name>A0A0F4IRY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001172">
        <property type="protein sequence ID" value="KJY24762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene855"/>
    <dbReference type="EnsemblBacteria" id="KJY24762">
        <property type="protein sequence ID" value="KJY24762"/>
        <property type="gene ID" value="VR44_34375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3853"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="24996" checksum="40F96BF5E7EA6F9B" modified="2015-06-24" version="1">MLVVEDDQFVRSALIRHLTEASHTVRSVGTALEALREVAHHRFDVVILDLGLPDLDGSEALKMLRGITDVPVIIATARDDEAEIVRLLNDGADDYLTKPFSVEHLSARMAAVLRRSQATAAEPPPRVLRVGGLAIDPLRRQAELDGAVLDLTRREFDLLTFLAGRPGVVVARRELLAEVWQQSYGDDQTIDVHLSWLRRKLGETAARPRYIHTLRGVGVKLEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS42</accession>
    <name>A0A0F4IS42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="19" type="ORF">VR44_37610</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001392">
        <property type="protein sequence ID" value="KJY23491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952165.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001392.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5327"/>
    <dbReference type="EnsemblBacteria" id="KJY23491">
        <property type="protein sequence ID" value="KJY23491"/>
        <property type="gene ID" value="VR44_37610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5027"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="438"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="674"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="670"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJY23491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="719" mass="80620" checksum="F770957174EA69FD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISB0</accession>
    <name>A0A0F4ISB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001212">
        <property type="protein sequence ID" value="KJY24529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951700.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001212.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24529">
        <property type="protein sequence ID" value="KJY24529"/>
        <property type="gene ID" value="VR44_35100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4097"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6669" checksum="D4C61E3776A9C33A" modified="2015-06-24" version="1">MRVGVDRRLCCGAGMCALLAPEVFDQCDEGFVVLLDPAPPAAAHAAVREAADQCPCSAITLHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISJ1</accession>
    <name>A0A0F4ISJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001142">
        <property type="protein sequence ID" value="KJY24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951464.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001142.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24957">
        <property type="protein sequence ID" value="KJY24957"/>
        <property type="gene ID" value="VR44_33825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3690"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23494" checksum="15D015E4A8B34259" modified="2015-06-24" version="1">MSRPPLRVVIADDERMVRTALRVILDAEAGLEVVGEAATGAEAVSLVRSLAPDVVLMDVRMPEIDGIRATEQILATMPDPPRIVVVTTFENDDYVYDALRAGASGFLLKRADPDELIGAVRLVARGDSLLFPAAVRSLAAAHAAAAPPAPPAWAARLTDREADVLRLMATGLSNHEMSEHLGVGPQTVKTHVAAVLAKTGSRDRTQAVIAAYEGGFLMKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISM6</accession>
    <name>A0A0F4ISM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001134">
        <property type="protein sequence ID" value="KJY25010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951441.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001134.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25010">
        <property type="protein sequence ID" value="KJY25010"/>
        <property type="gene ID" value="VR44_33700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3650"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19810" checksum="3886DBB95FF154F9" modified="2015-06-24" version="1">MPARPTLVVVSGPPATGKTTLAHTLARQLGCPVIVRDEIKQGMVMNATAHRTGRDDPLNVPAMHAFFDTLGLLVRAGVTVVAEAAYQDRIWRPGLEPLTTLADLRILRCTAPTPTITERMTHRADSDVHRAAHDDRRLLTDLSTGAYNPQAFADISLAAPTLLVDTSDGYRPGTAEIAAFARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISS0</accession>
    <name>A0A0F4ISS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001127">
        <property type="protein sequence ID" value="KJY25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951423.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001127.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5674"/>
    <dbReference type="EnsemblBacteria" id="KJY25055">
        <property type="protein sequence ID" value="KJY25055"/>
        <property type="gene ID" value="VR44_33580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3598"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="364" mass="39102" checksum="48133B8E21833205" modified="2015-06-24" version="1">MAAVSDRLPTFPWDKLEPYKKTAAAHEDGLVDLSVGTPVDPVPQLIQDALIGAADSPGYPTVWGTPQLRDAITGWLRDRLGASAAGHRNVLPVVGSKELVAWLPTQLGLGAGDKVAYPRLAYPTYEVGARLCGAEAVVYDDPTELDPAGLKLLWLNSPSNPTGKVLGKEELIRIVAWAREHGILVFSDECYLELGWEADPVSVLHDDVCGGSYEGLVAVHSLSKRSNLAGYRAAFIAGDENVLAELLEIRKHGGMMTPAPVQAAVVAALGDDAHVAEQRGRYAARREALRTALEAHGFRVEHSEASLYLWVTRDEPCWDTVAHLASLGILVAPGDFYGEAGANFVRVAFTATDERVEAAVKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISU7</accession>
    <name>A0A0F4ISU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminohydroxyphosphoribosylaminopyrimidine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001176">
        <property type="protein sequence ID" value="KJY24729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951581.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001176.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24729">
        <property type="protein sequence ID" value="KJY24729"/>
        <property type="gene ID" value="VR44_34470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3875"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="2">
        <location>
            <begin position="43"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="27152" checksum="4F79CE29242C48FF" modified="2015-06-24" version="1">MRRLFPVTDQTSSPSGATADREWSLDELAEAYAYPELAPGAHWLRANMVSTLDGAAQHDGRSQPISGETDMRIFGTLRALADVVIAGAETVRQEGYRPARAREAFAARRAAAGQGPAPAIAVVTASLDLDFTLPLFTSPLVPTLVLTGAGAPSDRVAEATAAGAEVVVAGEGAAVDPARAVRELAARGLRRQLTEGGPRLLGQFVAADALDELCLTISPMVTAGDAQRIAGGPSVTVPHRLVPASVLEEAGFLFTSYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX7</accession>
    <name>A0A0F4ISX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBP-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001204">
        <property type="protein sequence ID" value="KJY24563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951677.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24563">
        <property type="protein sequence ID" value="KJY24563"/>
        <property type="gene ID" value="VR44_34985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4046"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12534" checksum="C32774F64B16E9F7" modified="2015-06-24" version="1">MTEIDGIDPGVPPSGTGCGDCDAVGGWWFHLRRCAQCGHVGCCDSSPAQHATAHWKSAGHPLVQSFEPGESWFWDYATGTMYESGPDLTPPDAHPADQPAPGPAGRVPQDWPSRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISY3</accession>
    <name>A0A0F4ISY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25115">
        <property type="protein sequence ID" value="KJY25115"/>
        <property type="gene ID" value="VR44_33340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3545"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="45068" checksum="24178ADE63E83F64" modified="2015-06-24" version="1" fragment="single">GGSPVPIGPGPRATASAPAGLAAADSATGWVRPPAGVRAQAAAPVATPSVPAPGPSPDSGRWRPWRFRMSNEVWGTPAVAGDLLYVTSFEVHALDVGSGRRQFKTRDVAWSMAVADGRIHASDGPSLFALDAKDGSERWRLNADAWVYALRAERGTVITVTRGGGVQGWEASNGQKLWELTGAQTDFETPEAAPVLHDGTVYVWQDARLRALDARSGLEAWSYPVGDAASCGNVPVRVTPAPDGNVYVAAGTRVLSVDRASGRVRWHFEAPAVFLAPPAFAPGPAVTGGGVYLADYLGTVYALDAATGKDRWRIATEPRPAADPVLVAGGNVHLGAGSALYTLDAVTGTPKWRFAAGGEITGPPVVADGRVHFGSADHCLYTLDAAGGQLRWKLATGGEITGAPVVEAGVVYACSKDRCVYALDAAKGTGTRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITF2</accession>
    <name>A0A0F4ITF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001095">
        <property type="protein sequence ID" value="KJY25300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951285.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25300">
        <property type="protein sequence ID" value="KJY25300"/>
        <property type="gene ID" value="VR44_32860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3390"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470239" evidence="1">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21311" checksum="3A571FF7675D1C14" modified="2015-06-24" version="1">MHRTTLRLAVPLALAAALTATAGLPALAADAPSPSPASAAPGAGAGGPGGISGITGWARMAYGDPRDDVQISVDAHGLFAPAGSTTATHPRGRFRIQHYSPAKDGQPANFNWGDFTVDCLRVDGTEVSVTGRIVDAGPVWQTFLDRKPLPARMGLSFHLPAPGGRPDEALVGITPPAAEGTPDIPKCSTAPAESALTAGGYVLATRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUI3</accession>
    <name>A0A0F4IUI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001037">
        <property type="protein sequence ID" value="KJY25675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25675">
        <property type="protein sequence ID" value="KJY25675"/>
        <property type="gene ID" value="VR44_31875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10468" checksum="5F1359EB9AF0DD7C" modified="2015-06-24" version="1" fragment="single">MREEVRTADGRVLTAEHWGDPDGKPVFLLHGMPGSRLGPAPRGMVLYQRRVRLIAYDRPGYGGSDRHPGRTVADVAQDVAAVADALGVDTFAVAGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUR9</accession>
    <name>A0A0F4IUR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001028">
        <property type="protein sequence ID" value="KJY25757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951070.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25757">
        <property type="protein sequence ID" value="KJY25757"/>
        <property type="gene ID" value="VR44_31685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3046"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="30663" checksum="84A7792D8E39DEB1" modified="2015-06-24" version="1" fragment="single">MRPVHTALAVLVAAVWGFNFVVIQIGLGHFPPLLLSALRFLVAALPAVFFVGRPKVAWKWVVGVGVALGIAKFGLLFTGMAAGMPAGLSSLVLQIQAVFTAVLAAAVLRERPGPVRVLGMAVALAGIAVAAADTGLSGPATGFTLVVAAAACWGVSNVLTRKAAPPDALNFMVWVCTVPVLPLLGLSLLLEGPGRDLAALRALDWSGVAVIGYVAWVSTVFGFGAWGYLLRRYPASAVAPFSLLVPVFGMSSAALVLGEPVSGLRWLAAVLLVGGVGLTSLAPAGGRRGAAAAAGAADRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV95</accession>
    <name>A0A0F4IV95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001057">
        <property type="protein sequence ID" value="KJY25559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951161.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25559">
        <property type="protein sequence ID" value="KJY25559"/>
        <property type="gene ID" value="VR44_32170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3154"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="13640" checksum="4C9A759EF3BB838D" modified="2015-06-24" version="1">MSQHAIAYIHSQNISDGTARRVFLAIAEQSRGEGDILGLNLWDADIPVLARRIGLDADEFRRQLRTLKQHVRMDVLEHSDGLWEIVYGPSYTKPPRPRPQPVTPDALRAGPQAFWMPGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVI0</accession>
    <name>A0A0F4IVI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001041">
        <property type="protein sequence ID" value="KJY25649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951118.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25649">
        <property type="protein sequence ID" value="KJY25649"/>
        <property type="gene ID" value="VR44_31940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3103"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29026" checksum="093E0F6CACB2A58D" modified="2015-06-24" version="1">MSDDEATTAWRRWHEQRVATVSAPYGPLALTGTHWLSESVPEDLEGRIPAVPGRWRAGADGVLVSACAEDGLELDGKPLDGEALLAADAGRPADSRLAAGEVRLVVIRREGEWAVRTYDPGSAARRAFRGIEATPYDPAFALPGRFRPYGEDRTVQVENADGRARGLGLGGELLFEYGGARHALHVAVDADDGSLWAVFADATSGDSSYRFRFLRPGTPGPDGGITVDLNRALLPPCAFADHFICPFPPPGNTLPFAAAAGERRLKGALVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVV2</accession>
    <name>A0A0F4IVV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001052">
        <property type="protein sequence ID" value="KJY25583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951149.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25583">
        <property type="protein sequence ID" value="KJY25583"/>
        <property type="gene ID" value="VR44_32105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="79"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="21430" checksum="8B645C35A829F27E" modified="2015-06-24" version="1" fragment="single">PEALFTGQRQNRRTALDPYKPYLHDRWQDGCTNAWQLWEELKEQGYSHGYASVRDYIRSVLRGRPQPIGPRPPTARTVTRWILTHPDALQESDRIQLKTVLAACPELDVLASHVRSFARMLTQLEGHRMPEWIEVASTADLPALQSFARHLERDLDAVIAGLSLPWNSGVVDGHVNRIKMLKRQMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWV5</accession>
    <name>A0A0F4IWV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_33230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001113">
        <property type="protein sequence ID" value="KJY25166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951355.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001113.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25166">
        <property type="protein sequence ID" value="KJY25166"/>
        <property type="gene ID" value="VR44_33230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3521"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="441" mass="45193" checksum="DD0E8462CB50916E" modified="2015-06-24" version="1">MARLALASLVGTAIEFYDFFAYGTAAALVLGPLFFPSFSPLAGTLAAFGTFGVGFIARPLGSVVFGHIGDRYGRRPVLLASLLLTGLATVAVGCVPSYASIGIAAPVLLLLLRFLQGLGLGGEWGGAVLLTAEHAPEGRRGLWSSFPQMGPSAGFLMANGLTLALSGLLSDARFTAWGWRVPFWCAGLLALAGLWLRRSVEETPEFRALSATGRRAQAPLPEVLRGHWRLLLLTGGAMSVGYAVFYAVTTWSLAYTTGPLHMDRTVMLAVVMAAVLLMGLVTAPLAALGDRWGRRPLCLAGSAACVLWMFPFVALLGSADPLLVTVGCTGCTGALLAMVVMYAVAGAYLPELYAPRIRCTGAAVGYNLGGVLGGALTPVVATALAAGSGPPWGVAVFLTVVALVSLGCFALLPETRPVPAAARGGTGADTGAGAAEAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWW2</accession>
    <name>A0A0F4IWW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_29810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000928">
        <property type="protein sequence ID" value="KJY26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950727.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000928.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26535">
        <property type="protein sequence ID" value="KJY26535"/>
        <property type="gene ID" value="VR44_29810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2342"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="224"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="421"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="628" mass="66859" checksum="344F9A5C274CDF3A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXH5</accession>
    <name>A0A0F4IXH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000907">
        <property type="protein sequence ID" value="KJY26740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene187"/>
    <dbReference type="EnsemblBacteria" id="KJY26740">
        <property type="protein sequence ID" value="KJY26740"/>
        <property type="gene ID" value="VR44_29285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2208"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="24782" checksum="83ADE8AEB76B7097" modified="2015-06-24" version="1">MAGGQGSRLRPYTDDRPKPMVEIPGTGLPIIGHQLAWLAAEGVTDVVVSCGHLAGVLQEWLAGAVLPLRVTTVVEEEPLGRGGGLKYAARHLPHPDRAWYAANGDVWTRFPLREMAAFHAERAAVATLALARPRIPWGVVETNEFGQVLDFVEAPPSPYPVNAGVYVFAPEFAALLPDLGDHERTTFPRLARERRLAGFPLPQGAYWRAIDTAKDLAEAARELAAQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXS8</accession>
    <name>A0A0F4IXS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000900">
        <property type="protein sequence ID" value="KJY26822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000900.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26822">
        <property type="protein sequence ID" value="KJY26822"/>
        <property type="gene ID" value="VR44_29125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2166"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14521" checksum="51E8AF9063270F4D" modified="2015-06-24" version="1">MSSEPILLSKALASFDALWSPRIVTRVNDYDVRIAKVEGEHIWHAHDDTDEFFLVLDGELHISLREPDGERTVLLPQGAVFTVPRGTEHKPHAPSGAAILMFEPTGTPTVGDRHDEVPDHVDSTIGHALDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXU3</accession>
    <name>A0A0F4IXU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000898">
        <property type="protein sequence ID" value="KJY26837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26837">
        <property type="protein sequence ID" value="KJY26837"/>
        <property type="gene ID" value="VR44_29090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="9601" checksum="1E5FE2A341B7D0C1" modified="2015-06-24" version="1" fragment="single">MARLRVPRRIGRPRVTPDAVLADKAYSSRAIRRHLRRRGIRAVIPQPADQTANRKRLGSRGGRPPAFDRETYKQRNTVERCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXX3</accession>
    <name>A0A0F4IXX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000891">
        <property type="protein sequence ID" value="KJY26895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26895">
        <property type="protein sequence ID" value="KJY26895"/>
        <property type="gene ID" value="VR44_28955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2090"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="105"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="22151" checksum="F9DE7CF46E0A1FA4" modified="2015-06-24" version="1">MPADAPDARALAVCGPPVPGVRIEIRQEDGTPLEERRVGEIWVNSPSLMQGYWEDPEATATVLRDGWLRTGDLGYRTEDGGLVVCGRVKDMIIVSGRNLYPEDYEHVAAKVEGVRPVCAAFAVPDTERMIVAFETAKGFENHAELAALVMKRLREHLGHAPDKVVALDKGAIPRTSSGKVQRALTRERYLTGKLPVLAELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYF0</accession>
    <name>A0A0F4IYF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoacyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950495.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27027">
        <property type="protein sequence ID" value="KJY27027"/>
        <property type="gene ID" value="VR44_28545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2038"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="27930" checksum="5454CEBF2C29F91F" modified="2015-06-24" version="1">MPDQAQEQDQTKRVAVVTGATSGIGLEAARTLAAQGHRVFIGARDADNVARTVKELTAEGLEVDGASVDVRSGEDVKAWVEAAVERFGTIDVVVNNAGRSGGGVTADITDELWYDVIETNLNSVFRVTREVLNTGGMRAKNRGRIINIASTAGKQGVVLGAPYSASKHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAERVRQGYAAAYQTTEEAVLEKFQAKIPLGRYSTPQEVAGLVGYLASDTAASITSQALNVCGGLGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYY3</accession>
    <name>A0A0F4IYY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene545"/>
    <dbReference type="EnsemblBacteria" id="KJY26864">
        <property type="protein sequence ID" value="KJY26864"/>
        <property type="gene ID" value="VR44_29050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2143"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21986" checksum="C93B0084902A0F50" modified="2015-06-24" version="1">MTGAERRQQLLDIGRTLFAEKGFEGTSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDREMRQLLDGVTGALTAGHPRELLEQAAFALLDYIENYTDGFRILVRDSPVAQSTGTFASLISDIATQVEDILGLEFKARGFDPKLAPLYAQALVGMVALTGQWWLETRRPKKAEVAAHLVNLAWHGLENLEARPRLVGHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZH4</accession>
    <name>A0A0F4IZH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000876">
        <property type="protein sequence ID" value="KJY27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950492.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000876.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27044">
        <property type="protein sequence ID" value="KJY27044"/>
        <property type="gene ID" value="VR44_28530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="36260" checksum="E536510C676ECD18" modified="2015-06-24" version="1" fragment="single">MERPRILVVGAGFAGVECIRRLERRLAPAEADIALVTPNSYQLYLPLLPQVASGVLTPQSVALSLRRSSRHRTRIIPGRAVGVDTRAKVCVIRKITGELTDQPYDHLVLAPGSITRTFDIPGLTEHARGMKTLAEATHLRDHVISQLDLADASEDEAERAARLCFVVVGGGYAGTETAACLQRLTHHAVKRYPRLDHRHISWHLLDLAPRLMPELGDSLGRTALDVLRRRGIQVSLGVSVAKAGPTEVALTDGRVLPSRTLIWTAGVTASPLIGTLGAETVRGRLLVTPEMTVPGAPGVFALGDAAAVPDLAAGQEGALCPPTAQHALRQGRTLADNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0T6</accession>
    <name>A0A0F4J0T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000787">
        <property type="protein sequence ID" value="KJY27892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950125.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000787.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27892">
        <property type="protein sequence ID" value="KJY27892"/>
        <property type="gene ID" value="VR44_26520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1428"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="27153" checksum="ADD933F88D41418C" modified="2015-06-24" version="1">MGAGTGGVSTGTAARWVERWERQQQRYAVDREERFAVIADLVEHVAGGRPSPLVLDLGSGPGCLAARLAARLPGAEVLAVDADPLLLELGSAHYGRTLRYVNTLIGEPGWVGRLGLDRPVDAVVSTTALHYLGERTLRQVYGELAGLLRPGGILVNGDHISPDSARMSELARDVGRRHAERNADCGHEEDWESWWSGAAGDPELAPLLGQGGEGRAPCEGNDLTVSGHVALLRDAGFADVGVVWQVGPSHVLAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0U1</accession>
    <name>A0A0F4J0U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000786">
        <property type="protein sequence ID" value="KJY27897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27897">
        <property type="protein sequence ID" value="KJY27897"/>
        <property type="gene ID" value="VR44_26485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1482"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="27891" checksum="1168BD238A388ADC" modified="2015-06-24" version="1" fragment="single">LVPGFRRVLGTVTGIAAGLLIAVPLHGAPGPTAALVAVCVFGIFYTAAPSYSWMMFFVTVMAGLLYGLLGVLHPGLLLLRFEETAVGALGAALGVTLVLPVTTHAANDAWIQRALHCVRASTAASLDRLAGDPDADPAPHAAELELLLARVRMALAPLVHPLSPLRARKARARQVLGLLDDCAREVRGLVAVAADPQASHDARLAAACWRVEAAVEALTAPQGAARTGAPVLPAGPAGAEPALAHLHGLETALAALATPLRTDPRAPLVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J186</accession>
    <name>A0A0F4J186_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000768">
        <property type="protein sequence ID" value="KJY28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950065.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000768.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28045">
        <property type="protein sequence ID" value="KJY28045"/>
        <property type="gene ID" value="VR44_26200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1396"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6186" checksum="3436CB23312703AA" modified="2015-06-24" version="1">MFAYVLSCGGLLYVGPAILLCRKVARKTTVRTGWAMALGLVALPAILLAVGAVIDAHSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1H4</accession>
    <name>A0A0F4J1H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000760">
        <property type="protein sequence ID" value="KJY28135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28135">
        <property type="protein sequence ID" value="KJY28135"/>
        <property type="gene ID" value="VR44_26015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="13960" checksum="EE0A1932EAC4C933" modified="2015-06-24" version="1" fragment="single">TSEGASDAATASPPTNRDGEPAAREAAQDTEPRAAGTLTPTGRKQADTDEPAAAEATGSAAPNTPARREPAVAEAGPGTGTASAGAQEEDRAVPDAPDAAVTPSGAGAPAEEETRSGETRAAGRGASGRPGSVKAEDAAAEDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J283</accession>
    <name>A0A0F4J283_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_26370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000779">
        <property type="protein sequence ID" value="KJY27959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950099.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000779.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27959">
        <property type="protein sequence ID" value="KJY27959"/>
        <property type="gene ID" value="VR44_26370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1457"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="37"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="324"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="605" mass="63019" checksum="D376A3353B1566BE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J292</accession>
    <name>A0A0F4J292_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Argininosuccinate synthase</fullName>
            <ecNumber evidence="6 15">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">argG</name>
        <name evidence="17" type="ORF">VR44_28570</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the argininosuccinate synthase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="6 15"/>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950499.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1961"/>
    <dbReference type="EnsemblBacteria" id="KJY27031">
        <property type="protein sequence ID" value="KJY27031"/>
        <property type="gene ID" value="VR44_28570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2043"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00581">
        <property type="entry name" value="Arg_succ_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023437">
        <property type="entry name" value="Arg_succ_synth_type2_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY27031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="484" mass="52559" checksum="564CBC2105D7DAFC" modified="2015-06-24" version="1">MSKVLTSLPVGERVGIAFSGGLDTSVAVAWMRDKGAVPCTYTADIGQYDEPDIASVPGRAQAYGAEVARLVDCRAALVEEGLAALTCGAFHIRSGGRAYFNTTPLGRAVTGTLLVRAMLEDDVQIWGDGSTFKGNDIERFYRYGLLANPHLRIYKPWLDAAFVTELGGRKEMSEWLLAHGLPYRDSTEKAYSTDANIWGATHEAKTLEHLDTGLETVEPIMGVRFWDPSVEIDTEDVTIGFEQGRPVTINGKQFASAVDLVMEANAIGGRHGMGMSDQIENRIIEAKSRGIYEAPGMALLHAAYERLVNAIHNEDTLAQYHNEGRRLGRLMYEGRWLDPQALMVRESLQRWVGAAVTGEVTLRLRRGEDYSILDTQGPAFSYHPDKLSMERTEDSAFGPVDRIGQLTMRNLDIADSRAKLEQYAVLGLIGSGSPAVGAAQAAATGLIGTMPEMPEGGAEAIASRGEVSADEELLDRAAMESGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2J8</accession>
    <name>A0A0F4J2J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000864">
        <property type="protein sequence ID" value="KJY27161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950450.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000864.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27161">
        <property type="protein sequence ID" value="KJY27161"/>
        <property type="gene ID" value="VR44_28315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1908"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470334" evidence="2">
        <location>
            <begin position="32"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="675" mass="72435" checksum="FC94D613F93E3730" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2U5</accession>
    <name>A0A0F4J2U5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_25940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000755">
        <property type="protein sequence ID" value="KJY28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950016.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000755.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28174">
        <property type="protein sequence ID" value="KJY28174"/>
        <property type="gene ID" value="VR44_25940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1288"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="166"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="745" mass="80682" checksum="DCE3C5D707952341" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J379</accession>
    <name>A0A0F4J379_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949801.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000708.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28700">
        <property type="protein sequence ID" value="KJY28700"/>
        <property type="gene ID" value="VR44_24790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.959"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12628" checksum="17A071A978146946" modified="2015-06-24" version="1">MSIQPVPAFEPPYVMAVFSNVRTSDDSGYPEVLSRMNEIVRENPGFLGYESARTPGGLGITVAYFRDHESLTAWRTDLEHQAAMKHGRAHWYESYTLHVATVERSHGFARNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3A9</accession>
    <name>A0A0F4J3A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949780.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2988"/>
    <dbReference type="EnsemblBacteria" id="KJY28730">
        <property type="protein sequence ID" value="KJY28730"/>
        <property type="gene ID" value="VR44_24670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.930"/>
    <dbReference type="eggNOG" id="ENOG502ZXNX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8571" checksum="CC0BDB9B1419ECE9" modified="2015-06-24" version="1">MSSSALSKAKGFKKSKTGTYLSMGTTAFGAISVIKQVRKARTEHDTLQLVDAVVSAAAIVTGLAILYRELKRLGDDDVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3H9</accession>
    <name>A0A0F4J3H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_27510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000832">
        <property type="protein sequence ID" value="KJY27451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950308.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000832.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5378"/>
    <dbReference type="EnsemblBacteria" id="KJY27451">
        <property type="protein sequence ID" value="KJY27451"/>
        <property type="gene ID" value="VR44_27510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1669"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470572" evidence="2">
        <location>
            <begin position="31"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="465"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="613" mass="64788" checksum="E2BCBDC197D653DA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3X0</accession>
    <name>A0A0F4J3X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000682">
        <property type="protein sequence ID" value="KJY29037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29037">
        <property type="protein sequence ID" value="KJY29037"/>
        <property type="gene ID" value="VR44_23910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.757"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="59"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="128"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="36268" checksum="754DADA8DDBAEF25" modified="2015-06-24" version="1">MTRPPVPPRPATVLAMSADTRAAVLRGRALDELLRVADVDPALLLTDFARPGPELGGRLARVEVLFTGWGCPVLDAEALRRMPRLRAVVHAAGSVKGHVTDACWERGLLVSSAAAANALPVAEYTLAAILFSNKRVLAAAHAYRAARGPVDPLARYPAAGNYRRTVGLVGASRTGRRVLELLRPFDLRVLVHDPYADPAELASLGGEACGLDELLGRSDVVSLHAPELPGTRGLLDASRLALMPDGATLINTARGSLVDTAALTRELVAGRLHAVLDHTDPEVLPAGSPLYELPNVLLTPHVAGSLGGELDRLASVAVEELERYARGAGFRHPVDPGRLSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J500</accession>
    <name>A0A0F4J500_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_22950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000643.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29422">
        <property type="protein sequence ID" value="KJY29422"/>
        <property type="gene ID" value="VR44_22950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.527"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="62"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="365" mass="39508" checksum="A94F56AFC2EEF573" modified="2015-06-24" version="1">MNPVVATALDLPYPSPGGSVELFLDLYTGAQPAIPARAFMLAPDGPHPRTPAGLDLLHATGKCIGGDRFNRYVTNLRHALTAAVDPRQISVLHLYHLAFGATPALLRAFPRHPRIAFVHGTDLLYAENHSTQLRVLREAAKAADAIVVPTHAMTDRLLKLAPKTDRRKIEKIPWGVPDQLLTAPPSRPARRRASHLRVLFAGRVSSEKGLEPLLQAEAATPSIELGVAAPRSQFQDLVPVIRQHGVHVRYLGWFRRQQLWKVFADHDVLAVPSTTLEAMGLVALEAQACGLPVLYQPVPGLTEALAGTGMATDFTTPATAAHDLNRLRTTPGLLELLRAAGRTNAARFPLSATASAITDLGRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6H0</accession>
    <name>A0A0F4J6H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949191.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29947">
        <property type="protein sequence ID" value="KJY29947"/>
        <property type="gene ID" value="VR44_21490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.176"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="31031" checksum="988C9469585EEAC8" modified="2015-06-24" version="1">MHEEIQRVAQVEPPVERAKAAIALMGDYQGRVTELSRIRREAIEEAAASGMSQSEIAALLGVSRGRVGQLAAQGPPPERAFFGTDLMTISLGGKYEAGKETGEAGEVVTREDFGNFEHLRKLLSTLKLDAQYEVIPPTGIVNLNRDNHVVVCGPRLSPIIAQVLEGDDHLRFQKDRAWHLVDLKTKEVHRSPMDESGEAGDVGYLARLPRLDGKGTFIYIAGIHAIGANGVVHYLENHLAELYREVRTNRFSTLISCRYDPKTLEVLESKRVSPIYRHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6R5</accession>
    <name>A0A0F4J6R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28616">
        <property type="protein sequence ID" value="KJY28616"/>
        <property type="gene ID" value="VR44_24990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1086"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10475" checksum="03877093A0CB5A92" modified="2015-06-24" version="1">MTDEVSGSLPDVPQEPETEPVKEPVTEPAAEPAGTAPLGLVRTPTGHPGVDAHLERLADADHLAADGHVEVYEDVHRGLREALDALDAQPVPGPYENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7D1</accession>
    <name>A0A0F4J7D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000625">
        <property type="protein sequence ID" value="KJY29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949353.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000625.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene469"/>
    <dbReference type="EnsemblBacteria" id="KJY29678">
        <property type="protein sequence ID" value="KJY29678"/>
        <property type="gene ID" value="VR44_22345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.357"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36871" checksum="3CCF063B57259235" modified="2015-06-24" version="1">MPAQQPAVSVIMPVLNEERHLRDSVRHILGQEYAGEMEVVIALGPSTDRTDEIAAELVREDPRVHTVPNPTGRTPAALNAAIKASRHPIVVRVDGHGMLSPNYIATAVRLLEETGAQNVGGIMHAEGENAWEEAVAAAMTSKIGVGNAAFHTGGQAGPAETVYLGVFRREALEQQGGYNEEFIRAQDWELNFRIREAGGLIWFSPELKVQYRPRPSVRALAKQYKDYGRWRHVVARYHAGSINARYLAPPTAVCAIAAGLVAGVAVTPWAFAVPAGYLAAITAGSVPAGKGLPLKARARIPVALATMHMCWGYGYLTSPRSLARKVIASRRPSVRRDPAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9U5</accession>
    <name>A0A0F4J9U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948959.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30513">
        <property type="protein sequence ID" value="KJY30513"/>
        <property type="gene ID" value="VR44_20230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8753"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23501" checksum="8A532FE05F0A1856" modified="2015-06-24" version="1">MHVQEWLETIPAISVYLLVGLVIGLESLGIPLPGEIILVSAALLASQQGHIDPVVLGLCAIAGAIVGDSIGYAIGRRGGKPLLEKLGRRFPKHFGPEQVAVAERSFDRWGMWAVFFGRFVALLRIFAGPLAGVLRMPYWRFLIANVLGGVLWAGGTTAVIYTVGIVAEPWLKRFSWLALVAALLLGLVVTLVVRARMKKAAAAAREEADARVTTPAGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z3</accession>
    <name>A0A0F4J9Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949304.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000615.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29796">
        <property type="protein sequence ID" value="KJY29796"/>
        <property type="gene ID" value="VR44_22075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.295"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="126"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="30387" checksum="F5442B4291C34A1A" modified="2015-06-24" version="1">MGTVTALCRYPVKSMLGEALTSVRITEEGLAGDREFAVLDEAGAVASAKHPRKWGALLDCRSRSAGPGAARVELPGGDVLPAGGAELDARLSALLGRRVAVSGEPPEQGLLERAVPDYEGGLPEVLRPRASVDSTGGTITAGRVAAGTFFDFGRVHLVTTNSLRSLRRTHPAGDFDPLRFRPNLVVDLPGGPGFPEDSWQGGTLRIGPALFRVVVPTPRCVVPNLGHGELPPDVGIMRAVAREHRVPVLDLGRLSCVGVYLEVLEPGTVRTGDEVTVHPDPAIRRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z9</accession>
    <name>A0A0F4J9Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000555">
        <property type="protein sequence ID" value="KJY30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30568">
        <property type="protein sequence ID" value="KJY30568"/>
        <property type="gene ID" value="VR44_20175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8740"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="478"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="763"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="931" mass="99337" checksum="0E4E332134539EA9" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA08</accession>
    <name>A0A0F4JA08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_21990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949286.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29811">
        <property type="protein sequence ID" value="KJY29811"/>
        <property type="gene ID" value="VR44_21990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.278"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27622" checksum="BA9EC2C5491B2EBE" modified="2015-06-24" version="1">MLVHSKGGRWAAWSLFGILFVPLFALPLLVVVAASFATRWSGAFPSGPTTANYASAVQGESLQALTTSLVTALAASLLALTAGTWAALAAAALGRRGKRVLDALFMLPVAVPSVVVGLAVLVAFSRPPLLLNGTSTIVVLAHAILVTAFAHQSVSAAIVRLDPAYEQAAASLGARPAYVLWRVRIPLLLPSLTAAAGLCFALSMGELSATMMLYPPDWMPLPVRIFTATDRGSLFGGSAVAVVLMATTLLVLLAVSRVRTRASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAA3</accession>
    <name>A0A0F4JAA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_19820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3115"/>
    <dbReference type="EnsemblBacteria" id="KJY30678">
        <property type="protein sequence ID" value="KJY30678"/>
        <property type="gene ID" value="VR44_19820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8583"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="432" mass="46006" checksum="376924EF91DBA135" modified="2015-06-24" version="1">MREYLLTLCVTVAVTYLLTGPVRKFAIAAGAMPEIRARDVHREPTPRLGGIAMFGGLCAGLLIADHLQSLNGVFERSNEPRALLSGAALIWLVGVLDDKFELDALIKLGAQMIAAGVMVIQGLTILWIPVPGIGTVALTQWQGTLLTVALVVITINAVNFVDGLDGLAAGMVCIATCAFFLYAYRIWFGYGIEAAAPATLFAAILMGMCLGFLPHNMHPARIFMGDSGSMLIGLVLAASAISITGQVDPDTMALFVGGERNATHAMLPVFIPLLLPLTIIAIPMADLVLAIVRRTWKGQSPFAADRGHLHHRLLELGHSHSRAVLIMYFWSGLIAFGTVAYSVNSASMWIVLAIAALSALGLVLLLLPRFTPRAPRWAEGLVPPRYRHARRAAEAAAEAARPIAAGVSGVNGATAVGPRSRFPDRRKAGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAC4</accession>
    <name>A0A0F4JAC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000514">
        <property type="protein sequence ID" value="KJY31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948689.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4131"/>
    <dbReference type="EnsemblBacteria" id="KJY31140">
        <property type="protein sequence ID" value="KJY31140"/>
        <property type="gene ID" value="VR44_18760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8363"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="443" mass="47964" checksum="96E113DAB7B7C10B" modified="2015-06-24" version="1">MTEQNEKQSLVGEEYEVEVGPVAHGGHCIARTADGRVLFVRHTLPGEKVIARVTEGEAGSRFLRADAITVLTASKDRVEAPCAFAGPGKCGGCDWQHAKPGAQRRLKGEVVAEQLKRLAGLTPEEAGWDGTVAPAEGDKLPAGEVPQWRTRVQYAIDEDGRVGLRKHRSHDIEPVDHCMIAAPGVTELGIEKRSWPAMASVEAIAASGSNDRQVVLTPRPGGRLPLVELDKPVSVLRVEEKDGGVHRVHGRPFVRERADGRTYRVGMGGFWQVHPQAADTLIKAVMQGLMPRKGEMALDLYCGVGIFAGALAERLGETGAVLGIESGKRAVEDARHNLADFPRVRIEQGKVDTALPRTGITECDLIVLDPPRAGAGKQTVRHIASLSARRIAYVACDPAALARDLGYFKEAGYKVRTLRVFDLFPMTHHVECVAILEPVEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAV4</accession>
    <name>A0A0F4JAV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">VR44_18360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000499">
        <property type="protein sequence ID" value="KJY31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948612.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000499.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000063_gene1476"/>
    <dbReference type="EnsemblBacteria" id="KJY31340">
        <property type="protein sequence ID" value="KJY31340"/>
        <property type="gene ID" value="VR44_18360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8221"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="9"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="33294" checksum="299C61F621847CFA" modified="2015-06-24" version="1">MNSRPDQPLRLGTRRSKLAMSQSGHVAEAVRAVTGRPVELVEITTYGDVSRENLAQIGGTGVFVTALRDALARGEVDFAVHSLKDLPTTQPDELVIAAMPEREDPRDALVARDGLTFEQLPDGARVGTGSPRRMAQLNAYAKSLGKSIECVAIRGNVDTRIQFVRDGELDAVVLAAAGLNRIGRGDEATDLLSVDNVLPAPGQGALAVECLASDTELVAALGRLDDPYTRAAVTAERALLAALEAGCSAPVGALADGQTVNEMRLRGVVGTLDGSTLVQLSTTGPVPQSYDEAMALGRELADEMLAKGAAGLMGERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAZ2</accession>
    <name>A0A0F4JAZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948542.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5642"/>
    <dbReference type="EnsemblBacteria" id="KJY31522">
        <property type="protein sequence ID" value="KJY31522"/>
        <property type="gene ID" value="VR44_18010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8147"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="29520" checksum="5364D6C631CE63C1" modified="2015-06-24" version="1">MTTYDARFRVWRGDAEGGDLRDFTVEVHDGEVVLDIVHRLQATQAPDLAVRWNCKAGKCGSCSAEINGRPRLMCMTRMSVFDRTETVTITPLRAFPVVRDLVTDVSFNYEKARSVPAFVPPAGLAPGEYRMQQVDVERSQEFRKCIECFLCQDTCHVVRDHEENKPAFAGPRFLMRVAELDMHPLDAAEETGLDRKRTAQEEHGLGYCNITKCCTEVCPEGIKITDNALIPLKERAVDRKYDPLVWLGTRIRRRSASDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB04</accession>
    <name>A0A0F4JB04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_18260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948589.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31395">
        <property type="protein sequence ID" value="KJY31395"/>
        <property type="gene ID" value="VR44_18260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8199"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18235" checksum="357A6718D22CA3E8" modified="2015-06-24" version="1">MTPADRERGITLARAARAGNTLALHELLDHLTPYVTRICTPIALADGPDAAQEALLAVFTALRSLRDPDALYGWVRAIAVREAVRTAQRASRARPAPDLTAVPAKGDPQLASDIEDVLARLSPAHRAVLVLRDVEGLDEEAAAAVLNIPPGTAKSRLHRARSSFRKAWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBE7</accession>
    <name>A0A0F4JBE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948734.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31063">
        <property type="protein sequence ID" value="KJY31063"/>
        <property type="gene ID" value="VR44_19010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8406"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY31063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27713" checksum="9B4048AB6C5E7EBB" modified="2015-06-24" version="1">MSQNFPSSASPSGAALAEPAARADGLTKTYGRGETRVTALDAVSVDFARGRFTAVMGPSGSGKSTLMHCMAGLDPVTSGSARIGGVELSSLNDRQLTRLRREKVGFVFQGFNLMPTLTALENITLPLRLAGRKPDPAWLDTIVATVGLSGRLAHRPAELSGGQQQRVAVARALVSRPEIVFADEPTGNLDSRSGAEVLGFLRDSVRELGQTVVMVTHDPVAAAHADRVVFLADGRLVDELYEPSSGAVLDRMLAFEGRGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBH9</accession>
    <name>A0A0F4JBH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948723.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000518.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3420"/>
    <dbReference type="EnsemblBacteria" id="KJY31093">
        <property type="protein sequence ID" value="KJY31093"/>
        <property type="gene ID" value="VR44_18935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8328"/>
    <dbReference type="eggNOG" id="ENOG502ZVAX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046040">
        <property type="entry name" value="DUF5998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19461">
        <property type="entry name" value="DUF5998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20412" checksum="633AC276228C8596" modified="2015-06-24" version="1">MAKSGTTTQGLRAAIERSGYYPALVAEAVEAAVGGEPVSSYVVHQETTFDSNEVRRHVTVLVLTDNRFIVSHTDEQAADAGSPSPYATTSTESVKLGSISSVVLSRVVANPESYTPGQLPREVVLTIGWGAVSRIDLEPAACGDPNCDSDHGYTGNSTADDLSLRVSEAGDGPETVRQTLLFAQALSEATAATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBI3</accession>
    <name>A0A0F4JBI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000571">
        <property type="protein sequence ID" value="KJY30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30346">
        <property type="protein sequence ID" value="KJY30346"/>
        <property type="gene ID" value="VR44_20715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8859"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6086" checksum="7291A1F3E0290249" modified="2015-06-24" version="1" fragment="single">TWLAAGATAVGVGTGLPTHPEELAALFADLAAYPAASGGSPPRAPEPGRAAPDAGPVAAPRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCD5</accession>
    <name>A0A0F4JCD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Menaquinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000492">
        <property type="protein sequence ID" value="KJY31454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948561.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000492.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene916"/>
    <dbReference type="EnsemblBacteria" id="KJY31454">
        <property type="protein sequence ID" value="KJY31454"/>
        <property type="gene ID" value="VR44_18105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8168"/>
    <dbReference type="eggNOG" id="COG1427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="30052" checksum="769F6232354DD856" modified="2015-06-24" version="1" fragment="single">MDVYRSRPRVGHIQFLNCLPLYWGLARTGTLLDMELTKDTPEKLSERLVQGDLDIAPVTLVEFLRHADQLVALQDIAVGCDGPVMSCVIVSQVPLEQLDGARVALGSTSRTSVRLAQLLLAEQYGVRPDYYTCPPDLGLMMQEAEAAVLIGDAALRASLHDAPRLGLAVHDLGRMWKEWTGLPFVFAVWAARKDYLAREPEIVREVHDAFLASRDLSLEEVVKVAEQAARWEAFDAGLLQRYFTTLDFRFGPEQLAGVREFARRTGADTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCZ6</accession>
    <name>A0A0F4JCZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000428">
        <property type="protein sequence ID" value="KJY32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32227">
        <property type="protein sequence ID" value="KJY32227"/>
        <property type="gene ID" value="VR44_16350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7727"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="27912" checksum="992338381A03D9A1" modified="2015-06-24" version="1">MCVLRGRSTAAVEPAELTLILLHHAGGSAGSFVPLLPHLPESWRILAPELPARATAPRQPVCPSVTSAVDSFAEELTGQLSGPYAVFGHCLGSLIAFELVHALAARGHHRPLWVGVSGSPAPRLVVPEPADGPPEDWTREQYVAYMRRLGATPEELWNNTLLADRMITALRNDLVVNHGYRYQDRAPLASPLSVMRGDGDPLVTAEEMRPWADHADATEFRSWPGDHFYLFDRAPEVSAGIVGAITAAAAHIETTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDJ1</accession>
    <name>A0A0F4JDJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_16225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000422">
        <property type="protein sequence ID" value="KJY32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948209.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000422.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32275">
        <property type="protein sequence ID" value="KJY32275"/>
        <property type="gene ID" value="VR44_16225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7668"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="17998" checksum="45523183473B497D" modified="2015-06-24" version="1">MTSTKQHTVVDSPYGELTLVATDGVLSGLYMTGQRHRPAEESFGERVAAAEEPFPEVVRQLTAYFAGELTEFTVPVRLEGTAFQRSVWEQLVRIPYGQTWSYGRLAAELGKPGASRAVGLANGKNPVGIIVPCHRVIGASGSMTGYGGGIERKVRLLEFESRGTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDV2</accession>
    <name>A0A0F4JDV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948374.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31918">
        <property type="protein sequence ID" value="KJY31918"/>
        <property type="gene ID" value="VR44_17115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7955"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="19359" checksum="68C7123A04C4F19F" modified="2015-06-24" version="1">MNPQAPVHAADDHWLTVVYYRFRAWRGERPFWAGLFTLLGGVPIVYFPFADIRLGNVTLAMATTTGSGSLIIGILLITLGLALWFQKGIRVFAGVAAILLALVSIPLSNLGGFFIGFLTSMVGGCLALAWAPGVPVEEEPEQAEAAEGAPVDPFHGIPGPRGTETPYLTEKTAHADGGRNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFJ5</accession>
    <name>A0A0F4JFJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000405">
        <property type="protein sequence ID" value="KJY32574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948114.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32574">
        <property type="protein sequence ID" value="KJY32574"/>
        <property type="gene ID" value="VR44_15720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7547"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28329" checksum="5A48405A9DD03706" modified="2015-06-24" version="1">MTPATPSDEIRHRFENGVSWITLNRPDAMNALTWDQRERIIALLADASADPATRAVVLTATGKGFCAGADLRSGGGAPATTDRVAGDVARMIRLGAQRLVTAVLDCEKPVIAAVNGTAAGIGAHLALACDLVIAAEPARFIEVFVRRGLVPDGAGAYLLPRLLGPQKAKELMFFGDAVPAAEAARLGLVNKVVPADELEAAAREWAERLAQGPTRALALTKQLVNASLDGDRATALAAEATAQELNMTTADANEGVASFVERRTPKYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFP9</accession>
    <name>A0A0F4JFP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000402">
        <property type="protein sequence ID" value="KJY32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948092.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000402.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32629">
        <property type="protein sequence ID" value="KJY32629"/>
        <property type="gene ID" value="VR44_15605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7521"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="32184" checksum="F056908242E20D72" modified="2015-06-24" version="1">MSAATTRSRTPRTPRTPAPDRLCAEAVELAREAAEEAAHPGVVGEHVSVVAEGDRVVTHFFECHEPGYRGWRWAVTVTRASRAKNVTLDETVLLPGDDALLAPEWVPWSERLRPGDMGPGDLLPTDAEDLRLEPGYSGEDAPPPNSAVSAEMAELVEAEDADVTDRVVAPARGSITSVAEELGMRRARVLSRYGLHTAADRWDEAFGAKTPMAQAAPASCVSCGFLVAIGGSLGQAFGVCANEFGPADGRLVSLSYGCGGHSEAAVMPKPPRPAEMAIDEFPLRPAADTGSVPVVDLPSEDLGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIU0</accession>
    <name>A0A0F4JIU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947712.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000345.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33688">
        <property type="protein sequence ID" value="KJY33688"/>
        <property type="gene ID" value="VR44_13490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6948"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="5">
        <location>
            <begin position="48"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="239"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="43214" checksum="DF9CBE81D8DBFFEA" modified="2015-06-24" version="1">MAAVAVWAGLLGGLTGCTGDGRSPVEVQLPGKPRSPDEAIRITPDDNAKGVPADGPLRVHVPEGRLERVTVTKVEDAQEEQVPGSIAADGLSWSPDPEAGRLALAAKYTVDAVALDGHNRRQARHTTFTTYVPEERFIGYFKPENRSTVGTGMIVSFKFSRAVKNRAEVERAITVTAEPAVPVVGHWFGSERLDFRPKEYWKPGTQVTVKIKLRDVEGAPGAYGIQDKTVRFTIGRSQISTVDAAAHTMEVRRGGELLSTIPISAGAPKNTTYNGKMVVMEMFDVTRMNGATVGFTSEDGKGEYDIPDVPHAIRLTASGTFLHGNYWASPDTFGTTNTSHGCVGLRDDKGGGSDTPAGWFFDRTLIGDVVEVVNSQDKTVAPNNGLGGWNMSWADWVAGSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJG4</accession>
    <name>A0A0F4JJG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">VR44_12905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000325">
        <property type="protein sequence ID" value="KJY33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000325.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33934">
        <property type="protein sequence ID" value="KJY33934"/>
        <property type="gene ID" value="VR44_12905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6698"/>
    <dbReference type="eggNOG" id="ENOG5032RUK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8402" checksum="A7A6A18B40F0B570" modified="2015-06-24" version="1">MSMNTTSAPAWYDLALCAQTGPSFFFPEPGSSLQDAKRLCGACEGRAACLEYALANDERFGVWGGLSEAERLALRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJW7</accession>
    <name>A0A0F4JJW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000275">
        <property type="protein sequence ID" value="KJY34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947354.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000275.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34632">
        <property type="protein sequence ID" value="KJY34632"/>
        <property type="gene ID" value="VR44_11580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6227"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471117" evidence="2">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="11665" checksum="78301A0B0B8A680C" modified="2015-06-24" version="1">MTGKLVTRLSVAAASTFAAVALFGATPALAATAGDDEQAQQIQQAQEHLRDAEREADPEAAAERDTERRIAADKRDIEDGLAGNGNRAAQAAEDLQAVADEQDAAEGDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLM6</accession>
    <name>A0A0F4JLM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947169.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35247">
        <property type="protein sequence ID" value="KJY35247"/>
        <property type="gene ID" value="VR44_10575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5859"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="37754" checksum="199403874E4EF6D4" modified="2015-06-24" version="1">MEYRQLGASGLKVPALGFGAGTFGGQGPVFGAWGSTDTQEARRLVDICVDAGITLFDTADVYSAGASEEVLGEAVKGRRDQVLISTKAGLPTGDGPGEYGTSRSRLITAVENALRRLGTDHIDLFQLHGFDAATPVEEVLSTLDQLVRSGKVRYTGVSNFAGWQLMKSLSVADRHGFPRYAAHQVYYSLVGRDYEWELMPLGHDQGVGAIVWSPLGWGRLTGKLRRGRPLPAGSRLHATADYGPPVEDAHLYDVVDALDEIAQETGRTVPQVAINWLLRRPTVSTVLIGARDEQQLRQNIGAVGWELTADQIARLDAASHRPAPYPYFPYERQEGFALLNPPMTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLP4</accession>
    <name>A0A0F4JLP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34739">
        <property type="protein sequence ID" value="KJY34739"/>
        <property type="gene ID" value="VR44_11445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6187"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="166"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="32068" checksum="65C4B18F5E3FFDBF" modified="2015-06-24" version="1">MSRTVVVGLDGSPASSAAAEWAANEARLRRLPLKLLHAVERWAPPYGYASLAGTSAPVPASTEYWGEHIPQDVFQQLTERHPGLEMTTEQVDGRPVTVLTDAAQEAEVLVLGSRGLGAMTGFLVGSVSQAVLAHAERPVVIVRTGSGTDSAHLPTPDGSGPQEGAYRPVVLGLDLARPCDELLEYAFDAAAARRAPLRVVHGWSMPPAYGFDPALIAPEVRDGIAAGAAGALGDALRPWRGKYPEVRVEEECAVGRAAGHLVAASANASLMVVGRRVRHSAIGTHLGPVAHAVLHHSAAPVAVVPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLQ6</accession>
    <name>A0A0F4JLQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IucA/IucC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_10850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947220.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35120">
        <property type="protein sequence ID" value="KJY35120"/>
        <property type="gene ID" value="VR44_10850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6021"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="163"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="437"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="618" mass="68607" checksum="BFC396ABB899A054" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMN6</accession>
    <name>A0A0F4JMN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946992.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35627">
        <property type="protein sequence ID" value="KJY35627"/>
        <property type="gene ID" value="VR44_09615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5371"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="170"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="30459" checksum="7EE22FD90850BFA5" modified="2015-06-24" version="1">MTVHPSLEPYVDAWTHSIEAITELVLPLTEGQWNLPTPCPGWSVRDVVSHIIGLELEQLGDPRPIHTLPRDLRHVVDEFTRYMEVPVDVRRHHTALEMTSELEYTVIRRQRQFRNDKRDPATTLVRGPKGDQIPLELSMRLRAFDVWIHEQDLRAALGVPGNWDAPGAHVARDILLSGLPKVVAKGAGAPPNTAVVLDVHGPLEFLRTVRVDAAGRATLDPTPSLGPAVSLSLDWETYVRLAAGRVRPRTVADRVKVDGDAELAEAILANFAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPW4</accession>
    <name>A0A0F4JPW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000170">
        <property type="protein sequence ID" value="KJY36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946758.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000170.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36230">
        <property type="protein sequence ID" value="KJY36230"/>
        <property type="gene ID" value="VR44_08375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4574"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471129" description="DUF305 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="53"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24733" checksum="8139F15432B743C9" modified="2015-06-24" version="1">MTRSRTNRTYWAAGTAVVLAALFAAGATFATADGSEDRGGSSASGTPALYSPDAGFARDMAVHHQQAVEMSFIVRDRTQDEPVRGLAYDIANTQANQRGMLLGWLDLWGLPKVVADEPPMSWMETDSSAGHDGHGGQGGHEGHVTKPGALMPGMATKEELDRLGAAGGRDAEVLYLQLMTEHHKGGVAMAQGCAKQCRTPAERALAQGMVEAQQSEMKLMADMLKQRGAAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQJ0</accession>
    <name>A0A0F4JQJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946779.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36119">
        <property type="protein sequence ID" value="KJY36119"/>
        <property type="gene ID" value="VR44_08485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4760"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26606" checksum="1D07AEA0D4721D1A" modified="2015-06-24" version="1">MTADAVNTGISLGMPQLPAPDFPAEVRARLEADAQEVIARYPDSRSALLPLLHLTQSEEGYVSRTGIRFCAEVLGLTTAEVTAVATFYTMYRRKPSGDYQVGVCTNTLCAVMGGDAIFDELKEHLGVGNNETTPDGKVTLEHIECNAACDYAPVVMVNWEFFDNQTPASAKALVDDLRAGRPVEPTRGAPLCTFKDTARILAGFPDGREGAVEASGGAGPASLIGLRIARGESPHAPVVRPRAETGTEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQK7</accession>
    <name>A0A0F4JQK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946612.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene565"/>
    <dbReference type="EnsemblBacteria" id="KJY36647">
        <property type="protein sequence ID" value="KJY36647"/>
        <property type="gene ID" value="VR44_07575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3992"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26835" checksum="71A7D4A27960E0E5" modified="2015-06-24" version="1">MSRVPSLEVSGVAYAYPDGHQALFGVDLTVGRGERVALLGPNGAGKTTLVLHLNGILGGGVGSVTVAGLPVEKRNLAEIRRRVGIVFQDPDDQLFMPTVREDVAFGPAAAGLRGAELEQRVREALEQVGMAGFADRPPHHLSFGQRRRVAVATVLAMRPEILVLDEPSSNLDPASRRELADILRALDVTVLMVTHDLPYALELCPRSVILSEGVIAADGRTRDLLCDEELMGAYRLELPFGFDPRSVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQM3</accession>
    <name>A0A0F4JQM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000146">
        <property type="protein sequence ID" value="KJY36662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36662">
        <property type="protein sequence ID" value="KJY36662"/>
        <property type="gene ID" value="VR44_07500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3975"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20404" checksum="BBB78A81800F4307" modified="2015-06-24" version="1">MSNSYTTLWTNDLCRELGRSGYAGRRLTMLFGGPHQSLPSFRRAGVRPGDRIYPVRALATRLHVLGAMEVSRIIPYEDAGSVLHDDDYAKLLEWRPLKTGCVTEVVTGPPGSALTFGTTVPPDLLERLTYTSRRGERTLKYVDEGRLIRSVSLQGIYRLTSASAAELHRLVLDGSVSARRQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQW5</accession>
    <name>A0A0F4JQW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000150">
        <property type="protein sequence ID" value="KJY36570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36570">
        <property type="protein sequence ID" value="KJY36570"/>
        <property type="gene ID" value="VR44_07750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4253"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6407" checksum="D417D32C36AFE66D" modified="2015-06-24" version="1" fragment="single">MRVVGLMSGTSYDAVDAAAAHLTLEDGGETLRLLPLGMVSAPYEEALRAELAAALPPAPTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRP0</accession>
    <name>A0A0F4JRP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000157">
        <property type="protein sequence ID" value="KJY36494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946673.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000157.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36494">
        <property type="protein sequence ID" value="KJY36494"/>
        <property type="gene ID" value="VR44_07910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4403"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="entry name" value="PTHR36124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="44"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="34508" checksum="81062152D1BFED62" modified="2015-06-24" version="1">MQRYDRLKEILRLDPDKDFLAIYRLTATYEFPWDFTRALELALFRTYAVPSIGSLLAETAEFTERPQKRYDDTALLLDAVVEHGFDHDTARTAIRRVNQMHRSYDISDDDMRYVLCTFVVIPSRWIDAYGWRPLTHHERRACANYYATLGRHLGIKDVPGSFEEFEATLDAYEEAHFGWDEGGRAVADSTLGLMASWYPAPLAPAVLRASRALLDEPLLEAFRYERPHPVVSRLVHGALRLRGRAVRLLPPRKAPHYARQNPEIKGYPHGYDVGELGTFPVPGASGCPVPHPRRPAGADAQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS22</accession>
    <name>A0A0F4JS22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946598.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36634">
        <property type="protein sequence ID" value="KJY36634"/>
        <property type="gene ID" value="VR44_07530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3983"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="34493" checksum="070FCE0A85ABA1DA" modified="2015-06-24" version="1">MNRPQHVTAGRYAPPAAGRELVAVSADGSRLHVEVHGADGAPAVVLSHGWTCSTAFWAAQIRELARDHRVIAYDQRGHGRSPAAGSYSTTALAADLVAVLEATLAPGERAVVAGHSMGGMTVMAAAGQPRFTEHAAAVLLCSTGSSRLVAEATVLPLRPGRARTRITRGLLGSPAPLGPVTPATRAVLKYATMGPGSAPERVEACARIVHACPAGVRRAWSQVLAGLDLDEGVARLTVPTAVIVGRDDRLTPVVHARGLAAALPHCVGLTELTGMGHMTPIEAPEAVSSALRELTSRYLTTRAAATTGTATSTATTAAAPPVATAPTAPTEKEKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUZ2</accession>
    <name>A0A0F4JUZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_04655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37970">
        <property type="protein sequence ID" value="KJY37970"/>
        <property type="gene ID" value="VR44_04655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1012"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="959"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1051" mass="110598" checksum="8AAF3D0BF797028E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVF4</accession>
    <name>A0A0F4JVF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946161.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37733">
        <property type="protein sequence ID" value="KJY37733"/>
        <property type="gene ID" value="VR44_05150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1345"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17746" checksum="B85CAA5FAB40EF6C" modified="2015-06-24" version="1">METGTTGETDRPAWAGLPGGLLSLRRLLLVVWTAVLTAATALPLGLLAGAEWAALGAIWLPALVWGWVLLGRNWRSWRYAERADDLLISRGVLWHRETVVPYGRMQLVEVTSGPFERRFGLASVQLHTAAAATDAKIPGLAPDEAERLRDRLTELGEARSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVH5</accession>
    <name>A0A0F4JVH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946142.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37753">
        <property type="protein sequence ID" value="KJY37753"/>
        <property type="gene ID" value="VR44_05060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1327"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="16600" checksum="F7CD5FABB2E5EBE8" modified="2015-06-24" version="1">MKQLRPAVLAGIFVIAGVLSWAGARLWNAYGTLPGVPLAAPIVLAVIAVVLFATALSLRARLKAQRERRPGAKGVEPLMAARAVVFGQASALVAALVAGMYGGVGVFLLTDSLDVPARRDQTWYAGGSVLAGAAVIAAALFLEHVLKLPDDEDPAKAHAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW56</accession>
    <name>A0A0F4JW56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946056.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000024_gene6386"/>
    <dbReference type="EnsemblBacteria" id="KJY37958">
        <property type="protein sequence ID" value="KJY37958"/>
        <property type="gene ID" value="VR44_04615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1004"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="40582" checksum="BF15A7A79FCF7EE1" modified="2015-06-24" version="1">MQFGIFTVGDITTDPTTGRAPGEHERIKAMLAIAQKAEEVGLDVFATGEHHNPPFVPSSPTTLLGYLAARTENLILSTSTTLITTNDPVKIAEDFAMLQHVADGRVDLMLGRGNTGPVYPWFGKDIRDGIDLAIENYALLRRLWDEDTVTWKGKFRTPLQSFTATPRPLDGVAPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWPASHTRQMVNLYRERYAHYGHGTPEQAVVGLGGQVFMRRNSQDAVREFRPYFDNAPVYGHGPSLEEFTSQTPLTVGSPQQVIERTLSFRDYAGDYQRQLFLVDHAGLPLKTVLEQLDLLGEEVVPVLRKEFANLRPAGVPDAPTHAARVAAAAATAHEETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWC3</accession>
    <name>A0A0F4JWC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945885.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38435">
        <property type="protein sequence ID" value="KJY38435"/>
        <property type="gene ID" value="VR44_03625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8263"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7333" checksum="806F42C6C627D66B" modified="2015-06-24" version="1">MNTFLDYLTVLAVAALLLAPSLRGLLHERRIDRQLRPEREKPGRGQVSRPGSSRKRGAVRVAGLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWI6</accession>
    <name>A0A0F4JWI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">VR44_05835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030030523.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000108.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37351">
        <property type="protein sequence ID" value="KJY37351"/>
        <property type="gene ID" value="VR44_05835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1982"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9227" checksum="B161071173916ACB" modified="2015-06-24" version="1">MANIKSQIKRNKTNEKARLRNKSVKSELRTFIRKANEAILAGDAEKATAAARLASKKLDKAVSKGVIHKNAAANKKSALASKVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXR2</accession>
    <name>A0A0F4JXR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000092">
        <property type="protein sequence ID" value="KJY37786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946126.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37786">
        <property type="protein sequence ID" value="KJY37786"/>
        <property type="gene ID" value="VR44_04960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36931" checksum="357B43FC138DB583" modified="2015-06-24" version="1" fragment="single">GFLRRGWERGWRPADVERLVRRDLGEVHVRVLGDLVAAEARRYARLPDGWGAGEVWWSGDEAYAEGLARRERADRFTLATAVLELYRLLVRLPSVEPVGPVPGDPAGDLAEHAHIEPRMLGRIRALLAKAEATTYPEEAEALSAKAQELMARHTVDEALLAVRGGGPAQVPGACRIGVEPPYEEAKAVLLDAVATANRCRAVWNSAFEFSTVVGFESDLEAVELLFTSLLVQGTAAMTRAEAAQRAGGRKRTKTFRQSFLLAYASRLGRRLAETAEHTAAEAPDNLPALVARDVAVTSRADEMFPRTTTTRLRGATDHAGWEDGTAAADAAHVGGKRASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXT0</accession>
    <name>A0A0F4JXT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945796.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6543"/>
    <dbReference type="EnsemblBacteria" id="KJY38644">
        <property type="protein sequence ID" value="KJY38644"/>
        <property type="gene ID" value="VR44_03115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7838"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="23757" checksum="37D8D88A8F9F4956" modified="2015-06-24" version="1">MSTPIRVMIADDQMMVRQGFTVLLNSQPDIEVVGQAVDGADAVAQAAELGPDVVLMDIRMPGMGGIEATSVITAVPDCAVKVLVLTTFDLDEYVYEALRAGASGFLLKDASADQLAEAVRVVAAGEALLSPNITKRLITEFSRLGAPRAPSRARLQDLTERETEVLSLIAQGLSNAEIAGHLVLAEQTVKTHVGRILVKLGLRDRTQAAVFAYETGLVRPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY05</accession>
    <name>A0A0F4JY05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanamide hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945816.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38613">
        <property type="protein sequence ID" value="KJY38613"/>
        <property type="gene ID" value="VR44_03225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7861"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21154" checksum="CC7B82DE7B9BD8CF" modified="2015-06-24" version="1">MTWTLHQPDSDSARRAFEIASEYADAALLNHSVRSYAFGAEYARQHGLAYDAELLYVSSLLHDLGLTAPFDSHTLPFEEAGGHVARVFTAGLGWEPARRARAEEVIVLHMREDVTAAEDVESHLLQVGTSADVSGLRVPDFDPAFRTALLAAHPRLGFGPSFLALVEDQAARKPSCAAAAYVAGGAAERIAANPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ72</accession>
    <name>A0A0F4JZ72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecG_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000070">
        <property type="protein sequence ID" value="KJY38321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene780"/>
    <dbReference type="EnsemblBacteria" id="KJY38321">
        <property type="protein sequence ID" value="KJY38321"/>
        <property type="gene ID" value="VR44_03805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecG_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10638" checksum="77410F40E52BE420" modified="2015-06-24" version="1" fragment="single">PARARLAAVAATLDGFELSRIDLEQRREGDVLGQAQSGVRSSLRMLAVIEDEEVIAQAREEATRVVAADPELEHLPGLRTALDALLDTEREQYLEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZG4</accession>
    <name>A0A0F4JZG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_02225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945629.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6050"/>
    <dbReference type="EnsemblBacteria" id="KJY39103">
        <property type="protein sequence ID" value="KJY39103"/>
        <property type="gene ID" value="VR44_02225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5710"/>
    <dbReference type="eggNOG" id="COG3648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="34520" checksum="75C600D5328CF50C" modified="2015-06-24" version="1">MSKHVLGQNQYGKAENRIVVVTRKGSDGSWAEIRDLNVSVALRGEFRDVHLTGDNANCLPTDTTKNTVYAFGKEHGIASPEAFGILLAKHFVSSQAPIREAQIRIEEFAWERIPVPTRKEQHSFVRKGQEVRTAQVTYSETTGLQVISGLKDLTVMNSTNSEFHGFIKDKYTTLQEAYDRILATKVTSRWAHSALAADDAGYDWDRSYKKVRKHMLEAFAETYSYSLQQTLNQMAERVLDNCPKVNEVRLNLPNKHHFLVDLEPFGLKNDNEVYFAADRMYGLIEGTVHRDGVQPVIATSDWIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZZ7</accession>
    <name>A0A0F4JZZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945804.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6552"/>
    <dbReference type="EnsemblBacteria" id="KJY38601">
        <property type="protein sequence ID" value="KJY38601"/>
        <property type="gene ID" value="VR44_03155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7846"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="47812" checksum="399C062D7550871C" modified="2015-06-24" version="1">MTPHVTGATVKAADRAHVFHSWSAQALIDPLAVAGAEGSYFWDYDGNRFLDFSSQLVNTNIGHQHPKVVAAIQEQAARLCTLAPGFAVDVRSEAARLIAERTPGDLDKIFFTNGGAEAVENAVRMARLHTGRQKVLSAYRSYHGATAAAINLTGDPRRWPSDTASAGVVHFWGPFLYRSPFHATTEAEECERALAHLADTLAFEGPQSVAAVILESVPGTAGIMTPPPGYLAGVRELCDRYGIVFILDEVMSGFGRTGKWFAAEHWDVTPDLITFAKGVNSGYVPLGGVAISGAIAETFATRPYPGGLTYSGHPLACAAAVATINAMAEEGIVENAARIGTEIIGPGLAEIAARHPSVGEVRGLGTFWAVELVRDKETREPLVPYNAAGADNAPMAEFAAACKASGLWPFVNMNRTHVVPPCNVTDAEAKEGLALLDEALTVADRHTTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZZ8</accession>
    <name>A0A0F4JZZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">VR44_00330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812332.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39942">
        <property type="protein sequence ID" value="KJY39942"/>
        <property type="gene ID" value="VR44_00330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.64"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="11206" checksum="131D2AB502DFFDDE" modified="2015-06-24" version="1">MKIKKGDLVQVITGKDKGKQGKVIAAFPTESRVLVEGVNRVKKHTKAGQNQAGGIVITEAPVHVSNVQLVVEKDGKKVVTRVGYRFDDEGNKIRVAKRTGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K036</accession>
    <name>A0A0F4K036_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000008">
        <property type="protein sequence ID" value="KJY39775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39775">
        <property type="protein sequence ID" value="KJY39775"/>
        <property type="gene ID" value="VR44_00540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.108"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471000" evidence="2">
        <location>
            <begin position="45"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="135"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="35056" checksum="213F213051FD238A" modified="2015-06-24" version="1">MQLVRQKGNPTQFGHRSAARPRGRYGVAAAALLVAALGTGCGAADPGTPVKGKPGQAAAEAGSGAAGALANSAEQLKAAQAARAAMAKKWGLAKTPLMAPAGPKTKPEITTREGFEVEGQDELPPVFTTVPTEDKVVFLTVDDGAEKDPEFIRMMQELKIPYTAFLSDYLVRDNYPYFKEMQAAGVTLNNHTLNHRYMPGLNYEQQREEICGQQDTIQKQFGKRPQLFRPPYGNYNQDTLRAAKSCGIKAVPLWNAEAFPNRMDYREWDRDLHPGDIILTHFRGREDWKGTMPDMIRHVMKTVTDKGYAVARLEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0I2</accession>
    <name>A0A0F4K0I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ORF">VR44_01710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945530.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000076_gene7447"/>
    <dbReference type="EnsemblBacteria" id="KJY39423">
        <property type="protein sequence ID" value="KJY39423"/>
        <property type="gene ID" value="VR44_01710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5744"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY39423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="614" mass="66052" checksum="B3492F403EA30B89" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0M6</accession>
    <name>A0A0F4K0M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_01620</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="JZWV01000020">
        <property type="protein sequence ID" value="KJY39478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945512.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6524"/>
    <dbReference type="EnsemblBacteria" id="KJY39478">
        <property type="protein sequence ID" value="KJY39478"/>
        <property type="gene ID" value="VR44_01620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5682"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY39478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="36607" checksum="6BF5E7659AE77959" modified="2015-06-24" version="1">MPIATPEVYNEMLDRAKAGKFAYPAINVTSTQTLHAALRGFAEAESDGIIQISTGGAEFLGGQYNKDMVTGAVALAEFAHVVAAKYDITVALHTDHCPKDKLDGYVRPLLDISAERVAKGLNPLFQSHMWDGSAETLADNLAIGQELLAKAAAAKIILEVEITPTGGEEDGVSHEINDELYTTVEDAIRTAEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKDLQQGVGEKYGKSNPFDFVFHGGSGSTEQEIATALENGVVKMNLDTDTQYAFTRPVADHMFRNYDGVLKVDGEVGKKSTYDPRTWGKLAEASMAKRVVQACADLRSTGTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Z1</accession>
    <name>A0A0F4K0Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945256.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40060">
        <property type="protein sequence ID" value="KJY40060"/>
        <property type="gene ID" value="VR44_00060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.12"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="2">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY40060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18893" checksum="4B5833DE83F5DBB5" modified="2015-06-24" version="1">MNETEQLLEQVTARARDAVREHGKPRPAPLADGETDRTESALGFALPPLLAALYTRVGDGGFGPEYGLLPLRQAIAAYEAGRSSDWGWPEGVLPIADLGCAMSACVDCRSETARMLLFEPNPGDPDLAWYHLSPSLADWLRDWLDGTGWFREEWDEDETDAGPWAEFSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1C6</accession>
    <name>A0A0F4K1C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_02315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945646.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2421"/>
    <dbReference type="EnsemblBacteria" id="KJY39021">
        <property type="protein sequence ID" value="KJY39021"/>
        <property type="gene ID" value="VR44_02315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6753"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="360" mass="39874" checksum="D4869B038ACF8668" modified="2015-06-24" version="1">MFSNLRRAVRRGYRRAVDLSHPARSPLGSAVVNCVVYQDGIRQDGCAEVEEALRRVRKTGEGFVWIGLHEPSQLELAGLAELLGLHPLAVEDAVHAHQRPKVERYDDTLFAVFKTVRYVEHEELTATSEVVETGELMAFVGEDFVITIRHGGHGTLGPVREALEAEPEQLAKGPAAVLHAMADHVVDDYVAVTDAVQSDMDAVETAVFSEHGGRGDAGRIYQLKRELLELRRAVAPLGRPLEHLATQPIPVIPPEVRAYFRDVADHLTRATEQIAAYDGLLDSILQAHLAQVTVAQNEDMRKITAWAAIVAVPTMVCGVYGMNFDHMPELHWTYGYPLVLAVMAVACYVIHRGFRRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2V3</accession>
    <name>A0A0F4K2V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_01560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4197"/>
    <dbReference type="EnsemblBacteria" id="KJY39511">
        <property type="protein sequence ID" value="KJY39511"/>
        <property type="gene ID" value="VR44_01560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4745"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="117"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34031" checksum="79D840E784F38530" modified="2015-06-24" version="1">MTTTAPGAAPEAAPAGAQAKDVPPGSSPWQLARRELRRRPAVRVSLCVVLLFVLMALTAPWLGALGGWSPEEFDKAAVDPYLAGQPLGSFGGISPEHWLGVEPVTGRDLFARVVHGAQVSLLIAFAATAIVVLTGTAAGIAAGYFGGRTDAVLSRLMDLTMSFPSLIFMIAMLSVAKDVNRIVLMTSVIGLFGWPGVARVVRGQTLSLKHREYVDAARVGGSGAWRILTRDILPGVSGPVIAYTTLLIPGMISTEAALSYLGVGVRPPTPSWGQMIAESVAFYETDPMYFVIPSVFLFLAVLAFTLLGDALRDILDPRGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1H7</accession>
    <name>A0A0F4I1H7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001827">
        <property type="protein sequence ID" value="KJY15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15880">
        <property type="protein sequence ID" value="KJY15880"/>
        <property type="gene ID" value="VR44_40715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7082"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8602" checksum="9142EBE660BAEF30" modified="2015-06-24" version="1" fragment="single">MDPQQRLLLETTWEAFERAGIDPATLKGSRSGVFIGSNGQDYASGLRRAPEGVEGYLLTGRAASVVSGRLAYTFGLEGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6L2</accession>
    <name>A0A0F4I6L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001692">
        <property type="protein sequence ID" value="KJY17093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17093">
        <property type="protein sequence ID" value="KJY17093"/>
        <property type="gene ID" value="VR44_40145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20576" checksum="DBEACB2772DFA2BE" modified="2015-06-24" version="1" fragment="single">AFHSPLMDPMLDEFRAAVESVPFAPPALPVVSTLTGGPVGADEFCSPRYWVRHVREAVRFADAVASLAAEGVGTFLEVGPGGVLTAQAQHLLDDTRVLVPLLRTDRHEHLAVTTALARLHVHGTPVDWAAVHAGRGARRIDLPTYAFQRQDYWLRPAAPAGRRSVIEDWQYEVTWKRLPAPATGPAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8U2</accession>
    <name>A0A0F4I8U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_39725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001628">
        <property type="protein sequence ID" value="KJY18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18084">
        <property type="protein sequence ID" value="KJY18084"/>
        <property type="gene ID" value="VR44_39725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6127"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20151" checksum="AA9AD968A352D653" modified="2015-06-24" version="1" fragment="single">PLPAHPALTAAAGRASAPATVVDVAGGNGELLRHVLTAHPGLHGVLLERPHAVATARRLLDAAGCGARCEYRAGDFADVPPGGDVYVLARVLHDWDDDRCREILGHCARAMPGHADLLIVERLLPADGSPSPATAWDLHMLCNVGGRERREDHYARLLADAGLHLHDRTPLPLGAHVLHARKRPTTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ID36</accession>
    <name>A0A0F4ID36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001530">
        <property type="protein sequence ID" value="KJY19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19930">
        <property type="protein sequence ID" value="KJY19930"/>
        <property type="gene ID" value="VR44_38920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12440" checksum="3C047681E7DA7DB8" modified="2015-06-24" version="1" fragment="single">MRSPEDLWRLVAEGGDAVGGFPVDRGWALDGLFHPDPDHAGTSYAREGGFLYEAGEFDAAFFGISPREALAMDPQQRLLLETSWEVFERAGIDPGSLKGSRTGVFAGVMYHDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFH1</accession>
    <name>A0A0F4IFH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001553">
        <property type="protein sequence ID" value="KJY19406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19406">
        <property type="protein sequence ID" value="KJY19406"/>
        <property type="gene ID" value="VR44_39130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5589"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="30035" checksum="41F0441CE94B36FD" modified="2015-06-24" version="1">MALTINAVTIDNEDDINAVYRYDGFGTSWTQIQGPVTVTGTFGGGWGLLIGSADGDTADQEFSYNGNPFDWQFISAPAASFTVTDDTVYKKSADGNAVLQFDGFDDDARPLWSQIGNSVFEIVGGRFGLMAQMPNSIDGHAFLYSGTPGEWQHIGDKGGAYAVSSDTVYRTEPHGRTVFEYDGVGTSWTDVGSPPGGTTNIQAGGFGLIGSSFDAHGLFRYRGSPGSWERIGDFTISYAVTDDTVYRVGANGTVFQYDGSGMSWTSIGRPDRVFKLVAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFX7</accession>
    <name>A0A0F4IFX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001496">
        <property type="protein sequence ID" value="KJY20574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20574">
        <property type="protein sequence ID" value="KJY20574"/>
        <property type="gene ID" value="VR44_38640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5402"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY20574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="12778" checksum="D2326D8C056772A1" modified="2015-06-24" version="1" fragment="single">LTAVELRNRLGAATGLKLPTTMVFDHPTPSALTDGLLHALLPAGAADRATEEGGPDEDRIRRALATVPLARLREAGLMDALLALTGGPADTAPDPDHADPDTGSAIADMDLDHLIELALGDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGM3</accession>
    <name>A0A0F4IGM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001536">
        <property type="protein sequence ID" value="KJY19806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952421.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19806">
        <property type="protein sequence ID" value="KJY19806"/>
        <property type="gene ID" value="VR44_38965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5510"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY19806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="40345" checksum="5CC8D7C43BE0DA9B" modified="2015-06-24" version="1" fragment="single">RTRTAGQGATVRESWRRIVPQALVVAFLAGGTTAFVAADKSVHLTVDGEPRTLHTFAGNVEDLLDAEGLGVGPHDLVAPARDSSLEDGEEVVVRYGRPLRLTLDGTSRQMWTTARTVDAALRQLGVRVEGAYLSAPRTAPVPRAGLALSVRTERGVTFMADGRERTIRTNAATVQEALDQAGITLRGEDTTSVPPDSFPRDGQTITVLRITGTREVREERIPYATERVEDDTLFAGTEVVERAGRPGARRVTYGLRTVNGVRQPARKIAEEVVREPVSQLVKVGTKPLPTSVAGADHLDWGALAQCESGGRPSATDASGTYGGLYQFDVTTWQALGGSGRPQDAPAGEQTFRAKKLYVQRGASPWPHCGRRLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHR6</accession>
    <name>A0A0F4IHR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001450">
        <property type="protein sequence ID" value="KJY21570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001450.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene582"/>
    <dbReference type="EnsemblBacteria" id="KJY21570">
        <property type="protein sequence ID" value="KJY21570"/>
        <property type="gene ID" value="VR44_38235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5256"/>
    <dbReference type="eggNOG" id="ENOG5032S76">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="501" mass="54362" checksum="741593273C580152" modified="2015-06-24" version="1">MTLPAPAKTLPSPAPGPAADEGLARRLRALACTAPLHDLDVRKANLAGEYGVYAMAEVALSAIDLVTLNMDFDTGADHEQIVARLLPRVAAQTPHRPAAEHERVARWVLENLINVGSVDRGFRAIYGTFGADGVYVRRDYDFKLIEEVPGHGGAVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLISRGRLADAQLAAEQARYRTVQYAETLRRTLDATRRNVRAVDWLQAVPDMIAEALDHVADRYRHENAILTNIRKARDEAEDPENKRRAAELVDIVKDCIRRHTQLQSRLLDAGPLFRAEQDRQAFAAPAARSGIDLYGQLVAPVLPLPVAHATRVTDAFFAAGTGLRTPVSVRVADLVEILLTPPVEREHLGAEMPEPDLIATPDDSRFSEEQLAAATRLLDLPHDAPRRLSGLLAQARREDPDLPYLVALLAVHAASPAVGTAYRQGEERLLFAVDDGTPLEDPEFGGADLIVGTALLDAAGMAADRAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJ10</accession>
    <name>A0A0F4IJ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001435">
        <property type="protein sequence ID" value="KJY22010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952258.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001435.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22010">
        <property type="protein sequence ID" value="KJY22010"/>
        <property type="gene ID" value="VR44_38090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469849" evidence="4">
        <location>
            <begin position="35"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY22010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24127" checksum="42E742654A5AFA9A" modified="2015-06-24" version="1" fragment="single">GTPSASAPAAGAKAANLTVLAASSLTDVFNAAGAAYEKSHPGTKVKFSYAGSQELAAQVKQGSPADALVTADTKTMDGVKAEANDPTVIAKNRLVIATGKGNPFKIAQLKDLADSKIKVVLAAPEVPVGRYSKQILDAQKIEVKPVSQEPNVRAVLSKVELGEADAGLVYKTDSAKSGDKVVSVDIPDEQNVVASYPAATLKQSKNAEAAAAFVAWLSSPEAQKILQDAGFQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJU2</accession>
    <name>A0A0F4IJU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001438">
        <property type="protein sequence ID" value="KJY21939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952263.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21939">
        <property type="protein sequence ID" value="KJY21939"/>
        <property type="gene ID" value="VR44_38115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5227"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="20418" checksum="B4A24A5A491B803A" modified="2015-06-24" version="1">MRDAEFFRDWLEAAAAAVEREADRLTELDSPIGDADHGTNLLRGFTAVRTALAGADPSTAPGALLQLAGRTLISTVGGASGPLYGTLLRRTGKELGEDPEVSDTALHRALEAGVGAVAQLGGAAPGDKTMLDALTPGVAALGTSYRAARDAAEAGALATVPILARKGRASYLGERSIGHQDPGATSSALLLTALADTAEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ24</accession>
    <name>A0A0F4IQ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001364">
        <property type="protein sequence ID" value="KJY23779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23779">
        <property type="protein sequence ID" value="KJY23779"/>
        <property type="gene ID" value="VR44_37290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7635" checksum="A90D22087CA980E5" modified="2015-06-24" version="1" fragment="single">MDRNLGDCGPAHGPTSREGPCGGLPLDAVPPVDPPGDGLRDDLGHPGPGHPAAVRMRNPPGPAPFPVTPGRGHVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ66</accession>
    <name>A0A0F4IQ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001353">
        <property type="protein sequence ID" value="KJY23819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23819">
        <property type="protein sequence ID" value="KJY23819"/>
        <property type="gene ID" value="VR44_37160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4822"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="488" mass="52417" checksum="2127D96F058F2F1D" modified="2015-06-24" version="1" fragment="single">HGFRDDCPFYPAGQHVELLPGTPQMRCLTGRHPVLEPELASAAGWIAQDPERSRRLLDQGVHSLIVVPLLARGVLLGIASFYRSQDPAPFGDDDTRLAQELAARAALCIDNARRYTREHNLALALQRSLLPRGLPEQGAVEVAHRYLPAESGVGGDWFDVIPLSGTRVALLVGDVVGHGLHAAATMGRLRTAARTFAELELAPDELLTHLDNLLVRLDREEGGDEAPGSTGVVGATCLYVVYDPTTRQCTMARAGHLPPALVHPDGRVTFPDVPAGPPLGLGGLPFETAGIELPEDSTLVLYTDGLVEDRHGDIDVALDRLRAVLAHPDRAPEETCRAVMDAMAPEHPGDDIALLVARAHTLPAGRIAAWDLPADPAKVCDIRAAATRRLAEWGLEELAFAAELLLSELVTNAIRYGGEPIQVRLIHDRTLICEVSDGGSSAPHLRRAASTDEGGRGLFLVAQLAQSWGTRYTPRGKVIWAECALDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQX7</accession>
    <name>A0A0F4IQX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001300">
        <property type="protein sequence ID" value="KJY24069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951940.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001300.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24069">
        <property type="protein sequence ID" value="KJY24069"/>
        <property type="gene ID" value="VR44_36395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4531"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11533">
        <property type="entry name" value="NTP-PPase_Af0060_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044548">
        <property type="entry name" value="AF0060_NTP-PPase_MazG-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14167" checksum="CE53F0191DDFC8EE" modified="2015-06-24" version="1">MTEQLRGGDGPVEAAGSADWETVRALAARFEAAAAERGVVPPQSHVLQVLKIGEEFGEAAQAVIGATGSNPRKGRSHSWEDVHDEVCDVIITGMVALARMRPDAAAYFSSQLTLKAGRFLPVPPPAPPLREDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR60</accession>
    <name>A0A0F4IR60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001322">
        <property type="protein sequence ID" value="KJY23958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23958">
        <property type="protein sequence ID" value="KJY23958"/>
        <property type="gene ID" value="VR44_36730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4655"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="15992" checksum="7A36387F6960D626" modified="2015-06-24" version="1" fragment="single">FNVYTDPEAADIVFRSGVPVTMCGLNVTHQALATPEVVARFAGLDTELGTVCAELLTFFASTYLRLWGMPHPPLHDPVAVARVIDPAIVDCADANVAVELRGTHTRGATVVDPHGYLGRPANARVAVGLDREAFWDRMVAAVTALGARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR95</accession>
    <name>A0A0F4IR95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4439 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001215">
        <property type="protein sequence ID" value="KJY24512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951707.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001215.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24512">
        <property type="protein sequence ID" value="KJY24512"/>
        <property type="gene ID" value="VR44_35145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4107"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="1">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16263" checksum="91889EE9BB516F71" modified="2015-06-24" version="1">MNPAVKPSPSPGGRALEAAQAALAAEHAAAYGYGVIGARIDPARATEAREAYGQHLSRRDRLTRTVRELGGAPRPSEAAYALPFEVRSGDDAVRLAADIEDRVAGAYSDLVRAADGQLRRDAADALSAAAVRAARWRGVGVAFPGLTERAEGGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRB6</accession>
    <name>A0A0F4IRB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_36575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001311">
        <property type="protein sequence ID" value="KJY24013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24013">
        <property type="protein sequence ID" value="KJY24013"/>
        <property type="gene ID" value="VR44_36575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="41127" checksum="238B2BD5C4227999" modified="2015-06-24" version="1" fragment="single">MTLTGSRGNSVPQDEPRKDVVIAGRYRLGKRLGRGGMGTVWRASDELLGRAVAVKELHVGEGKEAAGALREARTVAQIKHPHVVVVHDVVEDDGRHYIVMELVEGGSLADRLGADGPLDTGETARVGLALLGALGAAHERGVLHRDVKPANVLMEAGTGRVVLTDFGIARLAGSTTISETGAFVGSPEYTSPERMQGAAAGPASDLWSLGALLCAALTGESPFHRDSLGGVLHAVVQDEIRPPAQAGPLAPLVRGLLERDTERRLGAAEAQRMLSAYVTTGSLPLLGSAPAPAPGRPAVPAPVGWSPTERATAQTGPAAAPEPRAGLRAGLVAALVVVAVIGAVAVTSLLSGPAGGGRDTAQDDRPGRAPATATSAPRPPAASPVTATATATATTTVTAPPPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRV2</accession>
    <name>A0A0F4IRV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001270">
        <property type="protein sequence ID" value="KJY24203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951875.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001270.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24203">
        <property type="protein sequence ID" value="KJY24203"/>
        <property type="gene ID" value="VR44_36055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4369"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14684" checksum="A0DED9443427320A" modified="2015-06-24" version="1">MATVELTKENFDRTVSENPFVLIDFWAGWCRPCLAFAPVYEKASEANPDLVFAKVDTEAQQELAAAFQITSIPTLMIVRDQVAIFAQPGALPEAALTDLIGQARALDMDEVRQKIAAQQKTASGEGQDGTPGTPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT94</accession>
    <name>A0A0F4IT94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">VR44_34595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001182">
        <property type="protein sequence ID" value="KJY24688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24688">
        <property type="protein sequence ID" value="KJY24688"/>
        <property type="gene ID" value="VR44_34595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3904"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="69"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="22827" checksum="58FB8B383FD70FAA" modified="2015-06-24" version="1">MRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAASARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVVRFLKQGDKVKITIMFRGREQSRPELGYRLLQRLAEDVQELGFIESNPKQDGRNMIMVLGPHKKKTEAMAEAREAQAARKAERQGGAAAEAAPAEAAEVESTEVDADGSADANAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITK3</accession>
    <name>A0A0F4ITK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001313">
        <property type="protein sequence ID" value="KJY24006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24006">
        <property type="protein sequence ID" value="KJY24006"/>
        <property type="gene ID" value="VR44_36605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15750" checksum="E8613EBA44485569" modified="2015-06-24" version="1" fragment="single">MREFTVPPVVGGSPAGGLADVVFEHAGQDPHRVALGRKTGGVWRDVTSGELAGEVLALAKGLLAQGVRFGDRIAVMARTRYEWTLFDFALWAIGAQPVPVYPTSSAEQVHWILYDSSCAGCVVEDEDQAMTVGSVIERLPGLRLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU51</accession>
    <name>A0A0F4IU51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase A24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_36000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001268">
        <property type="protein sequence ID" value="KJY24216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951866.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001268.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24216">
        <property type="protein sequence ID" value="KJY24216"/>
        <property type="gene ID" value="VR44_36000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4358"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="4">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="23643" checksum="DA2DC04B1CC0D6A5" modified="2015-06-24" version="1">MGVVVIILAAAYGAATGLGLPRAAYRLAVEPGEPWRTHCPDGHPLQGWFGRTPCGRAPHGPGGAGWAPAVVSAAVCAGLAGAGGTRPEAGVFVAVAPVLVLLGIVDLAVHRLPDVLTLPLAALTAALLGVAALLPRAAGTWRGALLGGAALGAAYLVLFLINPAGMGLGDVKLALPLGVALGWYGWGVWAAGAFLGLLYGAVYGLAALLTSRATRGTGFAFGPFMAAGALTGVLLGGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUZ3</accession>
    <name>A0A0F4IUZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001219">
        <property type="protein sequence ID" value="KJY24486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951717.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24486">
        <property type="protein sequence ID" value="KJY24486"/>
        <property type="gene ID" value="VR44_35200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4121"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="22381" checksum="17F5DCD8097CA2B2" modified="2015-06-24" version="1" fragment="single">RAGKGPFRNVTPGGLHVHHCVPGVILMTVGGFTAIAGGRTGWGSWVAAVLFGMGTGLVLDEFALILHLSDVYWSKEGTLSVEVVLMTSALAGLLLCGFLPLGVDGLTEDQLENRLFLAVTVLFNLLLAVVALFKGKPRLAVFGMVVPLIALIAAVRLARPASPWARRFYGGRPRARARTLRRAYRHDRRWSGLERRIGYLIGGAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV56</accession>
    <name>A0A0F4IV56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001013">
        <property type="protein sequence ID" value="KJY25902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950999.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25902">
        <property type="protein sequence ID" value="KJY25902"/>
        <property type="gene ID" value="VR44_31310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2750"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="43329" checksum="B680410436639863" modified="2015-06-24" version="1">MDPAGGCPHALNARLRAEGTVAEVVLPGGVPGAVVLGHEALKEFLAHPDAAKDARHFPGLHDGTVPADWPLRVFANAQGMHTADGADHRRLRSLVGNAFTARQVERLRPRVEELADELLDGLARAAEGSADGVADLRTHFALPLPMGVICELLGVDPRHRGRLHELSHTVIISTDIPPAEVMAAVRELVELIATIAAARRADPGEDLTSALIAARDGDGDRLSEAELIGTMRLMLVAGHETTLNLISNAVRALCTHRDQLDLVLDGRASWSDVVDETLRWDGPVSWFPFRYPTRDLTVDGTLIPRGTPVLAGYTAAGRDPAVHGPDADRFDVTRPGAARNLSFGHGAHYCVGAPLARLEATIALERLFTRFPGLDLAVPETELPHQRSFIGNSVEALPVRLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVS5</accession>
    <name>A0A0F4IVS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001057">
        <property type="protein sequence ID" value="KJY25558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25558">
        <property type="protein sequence ID" value="KJY25558"/>
        <property type="gene ID" value="VR44_32165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3152"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6512" checksum="B4831766BD805CE5" modified="2015-06-24" version="1">MGGRKVTAHVFGVDADLGRAFDPGDVSALLRRAGFEDVDLSEEGPIRWEGGGPQVWTADNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWG6</accession>
    <name>A0A0F4IWG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000948">
        <property type="protein sequence ID" value="KJY26372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950803.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000948.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26372">
        <property type="protein sequence ID" value="KJY26372"/>
        <property type="gene ID" value="VR44_30230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2453"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="242"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="478" mass="49356" checksum="4AE883DB3FFA681D" modified="2015-06-24" version="1">MTGPVLAVDQGTSGTKALVLCPERGVIGSASAPVRPRYLPDGRVEVDPRDLLRSVIDAGRAALAAAGEPAVAVGLANQGETVLAWDPANGEPLTDAIVWQDRRAAELCTELAPHADLLRERTGLPLDPYFAAPKMAWIRRHLTRRGVVTTSDAWLVHRLTGEFVTDAATAGRTQLLDLDTVAWSRPALEAFGLDAEPLPRVVDADTRVGTTTAFGPELPLTGLLVDQQAALLAQSVTTPGAAKCTYGTGAFLLAQTGPEPRRSSTGLVGCVAWRIAGRTSYCLDGQVYTAASAVRWLTDLGVISGAEDIDTVGASVPDSGGVTFVPALAGLAAPWWRGDLRGSVTGLGLGTTAGHLVHALCDGIAAQVAELADAAAADLGAPLTTLRVDGGLTRSALLMQAQADLLGIPVEVSALPDATALGVGAVARLGLDPSLTVRDAVPEWKPSAVYAPRAGADEAAERRARFRTAVAALLDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX36</accession>
    <name>A0A0F4IX36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000998">
        <property type="protein sequence ID" value="KJY26003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26003">
        <property type="protein sequence ID" value="KJY26003"/>
        <property type="gene ID" value="VR44_31060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2667"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469913" description="AMP-binding domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="51122" checksum="821194375554CC5A" modified="2015-06-24" version="1">MRISTADYLFSPSSAGLLGLTLPAVFAAAAEVAPDAVAASDGKRTWTWRQWQADSQALAAGLQRKGVGTGDVVAIRLPNDWRFLTAHIAVAAVGAVLLPLPPALEHSDVRAVLDRIEPVFTVDRESWAMLLADGTGEQPVPVAVRPDMPLMVLPSSGTTAARRKLCLHTHDAALSNGAAVAADGLVTEADVLLGALPFGGFTLQLIHLTLFTRARQALLPHWDLDAFLDVAARTGATVLYAAPAQLGDLVRRLDTRSGAGIALRWVRTGCASVPASLIGDLRRTTGARVIVQWSEVWAGTYTRLDDPDDAVSATIGTPVAGARVRVVDGELQLRGPSMFRGYLGEPELTRAAVTGDGWLRTGDRAEIGVDGRVRFLGRASEMIKVGGREFPAREVEDVLARFGRVAVVGRPDDRHGQYPCLVVDRADITLAEVTEVLRAAGLAEYKIPRELVAVETIPLAYGGKISRRLVTELLAARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY73</accession>
    <name>A0A0F4IY73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001044">
        <property type="protein sequence ID" value="KJY25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25626">
        <property type="protein sequence ID" value="KJY25626"/>
        <property type="gene ID" value="VR44_31995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3116"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="33" mass="3588" checksum="F40BDE876C4FADCF" modified="2015-06-24" version="1" fragment="single">IQSVVSVLRELDFADTPPAIAYRAEVEKNDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYP8</accession>
    <name>A0A0F4IYP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyaluronate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000866.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1142"/>
    <dbReference type="EnsemblBacteria" id="KJY27150">
        <property type="protein sequence ID" value="KJY27150"/>
        <property type="gene ID" value="VR44_28385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2002"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="41694" checksum="9449622F38F07248" modified="2015-06-24" version="1">MWDVVVVGAGPAGAMAAYGAATAGRRVLLLEKAELPRYKTCGGGIIGPSRDALPPGFVLPLKDRINAVTFSLDGKLTRTRRSKRMLFGLINRPEFDAALVAEAEKAGATLRTGTAVSRVEQHGASVPDRRTVAVVLADGETVLARAVVGADGSASRIGAHVGVEMDQVDLGLEAEIPVPATVAEDWKGRVLIDWGPLPGSYGWVFPKGDTLTVGVISAKGEGAATKRYLDDFIARLGLAGFEPAVSSGHLTRCRKPGSPLSRGRVLVAGDAAGLLEPWTREGISFALRSGRLAGEWAAKIAEAQDAVDARRQALNYAFAVKAGLGVEMSVGKRMLTVFESRPGLMHGALTGLRPAWNAFAGITRGSTNLADLVRTHPMARKALHLLDARLARSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYR8</accession>
    <name>A0A0F4IYR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000863">
        <property type="protein sequence ID" value="KJY27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950448.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000863.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27170">
        <property type="protein sequence ID" value="KJY27170"/>
        <property type="gene ID" value="VR44_28300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1904"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23970" checksum="FF113ED6BBBCE3F5" modified="2015-06-24" version="1">MTPRPEEAPVLLVPLYEHPADRPEAWERLIAGAGRLHSVVLNPASGPGEAPDERFAAVAARLKDAGVPVLGYTDTDYGRRPHADVVQDLLRHRDWYAADGAFLDQAASGPELLPHYGRLAVAARAAGARTLVLNHGVHPHPGYAALADLLVTFEGPWDAYRDGSATPPPWTADHPADRFCHLVYAVPPNAPAAALAAERHAAVHCAVPGTGAHPWGTLPHALETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYY8</accession>
    <name>A0A0F4IYY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000895">
        <property type="protein sequence ID" value="KJY26869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950590.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26869">
        <property type="protein sequence ID" value="KJY26869"/>
        <property type="gene ID" value="VR44_29055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2144"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="13414" checksum="356AA9DED9C5FC3C" modified="2015-06-24" version="1">MLSAVDHVQLAAPPGSEDKLRAYYQGVLGMTEISKPPVLAARGGCWFAAGAVQLHLGVEEDFRPARKAHPGLRVTGIEEYAGRLRERGADVVWDDNLPGHRRFYSHDPVGNRLEFLEPLPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ36</accession>
    <name>A0A0F4IZ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000851">
        <property type="protein sequence ID" value="KJY27290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950389.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000851.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27290">
        <property type="protein sequence ID" value="KJY27290"/>
        <property type="gene ID" value="VR44_27960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1841"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="17012" checksum="02EC35FCF49CEF2D" modified="2015-06-24" version="1">MVTTDWKTDLRQRGYRLTPQRQLVLEAVDALEHATPDEILAEVRKTASGVNISTVYRTLELLEELGLVSHAHLGHGAPTYHLADRHHHIHLVCRDCTEVIEADLDIAADFTAKLRTTFGFETDMKHFAIFGLCERCAAARRRDTPAPGQADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ42</accession>
    <name>A0A0F4IZ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001010">
        <property type="protein sequence ID" value="KJY25926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950985.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25926">
        <property type="protein sequence ID" value="KJY25926"/>
        <property type="gene ID" value="VR44_31230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2733"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26213" checksum="7DCF2BDB9C821C09" modified="2015-06-24" version="1">MVATAGLLLFGAGWVHALYEQPGAPVPPARSDSRPKAHAGSPEHAARGGRRPDALQGLPAAALSEDTRARIPAEARQLVLVTGKAKDSSESTAALYTRPAPGADWVRAAQWPARNGAKGWSTGREYGDLTSPQGVFSLSDAGGLLSAPPGTKLPYDRDSAFVATGRGVNGESLEGSFDYVVAIDYNRRQGVSPLDPVMPDGERRGGNIWLHVDHDGPSQGCVGLPKAAMRQLLQTLDPAAHPVIAMGPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ77</accession>
    <name>A0A0F4IZ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_27860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000847">
        <property type="protein sequence ID" value="KJY27335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27335">
        <property type="protein sequence ID" value="KJY27335"/>
        <property type="gene ID" value="VR44_27860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1810"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="945" mass="99375" checksum="194F75671DC025F9" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZG3</accession>
    <name>A0A0F4IZG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000877">
        <property type="protein sequence ID" value="KJY27029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950497.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000877.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27029">
        <property type="protein sequence ID" value="KJY27029"/>
        <property type="gene ID" value="VR44_28555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2040"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="423" mass="44007" checksum="B0049580572FFEEB" modified="2015-06-24" version="1">MNRRVVITGIGVVAPGGVGTKAYWARLTSGRTATRAISLFDASGFRSRIAAEADFDPLAHGFTPEEAARLDRAAQFALVSADEAVRDSGLDTAALDPTRTGVTLGSAVGCTTGLDNEYNAVSGGGSTWQVDHTLAVPHLFDYFVPSSMAAEVAWRVGAQGPVSMVSTGCTSGLDSIGHAVELIREGSADVMVTGATEAPISPITVACFDAIKATSPSNDHPETASRPFDATRNGFVLGEGSAILVLEELESARRRGAHVYAEIAGFASRGNAYHMTGLKAEGREMAEAITVALDEARLPATAVDYVNAHGSGTKQNDRHETAAFKRSLGSHAYEVPVSSIKSMIGHSLGAIGSLEVAASALAIEHNTVPPTANLHHPDPGCDLDYIPLTAREHRTDTVLSVGSGFGGFQSAMILTRPRLGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0L7</accession>
    <name>A0A0F4J0L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000836">
        <property type="protein sequence ID" value="KJY27419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950322.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000836.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27419">
        <property type="protein sequence ID" value="KJY27419"/>
        <property type="gene ID" value="VR44_27575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1750"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="144"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="311" mass="35276" checksum="B710E8DE2590C8FF" modified="2015-06-24" version="1" fragment="single">MSHRNARLTVHGRRILVERVLAGRPVAHVAAEMGISRPTAHKWVRRWRAEGDAGLHDRSSRPRTTPHRTVTVVEAKVCRLRSERKLGPARIGPILGMPASTVHRILVRHGLNRLAWLDRPTGQPIRRYECDRPGELVHVDIKKLGNIPDGGGWRTVGRAAGDRNRQATTTERKSCTPVIGYSYIHSAVDDHSRLAYSEVLPDERQHTAIAFWQRANAFFAGHGITVQRVLTDNGACYKSKLFTQTLTAAGIAHKKIRPYRPQTNGKVERFNRTLLDEWAYLRPYTSNTERTEALADFLHTYNHHRCHTALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2F9</accession>
    <name>A0A0F4J2F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000731">
        <property type="protein sequence ID" value="KJY28440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949909.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000731.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1619"/>
    <dbReference type="EnsemblBacteria" id="KJY28440">
        <property type="protein sequence ID" value="KJY28440"/>
        <property type="gene ID" value="VR44_25370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1170"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16172" checksum="09FB31A2649D7703" modified="2015-06-24" version="1">MPSHTFTVNGRSVTVDAPDNLPLLWVLRDLLGITGPKYGCGVDVCKACTSHLDGVDVRPCVVPVSACAGKAVTTIEGLADGDRLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKRTSEPTDEDIDAIANICRCGTYFRIREAIRSAAARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J328</accession>
    <name>A0A0F4J328_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_24920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949825.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7569"/>
    <dbReference type="EnsemblBacteria" id="KJY28640">
        <property type="protein sequence ID" value="KJY28640"/>
        <property type="gene ID" value="VR44_24920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.984"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="28180" checksum="BDF68775236FB5B6" modified="2015-06-24" version="1">MSGVSVAKDAQDAAGAADGLVVLSNVNKHFGALHVLQDIDLSIARGEVVVVIGPSGSGKSTLCRTINRLETIDSGTITLDGKELPSEGRELARLRADVGMVFQSFNLFAHKTVLQNVMLGQLKVRKKDQAAALEKAKSLLDRVGVGSQADKYPAQLSGGQQQRVAIARALAMEPKVMLFDEPTSALDPEMINEVLEVMQQLAREGMTMVVVTHEMGFARSAANRVVFMADGKIVEQATPEQFFSNPKSDRAKDFLSKILHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3I1</accession>
    <name>A0A0F4J3I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949982.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000747.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28258">
        <property type="protein sequence ID" value="KJY28258"/>
        <property type="gene ID" value="VR44_25760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24896" checksum="DCAF9431B7945F1D" modified="2015-06-24" version="1" fragment="single">MDTMRERFISVTSRLLDEDPRLALVLAEITMDGFRPAQRRHPDRVINVGIREQLLVGVGGGLALTGLRPVVHTFASFLVERPFEQVKLDFGHQDTGGVLVSSSASYDWPAGGYTHMAPGDVALLDTLDGWTVHVPGHPDEAEALLRHAYAAGDDRVYVRLSQMSNAAPRPGADGLRFQTVREGGAGVVLAVGPMLDGVLAATEGLDVTVLYAATVRPFDDAALRAATARASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3I2</accession>
    <name>A0A0F4J3I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000699">
        <property type="protein sequence ID" value="KJY28830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28830">
        <property type="protein sequence ID" value="KJY28830"/>
        <property type="gene ID" value="VR44_24400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.868"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27912" checksum="86C38695B6231FCC" modified="2015-06-24" version="1" fragment="single">YGAVELARQAAAAGRPGALRELAALRERTGDREGAEAMLREAADAGHTEAMMKLALLRKAAHDLEGAEEFARRAAAAGNAQGLAYLAWSQEDAGDKRGAEALAMRAHRAGHHEVLARLAHARELAGDRTGAEAVARQAAAAGELDPLNHLALGREQAGDRESAEAFAREAVAAGDGGETLDGVAVFRRRHSEEEAMALVREAARAGSHYALARLAKQLEEAGDTQGAEALHVEEANTGCIPRHDSKRRWPYGLDPDGSPTPCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Z1</accession>
    <name>A0A0F4J4Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_24235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="JZWV01000695">
        <property type="protein sequence ID" value="KJY28894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949700.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000695.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2969"/>
    <dbReference type="EnsemblBacteria" id="KJY28894">
        <property type="protein sequence ID" value="KJY28894"/>
        <property type="gene ID" value="VR44_24235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.827"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="220"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="419"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY28894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="628" mass="66832" checksum="3355E0BFEF1557DE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J671</accession>
    <name>A0A0F4J671_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000653">
        <property type="protein sequence ID" value="KJY29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949512.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000653.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29334">
        <property type="protein sequence ID" value="KJY29334"/>
        <property type="gene ID" value="VR44_23240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.588"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470192" evidence="2">
        <location>
            <begin position="20"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="842" mass="85446" checksum="268FE53EA2470CF8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L3</accession>
    <name>A0A0F4J6L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000719">
        <property type="protein sequence ID" value="KJY28556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28556">
        <property type="protein sequence ID" value="KJY28556"/>
        <property type="gene ID" value="VR44_25060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1102"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046080">
        <property type="entry name" value="DUF6098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19593">
        <property type="entry name" value="DUF6098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="18332" checksum="6A6DFAB323671B37" modified="2015-06-24" version="1">MHEDSLSTPMPQVGSLDELTGLVADRTGVYVRWSLGPAADLPSVSSRDDLTGIAMPGLSASALDVEPWWGERSLRLWVARRLYDYAHLPRTKDRRVRPWLLLGTEVGRGPDNEPLVTGVRPVGWVHQAVIDEATREIEDQPGGWGPLDRTPRRWHTRRRPGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6M9</accession>
    <name>A0A0F4J6M9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000717">
        <property type="protein sequence ID" value="KJY28576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949845.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000717.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28576">
        <property type="protein sequence ID" value="KJY28576"/>
        <property type="gene ID" value="VR44_25020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14325" checksum="861BB262BF388257" modified="2015-06-24" version="1">MITMGVQHSGGSVLVGISGDLDQDAGEALRRAFEGISGLERDVMVDVHGVGSMDVDGLLHLLDLHRRAELLGLRVLVVGWQPQPQQLMAQIAGIPGPGTACGERYALAGFRRLIEERAHRAHSLPEGQGWPACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7B0</accession>
    <name>A0A0F4J7B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949367.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29658">
        <property type="protein sequence ID" value="KJY29658"/>
        <property type="gene ID" value="VR44_22365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.362"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="46909" checksum="D35048E44FFFD8D1" modified="2015-06-24" version="1">MRAAIADGTLPVGSRLPASRVLAAELRVSRGLVTEAYQRLAETGQVAGRGRGGTVVVAAPPAAPAAPAGPAPRGGPIDALRALPCRIDLSPGVPDLTAFPRTAWLQAERRVLAGLTAADFGYGDPQGTPALRGAVAGWLARNRGIRADPGEVVVVAGVAQALGLLAQVLPGAGVRRVAVEDPGSLGARQQLEHGGLDTVGVPVDGAGLDVAALRASGAGAVLLTPAHQFPTGVVLDGERRRELLAWGAAGGLVLEDDYDAEHRYDRAPVPALRALAPESVAYAGSVSKLLAPALRLGWLLVPRRLHEEVVEAKRHADLGNPVLAQLVLARLMDSGELERHLRFVRRRHRRRRDAMLDAVARHLPGARVHGAAAGLHLMVTFDGADFPDTALAADALTLGVKAHPLSWHRISPGPPGLILGYAAGPAAEIEEGVSLLGRALRTRIRDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7K4</accession>
    <name>A0A0F4J7K4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">VR44_22145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949316.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5162"/>
    <dbReference type="EnsemblBacteria" id="KJY29738">
        <property type="protein sequence ID" value="KJY29738"/>
        <property type="gene ID" value="VR44_22145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.313"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY29738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22494" checksum="69335C025E3E2F5B" modified="2015-06-24" version="1">MQQLSDARLYLCTDARKRQGDLPEFLDAVLAGGVDIVQLRDKGMEAGEELEHLQVFAEAARRHGKLLAVNDRADVAHAIGSDVLHLGQGDIPVPAARAILGREVLIGRSCHAESEVDAAVAEPGVDYFCTGPCWPTPTKPGRHAPGLDLVRYAASLPQDRPWFAIGGIDAGNLDEVLDAGATRVVVVRAITEAVDPGAAAADLAKRVRARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Z9</accession>
    <name>A0A0F4J7Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the melC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949050.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000572.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30330">
        <property type="protein sequence ID" value="KJY30330"/>
        <property type="gene ID" value="VR44_20740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8866"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023199">
        <property type="entry name" value="GriE/MELC1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010928">
        <property type="entry name" value="MelC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06236">
        <property type="entry name" value="MelC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470219" evidence="3">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="13458" checksum="4158C4FA0501967A" modified="2015-06-24" version="1">MNKITRRQALGTTAGALTVLGIAGATAHAAATDSRAAATTPAGTVDEVYMGRRIQISPASGGGHHGGHHGGAGMPSVRIDGRELHVMQNADGTWISVVNHYETYADPTSLARAAVRELQGSQLAPMQMGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J884</accession>
    <name>A0A0F4J884_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000668">
        <property type="protein sequence ID" value="KJY29161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949588.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000668.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29161">
        <property type="protein sequence ID" value="KJY29161"/>
        <property type="gene ID" value="VR44_23630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.671"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="31726" checksum="F4AF1988C32914AB" modified="2015-06-24" version="1">MAAGRLLAVSDLHVVHAENRRLVEEQLLPGSPQDWLLVAGDVSETASEIEWALGLLRERFARVLWTPGNHDLWTPKDDEVSLRGEARYRYLVELCRSLDVLTPEDPYPVWAGAGGPVVVAPLFVHYDYSFRAPGLTKEQSLAAAHESGVVCTDEFLLHTDPYPDADSWCRARVAATEARLDEVDPALPTVLVNHYPLVREPTDVLRYPQFAQWCGTTLTADWHVRYRAAAVVYGHLHIPRTTYYDGVRFDEVSIGYPRERRLRGLPRGVLRDVLRPHEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8J8</accession>
    <name>A0A0F4J8J8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_21360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30073">
        <property type="protein sequence ID" value="KJY30073"/>
        <property type="gene ID" value="VR44_21360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="9">
        <location>
            <begin position="87"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="29827" checksum="1896C0C4542F1137" modified="2015-06-24" version="1" fragment="single">GGRPEQAARPHPYAAGPAPETAARPYPYPAAGGRLTPEEARAVASWDRDLDALEGELLRARAAVRDVELPGALSASQLLRLAADEQAFARDLARPMPKPPQPAARQGTRFHAWVESRFDALPLPHLDVLDPAADLPGTDQEIADAADLEALKAAFERSEYAERTPYRMEAPVQITLAGRVVRGRIDAVYRNPDGSYEVVDWKTGRTTQADPLQLAVYRLAWAEATGTPLDRVTAAFLHVRSGRVIRPRDLPGRERLEWILQGKTGADGAPQADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J955</accession>
    <name>A0A0F4J955_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948856.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000544.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30715">
        <property type="protein sequence ID" value="KJY30715"/>
        <property type="gene ID" value="VR44_19660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8546"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12632" checksum="D30E7C61D2DF91BD" modified="2015-06-24" version="1">MLKLQERLYRAYAEHRALLAALPWSVEPMAGWARGERYPHRGDVPDSPGWSTEEKETVNRIQSELGELAIAVGEHPYWATVPVEKRVAARMDLKKQTRPADEPAGEPATAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9I7</accession>
    <name>A0A0F4J9I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30454">
        <property type="protein sequence ID" value="KJY30454"/>
        <property type="gene ID" value="VR44_20395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8789"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21825" checksum="5D7D66BBFB0C5110" modified="2015-06-24" version="1">MRSRGQHGHGHEHGRGHGHCGPDRREEFRGRRAAFGPFGPGFGGGPFGGRGGRGGPRGRARRGDVRASILALLADRPMHGYEMIQEIGERSGGAWKPSPGSVYPTLQLLEDEGLISSASEGGKKLFTLTDSGRAEAESGPDAPWADAGRGFDFEAMHEVRAAGVGLMEAFGQVFKTGTPEQREKALAVVNDARKKLYLILADEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAI7</accession>
    <name>A0A0F4JAI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="11" type="ORF">VR44_18210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948581.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000042_gene5969"/>
    <dbReference type="EnsemblBacteria" id="KJY31387">
        <property type="protein sequence ID" value="KJY31387"/>
        <property type="gene ID" value="VR44_18210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8189"/>
    <dbReference type="eggNOG" id="COG1384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="42"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="327"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="579" mass="64251" checksum="244175EC94E32D9E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB61</accession>
    <name>A0A0F4JB61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949081.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30226">
        <property type="protein sequence ID" value="KJY30226"/>
        <property type="gene ID" value="VR44_20900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8910"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="23841" checksum="F9BB01061378BFA9" modified="2015-06-24" version="1">MKISELSRRTGVPVASIKYFRRQGLLPAGRATAATLAEYGEEHAERLRLIKALTTLGGLSIAATREVLGAVDQARTTEGALGAISYALPVPVASQGGAGEEEEAEAERAAGAEVAELLAALDWRAPAASPHVQGLTTALKELRRLDAQYAPGELAAYAGLAESVARLDLARAECLDDPVALAERAVIVFAICAPVFELLRRLAQEDQVRRRLADGDAGGPPSECGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBR6</accession>
    <name>A0A0F4JBR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide-8 synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948666.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31183">
        <property type="protein sequence ID" value="KJY31183"/>
        <property type="gene ID" value="VR44_18655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8340"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9589" checksum="FBF81D9F925274C8" modified="2015-06-24" version="1">MSETTAPAVLELENLRRTVADVLDVEETELTDEADFVNDLGVDSLMALEVMVVLEKKYGVKLGESELKEVTCLRKAYDLLDAKLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC36</accession>
    <name>A0A0F4JC36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000469">
        <property type="protein sequence ID" value="KJY31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948461.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31765">
        <property type="protein sequence ID" value="KJY31765"/>
        <property type="gene ID" value="VR44_17575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8078"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016628">
        <property type="entry name" value="ATPase_SAG2001_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015040">
        <property type="entry name" value="ATPase_SAG2001_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="856" mass="90749" checksum="B686BC64CC0376D7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCE5</accession>
    <name>A0A0F4JCE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_17235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000457">
        <property type="protein sequence ID" value="KJY31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948400.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000457.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000091_gene3542"/>
    <dbReference type="EnsemblBacteria" id="KJY31890">
        <property type="protein sequence ID" value="KJY31890"/>
        <property type="gene ID" value="VR44_17235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7980"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="28667" checksum="F619DC1663A0C2CC" modified="2015-06-24" version="1">MATTLAKAAEGSVAEQTHAARIEHVSKSFSGPAGSQLVLDDISLDVAPGEFVTLLGASGCGKSTLLNLVAGLDKPSAGSIETPGGRPALMFQEHALFPWLTAGKNIELALRLRGVAKADRRPEAERLLELVRLGGAYGKRVHELSGGMRQRVALARALAQDSRLLLMDEPFAALDAITRDVLHGELTRIWQETGLSVLFVTHNVREAVRLAQRVVLLSSRPGRVAKEWTVDIPQPRRIEDADVAELSLEITEHLRGEIRRHGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDT7</accession>
    <name>A0A0F4JDT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_18765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000514">
        <property type="protein sequence ID" value="KJY31141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948690.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4130"/>
    <dbReference type="EnsemblBacteria" id="KJY31141">
        <property type="protein sequence ID" value="KJY31141"/>
        <property type="gene ID" value="VR44_18765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8364"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="684" mass="74215" checksum="1EAB8920A866061D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEE0</accession>
    <name>A0A0F4JEE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31351">
        <property type="protein sequence ID" value="KJY31351"/>
        <property type="gene ID" value="VR44_18310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8210"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6243" checksum="F38338116D51E804" modified="2015-06-24" version="1">MSTTLKWFKSSYSGSNGGNCVEVATTPTTIHVRDSKVEDGPVLDLGPASWAALTGWVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG15</accession>
    <name>A0A0F4JG15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000395">
        <property type="protein sequence ID" value="KJY32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000395.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32744">
        <property type="protein sequence ID" value="KJY32744"/>
        <property type="gene ID" value="VR44_15245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7385"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="20369" checksum="71C795FB2E128642" modified="2015-06-24" version="1">MSELRTERLLLRGWRESDLAPWAAMNADPEVRRYFPGVLTREQADASAARFQAEIHRRGWGWWAVEVIDSGEFIGFTGLDAVEDVMPFTGVEAGWRLARSAWGHGYATEAARAALEFGFDTLALPEILAVTSVTNVPSQAVMRRIGMTRDRADDFDDPTMPLGPLRPSVVYRLPRGRYQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG39</accession>
    <name>A0A0F4JG39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">VR44_14370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947869.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33170">
        <property type="protein sequence ID" value="KJY33170"/>
        <property type="gene ID" value="VR44_14370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7223"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="20771" checksum="A0421209D190C5D1" modified="2015-06-24" version="1">MIAFVSGPVAALTPTLAVIEVGGVGMAVQCTPNTIAGLRVGEPARLATSLVVREDSLTLYGFADDDERQVFELLQTASGVGPRVAQAMLGVHSPDALRAAFAAGDAKALTAVPGIGPKGAQKLLLELKGKLGAPAAPVLGAQRAAASAPAPWAEQLTAALIGLGYAAREADDAVAAVTPQAEAAIAAGGSAPVPQLLRAALQSLNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGA6</accession>
    <name>A0A0F4JGA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948349.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31981">
        <property type="protein sequence ID" value="KJY31981"/>
        <property type="gene ID" value="VR44_16975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7925"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11453" checksum="733EE4C3A4734022" modified="2015-06-24" version="1">MPEARTPAQIEADIVRRREQLAETLDEIGVRMHPQTIIGDARARVSSAIDHTAGRAVACVNRLITDVKDGLRHEDGAPRFERIAPVALVAAGVVGLLVVSVRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGC2</accession>
    <name>A0A0F4JGC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000388">
        <property type="protein sequence ID" value="KJY32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32859">
        <property type="protein sequence ID" value="KJY32859"/>
        <property type="gene ID" value="VR44_15180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7456"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="31774" checksum="1EBAD1E4C3C978ED" modified="2015-06-24" version="1">MTSARLLPHERQAEARDPLVARLRLLAAEHDLPAYRWVCEHLDAMTAATRNDPAGVRRHTGEGLHLADRYGMLWARGINATTRAMLAAVEGRFSEAEERYAQADELFRRVGAHHANGPRTLGLWTIRFTQGRTADIERSVREVHEAVGAPVAVAHALLLARQGRLDEAREIRFPARPVTDHLYGVELDYRSELAVLHGDTATARLLAGHLLPLRDQFGGAAGAAYATRPLAHPLGDLYRLLGEEGAAADAYARAERVALAWNSPHHAAAARRAAAELAAARRRRRVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGF6</accession>
    <name>A0A0F4JGF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">VR44_14170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000365">
        <property type="protein sequence ID" value="KJY33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947835.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000365.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3366"/>
    <dbReference type="EnsemblBacteria" id="KJY33295">
        <property type="protein sequence ID" value="KJY33295"/>
        <property type="gene ID" value="VR44_14170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7180"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="40830" checksum="613D14D6F153AF83" modified="2015-06-24" version="1">MTTSTRGAAKAPAVLVLEDGRIFRGRAYGAVGETFGEAVFSTGMTGYQETLTDPSYHRQVVVMTAPHVGNTGVNDEDPESSRIWVSGYVVRDPARVPSNWRSQRSLDEELVKQGVVGISGVDTRALTRHLRERGAMRVGIFSGETIADDAALLAKVQAQPQMKGANLSAEVATKETYVVPAIGEKRFTVAAVDLGIKGMTPHRMAERGIEVHVLPATATVEDVYAVNPDGVFFSNGPGDPATADGPVAVMQGVLERKTPLFGICFGNQILGRALGFGTYKLKYGHRGINQPVQDRTTGKVEVTAHNHGFAVDAPLDKVSETPYGRAEVSHVCLNDNVVEGLQLLDQPAFSVQYHPEAAAGPHDAAYLFDRFVSLMEAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGG2</accession>
    <name>A0A0F4JGG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947976.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32904">
        <property type="protein sequence ID" value="KJY32904"/>
        <property type="gene ID" value="VR44_15010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7421"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="39954" checksum="EFAF13AC7A84204F" modified="2015-06-24" version="1">MRVRHLDRVPALVWDSVLPALLLLHVGTTYPARQLPVAAALTAALALPLLWRRRAPVAVFAAVVAAAFVQWLADVQLPADAALLVALYTAAAHTGRRGTLLAAAVVEGGAALACLRWATNGAFLAPFVALSATVVAAAVLGVNVRTGRAYLAAVRERAERLALHQEQQALLAVAEERARITREMHDIVTHNLSVMVALTDAAVHAQHRSPDRATAAMLQISETGRQALTDMRRSLGVLRADEPDAERHPLPGIAQLEALAGQMAAAGLPTGLRVRGGHAHVPASTQLTVYRLVQEALTNTLKHTPAGTRATVLVECSAGSVGVEVTDSGPRPALPTAAPSGHGIPGMRERAAAYGGTLRAGPLPGGGWGVRTRLMLGSAGTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGG8</accession>
    <name>A0A0F4JGG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">htpG</name>
        <name evidence="8" type="ORF">VR44_15175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000388">
        <property type="protein sequence ID" value="KJY32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948011.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000388.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000056_gene609"/>
    <dbReference type="EnsemblBacteria" id="KJY32858">
        <property type="protein sequence ID" value="KJY32858"/>
        <property type="gene ID" value="VR44_15175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7455"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="7">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="562"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="641" mass="71226" checksum="97BE1671E81D49D1" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGQ2</accession>
    <name>A0A0F4JGQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947814.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33405">
        <property type="protein sequence ID" value="KJY33405"/>
        <property type="gene ID" value="VR44_14025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7108"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16024" checksum="9F59BED9DB7C0B58" modified="2015-06-24" version="1">MEGWRPQPPPPPGWHRFTLLHRPAGECPPYEDPRYDRLRAEPPQGCVAEEVGGCFGLRCERPGARLLDAVAATCAEVREGYGLLMFDLGVEKVQEWAADGPDGWGAEIVGQLLLMAAERGPRLGYGVEDLAGFLCRAAGGAVPGDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGU8</accession>
    <name>A0A0F4JGU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000379">
        <property type="protein sequence ID" value="KJY32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947948.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000379.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32973">
        <property type="protein sequence ID" value="KJY32973"/>
        <property type="gene ID" value="VR44_14825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7362"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12491" checksum="D06C5D2FEC3BFC41" modified="2015-06-24" version="1">MRTLCASTLIGEFFVVGFAGLVAMKNPDLTQAEVWTVCGVTMLLSVLLCGMLSRRGAVELGWALQIGLIASGFVVPTMFFLGAVFAALWWCSVRYGRRIDAIKASWAARQAEADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGW9</accession>
    <name>A0A0F4JGW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000428">
        <property type="protein sequence ID" value="KJY32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32226">
        <property type="protein sequence ID" value="KJY32226"/>
        <property type="gene ID" value="VR44_16380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7733"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23666" checksum="035B13C3CEDEBE24" modified="2015-06-24" version="1" fragment="single">FDSPYARSKYEAELAVRKAIADGLDATVHRVGTLVGNTRTGTFLPDPSVNMMYQILRVILSCGLVPSAPGWGMDLTPVDYAADAILRLSRDPAHSGRTFHVSNPVSLPSTDLAVILRDLGYAVIPAAPQAVGEWLGRPGADATDANAHAFLAQFVKPVRTLVEYDAQATAQALGDLRCPRPDAALLRTLIGHGIETGFFPKSRLWDFATLLDNPNAFGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH45</accession>
    <name>A0A0F4JH45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33510">
        <property type="protein sequence ID" value="KJY33510"/>
        <property type="gene ID" value="VR44_13865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7052"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14647" checksum="48F6095D96377559" modified="2015-06-24" version="1">MPSRPLHGARRQPEEGLGARPATPPPESAAAAREHVRELLLLAGVSLDSVPAADALLVTSELVTNAIRHGHGVTAFRADIADGVLRLSVADANPLPPTARTGSAEHPGGYGWPLVQRLAERVDCTTRADGKTITTALRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHZ3</accession>
    <name>A0A0F4JHZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_15740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000405">
        <property type="protein sequence ID" value="KJY32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948116.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32576">
        <property type="protein sequence ID" value="KJY32576"/>
        <property type="gene ID" value="VR44_15740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7552"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="190"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="38080" checksum="25F8AC8B311A4ADB" modified="2015-06-24" version="1" fragment="single">ERELGRGGWIGTGWDAPAGAYGQQRLSLPGQVVWAEEYAAARAPGRVGHIGENLLAPTLLAYGTPGQQARFLPGIARGEELWCQGYSEPDAGSDLAGLRTAAVRDPADGRLRVTGQKIWTSLAHEADWCFVLARTEAGSRRHHGLSFLLVRMDQPGRVEVRPIRQMSGTAEFNEVYFDGAVAEEVVGGEGNGWTVAMGLLALERGVSTLVQQIGFAAELERVVKAYAASGAPDPVLRERLVRQWAELRTMRWNALRTLGEAGDAGDAGAPSVAKLLWGGWHRRLGELAVAVRGARATAGPGLWARGGPYELGLDEEQRLFLFTRADTIYGGSDEIQRNIIAERVLGLPKEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ61</accession>
    <name>A0A0F4JJ61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947432.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34387">
        <property type="protein sequence ID" value="KJY34387"/>
        <property type="gene ID" value="VR44_11990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6483"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="8773" checksum="DFFCF8D75C8FCAE0" modified="2015-06-24" version="1">MLITVTRSGGFAGGEEERALDTAGRRDAPQWEELAQRAVAPTADGYHYRITVDGRAVDLQDPYLSEDQRRLIRGVLGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK94</accession>
    <name>A0A0F4JK94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947801.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33391">
        <property type="protein sequence ID" value="KJY33391"/>
        <property type="gene ID" value="VR44_13975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7096"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="465" mass="49138" checksum="586C15710543CA61" modified="2015-06-24" version="1">MTERTENEAESGAGGGGADGAGADDGGAAARRREQHGWYFYDFACSVYSTSVLTVFLGPYLTAVAKAAADAEGYVHPLGIPVRAGSFFAYTVSLSVILAVLVMPLAGAAADRTGRKKPLLAAAAYTGAAATTGMFFLDGHRYLLGGFLLVVANASLAVSMVLYNAFLPQISTPDERDTVSSRGWAFGYTSGAFVLVLNLVLFQGHDSFGLSEGVAVRICLASAGLWWGAFAIIPLRRLRDRAVVREAGAAPAVSGWRQLVATLKDMRRYPLTLSFLLAYLVYNDGVQTVISQASVYGSEELQLEQSTLIVAVLLVQVLAVVGALAMGRLAVAYGAKRTILGSLAAWGLTLGAGYFLPARTPVWFFALAAMIGLVLGGSQALSRSLFSHLVPAGKEAEYFSAYEMSDRGLSWVGPLVFGLTYQVTGSYRDAIISLVVFFALGFALLARVPVRRAVEAAGNPVPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKA7</accession>
    <name>A0A0F4JKA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000306">
        <property type="protein sequence ID" value="KJY34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34203">
        <property type="protein sequence ID" value="KJY34203"/>
        <property type="gene ID" value="VR44_12380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14494" checksum="FF43661959CDC1EF" modified="2015-06-24" version="1" fragment="single">MEIHSTVGGGLAAHIRAHLSDLRDTEARVARVVLDKGAELVHLSVSDVAALAGTAPSSVVRACQRLGFRGYQELKIAAARQAPAPEPSRDRDPAARALADTVRAAREALDGVAVTVTPERLRTAAGLFDAAGRVLVVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL27</accession>
    <name>A0A0F4JL27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947383.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3721"/>
    <dbReference type="EnsemblBacteria" id="KJY34514">
        <property type="protein sequence ID" value="KJY34514"/>
        <property type="gene ID" value="VR44_11740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6315"/>
    <dbReference type="eggNOG" id="COG3195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18333" checksum="E9CC25C9134D5467" modified="2015-06-24" version="1">MTSSPTPGLTRFNALDDSAASAELHEVCASSAWGSKMLAQRPFATADALYAANEAAMAELTADDLGEAMGGHAPIGRPKPGDPTSAREQRGMAGASEELKNELLELNLAYQEKFGHVFLICATGATGEFMRDAVKVRIDNSAEQEREIARGELVKINRIRLTRLVELAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLU3</accession>
    <name>A0A0F4JLU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000265">
        <property type="protein sequence ID" value="KJY34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947329.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34738">
        <property type="protein sequence ID" value="KJY34738"/>
        <property type="gene ID" value="VR44_11435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6184"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="92"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="32144" checksum="22B9AFCA28E25C91" modified="2015-06-24" version="1">MDGWYVDDRCSNCDVARQLAPDLIGEVDGTSRFLRPPRDEAERRRVHAAVFACPTRSIRHTSGPPDRRLDPFPMALDGGVLLCGHNSQHTAGANSYLLLRPSGTAMMIDTPRWSPALAERYAASGPVTDVLLTHRDHAAHGRRYADRFGARLWIHEGDLDAAPDADEVIRGLEPVEIGEGVTAHPLPGHTAGSVLYLADDRYCFSGDSFYWSRTTGDLEVAESVTWYSIEELAAALARVAGLLRFEWVLPGHGDRRRLPVDEMSRRLGALAERTRLLRPRPIDFTAVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM21</accession>
    <name>A0A0F4JM21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947167.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35245">
        <property type="protein sequence ID" value="KJY35245"/>
        <property type="gene ID" value="VR44_10560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5856"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16236" checksum="2FB01C89E5CA896D" modified="2015-06-24" version="1">MRIAVDDLSGSEVAAFLAEHVAEMRSITPPESKHALDLEGLRRPGVTFWTVTDDDGSIVGCGALKALAAGHAEVKSMRTASARKRSGVASLLLGHLIGEARRMGYARLSLETGAAEFFAPARALYAKFGFEPCAPFADYKPDPLSVFLTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMR0</accession>
    <name>A0A0F4JMR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946977.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35652">
        <property type="protein sequence ID" value="KJY35652"/>
        <property type="gene ID" value="VR44_09555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5312"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24522" checksum="B947172B78D87367" modified="2015-06-24" version="1">MATGHHNVHPLPQTNQLRAMHTIIRDRRASRADFVFYSRRIIRLLLESALDQLPFDQHEAITPVGETYEGLRLGPQLCAVPVVRAGDSMLDELRQVIPDITVGKLLIQRDKTTKLPHLYYKNFPEDIADRHVLLLEPMLATGGSAKAAIEVLLDAGVEEGNIVFVNFLASPEGIEAVHAKYPLVKIVTSSIEQRLNENAFMIPGIGDFGDRYFGTTDSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN35</accession>
    <name>A0A0F4JN35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947200.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35163">
        <property type="protein sequence ID" value="KJY35163"/>
        <property type="gene ID" value="VR44_10725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5893"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="39767" checksum="FE1E5ADB2C2BD823" modified="2015-06-24" version="1">MRSACPVQPVPAGAGGRVDYLVTGYAEAREALTDPRLSKDTGAFFAGKGSRRRLHPAVARTMLASDPPRHTRLRRLVTGAFTTGAVRELRPFISRVTDELLDRWPAGEPFDFMAGLAVPLPVIVICELLGVPQADRSEVRRWSAELFAAAEPDVVDAASHALAGYMTDLVAARRSAPGSSLLDRLVAARDGADRLSEEELVSLAVLLLVAGHETTANALGNALLALLRHPAVPARLRQDPDAVPALLDELLRFDSAVSTATFRFTTQALTLGGTRIPAGAPVLVALGAANRDPSRFPDPDRLDPDRDAAAHLAFGHGIHRCVGAPLAMAELEIALRAVLTRFPGIRLAVPPGQLQWRRTRLVRGLAALPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNB4</accession>
    <name>A0A0F4JNB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947165.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35243">
        <property type="protein sequence ID" value="KJY35243"/>
        <property type="gene ID" value="VR44_10550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5854"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20649" checksum="01FE0EE6242560DB" modified="2015-06-24" version="1">MGTYLCCVDAGDWSDEDILRPAARLLDGELLGRGLPPCPPPASGSAPGGGTSFEEKMYRPMQSFEALCRSLPGGDECCEVLLGWDLLIPVDFEGDVTLPVSGPYSETTTVHSAYRVLATAQRLAVRLALPPQVPRNGGNLGLCIWFDGPAAARAAVTHPGAWAEDLDASFYTALYLRAAEHSIRRQCPMHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPK8</accession>
    <name>A0A0F4JPK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_08220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000167">
        <property type="protein sequence ID" value="KJY36307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946730.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000167.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2961"/>
    <dbReference type="EnsemblBacteria" id="KJY36307">
        <property type="protein sequence ID" value="KJY36307"/>
        <property type="gene ID" value="VR44_08220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4396"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="55"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="543" mass="58734" checksum="006CE7F7F10312E5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPX4</accession>
    <name>A0A0F4JPX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947270.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34961">
        <property type="protein sequence ID" value="KJY34961"/>
        <property type="gene ID" value="VR44_11115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6107"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27949" checksum="FC0FB06E347450B3" modified="2015-06-24" version="1">MERIRAVLIDIDGVLTVSWKALPGTVEAMERLRSAGLRLALVTNNTSRTRAVIAARLSGLGFPVTAGDVLTAPAATAAYLREHFPGARCLLLNSGDVREDLPGVTLVDGHGTDAEVEVDVIVLGGAGPEFGYEALNRVFRHLQRGARLVSMHRNLYWRTEGGLDLDTGAFLEGLEKASRTEAEVTGKPAPAFFASALAHLGADASETLMVGDDVESDVLAAQRSGITGVLVRTGKYLPETHRAASGTPDHVLDSFADLPGLLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQJ5</accession>
    <name>A0A0F4JQJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946784.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene938"/>
    <dbReference type="EnsemblBacteria" id="KJY36124">
        <property type="protein sequence ID" value="KJY36124"/>
        <property type="gene ID" value="VR44_08510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4765"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29047" checksum="D28403CA4C78BF0A" modified="2015-06-24" version="1">MSALAAAATTTSTGEAIQFWVLAVVAVIGALCTILMKKAVHSALCLAGTMIVLAVFYLANGAYFLGVVQVIVYTGAIMMLFLFVVMLVGVTAADSLKETIKGQRWLAALCGLGFGILLIAGLANAKLTHFNGLGRVNSAGHVEGLAQLIFTRYIFAFEITGALLITAAVGAMVLTHRERTERAATQRELSEKRVREGVQVPPLPAPGVYARHNAVDIAGLLPDGTPSELTVNKTLRARGQIRDVSTEALDDLKALEQRSAERLGRDSREEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQR6</accession>
    <name>A0A0F4JQR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000154">
        <property type="protein sequence ID" value="KJY36520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946653.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000154.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36520">
        <property type="protein sequence ID" value="KJY36520"/>
        <property type="gene ID" value="VR44_07805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4267"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="20732" checksum="7C436F180275E244" modified="2015-06-24" version="1">MEITYRRFERTEGELLVDFLSGETWPFHASPAVEPDQVRGWLADGVYEGEESRTFWVLADGSTVGLVRLMDLGDDTPLLDLRIRSGWRGRGIGRRSLEWATRYLFEEFPRVRRIEGTTRRDNAAMRRTFLRCGYVKEAHYRDGWPGAGGAVHDAVGYAVLRRDWEAGTVTAVAWDDEPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRT6</accession>
    <name>A0A0F4JRT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase_SAM-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000120">
        <property type="protein sequence ID" value="KJY37072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37072">
        <property type="protein sequence ID" value="KJY37072"/>
        <property type="gene ID" value="VR44_06615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase_SAM-like_N" evidence="3">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="15005" checksum="BEB2734C709CE0D9" modified="2015-06-24" version="1" fragment="single">MKRCRCGRDTYPSAEHGRGDRWQVRYNDPHGKPRRESFPDAEYDRAADRLAEVRTDLRRGTWVDPEAGKILAVKAAEEWLEWIEKKHGVENTVDTYTSHTKTHVIPFLGRRPAGSLRRTDSNAFVDELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRW0</accession>
    <name>A0A0F4JRW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_07745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000150">
        <property type="protein sequence ID" value="KJY36569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36569">
        <property type="protein sequence ID" value="KJY36569"/>
        <property type="gene ID" value="VR44_07745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4252"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="7"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="549" mass="53227" checksum="FCEED601951F3A6D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRX4</accession>
    <name>A0A0F4JRX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methlyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000156">
        <property type="protein sequence ID" value="KJY36503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1211"/>
    <dbReference type="EnsemblBacteria" id="KJY36503">
        <property type="protein sequence ID" value="KJY36503"/>
        <property type="gene ID" value="VR44_07905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4401"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="8937" checksum="E56EDECB7F8E7A8C" modified="2015-06-24" version="1" fragment="single">TLLRADVARLPLRDGALDAVFAAGLIAHLPDPAANLRELARVVRPGGRLALFHPIGRAALAARHGRELTPDDLRAEHNLGPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSA9</accession>
    <name>A0A0F4JSA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uroporphyrin-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_07600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene561"/>
    <dbReference type="EnsemblBacteria" id="KJY36643">
        <property type="protein sequence ID" value="KJY36643"/>
        <property type="gene ID" value="VR44_07600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3997"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="29878" checksum="CEFA532239E33F37" modified="2015-06-24" version="1" fragment="single">MTADQPRGPQTPSSAGVLVLAGTPIGDLADAPPRLAAELERADVIAAEDTRRLRRLTQGLGVHTTGRVLSYFEGNESARTPELVEALEQGRRVLLVTDAGMPSVSDPGYRLVAAAVEKDIKVTAVPGPSAVLTALALSGLPVDRFCFEGFLPRKAGERLGRLREVEGERRTLVYFEAPHRLDDTLAAMAEVFGAGRRAAVCRELTKTYEEVKRGGLGELAEWAAEGVRGEITIVVEGAPAAGPADLDDEELVRRVRVREEAGERRKEAIAAVAAEAGVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSD3</accession>
    <name>A0A0F4JSD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000193">
        <property type="protein sequence ID" value="KJY35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35861">
        <property type="protein sequence ID" value="KJY35861"/>
        <property type="gene ID" value="VR44_09005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4974"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13329" checksum="2E62E59826A4254C" modified="2015-06-24" version="1" fragment="single">PDTVGHEGHNPYRGHFCAHAVTTVPGTRVGTLLPGTHQVATHHHQAVDRLGAGWIVAARAADGTVEAIESTRYRFAVGVQWHPEMGADAPVVRALVAAAGSAEGTGPVRTAATSAVRSGPGRIFPTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSX4</accession>
    <name>A0A0F4JSX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000128">
        <property type="protein sequence ID" value="KJY36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946487.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000128.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36919">
        <property type="protein sequence ID" value="KJY36919"/>
        <property type="gene ID" value="VR44_06895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3463"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="37506" checksum="05F089E13B27CE7E" modified="2015-06-24" version="1">MREGSSRGVSGRRNGRPTLEEVAALAGVGRGTVSRVINGSPRVSEQAREAVARAVAELGYVPNQAARALAGSRTDAVALVIPETEARVFSEPYFLDLIRGVSAELAQADKQLLLTLVRTEPERRRFEQYLAAQRVDGVLLASVHGDDPLPDRLARLGLPVVMNGRRSEAEPIDYVDSDNTGAGRAAVAHLVGRGRARIATISGPADMYVARARLGGYRAGLAEAGITPDESLVATGDFTEEGGRLAMRALLERAPGLDAVFAASDVMAAGARGALREAGRRVPEDVALVGVDDSVVARLMDPPLTSVRQPIEEMGRTMTRLLLRKIADGPGAGPAAEEEQPRVLPTELVVRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTU6</accession>
    <name>A0A0F4JTU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="8" type="ORF">VR44_04965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000092">
        <property type="protein sequence ID" value="KJY37787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946127.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37787">
        <property type="protein sequence ID" value="KJY37787"/>
        <property type="gene ID" value="VR44_04965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1308"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="57" mass="6380" checksum="9AB3FA1C8E07DD40" modified="2015-06-24" version="1">MLRNGLEPWHLIIVLVVCLMLFGSKKLPDMARSLGKSARILKSEARAMRSENSQDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUB0</accession>
    <name>A0A0F4JUB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946288.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000108.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37353">
        <property type="protein sequence ID" value="KJY37353"/>
        <property type="gene ID" value="VR44_05850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1986"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17322" checksum="AAC37E0DB6B9132D" modified="2015-06-24" version="1">MPAKVADELRESSSGPEAGAIANSRCCWGGCSGLEQLAFTRFIDTGALDRHQRKLRAEFHRRRQVIRRQTEACLPGARLTGRDGGLQAYLQLPPHLDELALVRAAREQSVLVRGSRFYTLTDASRPPALVISYATVDCAGLTKSLQAIGAAYRQLAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVB9</accession>
    <name>A0A0F4JVB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946118.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37794">
        <property type="protein sequence ID" value="KJY37794"/>
        <property type="gene ID" value="VR44_04920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1071"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="13276" checksum="DBEAC9466865FDE0" modified="2015-06-24" version="1">MSDEQTRKVVEQFNQAFRLHDPGLLKDILAEDCRLENSGPAPDGSRHSGYDECLRFWSSIAGNENMAFEVEDVWTAGERAVCRWTLRWGSGPEDFVRGVNVHRLEGGLLAESFGYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVF0</accession>
    <name>A0A0F4JVF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946156.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37728">
        <property type="protein sequence ID" value="KJY37728"/>
        <property type="gene ID" value="VR44_05125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1340"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="21695" checksum="8AB492F049DBEB33" modified="2015-06-24" version="1">MAATAVTKQKKQQAEAGTRERLVRTASRLMQHGGYESTPVKQLVREAEATLGSLYHFFPGGKQELAVAAIGHGDGEFAQMLRAALDSDPDAARAIEATAGVLADALAASDWRDGCPVTATALESVGRLPELQEACARSFGHWQELVAAKLRASGIEEAEAADLAVTVIATLEGAEMTSQVTRSRTPLLLAGRHLSRLVGSYTPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWN5</accession>
    <name>A0A0F4JWN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_02845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000050">
        <property type="protein sequence ID" value="KJY38787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945744.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38787">
        <property type="protein sequence ID" value="KJY38787"/>
        <property type="gene ID" value="VR44_02845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="189"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="417" mass="44063" checksum="1FAF5D5A29B5CF39" modified="2015-06-24" version="1">MTGTASPPRPKRRVFADLTPLRTSAHYRRLWVGGTISWMGQAMTALAISLQVYEITGSSFSVGLVGLFSLVPLVVFGLYGGAIADTVDRRKLGLHSQIGLTVLSSGLAAAALLEYHRVWLLYTVVALQAVCGALNGPARSAMIPKLLPPEQLPAANALGSVTMTSGTMLGPVLGGLIVGWWGYQAAYLIDAVTFIAALYAMWRLPAMLPEGRTGRASVMDGLRFLGTRPNLRMNFFSDMAAMIFAQPKALFPAIAVLWYGGDAKTVGMLVAAPAVGALLGGVFSGWQGRIRRHGLAILLSVAAWGLAIAVFGMTRNLWLGLFFLALAGCADTISMVFRSTMMQTATPDGMRGRLQGVYIVVVAGGPRLGDFLAGTVADLTSPAVAITGGGLACVVVLALLAARWRSFARYDSRSPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXQ1</accession>
    <name>A0A0F4JXQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_02040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000028">
        <property type="protein sequence ID" value="KJY39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945593.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39157">
        <property type="protein sequence ID" value="KJY39157"/>
        <property type="gene ID" value="VR44_02040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5816"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="33"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="459" mass="50985" checksum="EC87210E95A02FAE" modified="2015-06-24" version="1">MNDSQLVRPLPVSGFPEWLPEIRMVEQRWLDVIRSGFERYGFCSVETPSVEPLSVLTAKGETSNEVYALRRLQEDADDTSDSRIGLHFDLTVPFARYTAQHFNELVFPFKRYQMQRVWRGERAQDGRFREFTQCDIDVINVDRLPLHFDAELPRMIHEVMTALDLPEWTLGINNRKVLQGFYEGLGIADPLAVIRAVDKLDKVGPEGVARLLSGELGLPARTVDSCLALARLRGEGPAVVDAVRDLGVTSDLLAEGLDELGYVLDSLGDLPAGAVVADLSIARGLDYYTGTVYEGKFTDWPDYGSICSGGRYENLTGSFIRRGLPGVGMSIGLTRIFAKLLAEGLLETGPKCPSQVLVVIPADERRRAAETTAAGLRRRGMNVELYHQADKVAKQLRYASRKGIPFVWFPPFEEGGNHEVKNLTTGEQTPADPAVWVPSPRWTSSEEVGQMVAVSMTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY92</accession>
    <name>A0A0F4JY92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_02210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945626.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39100">
        <property type="protein sequence ID" value="KJY39100"/>
        <property type="gene ID" value="VR44_02210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5707"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="31754" checksum="86526287137C3EE8" modified="2015-06-24" version="1">MDEKDELARRFDAHRAHLRAVAYRMLGSLGDADDAVQEAWFKLNRTDVGAVENLGGWLTTVVGRVCLDMLRSRSARREESLDAADLPFRMPDPVVGLPGRVDPEQEALLADSVGIALMVVLESLAPAERLAFVLHDMFAVPFEEIAPLVEKSSAATRQLASRARRRVRGAAPAPDTDPVRVRRAVDAFLSAARDGDLEALVAVLDPEITARSDGGTRRPGALLRGARRVASQAIAFARFAQDGRAVLVNGGPGVLALDADGHPVSLMAFTVRGGLITALDILTDPDRLACIRLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ88</accession>
    <name>A0A0F4JZ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein hspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945527.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39420">
        <property type="protein sequence ID" value="KJY39420"/>
        <property type="gene ID" value="VR44_01695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5741"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="17110" checksum="71D0836EF6B045B4" modified="2015-06-24" version="1">MEGRRRQPRFGDGAYQLTDETPVYVISVAAQLSGLHPQTLRQYDRLGLVSPDRTAGRGRRYSARDIELLRTVQQLSQDEGINLAGIKRIIELENQVAALQQRVAELSAAVDGAAAALQAREAAVHASYRRDLVPYQPPQPGNALVVWRPKRPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZH9</accession>
    <name>A0A0F4JZH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945505.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39515">
        <property type="protein sequence ID" value="KJY39515"/>
        <property type="gene ID" value="VR44_01540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4741"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="31089" checksum="DE7120485B6137CD" modified="2015-06-24" version="1">MDAARTAGLLTTAQAADALAGALRAGLDPEACPRRSSVSAPGGELLLMPAASGAYAGVKIAGVAPGNPARGLPRITGSFLLLDGPTLRPLALLDGAALTALRTPAVSALALRYLTGPGRPLRLVLFGAGPQAYGHLEAVLELRELAEAVVVARDPGRAGELAAHARTLGVPARTGTPEDVAGADLVLCCTSAREPLFDGRLVAPGAVVVAVGSHEPDARETDTALVRRAAVYVESRAAALREAGDLLIPEAEGAIGPGHISGTLAELVAGGNSPGGRPGCPQLFKSVGMAWEDLAVAVAIYHAAGANGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Y4</accession>
    <name>A0A0F4K0Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_01190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945437.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4706"/>
    <dbReference type="EnsemblBacteria" id="KJY39588">
        <property type="protein sequence ID" value="KJY39588"/>
        <property type="gene ID" value="VR44_01190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2953"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="24905" checksum="394D369B99E79CD7" modified="2015-06-24" version="1">MYNPTVARLTYRALLGRRRAAILFALPALLLVISLTVRFFTGVDDKVAAELLGGFALATMVPLIGVIAGTGAIGPEIDDGSIVYLLSKPVKRPTIIMTKLTVAIAVTMAFSAIPTLIAGFILNGNGQQIAVAYTVAALVASIAYSALFLLLGTVSRHAVVFGLVYALIWESLFGSLVSGAKTLSVQQWALALAEKVAGQGYVDSSVGLPTAVILLLAVTVGATAYAGQKLRRLTLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K189</accession>
    <name>A0A0F4K189_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein VR44_00120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945264.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene990"/>
    <dbReference type="EnsemblBacteria" id="KJY39904">
        <property type="protein sequence ID" value="KJY39904"/>
        <property type="gene ID" value="VR44_00120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.22"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16369" checksum="D8FBACF5A5C54E0A" modified="2015-06-24" version="1">MALDQTFVGRTYPPTEPYEVGREKIREFAVAVGDENPVYTDPEAAKAFGHQDVIAPPTFVFAITFAAAGQVVQDPQLGLDYSRVVHGDQKFAYVRPVRAGDRLTVTSTIEAVKSLAGNDIIDIRGEVHDESGEHVVTAWTKLVSRAPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1A9</accession>
    <name>A0A0F4K1A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945679.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39001">
        <property type="protein sequence ID" value="KJY39001"/>
        <property type="gene ID" value="VR44_02495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6803"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="10631" checksum="80CE8FD4F43BA0B8" modified="2015-06-24" version="1">MADTTWTTTGVYTGSGGVLTDEAGILTGELTVRTTWEPERAHVCVQYVGATEWYALAGSPLPCASAEAGRSLHQSAVDAVRAGGATPFAPIVSVGSASAWGAFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAU7</accession>
    <name>A0A0F4IAU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">VR44_39205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001564">
        <property type="protein sequence ID" value="KJY19150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952465.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001564.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19150">
        <property type="protein sequence ID" value="KJY19150"/>
        <property type="gene ID" value="VR44_39205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5643"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY19150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="444" mass="47449" checksum="6871E5E82690E0C2" modified="2015-06-24" version="1">MRDQFPLHDPLDPASETAGLLALDRQHVWHPYGPMPGRQETLVVSSASGVRLRLASPAQGREELVDGMSSWWSAIHGYNHPVLNEAATSQLGRMSHVMFGGLTHEPAVRLAARLVEITPPGLEHVFLSDSGSVAVEVAVKMCLQYWRSLGRTGKTRLLTWRGGYHGDTWQPMAVCDPEGGMHELWQGHLPRQVFAGAPPGDFDTPVDPAYADHLRSLVAAHADELAAVIVEPVVQGAGGMRFHHPGYLRVLRELCDEYGVLLILDEIATGFGRTGALFAADHAGITPDVMCLGKSLTGGYLTLAATLCTERVADGISQGEVPVLAHGPTFMGNPLAAAVALASVDLLLGQDWAGEVARIEAGLRSGLAEASGQPGVKDVRVLGAIGVIQLDHPVDVWAATRAAVREGVWLRPFRDLIYTMPPFVTGDADVARICRAAVAAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IF50</accession>
    <name>A0A0F4IF50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001494">
        <property type="protein sequence ID" value="KJY20655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20655">
        <property type="protein sequence ID" value="KJY20655"/>
        <property type="gene ID" value="VR44_38620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17682" checksum="DC69495C7964278C" modified="2015-06-24" version="1" fragment="single">PPPVPPQRRPRPRNAWIDSGSGLSHLMRQWRDTPQSGVWREAKQRFQAALAEAERLRDERAAAADAYAGQAAAYEALHAARLAAERDAAALARVREDLPGAEAALARAQQQLADAEQAHQAHLARRPGFSVSLFTMGRAARAWHADEAGAAGLAADARKAREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILT7</accession>
    <name>A0A0F4ILT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_37735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001405">
        <property type="protein sequence ID" value="KJY23000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23000">
        <property type="protein sequence ID" value="KJY23000"/>
        <property type="gene ID" value="VR44_37735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="364"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY23000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="508" mass="53544" checksum="1A6BACDB92061A52" modified="2015-06-24" version="1" fragment="single">MSGRAPVLDDPEQLKELLGIPFTPEQLACVTAPPAPQVIVAGAGSGKTTVMAARVVWLVGTGAVAPEQVLGLTFTNKAAGELAERVRKALARAGITDPDPSPAPGAGPDAAAGGEPRISTYHAFAGQLLKDHGLRIGLEPSARLLADATRFQLAAKVLREAPGPYPALTKSVPDLVSDLLALDGELSEHLVEPAELRAYDTELLGVLADTRLTNEDLRKVPEAVRGRLELLELVVRYREAKRSRDLFDFGDQIALSARLATTRPEVGALLREEFRVVLLDEYQDTSVAQRLLLSGLFGSGSSQDGVRGGGTGHAVTAVGDPCQAIYGWRGASVANLDDFPEHFPHADGTPATRLSLSENRRSGGRLLDLANGLAAPLRAMHEGVEALRPAPGAERDGLVRCALLPTHAEELEWLGDSVAHLVRTGTAPGEIAVLCRSAADFASIQAVLVARDVPVEVVGLSGLLHLPEVADLVSVCEVLQDPGANAALVRLLIGPRWRIGARDLALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQH4</accession>
    <name>A0A0F4IQH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001377">
        <property type="protein sequence ID" value="KJY23733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23733">
        <property type="protein sequence ID" value="KJY23733"/>
        <property type="gene ID" value="VR44_37440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7151" checksum="11EEDD8E07770DAB" modified="2015-06-24" version="1" fragment="single">SGKPGKSAPAGKPAKKKGRSKLVLLGGGVLGLAAVAYGAGLLMNHSDIPKGTKVLGVDISGSRDDAVAKLQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQW6</accession>
    <name>A0A0F4IQW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001338">
        <property type="protein sequence ID" value="KJY23888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001338.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23888">
        <property type="protein sequence ID" value="KJY23888"/>
        <property type="gene ID" value="VR44_36950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4773"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="11135" checksum="8A58989FAF132CBB" modified="2015-06-24" version="1">MTGRGEAVENEQGWAWECDPSRIWVLGEMADEHQALVSGVMDGLVDLASMGIDPKTGSLYEDPAPMRLRTYEDERLMVWYQTIRHRHRVYLKRVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR23</accession>
    <name>A0A0F4IR23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_36855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001330">
        <property type="protein sequence ID" value="KJY23923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23923">
        <property type="protein sequence ID" value="KJY23923"/>
        <property type="gene ID" value="VR44_36855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY23923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="32484" checksum="6E0B25A4D9E80AF6" modified="2015-06-24" version="1" fragment="single">MSNGWAVPGYTEVRELGSGGSGRVVLAVHEATGTAVAVKYLSDRMREDPAFVREFRAEARLLGGLVSPYVTGFYEYVEAPDGAAIVMELVDGVSLRTVLRESGRTEPEAALVVLKGSLLGLAAAHRAGVVHRDYKPENVLVAADGSSKLVDFGIAAGRGSTPGVAGTPAYMAPEQWQGQPASPTADVYAATATFFECLTGRKPYDGGNFAELAVQHIEAPVPETEAPEAVRPLIRRGLAKRPEQRPENAEAFVAELEALAVAAYGPRWEERGQRKLAALAALLPLLFPSAGGAAAGTTAVATTSIGSGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK4</accession>
    <name>A0A0F4IRK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001252">
        <property type="protein sequence ID" value="KJY24299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951821.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001252.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24299">
        <property type="protein sequence ID" value="KJY24299"/>
        <property type="gene ID" value="VR44_35770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4308"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="16170" checksum="E66AB76CA8CF8C47" modified="2015-06-24" version="1">MDLPQLLLVGLVLLLGVVGVLVPGVPGTWLVWAGVLSWALHEQTAPGWALLAGSTVLLLVVQVVKGRLPPRRLRGVGVTRRMGAGALVGFVVVPLVGAVPGFVGGIYLCERRRLGTHGEAVASVRAVMRAVGTSVLVELMACLTVVAAWGVTVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRM9</accession>
    <name>A0A0F4IRM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001189">
        <property type="protein sequence ID" value="KJY24647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24647">
        <property type="protein sequence ID" value="KJY24647"/>
        <property type="gene ID" value="VR44_34685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4002"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11141" checksum="BD78ABE282B6AF07" modified="2015-06-24" version="1" fragment="single">MTALLRYQGALLLRSQRWLAPFAVYAVFVGIGIQPGDRTLDSLGYAAAGLVPLTAWLVRVCVTAEPPAARACTAAAAGPARVHAAALLTGLAGALLTGVLAAAYPLLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRP7</accession>
    <name>A0A0F4IRP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001282">
        <property type="protein sequence ID" value="KJY24148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951905.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24148">
        <property type="protein sequence ID" value="KJY24148"/>
        <property type="gene ID" value="VR44_36205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4485"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="30713" checksum="6002E3305520F4B0" modified="2015-06-24" version="1">MSSPAVPLPSAPSPAGSPVARAYGRLTAAYPGLRIREHGASEPLPRGAGWVGAHELAAGGEALDAHLAWDAAQVVRDYGRPARPDVVAGFGLHRYAWPFCLLITVPWFLERRVPRLPVDRVAFHRTEGLMAVRVEEFACLPGDPAAALPGARTVAGEAELREEVRQAVAGHLGPLLEGFGPRMRRGSRALWATATDEVVEGLWYLGGLLGEERRAVRELQLLLPGALAPYPGGARFRTLAGPGGTELTTRDRAGCCFFYTVRPDDTCTTCPRTRDAERVARLAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISB8</accession>
    <name>A0A0F4ISB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001209">
        <property type="protein sequence ID" value="KJY24539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24539">
        <property type="protein sequence ID" value="KJY24539"/>
        <property type="gene ID" value="VR44_35075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="196"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="420" mass="43190" checksum="815C5CF3BA89C2F8" modified="2015-06-24" version="1" fragment="single">GIAGVLKSVLALQHGVLPRTLHAETPSPHVDWTAGRVRLLTDAVDWPATGRPRRYGVSSFGISGTNVSGTNAHAILEEPPADPEAAATPAQAEPAGAEAAGAEAPAVPWVLSARSPEALAARAEALLAHTAAHPGLRPADIGHALATTRTAFEHRALVTGATGAELTEGLRALAAGGSTPRTARGTAAHGRRVAFVFPGQGSQWAGMAVGLLDTSEFFRERIAACGRALAPYVDWDLEGVLRGAPGAPALDSADDVVQPALWAVMVSLAELWRSFGVEPSAVIGHSQGEIAAAAVSGALGLDDAARVVALRSRLLARLAGLGGMVSVPEPLADVTRRLEQWGERLGVAAVNGPRSTVVSGDADALEEFLAACTADGVRAKRVPVDYASHSAHVELIEAELAEALAGITPRTPRVPFYSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISD6</accession>
    <name>A0A0F4ISD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001149">
        <property type="protein sequence ID" value="KJY24912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951493.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24912">
        <property type="protein sequence ID" value="KJY24912"/>
        <property type="gene ID" value="VR44_33980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3721"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23914" checksum="C5178F699B7D6A11" modified="2015-06-24" version="1">MIRVLLADDQLLVRAGFRALLDAQADIEVTGEAADGRQAVRLARELRPDVVLMDIRMPDLDGLAATRAITADGALGEVRVVMLTTFELDEYVFEAIRAGASGFLVKDTEPEELLRAVRAVVAGDALLSPGVTRRLIAEFAARSREPASAGGLERLTDREREVMALVGMGLSNEEIARRLVVSPLTAKTHVSRTMVKLGARDRAQLVVLAYESGLVRPGWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISF2</accession>
    <name>A0A0F4ISF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001146">
        <property type="protein sequence ID" value="KJY24930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951483.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001146.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24930">
        <property type="protein sequence ID" value="KJY24930"/>
        <property type="gene ID" value="VR44_33920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3710"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24506" checksum="134847DCD0330E67" modified="2015-06-24" version="1">MGAEVPVSDGTAHIVWDWNGTLLHDIDAVMTATNASFAELGFPPITLERYRELYVVPVPKFYERLMGRLPTEAEWVVMDEAFHRHYWAAAADSGLAEGARELLRGWQADGFTQSLLSLAPHDKLVPLVREHRIDVHFLRVDGRTGPSHTSKAGHLVRHMAAMEAAGVTASRTVLVGDAVDDALAAAHVGARAVLYTGGSHSRASLETAGVPVVDSLAEAVATARELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISL5</accession>
    <name>A0A0F4ISL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001385">
        <property type="protein sequence ID" value="KJY23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952151.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001385.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23701">
        <property type="protein sequence ID" value="KJY23701"/>
        <property type="gene ID" value="VR44_37540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23612" checksum="633ADCB9F7416D29" modified="2015-06-24" version="1">MSKVVNYSMANRGQVLRFVPAEDLSADGSRRLDSMRRTARARQDSLDHQGVDWGLSVPDALEELTAGRAGSSAAYAGSAYYAALQIIIDHNASDPDTLGSYRSPLTLFSALDDALGAQGVPAELLPRQYVFSGPPSEIGFHIPHPMDGSPEIGCWPLAKAVPAVEAYRAVLDRIDPDLRYDLEELVKALDGWASEWKEGQGAWWWAEDGSVFFSITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITQ8</accession>
    <name>A0A0F4ITQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_34130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001156">
        <property type="protein sequence ID" value="KJY24868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001156.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24868">
        <property type="protein sequence ID" value="KJY24868"/>
        <property type="gene ID" value="VR44_34130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3752"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20586" checksum="1B469D88847FFB45" modified="2015-06-24" version="1">MGRIGLTTDRLVRAGAELADEVGFEQVTASALARRFGVKVASLYSHVRNSRDLKARIALLALEELADRAASALAGRAGKDALTALADVYRDYAREHPGRYDASRFRLTPEEAVAGAGRRHSEMMRAVLRGYDLTGPEQTHAVRLLGSVIHGYVSLELAGGFSHSAPDPQESWSWTLDSLDTLLRTRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVD5</accession>
    <name>A0A0F4IVD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001050">
        <property type="protein sequence ID" value="KJY25604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25604">
        <property type="protein sequence ID" value="KJY25604"/>
        <property type="gene ID" value="VR44_32080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3134"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17577" checksum="0D95938D1C9682FF" modified="2015-06-24" version="1">MRSVFLAGPFIQLLDPETGEMPAGARAPFDVLIKHFEAQGLSVHNAHRREAWGAELMRPEQCTKLDQDEIRKADVFVALPGHPASPGTHIEIGWASAFDKPIVLLLERDREYTFLVQGLHTVASVEYVVHTDIAACLPAVDRAVDLAVMRQREGSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVI9</accession>
    <name>A0A0F4IVI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001179">
        <property type="protein sequence ID" value="KJY24706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24706">
        <property type="protein sequence ID" value="KJY24706"/>
        <property type="gene ID" value="VR44_34535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="14662" checksum="2205BFB1858BCB2C" modified="2015-06-24" version="1" fragment="single">MSYAREVNFPEGTRIFEEGGRAESFWIVRSGTVTLEVPLPSGGHRGAAPVESLGPGELVGWSWLFPPYTWQLSAEAMTPVRAYEFDGAAVRMLMDADPAFGSAIGHWVGRILAVRLQQTRNRLLDLYAPRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW07</accession>
    <name>A0A0F4IW07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25819">
        <property type="protein sequence ID" value="KJY25819"/>
        <property type="gene ID" value="VR44_31525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2800"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="25656" checksum="D6BE422C3B33EC48" modified="2015-06-24" version="1">MDMDQNDTGRRVVLVTGAGTGIGRATARAFAAAGDRVVVVGRRKAPLEETAEGHPGIRVLAGDVGGSGEPERIVGEVLGAHGRLDVLVNNAGIVRGAALGRVVAGDVAEQLAVNLVAPVLLTQAALPALEASGSGVVVNVSTAVGQRAWPGASVYAATKAALDTLTRSWAVELAPRGVRVVAVAPGAVDTPIGEHQGLSPEQAARVRAWQLAHTPLGRIARPEEIAWAVCRLADPGASFVTGVVLPVDGGASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW23</accession>
    <name>A0A0F4IW23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000967">
        <property type="protein sequence ID" value="KJY26235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26235">
        <property type="protein sequence ID" value="KJY26235"/>
        <property type="gene ID" value="VR44_30575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2533"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469882" evidence="3">
        <location>
            <begin position="34"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="22805" checksum="37F7D5CD578B38E3" modified="2015-06-24" version="1">MGAIRSSATALLSAGATGLALALGAFGAPAALAAEAAPATSFAFAVTPSRIAPGGTVTLSVSNCGAAYATASSGVFDTVTIERGKTVKVTIDRDARPGALYSVTFTCGSENGSADLTILGGTTQPTTSSTTGTRRTPSPAATSGSGLRPPPSTTSPPRTTPPARTTTPARTTPPARTAPVPRATTATLGVRGGLGGSIAGADPAELGAGAALFIAAAGGTAYALRRRRRAARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWK1</accession>
    <name>A0A0F4IWK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001018">
        <property type="protein sequence ID" value="KJY25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951020.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25848">
        <property type="protein sequence ID" value="KJY25848"/>
        <property type="gene ID" value="VR44_31430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2777"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="33393" checksum="EAADD7CBDD5DD007" modified="2015-06-24" version="1">MSELEVRELRYFIAVAEELNFSRAAQRLGMAQPPLSKAIAQMESRLGVRLLERTTRQVRLTDAGQVLLGQARIAVDAVHAAARRTRRAGQPAPQLVVAVKPGGDAGLLREILAAYRESGTRLPPPEVLVGGSGEPIAMLRDGRADVALLRSPFDGQGLDSQTLVIEPRLAVLPAGHPLAGRRRLRLADLQGEPIPRWKGAAPSHTAYYTGCDGAEAGGGPTGPAPAADAPEGPLVAGVEQLLEVVALGQAVAFLALSTTERHQRPDIAYRPVTGLSPSEVVVAWPETSRSPAVAAFVRAAHEVAAHHPDHLASLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXH9</accession>
    <name>A0A0F4IXH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26712">
        <property type="protein sequence ID" value="KJY26712"/>
        <property type="gene ID" value="VR44_29390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2242"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470520" evidence="2">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="20596" checksum="DA1208A202411C6F" modified="2015-06-24" version="1">MFQHGSSRSAAARRAGLVAALGLGLALTAACGGKDTGSGSSSSSKGGSGSWQAGDCGGPDPKQAPDGYRAMGCDESGATFKALEVTSAGILPGSVQCPAGTDLMIRVSVSYGSSKDKSKGGGIPTHTVCGRNLSGDHPGDAGAGGGQLVKGDCVSSSAQEVACASAGRDAFKVLDLVKEKEQCPAGTSEPMELTLSIGRPYDVICAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXP2</accession>
    <name>A0A0F4IXP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950616.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000904.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26782">
        <property type="protein sequence ID" value="KJY26782"/>
        <property type="gene ID" value="VR44_29205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2186"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="25432" checksum="3D186FDD18BC15C2" modified="2015-06-24" version="1">MKHHAADAHTLAAAYALGALEEDERRAFDAHLQSCEACRQEAAEFQTTAARLAAAVSQPPPPSAKAQVMAAIDGVRQLPPRVPAPASTAPASGGLLTRRAVPLALAASVAAAALGGIAVWQTQNGQDLEARARQAQQQLDTISTVLAAPDARTVHGRAANGALTTVVASARQNKAVFTAANLPAPGAGKTYQLWLDHNGTMRPAGLIDHDGTVILAGDPTGAGAVGLTLEPAGGSPQPTTDPLLLMILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXR4</accession>
    <name>A0A0F4IXR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Cse3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000962">
        <property type="protein sequence ID" value="KJY26258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950858.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000962.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26258">
        <property type="protein sequence ID" value="KJY26258"/>
        <property type="gene ID" value="VR44_30535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2522"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01907">
        <property type="entry name" value="casE_Cse3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="26604" checksum="4F41679BF05DF147" modified="2015-06-24" version="1">MFLTRFRINTARRESRNLLSSPQHMHAAVMSSFAGALPSAENSSRVLWRLDRNAKAEVLLFIVSEERPDLTHLVEQAGWPTTAAWQTYDYKAFLDGLSLGTTWAFRLTANPVHHVRRTPDEPRKRTAHRTPRHQMGWLLKQQENAGFKILETPAERRRLLQGDEHQLTVRDERRHRFSKTELITGKVNEVPLVTVTFDGRLEVTDPVALRRTLTSGLGKAKAYGCGLMTLAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXT4</accession>
    <name>A0A0F4IXT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951204.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25471">
        <property type="protein sequence ID" value="KJY25471"/>
        <property type="gene ID" value="VR44_32410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3285"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14971" checksum="D024F1208940E9D7" modified="2015-06-24" version="1">MDISIHTTSLPHEDPDASLAFYRDVLGFEVRSDVGQGRMRWITVGPAGQPGTSILLAPPAADPGITEDERRMITEMMAKGTYGWILLATPDLDATFEKVQAGDTEVVQEPTEQPYGVRDCAFRDPAGNLIRIQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY79</accession>
    <name>A0A0F4IY79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000882">
        <property type="protein sequence ID" value="KJY26952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950532.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000882.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26952">
        <property type="protein sequence ID" value="KJY26952"/>
        <property type="gene ID" value="VR44_28745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2081"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26900" checksum="87AD5A92B7B00874" modified="2015-06-24" version="1">MSTILVTGGTGNLGALVVGMLREQGHEVRALSRSSAEFPVDLRDGSGLDAALAGAQVVVHCASSPRGGDDVAARHLIDAARRAGTVTNLVYISIVGVDVVPLGYYRTKLRVERMLEDSGLGVTILRTTQFHDLVARVTGVAARLPLPVVPLPKGVRVQPVAVEEVADRLAELAVPEAAGRVPDVGGPEARPLEEWAGVWLAATGSRRRVLGVPLAGRAYAACRRGGILAAPGRAVGRITFDDYVERRGRVRGTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYL7</accession>
    <name>A0A0F4IYL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_28420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000868">
        <property type="protein sequence ID" value="KJY27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950472.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000868.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1150"/>
    <dbReference type="EnsemblBacteria" id="KJY27120">
        <property type="protein sequence ID" value="KJY27120"/>
        <property type="gene ID" value="VR44_28420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2009"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="32463" checksum="534BB8A7E9E75080" modified="2015-06-24" version="1">MAEVLVYVDHVDGAVRKPTLELLTLARRVGEPVAVALGAGAEATAAVLAEHGAVKVLTADAPEFAEYLVVPKVDALEAAYKAVSPAAVLVPSSAEGKEIAARLAVRIGSGIITDAIDLEAGDEGPVATQSAFAASFTTKSRVSKGTPVITVKPNSAAVEAAPAAGAVEALAVTFGALATGTKVISRTPRESTGRPELTEAAIVVSGGRGVNGAENFHLIEELADSLGAAVGASRAAVDAGWYPHTNQVGQTGKSVSPQLYIAAGISGAIQHRAGMQTSKTIVAVNKDAEAPIFDLVDYGVVGDLFEVVPQLTGEIKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZU3</accession>
    <name>A0A0F4IZU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950521.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26988">
        <property type="protein sequence ID" value="KJY26988"/>
        <property type="gene ID" value="VR44_28685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2068"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13716" checksum="51CC2EF39785E91E" modified="2015-06-24" version="1">MSRTTACTAQEGVGREVCTVLDVLGRVSGKWSLGVLSETLHGPVRFSALERSLAGISRRILTLTLRELEEDGLLVRTVHPTVPPRVEYAATDAARELYERLTGLADWARRHPEAAAAGRRPGGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J026</accession>
    <name>A0A0F4J026_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000813">
        <property type="protein sequence ID" value="KJY27620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950254.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000813.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27620">
        <property type="protein sequence ID" value="KJY27620"/>
        <property type="gene ID" value="VR44_27200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1629"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="229"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1416" mass="151184" checksum="BD29A02372627970" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0F6</accession>
    <name>A0A0F4J0F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000843">
        <property type="protein sequence ID" value="KJY27374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950355.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000843.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27374">
        <property type="protein sequence ID" value="KJY27374"/>
        <property type="gene ID" value="VR44_27770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1792"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12966" checksum="E0B67E05206ECF63" modified="2015-06-24" version="1">MEARAPRPGVPVRGSGSGRPVMAALDLLGRRWTMRILWELSQAPAGFRELQRRCERMSSSVLSTRIEELTDARLLALDGDGYHLTPLGQGLVEALKPLGAWSRRWAEEMGPATEGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1D7</accession>
    <name>A0A0F4J1D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28100">
        <property type="protein sequence ID" value="KJY28100"/>
        <property type="gene ID" value="VR44_26070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1369"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470040" evidence="1">
        <location>
            <begin position="30"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="40877" checksum="3CDA9B317E8ADFF8" modified="2015-06-24" version="1">MGRGPLRRIGVLAAVLGLLAAPSAGAAWADTGADGVRGAALPAGAPTRTAAGELAAVIDAAAPAGYADTYAGVSVDAGAGRVTVFATDTGRGRALAAAAERSAHSGGRVRVEVKAAKYSRRQLEAARTELEAAADGWRASGPQVSMVSFGAEGDGLRVAADDPARAAALNRARPVRQGAGAGVDPADVRFLAATPVPVVERDNDGAPHWGGATITSSSAQCTTAFAMDVPGWDRYMVTAAHCGGAGTHFTSGSSDYGTVFNTLPSIDAGIIKTAGGSNSGVYIGTEGRAYANWVWSLMGEEVCQSGSVTRYRCGIFVTGDAQHWDNGIWVQGGIEACTRDGSAAVRPGDSGGPVFNWRADGKITSRGVISYGYASGSTGGGLNCIGWSQTGHVLASWQASLVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1L2</accession>
    <name>A0A0F4J1L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000799">
        <property type="protein sequence ID" value="KJY27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950182.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000799.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27759">
        <property type="protein sequence ID" value="KJY27759"/>
        <property type="gene ID" value="VR44_26800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1518"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13502" checksum="5497D737ECA23258" modified="2015-06-24" version="1">MRIGELAARTGVGERSLRYYEQQGLLASDRTPGGHRDFPERAVDRVIRIQELYAAGLNSSKIGQILPCMRDEDGGPSVRATPALVAELAAERDRIDRMIGDLVRSREVLDEAIVAASGRIAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1X3</accession>
    <name>A0A0F4J1X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000746">
        <property type="protein sequence ID" value="KJY28275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28275">
        <property type="protein sequence ID" value="KJY28275"/>
        <property type="gene ID" value="VR44_25755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1256"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7019" checksum="C0E4227B738D311D" modified="2015-06-24" version="1">MVLVEPYLAGTSAAAAGQALIDVPHRVLPLGVGRAELRRFGTIEEHTAAHGLDAGSLRQRITAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1Z8</accession>
    <name>A0A0F4J1Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_28920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000887">
        <property type="protein sequence ID" value="KJY26916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26916">
        <property type="protein sequence ID" value="KJY26916"/>
        <property type="gene ID" value="VR44_28920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2124"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="542"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1115" mass="116018" checksum="BAF25EAA6BE8E427" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2I9</accession>
    <name>A0A0F4J2I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000723">
        <property type="protein sequence ID" value="KJY28517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28517">
        <property type="protein sequence ID" value="KJY28517"/>
        <property type="gene ID" value="VR44_25155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1123"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17791" checksum="5355001F9628C198" modified="2015-06-24" version="1" fragment="single">RPARHYGARVIATASPEKHDTVKALLGADEVLDSRRPDLAEEITRLTGGVDLVLESVGQATFEASLSVTKPFTGRIVVFGAASGDATVTTRELVFTHQVQIKGLHIGALAAAAPSLYQSLLVEIEALIAHGVYPPGIPHVHPLAEGPAVLQQLEAGQTRGKLALDPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J487</accession>
    <name>A0A0F4J487_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000800">
        <property type="protein sequence ID" value="KJY27751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950186.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000800.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27751">
        <property type="protein sequence ID" value="KJY27751"/>
        <property type="gene ID" value="VR44_26830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1524"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="416" mass="44232" checksum="88D3838F530E3D72" modified="2015-06-24" version="1">MTLSRRGLLGLAGTAGAAGAVGAGRRPAGSPPPGRVRTGFERLAADGYAELAGRRVGVVTNPTGITADARHVVDVMHADERVDLVAVFGPEHGFRGTAQAGGSEGAGRDPATGLPVYDTYDRSGQRLADLFTAAGIDTLVFDVQDVGARFYTYVWTLYDCMRAASLADKAVVVLDRPNPVGGLRAAGPVLQRPYASFVGREPIALAHGMTVAELALLFHGEFLGSAGPRLRTVPMEGWRRGSFFGETGLPWVPPSPNVPTPDTALAYAGTCLFEGTTLSEGRGTTTPFELVGAEGVDRRWAEAANGLGLAGVWFREAWFTPSFSKHAGKVCGGVRLIVHDREAFDPVRAGIGLLVTARRVWSGFGWRRDRWIDRLTGSDRVRTLVDAGAGVDEVAGDWAAGLARFAAVRERYLLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4L4</accession>
    <name>A0A0F4J4L4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">VR44_24605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000703">
        <property type="protein sequence ID" value="KJY28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949769.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000703.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2998"/>
    <dbReference type="EnsemblBacteria" id="KJY28769">
        <property type="protein sequence ID" value="KJY28769"/>
        <property type="gene ID" value="VR44_24605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.916"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="379" mass="40403" checksum="08A0FAD06DC2996B" modified="2015-06-24" version="1">MTENLPRTARPLRVLAAMSGGVDSAVAAARAVEAGHDVTGVHLALSANPQSFRTGARGCCTIEDSRDARRAADVIGIPFYCWDLAERFREDVVEDFVAEYEAGRTPNPCLRCNEKIKFAALLDKALALGFDAVCTGHYATIVEKEDGTREMHRASDMAKDQSYVLGVLDEKQLAHALFPLGDTVTTKDEIRAEAERRGLAVAKKPDSHDICFIADGDTQGFLAKRLGKAEGDIVDGATGEKVGTHDGAYGFTIGQRKGLRIGHPAPDGKPRYVLDISPVNNTVTVGPVEALDVTALTAIRPRWCGSTPAPAGTYTYTAQLRAHGGETEVFAEVVDGELHVRFTEPVRGVAPGQAIVLYDGTRVVGSATIATTTRATAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5D9</accession>
    <name>A0A0F4J5D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000687">
        <property type="protein sequence ID" value="KJY28973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949660.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000687.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28973">
        <property type="protein sequence ID" value="KJY28973"/>
        <property type="gene ID" value="VR44_24030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.798"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23210" checksum="EBB9840B3F2EB252" modified="2015-06-24" version="1">MRWTGPSRRSVATSRPSTRVLGYLESKKNLVGSACGLAGLALTVAGAAGAYWPVVIAGLYGAGALIAPPERASVPVFPGTAEQLGVVREDLARLREYAAEVELPPAAEGKLGGLLDLYGALLEPGWGTEALATEPDAVHALSRAIRLDVPECVDTYNRTRWWTRLTPGGESPERHLERQLSVLSEEAERLTAGLQDREARRQQTHTAYLEERGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J682</accession>
    <name>A0A0F4J682_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000609">
        <property type="protein sequence ID" value="KJY29872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29872">
        <property type="protein sequence ID" value="KJY29872"/>
        <property type="gene ID" value="VR44_21780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.236"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="20046" checksum="A5DE17E4A1DA0C74" modified="2015-06-24" version="1">MAVVNIVNAVPPPRAPSRADTRTWYERVLGWAVAAGPPVRLVTGVRFDVLEVPADAGAGLLRRPGLATGPVALEGRTMRFLVAPGAAEELDGLLDWLEWGGVELELTALGAGGGITAPVPPGRGPGGDPRRAAVWLRPPETGCEASLPALPGPGRGAGAGPGGSGGPDLVRLVAAAATECHRARLWRRTGQPLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L5</accession>
    <name>A0A0F4J6L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29855">
        <property type="protein sequence ID" value="KJY29855"/>
        <property type="gene ID" value="VR44_21830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="17816" checksum="EF98C7B0F87C4D4A" modified="2015-06-24" version="1">MKNHEAETAVEAAVAEELLNAVGPAFGKLRRSSLLEVENPISQKDLGRTLVLNVVLEIARDDTEVTVGAVASHLGVDPSVASRMVSDCISAGYLVRAASQRDGRRTVLHLSPEGEELMARFRRHQRSAYEHITADWSERDRLELARLMVKYVAAQEALRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Q6</accession>
    <name>A0A0F4J6Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000595">
        <property type="protein sequence ID" value="KJY30042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30042">
        <property type="protein sequence ID" value="KJY30042"/>
        <property type="gene ID" value="VR44_21370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="25564" checksum="02B5E433F598B531" modified="2015-06-24" version="1" fragment="single">HVPFPPDAAPDVPEFAGPLAEELERVAGARRDDHALPWEVWRPGLLRAARRVVAGGAAADDTLLSEVLLRTAAAAGTRAHDGRAAALTRRIAPYLADPEPGTVAAGLARGTAAGPAGVPAARTEGATPADGGGREKALAHALAVVSEAAVTTALQALALTAAGVPEAAGGPAGAVALALRRFPPVEAAVHPVRARFVWEGLAVDPGTEILAAPGWLREDPDADTPVDGGGALRPGPPSPLCGAATGCAATAFAARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W0</accession>
    <name>A0A0F4J6W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949401.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29569">
        <property type="protein sequence ID" value="KJY29569"/>
        <property type="gene ID" value="VR44_22605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.413"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="43515" checksum="5353B53D6D1832C0" modified="2015-06-24" version="1">MTESPRPGRLRAALPPVVAWLVSNLVTWAVAHASVAGDGYPVAYWSTAARRRWDSEHYLSIARGGYEMFRCRERYANFPDVMCGNVAWFPGYPMAVRAVSGTGLSYELSALVVTEAALLGMFAVLWWLLGAVLTRATGLTLAIGTVFPGGVYFHALFPVALATLALLVCVAGLGRGSWWTATAGGFVAVACHPVGAVAAVLLMSSALFAWRGETWPRRCAKAAASAVVAGCGVLWAKWLMWQATGHWDAYETIQRSSYGQGDLRQPFAEMARAYAVPFRDWYTPEGHLPWLVGHALAAHRPQLWLNTAFVVLVVATAVVLLVRERRLSVVEWAALVLTVAVFLVPFVAGAQMSWYRNHAQMFAGLVLVRRMSPWVQVPLLAACAAQYALLGAMFFAGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7A4</accession>
    <name>A0A0F4J7A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-myo-inositol dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000700">
        <property type="protein sequence ID" value="KJY28821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949745.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000700.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene799"/>
    <dbReference type="EnsemblBacteria" id="KJY28821">
        <property type="protein sequence ID" value="KJY28821"/>
        <property type="gene ID" value="VR44_24480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.891"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="33548" checksum="AF2AFE393CA528D9" modified="2015-06-24" version="1">MTSSPPALTRIRVGSAPDSWGVWFPEDPLQVPWDRFLDEVVGAGYEWIELGPYGYLPTDPARLADETAKRGLRVSAGTVFTGLHHGPAVWEETWAHVSRIAALTRDMGAEHLVVIPSFWRDDKTGGMLEDPVLTPAQWRELTTQTERLGREVRERYGLRIVVHPHADTHVDTPENVARFLDATDPELVSLCLDTGHYAYCGGDSVEAIETFGERIGYLHLKQVDPRILAEVVAGGVPFGPAVERGVMCEPPSGVPALEPVLAAAQRLGVELFAIVEQDMYPCPPDRPLPIARRTRAYLRSCGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7P5</accession>
    <name>A0A0F4J7P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000616">
        <property type="protein sequence ID" value="KJY29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29783">
        <property type="protein sequence ID" value="KJY29783"/>
        <property type="gene ID" value="VR44_22095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.300"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470459" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="12984" checksum="4DBB430DDDDBA5D0" modified="2015-06-24" version="1" fragment="single">TAAAVAFSLATAPQAAASAGGCTASTGPGYVCVNVDGSGLRVNKGNVVRTKPDGICNYRAALVAKFPGKADTYYWGSYHNGCVYGRAYVDVTVQWTFADGVRICGYFYEGGNLQPGQPCVTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7V4</accession>
    <name>A0A0F4J7V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948994.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6639"/>
    <dbReference type="EnsemblBacteria" id="KJY30457">
        <property type="protein sequence ID" value="KJY30457"/>
        <property type="gene ID" value="VR44_20410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8792"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="28044" checksum="655A4DD5DB4E0C6B" modified="2015-06-24" version="1">MRAEPEPVVVELREDGRRAVLRTETLLVLALSLGASGVSALISFIGSLTKPGGLKDQAATLNGSYAPGRPWLDLAWQLFGIATALVPVLLVAHLLTREGAPGLRVLGFDRTRPGPDLARGALVAAAIGSAGLAFYLAARATGFNLTVVPEALPDVWWKFPVLILSAVQNAVVEEVIVLAYLLRRLDGLGWSPAAALLASSLLRGSYHLYQGIGGFLGNVVMGVVFVLAYRRWGRVGPLVVAHALLDIVAFGGYALLAGKVGWLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8P3</accession>
    <name>A0A0F4J8P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000654">
        <property type="protein sequence ID" value="KJY29326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29326">
        <property type="protein sequence ID" value="KJY29326"/>
        <property type="gene ID" value="VR44_23250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.590"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7129" checksum="2A96F8584F4433E4" modified="2015-06-24" version="1" fragment="single">ARRYAKRATRRSPPGSLISVVVPLVAGYSFILLRGPLLQASGRVAIAAMCLALVATYRTDKNTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Y2</accession>
    <name>A0A0F4J8Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30645">
        <property type="protein sequence ID" value="KJY30645"/>
        <property type="gene ID" value="VR44_19980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8617"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470733" evidence="1">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14287" checksum="4EB91E62733DDDB2" modified="2015-06-24" version="1" fragment="single">MPLTPFRTPSVYARRLRRAGRAGVLASAVALAALTSLVNAPAALASPPTPISAAEARAYLDTVTPVAEGSLTGYSRSLFPHWITISGTCNTRETVLKRDGVNVVTDSSCAAVSGSWYSEYDGATWTAASDVDIDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9H7</accession>
    <name>A0A0F4J9H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_19375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000531">
        <property type="protein sequence ID" value="KJY30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30855">
        <property type="protein sequence ID" value="KJY30855"/>
        <property type="gene ID" value="VR44_19375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8483"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="23188" checksum="150668FD1D333F08" modified="2015-06-24" version="1" fragment="single">AAPSPLLPLLVASPVVALPLAVSGVDLPLAGLCCLALAAAASGRPALAGVALGAACALKWTALPAVAVAAALLGSRRGARAAVRCAVVAGAVTAALVLPGALLQPGELWRQVFAFPTGRSEVATPAASPLPGHLLAELGPWGWYLTVALLGLGGLGVALSLWVRPPRTLVAAADRLALGLTLAFLLAPAARFGYLALPVLLVVWARSAAPAGAVPSRVVARSGRRGPRPAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAD0</accession>
    <name>A0A0F4JAD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VR44_19755</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948872.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000545.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3126"/>
    <dbReference type="EnsemblBacteria" id="KJY30708">
        <property type="protein sequence ID" value="KJY30708"/>
        <property type="gene ID" value="VR44_19755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8570"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJY30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="44528" checksum="517E0AA72881420D" modified="2015-06-24" version="1">MRTRPLKVALLGCGVVGSEVARIMTTHADDLAARIGAPVELAGVAVRRPSKVREGIDPALVTTDATALLKRGDIDVAIEVIGGIEPARTLITTAFENGISVVSANKALLAQDGAALHAAAETHGLDLYYEAAVAGAIPLVRPMRESLAGDKINRVMGIVNGTTNFILDKMDSTGAGYQEALDQATALGYAEADPTADVEGYDAAAKAAILAGIAFHTRVRLDDVYREGMTEVSAADFASAKRMGCTIKLLAILERAADGESVTARVHPAMIPLSHPLASVREAYNAVFVEAEAAGRLMFYGPGAGGSPTASAVLGDLVAVCRNKLAEATGPGESAYTQLPVSPMGDVVTRYHISLDVADKPGVLAQVATTFAEHGVSIDTVRQQGKDGEASLVVVTHRAPDAALSGTVEALRKLDTVRGVASIMRVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAM8</accession>
    <name>A0A0F4JAM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000599">
        <property type="protein sequence ID" value="KJY30011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30011">
        <property type="protein sequence ID" value="KJY30011"/>
        <property type="gene ID" value="VR44_21410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.158"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="5520" checksum="6D80DD2836C28DDE" modified="2015-06-24" version="1" fragment="single">FGVAWPPAALCAAAAAGAGTVTVLGPAPGPPALTLSCGLAATALAACTLRVLGRPARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAT6</accession>
    <name>A0A0F4JAT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30868">
        <property type="protein sequence ID" value="KJY30868"/>
        <property type="gene ID" value="VR44_19340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8475"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470889" evidence="1">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13079" checksum="7B93AEA17CAEE760" modified="2015-06-24" version="1">MRHLLPRRRPKVSASVSSLTSARVRAATLRTVSPRSAPSLSSRAATAAPSTWWLQCPAFMCQSSCPRITSWWSGAVRSSITTRSRSAMSSHRPLAVPCGKAAIRNCTGRPRCLLMPSQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAZ5</accession>
    <name>A0A0F4JAZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000587">
        <property type="protein sequence ID" value="KJY30151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949115.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000587.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30151">
        <property type="protein sequence ID" value="KJY30151"/>
        <property type="gene ID" value="VR44_21095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8942"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19922" checksum="C0F38DC862DF1AB2" modified="2015-06-24" version="1">MIINGVEMKGLAVAHAAGLADVLRRNRDHMAPYEPRRPEAFYTEAGQRARIEGMLEERDGGRLVPYVFTETATGAVVGAMNLGGIARGPLCSGGVGYWVDRAWHGKGLATAGLREVCRTARDELGLHRIEAQTLVDNTASMRVLAKAGFTEIGLAPRYLHIDGAWRDHRLFQRLLHDDPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB11</accession>
    <name>A0A0F4JB11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000484">
        <property type="protein sequence ID" value="KJY31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2221"/>
    <dbReference type="EnsemblBacteria" id="KJY31547">
        <property type="protein sequence ID" value="KJY31547"/>
        <property type="gene ID" value="VR44_17915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8127"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="28" mass="2827" checksum="A6A3422ED16E3025" modified="2015-06-24" version="1" fragment="single">STQAKGDESLSHILDNIPVLSGNLSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBM1</accession>
    <name>A0A0F4JBM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30381">
        <property type="protein sequence ID" value="KJY30381"/>
        <property type="gene ID" value="VR44_20680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="17687" checksum="AF8E3C07E8C00ABE" modified="2015-06-24" version="1" fragment="single">MTDRNPASAAPRPHRHHWRRDLVELAALFCAVAVADGIANLVAHGPSGPLLLVASAVALLVTAGFHTWWARRHSHAPPPGAALPSDRPAAAPEAAPTTPATPAVGALWRMRTTVRDEPGSLASLCTALARAQVDILTLQTHPLPEGGTVDEFLLRAPRDLAIADLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCC7</accession>
    <name>A0A0F4JCC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948575.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31413">
        <property type="protein sequence ID" value="KJY31413"/>
        <property type="gene ID" value="VR44_18180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8183"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="31086" checksum="2F795EE3C6259135" modified="2015-06-24" version="1">MAEQDPSAPVRFMDLTDPRYAYMFGFLQADGHLSQGRGQKGHLTAEINARDIHILREFQQLTPYHSSITERVRSTNFAEMHHSATWTVCSLEARTIVNGLGIPYGKKSLSIKPPRTGFSRPDYVRGIIDADGSLGWTAQGFPFLSLTSASTAIAAYLCHYGKKITGTERTISRNQRDGVYNVCYYKETAQQLAAHLYYDGCLALDHKKARATSIQAWVRPAGMRVAPPRRRWTAQDDRELVRLDDPAAAAVVLERTEQSCAMRLWRIRTGRVALAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCD8</accession>
    <name>A0A0F4JCD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948907.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000550.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30641">
        <property type="protein sequence ID" value="KJY30641"/>
        <property type="gene ID" value="VR44_19950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8610"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14516" checksum="5B1205CA7776E2B1" modified="2015-06-24" version="1">MSEHPDCALIRRGYEAFGKGDMETLGGMMTADVIHHVPGTSPLSGHHKGREAVLDLYRRMAEETKGTLRVTLERVLVDGRGHAMSFHTTMADRGDRGIEIHEGLFFTIVGGKITDIDQCTQDIDESDAFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCJ1</accession>
    <name>A0A0F4JCJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_17975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31524">
        <property type="protein sequence ID" value="KJY31524"/>
        <property type="gene ID" value="VR44_17975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8140"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="32022" checksum="07665FB566E906A7" modified="2015-06-24" version="1">MVVVLFGATVILFCCLFVLPGDPVGSLGGDKARDPAVVEALRERYGLNDPLPVQYGNFVKNLAQGDLGEDYTQRRPVTEVLAPKLTNTAELALAAIVLDILIGLLAGLIAALFRYSFWDVLITLLTTMAVGFPSFVIGMVLQKVFVVQFKWFPLISDGTMNSLILPAFTLAILDAALVARLMRGTMLEVLRADYVKTAVAKGLPRRTVLVKHVMRNSIIPVVTYLGISFGSLLGGALITEAIFNWDGIGLALVQAVQQQNNPIIIGVVSFGVAVFVLLNLLVDLLYAVLDPRIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCL4</accession>
    <name>A0A0F4JCL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948546.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000491.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31473">
        <property type="protein sequence ID" value="KJY31473"/>
        <property type="gene ID" value="VR44_18025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="12574" checksum="D266A0B2C56DF990" modified="2015-06-24" version="1">MSSDYPFADGYNLLWDLTGFGDADEEIVESVSLSRDQYLRIRHLFVLGDDPWMVAGEYRVAPSIWAHVRRAVPGVRFERDADYFLGARQALPDGRFWRPAPGVAAPGPIPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCT9</accession>
    <name>A0A0F4JCT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000434">
        <property type="protein sequence ID" value="KJY32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948253.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32172">
        <property type="protein sequence ID" value="KJY32172"/>
        <property type="gene ID" value="VR44_16455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7689"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="36222" checksum="F48E65812527D580" modified="2015-06-24" version="1">MLESIGLENRDRDVYRALLVHPDWDMQDIAQNLGMDEAEVRETLDRLTGFSLLRSTSGAEPLVPASPELGLLPLLQVMEAELDEHRARLSRDRAMLTALTSEYTARRVQNDVAGVERLVGLEAVRSRLSQLAREATSEVRAFMPGPALSQAALDASRPLDVQNLARGVRMQTVYLETVRKDPATVEYATWFAQQGGQTRTMPSLPMRLILCDRSVAVLPVKPDASEQGAFVIRLTSIVTALNQLFDLTWERATPLGEPSVLPCDGPSERELALLRMLEDGHTDEVVARKLGVSIRTVRRLMADLLKTLNAESRFQAGVQATRRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDW6</accession>
    <name>A0A0F4JDW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32537">
        <property type="protein sequence ID" value="KJY32537"/>
        <property type="gene ID" value="VR44_15765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7559"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6781" checksum="099D820D65CE9C83" modified="2015-06-24" version="1">MEIIWRKSSRSADTGNCLEVAVQDGEILIRESDDPSVIIRTSRAKLRAFIDGAAAGEFDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JES6</accession>
    <name>A0A0F4JES6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000420">
        <property type="protein sequence ID" value="KJY32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948203.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000420.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32309">
        <property type="protein sequence ID" value="KJY32309"/>
        <property type="gene ID" value="VR44_16195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7604"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11564" checksum="574355898779BC5D" modified="2015-06-24" version="1">MRFDSVSSPAALARMDALSRCLTPSTGHVPSLWPRVTVCMPEAADGLDAAGSLTPEQSLLGVLLDDDQPPFQQALLTWLEEYSRVRSRCPPRPPLGVPDARPDGGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JET4</accession>
    <name>A0A0F4JET4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000397">
        <property type="protein sequence ID" value="KJY32710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948049.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000397.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32710">
        <property type="protein sequence ID" value="KJY32710"/>
        <property type="gene ID" value="VR44_15370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7476"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YkuD" evidence="1">
        <location>
            <begin position="60"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24585" checksum="359D485A16ADAB8E" modified="2015-06-24" version="1">MRNALVAGSLVLAGLWPHGPAPLPERLADTGGGSQLIIAVAPAPGSTTGLLTWWDRRAGRWYEAGRAPARFGANGLTEGATRTQGTNTTPTGLYDLPYAFGIARAPAGTQYAYRRVTDRSWWCQDNASTAYNRWTEPLPADCAPGESEHLVAYERQYAHALVVGFNYERPVRGRGAGIFLHVDGRGATAGCVSVPEGAMRELLRWANPRRAPHIAIGTEDGPLSVTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEX5</accession>
    <name>A0A0F4JEX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S Mo/W bis-MGD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000419">
        <property type="protein sequence ID" value="KJY32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32318">
        <property type="protein sequence ID" value="KJY32318"/>
        <property type="gene ID" value="VR44_16175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6887" checksum="7579FBD1653183E7" modified="2015-06-24" version="1" fragment="single">MAEEDVDTWVRAASLLHSGGDAMDIAVRHGRIVGVRGRPGDRVNRGRLEPKDLYAWQANASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF74</accession>
    <name>A0A0F4JF74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000388">
        <property type="protein sequence ID" value="KJY32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948013.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000388.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32860">
        <property type="protein sequence ID" value="KJY32860"/>
        <property type="gene ID" value="VR44_15160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7451"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470890" evidence="2">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="446" mass="47227" checksum="7F9D4A63D7F6221A" modified="2015-06-24" version="1">MAVSLAAGVLFTTGTASAGERAGTSQAGGDVYGTKTPYAPQGRPGRYENAPNGFVPVFTETVARHGSRAMTDSGDGDAVLAVLHRAQDQGALTGLGTRLGPQVRSLLDAASALGYGNLSARGAEEHRQTALRLEQRLPGLVAGIAARHESITVETSGVPRAVASADAFTGGLTAGDPALAGLIKAPVTDKNLLYFHKQPQNADYQAYVKSDPQLATVLTGIDGDPRTAEAAQRVAARLFRQDFVSALSAEAQISFARSLHQLHSAAPDLAVEAPDVDLTPFLTRRDAQWLAYLDDAEEFYQKGPGFSGRTITYKMAGVLLDDLLAQAQAKAAGTNGNGAVLRFTHAEEIEPLAALMGLPGSTEPAEPGQPYAYGNNPWRGAEVSPMAANIQWDLFANTPAEGRRATYLVRMLYNEKETAFKPSCRPVATGSYFYELDELTHCLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFB3</accession>
    <name>A0A0F4JFB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen alpha-5(VI) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_15015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947977.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32905">
        <property type="protein sequence ID" value="KJY32905"/>
        <property type="gene ID" value="VR44_15015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7422"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="500" mass="52506" checksum="27F62FAD78CD10D7" modified="2015-06-24" version="1">MRGRGPGAEHDRVTETIPGLYLSLPELLVLLGAVVLLVARRLPPARRRSGTLVAGAVLVPSAVVLGVVGVRWQMLPVLAGAAVASVFALPPLLRRRTGRPARRTRWWPALLGSLACAGLIATGPVAAWAFPVPVFPEPTGDFAVGTRVVQWTDPLRPESFTADPDDRRTVVVQLWYPAPKSPAGVPRAQYLGRTREEARAVAGALADGFGLPGFLVDGLPRARSRAVFDAPVAGGKERFPVVLFSPGSGGVRSQNTAWAEELASHGYLVAALDHPYDSTVVVLSDGRAIRTATASSGDRDRDAELAVGWTAVRAADLGFVLSRLERLDRGETADPLAGRVDTGRAAVAGHSLGGAAALQAARQDRRFGAVVDLDGYPHGPTTPALRQPALALTQEFTAGTDPRYLPRLTEALDHNTAKSYRLTVPGAAHLTFMDGPLYLPPVSSLVGTLGRTEGPRLVAAATLAFLDATLRGRPGDPADTLRAYGTVSSSGARATATPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFG7</accession>
    <name>A0A0F4JFG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000407">
        <property type="protein sequence ID" value="KJY32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948129.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32544">
        <property type="protein sequence ID" value="KJY32544"/>
        <property type="gene ID" value="VR44_15800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7567"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="18052" checksum="280230BDE6DE3EE2" modified="2015-06-24" version="1">MRAGRPAVLRGRASAAADMADAVGELYSSDAEDAVLVWNGVPVRLSYAHDLAALLDDLVPLLEEVRRPEFSETEVFWGSDTFSAEWRIVREGDSLRIRARWHSTLGNHESLLAERGDPVVPAQVFSREWAKLLRRIVTDIEAEAVELQDDDIFLRAKALLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK4</accession>
    <name>A0A0F4JGK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948287.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000439.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32096">
        <property type="protein sequence ID" value="KJY32096"/>
        <property type="gene ID" value="VR44_16650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7763"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="55"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="484" mass="54173" checksum="05794C6362E56E97" modified="2015-06-24" version="1">MRQFPLEMHQVAPGRLVEWRLRSTTAPGAADRRASFNQDKHFTVAEESRADGDRVASWVAVTFEVDGVLDEPLLARALLGFVQRHEVLRCEFLRLAGEVSCAPLPAGELALDAVEVAAHGSAGRLGAFLSERFQRSIDTLSWPLFVMGAVVRPESSTVYLAFDHIVCDGMSMPVVAHQVLTAYEALVRGEEPELPPAPSYLDFADEQRRRYLSIDADDARLGYWKSFIERGGEFFPRCPLDLGVEPGRMYPIVNEASWLLDAAEAEVFEKVCRETGAKPFMGLLASVAVCLREAGGPGVYRGFMPVSERGREKWTDSVGWFVNTLPIEFDASPGKDFAQVVAGVGEGFREMMRHLDVPFVRAWELLAPEEFALRSWPYAVNFFSYIDMRRCPGAERHEEWRPTTHVWSATGNGTCSWFQRDADGLHMNSLYVDTPAARRTMDDFQEALRRTVQCVARTGGFRRPVGLTAPRRPEPDPRAARVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGS0</accession>
    <name>A0A0F4JGS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000434">
        <property type="protein sequence ID" value="KJY32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32171">
        <property type="protein sequence ID" value="KJY32171"/>
        <property type="gene ID" value="VR44_16450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7688"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="112" mass="11971" checksum="81722A7BD39403F9" modified="2015-06-24" version="1">MPVYAIKVLLQSPYDARTTGARSSADIGERILVDPQPGIAHVSLVPLSSQVVAMTFVVAADLGAAERLAAEAWDTWLGREWSADWKMSSCGADLLLGVWAAAEPFVQETGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH05</accession>
    <name>A0A0F4JH05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ORF">VR44_14670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947922.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5615"/>
    <dbReference type="EnsemblBacteria" id="KJY33033">
        <property type="protein sequence ID" value="KJY33033"/>
        <property type="gene ID" value="VR44_14670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7261"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="277"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="38908" checksum="521C14B026ED1C05" modified="2015-06-24" version="1">MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNIGVVGVPDKRLAVLAGIFGSQRILPATVDFVDIAGIVRGASEGEGLGNKFLANIRESDAICQVIRAFKDENVVHVDGKVSPKDDIETINTELILADLQSIEKAIPRLTKESRLQKDKVAVLAAAEKAQKILENGDTLFSQGITKGTEQGDLLHELHLLTTKPFLYVFNVDEDELTDDAFKAEQSALVAPAEAIFLNAKLEADLAELDDEEALELLQSVGQDEPGLATLGRVGFATLGLQTYLTAGPKETRAWTIKQGATAPEAAGVIHTDFQRGFIKAEVISFADLVECGSVAEARAKGKARMEGKDYVMQDGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHD5</accession>
    <name>A0A0F4JHD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33605">
        <property type="protein sequence ID" value="KJY33605"/>
        <property type="gene ID" value="VR44_13665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7009"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7645" checksum="2217B1E9F16D949F" modified="2015-06-24" version="1">MTVRDMVVRLCAAFPSVDAATVETTVRAEYDGFREARIRAFIPILVERRARRALSAASEQMQMPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHK9</accession>
    <name>A0A0F4JHK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947714.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000345.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3028"/>
    <dbReference type="EnsemblBacteria" id="KJY33690">
        <property type="protein sequence ID" value="KJY33690"/>
        <property type="gene ID" value="VR44_13505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6952"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27116" checksum="3BE2F457A089D4BC" modified="2015-06-24" version="1">MTLSLEVSEGVGTIRLDRPPMNALDIATQDRLRELAVEATDRADVRAVILYGGEKVFAAGADIKEMQTMDHAAMVARSRGLQEAFTAVARIPKPVVAAVTGYALGGGCELALCADYRIAADNAKLGQPEILLGLIPGAGGTQRLSRLIGPSRAKDLIFTGRMVKAEEALTLGLVDRVVPAAEVYEQAHAWAAKLAQGPAIALRAAKECVDAGLEADIDTGLTIERNWFAGLFATEDRERGMRSFVEEGPGKAKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHU7</accession>
    <name>A0A0F4JHU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000338">
        <property type="protein sequence ID" value="KJY33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947678.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000338.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33780">
        <property type="protein sequence ID" value="KJY33780"/>
        <property type="gene ID" value="VR44_13310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6884"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12680" checksum="5C5A6815E1BA11E2" modified="2015-06-24" version="1">MSLAVPMDTAAEDVRWVRDCLDRGLLTGADVIRHKVPACWALDEDQWLGDIGHPDRHDRPAAVLAARAEADRLFDAALGGDPEAWWRAARALPDFAGTLPELLARVTDGDSVSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI19</accession>
    <name>A0A0F4JI19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_15690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948107.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32606">
        <property type="protein sequence ID" value="KJY32606"/>
        <property type="gene ID" value="VR44_15690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7540"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="6">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="7">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24358" checksum="8A189C7CBF0B953A" modified="2015-06-24" version="1">MTGDSEFHEVLHSLRVWDTALPSFDPASAPAEPLELFREWFVHAARAGQVEPHTMSLATVDADGRPDARILMLHDADARGWHFASHATSAKGRQLAGGPEAALVFYWPAVGRQVRVRGRVTACGERESRADLAVRSRGALAAALTGRQSEVLGSREELAEASAAAWERAGAEPDAPAPTWTRYVLEPLEAEFFQGDAARRHVRLRYRRAEGSGWTRELLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIA8</accession>
    <name>A0A0F4JIA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="13" type="ORF">VR44_15365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000397">
        <property type="protein sequence ID" value="KJY32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000397.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3273"/>
    <dbReference type="EnsemblBacteria" id="KJY32706">
        <property type="protein sequence ID" value="KJY32706"/>
        <property type="gene ID" value="VR44_15365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7475"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="11">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="12">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19690" checksum="F433DFCAE9BAC67E" modified="2015-06-24" version="1">MSQAQEHEQNGGPSVPQTRTARHRRIVDILNRQPVRSQSQLAKLLADDGLLANDGLSVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGFRTPQAPLGESAKEERMRRLSGELLISAEASANLVVLRTPPGAAQFLASAIDQAELHAVLGTIAGDDTLMLISRDPSGGQALADHMLRLAQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIW3</accession>
    <name>A0A0F4JIW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000312">
        <property type="protein sequence ID" value="KJY34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947540.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000312.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34125">
        <property type="protein sequence ID" value="KJY34125"/>
        <property type="gene ID" value="VR44_12565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6577"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="28351" checksum="4D32BC846DA0EDB7" modified="2015-06-24" version="1">MNVRTQDGSAGHVGHAAAGYGRSAFRRPDTRIARFIAEALGDARTVLNVGAGAGSYESAAREVTAVEPSRSMRDRRPARLVRAVDAVAEDLPFADGEFDGAMTLFSVHQWSDVTRGLREMRRVTRGPVVVLTCAPSLVRDFWLYEYAPEVLDTEARRFPRVEDIAAALGGTGTVHTVPIPLDCTDGFNEAYYGRPEMLLDPGARQACSAWSFVDDGVRERFDQSLRRDLASGAWDARHGHLRTQRTYEGSLVLVRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKG6</accession>
    <name>A0A0F4JKG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_12150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000298">
        <property type="protein sequence ID" value="KJY34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947461.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34319">
        <property type="protein sequence ID" value="KJY34319"/>
        <property type="gene ID" value="VR44_12150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6518"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471132" description="D-alanyl-D-alanine dipeptidase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="30444" checksum="04403F475BB2D4C3" modified="2015-06-24" version="1">MTTSTPARFAVAVAAAAVFAMTTAPGAGAVARAPEPRAPREFVALDSVDPTIIQEMRYLSAHNFVGERIDGYRQPVCILTRPAAEALHRAQTHLLRQGYSLKVYDCYRPQRAVDHFVRWAKDLADERKKAEFYPRVDKSRLFEDGYIAEKSGHSRGSTMDLTIVALPALPAPPPRPGQESVPCYAPQAQRYPDDSVDMGTGFDCFDTLSHTDDPRVQGAQRAHRLLLRTALAAEGFVNLPEEWWHFTYKPELFPDTYFDFPVSRRSVAGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKK1</accession>
    <name>A0A0F4JKK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947788.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000355.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33471">
        <property type="protein sequence ID" value="KJY33471"/>
        <property type="gene ID" value="VR44_13915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7069"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="36252" checksum="D324A2FC495AA185" modified="2015-06-24" version="1">MPSPTTPLVPEPVRRLAAWCAVVLLAAGVVGIGVWLCVVFRTAVTPVLLALLGTALLGPLHRRLVRMGMRRSLAAVLTCLAVVAVAGGAAYIVATALIKTGDQILGALKQAGQELAEHFGAAGASVRDLAAHAQGLLARLGGTAASGLLSSLGAVGAMTATSVLALLLMFFFLRDSDRAADALRSLAPRSTGDVVEAMARRAYGAVEGFMRGTTFIAAIDAVCITAGLLVLRVPGAVGLGALVFVGAYIPYLGAFVSGSVAVLVALADRGWAIALWTLGVVLAVQMLEGHVLLPMVQSRTVQMHPATVMVAITAGAGVAGVLGMLFAVPLTAAVSGVVSEIRARYAEPAAGPGPESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLR9</accession>
    <name>A0A0F4JLR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000329">
        <property type="protein sequence ID" value="KJY33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947620.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2314"/>
    <dbReference type="EnsemblBacteria" id="KJY33906">
        <property type="protein sequence ID" value="KJY33906"/>
        <property type="gene ID" value="VR44_12995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="282"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="37179" checksum="6003BCA61377FC16" modified="2015-06-24" version="1" fragment="single">MSTEAYVYDAIRTPRGRGKANGALHGTKPIDLVVGLIHALRERNAGLDPATIDDIVLGVVGPVGDQGSDIARIAAIAAGLPDTVAGVQENRFCASGLEAVNLAAAKVRSGWEDLVLAGGVESMSRVPMASDGGAWFADPMTNWDTGFVPQGIGADLIATIEGFSRRDVDEYAALSQERAATAIKEGRFAGSVVPVTDRNGLVVLDHEEFVRPGTTADTLAKLKPSFADIGDLGGFDAVALQKYHWIEKIDHVHHAGNSSGIVDGASLVAIGTREAGERNGLRPRARIVSAAVSGSEPTIMLTGPAPATRKALAKAGLTIDDIDLIEMNEAFAGVVLRFVKDMGVSLDKVNVNGGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLS6</accession>
    <name>A0A0F4JLS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R2K_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000232">
        <property type="protein sequence ID" value="KJY35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947147.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35297">
        <property type="protein sequence ID" value="KJY35297"/>
        <property type="gene ID" value="VR44_10440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5830"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025643">
        <property type="entry name" value="R2K_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14243">
        <property type="entry name" value="R2K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R2K_3" evidence="1">
        <location>
            <begin position="142"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="32304" checksum="A422F0CEB530AC2A" modified="2015-06-24" version="1">MPMPVLYCRDAFNPRRVDEHFAPEAREVRACGGAVALIDHDALLRGDAREAVAQVPAGLGRAWYRGWMIPSDRYAALAEALNRRGTELVVTPEQYRKSHELPGWYAMFAEVTPASVWRPTEPGGMVTAEDLAALAASLPSGAGIVKDYVKSRKHEWEQACFVPDLADAVGLTRIVRRFVELQEEFLAGGIVLRAFEAFSRLESVAAEVRVWWLDGEPRWLTPHPDSPFGRGLVPDLDHVRPAVRRLGCRFVTTDVALRTDGVWRVVEVGDGQVSDLHRSSSRAELAALLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLV8</accession>
    <name>A0A0F4JLV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000261">
        <property type="protein sequence ID" value="KJY34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947293.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000261.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34809">
        <property type="protein sequence ID" value="KJY34809"/>
        <property type="gene ID" value="VR44_11245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6260"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8744" checksum="F13B8E6F6F3A5BA5" modified="2015-06-24" version="1">MNCNDFVELVTEFLDGALSEGDERRFIEHLAECSGCETYLDQFRQTIATTGELTPDGISSDARQHLLSAFRDWQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMZ6</accession>
    <name>A0A0F4JMZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000298">
        <property type="protein sequence ID" value="KJY34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947458.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34316">
        <property type="protein sequence ID" value="KJY34316"/>
        <property type="gene ID" value="VR44_12135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6515"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6875" checksum="84420A8E8DCF8327" modified="2015-06-24" version="1">MKDPFACEEPALLARTGTADRAAARRAVASRATDGEDLRELLDMLGLRPADDPPAGRERRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN65</accession>
    <name>A0A0F4JN65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947426.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34381">
        <property type="protein sequence ID" value="KJY34381"/>
        <property type="gene ID" value="VR44_11960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6477"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="44411" checksum="EBF5FFE84C2678EC" modified="2015-06-24" version="1">MGSGRWRGHPRGHRLGRPFGRLWAAYGTSALGTWLAFGAFPLIAVRVLHAGPAEVAALSSAGAAAGAVAAVPLGPWAESRRKRPVLVAMDLLRCAALLTVPAAFALGALTFLQLLLVSVVVATADITFRAASGAYLKTLLPAGDLLAANARLESTAWTTTIAGPPLGGALTGLLGPVATVVADAASYLLSALAIRATGGHEPPPRRPETGRPRARDLLEGWRFVLADAGLRPLLFNAALFNGLVMATSPLLAVLMLGPLGFEPWQYGLAFAAPSVGGLLGSRLARPLVTRYGQHRVLTVSGTLRALWSVGLAFVGPGTGGLLLVTGVEFGLILCCGVFNPVCATYRLERTPSGRVTRTLSAWAVTTKAATALLTALWGVLGTLLGPRPALALAGVLLLATPLLLPRRPPPAPDPARGRAHGFKDGTAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPK7</accession>
    <name>A0A0F4JPK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ORF">VR44_08465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000177">
        <property type="protein sequence ID" value="KJY36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946775.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene929"/>
    <dbReference type="EnsemblBacteria" id="KJY36115">
        <property type="protein sequence ID" value="KJY36115"/>
        <property type="gene ID" value="VR44_08465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4756"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="13288" checksum="4BCDA233E30ACAFE" modified="2015-06-24" version="1">MNAYAPILVLGAIGAGFAIFSVVMATLIGPKRYNRAKLEAYECGIEPTPMPAGGGRFPIKYYLTAMLFIVFDIEIVFLYPWAVTFDSLGIFGLVEMLLFVLTVFVAYAYVWRRGGLEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ17</accession>
    <name>A0A0F4JQ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946696.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000056_gene605"/>
    <dbReference type="EnsemblBacteria" id="KJY36452">
        <property type="protein sequence ID" value="KJY36452"/>
        <property type="gene ID" value="VR44_08055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4438"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="42882" checksum="72193A22EBD0DA80" modified="2015-06-24" version="1">MTAIDPTAHLTAEQIEELGRELDAIRDEVIAGRGEKDAAYIRKVISAQRKLELVSRGVLLFSFFPPAWLIGTAGLSVAKIMDNMEIGHNILHGQWDWMRDPKIHSTTWEWDHVSPADQWKHSHNELHHTYTNVLGKDNDLGYGIMRVDEDQKWHPFHLGQPLWNFINACFFEYGIAAYDLELGKNLRGRRRKDPEFRTRARAVGRKIRKQVLKDYVIHPLLSGPSFLTTLAATFTANLVRNIWTHSVIMCGHFPEGVQVFERRSIKDETRGQWYLRQMMGSANISGSRAMHFMTGNLSHQIEHHLFPDLPSNRYAEVAVKVRALFEKYELEYVTGPLPKQVFSAWRKVFRLSLPNRKPTVEAPEREPELVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQY4</accession>
    <name>A0A0F4JQY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946636.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36590">
        <property type="protein sequence ID" value="KJY36590"/>
        <property type="gene ID" value="VR44_07720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4156"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14723" checksum="FB1EF636CE714465" modified="2015-06-24" version="1">MSAVREGLPEGRYGRSADERADRKLKVVGSVLGVGLLAVVGWIGWDYVGGQSVSAEVIKFQIVSDSEVKVHLEVRKDASVTGVCTLDSQDQDHGEVGRADFTFPQKTTRVDEVVTLKTTGRATMVELVGCQEAGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRJ7</accession>
    <name>A0A0F4JRJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydroxybiphenyl 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946693.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36449">
        <property type="protein sequence ID" value="KJY36449"/>
        <property type="gene ID" value="VR44_08035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4433"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="42210" checksum="103C7920664CDEC9" modified="2015-06-24" version="1">MSETRADAVGVPDVRTAHQDLHSAQGALRGEHPGRSRNPVIKVADLAWLEFEKPDLDRAEVFARDFGFGIAARSGSELWLRGTFAGSPCMVIRRGRTSRFIGPAFRAAERADLDRLARATGASVRDADVPGGGKAVDLLDPSGFPVRVVHCTEELPALPEQQPLLLNFGTGHRRTNVAQRPPREPSRIQRLGHVVLETRVFGRALDWYLDTLGMIVSDFLFLDGQRGRGPTMAFIRCDQGGRAVDHHTLAMHLGPGNGYVHSAYQVTDLDSIAAGGEYLAERGYQRSWGIGRHIQGSQLFDYWRDPDRFMLEHFADGDLFSCDLEPGWAPMSTSGLAQWGPPATRDFLGASPSPQRVRDVIEALRGENEMDPARLLGLLKAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRX2</accession>
    <name>A0A0F4JRX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946630.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5531"/>
    <dbReference type="EnsemblBacteria" id="KJY36584">
        <property type="protein sequence ID" value="KJY36584"/>
        <property type="gene ID" value="VR44_07690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4150"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="42522" checksum="DDE78DF3DAB092E3" modified="2015-06-24" version="1">MTYRVQPVPQVILDDVRGAQKMLSGVSRVTAMEGSRHLTSLVGAPVHLKCENLQRTGSFKLRGAYVRIAGLRPEQRAAGVVAASAGNHAQGVALASSLLGVRSTVFMPVGAPLPKVAATQEYGAEVRLEGHVVDETLAAAQEYADRTGAVFIHPFDHRDIIAGQGTVGLEILEQCPEVRTILVGVGGGGLAAGVAVAVKALRPDVKVIGVQAAGAAAYPPSLQVGHPVSVDRPVTMADGIKVGRPGDVPFAIIGELLDDVRTVSEDALSSALLLCLERAKLVVEPAGCAPVAALLSEPERYGGGPVVAVLSGGNVDPLLLQRILRHGMAAAGRYLSLRLRVADAPGALAGLLGVLSTVDANVLDVSHVRTDPRLGLTEVEVELHLETKGPEHCKEVARTLHAAGYRVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT06</accession>
    <name>A0A0F4JT06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946797.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36091">
        <property type="protein sequence ID" value="KJY36091"/>
        <property type="gene ID" value="VR44_08575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4857"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="67"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="38410" checksum="E704E70129AA6862" modified="2015-06-24" version="1">MTEVTDAPTLLSLVPKAEAKQSMKDFKSDQEVRWCPGCGDYAVLAAVQGFMPELGLARENIVFVSGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLATSRRDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQYSPTSELGKITKSTPMGSLDAPFNPVSLALGAEASFVARTVDSDRKHLTEVLRQAADHPGTALVEIYQNCNIFNDGAFDALKDKDQAEEAVIRLEHGQPIRFGAGLTKGVIRNERTGDLEAVEVTAENEARILVHDAHAASPTTAFALSRLADPHTLHRTPIGVFRDVQRPVYDTLMADQLETAVDQRGKGDLGTLLAGSDTWTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUD8</accession>
    <name>A0A0F4JUD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946119.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37795">
        <property type="protein sequence ID" value="KJY37795"/>
        <property type="gene ID" value="VR44_04925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1072"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="32845" checksum="4D7E75B05DA51550" modified="2015-06-24" version="1">MPDSTHLWMRHEARPTERRAPLTPQDAARLVEAGVRITVEESAQRAFPLADYTAAGCATAPTGSWHEQAPDEAYVLGLKELPAGPGAPALRHRHIYFGHAYKGQAGARELLARFTAGGGALLDMEYLTDEAGRRVAAFGYWAGYVGAALAVLHHRGALTAPLVPTDRPALDALLAHDLLVNTVLTTTPVPPFLTKADLDEPARRLSLVSDVTCDVTSDCNVLPVYDETTTWDAPVRTLRDGDRPLDLIAIDNLPSLLPVEAATAFSAELAPHLLRLAEWDGVWARALHSFRTAVESQEAAPFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUU8</accession>
    <name>A0A0F4JUU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000103">
        <property type="protein sequence ID" value="KJY37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946238.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000103.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37518">
        <property type="protein sequence ID" value="KJY37518"/>
        <property type="gene ID" value="VR44_05560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1925"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="16437" checksum="7A61C31295436C70" modified="2015-06-24" version="1">MTAGAFAGPVAGAVAAADLGMPPFAPGDFAVLEVWPKSAVPGTTVTVNTKACGPGSHAEGDATTVGGGRFKLTPGTHKEVVAGQFQVARDIRPGTYGIGATCADGKFATGDLVVTEHGPQGHVRTGVGGGTTTTAADPAKITAGAAVLAAAAVGGTWLLRRRASGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVE6</accession>
    <name>A0A0F4JVE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine/betaine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_05100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946151.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene156"/>
    <dbReference type="EnsemblBacteria" id="KJY37723">
        <property type="protein sequence ID" value="KJY37723"/>
        <property type="gene ID" value="VR44_05100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1335"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="262"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34016" checksum="F9AADDC52AE8795A" modified="2015-06-24" version="1">MIRFEHVTKRYPDGTTAVEDLSFEVAEGELVTLVGPSGCGKTTTMKMVNRLIEPTSGRILLNGEDVSAADPVELRRRIGYVIQQVGLFPHKTVLENTATVPQLTGTPKAKARARAAELLELVGLDPAVFGSRYPEQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVRERLQNEFLALQKTVRKTILLVTHDLEEAVRLGDRIAVYGEGTIEQFARPAAVLGAPATDYVASFVGADRGLKRLAVTPVGEADLTAAADGEEPAATVALGASLREALAALLQQDAGRIGVTDPDSGALVGVLTPEGVHRALRRAEPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK6</accession>
    <name>A0A0F4JVK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="6" type="ORF">VR44_03775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945911.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene784"/>
    <dbReference type="EnsemblBacteria" id="KJY38402">
        <property type="protein sequence ID" value="KJY38402"/>
        <property type="gene ID" value="VR44_03775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8658"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="4">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="5">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="34127" checksum="AEE123943D7AB2D0" modified="2015-06-24" version="1">MKGTVGELGEFGLIRELTSRLTTTPAVRLGPGDDAAVVSAPDRRVVASTDILLEGRHFRRDWSTAYDVGRKAAAQNLADIAAMGAVPTAILLGLVVPAELPVTWPTELMDGIRDECQVAGAAVVGGDVVRGDTITVSITALGDLRNHEPVLRSGAQPGDVVAVTGWLGWSAAGYAVLSRGFRSPRAFVEAHRRPEPPYHAGPAAAGLGATAMTDVSDGLIADLGHIAEASHVRIDLRSGAVDIPTQMHDIGQAVGVDPLQWVLTGGEDHAIVATFPPDVKLPARWKVIGEVQHRSALPQVTVDGAPWTSTGGWDHFGTDPATEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVV4</accession>
    <name>A0A0F4JVV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37101">
        <property type="protein sequence ID" value="KJY37101"/>
        <property type="gene ID" value="VR44_06555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3227"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10791" checksum="72DE00617B5F8577" modified="2015-06-24" version="1">MPPGAPRTAPGRSLRRRSGTSPPTGSTLGPSPAARSQPARFRSPGAPRSARSPRTRRCRRSPRSLTRTRSTAAATDSTARASPATSSTSPRARRATCPRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW31</accession>
    <name>A0A0F4JW31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042811540.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6601"/>
    <dbReference type="EnsemblBacteria" id="KJY38572">
        <property type="protein sequence ID" value="KJY38572"/>
        <property type="gene ID" value="VR44_03305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7877"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24528" checksum="C30BBA59C8F00FE0" modified="2015-06-24" version="1">MDDVLRRAPLFAALDDEQAAELRASMGEVTLARGDALFHEGDPGDRLYVVTEGKVKLHRTSPDGRENMLAVLGPGELIGELSLFDPGPRTATATALTEVKLLGLGHSDLQPWLNARPEVATALLRAVARRLRKTNDQMSDLVFSDVPGRVARALLDLSRRFGVQSEEGIHVVHDLTQEELAQLVGASRETVNKALADFAGRGWLRLEARAVILLDVERLAKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW49</accession>
    <name>A0A0F4JW49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945905.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38395">
        <property type="protein sequence ID" value="KJY38395"/>
        <property type="gene ID" value="VR44_03735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8650"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8557" checksum="F6EA10BFDCA95309" modified="2015-06-24" version="1">MERDSQLELYELVADRLKEAHARVRTLQVPEGVRMALSRKLLVVTAAAKHDLADAARRLDRLMKDLDEGRFPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW61</accession>
    <name>A0A0F4JW61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38405">
        <property type="protein sequence ID" value="KJY38405"/>
        <property type="gene ID" value="VR44_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="25173" checksum="399B2C9A08854FD5" modified="2015-06-24" version="1" fragment="single">MAHEPEPQPADEFDAGAVRTWSSLALAALGRARTDIDAINVYPVADADTGTNLYLTAESADRALTGALARTAPGVTDGTAPDTAASLPEAVRAYAHGALIGARGNSGTILAQLLRGVADVLGADPAGRAPGPLLAEALTRAAEEAYQAVAHPVEGTMLTVAGAAARAAQAAPGTAADVARAAYEGARAALAETPGQLAALGRAGVVDAGGCGLVAVLGALWQALSGQEPEPDPVQAPAVPVERLPEPCAQEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWT6</accession>
    <name>A0A0F4JWT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946252.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37421">
        <property type="protein sequence ID" value="KJY37421"/>
        <property type="gene ID" value="VR44_05650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1945"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471318" evidence="5">
        <location>
            <begin position="32"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="323" mass="34258" checksum="9C2C6D9F7E54EFE2" modified="2015-06-24" version="1">MNVRRLIPTAALAGAVALAGTALTACSEAGAAGADKDGGLSVTASFYPLQFLAEQVGGDHVKVDTLTKPGVEPHDLEITPKQTGRLGESNVVLYLKGLQPAVDKAVAQSGVKNIVDAATLTKLEVHGTSGEEDHDHAAEGHDHGHDHGENAEDPHVWLDPVKYAEIAKGFGAAMEKADPEHAADYRKNTDGLVAKLGALDTEFREGLKNSASKTFITTHSAFGYFAERYGLDQEGISGVDPESEPSPARMKELQAVAKKDNVTTVFFEALASDKTAKTLARDTGLRTDVLDPLEGITDKSQGADYFEVMRSNLKNLQKALGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXZ8</accession>
    <name>A0A0F4JXZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945678.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39000">
        <property type="protein sequence ID" value="KJY39000"/>
        <property type="gene ID" value="VR44_02490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6801"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16815" checksum="7C5EE47533EBB0AA" modified="2015-06-24" version="1">MNVSACMSAPAVSVTPTTTVGEAARQMAVHGVGCLAVTEGGALRGIVTDRDIAVRAVAPGLDRDDPVLQVMTTPAVAVGVHDDIHTAYRTFRTSGVRRLPVLDGHRVVGVLTVDDLLMDVFRRVADLLGPVAWSVLEMPPGPADEIGPGARGGGRSPSASRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZC2</accession>
    <name>A0A0F4JZC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_00550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000009">
        <property type="protein sequence ID" value="KJY39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945321.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39757">
        <property type="protein sequence ID" value="KJY39757"/>
        <property type="gene ID" value="VR44_00550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2816"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6457" evidence="5">
        <location>
            <begin position="195"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="30477" checksum="29F27258973AAEFD" modified="2015-06-24" version="1">MSYDAIVLAGGAARRLGGADKPTLPVGGRTLLDRVLAACPDAAATVVVGARRPTARPVDWALETPPGGGPVAALHAGLRGTTAAVVLVLSADLPFLDRDTVRALLTAAAAGPGDGAVLRDPEGRDQPLVAAYRTEPLRREIALLATEHGTLHGLPLRALTAELDLARITAAAPLASFDCDTWEDLATARARIREHGNVLDQWINAAKNELGIDLDVDVKTLLDLARDAAHGVARPAAPLTTFLVGYAAARAEAAGADPAQAVAEASRKAAALALRWAAEAESLDPEPTDPEGNGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZF7</accession>
    <name>A0A0F4JZF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation factor (SUA5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945582.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39214">
        <property type="protein sequence ID" value="KJY39214"/>
        <property type="gene ID" value="VR44_01985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5803"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="29218" checksum="25542229B01E52AF" modified="2015-06-24" version="1">MPSNTPRGPWRGEPVPEALEALSAPGGLVVCATKVGYILMTTDGRGLERKFDAKRRNRNKPGVVLCADLDQLKELAELNEEVLAFYERHWEQDVLLGCILPWRQEALALLPDETTRELATDTRGTSCFVIRFGRPAEQLVERMWAERRLVFASSANPSGVGNRGRVENIGTRIEEEADFIVCADDYVASVQPDKDEDTRHEQGVMVSMVDAEGVLVPVQKGERSVSPAPVLIRRGLDYPVIMENLSEIYPSWDYRHGEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZP5</accession>
    <name>A0A0F4JZP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945539.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39309">
        <property type="protein sequence ID" value="KJY39309"/>
        <property type="gene ID" value="VR44_01750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5752"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7695" checksum="7598B2901A6A4664" modified="2015-06-24" version="1">MWRFIAVRLVGERDSMERTVVRCAEGHVFSTASFPLQHLGAGRIGPGRLLRCPRCARLRHAVPVGGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3E2</accession>
    <name>A0A0F4K3E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945355.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39701">
        <property type="protein sequence ID" value="KJY39701"/>
        <property type="gene ID" value="VR44_00735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2852"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26567" checksum="E3F5EFC300C2FA1C" modified="2015-06-24" version="1">MSRARRRSAPPPADRSVVAGALSLLGELLITVGLILGLFVAYSLWWTNVLADRQASAGGDQVRRQWQQKPGGAAGGPGEPGALDTQDGIGFLHVPSMKNGEVLVKPGTSPEVLNDGVAGYYTDPVKAALPWDDKGNFALAAHRDGHGAKFHNIDKVKRGDAVVFETKDTWYVYKVFAELTQTSKYNTDVINPVPKESGKTAPGRYITLTTCTPVYTSKYRYIVWGELVRTEKVDAKRTPPAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6C1</accession>
    <name>A0A0F4I6C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001767">
        <property type="protein sequence ID" value="KJY16291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16291">
        <property type="protein sequence ID" value="KJY16291"/>
        <property type="gene ID" value="VR44_40520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="16720" checksum="122D05D49F4E2207" modified="2015-06-24" version="1" fragment="single">RAAAGAGGGPEGVLRLEVLGPLAGLRAGPGRIGLERRGESAGFVLTGYDAQGATAPVEPRDLTLDYDRSRWRVTEDGRGGFTVTALVPQASGRLTATVRTTGATAGLALGVGSAAAPLAGFEDAAAWTGPGAAPAEGHPGPGLALEARADAAAAPPRPLPVPELTRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEA0</accession>
    <name>A0A0F4IEA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <ecNumber evidence="2">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_38975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001537">
        <property type="protein sequence ID" value="KJY19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952423.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001537.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19803">
        <property type="protein sequence ID" value="KJY19803"/>
        <property type="gene ID" value="VR44_38975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5513"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="25338" checksum="84213897BB1A50B9" modified="2015-06-24" version="1" fragment="single">TATATSGDGPTVSCEGPDSDQVPLDRTNLAARAAEILAARAGLTPAVHLHIAKNIPVAGGMAGGSADGAAALLACDALWGLGTPREELLEICAELGSDVPFSLVGGAALGTGRGELLTPVEAGGFHWVFAVAHGGLSTPAVFREFDRLAEGTAVPVPEASAELLAALASGDPDALAAVLPRSNGLQPAALSLRPELAETLAAGVSAGALAGLVSGSGPTTAFLVRDAGAAVKVAAELEASGTCRATRVTASPAAGATVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHS0</accession>
    <name>A0A0F4IHS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_38415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001471">
        <property type="protein sequence ID" value="KJY20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952318.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001471.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3731"/>
    <dbReference type="EnsemblBacteria" id="KJY20998">
        <property type="protein sequence ID" value="KJY20998"/>
        <property type="gene ID" value="VR44_38415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5333"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17631" checksum="4AE429D8F3BD1324" modified="2015-06-24" version="1">MSLYDIPLTTLDDEPTSLAAHRGKAILLVNTASQCGLTPQYSGLARLQFKYEEKGFTVIGVPCNQFGGQEPGTAEDIQTFCAAGFGVTFPMLEKSEVNGENRHPLYQELVKTPDADGEAGDIQWNFEKFLISPAGEVVARFRPRTEPESPEVIAAIEAQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJE8</accession>
    <name>A0A0F4IJE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001431">
        <property type="protein sequence ID" value="KJY22150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22150">
        <property type="protein sequence ID" value="KJY22150"/>
        <property type="gene ID" value="VR44_38030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5172"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9677" checksum="9BCE4D27B169CAD9" modified="2015-06-24" version="1" fragment="single">VLHLATRYVDRVVEELLPHYGAECPVAVVAMASRPDELILRGTLADIAEQVKGAGLVRTAVIVVGRTLGAEQFRDSHLYSPERDRHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKL8</accession>
    <name>A0A0F4IKL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001415">
        <property type="protein sequence ID" value="KJY22585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952213.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001415.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22585">
        <property type="protein sequence ID" value="KJY22585"/>
        <property type="gene ID" value="VR44_37855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5130"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470023" evidence="2">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY22585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="30299" checksum="67B4AF7523501204" modified="2015-06-24" version="1" fragment="single">FAGTGGAALALPLMGAAGAHAAAPAAATPAAAPVQAPAAFRTAAPAVTPAAAPSVYTVVSGDCLWTIAAERGLSGGWERLYADNREAVGDDPSLIHPGLRLTLGGQGAAAPKTSGAPAEESSSGTPAPGEDAAGAAPAEDDGAGSAASAGSGGVPLKGSAAPSRGMKQSAPAAQSAPASAAGFVAPVSGGISTQYRTPGAMWSSGYHTGVDFIASTGTTVRAVGAGTVVSAGWGGAYGNQVVIRHADGKYSQYGHLSQLNVSAGQTVTAGQSIGLSGATGNVTGPHLHFEIRTGPSYGSDIDPLAYLRSKGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKU9</accession>
    <name>A0A0F4IKU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001425">
        <property type="protein sequence ID" value="KJY22314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22314">
        <property type="protein sequence ID" value="KJY22314"/>
        <property type="gene ID" value="VR44_37960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5156"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7795" checksum="030DF3FC3D7CCF8D" modified="2015-06-24" version="1" fragment="single">RGVGQALVEAACLAARAQGARRITLRVLGHNLPARRLYERCGFQVEGVLPEEFLLDGAYVDDVLMGLRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPX7</accession>
    <name>A0A0F4IPX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001297">
        <property type="protein sequence ID" value="KJY24080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951935.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001297.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24080">
        <property type="protein sequence ID" value="KJY24080"/>
        <property type="gene ID" value="VR44_36365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4525"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6674" checksum="ABA63F51D5FE20E1" modified="2015-06-24" version="1">MKTTSMIRNIANPRRTTLAHLKDAEELQAAPATPEHRVELPTQTANPRRTVLMNAPAAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQA5</accession>
    <name>A0A0F4IQA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001270">
        <property type="protein sequence ID" value="KJY24205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951877.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001270.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000049_gene3459"/>
    <dbReference type="EnsemblBacteria" id="KJY24205">
        <property type="protein sequence ID" value="KJY24205"/>
        <property type="gene ID" value="VR44_36065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4371"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="277"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="399" mass="40891" checksum="CAB9DA917824FDC8" modified="2015-06-24" version="1">MSIRTVRDVYVVDAVRTPIGKFGGALAGVRPDDLAAHVVRALVDRTPDLDPARIDDVVFGDANGAGEDNRDVARMAVLLAGLPVTVPGATVNRLCGSGLEAVIQAARAIALGDASVAIAGGVESMTRAPWVVQKPERAHPAGHQQMWSTTLGWRMTNPRMPAEWTGSLGEGAELIAEKHGITREAQDAFALDSHRKAAAAWNAGLYDGEVVPYPGVDLQRDECIRESSTLEALARLKPAFRTDGTGTVTAGNASPLNDGAAALLLTDEAGLAATGREPLARISASAVTGIEPQFFGLGPVDAVQRALAKAGRDLSGLAAFELNEAFAAQALGCLAAWPELDPAVVNPRGGAIAIGHPLGASGARLAGSVAHQLAAAGSGTGMAALCIGVGQGIALVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQW5</accession>
    <name>A0A0F4IQW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001303">
        <property type="protein sequence ID" value="KJY24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951950.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001303.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3608"/>
    <dbReference type="EnsemblBacteria" id="KJY24054">
        <property type="protein sequence ID" value="KJY24054"/>
        <property type="gene ID" value="VR44_36450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4542"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="28343" checksum="D38C114F48D689C5" modified="2015-06-24" version="1">MTRTFDHLVAEAESVSVDGWDFSWLDGRATEQRPSWGYQGMLAERLARVRSALDIQTGGGEVLAGAGPLPPLTAATESWPPNIEKATRLLHPLGAVVVADTDEPPLPFGSDAFELVASRHPVTIWWEEIARVLTPGGTYFSQQVGPASVFELVEYFLGPQPEEVRRARHPDDAVADARKAGLEVVDLRSERLRTEFHDIGAVIYFLRKVIWMVPGFTVGHYRDRLRELHERIEREGPFVAHTARFLIEARKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR09</accession>
    <name>A0A0F4IR09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001291">
        <property type="protein sequence ID" value="KJY24109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951921.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001291.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24109">
        <property type="protein sequence ID" value="KJY24109"/>
        <property type="gene ID" value="VR44_36295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4508"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="220"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="595" mass="66084" checksum="6089CC2CA6703C2D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRD5</accession>
    <name>A0A0F4IRD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_36520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001307">
        <property type="protein sequence ID" value="KJY24033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951963.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001307.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24033">
        <property type="protein sequence ID" value="KJY24033"/>
        <property type="gene ID" value="VR44_36520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4609"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="49"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="523" mass="55354" checksum="A17A06A8C199AEC4" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRE8</accession>
    <name>A0A0F4IRE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001197">
        <property type="protein sequence ID" value="KJY24595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24595">
        <property type="protein sequence ID" value="KJY24595"/>
        <property type="gene ID" value="VR44_34910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14311" checksum="215FBD71F86446D5" modified="2015-06-24" version="1" fragment="single">MAHTGPQSLDRALALVDAVAAAPGPVSAKALARAAGCSLSTAYHLLGPLTERGYLVRTARGYALGPELPRLHRSFLHQLAPAPGMGDLLARLRRATGGETYHTAYRGGVITVVDTTAPVTDTANPFAPGRETRADATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS19</accession>
    <name>A0A0F4IS19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001228">
        <property type="protein sequence ID" value="KJY24439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951749.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001228.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24439">
        <property type="protein sequence ID" value="KJY24439"/>
        <property type="gene ID" value="VR44_35380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4189"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="50"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="672" mass="71972" checksum="A9A7980FBD5BBD14" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS30</accession>
    <name>A0A0F4IS30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_35310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001226">
        <property type="protein sequence ID" value="KJY24449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24449">
        <property type="protein sequence ID" value="KJY24449"/>
        <property type="gene ID" value="VR44_35310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4174"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="27142" checksum="A8EDEAEE8926B230" modified="2015-06-24" version="1" fragment="single">MRYAILGPAQAVRDDGTPVAVGGARLRALLTALALRPGRTVPVALLVAEVWEADPPADAVAALQALVARLRRALGHGAVRSEEGGYRLEAERGDVDLYRFEGLVRSAAAAADPARAAALYDEALALWRGPALASLPDPAAESARWEAVRMDARRGRLGAALALGEAAQALPELTELCARRPLDESLQALRIRALRAAGRPAEALAAYETVRRDLSTRLGTDPGPALRALHTELLSGTPAPEPPPATAAPAWPAPATPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS47</accession>
    <name>A0A0F4IS47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic synthesis protein MbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001163">
        <property type="protein sequence ID" value="KJY24827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030756641.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001163.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24827">
        <property type="protein sequence ID" value="KJY24827"/>
        <property type="gene ID" value="VR44_34200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3811"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7583" checksum="7DD8150F993757A9" modified="2015-06-24" version="1">MNDASPQQYLVVANDEEQYSLWEAGRPVPLGWHDQDVRGTKEECLAHIERVWTDMRPLSLRVSMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISN1</accession>
    <name>A0A0F4ISN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001133">
        <property type="protein sequence ID" value="KJY25015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25015">
        <property type="protein sequence ID" value="KJY25015"/>
        <property type="gene ID" value="VR44_33690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3647"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="106" mass="11532" checksum="AA2C75855E0320F1" modified="2015-06-24" version="1" fragment="single">VIVWDLGTYRNATSDREGNEIPLTEGLERGHASFLLDGRKLHGGYSLTRIRDADDGGKEAWLLVKHADGHASTTGTPDPRRARSVRTGRTLHQVAAGVRPGRGDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISU2</accession>
    <name>A0A0F4ISU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001212">
        <property type="protein sequence ID" value="KJY24528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24528">
        <property type="protein sequence ID" value="KJY24528"/>
        <property type="gene ID" value="VR44_35110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4099"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23708" checksum="7EE93BB33349DCB9" modified="2015-06-24" version="1">MGRPGQAHDLMDEEFERAVTWGSPVAIGRAQRGRGAITGGERGLALLRESAATLERTAHVLEQARTSLLLGRRLLTAGREAEAEHRLTRARDQGLRCGAPWIADRAGRALHTIAGSQGADAVAALTRTERRVAALAARGTSNRAIAEGLEVSARAVEKHLTRAYRKLRIDGRAELAPMAQLLAQECPGTPARGGGGEGGPAGPGTEPNRSLPVPPVTVPSGPRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISW4</accession>
    <name>A0A0F4ISW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001173">
        <property type="protein sequence ID" value="KJY24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007263382.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene46"/>
    <dbReference type="EnsemblBacteria" id="KJY24749">
        <property type="protein sequence ID" value="KJY24749"/>
        <property type="gene ID" value="VR44_34390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3856"/>
    <dbReference type="eggNOG" id="ENOG5032ZDA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7640" checksum="72F09200B573D569" modified="2015-06-24" version="1">MAETLKKGSRVTGAARDKLAADLKKKYDSGASIRALAEETGRSYGFVHRMLSESGVTLRGRGGATRGKKAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISZ9</accession>
    <name>A0A0F4ISZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001198">
        <property type="protein sequence ID" value="KJY24588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24588">
        <property type="protein sequence ID" value="KJY24588"/>
        <property type="gene ID" value="VR44_34915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4059"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12580" checksum="1DF105600541295E" modified="2015-06-24" version="1" fragment="single">ETRAHATAHGKALLARLTPRARRRYLDEHGMARLTPATITSAEALEAELLRVRAAGIAVSVGEADPAWTCLGVALPPAGEERDTVHALSVSVPTQEFRRRPEAIRAALAEAASLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT39</accession>
    <name>A0A0F4IT39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_TE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001342">
        <property type="protein sequence ID" value="KJY23871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23871">
        <property type="protein sequence ID" value="KJY23871"/>
        <property type="gene ID" value="VR44_37010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4788"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16671" checksum="3F42B9D5D3300D6F" modified="2015-06-24" version="1" fragment="single">DPVVLVGYSSGGWVAHAVACRLEQLGRPVEGIVMLDSFSRARGMGDRFQAAVVREQSDRFEFISAPGTQLTAMGGYLALFEDWHAPEAAAPTLVVRAADGMADGAAPSADRTDDRPPAPEHARTITEVPGNHYTLMERHAESTATAVDEWILKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITH9</accession>
    <name>A0A0F4ITH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_33905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001145">
        <property type="protein sequence ID" value="KJY24939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24939">
        <property type="protein sequence ID" value="KJY24939"/>
        <property type="gene ID" value="VR44_33905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3707"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY24939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="29867" checksum="4429CCB8EBE52814" modified="2015-06-24" version="1">MPGYVAQLWARRHFVIAYATARMQATYSTAKLGQVWHLMTPLLNAAVYYFIFGMVMHASHGVPDYLPFLITGVFVWDFIGSSINTGTRAVHSNLGLVRALHFPRASLPLSSVVQLFQQLLVTMGALVILLLAFGQMPSPSWLLAAPALFLMAVFCSGCAMVMARIGSKNPDVSQLMPFVLRTWMYSSGVMWSIDAMLRSDHLPHWVTMMLKLNPAAVYIDLMRFALIDSFKASQLPDHVWLIAIGWALLAGVGGFVYFWKAEEEYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITK1</accession>
    <name>A0A0F4ITK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001142">
        <property type="protein sequence ID" value="KJY24959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001142.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24959">
        <property type="protein sequence ID" value="KJY24959"/>
        <property type="gene ID" value="VR44_33835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3692"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="18065" checksum="15C61B35B48022E0" modified="2015-06-24" version="1">MIRTALLEDLDAIAALHTRARATYYRGRIPEQAYAGEAELARSREGWSRAVRRTEAEGRVFCAERDGEITGVAAYLTADGETTLTQLHVDPVHWRRGTGAALHAACVAAWRRAGVERVRLEVYEHNLRAQAFYASHGWRPDPSAVPSGSHRTLWLEVGEASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITQ7</accession>
    <name>A0A0F4ITQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001133">
        <property type="protein sequence ID" value="KJY25014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951438.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001133.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25014">
        <property type="protein sequence ID" value="KJY25014"/>
        <property type="gene ID" value="VR44_33685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3646"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="33371" checksum="87D0315AA6A44B95" modified="2015-06-24" version="1">MTRHVVEIGRPDKVLFPGDGITKADLAGYYRTVARRMLPQLRGRPLMLERHPDGTDGPAFMQKDVPDHFPDWIHRVELPKEDGTVTYVICDDTATLRYLAGQACITPHRFLSRADRPGHPDRLVFDLDPADEDFAPVREAALGLHQLLDELELPSLLMATGSRGLHVVVALDRRAPFDEVRAFARGVAGVLAARHPGRFTTEARKKARRGRLYLDVQRNAYAQTAVAPYAVRARPGAPVAAPLAWSELDDPRLTSRRWTLATVDGLLEDDPWQDAPRPRSLRRPGSLLGALVRDEGSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU73</accession>
    <name>A0A0F4IU73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001264">
        <property type="protein sequence ID" value="KJY24236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951855.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001264.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24236">
        <property type="protein sequence ID" value="KJY24236"/>
        <property type="gene ID" value="VR44_35945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4347"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470260" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="39"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="211"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="454" mass="47485" checksum="159F27EDEC287AD0" modified="2015-06-24" version="1">MSQQGHRRPRLSKKLLAVVSALVLGGGGVAIVAGNANAGQDASRTGQVTATIDCPDVGDKLTAVPDGARTEVDENLAQLDVQVADAYRQLAGGQVKGKAQQDALLGRLRDQRGTTISRVSDAIGRSGARPEGLGTLSGCTMKEASAQEDAAADGARSIGQKGGPAKSDFVDITKVRPNVKAPAPSAAASKGSFTSECGRNENGHFNPDNVIVAPGVSNGAHHMHDYVGNKTTSAFSTDASLAASGTTCGNGDQSTYYWPVLRLRDGRAERDAKAPGGGQDANVGTILRPKQATITFKGSPAGQVKAMPRFLRIITGDAKAFSNGTANANASWSCTGFEDRQLKDKYPVCPKGSDVVRTFTFQSCWDGRNTDSANHRTHVAFPDASGRCKKGFTAIPQLVERVTYGVAPGARFAVDSFPEQLHKPVTDHGDFINVMSDGLMARAVGCINGGRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVE2</accession>
    <name>A0A0F4IVE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001002">
        <property type="protein sequence ID" value="KJY25972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950964.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25972">
        <property type="protein sequence ID" value="KJY25972"/>
        <property type="gene ID" value="VR44_31120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2710"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="331" mass="36412" checksum="C139F3553D9E7E38" modified="2015-06-24" version="1">MTRTTPARPVEVEAVFPELAAYRGRTTRLHPRPGRPGRHDSHVGGPLLWPGDEPWPVCREPHMPETEGYAPDEIRAARAVGAWPRSQPWPGAGSPWTGGPVPFVALAQFFGRDVPGLAAGPGGADLVQLLRCPLTHGPYLERRYLLRWRQASQTESADRFLTAAPEVPLLPREHELPEPCVLHPEQVETYPWAEDDTLPAALIARIDAWEDAQTAEAGRDAPSYQGDLSIPPGWRVGGFPSWASTGPMDITCTSCADPMRLLLTAEGYEMDSGSHSWMPLEDRDPSLQGMASIQGGQSVTQPTRLRFGRDRDLHVFTCPTDPGHPPRWVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVZ5</accession>
    <name>A0A0F4IVZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001022">
        <property type="protein sequence ID" value="KJY25809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951048.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25809">
        <property type="protein sequence ID" value="KJY25809"/>
        <property type="gene ID" value="VR44_31585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2814"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17967" checksum="5EF148CD422A7C5D" modified="2015-06-24" version="1">MDLHAYVRRARSGPCFVCAFLAGDPDYRHETVFEDEDHIAFLDRWPTVAGKVLVAPKAHVEHVVRDLDDEAYGQLMLFVREVALAVESVCGSERTYLYSLGSQQGNAHLHWHIAALPPGVPYEEQQFHALMTENGVLTPPPGQSAALAAHLGEAVRARGRLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWN1</accession>
    <name>A0A0F4IWN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000992">
        <property type="protein sequence ID" value="KJY26039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26039">
        <property type="protein sequence ID" value="KJY26039"/>
        <property type="gene ID" value="VR44_30965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2637"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="24937" checksum="51B8498F9F993A69" modified="2015-06-24" version="1">MPELCAVLPQFQYAATAITAVAVGPEQREQAATALRADARNLFVAKALHELTGETDRLFAAAEAALATGARGGAEGARALADLGPAAARLTPALRTVLHRTTDRDTTPELDTDLGLALALWRITGDAAEAVPVLASVFDRSEGQQWFALLITAALRRHGVGAQPTVDTLRAARNAHALWVSLAGTGPPGRWRPGGPAARGARRPRGDPPARSRAHPVAEPDVGIGDPCGGVVRRGGCGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXR8</accession>
    <name>A0A0F4IXR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000961">
        <property type="protein sequence ID" value="KJY26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950849.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000961.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26263">
        <property type="protein sequence ID" value="KJY26263"/>
        <property type="gene ID" value="VR44_30490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2513"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="31209" checksum="E4286F9ED9274D70" modified="2015-06-24" version="1">MTAIPLPPVPEPFRLPFHYGALHQLGVDWLVDPGPVRDLLAKHHPDLSTAEFDDGRALVSLNYQLYFAQYPFGGGITQEIEYNVIAYPTADAGRLPALTYAQYAQGWDQTKLLGIARIHVVCDNPFAIRAGRELYAEPKFPGWFEVALPSLNGPAGETWTVRCNAAGIGPDGDTLTRGGTPLLDLTAALDGLTPVPANLAPVTGYGTTEDGRLLAGPMNVYQPYRWYDLGAPEHAERTRVTVHAPEGDLGRDVRSLLGDTPAAGAWTFQSAPVAAHNRAYYLPAGRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYV2</accession>
    <name>A0A0F4IYV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000914">
        <property type="protein sequence ID" value="KJY26648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950683.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000914.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26648">
        <property type="protein sequence ID" value="KJY26648"/>
        <property type="gene ID" value="VR44_29570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2291"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="26154" checksum="FA331931ACC1D772" modified="2015-06-24" version="1">MARRRETARTRQPRHERRGEARLPAVVATLTAIGLYLVLPQQLLITPRFALPALEVLLLLPLIAINPRRLTRQTKTFRVLSLTLVLTIAAGNLAALGLLIDQLVHAKVADGRSLLIAALQVWLTNIIVFGLAYWELDRGGPVARTQQLRDELPLADFRFSQDENDDAVGEVADGASKNSDWVPTLMDYLYVSVTNSTAFSPTDTMPLTTRAKLLMAIQSVAALATSLLVIARAVSILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZF3</accession>
    <name>A0A0F4IZF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000839">
        <property type="protein sequence ID" value="KJY27405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27405">
        <property type="protein sequence ID" value="KJY27405"/>
        <property type="gene ID" value="VR44_27655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1767"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="53"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="32089" checksum="BED39D895FDE31DD" modified="2015-06-24" version="1">MDRLDGLAPSRARERLGDALFRHVAGPSGAENRARIHDTPGPRWFAPEEPICRVHGDASMFVGGLSALLLQSLHPRAMAAVEAHSGYRGDPWGRLQRTSTFLAFTTYGTAEDAQRAVDGVRAVHARIRGRSPDGEPYRADDPHLLEWVHVAEVDSFLRAHQRYGARRLDAAECDAYVASAARVGRALGVPRPPRTARELAERIEAFRPELRGTREARAAARFILLRPPLPWPARPPYAMLAAAAVALLPPWARHPLGLPLLPRTERWCAAPAGAAVTSTIRWAMHRPPAADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0M7</accession>
    <name>A0A0F4J0M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000938">
        <property type="protein sequence ID" value="KJY26456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26456">
        <property type="protein sequence ID" value="KJY26456"/>
        <property type="gene ID" value="VR44_30035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2390"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470458" evidence="1">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="23799" checksum="FFFCC1A51BB5E4AE" modified="2015-06-24" version="1">MSRTLLTAAAAAALVAASAPAGAAAPVSGGRAQITVPPDKIVIELATVNGSGCREGTAQVAVAPDNTAFTVTYSDYLAQIGPGAPPTAFRKNCQLNLRVHVPSGFTYAIVQADYRGFAFLQPGASGQERASYYFQGMPQTAQRTHSFTGPLNDNWQTSDKTEYADLVWSPCGEKRNFNINTELRVNAGTSNPQTATSFMAMDSTDAGVSTLYHLAWQTCPAPKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1E8</accession>
    <name>A0A0F4J1E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000765">
        <property type="protein sequence ID" value="KJY28092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28092">
        <property type="protein sequence ID" value="KJY28092"/>
        <property type="gene ID" value="VR44_26130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="17973" checksum="40FE0F2E0B532749" modified="2015-06-24" version="1" fragment="single">MSKGANLPLAASSVRAVLGWSAGPGVPDVDASALLLAGGRVRSDGDFVFYNQPRHASGAVRHAGKRPGADALDVDLAALEPDIERVLLCASADGGTFGHVPGLHLRLLDAVSGAEVAHFPMEAGPETALVSGELYRRAGVWKFRAVGQGYASGLAGLATDYGITVDDAPPAPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1F4</accession>
    <name>A0A0F4J1F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000819">
        <property type="protein sequence ID" value="KJY27563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27563">
        <property type="protein sequence ID" value="KJY27563"/>
        <property type="gene ID" value="VR44_27240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6653" checksum="F644AE59AF35C6F8" modified="2015-06-24" version="1" fragment="single">MDERAQDDPERRRAWARELVAGLTAAEDADRALAAVLDPEPDLQAENDARRARAVHAAAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1V5</accession>
    <name>A0A0F4J1V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000891">
        <property type="protein sequence ID" value="KJY26896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26896">
        <property type="protein sequence ID" value="KJY26896"/>
        <property type="gene ID" value="VR44_28945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2088"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22553" checksum="091470AB61377A81" modified="2015-06-24" version="1" fragment="single">MLELILPTAVACAESFADVPESTLLPEELEALGTARHEGRRREFTTVRHCARRALADIGVPPVPVLPGERGAPVWPHGVVGSMTHSAGYRAAAVALAGHVRAVGIDAEPHAALPGRTLGAVTRPEEREALAALAADFPQVHWDRLLFCAKEAVYKAWFPMTRRRLGFQDASVTFDPAGGTFRAAMVEATGEQPPAPLVYEGRWAAAKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2K6</accession>
    <name>A0A0F4J2K6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000721">
        <property type="protein sequence ID" value="KJY28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28537">
        <property type="protein sequence ID" value="KJY28537"/>
        <property type="gene ID" value="VR44_25110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="10177" checksum="4FA6C0CE9F4246A2" modified="2015-06-24" version="1" fragment="single">PWPLDWQRHYRVPADLVDADGHLPDITPGVLLDGDDIGWWLRQQKQPATWARLLPEQQERLTAIGVQPDQAPAPAPAGQAQQAFQRGLAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2U1</accession>
    <name>A0A0F4J2U1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_26225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000769">
        <property type="protein sequence ID" value="KJY28033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950071.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000769.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000047_gene2136"/>
    <dbReference type="EnsemblBacteria" id="KJY28033">
        <property type="protein sequence ID" value="KJY28033"/>
        <property type="gene ID" value="VR44_26225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1405"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="206"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY28033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="48258" checksum="0536FA9B3FE991EB" modified="2015-06-24" version="1">MTDPKQRLDVLRADIERRNPAQPEFHQAVREVLDTLAPVFAARPEYAEAGLVERLVEPERQIIFRVPWTDDRGRVHVNRGYRVEFNSALGPYKGGLRFHPSVDIGVVKFLGFEQIFKNALTGLGIGGGKGGSDFDPHGRSDAEVMRFCQSFMTELYRHIGEHTDVPAGDIGVGGREIGYLFGQYRRITNRWEAGVLTGKGQGWGGSEIRPEATGYGSVLFAGEMLAVKGVSLDGLTAVVSGSGNVALYTVEKLQQLGANPLTCSDSQGYVVDDKGIDLALLRQIKEVERGRVSEYAARRGPSARFVPGGRVWEVPADVAFPSATQNELGADDARALIANGVKAVSEGANMPTTPEAVHLFQAAGVAFGPGKAANAGGVAVSALEMSQNAGRSAWSRDRVEDELAGIMREIHRVAYETAARYDAPGDYVTGANIAGFERVADAMLAQGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J367</accession>
    <name>A0A0F4J367_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000845">
        <property type="protein sequence ID" value="KJY27351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950363.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000845.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27351">
        <property type="protein sequence ID" value="KJY27351"/>
        <property type="gene ID" value="VR44_27810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1800"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13487" checksum="6D11549B98EA91A2" modified="2015-06-24" version="1">MPDEPQRRSPRRTRLYALTDGRTSAAPQTVLTMDTTIVAAVPADDEDPGLATEWRAVLALCAPPRGMAVAEIAARTHMRLTPMTLLLGELADRGLIDHRPPLEGAETTNVHLLMKIRDNLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3C5</accession>
    <name>A0A0F4J3C5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000697">
        <property type="protein sequence ID" value="KJY28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000697.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28857">
        <property type="protein sequence ID" value="KJY28857"/>
        <property type="gene ID" value="VR44_24330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.848"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7052" checksum="2BD506C161066AD3" modified="2015-06-24" version="1">MHADVNELSWRKSSYSNSDGASCVEVSDDVPGAVPVRDSKQAGGGPVVVFAGAAWASFIQDVKRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3P7</accession>
    <name>A0A0F4J3P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000740">
        <property type="protein sequence ID" value="KJY28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949951.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000740.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28338">
        <property type="protein sequence ID" value="KJY28338"/>
        <property type="gene ID" value="VR44_25580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1215"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="24772" checksum="55111985F7508E2F" modified="2015-06-24" version="1">MTDPDARELLHAAARNNAEWCGAVSRSGHFRRTVWCSPRRTPPLYPDAVTLTPAASAADVLAGVDTTAPGCSVKDSFASLDLAPAGFEVLFDAQWIHRPAGAAAPSGGRLEWDEVEGPGELAAWEAAWSDGERGGTGLFHPGLVRQGIVFLAGRDGERIAAGAVLSTGGGAVGVSNVFGRTRADTDEAWAAALDAAARDRPDLPVVGYEHGEGLEAAVRAGFTPIGPLRVWLQRHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Y3</accession>
    <name>A0A0F4J3Y3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">VR44_27130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000810">
        <property type="protein sequence ID" value="KJY27646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950242.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000810.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6912"/>
    <dbReference type="EnsemblBacteria" id="KJY27646">
        <property type="protein sequence ID" value="KJY27646"/>
        <property type="gene ID" value="VR44_27130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1614"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19906" checksum="32E1568B88ACDAAD" modified="2015-06-24" version="1">MRQRPIPGTTGLVRTMSLLGDPVLHSACAEVTAFGPELDRLIEDMFATMYAAQGVGLAANQIGVGQRVFVYDCPDDEDVRHVGHVVNPRLVEADGDEFLGPEGCLSLPGLEAGTARFDRAVVEGVTSDGSPVRIEGTGFFARCLQHECDHLDGTVYADRVTGLRARLLRRAIRKTSWGRAAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Z2</accession>
    <name>A0A0F4J3Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000679">
        <property type="protein sequence ID" value="KJY29072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29072">
        <property type="protein sequence ID" value="KJY29072"/>
        <property type="gene ID" value="VR44_23820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="11619" checksum="7A74DFF07AC50DE4" modified="2015-06-24" version="1" fragment="single">MPGMTPQIEALMRTADPDAVWAVGSAYTVHAARPGPPGDWDTPLAAPSLTPALALWPVLGTLVAQGELALHTPLAAYGQPPAAGAPAGTTTHQLLTRADGPAAAAALTRLAEQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4S2</accession>
    <name>A0A0F4J4S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000706">
        <property type="protein sequence ID" value="KJY28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949783.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000706.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28733">
        <property type="protein sequence ID" value="KJY28733"/>
        <property type="gene ID" value="VR44_24705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.938"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="27347" checksum="49BAD0B65998339C" modified="2015-06-24" version="1">MSVITAAYARTVRKESGGPGLLLAHGGGGGVESNFGVILDALAAEYSVVGVDYPGAGETPVAEGPLRLDELADQLVAAADAEGLETFAVLGYSLGGNVALRIAARYPERVTALVLTATFVRAGNRLKFVGDLWSGLAARGENELLARLMVPLALNPAVLEGLSAEEAEEVVRATAASVTAGTVGQVDLIKGADLRAEAAGVSVPALVIATTEDRLVPLELQKELAEAVPGARYAELPTGHLPFAERPAEWAALITEFLSEQRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5E5</accession>
    <name>A0A0F4J5E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949386.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000042_gene5981"/>
    <dbReference type="EnsemblBacteria" id="KJY29577">
        <property type="protein sequence ID" value="KJY29577"/>
        <property type="gene ID" value="VR44_22515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.393"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="24763" checksum="CA01BD59FB3C44F3" modified="2015-06-24" version="1">MSDITVVHVMRHGEVHNPDGVLYGRRAGYHLSELGRQMADRVAEHLQDRDVTYVVASPLERAQETAAPIAKTHGLELATDGRLIEAGNVFEGKTFGVGDGALRKPGNWKHLTNPFKPSWGEPYVEQVVRMMSAIEAARDAARGHEAVAVSHQLPIWIVRSFAEKRRLWHDPRRRQCTLASLTSFTYQDDKLVSVGYSEPARDLVPAHLLAGAKPVKGKSKAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5F1</accession>
    <name>A0A0F4J5F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_22545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949391.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29582">
        <property type="protein sequence ID" value="KJY29582"/>
        <property type="gene ID" value="VR44_22545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.399"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11630" checksum="B7E321913CAA379E" modified="2015-06-24" version="1">MLRYLPFLLILALTIYAFIDCLNTPEEEVKSLPKGVWVLIILLFSIVGPVVWLLAGKKRTAAGGAGGFGGGGRARRTQWVAPDDNPEFLRSLRKDEDDEKDKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5T9</accession>
    <name>A0A0F4J5T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000634">
        <property type="protein sequence ID" value="KJY29555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949406.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000634.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29555">
        <property type="protein sequence ID" value="KJY29555"/>
        <property type="gene ID" value="VR44_22630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.419"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15860" checksum="C7C2DA58E9AA190C" modified="2015-06-24" version="1">MTKSPEPQSRAVAERQLCGLVDGLAQRIAEHVRERAATLGLTASQATALREMSGSMTMRELAERMNCEPSNATFVVDRLEKQGLVERHPHPTDRRAKLLVLTGEGTALRTRLLDLLHVDSPVACLAPEEQRVLRDLLERAVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J624</accession>
    <name>A0A0F4J624_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000663">
        <property type="protein sequence ID" value="KJY29218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949566.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000663.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29218">
        <property type="protein sequence ID" value="KJY29218"/>
        <property type="gene ID" value="VR44_23510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.644"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="21752" checksum="36531D51E1B501EB" modified="2015-06-24" version="1">MDISGVRIRGLRAALFSALVVLLSAGSHVLLSRVPLPPALLGGAFAGVFAIAYALAGRERGFGPIAGLLVPLELTADTVFTAGQRVCYGPAGGPVSGPLHALGLDGLCGGTPVGGPLAEVAGPAGDPAALLAAPGPWTPWMLLGAHVGVGLLAAAWLRHGERALVRPLRLAAASVAAVPGRAGRALRPARAGAVALTRFPAHSVGRRGPPVRTATPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J681</accession>
    <name>A0A0F4J681_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000658">
        <property type="protein sequence ID" value="KJY29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949538.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000658.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29278">
        <property type="protein sequence ID" value="KJY29278"/>
        <property type="gene ID" value="VR44_23370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.614"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="92"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26936" checksum="1118CC0F68A1C09F" modified="2015-06-24" version="1">MDDGKPADKPTASSSGSPSPSGSGQPPSKTPEDDSPTVPGEPNLLRDRNGKMGIALGPGASLGELNQRTEVRFKGAADSYAQGAEAAVDVSKSFTVSTRAYNVTEGGSRMAVSQGDGDSYSFELGFEVVGGKKAWVFRVQTGDKGQAATAQQVVADNVDTTKKWALLTGTYDAEKKTIALWVDDKQAGQAQVSGIWAGPGPLQLGRARHHGIWSASWDGALDHIRIFDQALGQEQITGLKNNKLGKTRPTHSWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6F6</accession>
    <name>A0A0F4J6F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000650">
        <property type="protein sequence ID" value="KJY29363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7540"/>
    <dbReference type="EnsemblBacteria" id="KJY29363">
        <property type="protein sequence ID" value="KJY29363"/>
        <property type="gene ID" value="VR44_23110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.561"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="496"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="588"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="710" mass="75060" checksum="48F7255F7C23C91B" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6U7</accession>
    <name>A0A0F4J6U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000634">
        <property type="protein sequence ID" value="KJY29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949405.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000634.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29554">
        <property type="protein sequence ID" value="KJY29554"/>
        <property type="gene ID" value="VR44_22625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.418"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="64"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="29708" checksum="0A46CFC2A218C4B5" modified="2015-06-24" version="1">MPEHDTRLSRPSGIRTLHLGETKVTYLPDGAARFRPSALLPDTTAATWTAHPEYLDETGHLTGSLGALLVEHGGRALLIDTGIGPHAFETPDGPLHSAHGGALPDSLAALGRRPEDIEAVAFTHLHPDHTGWACEPLLGHAEFLLSGPEWEARDAVQPHVTAALSKNVRTITDGEEVFPGVRVRIHPGHTAGHAEYVVTGGGRRLIAFGDAMHSPLQAAHPSWSAGFDHDLTATAGHRHRLVAELSQPDTIGFGVHFADVVFGHVRDTAAGPAWHPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7H9</accession>
    <name>A0A0F4J7H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949322.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5168"/>
    <dbReference type="EnsemblBacteria" id="KJY29744">
        <property type="protein sequence ID" value="KJY29744"/>
        <property type="gene ID" value="VR44_22175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.319"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="26086" checksum="5E1FDBE1281C4560" modified="2015-06-24" version="1">MSDTSRPRASLRTAVVWEVLKEALDRRVKATGRDVLDVLDTGGGTGKFAVPVARLGHRVTVVDPSPNALFGLERRVAEEGVADLVRGVQGDAQGLLDVVERDAYDVVLCHGVLEYVDDPAEGVANAVAALRPGGVLSLLGAGLGGAVLARALAGHFTEARTALTDPAGRWGAGDPVPRRFTAEQLAELVGAAGLEVGSVHGVRVFADLVPGVLVDTEPGAVEALLRLEEAAAELPAFHAVATQLHVLGEKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8V1</accession>
    <name>A0A0F4J8V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000584">
        <property type="protein sequence ID" value="KJY30173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949109.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000584.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30173">
        <property type="protein sequence ID" value="KJY30173"/>
        <property type="gene ID" value="VR44_21060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8891"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27983" checksum="048A8D897260EBD6" modified="2015-06-24" version="1">MSRTTRIIPIPVLGRNGINAYLLLGRRPVVVDAGTPGSGRKIHDAIAAHGVDPADVSLIVLTHGHIDHFGSAAELSRLTGAPVAGHVADLGPYRSGRVREPYLPTGPMGRLMARNGKLHARAEPVEPEVLLRGETDLSETDLSDYGIEARVMPTPGHTAGSVSVLTGQGDLVAGDLIANSFMGLIPGRPASPPFHDDPVGNLASLKRMLDLDPTRLHVGHGSPLEPARVRRWAAREERRLARRRAAGRLRTRGPEPDPQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9B1</accession>
    <name>A0A0F4J9B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000635">
        <property type="protein sequence ID" value="KJY29546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949418.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000635.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29546">
        <property type="protein sequence ID" value="KJY29546"/>
        <property type="gene ID" value="VR44_22695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.471"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="21947" checksum="4522A3D4919EBFDB" modified="2015-06-24" version="1">MTERERMTGTVTARPSAAGIVRVWGASLVRRPLRRGPGRGLRHSASTRQLVLVMAVTEAVTAFVFSSLLPPAVRPVHAACELFLILAGLGLVAALLRHPHTVDDEHVALRTGFLGELVLPRSAVRSAAPVVRTVPGRGPRVVPDEPGAVACSVEASVNVVLRLDPPVRLDLGRSGRLDVTTVYTSADFPSELAAAIRGPVRGRSAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z8</accession>
    <name>A0A0F4J9Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000551">
        <property type="protein sequence ID" value="KJY30629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948916.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000551.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30629">
        <property type="protein sequence ID" value="KJY30629"/>
        <property type="gene ID" value="VR44_19995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8620"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="20838" checksum="D1CE48EB6E39BBEF" modified="2015-06-24" version="1">MIETLGSLTATPWIYVLVAVSVLLDVFLPVLPSGVLVITAAAAAAGGPPARVPDVAVLLTVAATASVLGDLTAYRLARRSGPRLDRAIARSRRLTRAHERLGTALARGGGLLVVLARFAPAGRSVVSLGAGKTQRKVGEFLPWSVLAGISWAGYSVSLGYFGTQWLGTAWLGTAVSLIALFTAGSLAAFLLRRPSPTPPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAG7</accession>
    <name>A0A0F4JAG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948819.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30799">
        <property type="protein sequence ID" value="KJY30799"/>
        <property type="gene ID" value="VR44_19445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8498"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="28569" checksum="532093CB29A5D506" modified="2015-06-24" version="1">MALRAHGAHAGRVRTEANGTATGPVARFLENPVVGMAPWIVFSLLAGPGRFEIAVGIALGLTVALVVAGRVVHRGSSWKLLELADVVFFAALAVIGALADDGTLRWLETYAGEVASLTLTAIAFGSMAFRMPFTLQYARERTDPSVWHSPAFLRTNYMITGVWGLAFLVSALAGGFGDLVLHEPDNIWTAWIVPVLAIVAALRFTAWYPDVVRARARGEPGPGPASLLLPLAGLLVPVGIAVLVFDGGVWWLGVALIVAGVLLTKALQAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAY1</accession>
    <name>A0A0F4JAY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949120.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000588.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30131">
        <property type="protein sequence ID" value="KJY30131"/>
        <property type="gene ID" value="VR44_21125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8948"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="20141" checksum="F223A35062C68E7B" modified="2015-06-24" version="1">MFEGNLVRLRALRAEDAEHHLRWRNDPEVVRLAAAGDPLFGPVTAEAVRIAFEGKLRLVPREAAVFTVEDLASGAVIGMADYRDLDPYAGVATLGITIGEREFWGRGHGSEAVRLMVDHLFGAYGLHRLELDTWSGNERAVRAFSKLGFREEGRLRAAVLVAGKRYDRVLFGMLREEWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB32</accession>
    <name>A0A0F4JB32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">VR44_19215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948774.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5441"/>
    <dbReference type="EnsemblBacteria" id="KJY30943">
        <property type="protein sequence ID" value="KJY30943"/>
        <property type="gene ID" value="VR44_19215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8449"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="36794" checksum="0FD31B8CF6984B1C" modified="2015-06-24" version="1">MASDRPRALSGIQPTSGSFHLGNYLGAIRQYVALQETHDAFYMVVDLHAITMPQDPKDLRANTRLSAAQLLAAGLDPERCTLFIQSHVPEHAQLAWVMNCITGFGEASRMTQFKDKSAKGGVNSASVGLFTYPILQVADILLYQANAVPVGEDQRQHVELTRDLAERFNHRYGQTFTLPAAHIVKEVAKIYDLQDPSIKMSKSASSPKGLISLLDEPKVTEKKIKSAVTDTEAEIRFDAENKPGVSNLLTIYSTLTGESIPALEAAYEGKGYGALKTDLAGVMVDFVTPFKQRTQEFLDDPETLDAVLAKGAEKARAVAAETLAQAYDRIGFVPAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBJ1</accession>
    <name>A0A0F4JBJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000472">
        <property type="protein sequence ID" value="KJY31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000472.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31732">
        <property type="protein sequence ID" value="KJY31732"/>
        <property type="gene ID" value="VR44_17615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8088"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9841" checksum="883984ECEC0910BD" modified="2015-06-24" version="1">MSRPWPTGLSAADLADYRQAQAEHEALMQQVADREFQIEAGLIESYADYCFAWQREDLEPPRPPTAAPDEEAGHGAWDGFDGEDCPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBX2</accession>
    <name>A0A0F4JBX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000474">
        <property type="protein sequence ID" value="KJY31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948472.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000474.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31700">
        <property type="protein sequence ID" value="KJY31700"/>
        <property type="gene ID" value="VR44_17640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19425" checksum="D9C8AA080F65A49E" modified="2015-06-24" version="1" fragment="single">RDRLVLPGLYDPAHASAMEPVWRPLSAVFAGIEQHGHDVIVDLGRRGAVGAPGVLAQKADAVLLVARNTLRGLQSAQVRLEALRESLGGATELGILLVDQGPFSKEEVRKHLGVTVTAVLPWRPKEAAVLSDGAEQPRRFESGELMRSARSAAVRVQELVAIRRSRLAPPSADAAQVVSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC52</accession>
    <name>A0A0F4JC52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000496">
        <property type="protein sequence ID" value="KJY31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948588.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000496.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a0f4jc52">
        <property type="family name" value="Duf_1023"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31394">
        <property type="protein sequence ID" value="KJY31394"/>
        <property type="gene ID" value="VR44_18245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="614" mass="65591" checksum="AE59BB4F347D779F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDJ5</accession>
    <name>A0A0F4JDJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000463">
        <property type="protein sequence ID" value="KJY31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948422.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000463.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31823">
        <property type="protein sequence ID" value="KJY31823"/>
        <property type="gene ID" value="VR44_17360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8008"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="29236" checksum="3602B332F82162B0" modified="2015-06-24" version="1">MAPTTTTPSPGTARAIRVVAHRGASHEYPEHTIEAYRRAIADGADALECDVRLSADGRLVCVHDRTVERTSDGRGVVSELTYAQLAAFDFGGWKGAEHRGARVLLFEDLLKEALAADRPVGLAVETKHPTRAGGRLEAELVRMLKEYGLADGSDGRVEVMSFSRNALTRLHRLAPGLPSVYLIERPLRAPRPPFAGHAGPGIDLVRRDPGLVGRLRAKGLRVRVWTVDEPEDVELCVRLGVETIITNRPREVREQLGARAVAAGADGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDN3</accession>
    <name>A0A0F4JDN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000519">
        <property type="protein sequence ID" value="KJY31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948724.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000519.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31076">
        <property type="protein sequence ID" value="KJY31076"/>
        <property type="gene ID" value="VR44_18945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8392"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470961" evidence="2">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="246" mass="25088" checksum="92886481BD2E5D21" modified="2015-06-24" version="1" fragment="single">FGTAAPFLTAALVVAVSALTALVLARAGHTPRDRVLAAWPELAPLPPAALGAGLLGALAYGEEYRYPALAADRGTVPRRLGLLTAKLGVCAALALLLGALAAATDAAALVLVFGRALGRAPLGSRPEWVVPAASWAGLLVGCAWAGVLASAVFRSASAGLAAVLAVPVMVVPLVRKALEGPSAYPAHGFASRLRGLASAPWPGETDRYVLGAFRVMVQPVGVALVLSLMVLLCAYGFTGLRGRVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE68</accession>
    <name>A0A0F4JE68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948072.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32647">
        <property type="protein sequence ID" value="KJY32647"/>
        <property type="gene ID" value="VR44_15520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7504"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16513" checksum="EE99FECB000B3BD5" modified="2015-06-24" version="1">MTPRTAPSGPLLKPRTMVLDSEALSKAARGDREVRGMIRRAPNREMRVVTSSLTTLEAWDPRAGVRQETWKWFLSSVDIVHTDDEIIKTARSLLKEAGLHGHKYAIDAVLASIAVVASRQGHLVNVLTSDLDDMKRLLGDHRIRIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFF6</accession>
    <name>A0A0F4JFF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000383">
        <property type="protein sequence ID" value="KJY32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32920">
        <property type="protein sequence ID" value="KJY32920"/>
        <property type="gene ID" value="VR44_14910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7398"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012363">
        <property type="entry name" value="PduX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF1">
        <property type="entry name" value="PTHR43527:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033887">
        <property type="entry name" value="PduX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="33182" checksum="AF7CBF3A08365434" modified="2015-06-24" version="1">MYSAPTDTVAGAAAVPLGSGSGSAFGTFGELLQGALPHPQGDFLVTFPLARWATAVFHPEPGGRVRVRPAHKAKSRRVAEAVLAALGTADGGLLEVAGDLPEGKGLASSSADLVATVRAVGAAHGRAFTPAETEDFLRGIEPADGVMYDEIVAFHHREVRLGRRLGVLPPLTVVAHDEGGQVDTVAHNRGARAIDAADREEYARLLARLTDAVACGDLAEVGAVATRSAEMNAQRRRRAGFAELHALCREVDGLGLVLAHSGTMLGVLLEADDPALAGKTEHIRAGCAPLGGEVSVHRSLGADDSWSPQTPPAHPAELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJA2</accession>
    <name>A0A0F4JJA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947915.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33026">
        <property type="protein sequence ID" value="KJY33026"/>
        <property type="gene ID" value="VR44_14635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7254"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="357" mass="38771" checksum="33E09460C247D5CE" modified="2015-06-24" version="1">MERDTSVQYDQQGGGRRPRRRQILIGGGLALVLAAGGGAAYGFGLFSDMGDPVSFGKIQESAAAEDIRPGVLMPTGPKSEFVRTSRLADGTQIAMTTLTGRKSGFTGDVWVWVPKEYDDPRYAKSGFPVLISLPGGRGYPKNYWGTGPGLGLQQAVTDGVKNGTSLPFILVMPVINADTKYHYDGSDIPGEPKMGTWMADDVPDFTRANFRTFTSRDGWAFMGSSSGGFGAFKHVLKYPERFKAAIASGVDFVPDSPLWKGNRQAMDENNPEKLAEKLIGEGGPDVYINFQIGTKESGRDLAEKFMKEYGKGPVHTRLQVIQDGEHNGKSYVRGMREGSLAWISKVMQAPTPDPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK26</accession>
    <name>A0A0F4JK26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000268">
        <property type="protein sequence ID" value="KJY34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34692">
        <property type="protein sequence ID" value="KJY34692"/>
        <property type="gene ID" value="VR44_11495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6201"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19533" checksum="EE416409C31CB660" modified="2015-06-24" version="1">MVGVIGGWETGVKATRKPRTGGWPWRPQWEELARLRVELEHRGLLREWGPVPADPPRAGQTAGVTGPHAGPGLTSRLVIALPETRWAPLVRGVHWTNQPHVEALQAWADRWGAGPAAEDGAAALRIYQDGDEHFTAGFTARWSNRAPPRLVRYGTSTTSAGSVRAAATRLLDVTGWGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKD5</accession>
    <name>A0A0F4JKD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000300">
        <property type="protein sequence ID" value="KJY34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947474.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000300.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34284">
        <property type="protein sequence ID" value="KJY34284"/>
        <property type="gene ID" value="VR44_12205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="14943" checksum="84F19E6A0587D427" modified="2015-06-24" version="1" fragment="single">MNPHDRLLLDAARAGDTDAVRAALAAGAAPETRDEDLRTPLLLAVLGDHVAAAEVLIAAGADPDAPDSREDSPWLVTGVTGSVRMMRALLPAGPDLKQRNRFGGVSLIPAAERGHVGYVRAVLAETDIDVDHVNRLGWTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMM2</accession>
    <name>A0A0F4JMM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947222.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35074">
        <property type="protein sequence ID" value="KJY35074"/>
        <property type="gene ID" value="VR44_10860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6052"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35402" checksum="7874B56AE2D705FE" modified="2015-06-24" version="1">MAGRFDPPTRTDLRAGRTPVPGGHGAAVGGGVRRLWRPEAPVDLGLVLGPLRRGPGDPTFRTTPDGSVWRATRTPAGPATLRVAVTPDGVDAEAWGPGADWVLDGLPALLGADDDPAAFVPRHRLVHASHRRRPGLRLTRTGLVLESLIPTVLEQKVTSDEAYRSWRRLVCRHGEPAPGPGGLYVMPSARAWALIPSWDWHRAGVDLKRSDTIVRAARVAARLEEAAAMELPQAAARLEAVPGIGPWTSAETLQRSNGAPDAVTTGDLHLPGIIGYALTGNRDADDEVMLELLAPYAGQRHRAARLILLAGRTPPRRAPRMYRSDISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN05</accession>
    <name>A0A0F4JN05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000202">
        <property type="protein sequence ID" value="KJY35747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946932.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000202.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35747">
        <property type="protein sequence ID" value="KJY35747"/>
        <property type="gene ID" value="VR44_09300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5187"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10588" checksum="B87757678D6ADB91" modified="2015-06-24" version="1">MNDGQGNVGINYGTIGGAAPDADQLRATVEELIRLLGELRPHLTPDQDRAVERALPVLTPDPGALRERGLVLGRLAQIAAAVGAVGQPAAEAVNRLFTLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNC9</accession>
    <name>A0A0F4JNC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_tran_28_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946870.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35882">
        <property type="protein sequence ID" value="KJY35882"/>
        <property type="gene ID" value="VR44_08955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4962"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="229"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="35548" checksum="F0B6FCB4DFC15101" modified="2015-06-24" version="1">MIGYYVHHHGLGHLHRALCIARHARSPVTGLSSLDPPPDWPGPWISLPLDTGGPAAVDTRAQGRLHWAPLFHDGYADRMSTLAGWLGRTRPTLLVSDVSVEVACLARLMGVPVVVAAMRGRRLDAAHRLGHDIALRLLAPWPATAPEPGWPSRWYDKTIYASAFSRDDGRVPTPPPRDGTRRVLLMLGAGGSGITFEQVRAARAATPDWQWDLLGGPGGAWSADPWTRICAADVVITHGGQNAVAECAAARRPTVVLPQERPYGEQHATGRALREAGLAVVREHWPDPPQWPSVLAEAAALDGDAWSGWAPGDGARRAARALDALAAMPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JND0</accession>
    <name>A0A0F4JND0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947156.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35263">
        <property type="protein sequence ID" value="KJY35263"/>
        <property type="gene ID" value="VR44_10520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5847"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="236"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="40470" checksum="90ADEB201DC97942" modified="2015-06-24" version="1">MTLPVVIVGGLHSDARKEVVERLLHTVPGSITLHHDLATAARGTVLRVVRDASGELSRSEAPLVNDCACCALREDLVPELGRLADSGLARLAVVELWDSVEPRAMAEVVAAHGAGAFDLTGVITAVDPALVLPYLVNGDDLADVGLAAAATDQRTVGDTWARQLEYAPVLALVDSGEADEEDRALLAQLHPTARRVDAASGELAALAFAGFDVEAAAGAQHPACALLPQEAEEAGVTTFVWHRRRPFHPERLYQALEDLCCAAARSRGRFWLADRPDTLLAWDAAGGALCVENAGPWLASLPDAAWELVPPMRRAAASLDWHPDHGDCCQHLVFTSPGLDRHGLERLLESCLLTDAEYAAGPDAWRSLPAAFDSLLDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNV4</accession>
    <name>A0A0F4JNV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000216">
        <property type="protein sequence ID" value="KJY35514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35514">
        <property type="protein sequence ID" value="KJY35514"/>
        <property type="gene ID" value="VR44_10005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5549"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="513" mass="54522" checksum="DDE4077825B292BE" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNZ7</accession>
    <name>A0A0F4JNZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946798.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36092">
        <property type="protein sequence ID" value="KJY36092"/>
        <property type="gene ID" value="VR44_08580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4858"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="284" mass="29188" checksum="11E0F9765E5D6072" modified="2015-06-24" version="1">MSIVVTAATGALGRLVVEELLTRVPAAELAVVVRDKDKAADLAARGIEVRVADYDDPASLAGAFRAGERVLLISGNEVGRRVPQHTAVIEAAAAAGVAQLAYTGILGGPEADFELATEHNATERAILDSGLPYTFLRNGWYHENYTAQLPVVLEHGAVVASAGEGRVASAARADYAAAAAVVLTGEGHLNRVYELSGDTAWSLSEYAAEVARQSGREVAYSAVPGDAHLEVLTGAGVPEGFAAVIVDVDAAISRGRLAGTSGDLARLIGRPTTPVAEAITAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP57</accession>
    <name>A0A0F4JP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000215">
        <property type="protein sequence ID" value="KJY35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947063.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7030"/>
    <dbReference type="EnsemblBacteria" id="KJY35533">
        <property type="protein sequence ID" value="KJY35533"/>
        <property type="gene ID" value="VR44_10000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5547"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="184"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="42079" checksum="DB55187146E86D6C" modified="2015-06-24" version="1">MTETLDTTPQTAREADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMKLVAYSGPENGSRETASYVLTNGSARFVLTSVIKPTTDHGRFIAEHVAEHGDGVIDLAIEVPDVRAAYAYAVEQGARGLDEPYEVKDEHGTVVLAAIATYGQTRHTLVERVDYTGPYLPGYVAVAPLVEPPAKRTFQAIDHCVGNVELGRMNEWVSFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTKKVKFPINEPAIAKKKSQIDEYLEFYNGPGVQHIALASNDIVATVRNMRAAGVEFLSVPDAYYDTLGEWVGDTRVPIDELRELKILADRDEDGYLLQIFTKPVQDRPTVFFEIIERHGSMGFGKGNFKALFEAIEREQEKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPX5</accession>
    <name>A0A0F4JPX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VR44_09150</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000198">
        <property type="protein sequence ID" value="KJY35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946902.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5114"/>
    <dbReference type="EnsemblBacteria" id="KJY35808">
        <property type="protein sequence ID" value="KJY35808"/>
        <property type="gene ID" value="VR44_09150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5094"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="16">
        <location>
            <begin position="137"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="35906" checksum="89DCF1F67AE4955A" modified="2015-06-24" version="1">MSPYGSDRSPRRPMRRKLLQALTAGVVLATATGCSYNWKSFPRLGMPYPATEEAPRILSLWQGSWAAALITGILVWGLIMWSVIFHRRSRTKIEVPAQTRYNMPIEALYTVVPLIIVSVLFYFTARDESKLLTLSAKPAHTINVIGFQWSWGFNYVENVDGDAATPKAGVVPKELASLPDRFTKDFPAGAEGVYEKGVPGDRNADTNNPGPTLYLPKGEKVRFILSSNDVIHSFWVVPFLFKQDVIPGHTNVFEVTPNQEGTFVGKCAELCGVDHSRMLFNVKVVSPAEYKAHLKQLAEKGQTGFLPAGIKQTDPARNAEVNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQN9</accession>
    <name>A0A0F4JQN9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946821.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36063">
        <property type="protein sequence ID" value="KJY36063"/>
        <property type="gene ID" value="VR44_08715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4986"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="11941" checksum="13FFC952FD4417B5" modified="2015-06-24" version="1">MTTALIDLRTVARNDWGLRLALAGELDFYTAGQLGPRLRELASCGYRNIVLDLRGLTFCDSAGIDLLIRFDRRCRTAGARLLLCDVPPLVVKSLRVLSADRDLTFTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR80</accession>
    <name>A0A0F4JR80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36695">
        <property type="protein sequence ID" value="KJY36695"/>
        <property type="gene ID" value="VR44_07370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3947"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="398" mass="42004" checksum="311E79996F8E9342" modified="2015-06-24" version="1">MAAGPPGPGVLGGMTYVPMTARSRVEGHRTATTLELFFDLCFVVAIAQAGQRLVHALAEGHPGGGVVGYFFVFFGVWWAWMNFTWFASAYDCDDVPYRVTTLVQIAGVLVYAAGVGRAFDTNDWTVAVIGYLIMRVALTAQWLRAAAGESGAARSAALKYAAGLVLCQAGWVALLFAPDAWKRWLFLVLVVAELLVPVVAESGHQTPWHAHHIAERYGLFTIIVLGETIAASTVAVKSAIDEHDALGVLLPIAAGGLLIVFAAWWIYFAVPVHERLTSNREAIPWGYGHLLIFASGAAIGAGIEVAVEHAVGNAHISQVAANAAVTVPAAVFLLMVWLLHSRHFKRGTAQQLVLPLTSVAILACTWAGSYAVLYAGLVAAAAVVAGTALVARSAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRN0</accession>
    <name>A0A0F4JRN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000212">
        <property type="protein sequence ID" value="KJY35596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947035.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000212.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35596">
        <property type="protein sequence ID" value="KJY35596"/>
        <property type="gene ID" value="VR44_09835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5467"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="159"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="30543" checksum="4F17882AAFE13764" modified="2015-06-24" version="1">MSSLAAPAPALAPRRAGLADLPVLLVAVVWGGSYLAAKGITTAHTVVAVLVLRFALVLPVLVLAGRRRLRALNAAQLRGAGLLGLVLGGIFLLETYGVVHTSATNAGLIISLTMIFTPLAESAVRRTAPSGAFLAAAAVSVTGVVLLTQGAGFTAPGAGDLLILGAALARTLHVLLMARIEAVRDADSLSLTTVQLGGAVLVFALLAALPGTGDSPWAVAADFGPAAWGGLAFLSLLCTLFAFFVQMWAVRRTSPSRVSLLLGTEPLWAAAAGIALGGEHLGAAGLTGAALVLAGTAWGRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSV4</accession>
    <name>A0A0F4JSV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946253.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2519"/>
    <dbReference type="EnsemblBacteria" id="KJY37422">
        <property type="protein sequence ID" value="KJY37422"/>
        <property type="gene ID" value="VR44_05655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1946"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27729" checksum="7FE8648DBCB0BDE2" modified="2015-06-24" version="1">MQSTPRPADEDQPVISLRGATASLGSRPVLRGVDLTVRRGEVVALLGANGSGKSTAVRAVVGQVPLTDGALSLFGTDFRRFRQWSRIGYVPQRTTAASGVPATVREVVSSGRLARSRFGILRGADRAAVERALALVDMDGYADASVNALSGGQHQRVLIARALAVEPELLIMDEPMAGVDLANQEVLANALREQVAAGTTVLLVLHELGPLEPLIGRAVVLRDGCVVHDGPPPEAVGQHALPGHDHVHPHAAHDAEPLRTGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX4</accession>
    <name>A0A0F4JTX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37817">
        <property type="protein sequence ID" value="KJY37817"/>
        <property type="gene ID" value="VR44_04895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1064"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="43439" checksum="7EF30636F9912155" modified="2015-06-24" version="1">MLISGASVAGPALAYWLHRHGFAPTIVERAPALREGGYAVDFRGEAHLSVLRRMGILDALRAARTGTGSMSYVNSAGKPQAKLPADLFAGDLEVLRGDLARILYDATKEHTEYVFGDSITSLSEDAEGVHVTFERGAPRRFDLVIGADGLHSRTRSLVFGPEERFVKHLGVYCAIFTTDNHLGLDRTGHAYVTPGRLVTVYSARQNREAKAVFYFGSPLLDLDRRDVTRQQALLTERFAGNGWESDHLLERMRQAPDFYFDSVGQVRMDSWSRGRVALLGDAAYCPSPLSGMGSGLALVGAYVLAGELAAARGDHRTAFARYEREMRVYAEGCQKMGDGVAKMMVPESRLLAGFLNRYYKVMPYLPGKNMPAKMARKAAENITLRDYTAELSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX8</accession>
    <name>A0A0F4JTX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266490.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5807"/>
    <dbReference type="EnsemblBacteria" id="KJY37289">
        <property type="protein sequence ID" value="KJY37289"/>
        <property type="gene ID" value="VR44_06160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2567"/>
    <dbReference type="eggNOG" id="ENOG502ZR3M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14696" checksum="9057EABFFD5987ED" modified="2015-06-24" version="1">MLSRFFAPKVKVSAHCDLPCGVYDPAQARIEAESVKAVQEKYQANEDADFRARAITIKEQRAELAKHHVSVLWSDYFKPPHFEKYPQLHTLVNDTLKALSAAKASNDPATGAKALELIAEIDRIFWETKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU25</accession>
    <name>A0A0F4JU25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946700.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36456">
        <property type="protein sequence ID" value="KJY36456"/>
        <property type="gene ID" value="VR44_07985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4421"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14351" checksum="4C64181BCDEFFF54" modified="2015-06-24" version="1">MIEVSGTEALWLLEGSAQGRLIYVQREVVVVRPAAHVMEYGRLVVRAPVQAATIPGRALLTYHVDEVRTPAGTGWTVSAHGPADVIADPDEAAHYRRTLPGWSHGPHDTLLRLRPQSVSGFRLARAVSEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUA0</accession>
    <name>A0A0F4JUA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37414">
        <property type="protein sequence ID" value="KJY37414"/>
        <property type="gene ID" value="VR44_05610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1935"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="34599" checksum="18D03A9C054C9139" modified="2015-06-24" version="1">MWETILSFHRLRDRRDARLFGEWRTEARSRLNGETRLLSALIPARGYFPDFLTPSEGQYGWDVGLDALRALSADRLRHELSLVGAGAGAGFGAAFGTPPPARLREFMDGGTKHLPRLLGELRGYHRAAVEPYWTHIQAQIEAERAARGRALLDGGADELLASLPPMLRWRAPVLECEYPVDRDVRLRGRGLLLQPSFFCRRTAVTLHDPELPPVLVYPAAAQLAPAGAGGEAARPEEQRQRTLGKLVGHTRSVVLRAIGDGATTSELARRAGVSLASASQHACVMREAGLVTTLRHGNAVLHTVTPLGAALLKGGAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUG6</accession>
    <name>A0A0F4JUG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_04520</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946040.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37987">
        <property type="protein sequence ID" value="KJY37987"/>
        <property type="gene ID" value="VR44_04520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.713"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471050" evidence="14">
        <location>
            <begin position="28"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="15">
        <location>
            <begin position="68"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY37987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="41731" checksum="8AF99D39275342B1" modified="2015-06-24" version="1">MPQPSRAAALPLAALALALLAAPTAQAAPALGPAGAGECTFPMKKQIADRPWALQRLTFDALWAQTRGKGVRVAVIDTGVDRANPQLAGALDAGAGRDFLDPKGGDGTTDTVGHGTKVAGLIAARPQQGTGFVGLAPEATVIPIRQNDGQGNGNAATLAQAIDHAVAKGAQVINISQDTDAPLTADSELAKAVQRALDAKAVVIASAGNDGLSGEKRRTYPAAFPGVLAVASSDRNNERAAFSQPGDFIGIAAPGVDMVSTVPGFGQCIDNGTSFSAPYVAGVAALLRAKHPDWSVQQVVWQIQNTAERSVKGRDDYVGWGVVDPVRALTQDREPPRPPVPDPGPPPAAAPQAVPLPLTETAQERDERIGTYALGITGLLIAVIAVTATVVREARRRVGRVGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUM4</accession>
    <name>A0A0F4JUM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_04750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946085.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37885">
        <property type="protein sequence ID" value="KJY37885"/>
        <property type="gene ID" value="VR44_04750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1030"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="977"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2499"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2477"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2574"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1012"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="2597" mass="279832" checksum="DD452BD49A08C551" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUM9</accession>
    <name>A0A0F4JUM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000102">
        <property type="protein sequence ID" value="KJY37524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946228.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4858"/>
    <dbReference type="EnsemblBacteria" id="KJY37524">
        <property type="protein sequence ID" value="KJY37524"/>
        <property type="gene ID" value="VR44_05515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1913"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="25865" checksum="37C1B73B0A9C2C78" modified="2015-06-24" version="1">MAVVDLSGKAVVITGGARGLGAAAAQAVVDGGGRVLITDVLEAEGAETAAKLGDAARFLRHDVTSEADWQAVLDHAVAEFGRLDGLVNNAGIATGQFLEHESVEHFRRCVEVNLVGTFIGLKAAIPLLRANGGGSVVNISSAAGLTGLALTAGYGASKWGVRGLSKIGAVELAEARIRVNSVHPGMTLTPMTAPVGIQAGEGHYPGTPMGRVGVPEEIAAAVAFLLSDAASYVTGAELAVDGGWTAGLTVRHLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUY4</accession>
    <name>A0A0F4JUY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoribosylglycinamide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946524.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4621"/>
    <dbReference type="EnsemblBacteria" id="KJY36796">
        <property type="protein sequence ID" value="KJY36796"/>
        <property type="gene ID" value="VR44_07115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3766"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="228"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="360"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="523" mass="55916" checksum="08EF65D6A5D1053D" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV16</accession>
    <name>A0A0F4JV16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946199.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7124"/>
    <dbReference type="EnsemblBacteria" id="KJY37684">
        <property type="protein sequence ID" value="KJY37684"/>
        <property type="gene ID" value="VR44_05335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1703"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15536" checksum="A6D604055F98D4B4" modified="2015-06-24" version="1">MVWSHVGLNCADQKSTEEFYTRYFGFTRARVVDLGESRIVFLRKGDAYLELFESAAGPARPAHDDGPPAPGRIRHLAFQTDSVDAFLAELGDAADVTLGPLDFDDFICGWRTVWVRDPDGVIVEVSQGFEDDRSHDKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVD3</accession>
    <name>A0A0F4JVD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_04860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37809">
        <property type="protein sequence ID" value="KJY37809"/>
        <property type="gene ID" value="VR44_04860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1054"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471277" evidence="8">
        <location>
            <begin position="43"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="203"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="755" mass="78208" checksum="504091E9972A577C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVL6</accession>
    <name>A0A0F4JVL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000067">
        <property type="protein sequence ID" value="KJY38412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945899.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38412">
        <property type="protein sequence ID" value="KJY38412"/>
        <property type="gene ID" value="VR44_03695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8277"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="25779" checksum="78E040E1D5446946" modified="2015-06-24" version="1">MGVLKGKTALVTGGSRGIGRAVAQRLARDGALVAVHYGRNEAAAKETVAAIESEGGRAFAIGAELGVPGDAQALWAAYEAHPAHTERVDVLVNNAGAAAFAGIGETDEETFQRVQAVNAQAPFFVIKHGLERLADGGRIVNVTGTPDIALPAILATIMAKGAVNALTVSLAAALAPRGITVNSVGPGITETELNAAWLADPAARAHAASRSVFNRVGTVEEVADVVAFLASPDSRWVTGQHLSATGGLQLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVP5</accession>
    <name>A0A0F4JVP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945942.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene754"/>
    <dbReference type="EnsemblBacteria" id="KJY38235">
        <property type="protein sequence ID" value="KJY38235"/>
        <property type="gene ID" value="VR44_03950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8695"/>
    <dbReference type="eggNOG" id="ENOG5033B7F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="21145" checksum="35B5EDD6B309983A" modified="2015-06-24" version="1">MSTTPPVLAAELAQAWADIQRYHPELPDLAAPESLIGESSSACGAELSFERLLHEAVHGIAAARGVRDTSRAGRYHNRRFLAIAEEMGLDHSEEPHASSGFSLVFLNPEAKRRYRPTIERLQRALKAHTAATAADTKRSFRGPAARHGSSGGGVRVKAVCDCGRNVRVVPSVLAQAPIVCGGCMKPFRIPEVATAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWW0</accession>
    <name>A0A0F4JWW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945940.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38233">
        <property type="protein sequence ID" value="KJY38233"/>
        <property type="gene ID" value="VR44_03940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8693"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="23870" checksum="831ACA85B8067FDA" modified="2015-06-24" version="1">MTPTPTATLVARDWAEIQERMLVPLYEAVYDRLEVGPGTRLLGLDCGAGLALLLAAGRGAAATGVEADPALRALARERLLEVVAAPPVPAARPYDVLLAFEPAPGALASALPAVRRGGAVVLAGWGPAERCTVPAVLGGGPVVRDLDAVAEGAGLVPDGSGRVFCPFGYADADSAVRGLLSTGLYPVAGTGAGPGAAADPALAEKELAEALHPYERADGAVWLPNILRYVIARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXP1</accession>
    <name>A0A0F4JXP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_03470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000062">
        <property type="protein sequence ID" value="KJY38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945859.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38493">
        <property type="protein sequence ID" value="KJY38493"/>
        <property type="gene ID" value="VR44_03470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="19006" checksum="4F60697C09540551" modified="2015-06-24" version="1">MRQGRRDGFREFAAGRSGPLYRSACLLASGDVHLAEDLVQETLGRMYLLWGRISRIDNPAAYAQTVLVRSFLTHQRRRSAGERPVGEFPESRAPEAGAADPELRVTLLQALGQLAPKDRAVLVLRYWEDRSIEETAEAMNVSSAAVRTRSTRALTRLRGQLGDSLSELVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXQ0</accession>
    <name>A0A0F4JXQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38614">
        <property type="protein sequence ID" value="KJY38614"/>
        <property type="gene ID" value="VR44_03230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="27487" checksum="FE2A0A82BC45814B" modified="2015-06-24" version="1" fragment="single">MQKAVSRDGTVIAYDRTGRGPALVLVGGAFQVRDHPSWIRLADLLGEQYTVVRYDRRGRGDSGDTAPYDVAREVEDLAAVMAELEGPVRVMGMSSGAVLALEAAARGLPIAELALYEPPFVVEDSRPPVPADYIGRLDALLAEGRRAEAVAYMLTTAVQVPAQHVEAMREAPLWDHFVAVAHTLAYDARVVGDTMEGRPLPADRWAAVDIPVLAIGGGASDTWLQAGARALADLLPTAVHRTLEGQTHDVDPAALAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZB0</accession>
    <name>A0A0F4JZB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000028">
        <property type="protein sequence ID" value="KJY39164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39164">
        <property type="protein sequence ID" value="KJY39164"/>
        <property type="gene ID" value="VR44_02045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5817"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014988">
        <property type="entry name" value="Uncharacterised_YqcI/YcgG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045">
        <property type="entry name" value="PTHR40045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08892">
        <property type="entry name" value="YqcI_YcgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="27846" checksum="F3E2EFEC3E634643" modified="2015-06-24" version="1">MVPQAQTTEFEEGWQRTAVEEITERLTAPDFPCVFSRNAFRKQLLRFVFVPDGGSGGIRHLAAALTEYVEEAGRWDGQLDTAYPLVVVFSPEAVAGESVEEYHAFGWHVLQELHRVDPAPWPAGVARQPGDEAWSMCFNGMPLFCNMSNPGHRIRRSRNLGRSFVLVINPRERFDVFAGDTPSGRKVRANIRNRIQRYDGVPHSPQLGSYGIGALEWHQYGLIEENTGRSDVCPFSPRIDDDTQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0A3</accession>
    <name>A0A0F4K0A3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">VR44_00045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945253.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene978"/>
    <dbReference type="EnsemblBacteria" id="KJY40057">
        <property type="protein sequence ID" value="KJY40057"/>
        <property type="gene ID" value="VR44_00045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.9"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY40057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="31085" checksum="B7AEB43227985C9F" modified="2015-06-24" version="1">MHRRHNGLKTAVLLGGMSALIIVIGSFFGRGGLIIAVLVALGTNAYAYWNSDKLALRAMRARPVSEFEAPELYRMVRELSTSARQPMPRLYISPTEAPNAFATGRNPRNAAVCCTEGILRILDERELRGVIGHELSHVYNRDILISSVAGALASVIMFLVNFAWLIPVGRSDDDEGPGILGMLLIMILGPLAASVIQLAISRSREYEADASGAQLTGDPLALAGALRKLDAGTKQLPLPPEPRLETASHMMIANPFRPGQGLTKLFSTHPPMAERIARLEQMAGRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0G1</accession>
    <name>A0A0F4K0G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_01220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945443.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39594">
        <property type="protein sequence ID" value="KJY39594"/>
        <property type="gene ID" value="VR44_01220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2960"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471527" evidence="10">
        <location>
            <begin position="45"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="11">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="12">
        <location>
            <begin position="360"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY39594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="664" mass="68704" checksum="CE839844E83FD3FA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K211</accession>
    <name>A0A0F4K211_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">VR44_00410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945292.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1050"/>
    <dbReference type="EnsemblBacteria" id="KJY39958">
        <property type="protein sequence ID" value="KJY39958"/>
        <property type="gene ID" value="VR44_00410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.80"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY39958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="340" mass="36670" checksum="D5519446172AA666" modified="2015-06-24" version="1">MLIAQRPSLTEEVVDEYRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRVDGVLHEFTTVPGVKEDVTDIILNIKQLVVSSEHDEPVVMYLRKQGPGLVTAADIAPPAGVEVHNPDLVLATLNGKGKLEMELTVERGRGYVSAVQNKQAGQEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLIVDVETKQAMRPRDAMASAGKTLVELFGLARELNIDAEGIDMGPSPTDAALAADLALPIEELELTVRSYNCLKREGIHSVGELVARSEADLLDIRNFGAKSIDEVKAKLAGMGLALKDSPPGFDPTAAADAFGADDDADAGFVETEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3P1</accession>
    <name>A0A0F4K3P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000007">
        <property type="protein sequence ID" value="KJY39796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945314.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39796">
        <property type="protein sequence ID" value="KJY39796"/>
        <property type="gene ID" value="VR44_00515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.103"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="21634" checksum="419DD94E212DA132" modified="2015-06-24" version="1">MTAPTAVLREMRWWDIAPVLELEHELFPEDAWSAGMFWSELAHARGPHASRRYVVAELPPDSGSAAGSSGRLVGYAGLAASGDLGDVQTIAAAKDQWGTGLGARLLTELLRAATDFECAEVLLEVRVDNTRAQRLYERFGFEPIGFRRGYYQPGNVDALVMRLTDPARTAEPAASATSTPENPETPETPEHPESSETHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K430</accession>
    <name>A0A0F4K430_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">VR44_00185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818557.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4K430"/>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1002"/>
    <dbReference type="EnsemblBacteria" id="KJY39916">
        <property type="protein sequence ID" value="KJY39916"/>
        <property type="gene ID" value="VR44_00185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.34"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25992" checksum="9D09819560A6C919" modified="2015-06-24" version="1">MKRSKTLRAADAKVDREKLYAPLEAVRLAKETSTTKFDATVEVAFRLGVDPRKADQMVRGTVNLPHGTGKTARVLVFATGDRAAAAEAAGADIVGDDELINEIAKGNRLNEFDAVVATPDLMGKVGRLGRVLGPRGLMPNPKTGTVTMDVAKAVTDIKGGKIEFRVDKHSNLHFIIGKVSFSDEQLVENYAAALDEIVRLKPSAAKGRYIKKAALSTTMGPGIQLDSNRTRNLLVEEDPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K453</accession>
    <name>A0A0F4K453_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">VR44_00300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007265904.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1028"/>
    <dbReference type="EnsemblBacteria" id="KJY39936">
        <property type="protein sequence ID" value="KJY39936"/>
        <property type="gene ID" value="VR44_00300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.58"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12715" checksum="A926FADF6A371D5F" modified="2015-06-24" version="1">MEARAQARYIRVTPMKARRVVDLIRGMDATEAQAVLRFAPQAASVPVGKVLDSAIANAAHNYNHPDASTLVISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I478</accession>
    <name>A0A0F4I478_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001751">
        <property type="protein sequence ID" value="KJY16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952696.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001751.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16479">
        <property type="protein sequence ID" value="KJY16479"/>
        <property type="gene ID" value="VR44_40450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="13910" checksum="806D5CB44DC2FFF1" modified="2015-06-24" version="1" fragment="single">MTPPPAYPDAYEDSYSEGDQPLVRPYAMTGGRTRPRYQLAIEALVSTTADPMHLSGLLPEHQRICTLCREVKSVAEVSALLSMPLGVARILVADLAEAGMVAIHQPGNGEAGGTPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4Z1</accession>
    <name>A0A0F4I4Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001840">
        <property type="protein sequence ID" value="KJY15831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000069_gene5842"/>
    <dbReference type="EnsemblBacteria" id="KJY15831">
        <property type="protein sequence ID" value="KJY15831"/>
        <property type="gene ID" value="VR44_40770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8096" checksum="1135345EDD90EED7" modified="2015-06-24" version="1" fragment="single">PQGAGYRPGEPWPALERPTWRPDIRAAVISTARVNMHRKMQKLATAAGLYPIAVLSDCAVYLSDGPSPLDFLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I783</accession>
    <name>A0A0F4I783_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_40385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001737">
        <property type="protein sequence ID" value="KJY16566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16566">
        <property type="protein sequence ID" value="KJY16566"/>
        <property type="gene ID" value="VR44_40385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY16566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="23851" checksum="C0E3A2BC7DBC5081" modified="2015-06-24" version="1" fragment="single">LRTRDQTPGLLRALVGTVRGRRGTAAAATGGDSSLAGRLAALGRAEQRAFLLDLVCTRAAAVLGHGGGGAVDSGRAFRELGFDSLTAVEFRNLLMAETGVRLSSTVVFDHPNPAALAEFLRTELVGEDTGAQSAAPVAAGDDEPIAIIGMSCRYPGGVESPEDLWRLVASGADGISGFPENRGWDLDAIYHPDPEHRGTSYTREGGFLHDVAEFDAEFFGISPREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7T3</accession>
    <name>A0A0F4I7T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR faimly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_39875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001654">
        <property type="protein sequence ID" value="KJY17699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5919"/>
    <dbReference type="EnsemblBacteria" id="KJY17699">
        <property type="protein sequence ID" value="KJY17699"/>
        <property type="gene ID" value="VR44_39875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6278"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY17699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8680" checksum="6F9E0AAE758BF7CB" modified="2015-06-24" version="1" fragment="single">MLETSARLLRLLSLLQAHREWTGADLAERLGVTPRTVRRDVDRLRGLGYPVNASPGTGGGYQLGAGAELPPLLLDDDEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9E5</accession>
    <name>A0A0F4I9E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001623">
        <property type="protein sequence ID" value="KJY18098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18098">
        <property type="protein sequence ID" value="KJY18098"/>
        <property type="gene ID" value="VR44_39685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="11521" checksum="EB343A15CEE1FBB9" modified="2015-06-24" version="1" fragment="single">ELDLLDGDGDGDGDDGDDGDDGRREGDAGGGRRPEAAPPGAAPTSDEASAKSALFSAGPPAPPRTLLDVFAASVRAHPDEPALDDGSARLTYRALAAEVERRRRVLAACGIGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IA39</accession>
    <name>A0A0F4IA39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001664">
        <property type="protein sequence ID" value="KJY17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17536">
        <property type="protein sequence ID" value="KJY17536"/>
        <property type="gene ID" value="VR44_39940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20918" checksum="D7E967F58F63ABE7" modified="2015-06-24" version="1" fragment="single">LPEFARRTAALTGPEQARAVLALVRAEAAAVLGHQDAGAVPADRAFRELGFDSLTAVELRGRLARATGVRLPATLVFDHPSPAALAAHLLGELTAAITGRAAAPAPTATAARGADDAEPLAIVAMSCRYPGEVRSPEDLWRLVAEGRDAVGAFPSDRGWDLDSLYDPDPDRPGTTYARDGGFLYDVADFDPAFFGISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFK8</accession>
    <name>A0A0F4IFK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_39105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001551">
        <property type="protein sequence ID" value="KJY19421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952447.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001551.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19421">
        <property type="protein sequence ID" value="KJY19421"/>
        <property type="gene ID" value="VR44_39105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5583"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY19421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="29893" checksum="CB8987C82D5D8022" modified="2015-06-24" version="1">MAKIEFQSVTKTFPVKGRSKEEFTALDGIDLEIGAGEFLVVVGPSGCGKSTLLDLLGGLTRPTSGQILLDGRPVTGPGLDRGIVFQQYALLPWRTALGNVEFGLEAIGVPRRQRAARAREFLELVGLSGFEDRHPHELSGGMRQRVAIARSLAYDPDVLLMDEPFAALDAQTRESLQDELRRIWQSTGKTVVFITHGIEEAVYLGQKVAVITSRPGRVKEVVPVSFGDRSTGATGEDLRSSPEFARYRHEIWTLLHDEVARAQQLEKEEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGF6</accession>
    <name>A0A0F4IGF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001539">
        <property type="protein sequence ID" value="KJY19741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952426.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001539.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19741">
        <property type="protein sequence ID" value="KJY19741"/>
        <property type="gene ID" value="VR44_38995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5558"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="432" mass="47345" checksum="42666352A18BA122" modified="2015-06-24" version="1">MDATDLDGRFRSYRRCITPYLVSRLLELGYAEEVALQAGRGEWFCAQELARRLAGRERWAEAWEMLAPYVATGWWTAVEAAAGLLEAWGKPDEAIALARPHAEGGDRLARAAFARLLARNGRAGEAYELLLPHVEDDFLATALVDVAGPAGRDEDLAALLEARIAAGHRREDPACRWTAPSPAVAVSLLATVRERQGRVDDAVALLRPHPTDSPVHGHQQLADLLARHDRMEELRTYAAELAQPAERLAELLEERGDVEGAIAVYRLPEGSPDIRRDRALRLAELLERHGRGEEAIAVVRPLADVPPGPEDWLVRRLCSLYADHGRPAAGLDFLDTLNPRDSDEAWAFFEARLPLLAACGRSEEAIELVRTHPEGDTWYAASALARLLAGAGRLEEAVVVLGAHVSGNSADLAEHLITLGRVEEALTVLQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKL0</accession>
    <name>A0A0F4IKL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001416">
        <property type="protein sequence ID" value="KJY22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952216.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001416.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22575">
        <property type="protein sequence ID" value="KJY22575"/>
        <property type="gene ID" value="VR44_37870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5134"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="32882" checksum="1FB9267D72986532" modified="2015-06-24" version="1">MLDVRRLRLLRELARRGTIAAVAEALAYSPSAVSQQLAVLEREAGLPLLERTGRRVRLTPAAQNLVGHAEAVLERLEQADADLAEARSGLAGVLRIGAFPTATRALVPAALVDLARRHPALEPMVHETDPAAVAHALRAGDLDVALVHEYDFVPAAPEPGLATRPLYGEAMYLAAPRPEAAPAAGPGTAGHDQGEVLRGHRDAPWITATPGTLCHAMTLRACQAAGFTPRVRHRVDEFATVLALVAAGQGVAVVPQLGVTGPPDPAVALTRLHMERRTKIAFRSGAGAHPAVAAFAASLRAAVPQDLAEPRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INW4</accession>
    <name>A0A0F4INW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001381">
        <property type="protein sequence ID" value="KJY23717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952142.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001381.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23717">
        <property type="protein sequence ID" value="KJY23717"/>
        <property type="gene ID" value="VR44_37495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4918"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469999" evidence="1">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="13646" checksum="B184029216F9433D" modified="2015-06-24" version="1">MLKKFMATAAVTASILGTGALAATPAMAIGNDNGVNTVNGNGSQQIYGNAETAGAMSPQLDLVQGSLNKLCIGLPAKVNVQSVLSAVNIGVQDIPIASNPQNQQCAENSTQAKGDETLSHILSNIPVLSGNLSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQG5</accession>
    <name>A0A0F4IQG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001264">
        <property type="protein sequence ID" value="KJY24237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951856.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001264.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24237">
        <property type="protein sequence ID" value="KJY24237"/>
        <property type="gene ID" value="VR44_35950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4348"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="45436" checksum="2B11CF0834157C5B" modified="2015-06-24" version="1">MCELLNRIWSRPRGEWTRVVRRELPALAAEIVEELLQGIPGFSTLVDGNDAVDDDLIRQRVEEALLTALGYRDEPARDGAVGEDKDVLGARLDGGPDGGHGAGLDGGLDVRHDGRREEPHGGAPEAVRGAGHEHGPGHGDGHGHGHGIRHETAATAPDRVRQELFKALTDDRAASQDSLDDLARSAGWPLPAAVRAVALATPGEAQQLAAVLDDALAGMFAGRPCLLLPSPDADARAALDPLLRGRFAAVGHAVPLRDTASSLRWALRLLTLTPARGGLDARAVFVDDHLSTLLLLQDEPLAHALAARWLRPLADLTPRQSERLEVTLLAWLEGGGAPEAAKALNVHPQTVRYRMRQLEKLFGPGLRDPRTRFELEMALRSRRLMAQVRRQHSRVARRAARVVGADFPPLAVGRMARVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS29</accession>
    <name>A0A0F4IS29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001163">
        <property type="protein sequence ID" value="KJY24830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24830">
        <property type="protein sequence ID" value="KJY24830"/>
        <property type="gene ID" value="VR44_34215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3814"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21294" checksum="1ABD7F234A951517" modified="2015-06-24" version="1">MYVMDMPEEAWGRAAPHLREIALFLSVHLDRAPGVLWPEYDNPAFGDIDDGDDTVDALDALDAVYDEGAGEAEDADDTGAGSAGGGVCPAQVDRFTTELASLTGLSVRLDQVETAGDAPGAGEDPAWTRQPGGREHLLIHQLAGAVTWQLTRTGESGRPDSFQCRLLPGEVLYVPAGWSRRRVGAPQARCVVICLADKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS94</accession>
    <name>A0A0F4IS94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001215">
        <property type="protein sequence ID" value="KJY24514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24514">
        <property type="protein sequence ID" value="KJY24514"/>
        <property type="gene ID" value="VR44_35155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4109"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="30216" checksum="ED9F24891A569284" modified="2015-06-24" version="1" fragment="single">MVDQLLTAGIAAAAGVAVYLGAATRVVKQYERGIVFRFGRLRKGVRPPGLAMIIPVADRLHKVNLQIVTLPVPAQEGITRDNVTVRVDAVVYFKVVDPASALIAVEDYRFAVSQMAQTSLRSIIGKSDLDDLLSNREKLNQGLELMIDSPAMGWGVQIDRVEIKDVSLPETMKRSMARQAEADRERRARLINADAELQASHKLAEAAEVMSDQPAALQLRLLQTVIAVAAEKNSTLVLPFPVELLRFLERATPTPTPPATTAPPEPLPATNPPEPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT24</accession>
    <name>A0A0F4IT24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001194">
        <property type="protein sequence ID" value="KJY24613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951650.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001194.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24613">
        <property type="protein sequence ID" value="KJY24613"/>
        <property type="gene ID" value="VR44_34860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4043"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="16890" checksum="D5793064F22C9EEE" modified="2015-06-24" version="1">MPTWALLLEQNIHRRHGSAWSVTVLGHVDGTREEALTALRERVDRFDPSVFYTVKRRRLYGDGDGFMLLVEGRFARAWHYRFKLAELLEDSAPPPPPPEPKPEPVERWQPPRPRSPKPPKPPQRPAPPREVDIPERPAWLGRDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITI2</accession>
    <name>A0A0F4ITI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001316">
        <property type="protein sequence ID" value="KJY23986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951992.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001316.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23986">
        <property type="protein sequence ID" value="KJY23986"/>
        <property type="gene ID" value="VR44_36680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="13043" checksum="03007ADE358252C8" modified="2015-06-24" version="1" fragment="single">MSQRPIGSSGPASPAVAEMSELIELLEVVWERGRDTASAPPVSSAQARVLFLVEANGRLNLRELGRLLEAAPSSVTRLCDRLQAVGFLERHPGADDRREVLLRLTPAGLTYLGRLRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITZ3</accession>
    <name>A0A0F4ITZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001279">
        <property type="protein sequence ID" value="KJY24161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951900.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001279.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5266"/>
    <dbReference type="EnsemblBacteria" id="KJY24161">
        <property type="protein sequence ID" value="KJY24161"/>
        <property type="gene ID" value="VR44_36180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7248" checksum="5286C8A26254209A" modified="2015-06-24" version="1" fragment="single">MALGTVKWFNSEKGFGFIEQDGGGPDVFAHYSNIAMQGFRELQEGQRVSFDVTQGQKGPQAENIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU12</accession>
    <name>A0A0F4IU12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001116">
        <property type="protein sequence ID" value="KJY25139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951368.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001116.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25139">
        <property type="protein sequence ID" value="KJY25139"/>
        <property type="gene ID" value="VR44_33295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3535"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="36778" checksum="6C4AE2E0E463BB30" modified="2015-06-24" version="1">MHAGAWWLWALGLATAASRTTNPLLLGLIVGVAGYVVAARRTEAPWARSYGAFLRLGLFVIGLRLLFSVLLGSPVPGAHTLFALPELPLPAWAQGIRFGGRVTAEQLVFAFYDGAKLATLLACVGAANALASPARLLKSLPAALYEAGVAVVVAMTFAPNMVADVARLRTARRLRGRPTGGVRAVLQIGLPVLEGALERSVAVAASMDARGYGRTARVAPAVRHTTNALTLGGLLGLCAGTYALLAAEGAVYGLPLLGVGLLLALAGLRLGGRRSIRTRYRPDRWGARAWLVSGSGAAVAALLVHAGSVDPEGLRPGVVPLVAPGLPLWPAAAVLLGLLPAFVAPVPSLSSKESFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU67</accession>
    <name>A0A0F4IU67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001057">
        <property type="protein sequence ID" value="KJY25555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25555">
        <property type="protein sequence ID" value="KJY25555"/>
        <property type="gene ID" value="VR44_32150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3149"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="10793" checksum="A387952A804345D0" modified="2015-06-24" version="1" fragment="single">SAVLGLLAIADPANLDHTRLAEAALHSAETRADLKGACDALRVLGSAALTPEQHGRLAALTGRDRRLVLYGSDHAMIREDEQLRAALTSALPAAAAAARDTAGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUC1</accession>
    <name>A0A0F4IUC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001102">
        <property type="protein sequence ID" value="KJY25244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951314.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25244">
        <property type="protein sequence ID" value="KJY25244"/>
        <property type="gene ID" value="VR44_33015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3475"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="30247" checksum="CF3F46FFC4CA79BA" modified="2015-06-24" version="1">MMNNPPEEPPPAVHARGLTVRRGTGRRPRTVLDAIAFEVPRGRITGLLGPSGCGKSTLMRTVVGTQAHVTGTLDVLGRPAGHPELRSRIGYVTQAPSVYDDLTVRQNLDYFAAVLDPGRAAADRRRAAVDRAIADVDLTGRATALAGKLSGGQRSRVSLAVALLGTPELLVLDEPTVGLDPVLRRDLWNLFHEITETRGVTILVSSHVMDEAERCHDLLLMREGRILAQDTPEALRTRTHGATVEEGFLRLVDEANARADARADARAESPTGTLETETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUD0</accession>
    <name>A0A0F4IUD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent carboxylate-amine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001048">
        <property type="protein sequence ID" value="KJY25612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25612">
        <property type="protein sequence ID" value="KJY25612"/>
        <property type="gene ID" value="VR44_32050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="23776" checksum="7766B2DEFA0A786B" modified="2015-06-24" version="1" fragment="single">MSGAEVLLMVDDRPSSFTRYAARELAGRLVLLRFADTRPDLPEDHLRETAHLPAFWVREDAAPAEEARRYREWAAGLPAAPTRFCNPSEPRQAAAQRFARLAGLPHLTERQVALVRDKAAMKDCFRELGLRTAEFERVGSAAGIERFAGRHGWPVVLKPVDSFACVDTHRLDGPDDLAGIDLAARDWMVEAYLGGTEWEVCAIILGGEVLDAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVB2</accession>
    <name>A0A0F4IVB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001192">
        <property type="protein sequence ID" value="KJY24626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951635.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001192.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24626">
        <property type="protein sequence ID" value="KJY24626"/>
        <property type="gene ID" value="VR44_34780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4027"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="33065" checksum="0C8E2BCA2E16E502" modified="2015-06-24" version="1">MPPALWSLEGAAVTPRFPPGDIGGAAYFEERGGGLAAYDIVSGRRRWRGPAVREVWGGSRPIALDTDGTVLFLAAANGAVLKRIKADADRLLAVDRDTVYVLDRAGEIRALRSADGTQRWHGKLPVPGPVAAAGGHGLVTVVSATGAVAALSAADGARMWRYDISGADRPAPDTEACRPAMSSEAVVLGGGAALTALAPRGGGRLWQLAADERAGFGEPTATGDKLYVRDGAQLRAVDAVTGKAAWTVAAGAELAPRPGPLVVGAGVHAALANPELGILAVHTGRAAAQYVFAPALASAAPWQGAAVAGRVVWQRGSSVSALPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVU3</accession>
    <name>A0A0F4IVU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin biosynthesis-like protein MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_30820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000979">
        <property type="protein sequence ID" value="KJY26127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950911.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000979.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5715"/>
    <dbReference type="EnsemblBacteria" id="KJY26127">
        <property type="protein sequence ID" value="KJY26127"/>
        <property type="gene ID" value="VR44_30820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2621"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="392" mass="42607" checksum="C18576FA4D7F812A" modified="2015-06-24" version="1">MSLPPLVEPAAELTVDEVRRYSRHLIIPDVGMDGQKRLKNAKVLAVGAGGLGSPALMYLAAAGVGTLGIVEFDEVDESNLQRQIIHSQSDIGRSKAESARDSVLGINPYVNVVLHEERLEAENVMEIFSQYDLIVDGTDNFATRYLVNDACVLLNKPYVWGSIYRFDGQASVFWSEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVTEAIKVLTGVGEPLVGRLMIYDALEMQYRQVKVRKDPDCAVCGPNATVTELIDYEAFCGVVSEEAQEAAAGSTITPKQLKEWIDEGENIEIIDVREKNEYEIVSIPGAKLIPKGEFLMGTALQDLPQDKRIVLHCKTGVRSAEVLAVLKNAGFADAVHVGGGVIGWVHQIEPEKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVY6</accession>
    <name>A0A0F4IVY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001023">
        <property type="protein sequence ID" value="KJY25799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951051.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25799">
        <property type="protein sequence ID" value="KJY25799"/>
        <property type="gene ID" value="VR44_31590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2815"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469861" evidence="2">
        <location>
            <begin position="37"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="22277" checksum="081DCF5BC6500AE2" modified="2015-06-24" version="1">MTTFSKAGARLGMLPLAVVLLLAAGCGTQRGGGAAGADRGSDPTPSGVAAPSAPADFPCPDESHAPATPSTPTAPVTPRPTEPSAAASPRAAEPGETVTSGPAAPPADHYAENHAFRVPLPLHGQSRCDGLAAVGRVERALEPLRRRGDFAPESVRTALTSLGYAAGKVRTYQNGPTGVGFLVDVGASPWCVEGTMSSASTRAEAFGGYPDGTGCEPPRGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW92</accession>
    <name>A0A0F4IW92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951089.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene99"/>
    <dbReference type="EnsemblBacteria" id="KJY25728">
        <property type="protein sequence ID" value="KJY25728"/>
        <property type="gene ID" value="VR44_31790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3069"/>
    <dbReference type="eggNOG" id="COG4326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="28514" checksum="8990B1716712CDD2" modified="2015-06-24" version="1">MGFRKLLASLGAGGASVDTIITEPNVVPGGIVQGEVRIQGGSVEQQIEGLSVGLQARVEVEGGDHEYKQDIVFTKQRLGGAFKVQPNALHVVPFALEIPAETPITHFEGHPLHGMSIGVSTELEIARAVDAGDLDPINVHPVPAQQAILDAFRQLGFGFRSADMERGHIRGTRQTLPFYQEIEFLPPSQYRGLNQVELTFVSDGHEMDVVLEMDKKPGLFSEGSDTYRCFQVGLHSYEGTDWAAYLNQWIASVGSQRNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXN1</accession>
    <name>A0A0F4IXN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000970">
        <property type="protein sequence ID" value="KJY26218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950873.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000970.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26218">
        <property type="protein sequence ID" value="KJY26218"/>
        <property type="gene ID" value="VR44_30615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2576"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27816" checksum="2D2FCFDBD9B5B22A" modified="2015-06-24" version="1">MTATTSTTVANLRDLGGTPLAGGRTVRSGLVLRSAALDRLDLDADPAVAALGLRTVIDLRSDAERADHPDRIPEGARLLVRDVLADKITESRMPAAAQLKDLLADPVAADEHLGDGKAQALFGSVYRSFVTTASAHAAYRTLLMEAADPEAGPLLFHCTAGKDRTGWGATVLLSLLGADDETLMAEYMAVNPAVKAAFAPLIEGFTAAGGDPDIALALIGVFPSYLEAGLDELYLRFGSMEKYVRDGLDVPDETVEALRARLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY50</accession>
    <name>A0A0F4IY50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001050">
        <property type="protein sequence ID" value="KJY25601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951144.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25601">
        <property type="protein sequence ID" value="KJY25601"/>
        <property type="gene ID" value="VR44_32090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3136"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="34076" checksum="7541C3EF1E3981D2" modified="2015-06-24" version="1">MKAIVQDRYGSSDVLEFKEVDRPAPRDGEVLVRVRAASVNARDWHVMRGDPYVARLAFGLTRPRQPIQGTDFAGVVEAVGRGVAGLRPGDEVFGEAGGAFAEYVCAPQDAVGPKPAGLTFEQAAAVPLAGNTALMGLRDLGRLRPGQHVLVNGASGGVGTFAVQIAKALGAEVTGVCSTRNVDLVRSIGADHVVDYRQEDFTRTGLRYDLVLDLVGNRTLADLRRALTPGGAVVLSGGGVSEGGSLFGPMGLIIRGKLMSRLGRGRIHVLTAKASADNLAALRELVERGALAPAVDRTYPLSEGAEAVRYLEMEHASAKVVITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYL0</accession>
    <name>A0A0F4IYL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001027">
        <property type="protein sequence ID" value="KJY25761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951066.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25761">
        <property type="protein sequence ID" value="KJY25761"/>
        <property type="gene ID" value="VR44_31670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3043"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="226"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="576" mass="60622" checksum="2BAA52E10E8862C5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYQ5</accession>
    <name>A0A0F4IYQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000903">
        <property type="protein sequence ID" value="KJY26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950607.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000903.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26794">
        <property type="protein sequence ID" value="KJY26794"/>
        <property type="gene ID" value="VR44_29150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2173"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="32701" checksum="BA1E3842F3A6D9DA" modified="2015-06-24" version="1">MKRIQRAAGAVIGSAVGDALGAPFEFGPQGVFSARFPTPGAGGEMCGGGGWDPGEATDDTQMAVLVADSLLERGGLDLPDIFARFQRWAAAEPKDIGLQTEDVLTNGMPWDLAAAFHFQVNQRAAGNGSLMRASTSAVHFAAAGQEATMEAARRIAALTHGDRAAWEGTAIFHELIRVTFEDRDPLTALPDVLALVHPDHRGRYATVLTPDWHPDQATEFNGAVWPCLGSAVWALRTTTTFEDAIRAAIDLGGDTDTVAAVTGGLAGAYHGLDAIPAHWTQPLHVPLPGFDGRVLHLPDLLHLTHRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYV9</accession>
    <name>A0A0F4IYV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_31410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001017">
        <property type="protein sequence ID" value="KJY25861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951016.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25861">
        <property type="protein sequence ID" value="KJY25861"/>
        <property type="gene ID" value="VR44_31410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2772"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="490" mass="49806" checksum="D5B930F0C0C0B9B3" modified="2015-06-24" version="1">MPSAIAAGRPSPHARLVVPVLAFCGMVVAVMQTLVVPLLPHVPALTGASPGAAGWLVTITLLTGAVFTPVLGRVGDMYGKRRVLLASLGVLTLGSVLCAVSSDIGVLIAGRGLQGAALAVIPLGISIIRDELPVERVLPSIALMSSTLGIGAAIGLPVAAVVMENSDWHTMFWASAALGLLDLLLVLRIVPESPVRSPGRFDLPGTLGLTGCLVGLLLAITRGADWGWGSARTLGLLGASVAVGLLWGRYELRTRSPMVDLRVSARPAVLLTNVAALLIGFSFYANSLVTGQMVQEPTSTGYGIGASMVVSGLCLLPGGLAMVALSPVSARISAAYGPRTALALASVVMAAGYAVRFFTSHSLWMIVAGATVVSSGTAIAYSALPALVMRAVPVGETAAANGLNTLMRSVGQACCSAVVAAVLAHLTFTAGGRTAPTLHAYLLVFLIAGATALAALAATLFLPSDRPRERGAQEGTVTVSASETAARESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZH1</accession>
    <name>A0A0F4IZH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000838">
        <property type="protein sequence ID" value="KJY27412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950329.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000838.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27412">
        <property type="protein sequence ID" value="KJY27412"/>
        <property type="gene ID" value="VR44_27615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1758"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19267" checksum="B2A9AE5419CD31FC" modified="2015-06-24" version="1">MAERLLHPVNARLDEHLPTDHKLSKVYRVGAGLTGLLLIVFGILGLVHHIGFFDTGGDTVLALNTNGALSVLSICFGGLLFAGMVIGGTFASTLNIVLGLLFIASGFVNLALLDTGLNFLAFKIQNVLFSFFVGVMLMWFGMYGRVGSALPHDNPYWRARHPEQAAREDRARGRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZV3</accession>
    <name>A0A0F4IZV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000879">
        <property type="protein sequence ID" value="KJY26998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950510.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000879.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5478"/>
    <dbReference type="EnsemblBacteria" id="KJY26998">
        <property type="protein sequence ID" value="KJY26998"/>
        <property type="gene ID" value="VR44_28630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2055"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="419" mass="42573" checksum="FB3936CFD31A63C8" modified="2015-06-24" version="1">MGASTPSSPEPLSPGRPGYRRMSLALFAAGLATFALLYSTQALLPAVSAGFGVTAGQASWTVSAATGALALFVLPLSALSERFGRTRMMTCSMVVAVGVGLLVPFAPSLEWLVALRAVQGAAIAGIPASAMAYLAEEVRPKALVGAIGLFVAGNSIGGMSGRIVTGWGAQGWGAQLWGWRGGLLAVGVMALVSAVAFLVLLPRARFFRPASLNPRAVGRTVAGHLRDPLLLRLYGIGALFMTVFGAVYTVIGYRLVEAPFSLGQGVVGSIFLVYLVGTASSAAAGQLVARAGRRGALYLAVTTTALGLLLSLADSLWLILPGLVLITAGFFAGHAVASAAVSRTAKTGRAQASALYQSAYYLGSSAGGTLGALAYHASGWAATVGIALLAVLGVVSITLYGSHAARAERRLPGAAVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1M6</accession>
    <name>A0A0F4J1M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000755">
        <property type="protein sequence ID" value="KJY28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000755.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28177">
        <property type="protein sequence ID" value="KJY28177"/>
        <property type="gene ID" value="VR44_25955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1291"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470307" evidence="2">
        <location>
            <begin position="27"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="27340" checksum="C267201CFC1FD0F5" modified="2015-06-24" version="1">MRTVRTLAAALLAGAALLAPAAAATAAPSPTPSPGGGTGKDGSAPTEAGTGFRTAALFRPGQKATASASTGDYLYWAVPADTGQRLTVRATVTLPESAARHGAQTWQLDLYDGLRRRQACTYGNQHVAAAKEAASVELSCTLRTVRSGAEPWSNDPLPGSYYVRLTVVGVPEDDHGLPVKAQVEAEVKETGGAQAVDAALAEPLVPGIAGASEQQREARAPEGGWSGGWWSDRWLWTAAGGVLGALAGIWGYSVTRGSGRPARPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J262</accession>
    <name>A0A0F4J262_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000735">
        <property type="protein sequence ID" value="KJY28402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949923.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000735.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28402">
        <property type="protein sequence ID" value="KJY28402"/>
        <property type="gene ID" value="VR44_25440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1184"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="23686" checksum="96FEB3EF94C30349" modified="2015-06-24" version="1">MNPILRALERFHAARPWDHNAHYHPWILRQLPRRFGSALDVGSGSGDLARLLASRAEAVHGVDVDAAIVARARELTAPAAAVTFTLGDALEELPPGPHDVITCVATVHHMPFGDALACFRRHLAPGGRLVVVGLFRPRSWTDYLIDAAAIPANIAMAWIKNKGRQAPRPAAMTAPTRPADMAFADIVREAHRVLPGARLRRRLFWRYTLVWHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2A0</accession>
    <name>A0A0F4J2A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-protein synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000876">
        <property type="protein sequence ID" value="KJY27041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950489.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000876.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27041">
        <property type="protein sequence ID" value="KJY27041"/>
        <property type="gene ID" value="VR44_28510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2030"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="73"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="42554" checksum="013136B1FF621787" modified="2015-06-24" version="1">MNPHLAPVAVPDPALLPHVQQLCDLTDPYASGPAEDELFAAAMAETNAWHADRSPFFRSLYEATPPAEPYRTPLVHANFFKRHEVLSVPREDVELHLTSSGTTGQKSQMFFDHWTIRSAQRMVARIFDRHGWITPDQEVNYLLYSYEPAPSLNLGTAFTDNYLCDFAPARSVAYALRNTGGDHEFDPFGCIAALRRFEREDAPVRILGFPAFLFFTLERMRAMGLPPLRLPEGSLVVLGGGWKGHSDRRIGKEELYARVTEQLGIPAERIRDTFGSVEHCIPYIECDHHRLHAPVWSRVTIRSTRTLEPLPYGEPGYLHLVSPYITSVPAQSVVMGDLASLQPGEACGCELGTPWFTVHGRAGVSRNRSCAVAAAELMKGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2E2</accession>
    <name>A0A0F4J2E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949917.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000734.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1614"/>
    <dbReference type="EnsemblBacteria" id="KJY28420">
        <property type="protein sequence ID" value="KJY28420"/>
        <property type="gene ID" value="VR44_25405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1177"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="97"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="40822" checksum="09D333D6937E8235" modified="2015-06-24" version="1">MYAATSSVSAPVRPHRTLQAGGGGLSFEPGRQPVPAQGAVRARRMPAAGTQPLSGRIDLSGPQGAQLRTALASVQRICPEFAPVQVLRRSGRSVLLVGTTGRMTAVAKVLLDHSPEWRERYRHEIAAYRTFVRHRPPVRVPRLIAADPENCVLVVERMAGRVAALQRHPVEAPPRTDVRAALGAVCRVNQWRPPADLFGHPVDYARRISRDHDLGLLTDRDYGDLQKLLHGLRPAGTPWQFNHGDALLSNLLLSPAGPVMLDWEHAGWYLPGYDLATLWTVLGDAPAARSQISRLAQSAGPAARDAFLVNLMLVLTREIRMCETAVQRSMLAAPAAQPLPAGALSSGEEQRLLLRRLHDDAGMARRAVRAAVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4D9</accession>
    <name>A0A0F4J4D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000796">
        <property type="protein sequence ID" value="KJY27801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950165.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000796.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27801">
        <property type="protein sequence ID" value="KJY27801"/>
        <property type="gene ID" value="VR44_26720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1503"/>
    <dbReference type="eggNOG" id="ENOG50336AB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23769" checksum="1298E0E62A2FCB84" modified="2015-06-24" version="1">MSDAALPTVAEVRAAAEAVKAALDRHLAAVESRIGDEDPAVYAAFNELAAAAEEYDELLYDRYDEVTPFEIPTPETGARYTGPAEPAAFSVLIRRDYAVVEPARLIAQAERVAAHDRDAELIDDGGTGGALGVLFGEYEPDEIASRSKDFGLEEGDSTLWIAALEEVAEPGDWLASPFGQTDPQDVLHRFDVSSVFDEDAEYFEDDDTDESPAAPTGLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4V9</accession>
    <name>A0A0F4J4V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000702">
        <property type="protein sequence ID" value="KJY28783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949762.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000702.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28783">
        <property type="protein sequence ID" value="KJY28783"/>
        <property type="gene ID" value="VR44_24570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.909"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470378" evidence="4">
        <location>
            <begin position="28"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="5">
        <location>
            <begin position="107"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="587" mass="63059" checksum="4E3FBAD2AF310883" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J591</accession>
    <name>A0A0F4J591_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000685">
        <property type="protein sequence ID" value="KJY28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28994">
        <property type="protein sequence ID" value="KJY28994"/>
        <property type="gene ID" value="VR44_23985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.775"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="553" mass="61933" checksum="8AA1DBD59DC921B8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7C9</accession>
    <name>A0A0F4J7C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000698">
        <property type="protein sequence ID" value="KJY28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28846">
        <property type="protein sequence ID" value="KJY28846"/>
        <property type="gene ID" value="VR44_24360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.854"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="PTHR14209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22972" checksum="F88CCD779871CB3B" modified="2015-06-24" version="1">MTTEEDAMIRLSAQPMTWVAAGDSITQAVLHTHGARGWVEHLQERIRWELDRLTDIVVNSGVSGWRAVDVLGSYDHLIGRFAPDVLSLSLGTNDARAGLAGLPEFRDAMRRIIDRSGAQTQTVLHTPVLVSVAGREARGELPAYAQAVREIAEETGALLVDHEAHWRAHFGDADPISWLDDPAHPNAAGHLQMAEHTLRALGLGPMSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7U2</accession>
    <name>A0A0F4J7U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6649"/>
    <dbReference type="EnsemblBacteria" id="KJY30442">
        <property type="protein sequence ID" value="KJY30442"/>
        <property type="gene ID" value="VR44_20465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8804"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="182"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="26846" checksum="FF2DB52BF1634727" modified="2015-06-24" version="1">MKLFEKLFGKKNREESGSARHRAGHGDGEGQGDRPLFRDEVGGAQGPSAGGPAAAGRIGSGDQAAPNAGGGYAPDPYATSASAGQTCGRCGHRSDAASRFCSNCGAPLRPGLTPERASETTSTISISGLEAYEAEATGQHVSPSLSPEAQAAVEALPPGSALLIVRRGPNSGSRFLLDGELTTAGRHPQSDIFLDDVTVSRLHVEFRRGPEGGFTVADVGSLNGTYVNREPIDSVALHNGDEVQIGKYRLVFYASLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7U4</accession>
    <name>A0A0F4J7U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_20490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949006.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000563.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6654"/>
    <dbReference type="EnsemblBacteria" id="KJY30447">
        <property type="protein sequence ID" value="KJY30447"/>
        <property type="gene ID" value="VR44_20490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8809"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY30447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="22241" checksum="027D1A855CFEA7CC" modified="2015-06-24" version="1">MEVQETRVQTDRIFTIPNILSMARLVGVPLFLWLILTEHDGWALLVLMLSGVSDYLDGKLARRWNQISKLGRLLDPAADRLYVLTTLFGLTYRGILPLWLTAALLAREAMLLVMVWILRRHGYPPPQVNFLGKAATFNLMYAFPLLLLSDGTGWLAWMASVFGWAFAGWGTTLYWWAGILYVVQVRRLVKADATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Y4</accession>
    <name>A0A0F4J8Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000533">
        <property type="protein sequence ID" value="KJY30842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30842">
        <property type="protein sequence ID" value="KJY30842"/>
        <property type="gene ID" value="VR44_19405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8490"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15084" checksum="4BF6331D5D4E27B3" modified="2015-06-24" version="1" fragment="single">VADPAGFGLAVPLDFQRTTDDQRVFYVSPDGAFRIGIKVTPASPGGPLAAMRRSDANGPSNNPGYRANTIVPTTHDGLPAALWEFTWNGFSPAEGARHTYDLCWDENGRMYDVWVSAPVGRLTEARAHFDTALDSFTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J917</accession>
    <name>A0A0F4J917_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">VR44_19830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3113"/>
    <dbReference type="EnsemblBacteria" id="KJY30680">
        <property type="protein sequence ID" value="KJY30680"/>
        <property type="gene ID" value="VR44_19830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8585"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="30431" checksum="71E3F1EF0ED10683" modified="2015-06-24" version="1">MSADPTQVLAFETDCHIFSGCGFPGPGLHSFLFEPLWGEAGITSAYFNKPMLLALLGSVIIVAFFWAAFGRARVVPNKLQMVGEAGYDFVRRGIVYETLGKKEGEKYVPFMVSLFFFVWILNVWSIVPVAQFPVTSIIAYPAVLALIVYFIWMSVTFKRHGFVGGLKNLTGYDKSLGPVLPLVMVIEFFSNVLVRPFTHAVRLFANMFAGHTLLLLFTIASWYLLHGIGIAYAGVSFIMVIVMTAFELFIQAVQAYVFVLLACSFIQGALAEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9P1</accession>
    <name>A0A0F4J9P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_18905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948716.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000518.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31087">
        <property type="protein sequence ID" value="KJY31087"/>
        <property type="gene ID" value="VR44_18905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8321"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="14579" checksum="72FA27FAAD61C78E" modified="2015-06-24" version="1">MLTITKEFHFSASHVLDRLPSWHPCARMHGHNYAVVIELSGRREDLTEAGFVRDYRDLDAFKQWMDETFDHRHLNEALGGGISPSAENLAVWIFDQWTERIPELTAVRISETPKTWAEYRPVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA12</accession>
    <name>A0A0F4JA12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000510">
        <property type="protein sequence ID" value="KJY31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948661.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000510.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4152"/>
    <dbReference type="EnsemblBacteria" id="KJY31207">
        <property type="protein sequence ID" value="KJY31207"/>
        <property type="gene ID" value="VR44_18615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8331"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16814" checksum="0531BF1AF00393A3" modified="2015-06-24" version="1">MDAIDREILRELQRDGRLSNQELAQRVGLTPSPCMRRVRQLEQDGVIQGYRAVIDPEAVGRGFEVLVSVEVRRDREAVEAFEAALQDIPDVIEAYRLFGSPGCLLRIAVGDLRAYERLWIERLTALSGVTEVNSQIIMKRIKEPTGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA96</accession>
    <name>A0A0F4JA96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949243.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29896">
        <property type="protein sequence ID" value="KJY29896"/>
        <property type="gene ID" value="VR44_21750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6538" checksum="40F2006103BA1D04" modified="2015-06-24" version="1">MTNAPTEWRKSSYCGEGEACVYVAAAPGTLVRVADRADPAHLVMATTHAAWADFIGSVKQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAD5</accession>
    <name>A0A0F4JAD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949224.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000605.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29916">
        <property type="protein sequence ID" value="KJY29916"/>
        <property type="gene ID" value="VR44_21655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.209"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="189"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="39684" checksum="DA6B65AE1BC3B97C" modified="2015-06-24" version="1">MTAKPKSRRRTRPVLHALTVLALLAASAYFTYALRVQEQAKAPSVQMVQDKNVTAALKGGDAGGQKWERVQSPNRSVLRDATGQVLATFTDGARTATLTGPSRTFTEPANTTTRVVTENWVRLMPEPWKQGAESAPWFKEWFKKYFGSQEDDIFAFAFQYGDQAPVKKDAQGVPYAGDASFGPLNPTGSEGNDLRLEQSDFYDYLGTPYTFRNGVKKQPQSARYRSMDCSGFVRTVFGYRARYPLMPDDTPGPGLPRTANGIARSSLGTDVIPLKGVGAQFRPASIDLIQPGDLLFFKLDARTKDRLDHTGIYLGTDTDGHQIFISSREEANGPTIGDKGGTSRLDGNGYYAATLRSVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAV3</accession>
    <name>A0A0F4JAV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 9">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_21230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 9"/>
    <dbReference type="EMBL" id="JZWV01000590">
        <property type="protein sequence ID" value="KJY30101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949141.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000590.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5502"/>
    <dbReference type="EnsemblBacteria" id="KJY30101">
        <property type="protein sequence ID" value="KJY30101"/>
        <property type="gene ID" value="VR44_21230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8970"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="11">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="10">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="27947" checksum="10FFBAE0EC2244F1" modified="2015-06-24" version="1">MNASVTDPFAAADAAAARLRELTGVESHDVALVMGSGWAPAAEALGAPEAEFPVTELPGFPPPAVEGHGGKIRSYKIGDKRALLFLGRTHFYEGRGVAAVAHGVRTAVAAGCKTVVLTNGCGGLREGMKPGQPVLISDHLNLTATSPIVGANFVDLTDLYSPRLRAMCKEIDETLEEGVYVQFPGPHYETPAEINMIRVMGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGLSGEPLNHEEVLQAGRDSAARMGTLLTQVLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBL4</accession>
    <name>A0A0F4JBL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31194">
        <property type="protein sequence ID" value="KJY31194"/>
        <property type="gene ID" value="VR44_18665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8342"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14922" checksum="2E0EABC416C5AC4A" modified="2015-06-24" version="1">MTVAPQPTTGRRLLVVERAYRGSVETQFADVLYLARELNRQQDGLDILLRGLAVTFATADDDAPARSLRIGRIDLDTLPDPRASLRTLLAEGAGVWAEEADLTGLGTAPDRLLPGVRRARPDSRPDWSAYQGVHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCW2</accession>
    <name>A0A0F4JCW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000535">
        <property type="protein sequence ID" value="KJY30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948814.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000535.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3236"/>
    <dbReference type="EnsemblBacteria" id="KJY30821">
        <property type="protein sequence ID" value="KJY30821"/>
        <property type="gene ID" value="VR44_19415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8492"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21400" checksum="4E2C146EA8171468" modified="2015-06-24" version="1">MNDKEKDAKEQPLRVGVAVRKRRRALHLTLAAVSARSGLSVPFLSQIENERARPSMRSLERVADALETTAVDLLAASDTARTVDLVRAGDDSGLGPVGGVRPLVRGHHQLHALEFNGDQDAGREYQHRNDELMYVVSGACQVEAEGRAYRLEEGDALFLSGGVRHRWRAVSDDTRLLVVAVGDHIHATSEPPSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEQ5</accession>
    <name>A0A0F4JEQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000425">
        <property type="protein sequence ID" value="KJY32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948223.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000425.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32248">
        <property type="protein sequence ID" value="KJY32248"/>
        <property type="gene ID" value="VR44_16295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7713"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="PTHR11879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="29"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="398" mass="42837" checksum="FEA5B75F4F8D818C" modified="2015-06-24" version="1">MLELLPPPPTDPLWDLTYEFGSDERAERLNLVLGVYRDHTGRTPVMAAVREAEIRLAERSESKEYRGLSGNAAFNRALLTLVLGDTGPQGPAGRAAAVQTVAGSGALRLLADLICRTRPGATVWISDPAYVNHRPILEAAGLEVRTYGWRDAEGRFDAAGVLRDLAAAGRDDVVLLQGCCHNPTGVDPEPEDWEALAALAARDGWVPFVDLAYHGLGDGLEADLRATRLLAERVPEMLIAVSCSKNFGLYSDRTGCAIVLGASERAVRHAETALQNAARTLYSMPPEHGAAVVTAVLEDEGLRALWRAELDAMRGRIEANRTSLAAELAELGWGAQAASLVRQRGMFSMLPLTPEEMLRLRRQYAIYGTTAGRINIAGIESGRIPCLARGVAGVLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JET5</accession>
    <name>A0A0F4JET5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Choline transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_16240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000422">
        <property type="protein sequence ID" value="KJY32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948212.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000422.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32278">
        <property type="protein sequence ID" value="KJY32278"/>
        <property type="gene ID" value="VR44_16240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7671"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="573" mass="60016" checksum="FA03333E3CE9DF15" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFF4</accession>
    <name>A0A0F4JFF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948143.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32488">
        <property type="protein sequence ID" value="KJY32488"/>
        <property type="gene ID" value="VR44_15885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7586"/>
    <dbReference type="eggNOG" id="ENOG50337WN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="43397" checksum="691EBED9772E628D" modified="2015-06-24" version="1">MTGPTDDTPDDAYEPPAGGPALIPGPRAAGDDLDPPGVLPSAPPSHAVLKSLLGAWALAACSAEETQAVEDHLTECAPCAEEALRLRDAVGLLHPEESLDLKPLLRSRVLEDCLGKRPARIPVPVWANPYDTETARLDALLRDFGESEWDTPVRLKWFEEDRRRSHRTTVAGVIGHLLTVDGLVATALGLDDPLGPQAPSGGPTGRTEHYWKSAGSPATRKVREPWREQGHTLVRTVSFAGRGVAELDVDYGAFALPLGDAFLERAFECWVHAWDIAEAVDYPYEPPSGPHMHRMIDLAARLLPGALAGRRRSGLAAPARGLVAAGAPGRTLHLEIEGAGGGGWDIALDSPAAKPSREHTVAEVALDGLEFCQLAAGHISPEEAAVGQTGDREAIRDVLFAAASLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG24</accession>
    <name>A0A0F4JG24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000397">
        <property type="protein sequence ID" value="KJY32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32708">
        <property type="protein sequence ID" value="KJY32708"/>
        <property type="gene ID" value="VR44_15380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="30328" checksum="9CB615081B3B3D82" modified="2015-06-24" version="1">MTPAARTAGKREPSRASTAPSSGPPAARAARAASVHIRPVTGSCSAAARRASSRAPYRPQARDTPAPKRRVGRSALPVRRSSMPSRCARVSEFQLQVVEGSPGRHHAAREEYRPLSAASSCSTAQSPCSRSPSRRVSGVSAVSRRAGSSATGRFSARRARSRVRTGWWASTRPRTLRARSRTCGTQSAHRIRTSWTGGLRHAASADARTRPSGVAQPGLQPVDGHPPEPLEAAHLPVEGDPGLRPVPDEPAGHRRGVPVHQLPGHAPPPGRVLGRAPHMPSPAGIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG48</accession>
    <name>A0A0F4JG48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="12" type="ORF">VR44_14355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33180">
        <property type="protein sequence ID" value="KJY33180"/>
        <property type="gene ID" value="VR44_14355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7220"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="407"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="582" mass="60563" checksum="ED3ED111815BA103" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHH7</accession>
    <name>A0A0F4JHH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33650">
        <property type="protein sequence ID" value="KJY33650"/>
        <property type="gene ID" value="VR44_13545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6970"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470735" evidence="2">
        <location>
            <begin position="23"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="83"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="392"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="517" mass="55944" checksum="8203D98C5A340F6E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI55</accession>
    <name>A0A0F4JI55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000358">
        <property type="protein sequence ID" value="KJY33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947797.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000358.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33438">
        <property type="protein sequence ID" value="KJY33438"/>
        <property type="gene ID" value="VR44_13955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7090"/>
    <dbReference type="eggNOG" id="ENOG50345X6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6516" checksum="32E3EA76250015FE" modified="2015-06-24" version="1">MVLSISGVVLLGIICFLFFKKDGMKLTHAVVSALFGFFLAGSAIAPSITASTASLASLLGGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIQ4</accession>
    <name>A0A0F4JIQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947734.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33653">
        <property type="protein sequence ID" value="KJY33653"/>
        <property type="gene ID" value="VR44_13575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6976"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="31153" checksum="B4640CBDD7124970" modified="2015-06-24" version="1">MPHRRWWSPYLFLAPGLAAVLLFSLWPFVNTVVLSLTDARVLEGGSFVGLANYRRALADPDFWLAAANSVLYLLVVVPCLVVLPLGLAVLVRREVPGIGLFRSAFYTPVIASAVVVGLVWQWLLRSDGAVNAVLVRLRLVTEPVPFLTDSTLLLVSAMIVTVWKGLGYYMVFYLAALGNVPGALYEAAALDGAGPVRRFTSITVPSVKPMMLLVGTLSAISALRVFTEIYVLGGESGGPGGGARTLPFLIRQVGLGFAGETGYASALSLLLFLLTLAFSLLGRRLTKGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ05</accession>
    <name>A0A0F4JJ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_13255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947668.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene706"/>
    <dbReference type="EnsemblBacteria" id="KJY33794">
        <property type="protein sequence ID" value="KJY33794"/>
        <property type="gene ID" value="VR44_13255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6870"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="28673" checksum="3D67A5FDB4C5225F" modified="2015-06-24" version="1">MRWLRRNLVVIAGLGTLAYLILPNVVVTVFSFNNPTGRFNYAWQEFSLDAWKDPCGVADLCGSLALSLQIALWATIGATVLGTAIAFALVRYRFRARGAVNSLIFLPMAMPEIVMAASLLALFLNMGIQLGFWTILIAHVMFCLSFVVAAVKARVLSMDPRLEEAARDLYAGPVQTFLRVTLPIAAPGIAAGALLSFALSFDDFIITNFNSGNTVTFPMFVWGSAQRGTPVQINVIGTAMFVIAVLVVLAGQWAGNRRKKAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJL7</accession>
    <name>A0A0F4JJL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">VR44_14345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947865.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33166">
        <property type="protein sequence ID" value="KJY33166"/>
        <property type="gene ID" value="VR44_14345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7218"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="58"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19212" checksum="BA217BF499FF0EE2" modified="2015-06-24" version="1">MSIESCTPEVRELLLSRITDVPNYPKPGVMFKDITPLLADPKAFGALTDTLVELAGRYGATKIVGLEARGFILAAPVAVKAGIGFIPVRKAGKLPGATLAQAYELEYGTAEIEVHAEDLSAGDRVMVIDDVLATGGTAEASLELIRRAGADVAGVAVLMELSFLPGREKLSGALAGAPLDALIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKS1</accession>
    <name>A0A0F4JKS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34383">
        <property type="protein sequence ID" value="KJY34383"/>
        <property type="gene ID" value="VR44_11970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6479"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="33130" checksum="EFC900967FB48B5F" modified="2015-06-24" version="1">MLSGAFTAFRRYWKPLTGVILLVQGIGILLVGAAIGIAGVGVDTRFAAVFNLPAGETPAAGDVVALLLYLAPVVVLMLVTMVLLTGMIAAVCPAVIQEAVLGRPTTFAAMWRRCWSRLPSVLGVLVCVGLLAGGPVLVLYAVCVPWLFADGGVPPLPVFVLLLGVLLWMPVMLWLAVRFSLAPAVAVCEGLGPIASMRRSARLVGGGWWRTFGIAALGYLMAAVVGYAVQLPFTFLGMFALLPAVLATGEAGDPTTLLSGIAVYVACMMLGMAVGSVFQLGYPQLVLSLLYVDQRIRKENLAEALLTAAAPAPPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKV1</accession>
    <name>A0A0F4JKV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000260">
        <property type="protein sequence ID" value="KJY34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947291.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000260.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34830">
        <property type="protein sequence ID" value="KJY34830"/>
        <property type="gene ID" value="VR44_11235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="30552" checksum="2FAD9D6E6DBDA915" modified="2015-06-24" version="1">MTVETVETAPTCAYPGCTHAPEPKAPGTEGPASRYCDHPDHNALGAFRKFRAKRQQRKEDKRAAADARKAAKEEANGAAEGATAAGQSWPAASAPGAQVVSQAHGHTPATETSEPAPALKAMETTEAMASTAAADCGDGAQSRDTVVALIRQLSTDLPAYIEELAIITDSAAAEARIETVTRASAQRILAAEERATLAEEAADMAVTALDAAIEKFAQETTAIREEAAGKVADAEFVRAELERYRERVGMLEVRLDAVRDEADALRRAQVATPAATSSPATPAEHAHPAGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLK7</accession>
    <name>A0A0F4JLK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">VR44_13100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="JZWV01000333">
        <property type="protein sequence ID" value="KJY33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947639.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000333.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2338"/>
    <dbReference type="EnsemblBacteria" id="KJY33846">
        <property type="protein sequence ID" value="KJY33846"/>
        <property type="gene ID" value="VR44_13100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6681"/>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21315" checksum="80C425A145BC59EA" modified="2015-06-24" version="1">MPTTSATGANNSASAGTGAQESIMLELVDESGNTIGTAEKLSAHQSPGLLHRAFSVFLFDEQGRLLIQQRALGKYHSPGVWSNTCCGHPYPGESPFAAAARRTHEELGLSPSLLAEAGTVRYNHPDPASGLVEQEYNHLFVGLAQASLDPDPEEVGDTAFVTAEELAKRHAKEPFSAWFMTVLDAARPAIRELTGDAAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLQ1</accession>
    <name>A0A0F4JLQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947215.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3387"/>
    <dbReference type="EnsemblBacteria" id="KJY35115">
        <property type="protein sequence ID" value="KJY35115"/>
        <property type="gene ID" value="VR44_10820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6014"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032555">
        <property type="entry name" value="DUF4937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16291">
        <property type="entry name" value="DUF4937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4937" evidence="1">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="22874" checksum="EF5B0D59E6C85048" modified="2015-06-24" version="1">MLVKWIRCTVTDRRGFERGQRKWAGLPGEPGFRGQGGGWSRGRQGVAHVFAFWESRSFYDSFMARSHDRLAAAQTGTYTDARVTLFDYRFDVKTGFEPRFSDADVVRVAHTRVREGRVEHFALMQEKVWNPAMAGSPGMIRGLFGEAPGREFLVLSMWRAAAEHGKYRQERVERLSLRAQTEADVEALTGDVVDLEPSWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN52</accession>
    <name>A0A0F4JN52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="6" type="ORF">VR44_10500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947152.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35259">
        <property type="protein sequence ID" value="KJY35259"/>
        <property type="gene ID" value="VR44_10500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5843"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="11514" checksum="3CA6B7E9E08796D9" modified="2015-06-24" version="1">MAKKSKIAQNEKRKAIVGRYARRRAELKEILRRPSSTDAERAAALAELRKQPRDASATRVRNRDSVDGRPRGHLRRFGLSRVRMREQAHAGLLPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN68</accession>
    <name>A0A0F4JN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947000.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35635">
        <property type="protein sequence ID" value="KJY35635"/>
        <property type="gene ID" value="VR44_09680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5384"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="471" mass="47784" checksum="A4E0381986A39424" modified="2015-06-24" version="1">MPTAPTAEDSPAALGPAPGQLGRILAVVITGAVMSVLDMTIVNVALDRLSESFGSPLETIQWTATAYTLALAAVIPAAAWAMGRIGAKRTYLTALSLFTLGSLLAACAWSAGSLIAFRAVQGLGGGLLMPVGMTMVMRAADRDRLGRAMALLGLPVLVGPVAGPVLGGWLVDTASWQWIFLVNLPVGAAALILAAKLLRPDSPLGAAASPRLDLPGLLSLSPGLALLLYGLSRGGESGRFLSPGVLAPLLGGAVLVAAFVRRALRVPEPLLDLRLLCDRTFAAAIGTLAPFTCGYFGSMLLAPVYWQQARGLSASAAGLLVAPVGLVVGTTMQIASRRVDEVAPRRLVPAGVAVAALGMLLAGLRTGTPGVPGWQVVGSLMVMGIGAGMVLMPTMTTAGRDLPAARMAAASTALSINSQLCASVGTALTSVVLGATGTTPAGFRTAYAVAAGLLALSLLPALRLPGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNH7</accession>
    <name>A0A0F4JNH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947414.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34466">
        <property type="protein sequence ID" value="KJY34466"/>
        <property type="gene ID" value="VR44_11875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6380"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15792" checksum="E0EE6FBAED70CA83" modified="2015-06-24" version="1">MPIKLENVGIAVRDLEAAISFFTDLGLTVLGRGTVSGEWTDTAVGLDGNHAKIAVLQTPDGQGRLELFEYIHPEAIETRPARPHDIGMHRIAFSVDDIDEALATAARHGCHPLRGVATYEDTYKLTYVRGPSGILVMLAQDLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP63</accession>
    <name>A0A0F4JP63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946999.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35634">
        <property type="protein sequence ID" value="KJY35634"/>
        <property type="gene ID" value="VR44_09670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5382"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14700" checksum="F864785780AA9999" modified="2015-06-24" version="1">MTIVLNDTVRQLLDSPHPAVLSTLNPDGSPQSSVVWVIREGDDLLVSTERGRRKERNLVRDGRVGLTVFDLANPYLYAEIRGTATISEDTGRAVAVRIAEQYLGPGAGKEYGDASDGAVRVVVRITPSKVLGNAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP92</accession>
    <name>A0A0F4JP92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35664">
        <property type="protein sequence ID" value="KJY35664"/>
        <property type="gene ID" value="VR44_09545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5310"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="301" mass="31770" checksum="D57926E41526D94A" modified="2015-06-24" version="1">MRSVVLDADGIPLSGLLALPADPVPRAVVVALHGAGMSAGYFDSRVRPGFSLLELGASLGFAVLALDRPGYGASAAPLPGGLPLAGQTDALLAALDGYARGHELGAGFFLVAHSNGGRLALSAAAAARGRAAPLGVDLCGVGRHFAVEPGQLPGTDFAGQWRRHWGALRFYPPEAFRACSGLVRPVPAEEARETPLWPGMYPAVAAGVRAPVRFTFAEQELWWRQDSAAMEELLSPLMGASTEVVIQPHAGHNTSLGWAARAYHLRVMAFLEQCLLARDPGGERVPVTTDREMNKVDRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQS7</accession>
    <name>A0A0F4JQS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000144">
        <property type="protein sequence ID" value="KJY36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2235"/>
    <dbReference type="EnsemblBacteria" id="KJY36717">
        <property type="protein sequence ID" value="KJY36717"/>
        <property type="gene ID" value="VR44_07340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3939"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="695" mass="75234" checksum="6B15EDEB28E4F8DF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQV0</accession>
    <name>A0A0F4JQV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Virulence factor MVIN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_07285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000142">
        <property type="protein sequence ID" value="KJY36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36742">
        <property type="protein sequence ID" value="KJY36742"/>
        <property type="gene ID" value="VR44_07285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3928"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="491" mass="51245" checksum="87044D3947803038" modified="2015-06-24" version="1">MASTLLIEDAMALLMVPAFSHALARRAASRAGLTRKEARAADPVRLLVGATLPRLMVFLAAVASVLVVAAPLVVGVLAPGLPDPELAVQCTRMTALTVLTFGIAGYFSAALRAHRSFLPPAAIYVSYNVGIIGTMVALHTLWGVRAAAAGVAVGGLLMVLVQLPAFIRNVGFGPPRAKRAAPRSQRDRDRPTLIAFGVIAPVISFAVFRQSQVLVERFLAASLPPGAISHLNYAQKVAQMPMVLSLMICTVTFPVVAQAMAGGEREKARRRVEQDLALASLAVLLGMALVIGYAPQIIEVLFERGAFTHQDTLTTASVMRVYGLGLLGHCLVGALSRPFFSTARPTWFPALAMGAGLLVNIAAGALFVGWWGTYGIAAANAAGITAAAALLLTGIGSRIIAIQARRVAVSIGRLAVAAASACATGWLAGPMIPDPLLSAALGCLLVPAMFGATGMAMRALEITALPGQIAQLAAQTVTRITQLTQRFRNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQZ9</accession>
    <name>A0A0F4JQZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000148">
        <property type="protein sequence ID" value="KJY36605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946616.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000148.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene559"/>
    <dbReference type="EnsemblBacteria" id="KJY36605">
        <property type="protein sequence ID" value="KJY36605"/>
        <property type="gene ID" value="VR44_07610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4000"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="31002" checksum="60C2EC4519D9E148" modified="2015-06-24" version="1">MSPSPSSSAAKDAPPPLPEPLRVAVADSHTHLDMQAGSVEEGLAKAASVGVTTVVQVGCDVKGSRWAAETAAAHPNVHAAVALHPNEAPRIVLGDPDGWSRQGARAGGGEGALDDALAEIEALAALGHVKAVGETGLDYFRTGPEGMAAQERSFRAHIEIAKRQGKALVIHDRDAHADVLRVLREEGAPERTVFHCYSGDAEMARECAAAGYYMSFAGTVTFKNAAPLREALAVAPLELVLVETDAPYLTPAPYRGRPNAPYLIPLTVRAMAAVRGIDEDAMATALAANTARAFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS35</accession>
    <name>A0A0F4JS35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_07740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000150">
        <property type="protein sequence ID" value="KJY36568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946641.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000150.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36568">
        <property type="protein sequence ID" value="KJY36568"/>
        <property type="gene ID" value="VR44_07740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4251"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="34231" checksum="3F5383CDE7DA91EF" modified="2015-06-24" version="1" fragment="single">GEAYTVRVGAQDGDGTPVGVTLAFRTARPAVEGGRLTAEFGPRPGTYGAGQIVTAELSRPVPADAPEVRARVEQALQVTSEPHVEGAWHWVDDATLHFRPRTYWPAHTVVRVRSGLDGLELGDLGYGGPSEPLEFTVADRIEAVTDSAAHEMTVRRNGRVIRTIPVTTGKAGFLTRSGIKVVLGKEAKVRMRGDTVGIQKGTKEFYDLPVLYATRVTWSGEYVHAAPWSVAAQGEENVSHGCTGMSTEDAAWFYETVREGDIVEVVNSGGDRMSPFDNGFGDWNVDWRTWLAGSALTPAAAQPAPRTDTAASRLDPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSZ6</accession>
    <name>A0A0F4JSZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000179">
        <property type="protein sequence ID" value="KJY36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36081">
        <property type="protein sequence ID" value="KJY36081"/>
        <property type="gene ID" value="VR44_08640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4870"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470838" evidence="1">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="20977" checksum="FA1373702D98BF84" modified="2015-06-24" version="1" fragment="single">MAPRTGRIAPLALAAAATLAAAPSAPAAAPPKPRLTPAAQLALAYRATAKYHQHSTGVAAGYVPDQYCVVDPNGGPGALGYPHFNHAYDGSVDPAKPTALLYEGDGQGHWNLVGLEWMVVDKDGRTDTDDARPSLFGEPFKGPLPARYKGQKVHYSLHLWLWKDNPSGRFEPFNPRVVCRPGTTRPRPVAPATPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT40</accession>
    <name>A0A0F4JT40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000108">
        <property type="protein sequence ID" value="KJY37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946290.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000108.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37355">
        <property type="protein sequence ID" value="KJY37355"/>
        <property type="gene ID" value="VR44_05860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1988"/>
    <dbReference type="eggNOG" id="ENOG5033F74">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="8953" checksum="C1C0B2AD7A0BDA65" modified="2015-06-24" version="1">MNLRHVLVLPDRDAAEEVAQEAVDRFGLPEEPQLVRDALAGEDDAEDAQWLVVVEDPQQRLDTAVLDELAAEYEGWLEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTZ3</accession>
    <name>A0A0F4JTZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VR44_05935</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946305.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37309">
        <property type="protein sequence ID" value="KJY37309"/>
        <property type="gene ID" value="VR44_05935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2401"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJY37309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="29991" checksum="81FD7ED289EF215F" modified="2015-06-24" version="1">MPEGHTIHRLAQDHTERFAARPVRVSSPQGRFAESAALLDGRELESAEAHGKHLFLELGDAWIHIHLGLFGKLGFGPAPAPPATDTVRLRLLNDDHYADLRGPTACALVTGAEKKAIHDRLGPDPLRPADDPARAWSRISRSRTTIAALLMDQKVIAGVGNVYRAEVLFRHGIDPYRQGRDLTRTEWDAMWADLAELMREGVRRNRIDTVRDEHLPEAMGRPPRVDDHGGEVYVYRRATLPCHICGSEIRTADLAARNLFWCPTCQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU86</accession>
    <name>A0A0F4JU86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">VR44_06010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946319.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2628"/>
    <dbReference type="EnsemblBacteria" id="KJY37323">
        <property type="protein sequence ID" value="KJY37323"/>
        <property type="gene ID" value="VR44_06010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2416"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY37323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="36125" checksum="2F3098F15642C41B" modified="2015-06-24" version="1">MRVGIVGATGQVGGVMRSILAERKFPVDELRLFASARSAGSTLEWQGQEITIEDAATADYSGLDIVLFSAGGATSKALAEKVASQGAVVIDNSSAWRGHPEVPLVVSEVNPHAIKNRPKGIIANPNCTTMAAMPVLRPLHDEAGLTALIATTYQAVSGSGLAGVAELKGQACAVSEAADQLTFDGDAVEFPEPAVYKRPIAYNVVPLAGNLVDDGSFETDEEQKLRNESRKILEIPGLKVSGTCVRVPVFSGHSLQVNARFERPISVERAYELLKDAPGVELSEIPTPLQAAGKDASYVGRIRVDETVDNGLALFLSNDNLRKGAALNAVQIAELVADELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUP7</accession>
    <name>A0A0F4JUP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000101">
        <property type="protein sequence ID" value="KJY37544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946226.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37544">
        <property type="protein sequence ID" value="KJY37544"/>
        <property type="gene ID" value="VR44_05510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1739"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07576">
        <property type="entry name" value="R-amidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044083">
        <property type="entry name" value="RamA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="28663" checksum="47CC975FD7418B6E" modified="2015-06-24" version="1">MPPLRTALLQSSGRLGDTAENLKRLDEAAARAAQSGGGLLVTSEMYLTGYALEVGDIAGLAEPADGESAHTIGGIARRHGIAVLYGYPERDGDTVYNSAQLIGPDGARLANYRKTHLFGCFEQEAFTPGDTPVVQADLNGLRVGIMICYDVEFPENVRAHALAGTDLLLVPTAQMHPFQFVAEQLVPVRAFENQMYIAYVNRTGPEGEFEFVGLSCLASPDGVTRTRAGRGEEMVFGEVDPELLGASRETNPYLRDRRPGLYASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV53</accession>
    <name>A0A0F4JV53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945947.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38242">
        <property type="protein sequence ID" value="KJY38242"/>
        <property type="gene ID" value="VR44_03995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8704"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="25978" checksum="2DFAF438EAEF865A" modified="2015-06-24" version="1">MGGTQAIRASGRDGRGGLGNTLSGIAVAIGFALFLGGFVWGALVYRPYTVPTNSMVPTVQPGDRVLAERIGGAEVRRGDVVVFKDSQWSDSPMVKRVVAVGGDTVSCCGQGGGLTVNGKPLDEPYVDQAGRDALAAGTTTFEVTVPEGNLFLMGDRRSGSLDSRAHLQDAGQGTVPRSAVEARVDALAWPNTRMLDRPQAFAALPGGVSQPGPLRLQVAAVVAGAALVVLGAAYGPVARVLGRGRARGRSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVC6</accession>
    <name>A0A0F4JVC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_04195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945987.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38105">
        <property type="protein sequence ID" value="KJY38105"/>
        <property type="gene ID" value="VR44_04195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.128"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="49008" checksum="AC388D702D3538F6" modified="2015-06-24" version="1">MPSTTEPYDFIGIGLGPFNLGLACLTAPIDELDGLFIESKPHFEWHAGMFLDGAHLQTPFMSDLVTLADPTSPFSFLNYLKDKDRLYSFYIRENFYPLRAEYNDYCRWAADRLDNIRYSTSVTEVSYDGSAGLYEVHTDRGETFLTRRLVLGTGTPPHIPASCEDLGGDFLHNSAYMEHKEALQKKKSITLIGSGQSAAEIYYDLLTEIDVHGYRLDWVTRSPRFFPLEYTKLTLEMTSPEYVDYFHALPEDTRYRLESRQKNLFKGIDGDLINAIFDLLYQKKITMPGPVPTTLLTNTSLNSTAYDTTTGTYTLGLRQEEQERDFSLTTEGLVLATGYKYRVPEFLAPVRDRLNFDGHGRLDAGRNYAVDVTGRGVYLQNGTTHNHSLTSPDLGMAAYRNAYIVGELLGREYYKVEKSIAFQQFAAPEGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVW3</accession>
    <name>A0A0F4JVW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37111">
        <property type="protein sequence ID" value="KJY37111"/>
        <property type="gene ID" value="VR44_06455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471407" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17140" checksum="4EF2470D39F9E88E" modified="2015-06-24" version="1" fragment="single">MHRRKVLTLGLGVGIAAALPGTASASAVDPKELVERSLFHLPEARPASRDALFSALVEARRVFQAAEYSKLGRTLPSLISGSLASQAHDIAARAYVLLAQLAIKNYQGMAWVAAERARAQAELTGNPVVMGEAAHSMGVSLRRSGEYQAAIDHLQEAAGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWI4</accession>
    <name>A0A0F4JWI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_02955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945762.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4900"/>
    <dbReference type="EnsemblBacteria" id="KJY38732">
        <property type="protein sequence ID" value="KJY38732"/>
        <property type="gene ID" value="VR44_02955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7323"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="176"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="43303" checksum="E25875E8CE6F2840" modified="2015-06-24" version="1">MPQPEREHSPEIRPAHPAHPHAATLRRLEKSSGRLAANAIARMDESLPWYRAMPPENRSWIGLVAQAGIAAFTEWFRHPETPQAISTDVFGTAPRELTRAITLRQTVEMVRTTIEVMEAAIDEVAAPGDESILREALLVYAREIAFATAQVYAQAAEARGAWDARLESLVVNAVLSGEADEGALSRAAALGWNSPEHVCVVLGTAPEGDSELTVEAIRRAARHHKLQVLTGVLGARLVVIAGGSDNPLQVAKSLIGPFAAGPVVAGPVVPDLLNATKSAQAAAAGLKACTAWQDAPRPVLADDLLPERAIASDPSAREQLVEEIYRPLEEAGSALLETLSVYLEQASSLEGAARMLFVHPNTVRYRLRRVTDVTGWSPSDVRSAFTLRIALILGRLADGDQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWK0</accession>
    <name>A0A0F4JWK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_03885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945931.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38224">
        <property type="protein sequence ID" value="KJY38224"/>
        <property type="gene ID" value="VR44_03885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8681"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="50298" checksum="C9B886FC2796FE0F" modified="2015-06-24" version="1">MTSSTAKPASSGANAPHPDHLGHVIFIAAAAAMGGFLFGYDSSVINGAVVAIRERFDVGPAVLAQVIAAALIGCAVGAATAGRLADRLGRIRCMQIAAVLFTASAIGSALPFALWDLAVWRVIGGFGIGMASVIGPAYIAEVSPAAYRGRLASFQQAAIVIGIAVSQLVNWGILNLADGDQRGVIGGLEAWQWMLGVMVVPAVLYGLMSFVIPESPRFLVSVGRNAEARKVLAEVEGSHVDLDARVAEIETAMRSEHKSTFKDLLGGRFGLLPIVWVGIGLSVFQQLVGINVIFYYSSSLWQSVGIDPTSSFLYSFTTSIINIVGTVIAMIFVDRIGRKPLALIGSAGMAISLGLCAWAFSYKTEVAGEISMPSTQGTVALVAAHAFVLFFALSWGVVVWVLLGEMFPNRIRAAALGVAAAAQWVANWLITVTFPTLSDWNLSGAYVIYTVFAVLSIPFILKWVPETKGKALEEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWN1</accession>
    <name>A0A0F4JWN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945850.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38540">
        <property type="protein sequence ID" value="KJY38540"/>
        <property type="gene ID" value="VR44_03410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7899"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15080" checksum="66E12A19873EF6B0" modified="2015-06-24" version="1">MATVELRFSAQPEHVRTARLVAAAVARRAGVEEAVLDEVRLAVGEACSRAVGLHRSNGLTAPVRVVLIEEEKVFSIEVGDEVPGPAGGSSEPVPAMDAALDPDADGEDEMGLAVISGLVDDVSVTSGESGGTIRMRWPVAGVPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWU6</accession>
    <name>A0A0F4JWU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945813.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38610">
        <property type="protein sequence ID" value="KJY38610"/>
        <property type="gene ID" value="VR44_03205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7856"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="36909" checksum="0D5C41CDE0454736" modified="2015-06-24" version="1">MRDDHKNPPGPAAPAIADEQVLRSLFAGAVQGLEPSEGALERLRHAVPARRARKRQTLVGAAVAVLLAGTGIPAAMHLGDEDEGGTAAGHSAMAGHGEAQGAVPGDPHHDGPAGGTRPQPARPPGKGQTAGGAGDRPSPQPGGSPSGGVSAGPSGSGAPTAALGNGPQPPAGAAAAAPGCTGDQLGVAGSARAPEADGKVYGSFKVTNVSARGCVVTGPDTVTAASVPQGPPPAQPRGVTVTGHTAGDPASGLPDPSAEAPVLVLQPKQTYEVLFAWVPSSQSCPAATPGPTATPQQQDSVRQRPAGQSDGGPANTSAGGAAGAPAGAGDTAGGVQRPADPDPAGVAVSHTPATAPGAPVTQTTIPQACGGTVYRTGLIPQPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXH6</accession>
    <name>A0A0F4JXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945883.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38433">
        <property type="protein sequence ID" value="KJY38433"/>
        <property type="gene ID" value="VR44_03605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8259"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470972" evidence="2">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="43041" checksum="851335DA4CDEB8EC" modified="2015-06-24" version="1">MRALAGWAVRAAAAVLTAAALGHTLWTGVTEPGTALAFAALITLGELARRDHPAQDRRPAPLGSAGALAYALLGQDAGLPTHHGVLQIVAVVVAAALAGIVPHIARGHAPALDHVARRVLAVAFAAACFQPLYGSGRLTHRIGQGPFLVLFLLLLLGLTALCDAVLAAALAGARTGWPFGPLLRDELRAQLGIGSAICATGVVMALGVAVAGLWALPVFSVPLLLTQLSFHRVDAVRTTYRQTITSLARATEIAGCTAPGHSRRVAALSCAVGRELGLSERELTVLEYAALMHDIGQLSLVDPVPGGATAELPPDEARRIAGLGGEVARQTGVPAEVAVIVERQADPYREQPVAARIVRAVNAYDDLAGAGGHPGGPLAALERLRLGTGHDYQPEVVESLARVLARGGRGRVVPAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYT8</accession>
    <name>A0A0F4JYT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000043">
        <property type="protein sequence ID" value="KJY38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38913">
        <property type="protein sequence ID" value="KJY38913"/>
        <property type="gene ID" value="VR44_02685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6843"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11644" checksum="790ABBB6597C4DF5" modified="2015-06-24" version="1" fragment="single">ISQAGGTPLLVAVEDADGARVLGVIHLKDVVKEGMRERFDELRRMGIKTVMITGDNPLTAKAIAEEAGVDDFLAEATPEDKMALIKREQAGGKLVAMTGDGTNDAPALAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYZ1</accession>
    <name>A0A0F4JYZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_03895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945933.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38226">
        <property type="protein sequence ID" value="KJY38226"/>
        <property type="gene ID" value="VR44_03895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8683"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="481" mass="50243" checksum="39100D8CDDFD6663" modified="2015-06-24" version="1">MPAEETAVETRGLEPVPDGERGGRVRELIPTWVAANISVLLLTMGAGLVIFNKLNIWQVLVVAVAAPAVSYGLVGLISIAGKRGGAPGMALSRAVFGQRGNLFPGALIWVARWGWETINAVSGAYAVLTVLDLLFGIKSNTALIVVTLLFFVGCTFVVSGLGIKALRVCSTWSTYLFGAFSVLVLGYLLFTTDWSAVLGKPAGSTAMMVAGIGTIAAGGISWVPSGPDFTRYLPRTASAKGVVGATIGGAGVVVLPMVLMGAVMAVGTPDLAGTQDPVSFIGELLPTWIAVPYLLIALLGMLLINSMSMYSAGFTAQTLGIRVPRAWAVSVNAVISLVFGFLLMVVATSFFGSFISFLTLLAVAFSAWIGVFGVDMLRRTSYDGPALLDTTRTSAYWYRGGFAWQAMTAWGLALVVGTLFTKVDWFTGPLATTWIGENGLGWVAGILTSGALYAVLPRTASPAPAEPEPAAGREPAGTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYZ5</accession>
    <name>A0A0F4JYZ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="12" type="ORF">VR44_03930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945938.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene758"/>
    <dbReference type="EnsemblBacteria" id="KJY38231">
        <property type="protein sequence ID" value="KJY38231"/>
        <property type="gene ID" value="VR44_03930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8691"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="99"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="100"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY38231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="524" mass="55976" checksum="8646C4631835EB14" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ03</accession>
    <name>A0A0F4JZ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945401.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39622">
        <property type="protein sequence ID" value="KJY39622"/>
        <property type="gene ID" value="VR44_01010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2915"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16913" checksum="4CA12A8F3D1BA307" modified="2015-06-24" version="1">MNEPSGLTIRPATEADLPAIVAMLADDPLGATRESPDDLAPYARALKRLTEDPHQHVVVAVRGERVVGTLQLTFVPGLSRRGSTRSIIEGVRIHADERGSGLGTRFIEWAVDRSREENCQLVQLTSDVSRTDAHRFYERLGFTPSHVGFKLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZA1</accession>
    <name>A0A0F4JZA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945325.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39737">
        <property type="protein sequence ID" value="KJY39737"/>
        <property type="gene ID" value="VR44_00575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2821"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="19822" checksum="91C1060BB00D5C01" modified="2015-06-24" version="1">MSEERRILLADAAIEVLAELGMRGLTHRAVDRAGGLPPGTTSAYLRTRAALLTALVRRLVDRDQAELQAAGEHTALPLTPAELTDGLVALTTARLTGEGRMRSLARYACVLESVRDPELREILVPRENAGRDVVRAFLAAHGVPDPESRTLSLLACVDGLVLEHLPTGATGVPREALEGLVAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZY1</accession>
    <name>A0A0F4JZY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945364.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4785"/>
    <dbReference type="EnsemblBacteria" id="KJY39710">
        <property type="protein sequence ID" value="KJY39710"/>
        <property type="gene ID" value="VR44_00795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2864"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="19169" checksum="9E5EB6C7307F25BA" modified="2015-06-24" version="1">MDAVQQEATARARELQRSWYGEPLGALFRRLIDDLGLNQARLAAVLGLSAPMLSQLMSGQRAKIGNPAVVQRVQALQDLAGQVADGSVSAAEATDRMDQIKNTQGGSVLSNSGQTTPGSGAPTVKRVVREIQSLLRSVSAAGDIIDAANALAPSHPELAEFLRVYGAGRTAEAVAHYEAHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K015</accession>
    <name>A0A0F4K015_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_00430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39962">
        <property type="protein sequence ID" value="KJY39962"/>
        <property type="gene ID" value="VR44_00430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.84"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY39962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="424" mass="45278" checksum="2E4D17D04C6194C3" modified="2015-06-24" version="1">MRIWLTGSGRPVTGDRLVSWLLRPAPRSWRVVALVALVTVSVSTSLRANWGSDNAFVVKAADALLEGVSPYEDKRFLYLPSAVLVAVPEALVPTGLLRWLLPAGISGLVALGWWASLRLFSVPVRSRFAVAGLGLLGTVYKPYLNLVLIGNWTAVSAAALPVALLLAHRRSWVAAGLVVGLAIACRPMLVPAGLLFVLARRWRGLAVAVAVPAGLSLAGALLMPSPTLFFTKTLPFLFQGQDAYALPWDASPIAVLPRLGVPQAVAVTVAFAGAGAVLWGAWRRWHRPDSAEVDGGELRLAETACMVMLAAFLVSRPSFDHYLLVVLPLLLASGVRPGSMPRSPWFWLALTPQLALVPWPSELAHKRRAFKDAATLCGLAYLLGRRALPSGRVILIPVTTAGSPPRTEPECAATPAESASRTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Q6</accession>
    <name>A0A0F4K0Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945498.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39508">
        <property type="protein sequence ID" value="KJY39508"/>
        <property type="gene ID" value="VR44_01535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4740"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="35369" checksum="F545E398735B01C2" modified="2015-06-24" version="1">MTAPTTVRTVDYHTAGEPFRIVAEGLPPVPGDTVAERCATAIGPGGSGTAPRRGPLDEVRRLLVQEPRGHAGMYGGFVVPPDDDGAHFGVLFWHKDGYSTACGHGTMALGAWAVDSGRVAAPDEGDVQVRIDVPSGRVAATVHRAQGRTTGVTFRNVPARVGARKVPVATTLGIAEVDIAHAGACYASVRARDLGLEVTRAALPELVRAGREIRAALATHPATWHPDGPLLSGVYGVVLHEELPDTPFGPHQRNVTVFADGQIDRSPCGSGTSARLALLAEDGRLGPGEDLLHESVTGTVFTGRIFADGVTEVTGTAYRTGDHAFTADPYDALGAGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1E1</accession>
    <name>A0A0F4K1E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_00610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945336.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39748">
        <property type="protein sequence ID" value="KJY39748"/>
        <property type="gene ID" value="VR44_00610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2828"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041040">
        <property type="entry name" value="3HCDH_RFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18321">
        <property type="entry name" value="3HCDH_RFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_RFF" evidence="5">
        <location>
            <begin position="349"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="413"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="514" mass="53701" checksum="3EDA3B7143C10042" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2T8</accession>
    <name>A0A0F4K2T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945481.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39491">
        <property type="protein sequence ID" value="KJY39491"/>
        <property type="gene ID" value="VR44_01425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4717"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="189"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="463"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="792"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="850" mass="93486" checksum="9E886F825E55427A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2V6</accession>
    <name>A0A0F4K2V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_01580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39516">
        <property type="protein sequence ID" value="KJY39516"/>
        <property type="gene ID" value="VR44_01580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4749"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="2"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="499" mass="52390" checksum="2D48ACB7705C48C7" modified="2015-06-24" version="1">MALFVIASCQLMVVLDITIVNIALPHIQTALDFSTESLSWVVNAYTLTFGGLLLLGGRTGDILGRKRVFISGVLLFGLASLLGGLAQNEGQLMAARALQGVGGAIASPTALALITTTFREGPARNRAFGVFAAVSAGGGAIGLLAGGLLVEWLNWRWVFFVNVPIAVVIAVMARRVLRESARHAGHFDLAGALLGTCGMVALVYGFIRASQHGWADGFTLGSFAAAVVLLTLFVVNERRSPQPITPLHMFADRNRAGTYGIMLFLACAIFGMFFFLTLFVQNVLGFSPLRAGLAFLPVSVMVAVSATVTSRLLPRFGPKPFMVGGALCCAAGLAWMTRIDVDSTYPGSILGPLLVFATGMGMQFVSLTLTALSDVPDRESGAASGLLNSMQQVGGSLGLSILVTVFGTASRNEAKAQAVAFVRGSTPEQKAFFARTHQYPKPWSDLVLTAGVSTAFVVASAFTLMGALIAVFAIQVRPSDLERLQGNHTPAGIQGESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3F7</accession>
    <name>A0A0F4K3F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_00635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945370.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39716">
        <property type="protein sequence ID" value="KJY39716"/>
        <property type="gene ID" value="VR44_00635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2833"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="30"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="42035" checksum="8E06165A028BEFA6" modified="2015-06-24" version="1" fragment="single">MERGEDRHPDVLPGAAVVDGLRRALARVSGEALGPYQSAVVRIGFAGTWLFFLLREFPHRHELYGPDGPWSRELAERLVAGNHAFTVLLWSGSGWWFELVYGLAVAASALLALGWRTRATSVLFMVGVLSLQNRSVFMGDGGDNVVHLMAMYLVLTRCARVWSLDARRARERGTASAGAAGPVLWGVLGAVLAYGAVSGRLSDGWTAVFAALWTGAALWWLVERYEPEGERRAALDVFANLLHNAGMLVIMAEVCLIYATAGWYKIQGSRWQDGTALYYPLRLDYFSPWPGLSGVLAGSGVVVMLLTYGTVAVQVAFPFTLFNRRVKNVLLAVMMLEHAGIAVLLGLPFFSLAMIAADAVFLPTGLLVWVGVRVAALRGSLRGASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2X5</accession>
    <name>A0A0F4I2X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001842">
        <property type="protein sequence ID" value="KJY15823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15823">
        <property type="protein sequence ID" value="KJY15823"/>
        <property type="gene ID" value="VR44_40775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="7435" checksum="7E156430C9E93442" modified="2015-06-24" version="1" fragment="single">VGPDEEVAAELERSADRALARGGRAAAAAFLERAAALTPDPKQRARRALAAAAAHLAAAVPARVPDLLAAAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I518</accession>
    <name>A0A0F4I518_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001699">
        <property type="protein sequence ID" value="KJY17017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17017">
        <property type="protein sequence ID" value="KJY17017"/>
        <property type="gene ID" value="VR44_40190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="15694" checksum="62BF9BC2814C1644" modified="2015-06-24" version="1" fragment="single">MELARVPVATAARTAVPVPEATSSVRPPTAAAVGRLTEAAAAAGPGAGADGSVRAPARVDAVEPEPPTAPAPRTDPHPLTPRTEPPEHTPRTDPRDHAPQVEPQPPAARAEFHPPAARTEPRPEGARAERQATTAPAGTAPQGHAPRAERQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IA78</accession>
    <name>A0A0F4IA78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_39920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001661">
        <property type="protein sequence ID" value="KJY17581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17581">
        <property type="protein sequence ID" value="KJY17581"/>
        <property type="gene ID" value="VR44_39920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6322"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="4">
        <location>
            <begin position="253"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY17581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="45769" checksum="8693DA6F2B3D4139" modified="2015-06-24" version="1" fragment="single">RQALADARLTTADVDAVEAHGTGTTLGDPIEAHALLATYGQDRPASRPLLLGALKSNIGHTQAAAGVAGVIKMVMAMRHGILPATLHLDEPSPHVDWSAGAVRLLTEAVAWPETEGPRRAGVSSFGVSGTNAHVVLEQPEPEPAAPASAAPEADAPARAGRSPLVWPLSARTPEALPEQARRLLAYVQENPDTDPADIGHALATTRAQLPYRAAVVGRDRDELLASLTAFARQEPTGHAFEGTAARKTRTAFLFSGQGSQRLGMGRELHTSFPVFAEAFDAVCAALDPHLEQPLREVVFGEDADLLNRTAFTQPALFAVEVASWGVRPDFLAGHSIGEYAAAHVAGVLSLTDAAKLVAARGRLMQALPGGGVMVAVEASEEEVRTLLAGSEDRADIAAVNGPASVVLSGAEDTVTELAAKLAAEGRRTKPLTVSHAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB00</accession>
    <name>A0A0F4IB00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001596">
        <property type="protein sequence ID" value="KJY18653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18653">
        <property type="protein sequence ID" value="KJY18653"/>
        <property type="gene ID" value="VR44_39500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="5157" checksum="EBD4448E4A30E9DD" modified="2015-06-24" version="1" fragment="single">MRSSGNGNGGNRNSGGGGGGRGGARGGSSGGGGYRGGSGSGGGYRGGSGSGGGYRGSSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IEQ9</accession>
    <name>A0A0F4IEQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dethiobiotin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001564">
        <property type="protein sequence ID" value="KJY19151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952466.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001564.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19151">
        <property type="protein sequence ID" value="KJY19151"/>
        <property type="gene ID" value="VR44_39210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY19151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="19551" checksum="AB92E627A4600FFF" modified="2015-06-24" version="1" fragment="single">MSVIVVSGTGTEIGKTVVTSAIAAAAVAAGRSVAVLKPAQTGVGPQEPGDAAEAVRLAGPAVTALELARYPEPLAPDTAARRSGLAAVAPERIAEAADGLARSHDLVLVEGAGGLLVRFDEEGHTLADAARLLAAPVLVVAPAGLGTLNSAALTAEALTARGLRGLGVVVGSWPASPDLASRCNLADLPKVSALPLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IG41</accession>
    <name>A0A0F4IG41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_39050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001545">
        <property type="protein sequence ID" value="KJY19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19631">
        <property type="protein sequence ID" value="KJY19631"/>
        <property type="gene ID" value="VR44_39050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="208"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="35158" checksum="526DA0C8BC4F8CEB" modified="2015-06-24" version="1" fragment="single">MGIGITQEQRELAGAVRGWVARAVPPEAVRKLLDAPPQAGARPGYWDGMCAQGLVTPHLEGGTLLDLAVVVEETARAALPGAFLPSALASVLLDRAGARPLDGRVGAVALGPGGITAVAAEGGGWRLDGVAPPVLGAGEAELVLLAAEGEGGVRWFAVDAADLEVRPHESADPTRPTAEVRAHALTVPAGRLLELDEDLVRDLACVLFAADACGTAAWAVHTAAEHAKVREQFGRPIGQFQGVKHLCADMLVRLEQARALTWDAAGSADEEPAVRSLVAALAAATALDASYSCAKDCIQILGGIGFTWEHDAHIHLRRALVARQLLGPGDAHRLRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IMA8</accession>
    <name>A0A0F4IMA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_37675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001399">
        <property type="protein sequence ID" value="KJY23165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952178.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001399.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23165">
        <property type="protein sequence ID" value="KJY23165"/>
        <property type="gene ID" value="VR44_37675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5040"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="3">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="31155" checksum="F47E229E618E3054" modified="2015-06-24" version="1" fragment="single">FYDARGSELFEEITRLPEYYPTRAEREILLGRAREIAAVTGARTLVELGSGSSEKTRHLIEALPALETYVPVDVSESALTGAAESLLAAHPGLKVHALLADFTAPLHLPDSPGPRLVVFLGGTIGNLRPAERAVFLASVRAMLSPGDALLMGTDLVKDEAVLVAAYDDAQGVTAEFDKNVLAVIDRELGADFHTADFDHVAVWNREHEWIEMRLRARSAVTVKIRALDLVVPFAEGEEILTEISAKFRQERVRRELAEAGLELSQWWTDSEGRFALSLSVADGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPL9</accession>
    <name>A0A0F4IPL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001415">
        <property type="protein sequence ID" value="KJY22586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952214.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001415.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2357"/>
    <dbReference type="EnsemblBacteria" id="KJY22586">
        <property type="protein sequence ID" value="KJY22586"/>
        <property type="gene ID" value="VR44_37860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5131"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="28506" checksum="652FC279FCFD83E5" modified="2015-06-24" version="1">MAATKTTLKTIGSYAAIGDSFTEGVGDPGPGDSYLGWADRLAVLLADQRDEHDFRYANLAVRGKVLDQIVEEQVPRAKELAPDFVSFCAGGNDIIRPGSDPDDVAERFEAAVADLTGAVGLVMITTGFDTRGVPVLKHLRGKIATYNVHVRAIADRYGCPVLDLWSLKTVQDRRAWDGDRLHLSPEGHTRVALRAAQVLGYEVPADPDQPWPPAAPRGSVDVTRDNIQWAREHLVPWIGRRLRGESSGDNVEAKRPDLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK8</accession>
    <name>A0A0F4IRK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001192">
        <property type="protein sequence ID" value="KJY24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24627">
        <property type="protein sequence ID" value="KJY24627"/>
        <property type="gene ID" value="VR44_34785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="23219" checksum="E144F415CD26C63E" modified="2015-06-24" version="1" fragment="single">MERLLDGDPRSVGPYRVLARWPSPGAARSGPEPKAEQGPAVRGRPPRPATSPAMYLGRDRAHVHALICMLPRAACAAAELLAGVSVPGVPEVLELHTADEPPWASLAYTPAVTLAAVAGSTTGTLEPQPADRIRALGGALCETLAGLHQHGVSYGVLIPSGVWLTTGRPLLMALSSCRTSPTAERGRHGEEIVPPSVLPAPFMAPETVGGRVSSQAADIYALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRX6</accession>
    <name>A0A0F4IRX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001173">
        <property type="protein sequence ID" value="KJY24752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951571.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene42"/>
    <dbReference type="EnsemblBacteria" id="KJY24752">
        <property type="protein sequence ID" value="KJY24752"/>
        <property type="gene ID" value="VR44_34410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3861"/>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="437" mass="45806" checksum="F96F682A1FDCD374" modified="2015-06-24" version="1" fragment="single">PAAGPPAGTPATADLANRARASLADAVRLARWAELNLGTGDGGRPAPAGALPAVDVERAAAELGLTHGQIRVGWDRARLSGLVEVHGGQARPGWRLRAWDRDDTAVLRGWVALFDAWSLVHPAPADITPSAVAEVVEAMPQLLSLLQLSAGPVTVPDLLDLLGQRVTELRDERCEVPYDAEPAPAPASGSASAEPRPLPIARLLRWALGGLAAVDAVTLGPAQATLTPLGSWAVWVKLEQICVAAQSPAGNIEQSAAAMLHGCARLTPGPARAEYRAWLAARPVGHAVSELLHAARGEDALLRGLAFEALRVVGAPAEPEVRAAVREPALRPYALLWLAEHDGVDPDDAQDVLTPEESTWLWVDTAAAIADHGEADLLARHLDSAVRTTVPRLLDEVRAVGHPRTVQVLVALAAAHPDPALAKAVRRAAFQVHTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS16</accession>
    <name>A0A0F4IS16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001168">
        <property type="protein sequence ID" value="KJY24797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24797">
        <property type="protein sequence ID" value="KJY24797"/>
        <property type="gene ID" value="VR44_34290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3835"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="28033" checksum="2DE581E81DB8D68E" modified="2015-06-24" version="1">MSTGAGTDGGDGRRRWRREEVAREAGVKVRNLRYYQERGLLPPPRREGRIAWYSEDHLTRLRLISDLLGRGYTVNGIGELLAAWEQGGGISQLLGLEREMTRDWVREEPVTMTRAELRELFGPGATAEHTRRAAELGYVRVDGDRVTYPSRRLLEATVALVRQGMPLGEILDAGEFVQEQADALADRFVGLFRRHVIGADGLGSLSATQLDHVREAAAALRPVAGEVMASEFARAMGRRVEAEVAELLRTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISD7</accession>
    <name>A0A0F4ISD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001204">
        <property type="protein sequence ID" value="KJY24564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951678.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24564">
        <property type="protein sequence ID" value="KJY24564"/>
        <property type="gene ID" value="VR44_34990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4047"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="306"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="491" mass="54051" checksum="CADA98727ACBE484" modified="2015-06-24" version="1">MSGREAACDPREIASLFLFEKLSPEQLGRLCSEGRVERFEAGPVYTEGEPATCFYVMLEGTVVMYRRVGADDVEVSRTSQRGVYAGAMQAYLGDRVPQRYVNSMRVTGPTRFFVLSAQSFADIMQEWFPMAAHLLEGLFFGAKDTQRAIGQRERLLALGSLSAGLTHELNNPAAAAVRATEALRERVGKMRHKLAVIARGPYSREALAELIEIQERTAERVAKAPVLSPLEAADREDELADWLEDHGIPEGWRIAPAFVQAGLDTDWLEQVAATVAQDVLPGAVGWLNYTVETELLMDEIGDSTARISHLVDAAKQYAQLDRAPHRDVDVHELLDSTLLMLSGKIGPRVRVTKEYDRSLPEVPAYPAELNQVWTNLIDNAVSAIGSAGGEGTLTVRTAREGDRLLVEFRDTGPGVPPEIRDRIFDPFFTTKPVGEGTGLGLDISWRIVVNKHHGSLEVRSVPGDTRFRVLLPLTAPEGDAEPEPAPTEERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISE9</accession>
    <name>A0A0F4ISE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001200">
        <property type="protein sequence ID" value="KJY24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24579">
        <property type="protein sequence ID" value="KJY24579"/>
        <property type="gene ID" value="VR44_34950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4067"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16008" checksum="C5B2344AA7D4610F" modified="2015-06-24" version="1" fragment="single">TGGASGAGASAGASAAAKPSAAPPSAKAPAGGASAGAAAPAGGCGQPPKLPAGHKMVEPVAPPSKGSMSAKDAQPTCTPNDWIYHGKGEAKYYLFATGEVKAELATGSGSTKTVPVGELWMHAGDCMTNPSAVKAPYSCSGNIYDITVDGEGKIDSIKEVWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITK2</accession>
    <name>A0A0F4ITK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001089">
        <property type="protein sequence ID" value="KJY25342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951268.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25342">
        <property type="protein sequence ID" value="KJY25342"/>
        <property type="gene ID" value="VR44_32765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3365"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="2">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="32825" checksum="7FF5B9227B72F4C5" modified="2015-06-24" version="1">MYTRQNQKNLTAAQKKRFTSALLELKRNGVYDEFVRTHGTYFVPDRDTKLRVGHMSPSFFPWHRSYLLEFEKRLREVDPQVSVPYWDWTTDSSPVSSLWAEDFLGGTGREGDLQVTTGPFAHRRGNWTITEGVSEAPFLTRNLGRPGNPISLPTAAELQWAIDDPVYDSSPWNSTTGGGSFRNKLEGWAAPKSERWRNHNKVHQWIGGHMTGATSPNDPAFWLHHAFVDLIWDRWQQRHPGSGYLPAAPLELGDLQRGRVIALDEPMPPWDVTPREMLGHGGVYRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU14</accession>
    <name>A0A0F4IU14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001065">
        <property type="protein sequence ID" value="KJY25500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25500">
        <property type="protein sequence ID" value="KJY25500"/>
        <property type="gene ID" value="VR44_32310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="16799" checksum="C5387011B93D618C" modified="2015-06-24" version="1" fragment="single">MPDAPGAGTALATPPDLAADPLVAAVTEAAVRVLRPGAERTAAEGVPRTHLDALAACGAYGLIGYEPGPLSGLTPRQVVREVHEVLAAVDPSTWFVWTQHVPLAKALVQASGAAGTALRESWLPALVRGERRPTAGYAFLRRPHPPVTAERVPGGWRLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF2</accession>
    <name>A0A0F4IUF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001098">
        <property type="protein sequence ID" value="KJY25274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951296.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25274">
        <property type="protein sequence ID" value="KJY25274"/>
        <property type="gene ID" value="VR44_32925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3405"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="34780" checksum="E35FEBE6CED318CE" modified="2015-06-24" version="1">MEQRHLGRTGLRVSRIGLGTLTWGRDTGEEAAAEQLKTFWEAGGTLVDTADVYGGGESEYLLGRLVGGLVPRRDLVIATKAGSVPDPDRRFDGSRGHLLAALDDSLDRLGTDHVDLWQIHAFDPYTPLDETLQALDLAVSSGRARYAGVSNFSGWQLAKAATWQLAAPGARTRLASTQMEYSLLQRGVEREVLPAALDLGLGLLPSSPLGRGVLTAKYREGTPADSRGASASLAAFVEPYLDEAAGRIVDAVVTAAQGLAVTPLQVALAWVRDRPGVAAPIVGARTSAQLAAALSVEALSLPEEIRRALDDVSAPVHRYPDQDWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUG6</accession>
    <name>A0A0F4IUG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25118">
        <property type="protein sequence ID" value="KJY25118"/>
        <property type="gene ID" value="VR44_33355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3548"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18046" checksum="FDD0F2C5EEB0948B" modified="2015-06-24" version="1">MIRNAIGSLMGLIGAAAVVWSPFRAWYDGRPGRDYRIEELFSGSGVTTDPPALPGSLLLPMLFAALLVLVAVLRRSRPLMAVAGVVVLGVAVLWMVRQGQAAGGLSVGADGQGLGDGLATAFGAGALLLLAAAVMRGRRRRPRRHDRDLDLDPLARPPAAQYEPWGPADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUZ2</accession>
    <name>A0A0F4IUZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_32485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001073">
        <property type="protein sequence ID" value="KJY25439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951220.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25439">
        <property type="protein sequence ID" value="KJY25439"/>
        <property type="gene ID" value="VR44_32485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3301"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="479"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="513"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY25439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="802" mass="85893" checksum="63AF40AD32E8A7BB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV05</accession>
    <name>A0A0F4IV05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001018">
        <property type="protein sequence ID" value="KJY25852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25852">
        <property type="protein sequence ID" value="KJY25852"/>
        <property type="gene ID" value="VR44_31450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2781"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23285" checksum="B114C6DFFA17F7F1" modified="2015-06-24" version="1">MPPVPAGPADPTVLHPMPEHPRVVLLKPLLKSPLIEVGDFTYYDDPDDPTAFETRNVLYHYGPERLVIGKYCALGTGTRFIMNGANHRMDGPSTFPFPTMGGSWAEHFDLITGLPGRGDTVVGNDVWFGHGATVMPGVRIGHGAIIAAGAVVTGDVPDYGIVGGNPARLIRTRYEATDVARLLAVAWWDWPLQHITEHIRTIMSGSIDDLENAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV47</accession>
    <name>A0A0F4IV47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001087">
        <property type="protein sequence ID" value="KJY25358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951260.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25358">
        <property type="protein sequence ID" value="KJY25358"/>
        <property type="gene ID" value="VR44_32710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3355"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24654" checksum="428ACE26E5D0D682" modified="2015-06-24" version="1">MGAFSRADGARHPHHPRTYEISDPEEIRAYRAVVRLGHELAGPDPVFCSCGDDTGAHPSPERDRLLDPLSPEGIPARHRARWVAAAPAAVREYAGALAAGAEDPDLPRGVPPALVFGWLGAVREEPRDAAWLLAERGPSRLLAGLPTEELAWAVRETDRAGLEGAVRFFASEEFTTRHPKRRRVPDTARDRLLRHARGHRPADLPVLERRLLRTPDDRIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVM9</accession>
    <name>A0A0F4IVM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001033">
        <property type="protein sequence ID" value="KJY25694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25694">
        <property type="protein sequence ID" value="KJY25694"/>
        <property type="gene ID" value="VR44_31800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470180" evidence="2">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="16730" checksum="0D86D23F2DA69BCE" modified="2015-06-24" version="1" fragment="single">MSTPSTAHARIRRAALPPLTALALTVLGAAVAGPALAHGDTLNVVITGQRAGHVTADVTWENDGDAVEEAVAATVNAVSADGTRTEGPWKLVRDPGRAAGWTTTETLPAGTWTVTVEAGFPSLGRARKEVGVPVADPAPTAGAPTPASPSAPAAPGSSAPPAPSAPPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVR6</accession>
    <name>A0A0F4IVR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_31795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951090.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25729">
        <property type="protein sequence ID" value="KJY25729"/>
        <property type="gene ID" value="VR44_31795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3070"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="22746" checksum="5E2C676CB95E2D2D" modified="2015-06-24" version="1">MSARPDRTPLPRSFFDRPVLTVAPDLLGRILVRRTPDGPIELRITEVEAYEGEADPGSHAYRGRTARNSSMFGPPGHAYVYFIYGMWFSLNLVCGPPGHASGVLVRAGEVTVGADLAAKRRITARNPRELAKGPARLATALDVDRSLDGTDLCAGPDSPLSLLAGTPVPPDQVGNGPRTGVGGAGAAHPYRYWISGDPTVSPYRAHAPRRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVU7</accession>
    <name>A0A0F4IVU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001054">
        <property type="protein sequence ID" value="KJY25578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951150.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25578">
        <property type="protein sequence ID" value="KJY25578"/>
        <property type="gene ID" value="VR44_32115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3141"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6037" checksum="8C108B1C36D59E56" modified="2015-06-24" version="1">MSSSPTRRPGPPNQTPGAGTSLLGINLSGLIPIYNNINTNLNSPGAINTNTQTFGVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWB9</accession>
    <name>A0A0F4IWB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001027">
        <property type="protein sequence ID" value="KJY25763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25763">
        <property type="protein sequence ID" value="KJY25763"/>
        <property type="gene ID" value="VR44_31665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3042"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="443" mass="48547" checksum="B437E2ED87C48B9B" modified="2015-06-24" version="1">MYTALGLQRKLRSGEAEITVVTPEPYMTYQPFLPEAAAGAISPRHVVIPLRRVLDRCRIVIGQAQRIDHAKRTATITTLATPDEGTGDHEIEYDELVLAPGSVSRTLPVPGLADYGIGFKTVEEAIGLRNHVIEQMDIASSTRDPAIRDAALTFVFVGGGFAGVEALGELEDMARYAARYYHNIKAEDMKWVLVEASDRILPEVGPEMGTYTVRELRRRNIDVRLETRLESCENRVAVLSDGSRFPTRTVVWTAGVKPHPVLAATDLPRNERGRLRCTSFLTVEGVEHAWAAGDAAAVPDITAAEPGSECAPNAQHAVRQAKQLADNIVAALRDEALTEYAHKYAGSVASLGLHKGVAHVYGRKIKGYPAWFMHRTYHLSRVPTFNRKMRVLAEWTLAGLFTREIVSLGSLEHPRAEFELAAGGGHRHHPPGPTPTPPGDDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWC3</accession>
    <name>A0A0F4IWC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001142">
        <property type="protein sequence ID" value="KJY24961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24961">
        <property type="protein sequence ID" value="KJY24961"/>
        <property type="gene ID" value="VR44_33850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6373" checksum="CC0F2BA8BFACA634" modified="2015-06-24" version="1">MVAGALAADASAPLAAGGGVLAREMVRVNHYGPAASREAVVASLRALASALSADPEAALEAASAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWG2</accession>
    <name>A0A0F4IWG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic ring-opening dioxygenase LigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001022">
        <property type="protein sequence ID" value="KJY25808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951047.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25808">
        <property type="protein sequence ID" value="KJY25808"/>
        <property type="gene ID" value="VR44_31580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2813"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="2">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="27376" checksum="0ABB49E22A917382" modified="2015-06-24" version="1">MQRIGIIGVGEIGRALVDGLCDGVGEPPEIYLSPRGARTAAELAQRYPNDVRVCADNQDVVNRSDVVILAVRPQDRAEALAGLRIGGDRVVVSVLTGVAISELRRTLGTDAPVVRAIPLPSARERRSVTVTCPSHPAVDDLFGGLGGTLPVTDEATLNTFQVLTGTLTTHYRYLTTLADWAARQGIPAESADRYLRGLFQGVGRALGDDTRSMQQLASDHETPKGLNERLRTTWFDPVNAEALTKALDALLADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWR5</accession>
    <name>A0A0F4IWR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001118">
        <property type="protein sequence ID" value="KJY25121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951383.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25121">
        <property type="protein sequence ID" value="KJY25121"/>
        <property type="gene ID" value="VR44_33375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3553"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16688" checksum="28D3128D481A68FD" modified="2015-06-24" version="1">MTTAPGADELQLLLPVPDEDGAPFWEYAARGELRVQSCASCDRLRFPPRPCCPHCGSFESGWRLMSGRGRIWSYVLPHPPLLPAYAAQAPYNVILVELWDAPHIRLAGNLVASADAPLDSVDPSRLRIGAQVQVVFTETGGMTVPRWILVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWT4</accession>
    <name>A0A0F4IWT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000932">
        <property type="protein sequence ID" value="KJY26505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950746.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000932.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26505">
        <property type="protein sequence ID" value="KJY26505"/>
        <property type="gene ID" value="VR44_29915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2364"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34940" checksum="4B9E0DAA8AD08495" modified="2015-06-24" version="1">MREIAHAAQVRELTAAGALEDPAWRAAFAAVPRHVFVPYFWTGRGAGHERLWAEDPDPERRARWLRGVYTDAPLATRLRDGELLSSSSQPSLMARMLEALQVRDGDDVLEIGAGTGYNAALLCHRLGEEHVTTVDLDEEITESARAHLALLGYRPAVVTGDGARGCPSRAPFDRILVTCTLPLIPHAWLAQCRPGARILAPLSTGLIALTVRDADFAEGRFLHTSAYFVPLRGATAGPPPPGMGGPLHGVPYELVENERFQFLLILTAGVLRPREALDLWRGEGRPARERFGVTVTPEGQWAWLDDPQGPYVWPLGTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYI7</accession>
    <name>A0A0F4IYI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000930">
        <property type="protein sequence ID" value="KJY26518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950742.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000930.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26518">
        <property type="protein sequence ID" value="KJY26518"/>
        <property type="gene ID" value="VR44_29890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2358"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="20747" checksum="4B4DA304EE797709" modified="2015-06-24" version="1">MESTLVALAGTTIAVMGTLLAPVLSQRLLSRAQSDQFERQERAADAQWAREQRVAERDKQRECYVAANAGYRRYRVELMNHLWRVHKGEVTPEARASLDAARHAMHATFAEAQMVASDAVLAELDAMAVSLAHAYDRVMRLEEADTSPEEVFEEIRVMLLRANDQWIGMRGVMRADLGVEPGPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYK8</accession>
    <name>A0A0F4IYK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000869">
        <property type="protein sequence ID" value="KJY27110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27110">
        <property type="protein sequence ID" value="KJY27110"/>
        <property type="gene ID" value="VR44_28450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="19607" checksum="1DE5341E0746F71E" modified="2015-06-24" version="1" fragment="single">LLGRAPVPVVLAVAVLGGSCGPVVTGGLSSLVAGLVPEGPRRDRAYGWDASTYNAAAVTAPAVVSLAGAAFSAGPAMGVLALSAVLAAALAASLPYADADPGAGSPPERPRAGLGAGLAALWRVRELRAITSATTLAFVGVGALTTTSVLLARGLGSPGAGGVLMTAFALGALAGSLTLGRMTSVAPARLARWAMAGTGAALAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYQ1</accession>
    <name>A0A0F4IYQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950623.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000904.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26789">
        <property type="protein sequence ID" value="KJY26789"/>
        <property type="gene ID" value="VR44_29220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2189"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470411" evidence="2">
        <location>
            <begin position="38"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="248"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="54827" checksum="F6B9216D648B003D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZB7</accession>
    <name>A0A0F4IZB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000844">
        <property type="protein sequence ID" value="KJY27357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27357">
        <property type="protein sequence ID" value="KJY27357"/>
        <property type="gene ID" value="VR44_27785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1795"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8821" checksum="7A50AA38439186CC" modified="2015-06-24" version="1" fragment="single">MPVLTQKDNRPARPAPLRGGICAPLTWAKSVRGAARERGAVLVARDGEVSVIAMYEIKGVNATPGGRRTVRFHDHGYAVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZR6</accession>
    <name>A0A0F4IZR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1135"/>
    <dbReference type="EnsemblBacteria" id="KJY27149">
        <property type="protein sequence ID" value="KJY27149"/>
        <property type="gene ID" value="VR44_28355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1995"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="39950" checksum="375E3C273B9335AF" modified="2015-06-24" version="1">MERGRSALGPALELVHTGRAPTRAVLTAELGVTRATAGAVAAELEALGLIRVDSRPGGAGGAQGRPSHRLAVEENGPVALAAQVHSDGFRAALVGLGGRIVATAPGKVTVSADPAQVLGAVVGAGAELLAASGRRCIGAGLAVPSAVAEPDGTALNPLHLAWPAGSPVRAIFAECVKAAGIDGPALTGNDVNLAALAEHRHGAGRSAQHLLCVATGHRGVGGALVLDGRLHSGSSGLALEVGHLTVNPEGRPCHCGSRGCLDVEADPLAFLTAAGRTPGPEVSLLQQARDLLRAEYAQPSVRAAAEELIDRLGLGLAGLVNILNPDRIILGGLHRELLYADPERLRAVVADRSLWGRSGGVPILPCTLDHNSLVGAAELAWQPVLDDPLGTLGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZY9</accession>
    <name>A0A0F4IZY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000817">
        <property type="protein sequence ID" value="KJY27585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27585">
        <property type="protein sequence ID" value="KJY27585"/>
        <property type="gene ID" value="VR44_27230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1582"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="24446" checksum="141A4A41B5CED1C0" modified="2015-06-24" version="1" fragment="single">MTPTKWVRIWNERLPDTPLTLVGVTAGEAFAALRAGEADAGFVRLPVDGADLSAIPLYTETTVVVVPKDHVVAAVDEVATEDLADEIVLHPLDDVLGWETPPGKPAFERPATTADAIELVAAGIGVLVVPQSLARLHHRKDLTYRPVTDAPASRVALSWPEEKTTDLVEDFIGIVRGRTVNSSRGRQPAQPQPKQDRKAAAAKKTGAKPRATGKPAAKSGGKPNARGGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0G7</accession>
    <name>A0A0F4J0G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_26795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000799">
        <property type="protein sequence ID" value="KJY27762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950181.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000799.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3171"/>
    <dbReference type="EnsemblBacteria" id="KJY27762">
        <property type="protein sequence ID" value="KJY27762"/>
        <property type="gene ID" value="VR44_26795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1517"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="140"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="255"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="45167" checksum="D518E20146BE7614" modified="2015-06-24" version="1">MDFAFDTRTEELRGRLLAFMEECVYPAEAVAVGQRARLASPWDTPAVFGELKAEARRRGLWNLFFVNQHGLPDEEYGAGLTNLQYAPLAEITGRSPHLAPMATNCAAPDTGNMELLAQFGNERQKKQWLEPLLAGEIRSAFAMTEPEVASSDATNIETRIERDGDAYVVTGRKWYISGAMNPDCKVFIVMGKTDPGGADPRRQQSMVLVPRDTPGVEVRRAMTVYGYADHDHGGHAEVVFDGARVPAENLIGEEGAGFAIAQARLGPGRIHHCMRLIGMAERAVELMCRRAVGRTAFGRELAAQGVVQNWIADARVTIEQLRLLVLKTAWLMDTVGNRGAHTEIQAIKIATPRAVVEILDRAVQLHGAGGVSQDFPLAELWAAARTLRLADGPDEVHQRSLAHRELKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0P6</accession>
    <name>A0A0F4J0P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950135.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27855">
        <property type="protein sequence ID" value="KJY27855"/>
        <property type="gene ID" value="VR44_26570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1439"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13550" checksum="769E38B7CD1D036C" modified="2015-06-24" version="1">MTERDAPRALAHPEREEIRLEGVLHALSDPLRLSIVRELADREVELACSDFVLPVTKSTTTHHFRVLRESGVVRQIYRGTAKMNGLRREDLQSLFPGLLDTLLTAAAAEETRLGPQAQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1B5</accession>
    <name>A0A0F4J1B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26716">
        <property type="protein sequence ID" value="KJY26716"/>
        <property type="gene ID" value="VR44_29410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470620" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="13354" checksum="F92F8288243A211A" modified="2015-06-24" version="1" fragment="single">MASSRTKVWTTAAAVTGALLAVAAAPGRTPDTVARQDPGAPAARDAAVTLLVGRALDPRALDRGPAPAARWCAAPAFASGPCGTWREQRVRATAHGTADLLWNPSLGSTGTLPTAAGGPLEIALAHAEAGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3J0</accession>
    <name>A0A0F4J3J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950304.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000831.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27466">
        <property type="protein sequence ID" value="KJY27466"/>
        <property type="gene ID" value="VR44_27480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="32233" checksum="C2F616B7C3BD54E4" modified="2015-06-24" version="1">MAQRTHLGDADCSIAQALDVVGDWWTLLIVRDTARGLYRFEELQRELGVSRKVLAERLKLLVEAGVLTREPYQERPVRHEYRLTPRGRGLLPVLVALQDWGDTWVLGEGEMTATTEESSREAARVHALRGTRLPELLLPGLDGEPRDPVAETPFTVLYCFPGAYARAESYPPGWGGIPGARGCTLESCTFRDQLAEFTAAGATVHGVSTQRPDEQREFAEKEGLRFPLLSDAELGLVTALRLPTFRAAGVSRIKRLTLVVDRQRVVREVFYPVRDIEASVSAALAAVRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5X0</accession>
    <name>A0A0F4J5X0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_23635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000668">
        <property type="protein sequence ID" value="KJY29163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29163">
        <property type="protein sequence ID" value="KJY29163"/>
        <property type="gene ID" value="VR44_23635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.672"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="841"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY29163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1634" mass="166257" checksum="BE9C2076B2359829" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J629</accession>
    <name>A0A0F4J629_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29817">
        <property type="protein sequence ID" value="KJY29817"/>
        <property type="gene ID" value="VR44_22000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.280"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470190" evidence="1">
        <location>
            <begin position="23"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="516" mass="54163" checksum="0A332B1264A2065D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6U5</accession>
    <name>A0A0F4J6U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949147.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5511"/>
    <dbReference type="EnsemblBacteria" id="KJY30087">
        <property type="protein sequence ID" value="KJY30087"/>
        <property type="gene ID" value="VR44_21270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8979"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="57171" checksum="5D7090D35B9DC8B3" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J941</accession>
    <name>A0A0F4J941_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_20735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949049.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000572.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30329">
        <property type="protein sequence ID" value="KJY30329"/>
        <property type="gene ID" value="VR44_20735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8864"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="463" mass="50920" checksum="3F29F9FD4FB26E6F" modified="2015-06-24" version="1">MALHQTKDTRAEDAATDVFASALSGQVLPKYRMPEDHSSSEVVYSLLHNELLLDGNAAQNLATFCTTWSDDGVHRLMNECLDKNMIDKDEYPQTAEIEARCVNILADLWNAPAGTTGTGCSTTGSSEAAMLGGLALKWRWRARREAEGKPADRPNLVCGPVQICWEKFARYFDVELRQIPLEPGATGLRPHQLAAHVDENTIGVVAILGVTYTCDYEPVAEIAAALDRIQEEHGWDVPVHVDAASGGFVAPFLHPDVVWDFRLPRVASVNTSGHKYGLAPLGVGWIVWRTADLLPAELVFDVDYLGGDMPTFALNFSRPGGEVIAQYYLFLRLGRAGYRRVQQACADTARYLAGEIAGLGPFTLLYDGRGALPAVSYTLTDPGGAGFSLYDLSDRLRMRGWQVPSYPLPADRQETVIQRVLIRHGVTRDQIALLVEDMRRAVDHLRAVPQLTPATPSRSGFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9C2</accession>
    <name>A0A0F4J9C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30795">
        <property type="protein sequence ID" value="KJY30795"/>
        <property type="gene ID" value="VR44_19425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8494"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10509" checksum="8371E90B35EAFF79" modified="2015-06-24" version="1" fragment="single">PWMVLGRDTFAGDLLARLGIRNVYAGHPGRYPKVPAAELAGSGCDLVVLPDEPYRFTADDGPEAFPGLPAALVSGRHLTWYGPSLAQAPQVLAAAVRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9L7</accession>
    <name>A0A0F4J9L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30489">
        <property type="protein sequence ID" value="KJY30489"/>
        <property type="gene ID" value="VR44_20310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8771"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="17687" checksum="FE26D6BD428883A3" modified="2015-06-24" version="1">MTEQQQEASEDAVMTRIGQAVILLHAGDREEARNRLCEIWSEIGEEGDSLHRCTLAHYMADTQDDPADELAWDLRALSAADGLGEAVRVFYPSLHLSLAADYVKLDRPEAARVHLARARAATRALPDDGYGNGVRDAIARLERRLTAGEGPGPRPFPEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9U0</accession>
    <name>A0A0F4J9U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948699.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000515.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31132">
        <property type="protein sequence ID" value="KJY31132"/>
        <property type="gene ID" value="VR44_18820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8375"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="16465" checksum="D7971D8A9DCC7E4F" modified="2015-06-24" version="1">MQLSPAHHDERLSAPRSWWGIAALTGVAGALITLPLGTLPLLAGFVGGGALAGMLVSSMGSARVRVVNGVLAAGDSRIPVSALGEPEVLEGEEARAWRTYKADMRAFMLMRSYIPTAVRIEVTDPADPTPYVYVSTREPRALAAAVRAAQEASAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC16</accession>
    <name>A0A0F4JC16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000498">
        <property type="protein sequence ID" value="KJY31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948605.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000498.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31354">
        <property type="protein sequence ID" value="KJY31354"/>
        <property type="gene ID" value="VR44_18330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8215"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12800" checksum="AE4C34482586D418" modified="2015-06-24" version="1">MSTAPQPSAVPQPPTQPEAIRAALAQVAPHLLADFDRDRASSTARARAEVSAVPLRAFTEAWAVEVAIARHPETAARLRALEARAGEVTDLGEARNITAEISRIRNAAAAEAGIRTAGEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCD0</accession>
    <name>A0A0F4JCD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine synthase</fullName>
            <ecNumber evidence="1">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysM</name>
        <name evidence="1" type="ORF">VR44_17035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31992">
        <property type="protein sequence ID" value="KJY31992"/>
        <property type="gene ID" value="VR44_17035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7937"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7491" checksum="FA7D93A9C902826A" modified="2015-06-24" version="1" fragment="single">RELLQQEGIFAGVSTGAALHAAIGVGRKAVAAGESADIVFVVADGGWKYLSTGVYTAATTEEAIEVLQGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCS2</accession>
    <name>A0A0F4JCS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948358.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31990">
        <property type="protein sequence ID" value="KJY31990"/>
        <property type="gene ID" value="VR44_17025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7935"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15036" checksum="C09A7E76ECD85EFA" modified="2015-06-24" version="1">MDTSWWFAVVAAVAVVGVVLLPWHVRRRADAPPAPPHGLGPPPRVRAGELWSVADGRPCLVLSVRPHRESARVAWIVGKYDDRRPGVIPLPPGTVGVGGRGGFLEADRPQEVSVWEFRRMLGTLDPALWDEAKGLGGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDI0</accession>
    <name>A0A0F4JDI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000459">
        <property type="protein sequence ID" value="KJY31869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000091_gene3543"/>
    <dbReference type="EnsemblBacteria" id="KJY31869">
        <property type="protein sequence ID" value="KJY31869"/>
        <property type="gene ID" value="VR44_17250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7984"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470610" evidence="1">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9384" checksum="B904612FF7FE777F" modified="2015-06-24" version="1" fragment="single">MSAARSLTALRAIAVTAALPLLLTACGYGSEAKKEEPKAAGATAEDAKKLSASEVRIGYFPNLTHATALVGLQEGLIAKELGATQIKPQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDJ0</accession>
    <name>A0A0F4JDJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aspA</name>
        <name evidence="2" type="synonym">fumC</name>
        <name evidence="5" type="ORF">VR44_17390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000464">
        <property type="protein sequence ID" value="KJY31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948427.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000464.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5600"/>
    <dbReference type="EnsemblBacteria" id="KJY31818">
        <property type="protein sequence ID" value="KJY31818"/>
        <property type="gene ID" value="VR44_17390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8015"/>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="408"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="467" mass="49957" checksum="CC5FF879ED88C79D" modified="2015-06-24" version="1">MTDDQKSTAFRTEHDSMGEVRVPVHAKWRAQTQRAVENFPLSGQRLERAHIEALARIKAAAALVNSELGVLDEETAAAIRSAAAEVAEGRWDEHFPVDVFQTGSGTSSNMNTNEVIATLAGERLGREVHPNDHVNASQSSNDVFPSSIHIAATAAVTHDLVPALRHLELALERKAAEFAGVVKSGRTHLMDATPVTLGQEFGGYAAQIRYGIERLEAALPRLAELPLGGTAVGTGINTPPGFSAAVIAEVARTTGLPLTEARNHFEAQGARDALVETSGMLRTIAVSLTKICNDLRWMASGPRTGLAEINLPDLQPGSSIMPGKVNPVVPEALLMIAAQVTGNDAAVAVAGAAGNFELNVMLPVMARNLLESIRLLANGSRLLADRTVDGITANTERAREYAESSPSVVTPLNRYIGYEEAAKVAKRSLAERKTIRQVVLESGYVDRGVLTLQQLDEALDVLRMTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE02</accession>
    <name>A0A0F4JE02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="15" type="ORF">VR44_16885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948333.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000033_gene6700"/>
    <dbReference type="EnsemblBacteria" id="KJY32029">
        <property type="protein sequence ID" value="KJY32029"/>
        <property type="gene ID" value="VR44_16885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7813"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5013991374" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013991372" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="14788" checksum="FA19082B13AAB883" modified="2015-06-24" version="1">MLRTMFKSKIHRATVTQADLHYVGSVTIDADLLDAADLLPGELVHIVDITNGARLETYVIEGERGSGVIGINGAAAHLVHPGDLVILISYAQVEDAEARTLEPRVVHVDGDNRIIELGADPSAPVPGTDQERSPHAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEC9</accession>
    <name>A0A0F4JEC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000397">
        <property type="protein sequence ID" value="KJY32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32707">
        <property type="protein sequence ID" value="KJY32707"/>
        <property type="gene ID" value="VR44_15375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7434" checksum="056C19302C9011B8" modified="2015-06-24" version="1">MALLDDPDPGTRCRARERVAGWNWLATLDEGEAARAELGELLARAARLLGADELRLNHSPWSRPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEP0</accession>
    <name>A0A0F4JEP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000392">
        <property type="protein sequence ID" value="KJY32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32822">
        <property type="protein sequence ID" value="KJY32822"/>
        <property type="gene ID" value="VR44_15215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7379"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="38012" checksum="B9CE161024EA8E5F" modified="2015-06-24" version="1" fragment="single">LELPGLADRQRCLLLDQLADALDDTDPRALTVAHQAVELARTLGEPRLRGLTLTSLLRRIDCELDPGAYLPLQEELTEVAAAQDNPEYAWMSAYTAARIAAARNDPARMEDCLARADGIARTYELQGAFAVARLRRPMLALAQGRFDEAERELGSAVAELRARGAVDLSGLAGLAIGCIRLQQGRLAEVLPVLLAVWEQYQPHNEALTALALLAADRPDEAREVFARRAPLLPDFAYSILAALRGAAAIAFGDREAAAEVYADLLPLAGLAGGASSLSLVFRPVAQTLGELARFLGRPDEARRHFHEAVRVAAAWDSPHWEAAARAALADPPAASAPARPRPDGRISRRSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JER3</accession>
    <name>A0A0F4JER3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_18110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000493">
        <property type="protein sequence ID" value="KJY31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene918"/>
    <dbReference type="EnsemblBacteria" id="KJY31441">
        <property type="protein sequence ID" value="KJY31441"/>
        <property type="gene ID" value="VR44_18110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="20972" checksum="DA0B8ECAC1BFC8E4" modified="2015-06-24" version="1" fragment="single">MQPLEAGEPRTIGAYRLLGRLGAGGMGRVYLGRSAGGRTVAVKVVHPHFASDTEFRTRFRREVEAARRVGGEWTAPVLDADPEAAVPWVATGYVAGPSLDRAVAGHGPLPEASVRAVGAGLARALVAVHGLGLVHRDVKPSNVMLTLDGPRLIDFGIARATDGTASLTSTGVSIGSPGYMSPEQILGKGVTGASDVFSLGAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFA5</accession>
    <name>A0A0F4JFA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32895">
        <property type="protein sequence ID" value="KJY32895"/>
        <property type="gene ID" value="VR44_14935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7402"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="465"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="884" mass="96418" checksum="46304DC2F8649991" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGD3</accession>
    <name>A0A0F4JGD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32869">
        <property type="protein sequence ID" value="KJY32869"/>
        <property type="gene ID" value="VR44_15120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7442"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13852" checksum="A616D23ABFE8FEA5" modified="2015-06-24" version="1">MEGRRGESMGQPHDRERDLATVLHALGDPVRLALLRRMAEHGECACSPDGLDVPRSTLSNHWRILREAGVTRTRHVGKARLMTLRRADLDTRFPGLLDAVLAEEGRRAGELDGADGAGSCEQAPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGE0</accession>
    <name>A0A0F4JGE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">X-Pro dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000366">
        <property type="protein sequence ID" value="KJY33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947841.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000366.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33275">
        <property type="protein sequence ID" value="KJY33275"/>
        <property type="gene ID" value="VR44_14210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7189"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="146"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="38721" checksum="628A487849A92D72" modified="2015-06-24" version="1">MSDVYAARRGLLRERCAAAGNSAALITRPANVRYLAGASPLGAVLLVGPADDELFCAAPPTSEADEGRLDEGLTLSLLGGPGADPAVAAADRAAAVRADSLAVEEHHLTVARHRAVSSVAPRLRLADLGTAVEQQRLVKDEEEIACLRIAAEIADQALGELLESILVGRTERHLALELERRLVDHGADGPAFPTSVGTGPHSGRSRHRPSDRRVEEGDFLSVCLGANYRGYRCEIGRTFVIGTTPADWQIELYDLVFAAQRAGREALLPGAAYREVDHAARSVLDSAGYGEALAGCTGHGVGLEIDEDPQLAPTAMGKLDACVPVTVEPGVHLPGRGGVRIDDTLVVRPEADGGPELLTITTKELLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHL9</accession>
    <name>A0A0F4JHL9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000368">
        <property type="protein sequence ID" value="KJY33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947856.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000368.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33258">
        <property type="protein sequence ID" value="KJY33258"/>
        <property type="gene ID" value="VR44_14295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7206"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="87"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="25516" checksum="7132F753E145E57E" modified="2015-06-24" version="1">MGPRALVVVAAAALLVGGCHHQDATPPPARIPLIGQGFPPDAATARTELKGLKVEWGRNWESYEREAFGRYWSDDTDGVGGRNGCDTRDDVLRRDLSELRQGDRNPCVVVSGVLQDPYTGRELPYSYRRASQIETDHVVALGAAWRAGAYAWTPARRLEYANDLDVLLAVDKRTNQDKGSRTADKWRPPRRAYWCEYARRYTGIKAKYGLSVTPPEKTALEELLGTCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHY6</accession>
    <name>A0A0F4JHY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000335">
        <property type="protein sequence ID" value="KJY33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33825">
        <property type="protein sequence ID" value="KJY33825"/>
        <property type="gene ID" value="VR44_13155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6694"/>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="33631" checksum="CB72BABD6B055D9A" modified="2015-06-24" version="1" fragment="single">MEGPNHASAPSAPVLAAYSYCEAVTGTQARNFAYGIRLLPTDKRQAMSALYAFSRRVDDIGDGTLAPEAKLARLEDTRAVLGRIRAGEVEEDDTDPVAVALAHAARRFPIPLGGLDELIDGVLMDVRGEEYETWDDLEVYCRCVAGAIGRLSLGVFGTVGPGEHAEEYADTLGLALQLTNILRDVREDAGNGRTYLPAEDLAKFGCAEGFKDGRAPAGSDFPGLVHHEVRRARALFTEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIEREPAAVLRGRVSLPPHEKAYVAVRGLSGLDARAISRRTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI46</accession>
    <name>A0A0F4JI46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000319">
        <property type="protein sequence ID" value="KJY34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812614.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000319.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34012">
        <property type="protein sequence ID" value="KJY34012"/>
        <property type="gene ID" value="VR44_12795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6640"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8832" checksum="C37B40FD925AF8A9" modified="2015-06-24" version="1">MSVEFSEQTHRNMIDRIPQTTGREISDWLRTVDEGPSLLRFEEKVNWLLGAHELSHGQAKAIVHEYGLRRAARRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIB4</accession>
    <name>A0A0F4JIB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal subunit interface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947772.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33503">
        <property type="protein sequence ID" value="KJY33503"/>
        <property type="gene ID" value="VR44_13840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7047"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038611">
        <property type="entry name" value="Arr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021975">
        <property type="entry name" value="Rifampin_Arr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12120">
        <property type="entry name" value="Arr-ms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arr-ms" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="15293" checksum="F83DF8946D352C96" modified="2015-06-24" version="1">MDEVLDEGPFFHGTKADLQVGDHLTAGFRSNYRPEIVMNHIYFTALRDGAGLAAELAAGDGKPRVYVVEPTGAFENDPNVTDRKFPGNPTRSYRSRHPLRVVGEVTDWTRQTPEALQVWRDRLAAIRTDDRAEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJD7</accession>
    <name>A0A0F4JJD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000288">
        <property type="protein sequence ID" value="KJY34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947417.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000288.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34437">
        <property type="protein sequence ID" value="KJY34437"/>
        <property type="gene ID" value="VR44_11905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6386"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="12764" checksum="7F85DC0E1A99E2CD" modified="2015-06-24" version="1" fragment="single">AESVLAPHTPGPPQHRHAEHDEGFYVVSGTVRFTVGRDSHDAPAGTLVVVPPGAPHTFANVTDEPAVMLSTFTPGRYAQYFRDLGGMLADGRPLTPEANITAMARYATRPATEFPAAPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJX7</accession>
    <name>A0A0F4JJX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000366">
        <property type="protein sequence ID" value="KJY33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3357"/>
    <dbReference type="EnsemblBacteria" id="KJY33276">
        <property type="protein sequence ID" value="KJY33276"/>
        <property type="gene ID" value="VR44_14215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7190"/>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19509" checksum="57264AA03038B3D7" modified="2015-06-24" version="1">MLLIGPAGAGKTTVARHWAATRPVPTAHISLDDVREWVRSGFADPQAGWNDHSEAQYRLARRTCGFAARNFLANGISCILDDAVFPDRPVVGLGGWKRHVGPALLPVVLLPGLEIVLDRNAARSGNRRLSDEEVARIHGRMAGWYGSGLPIIDNSHLDVEATARALDEALARALASPPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKW6</accession>
    <name>A0A0F4JKW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947397.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34449">
        <property type="protein sequence ID" value="KJY34449"/>
        <property type="gene ID" value="VR44_11805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6366"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016538">
        <property type="entry name" value="UCP008292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008292">
        <property type="entry name" value="UCP008292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="25659" checksum="AD49375C7F531539" modified="2015-06-24" version="1">MIRVAAVGDIHLAPGAEGTLRPAFETLGDHADLLLLAGDLTRHGTPQEAAVVAGEVAGLPVPVVAVLGNHDHHADRPQEVTAVLAAAGVTVLEGQAVVLDLDGTTVGVAGAKGFGGGYAGRCGSDFGEPEMKAFMRHSRTCADGLRRALGDLAQAGTGLRIALTHYSPVPDTLAGEPPEIHPFLGSYLLAEAIDEVGADLAVHGHAHLGTEHGITAGGVRVRNVAMPVIDRAYAVYHLTPRPRPEEPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL56</accession>
    <name>A0A0F4JL56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">VR44_10880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003983763.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene459"/>
    <dbReference type="EnsemblBacteria" id="KJY35077">
        <property type="protein sequence ID" value="KJY35077"/>
        <property type="gene ID" value="VR44_10880"/>
    </dbReference>
    <dbReference type="GeneID" id="66855455"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6056"/>
    <dbReference type="eggNOG" id="ENOG5032RUK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9955" checksum="C6EC6C3BD423B567" modified="2015-06-24" version="1">MTELFQELLVEEADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLA5</accession>
    <name>A0A0F4JLA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947269.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34960">
        <property type="protein sequence ID" value="KJY34960"/>
        <property type="gene ID" value="VR44_11110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6106"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="366" mass="39258" checksum="2FAA18A7BF2DE6E0" modified="2015-06-24" version="1">MRLSFLQPLYAESGPFASVYLDTSRDVEQPDRAVALRWNRLRADLTRQGADRALLGVLEEAVGADAELPGMHGQAIFAANGALVLDGELPRPPARDTARYSTLPEAVPLVSQHLPEIPYLAVVVHYGGLPTAETHGWVRVEAEAGTWPASTVAPGERLHREEPVATWHHGAVRLGHRLDSWARRTHADAVVVGGDEWAGNVLVRRLPHALRSKVVRVRGATPTDTGRALLESQLDGVFRGRMAAHDRELVDVFIGRRALHGPVSEGLAATVAALQRGQVAALLLNRVPTAPLRLWTGPGPAQLALTEGELLACGVRAPREEPAGEALVRAVVGTAAELVVVPEDDLELAEGVGALLRYADRRPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLY9</accession>
    <name>A0A0F4JLY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_12890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000324">
        <property type="protein sequence ID" value="KJY33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33946">
        <property type="protein sequence ID" value="KJY33946"/>
        <property type="gene ID" value="VR44_12890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="11533" checksum="03F982F2EBB638FE" modified="2015-06-24" version="1" fragment="single">MSGTRAEAAPGSVAPAGSAGRVLALCCAATFLAFLDSTVVNVAFPDLRHAFPEVPTARLTWVVSAYAVLFAALLAAAGRLADTLGRRTLFLGSTLAFTATSLAAGAAPTAGLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMC3</accession>
    <name>A0A0F4JMC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947268.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34959">
        <property type="protein sequence ID" value="KJY34959"/>
        <property type="gene ID" value="VR44_11105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6105"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16518" checksum="58D0E54D6B0A981A" modified="2015-06-24" version="1">MTAFQLTSPAFADHREIPRRHTGEGEDLSPPLTWTAAPEGTAELLLLCEDPDAPGPAFLHWLVTGIDPWTGGVEEGRVPHGGRSWPNGFGRLGWGGPMPPPGHGPHRYFFHLYALSQPVLLRERPDVNAVHGAVRDRQLAGATLVGTYERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMR2</accession>
    <name>A0A0F4JMR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="4" type="ORF">VR44_10100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947080.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3218"/>
    <dbReference type="EnsemblBacteria" id="KJY35475">
        <property type="protein sequence ID" value="KJY35475"/>
        <property type="gene ID" value="VR44_10100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5620"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27717" checksum="C9522855924B6A7B" modified="2015-06-24" version="1">MSTPFYVSPQQAMADRAEYARKGIARGRSLVVLQYADGIVFVGENPSRALHKFSEIYDRIGFAAAGKYNEYENLRIGGVRYADLRGYTYDRDDVTARGLANVYAQTLGTIFSSAGEKPYEVELVVAEVGATAAGDQIYRLPHDGSIVDEHGSVAVGGNAEQISSYLDQRHQDGMTLSEALKLAVQALSSQANGADKTIPAERLEVAVLDRTRSQQRKFKRIRGRQLSRLLEAEVPAAAQVDAVSNDEAPEDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNI3</accession>
    <name>A0A0F4JNI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000201">
        <property type="protein sequence ID" value="KJY35760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946927.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000201.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35760">
        <property type="protein sequence ID" value="KJY35760"/>
        <property type="gene ID" value="VR44_09285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5184"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470725" evidence="3">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="94"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22794" checksum="60C4E84E52073D35" modified="2015-06-24" version="1">MTKRRPHRASAATAVVGLVIAGVHLLGATSAHADDPKPSVPPGTEPSSAAPVPIDSNAPGLKIPQGGTLAPIKVLDIAEVVEDLGGEQRRQETNQNVMMALQSEVLFPENSAVFNAQAAARIQAIAQEINTQKATRIRVFGFTDDQGSYEHGKELSKQRADAVQAELAKTVTTPGVTYDVRGYSEDYPIADNSTEEGRKKNRRVEITFPRGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNV0</accession>
    <name>A0A0F4JNV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000183">
        <property type="protein sequence ID" value="KJY36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946837.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000183.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36042">
        <property type="protein sequence ID" value="KJY36042"/>
        <property type="gene ID" value="VR44_08785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5002"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="391"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="51895" checksum="3885BD102792DA4A" modified="2015-06-24" version="1" fragment="single">VGISDELRAQIGDLPSGHGILGELIRHPQALRLPELSEHPASYGFPAHHPPMHSFLGVPIRVREEVFGNLYLTEKRGRADFDPEDEAVLSTLAVAAGIAIENARLFEEVRLRERWLEAGADITSALLSGTPQDEVLRGMLERAKDITGADMGVFYLLGTGGELRGSLALGEGAEAHRGIVLPSTRGTLAEAALARDGLITVTDVATDARVTVQPERWQGFGPAVAVTVGTKEKLSGVLMLARRKARPGFAPSEVAALPGFAGQAALALELADRRRDAEQMSMLEDHDRIARDLHDLAIQRLFATGMTLQSAQRFVDHPEAAERLARAVDDLDATIKIIRSTIFGLRERETPALGSELRARAVQTLDEAAAGLGFAPALRMEGLIDTDVPPAVADEALAVLGEALTNVARHARAGHAEVMITAVDGVLTVAVTDDGTGMPESGRRSGLRNLSERARRLGGRMTVASPGPGGHGTRLEWRVPLTPSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP14</accession>
    <name>A0A0F4JP14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947045.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7056"/>
    <dbReference type="EnsemblBacteria" id="KJY35584">
        <property type="protein sequence ID" value="KJY35584"/>
        <property type="gene ID" value="VR44_09840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5514"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="225"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="246"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="768" mass="83894" checksum="0A88A78949F0C0CF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPA0</accession>
    <name>A0A0F4JPA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_09870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947039.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000213.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35578">
        <property type="protein sequence ID" value="KJY35578"/>
        <property type="gene ID" value="VR44_09870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5520"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="133"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="540" mass="60123" checksum="AF4AFCBFE7E6B651" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPH7</accession>
    <name>A0A0F4JPH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946983.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35658">
        <property type="protein sequence ID" value="KJY35658"/>
        <property type="gene ID" value="VR44_09585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5318"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="937"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1282" mass="141138" checksum="156C5E050025A1D7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQD0</accession>
    <name>A0A0F4JQD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_08775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000182">
        <property type="protein sequence ID" value="KJY36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36049">
        <property type="protein sequence ID" value="KJY36049"/>
        <property type="gene ID" value="VR44_08775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4999"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="860" mass="88886" checksum="6132B2835785791E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQV7</accession>
    <name>A0A0F4JQV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946732.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36234">
        <property type="protein sequence ID" value="KJY36234"/>
        <property type="gene ID" value="VR44_08240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7070" checksum="3B9EF33DC300BEAA" modified="2015-06-24" version="1">MSINTAAGRGVWLAIVLLASLSVAIGAGFVLFLVGVEVKLVLGGAGATFLGLAPLGLAACRFVVEGPQGADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRC0</accession>
    <name>A0A0F4JRC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_08225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000167">
        <property type="protein sequence ID" value="KJY36308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042813727.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000167.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2962"/>
    <dbReference type="EnsemblBacteria" id="KJY36308">
        <property type="protein sequence ID" value="KJY36308"/>
        <property type="gene ID" value="VR44_08225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4397"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="45"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="34485" checksum="CFAB337450A59869" modified="2015-06-24" version="1">MLGPAILAASRSDKMRRIVSAAPVTKPVVNRFIPGETVDQVIPIVEELTRKGLEVTLDVVGEDITAVEQSYAARDAYLELIERLKELGLGEAVEMSVKLSMFGQALEGGHELALANVRPVVEAAAAIGTTVTLDAEDHTTLDSMFAIHEELRRDFPQTGCVIQAYLFRTEADARRLAAAGSRVRIVKGAYKEPAEVAYQDKAEIDKAYVRIMRILMEGEGYPMIGSHDPRLISIAQELARQAGRKLDEYEFQMLYGIRSEEHLRLASEGHRMRVYTAYGTDWYGYFMRRLAEKPANLLFFLRSMITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRH7</accession>
    <name>A0A0F4JRH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">VR44_07140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4615"/>
    <dbReference type="EnsemblBacteria" id="KJY36800">
        <property type="protein sequence ID" value="KJY36800"/>
        <property type="gene ID" value="VR44_07140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3772"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="180"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="37479" checksum="66E68104F54700F0" modified="2015-06-24" version="1">MTEKTTGASYAAAGVDIEAGDRAVELMKEWVKKTQRPEVLGGLGGFAGLFDASALKRYERPLLASATDGVGTKVDIARQMGVYDTIGHDLVAMVMDDIVVCGAEPLFMTDYICVGKVHPERVAAIVKGIAEGCVLAGCALVGGETAEHPGLLGPDDFDVAGAGTGVVEYDRLLGADRIRTGDAVIAMASSGLHSNGYSLVRHVLFDRAGMSLDQHVEEFGRTLGEELLEPTKIYSLDCMALTRTAEVHAYSHITGGGLAANLARVIPDHLHATVDRSTWTPGAVFDLVGKAGNVERLELEKTLNMGVGMMAVVPQESVDVALTALADRGVEAWVAGEILDRGDHTEGATLTGDYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS46</accession>
    <name>A0A0F4JS46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946369.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene71"/>
    <dbReference type="EnsemblBacteria" id="KJY37192">
        <property type="protein sequence ID" value="KJY37192"/>
        <property type="gene ID" value="VR44_06280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3010"/>
    <dbReference type="eggNOG" id="ENOG5032YQ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8678" checksum="B4CD9B7109A41AF3" modified="2015-06-24" version="1">MTSSDTPTCSAKGCRDAAVWVLAWNNPKLHTPERRKTWLACEEHREHLSQFLGVRGFLKDVVRLEEWVQPEGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSI4</accession>
    <name>A0A0F4JSI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000144">
        <property type="protein sequence ID" value="KJY36718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946564.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000144.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36718">
        <property type="protein sequence ID" value="KJY36718"/>
        <property type="gene ID" value="VR44_07355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3944"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045993">
        <property type="entry name" value="DUF5949"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19374">
        <property type="entry name" value="DUF5949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17280" checksum="4A84F3111B01E305" modified="2015-06-24" version="1">MTSTQAETDRSLLGTLSVLAWIGDPSEGHDVPYLIAYTLGDGPQGREGSEAAARGLLEEIGLQIGDVVMDGTRNPRTFPVQILLADAQIALTMPGLNATCTAPPEWVAAANESGQAYFLFATRAWPEAAPGQEVTPELLQAFAGDEAVLTSSAHCVLTVQTLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSL9</accession>
    <name>A0A0F4JSL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000189">
        <property type="protein sequence ID" value="KJY35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946861.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35921">
        <property type="protein sequence ID" value="KJY35921"/>
        <property type="gene ID" value="VR44_08920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4955"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="40446" checksum="A18A876A9709A01E" modified="2015-06-24" version="1" fragment="single">MTRLPSSPEEAVVELTGITKRYPGTLANDAVDLTVRSGEIHALMGENGAGKSTLMSVLYGEVRPDAGTIRLGGREVRFSGPSDAIRAGLGMVHQSFRLFDSLTVAENVLFGAEPRRRGLLDRAAARQRVAALAEEHGLPVDPDARVGTLPVGVRQRVEILRLLHRGARVLILDEPTAVLTPDEAGRLFTVLKSLATQGRSVVLVTHKLHEVLEGTDRVTVLRDGRVTARLRTRDTTAGELAEAMTGRRVDLDRVHPPGTPGPEVLTVTGVRGVDLTVRAGEIVGIAGVAGNGQSELVEALAGLRPVGTGRIELAGHDITHAPPARRRAAGLAHIPEDRTAVGTAPTASVADNLAMGHHRRRLATRRGLLRPAVLRAHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSY2</accession>
    <name>A0A0F4JSY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_08730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946824.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36066">
        <property type="protein sequence ID" value="KJY36066"/>
        <property type="gene ID" value="VR44_08730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4989"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="585"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="789" mass="87300" checksum="1CB657985A2AFB15" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSZ7</accession>
    <name>A0A0F4JSZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000127">
        <property type="protein sequence ID" value="KJY36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946482.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2763"/>
    <dbReference type="EnsemblBacteria" id="KJY36934">
        <property type="protein sequence ID" value="KJY36934"/>
        <property type="gene ID" value="VR44_06870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3458"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470850" evidence="1">
        <location>
            <begin position="29"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="54"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="36027" checksum="5C9828D110203AF5" modified="2015-06-24" version="1">MARRAVLVLSAALLASSALTACSTQGPAAGPAPGQASGAKKGAGGRITMGFAQVGAESGWRTANTKSVQEAAKKAGIELKFSDAQQKQENQIKAIRTFIQQKVDVIAFSPVVESGWDTVLKEAKDAGIPVILTDRAVDTKDTSLYKTFLGSDFVKEGKAAGEWLTAAYANEQGPVNIVELQGTTGSAPANDRKAGFAEAIRADGRFRIVASQSGEFTRAKGKTRAKGKEVMQAFLKSQKDINVLYAHNDDMALGAIQAIEESGKKPGTDIKVISVDGIKDAFVAMTEGKINVVVECNPLLGDQLMELAKKVVAGESVPARVETQEGVFPQDKAAAALPSRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTR1</accession>
    <name>A0A0F4JTR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ORF">VR44_05050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946141.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene164"/>
    <dbReference type="EnsemblBacteria" id="KJY37752">
        <property type="protein sequence ID" value="KJY37752"/>
        <property type="gene ID" value="VR44_05050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1325"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="22286" checksum="F151A9BD2863BB17" modified="2015-06-24" version="1">MTDPVTLTGDEGTIGEFDEKRAEAAVRELLIAVGEDPDREGLLETPARVARAYKEIFAGLYQKPEDVLTTTFDLGHDEMVLVKDIEVMSSCEHHLVPFHGVAHVGYIPSADGKITGLSKLARLVDVFARRPQVQERLTTQIADSLMEILDPRGCIVVIECEHMCMTMRGVRKPGAKTITSAVRGQLRDPATRNEAMSLIMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU20</accession>
    <name>A0A0F4JU20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946695.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36451">
        <property type="protein sequence ID" value="KJY36451"/>
        <property type="gene ID" value="VR44_08050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4437"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="37708" checksum="2A902CD395C3D95D" modified="2015-06-24" version="1">MTSAALRSGAWKLLEMVTTPLLPSDYLDLVSPLRSGADLRGRIEAVRPETGDAATIVIRPGRGWRGHTAGQYLRVGVDVDGRRLWRAYSITSPTNRRDGRVTITVKAVPGGKVSNHLVRRTKPGTLVQLDQATGDFVLPEAKPAKVLYLTAGSGITPVMGMLRDTEFDDAVMVHCAPQPQDVIFRDELHGLVADEKLRLIEVHTDTDGRLDLSRLDELVPDWTERETWACGPAGLLDAAEDLWREHGVQERLHTERFRPGTVVAGDGGEVTFGATGRTADADGATPLLDVGEEAGVLMPSGCRMGICFGCVTPLTAGAVRDLRTGEITEAEPGVLIQTCVSAAAGACTIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUM6</accession>
    <name>A0A0F4JUM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000103">
        <property type="protein sequence ID" value="KJY37519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946239.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000103.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37519">
        <property type="protein sequence ID" value="KJY37519"/>
        <property type="gene ID" value="VR44_05565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1926"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21432" checksum="C276FCEF05145356" modified="2015-06-24" version="1">MRPGAPGPRGRAGLVALAACVGVWLVSSGSGETVRPPLPSPADALSAQALYPGSIDPLPGSPPTRIRIPSIHVDAPLTGLGLERDGSLEVPPPARGDLAGWYRDGTAPGATGTAVIAGHVDNASGPAVFYHLGALHRGASIEVARTDGRTAVFTVHAVEVYDAKSFPDHRVYGPSPRAELRVITCGGGFSPRTGYQGNVVVFAHLTGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV90</accession>
    <name>A0A0F4JV90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_04305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946009.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4230"/>
    <dbReference type="EnsemblBacteria" id="KJY38065">
        <property type="protein sequence ID" value="KJY38065"/>
        <property type="gene ID" value="VR44_04305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.428"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="34572" checksum="BCBE6A1783C56C52" modified="2015-06-24" version="1">MSQVARSKGRIGFIAGFLVLPLALYLTFVIWPYVQTFGYSFTNWSGQSPTFDFVGLENYQALMEDEVFRGALWHNLLLLVFVPVITILLALFFAFMVNAGGRSGAGGVRGVRGSAFYKIVYFFPQVLSLAILAVLFGAVYRSDAGGLLNGFLAKLGLVDPVHPVEWLNQPDLVLWCLLLVVVWHGVGFYLVLFSAAMQSVPKDIYEAALLDGAGRAQTFLRVTLPLLWDSVQTSAVYLGIAAMDMFVLVSTMTSGQFGGGPDHHSEVMATVLMRNFLYFGKSGYACAMGVVMLLLTMILSIVTLRATRRERIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVW9</accession>
    <name>A0A0F4JVW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946076.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37903">
        <property type="protein sequence ID" value="KJY37903"/>
        <property type="gene ID" value="VR44_04700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1021"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="417" mass="45808" checksum="1B7E487A8207A1A0" modified="2015-06-24" version="1">MRLTPGPARDVDLTGVDLFDLDLYGSGDPHPLWDVMRARAPLFHQVLPDGREFWSVTRYEDVRRVLSDHREFTSERGTVPTHLGTDDPAAGVLMTSTDPPRHTEVRRPLGSKLTARAVRVWEERIRATVVRFLEPALDGAVFDLAEQALLLPALVTGPLLGIPEKDWEELVRLTAMVTAPSDPHFLLGSEAATLAISHHELLTYVRDWARTHRAAGQEDESLLHHLTSVRPGGEPLSDEEIALDGYSILLGANVTTPHTVSGTVEALMERPEQYAKAAADPTLVPNLVEEGLRWTSAACNFMRYAVDEVEIAGGTVPAGGAVVAWIGSGNRDASVFPDPHTFDITRDGAKRHGAFGFGPHFCIGAPLARMTLRVFFEELLARFESLEPAGEPQHLRSYFIAGLTHLPLTGKKRRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW67</accession>
    <name>A0A0F4JW67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946022.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38079">
        <property type="protein sequence ID" value="KJY38079"/>
        <property type="gene ID" value="VR44_04365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.441"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="33428" checksum="77435E081A98A6E9" modified="2015-06-24" version="1">MHSNRIRRIGNREVGAGRPTYVIGEIGINHNGELANALALIDAAADAGCDAVKFQKRTPEICTPRDQWDIERDTPWGRMTYIDYRHRVEFGEDEYRAIDEHCAKRGIDWFASPWDTEAVTFLEKFDVPAHKVASASLTDDELLLALRATGKTVILSTGMSTPQQIRHAVEVLGSENIILLHATSTYPAKAEELNLRVINSLEAAYPNVPVGYSGHETGLQTTVAAVAMGACAVERHITLDRAMWGSDQAASVEPGGLARLVRDIRTIETALGDGVKKVYESELGPMKKLRRVQSTLPAEDVTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW69</accession>
    <name>A0A0F4JW69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000058">
        <property type="protein sequence ID" value="KJY38612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945815.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6565"/>
    <dbReference type="EnsemblBacteria" id="KJY38612">
        <property type="protein sequence ID" value="KJY38612"/>
        <property type="gene ID" value="VR44_03215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7858"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="404"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="612" mass="66008" checksum="1117600B26D49846" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWK4</accession>
    <name>A0A0F4JWK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">VR44_05760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946272.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2537"/>
    <dbReference type="EnsemblBacteria" id="KJY37366">
        <property type="protein sequence ID" value="KJY37366"/>
        <property type="gene ID" value="VR44_05760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1967"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18247" checksum="650D3981D76B7BA5" modified="2015-06-24" version="1">MSIDVNNESGTEVDEQAILDIARYALTRMRIHPLSELSVIVVDEDAMEQLHIQWMDLPGPTDVMSFPMDELRPPSKDDEEPPQGLLGDIVLCPEVAKKQGQEAPTQHSMDEELQLLTVHGVLHLLGYDHEEPDEKAEMFGLQAAIVDGWRGERGLTGPSPAPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWU5</accession>
    <name>A0A0F4JWU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946262.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37431">
        <property type="protein sequence ID" value="KJY37431"/>
        <property type="gene ID" value="VR44_05670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1949"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="31259" checksum="32BFD24A4BA16E42" modified="2015-06-24" version="1">MAVRGFLGLSRREYTIPEPHPTGARPPKIPGELVPEHVAIVMDGNGRWAKERGLPRTEGHKVGAERVLDVLQGAIEMGVKNISLYAFSTENWKRSPDEVRFLMNFNRDFIRKTRDQLDALGIRVRWVGRMPKLWKSVAKELQVAQEQTKDNDKLTLYFCMNYGGRAEIADAAQALAEDVKAGRLDPSKVNEKTLAKYLYYPDMPDVDLFLRPSGEQRTSNYLIWQSAYAEMVFQDVLWPDFDRLHLWDACLEYAKRDRRFGGAVPNQPEGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWW9</accession>
    <name>A0A0F4JWW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38243">
        <property type="protein sequence ID" value="KJY38243"/>
        <property type="gene ID" value="VR44_04000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="19096" checksum="4969D5A4659E5EFB" modified="2015-06-24" version="1">MGAEPGVERGAEGPRKVSRVVLLDPADRILLLHGFEPDDPADTWWFTPGGGLEGDETREEAALRELAEETGITGVELGPVLWRRYCSFPFDGRRWEQDEWYFLARTTRTEIVPGGLTELERRSVTGARWWTSEELLAARETVYPTKLAGLLRTLLDDGPPGVPVVLPPEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXL8</accession>
    <name>A0A0F4JXL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042817981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37736">
        <property type="protein sequence ID" value="KJY37736"/>
        <property type="gene ID" value="VR44_05170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1349"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045436">
        <property type="entry name" value="DUF6507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20117">
        <property type="entry name" value="DUF6507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="12868" checksum="FF1132695B8C4C94" modified="2015-06-24" version="1">MDWDIKPSGVQGVVNKTITAAEGFQKAGTSLQKELPEAAKHAGTVTPGGGTGGEGGGMGPIAGALGELMASHQQRLAFISARTEASLNGAIKATTAYVQGNIEQAENAQREALKEPKVDLPGAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY67</accession>
    <name>A0A0F4JY67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945557.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39327">
        <property type="protein sequence ID" value="KJY39327"/>
        <property type="gene ID" value="VR44_01875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5779"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="44586" checksum="C59BD76D4E4B5FA5" modified="2015-06-24" version="1">MTIDTSTGTTDLPRLPQGAPAGCPYAPPESMASLRDTAPLTRVVLPDGEPAWLATSYELVREVLTHPGFSANPKAEGFPRWNLPGGTDLPVSMTHADPPVHTQLRALVSGEFTPRRIRRLRPDIERITLERCAAIEALPQPVDLVAEFATPIPALVISLLLGVPADDLAGFERNIRLVLAHDDLESSERDQAKLELLSAVTKLIADKRARADDDLLSKLITENPDMGDMELVSFVALMLFAGFSTTAHMIELSALTLIQRPDLAERARGDLSVIPALVDELLRYHSISRDSPRRAALEDIELGGVTIPAGEGVIASVQAANWDGSAFPEPDEIDLDRPRTPRHLAFGHGIHVCLGAALAKLELEVVLEELVTRYPNMRLAIPDEEIRFRTTTHLHGCYALPVDLGLEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYB6</accession>
    <name>A0A0F4JYB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37966">
        <property type="protein sequence ID" value="KJY37966"/>
        <property type="gene ID" value="VR44_04660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1013"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="577"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="658" mass="69313" checksum="3622A97DBAF5C38D" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYD0</accession>
    <name>A0A0F4JYD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39135">
        <property type="protein sequence ID" value="KJY39135"/>
        <property type="gene ID" value="VR44_02125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14390" checksum="E6A50E81077B9AC2" modified="2015-06-24" version="1" fragment="single">MSTSTTPDTLSRRVLRYAHAQGTGRSQFPTPAQVAEASGPLPDGAAGAPGSTLPYGTTELLERAAFPAGRVAGADRPAERALLAAFGLQRAELTNPYFEHRALPSVRSLFPVHAFLTGEGPARVLDVHRHALSLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYX9</accession>
    <name>A0A0F4JYX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945664.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39039">
        <property type="protein sequence ID" value="KJY39039"/>
        <property type="gene ID" value="VR44_02465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6783"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18003" checksum="085773D53ABCE3C6" modified="2015-06-24" version="1">MTTKRVLVAYGSRHGATAGIASKIGRALREDGLDAVVLPADDVDDVRGFDAVVLGGSLYAGRWNGKALHCAERNEQYLKHRPVWLFSSGPVDSSAEQHEIPPVPAVARQMERLGAREHVTFGGSITAYTPGIIARALVRHGKGGDFRNSERIRTWAHHISGELATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZE2</accession>
    <name>A0A0F4JZE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000020">
        <property type="protein sequence ID" value="KJY39475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945509.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39475">
        <property type="protein sequence ID" value="KJY39475"/>
        <property type="gene ID" value="VR44_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="37999" checksum="2683B5EAEE8A7AAB" modified="2015-06-24" version="1" fragment="single">MQFGIFSVGDLAPDPRAGRMPTEHERIRAMTALAVRAEEAGLDVFATGEHHKPPYVCSSPSTLLAYVAARTRRLILSTATTLITTNDPVRVAEEYALLQHLAGGRLDLITGRGNTPDVYPWFGQDLRETLALARENYALLHRLWRETDVDWRGRSRARLDGFTSTPRPLDGVPPFVWHASVSSPETAERAAYYGDGFFADNLLAPVGHYARLVELYRTRYADHGHGSPEQAIVGLGGQLFVRPRSQDALSEFRPYFDRSPACARHWSLEEATARTPLTVGSPDEAIEKILGFREVYGHYQRQLFTVDHAGIPLETALEQIDILGEHIVPVLRRELAAGRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZR9</accession>
    <name>A0A0F4JZR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="12" type="ORF">VR44_01830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945569.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39339">
        <property type="protein sequence ID" value="KJY39339"/>
        <property type="gene ID" value="VR44_01830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5770"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="242"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY39339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="37432" checksum="CF62345F4A5D922D" modified="2015-06-24" version="1">MTEHGPAFRGALTGLLGLGTYLPSRRITNEMICERIDTSDEWIRSRSGIRFRYWAEPTETVEFMAATAAERALEHAGIAASEVGCVIVSTVSHLHQFPSLAAGVAHRIGAAAPGAFDISAGCAGFSYGLSLASDMVAAGSARYVLVIAVERLSELLDHEDSGTAFLFGDGAGAAVVGPCDQPGVGPVVWGSDGSHKETIRQSHSWAELRDATAPDWPVITMDGREVFRWAAYQLGPIAAQALEKAGVTVRDLDSFVPHQANMRIIDELVKELGIPDHVAVARSVEIHGNTSAVSIPLAMQELLASGRARPGGLALLLSFGTGLVWGGQVVRLPPAPAGPPVPAATAPAHPTKENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I279</accession>
    <name>A0A0F4I279_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001856">
        <property type="protein sequence ID" value="KJY15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15794">
        <property type="protein sequence ID" value="KJY15794"/>
        <property type="gene ID" value="VR44_40820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7236"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6271" checksum="C7BE114A6261CE08" modified="2015-06-24" version="1" fragment="single">GRRRALRPQPRRGRACDLLVRGGPAFELLAPDGPAFDLLVRGGPALDLLALDGPAPGFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2M2</accession>
    <name>A0A0F4I2M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphinothricin acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001779">
        <property type="protein sequence ID" value="KJY16182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16182">
        <property type="protein sequence ID" value="KJY16182"/>
        <property type="gene ID" value="VR44_40575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6938"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="34" mass="3534" checksum="12B35F70C9C966E6" modified="2015-06-24" version="1" fragment="single">MVVPLTTAHATEVLAIYQAGIDEGNATFETTAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I960</accession>
    <name>A0A0F4I960_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001598">
        <property type="protein sequence ID" value="KJY18610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952528.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001598.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7191"/>
    <dbReference type="EnsemblBacteria" id="KJY18610">
        <property type="protein sequence ID" value="KJY18610"/>
        <property type="gene ID" value="VR44_39530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5995"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="35916" checksum="7A428CE74CF59EDC" modified="2015-06-24" version="1" fragment="single">SETLLFDIEHPDAPVRGCALRLAADPAAYTVFPAYDMPRQHRVMSLVAEHTDLPVPRVLWLEEDPAPLGSPFFVMARAEGRVPPDVMPYTYEGNWLHSATDAERAELQEASISLLARLHDQFPAKEAEFLLPAGQGSPLRRHVDAQRAYYAWVVEGLARSPLLERAFDRLEELWPADEGEPVLNWGDARIGNVVYDGFRPAAVLDWEMAACAPREVDLGWTVYLHRFFQDLTVGFGQPGLPDFLRREDLERRYAELTGHTPRDMEFHTLYAALRHGIVMLRIAYRQAYFGEVEVPADPDGLILHHDSLAAMVQGTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB16</accession>
    <name>A0A0F4IB16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001581">
        <property type="protein sequence ID" value="KJY18864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952499.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18864">
        <property type="protein sequence ID" value="KJY18864"/>
        <property type="gene ID" value="VR44_39375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5960"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="29017" checksum="FF2D78A5DB950935" modified="2015-06-24" version="1">MASAWEVRFRSLDGTELVGTVTAPAGVAKGCAVLVHGAGVTREEGGFFGRLAAGLATASVLSLRFDLRAHGASGGRPQDITIAGVANDVRAAVDQVRREWGADGAPHVIAASFSGGAAALHAAYRPQDVGRLVLLNPRLDYRDRYVDSRPYFEGDYISGSAARALDEAGFAEKSPFELGRALYNEVLYLAPEVYLRAVRAPVLIVHGTKDTFVPVESSRRYLRVLTGPAELLELDGAQHGFAVHEDPGYADPQTQIWQAQVIERVTGFLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBG7</accession>
    <name>A0A0F4IBG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001636">
        <property type="protein sequence ID" value="KJY17981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17981">
        <property type="protein sequence ID" value="KJY17981"/>
        <property type="gene ID" value="VR44_39775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="48"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22738" checksum="85EEBEC5E29E3704" modified="2015-06-24" version="1" fragment="single">MQNDQNGQNGQKNENEQKLLDYLKRVTADLKQTRRRLHEVEAKDQEPIAIVAAGCRYPGGVDSPEALWRLVESGTDAVTGFPDDRGWDLEGLYDPDPGVPGKCYTREGGFLHEAGRFDPGLFGMSPREALATDPQQRLLLEVAWETFERAGIAPTSVKGSRTGVFVGLAYQGYAGSGDTREELEGFLLTGTAPSVASGRLSYTFGLEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ID71</accession>
    <name>A0A0F4ID71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001598">
        <property type="protein sequence ID" value="KJY18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7193"/>
    <dbReference type="EnsemblBacteria" id="KJY18611">
        <property type="protein sequence ID" value="KJY18611"/>
        <property type="gene ID" value="VR44_39520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5993"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9704" checksum="09C8759160398FE5" modified="2015-06-24" version="1" fragment="single">MEELDRQIVDLLVRDGRMSYTDLGKATGLSTSAVHQRVRRLEQRGVIRGYAAVVDPEAVGLPLTAFISVKPFDPSAPDDIAERLAGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IFI4</accession>
    <name>A0A0F4IFI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_38550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001485">
        <property type="protein sequence ID" value="KJY20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952343.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001485.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.033"/>
    <dbReference type="EnsemblBacteria" id="KJY20795">
        <property type="protein sequence ID" value="KJY20795"/>
        <property type="gene ID" value="VR44_38550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="240"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="44444" checksum="E807CA4E9D3F3A91" modified="2015-06-24" version="1" fragment="single">MNGQQTPAPDPYFPDNGDPRYRAHRYELALDYRPAPNRLTGRARISAIAGPAALPEFRLNLAPFRVGRVLLDGRTAHYTHRAGLLRIRPAKPLPPAAAFTVEVHWSGNPKPVRSPWGGLGWEELTDGALVASQPVGAPSWYPCNDRPADKASYHISLNTPSAYTGAAGGRLLTRTTGASTTTWVYEQPAPTSSYLVGLSVGMYRTVSLDGAGPGEVLQNAHVPAHLLPRFSHDFARQPAMMRLFEDLFGPYPFGEYTVVVADEELDVPVEAQGLSAFGANHVDGARGSERLIAHELAHQWFGNSVTIADWRHIWLNEGFAKYAEWLWSERSGGRAAHELAAAAHRLLASRPQDLRLSDPGRKLMFDDRLYQRGGLTVHALRCALGDGAFFRMLRDWAVGHRHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHE6</accession>
    <name>A0A0F4IHE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_38280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001456">
        <property type="protein sequence ID" value="KJY21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952293.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001456.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21445">
        <property type="protein sequence ID" value="KJY21445"/>
        <property type="gene ID" value="VR44_38280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5265"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="5">
        <location>
            <begin position="450"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="525" mass="55945" checksum="421FD25AC2EFBB01" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQE3</accession>
    <name>A0A0F4IQE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001263">
        <property type="protein sequence ID" value="KJY24245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951854.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001263.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24245">
        <property type="protein sequence ID" value="KJY24245"/>
        <property type="gene ID" value="VR44_35925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4343"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="32533" checksum="5D7714C712D29C3C" modified="2015-06-24" version="1">MTNENTQPLVLGDVEITRVIEVQGPFVAARDLVPQSGAEVWKENEDWLAPDHWQPDADLAVLALQTWVLRSGGRTVLVDTGAGNGRERPGSPLFHRRQGDFMGRLAAAGVRPEEVDVVVNTHVHADHVGWNTVDAGGEWVPAFPNAHYLIPAADDAHFGPRGGYAGGAREIDRLVYEDSIAPVHRTGQAVLWEGSHRIDDHLTLEAAPGHTPGSSVLRLASGTDRAVFVGDMLHSPVQVLRPSCNSCFCMDPAGAADTRRRTLARAAERGELVFPAHFGGTGAFEVREEKGRFAIGGWASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRA4</accession>
    <name>A0A0F4IRA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Benzaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_36060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001270">
        <property type="protein sequence ID" value="KJY24204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951876.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001270.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000049_gene3458"/>
    <dbReference type="EnsemblBacteria" id="KJY24204">
        <property type="protein sequence ID" value="KJY24204"/>
        <property type="gene ID" value="VR44_36060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4370"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="49456" checksum="39A85C46A9CE8F0F" modified="2015-06-24" version="1">MPLLDPTLWQDGPTLTGGTAPVVEPATGRTLATLDLAAPADVAEAAVRAAAAQCDWARATHIERAAVLRRAGDLFAAHADELREWLVRESGSIPGKADFELHVAAQECYEAAALASRPAGQVLPSEAPRLSYTRRVPAGVVGVVAPFNAPLILSIRSVAPALALGNAVLLKPDRRTAVCGGLALAAVFAAAGLPAGLLHVLPGGAGTGAAVVADPRVRVVSFTGSTAAGRSVGELAGRHLKRAHLELGGNSALVVLADADVEAAVAQASWGSFFHQGQICMTAGRHLVHASLYDEYVERLAARAEALVVGDPHRERVHLGPLLDGTQLERVHGLVEGSVERGAKLVAGGTHEGLFYRPTVLAGVSDDTPAYTEEVFGPVAPVRSFTTEDEAVELAAAGPYGLSLGIVTRDAAHGLELAGRIPTGIAHVNDQTVNDEAVAPFGGVGASGTGARFGGEANLDAFTELRWTTVRRTPPGHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRV7</accession>
    <name>A0A0F4IRV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_34395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001173">
        <property type="protein sequence ID" value="KJY24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951569.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene45"/>
    <dbReference type="EnsemblBacteria" id="KJY24750">
        <property type="protein sequence ID" value="KJY24750"/>
        <property type="gene ID" value="VR44_34395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3857"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="532" mass="57805" checksum="09BE3C290E48E7C7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS75</accession>
    <name>A0A0F4IS75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001218">
        <property type="protein sequence ID" value="KJY24494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951715.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24494">
        <property type="protein sequence ID" value="KJY24494"/>
        <property type="gene ID" value="VR44_35185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4116"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046156">
        <property type="entry name" value="DUF6158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19655">
        <property type="entry name" value="DUF6158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="9171" checksum="E4797DBBD5AC0563" modified="2015-06-24" version="1">MAERSGGAAPRDLEDGRLLRELETIHRTRHETLLHGSDDALATHTQRLKELEEEYLRRHPHRAPASARTREGARARASGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISW5</accession>
    <name>A0A0F4ISW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_33485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001123">
        <property type="protein sequence ID" value="KJY25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25087">
        <property type="protein sequence ID" value="KJY25087"/>
        <property type="gene ID" value="VR44_33485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3577"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="411"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="478"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="546"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="611" mass="63929" checksum="12EB98B32B3F6015" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITX8</accession>
    <name>A0A0F4ITX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_33405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001120">
        <property type="protein sequence ID" value="KJY25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951390.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001120.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5143"/>
    <dbReference type="EnsemblBacteria" id="KJY25104">
        <property type="protein sequence ID" value="KJY25104"/>
        <property type="gene ID" value="VR44_33405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3559"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27993" checksum="2C399F50F2C40C1B" modified="2015-06-24" version="1">MPVLPGAEPFRHEGGEVGVLLCHGFTGSPQSLRPWAEYLAERGLTVSLPLLPGHGTRWQDMQLTGWQDWYAEVDRALRELLERCSQVFVFGLSMGGALTLRLAAKHGDAISGIVLVNPANKVHDPLAVALPVAKHFIRSTAGIASDIAKPGAAEVGYDRVPTKAAHSLRKFFQLVDTELPQVTQPVLLLHSPQDHVVPPVDSERILARVSSTDVTETLLEQSYHVATLDHDAERIFADSYAFVGRLAESVGREGAASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU62</accession>
    <name>A0A0F4IU62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001266">
        <property type="protein sequence ID" value="KJY24226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24226">
        <property type="protein sequence ID" value="KJY24226"/>
        <property type="gene ID" value="VR44_35975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8120" checksum="752EE43D4B5F39D5" modified="2015-06-24" version="1" fragment="single">MSARAAPPAPPLLIACALRIERAALGGAGRSAGGGTVLRTGMGPRAADRAVARALGRPGMERAAVLATGFCAGLLPGMNPGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV10</accession>
    <name>A0A0F4IV10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001017">
        <property type="protein sequence ID" value="KJY25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951012.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001017.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1411"/>
    <dbReference type="EnsemblBacteria" id="KJY25857">
        <property type="protein sequence ID" value="KJY25857"/>
        <property type="gene ID" value="VR44_31390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2768"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="43951" checksum="1CA12F6C5BBFCD80" modified="2015-06-24" version="1">MVLGLLLARAGVEVTVLEKHGDFLRDFRGDTVHPSTLSLLEDIGLAERFARLPQRRVSSVQLPIGPDRSLVTVGNLAALHGTYNYIAMVPQWDLLDLLADEAGKEPSFRLRMDTGATSFLMDRGRVTGVRYRTADGRTGELRATLTVACDGRGSLARALPELGLEGFPCPMDAWWFRLPRSEDDPSGLVGGLGDRFFTALIDRGDYWQCAALIPKGTDAERRAEGLERFMTRFTQAVPWLADRAGSVTSWDEVKLLDVRLDRLRRWHRPGLLCIGDAAHAMSPVFGIGINLAVQDAVAAARHLVRPLREGTVGLHDVRRVQLRRWPTTVATQGLQRLAHAQVIEPLLAGRTAFGDPRRAQRLTELVTESRWLNRVPAYFIGYGALRERPPKESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV15</accession>
    <name>A0A0F4IV15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001017">
        <property type="protein sequence ID" value="KJY25862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951017.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25862">
        <property type="protein sequence ID" value="KJY25862"/>
        <property type="gene ID" value="VR44_31415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2773"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20821" checksum="0FEDD7FDE6F0586B" modified="2015-06-24" version="1">MSTTDGSASARAATSGDEAGAGSGRDAIVRAARRAFTLRPYAEVTMRGIAADAGVSPSLIVKRFGSKEALFNTVADFGAAADALFAAPPPELGRHLVLTMVDLRERFGGDPLLRVVFSLGIEDERTLLRARFREQVTDRLARALTGPDAALRAELIAGQLLGLGATLSLHRPDGAGAHTSAERLADLYAPGLQRLVDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV72</accession>
    <name>A0A0F4IV72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25529">
        <property type="protein sequence ID" value="KJY25529"/>
        <property type="gene ID" value="VR44_32265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3175"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="9789" checksum="750DDB2A7FC57A82" modified="2015-06-24" version="1">MLAGTMPRTAEVSNWSAAWIGLDAMLAAGLTGTGLLLRKGDPRVAPVAAATAALLVMDAWFDVTTSAGTGGQGLALLLAAGAELPLAVACAVVAARRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV98</accession>
    <name>A0A0F4IV98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001007">
        <property type="protein sequence ID" value="KJY25940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950976.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001007.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene871"/>
    <dbReference type="EnsemblBacteria" id="KJY25940">
        <property type="protein sequence ID" value="KJY25940"/>
        <property type="gene ID" value="VR44_31185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2725"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="180"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="329"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="596" mass="63925" checksum="F7314C58AC1FF71E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVR0</accession>
    <name>A0A0F4IVR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000980">
        <property type="protein sequence ID" value="KJY26120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950915.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000980.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26120">
        <property type="protein sequence ID" value="KJY26120"/>
        <property type="gene ID" value="VR44_30845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2627"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="48851" checksum="26EE927CC4EC0F33" modified="2015-06-24" version="1">MAPLSKAATALAALREDLAGEVFAPDDPGYDGARTVFNAMVDRRPAVIAQCESAADVVTAVRFARDLDLSVAVRGGGHSVAGMSLNDGGLVVDLRRMHEVAVHPAAKAVRVAGGATMSHLDRACEPYALATTGGRASTTGVGGFVLGGGTGWLDRKFGLAVDNLLGVELVTAQGELLNVTAEDHPELFWGLHGGGGNFGIATSLTLRLHELPALSIALVLYLPERGPEVIRAYRDVIESGPDEAGGGALYLTGPPAPFVPPHLVGLLLAGALVTYAGPEEELRRLAGPLLAIPHEAEVVTAIPYAELQCMLDDPPGLRNYWSAEYLTGAPDAFVDVFCARAATMPVPTGTQHVVWPQGGAIAAAKEDYPVPYRDAPWAVHPFGMWEDPADDERVIQWVRDVRADVQPWATGAVYLNFTGDEGADRVVAGLGADNMRRLARLKREYDPDNVFRFNHNIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVT1</accession>
    <name>A0A0F4IVT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001030">
        <property type="protein sequence ID" value="KJY25744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951081.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001030.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene818"/>
    <dbReference type="EnsemblBacteria" id="KJY25744">
        <property type="protein sequence ID" value="KJY25744"/>
        <property type="gene ID" value="VR44_31740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3058"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34293" checksum="C0AEB6DA81B3369F" modified="2015-06-24" version="1">MSTEQTPRGPVDSSRIPRYAGPATFARLPRLDEVGSADVAVVGVPFDSGVSYRPGARFGGNAIREASRLLRPYNPAQDASPFALAQVADAGDIAVNPFNINEAVETVEAAADELLSSGSRLMTLGGDHTIALPLLRSVAKKHGPVALLHFDAHLDTWDTYFGAEYTHGTPFRRAVEEGILDTEALSHVGTRGPLYGKQDLDDDAKMGFGIVTSADVYRRGADEIADQLRQRIGDRPLYISIDIDVLDPAHAPGTGTPEAGGMTSRELLEIIRGLSSCNLVSADVVEVAPAYDHAEITSVAASHTAYELTTIMSRQIAASKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVU9</accession>
    <name>A0A0F4IVU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000976">
        <property type="protein sequence ID" value="KJY26160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950899.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000976.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26160">
        <property type="protein sequence ID" value="KJY26160"/>
        <property type="gene ID" value="VR44_30755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2607"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23141" checksum="EF0F7CDC980A9166" modified="2015-06-24" version="1">MRSPRPYSPQSGSGAQSLTERRKAATQLDIARAACELFAAHGPDGTTAEDIAHRAGVALRTFYRYFRNKQEAVAPLLAGGGDAWRALLAEEDPATPLARALERAVTRALSDSKAVEEGLEVTRGLLRAAATDQALRAVWYRVNQESEERLAPIVARLAGPEADEMSVRLVSAAATDAIRVALELWSAGDAPVSGLGSPADLAVRCLRELTGAMPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW53</accession>
    <name>A0A0F4IW53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000961">
        <property type="protein sequence ID" value="KJY26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950851.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000961.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26265">
        <property type="protein sequence ID" value="KJY26265"/>
        <property type="gene ID" value="VR44_30505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2516"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="19195" checksum="FD83ED00544F2ECF" modified="2015-06-24" version="1">MKPPTAGAAPPGFRHRYGASPLHLLLLLASFALACYAGLRLLEGDTLGVAVWFVGAALLHDLVLLPLYAVTDLAVQKLLGPRAGQGTRVPRAGVNHVRVPAFVSGVLLLVYWPLVLGQVGHYTISTGLPADVFLGRWLLITACLFAASGAVLAVRQWNAGRTARDHPSARASAARDDHPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWI3</accession>
    <name>A0A0F4IWI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001132">
        <property type="protein sequence ID" value="KJY25026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25026">
        <property type="protein sequence ID" value="KJY25026"/>
        <property type="gene ID" value="VR44_33660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3642"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12585" checksum="470AE606D3E7FA83" modified="2015-06-24" version="1" fragment="single">PASQPSSANFDGGLSRIDVNAEGTGCSVVWNSTVKSAALPRLSLADGKIYTVSVTGPTGSAGLNTFAQYHHSVIDPATGTQLTSSFLGIGLVYNPLQMRGTAAPDGTLYQGTETGVVRISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX07</accession>
    <name>A0A0F4IX07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001002">
        <property type="protein sequence ID" value="KJY25973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25973">
        <property type="protein sequence ID" value="KJY25973"/>
        <property type="gene ID" value="VR44_31125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1544" mass="167633" checksum="AE4EB6B6B70BD34C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX16</accession>
    <name>A0A0F4IX16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001001">
        <property type="protein sequence ID" value="KJY25983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25983">
        <property type="protein sequence ID" value="KJY25983"/>
        <property type="gene ID" value="VR44_31090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="45996" checksum="58D99DCD399DCE63" modified="2015-06-24" version="1" fragment="single">MARVHPLVLRPEVTAIETPTGVDTPFQGIQLLAPATLLSFDVTTGSIDQMTWWHLEDRAPFTGTYDEALARFSTTLAEQIPLRAPACDFALLLSGGLDSAVLAYLMRPPVCVTVRYPGQDRLDESSTAAVIARDIKAELVVVEPDHVDFTTALPHMMRALDYPMGNASTFSEHMAYRKISDLGLRVAIGGLGPDEFLMGYLRQALVLFGPDAVLNSGLEAYRPLAAKLMHAVGEPLDPAEAVTRLILRGPDPDGRLRDLVADAMARAGGDLARSLTLADLATAWRPLVMTSDKLASAYALERRSPYLARDLVEFSYRLPVDYKITNPAQGKRILRDAAKALGLPKEVWDSRDKLGFASPVPSWLNGNLATWADTQIRMALTDAPPAFRLLEGGLQPGGRFDRTRMQALMAAAWFSDQTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX75</accession>
    <name>A0A0F4IX75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000914">
        <property type="protein sequence ID" value="KJY26645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950680.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000914.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26645">
        <property type="protein sequence ID" value="KJY26645"/>
        <property type="gene ID" value="VR44_29555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2286"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32645" checksum="D8563EA1546A4927" modified="2015-06-24" version="1">MQLDLNLLTALDALLEEGSVAGAAARLHVTAPAMSRSLGRIRRTTGDQILVRTGRTMTPTPYAIAVRAQVHELVHQVRGVLAPSRELDLATLERTFTLRWHESLVALSGPALLTAVRAQAPGVRLRFIGEASVDAHELRRGEVDLEANANRPGAPDIRTEKAGETRLVAVVRRGHPLARARTLTARRYAAAEHVTVSRRGNLGNAVDEALAQLGLSRRVVATAPTEAAAFAFARDGDLVISVPEATARSAAGDLGLVALPLPLELPSAPVYLSWHQRYDTDSAHAWLRGLARDALASVASGRATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXC2</accession>
    <name>A0A0F4IXC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000957">
        <property type="protein sequence ID" value="KJY26299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950830.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000957.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26299">
        <property type="protein sequence ID" value="KJY26299"/>
        <property type="gene ID" value="VR44_30385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2489"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="13569" checksum="BD81E8E1086AA065" modified="2015-06-24" version="1">METTTKTKTARELAETYFTAWEAGDFDTMRGLLADDVDFVGALGTAQGTEEALAGLKGLGRVLERIDVKVRVAEGDEVITWFELCTSIAPPAPTANWMHVEDGRISRIRVTFDPRGLLAGLGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXD2</accession>
    <name>A0A0F4IXD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_30340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000955">
        <property type="protein sequence ID" value="KJY26309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26309">
        <property type="protein sequence ID" value="KJY26309"/>
        <property type="gene ID" value="VR44_30340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2480"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="100"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="209"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY26309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="37230" checksum="895F9BBEBB98C1B1" modified="2015-06-24" version="1" fragment="single">EAHRPGARAAIGAARGLDPAAARRALAPTGYAAPHLPPPYGRGAGPAEQLVIQQELKEAGVKVADLGIATWIVPSLIAFGSEEQREAYVLPTLRGDTTWCQLFSEPGAGSDLASLRTRAERTGDGSWRINGQKVWTSSAHTADFGILLARTDPQAPKHKGLGYFVVDMKNTPGIEIRPLKEITGDSLFNEVWFEDVLLPAEALVGAADGGWKAARNTLGNERVHMADQMTFGTGLEALIAASRGLDASYGARIGALAAEAHALACIGLRTTLQQVSGLEPGAGASVRKLVQTPHQQRTAELALELLGPAGAVREGAGERAVHGMLMSRCLTIAGGTTQVQLNVVAERILGLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY06</accession>
    <name>A0A0F4IY06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000891">
        <property type="protein sequence ID" value="KJY26897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26897">
        <property type="protein sequence ID" value="KJY26897"/>
        <property type="gene ID" value="VR44_28950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2089"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="48851" checksum="FD78E8D20FDED59B" modified="2015-06-24" version="1">MSAPVTGITKRPPGLRLPAVVQTLLFAQYRHRLFPLLKRRHGDVFTLRLTTPTRHLVILTKQEDIKTVFGGPVEVLHAGEGNAIMGPALGDHSVLLTDEAEHRRSRRLLMPAFTGAALAGYQELVGELTRAEVDGWPEGTVFSSHERMQALTLEVILQVVFGVTDEARLKRMRPLVRGIADIGPVTLLGLPYPLLQRFGPWRRHIGLQRGLDKLLYAEISDRRRAPDLHSRTDVLSRLLQAAENEEGGGFSDAELRDQLITLLLAGHETTATGLAWALHELVRQPEQLKRAQQAADEGDDAYLTAVAKEALRLKPVVYEVARQLTKPLTVGGYRLPAGATVMPAIGLVQSDPAYHHQPDEFRPERFLHGQPPAHTWIPFGGGARRCIGAGFALLEATVALREVLVRYEIRPDRAAPEEQKAHHVTLIPSRGARLVVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ25</accession>
    <name>A0A0F4IZ25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000908">
        <property type="protein sequence ID" value="KJY26728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950642.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000908.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26728">
        <property type="protein sequence ID" value="KJY26728"/>
        <property type="gene ID" value="VR44_29355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2235"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469971" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="219"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="423" mass="44468" checksum="012F598BA34E47D0" modified="2015-06-24" version="1">MNRNKTALAAPIAAALLAAAVTTATPAAAAYGSPWHSAWGASPQAPTHTDWFPNWSEQGFRDQSVRQVVRAGAQGGELRGRLSNAYGKAPLRLAGATVAKSAGGAAVRPETVRTLRFGGSATTTVPAGAELSSDAVALPVQAFEQLTVTLWFQGPTGPATFHNVAMATSFRADGNHLRDAAADAFSAAGDQSFSWYYLAGIDVKDPAAPGPRRSAVVTFGDSLSDGFGATPGADRRYSDALAGRLAALGTPRPVLNAGIGGNKVLTDSPCFGESALNRFRRDALGRPDTAAVIVLEGTNDIVQPDGVQDRCTTGPRVTAQQIIAGYRELIREAHARGVRIIGGTIPPYGESGYWTARGEEVRAEVNRWIRTSGAYDAVVDFDRAVADPEHPQNLKAEFAFADRLHLNDAGYRAMAEAVDVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ53</accession>
    <name>A0A0F4IZ53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000886">
        <property type="protein sequence ID" value="KJY26919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950559.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000886.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26919">
        <property type="protein sequence ID" value="KJY26919"/>
        <property type="gene ID" value="VR44_28890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2118"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="41329" checksum="73DB897BDF897709" modified="2015-06-24" version="1">MNGEGTRAPTLLDPLRQRSFRCLAGGRMATYFANAMAPIVLSFAVLDLTGSLVDLGIVVGARSVANVALLLFGGVIADRLPRRLVLQGSSVAAGLAQAVIAASVLLGFASIPVLVVISVINGMVSALSLPAAAALVPQTVPHEMIRPANAVVRMAVNAGMVLGASAGGIVVGLAGPGWGIAVNAAVFLVAGLCFAGLRTAGTPAAPAGPARPLAELREGWSEFTSRTWVWVVVLQFLVINAVVSGGLQVLGPTIADQTFGRTTWGLLLAAQTAGAFAGGFAAVGAFEAVPLLALGTTSHVALLVAAMFINGVALEQLAVAWDVSLQENIPQERLARVYSYDALGSFVAIPVGEVAAGPIALHAGIDTTLVTGAVLVLAATGLALCSSSVRRLTVKPAAPPHRPAGEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1X8</accession>
    <name>A0A0F4J1X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000745">
        <property type="protein sequence ID" value="KJY28280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28280">
        <property type="protein sequence ID" value="KJY28280"/>
        <property type="gene ID" value="VR44_25705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1240"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13361" checksum="63373B6548E8A8D9" modified="2015-06-24" version="1" fragment="single">TTPVPTPPPTANPSTERLLRVTRSGGFAGRTRTLLVNGDGSWTLLGEQDKDLRKGRLSPSALEDLRTALREADFAHLPRTATADPPVYDGFTYSFVHGGFEVSADQTALPAALSRVLGALPGFDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J256</accession>
    <name>A0A0F4J256_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950158.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000793.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27833">
        <property type="protein sequence ID" value="KJY27833"/>
        <property type="gene ID" value="VR44_26685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1496"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470065" evidence="3">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="16792" checksum="9FA4AE937BB5CACE" modified="2015-06-24" version="1">MNRRLRAPHWTAGAALAAAALLTTAPACATSARAPLAAVRAGSDQADAVPEEAYEELAGSAGGVGREHPGLPADAPADPEVTSLSRPAHPVRPAPRPERREPVVNQRPAAPPSPSPSRGAPASALGTEPNERVADLAAHLLPLGTGLALMGLGLGYIGVRLRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2F8</accession>
    <name>A0A0F4J2F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_26445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950112.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000784.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27918">
        <property type="protein sequence ID" value="KJY27918"/>
        <property type="gene ID" value="VR44_26445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1473"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="51050" checksum="0905EED1604B6FFA" modified="2015-06-24" version="1">MNTAVVLYTSDLRLHDHPPLRAALASCDRVVPLFVRDRAVERAGFAVPNRLAFLADCLADLDAGLRTRGGRLVLRSGEVVEEVCALVREAGAGEVHLAAGVSGYAQARERRLREALRAQGCALYTHEAVITAVAPGAVLPSGRGSDHFAVFTPYLRRWSELPPRRAAAAPRTVRVPEDIGSEEPPRRSAVTGTSPGLARGGECEARRLLTRWLSSGLARYEDTHDDLAADATSRLSPHLHFGTLSPVEAAQRARAAGGPGAEAFVRQLCWRDFHHQVLAARPEAATRDYRARDDRWRTGRDAEEEVQAWKDGRTGYPVVDAAMRQLRHEGWMHNRGRLLAAGFLAKTLYADWRTGARHFLDLLVDGDVANNQLNWQWVAGTGTDTRPNRVLNPVRQGLRHDPDGRYVHRWVPELAALPAPRVHEPWKLPAEERARYDYPEPLVDLTEAQARFREGRRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J547</accession>
    <name>A0A0F4J547_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_24230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000695">
        <property type="protein sequence ID" value="KJY28893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042816067.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000695.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2968"/>
    <dbReference type="EnsemblBacteria" id="KJY28893">
        <property type="protein sequence ID" value="KJY28893"/>
        <property type="gene ID" value="VR44_24230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.826"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY28893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="19008" checksum="464F4056D32AEA22" modified="2015-06-24" version="1">MSKHTLSVLVENTPGILARIAALFSRRGFNIDSLAVGVTEHPDISRITIVVNVEDLPLEQVTKQLNKLVNVLKIVELEPSNAIERELVLVKVRADNETRSQIVEIVQLFRAKTVDVSPEAVTIEATGGSDKLSAMLKMLEPFGIKELVQSGTIAIGRGGRSITDRSLRSLERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5A6</accession>
    <name>A0A0F4J5A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28101">
        <property type="protein sequence ID" value="KJY28101"/>
        <property type="gene ID" value="VR44_26075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1370"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="141"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="31928" checksum="2347AB1DCBB45DE7" modified="2015-06-24" version="1">MTGTRHHHEELFSVSQTVDRLRALAPELPEAQRALAVFILHDPPAAAARTILELAEAVGVSTGSITRLCRALGLPGYAQLRLALAASGAERDARGTWRADIGTDIGEHDSLARVAASVAATVSDVVTRTVEGLDLAVVEEVAARIAAARRTELFGVGGSATMAAEFQQRLYRIGLPVWAWSDTHVALTGAAVLGRGDVALVLSHSGGTREPREVLAEAASRGATTVAVTNAPASPLALHAELVLTTSVRAAGLRAEAVLARHAQMAVLDVLYVAVAQRTYDRTTQAMAATDEAVRPYRRDDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6C8</accession>
    <name>A0A0F4J6C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable subtilase-type protease inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sti</name>
        <name evidence="11" type="ORF">VR44_25295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Strong inhibitor of bacterial serine proteases such as subtilisin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28451">
        <property type="protein sequence ID" value="KJY28451"/>
        <property type="gene ID" value="VR44_25295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1156"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00778">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8 9" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8 9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008987401" description="Probable subtilase-type protease inhibitor" evidence="8">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="8">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="14675" checksum="919822B169F464C9" modified="2015-06-24" version="1" precursor="true">MRSITRCLGLASGAMALTALTALAGTGAADAAPTGTQTLYAPSALVVSVTAGQDAAAGTVLRAVTLVCAPRPGGTHPSPAAACAELKANAASLDALAAPRPDSACTREWNPVTVTADGVWQGRRMSWTYTFGNPCGLRSSSGVLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W3</accession>
    <name>A0A0F4J6W3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein VR44_22780</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_22780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000638">
        <property type="protein sequence ID" value="KJY29498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949435.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000638.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29498">
        <property type="protein sequence ID" value="KJY29498"/>
        <property type="gene ID" value="VR44_22780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.488"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11583" checksum="8AAB756E8B968BC6" modified="2015-06-24" version="1">MLVVRSVALFAAAALFEIGGAWLVWQGVREHRGWAWIGAGVIALGVYGFVATLQEDANFGRILAAYGGVFVAGSLAWGMVLDGYRPDRADVIGALICLVGVAVIMYGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J706</accession>
    <name>A0A0F4J706_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000707">
        <property type="protein sequence ID" value="KJY28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949793.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000707.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28716">
        <property type="protein sequence ID" value="KJY28716"/>
        <property type="gene ID" value="VR44_24750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.949"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="19770" checksum="741EDF3E40241C95" modified="2015-06-24" version="1">MDTTKTADPTAPEADAAEDKPDTGTPAEPEAPTDAPAPATDASDAVADEEPEDLDEADTFPERPTGVGSAASAVTAAGLGLVALSGSWVARVIGERQTLIGQIESANATTAKEKIAALYGDAWHMTALVNGLLSALALLLAAVVLAAPAFGAPGRAHPTWVRSVSWAAVALGVLGVLLFALMYFDLLVPLPTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7W0</accession>
    <name>A0A0F4J7W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949256.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29853">
        <property type="protein sequence ID" value="KJY29853"/>
        <property type="gene ID" value="VR44_21820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.243"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="89"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="19196" checksum="3D6BC3F3AE2AEEF9" modified="2015-06-24" version="1">MSLRHALLGLLSERPASGYDLLKRFETSLANVWPATQSQMYGELTKLAAAGLISVSAEGPRGRKEYTLTDEGLAELRHWLTETKPQRNTRSDILLRVFFLGVLPPEQASAYLTGLMELSEQEYEDLRALEQSIDWGEDTLSVHGRIALEYGLRFNAMRRDWARWAAAQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J868</accession>
    <name>A0A0F4J868_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-glucosamine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949020.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1093"/>
    <dbReference type="EnsemblBacteria" id="KJY30410">
        <property type="protein sequence ID" value="KJY30410"/>
        <property type="gene ID" value="VR44_20570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8825"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="308"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="43669" checksum="2C48D7289F106A8D" modified="2015-06-24" version="1">MPADLAVIGLGHLGLPLAQAAVAAGIETVGYDSGPATDSPLTAAEIRRMSAAGFRVTTNPAELGRVRTAVICAPTQLGADRALDLGAVGAAGRTLAARLRPHTTVILESAAHPGVTEDYLRPILEEGSGLRAGRDFHLAYSPSRLDPGNRTHTIANTPKVIGGLTPACTESAHAFYARLTEKVVRARGLREAETVQLLETNYRHVNIALMNEMAVLCHDLGVDLWDVIRCAETKPYGFQAFRPGPGVGGHGVPLDPNYLPHTTRTPGHPLRMVGLAQEINGRMPQYVIQRCATLLNEHGKSARGARVLLLGVTYKPDLADQEGSPAGEIASRLLDLGALISYHDPYISGWRVRDQPVPRADSLYEAAANADLTILLQHHRTYDMQGLAVKAQLLLDTRGASPAGAAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8I6</accession>
    <name>A0A0F4J8I6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_19760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042820311.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000545.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3125"/>
    <dbReference type="EnsemblBacteria" id="KJY30707">
        <property type="protein sequence ID" value="KJY30707"/>
        <property type="gene ID" value="VR44_19760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8571"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="30"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="37243" checksum="115CB10077BA40C3" modified="2015-06-24" version="1">MSSNRTHQWRGIIEEYRDRLPVTETTPVVTLREGGTPLVPAQVLSERTGCEVHLKVEGANPTGSFKDRGMTMAITKAKEDGAKAVICASTGNTSASAAAYAVRAGMVSAVLVPRGKIALGKMGQALVHGAKILQVDGNFDDCLDLARALSDNYPVALVNSVNPVRIEGQKTAAFEIVDALGDAPDIHVLPVGNAGNITAYWKGFKEYKADGLASRTPRVWGFQASGSAPIVRGEVVKEPHTIATAIRIGNPASWDYALAAKEESGGFIDEVTDRQILAAYRLLASQEGVFVEPASAASVAGLLKAAELGLVDPGQKIVCTVTGNGLKDPDWAVAGAPQPVTVPVDAEAAAVRLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8M9</accession>
    <name>A0A0F4J8M9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">VR44_20190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000557">
        <property type="protein sequence ID" value="KJY30545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948953.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000557.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5308"/>
    <dbReference type="EnsemblBacteria" id="KJY30545">
        <property type="protein sequence ID" value="KJY30545"/>
        <property type="gene ID" value="VR44_20190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8743"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="21789" checksum="1852FD4DF0BD2900" modified="2015-06-24" version="1">MLKVGLTGGIGAGKSEVSRLLAGYGAVVVDADRIAREVVEPGTPGLAAVVEAFGESVLTDGGALDRPKLGAIVFADPGKLQTLNAIVHPLVGARSAELEAAAGPDAIVVHDVPLLTENGLAPLYDLVVVVDAAPGTQLSRLTALRGMTEEEARARMAAQATREQRLAVATLVIDNDGPLEALEPQVRAVWDQLRQRAAARTGTTRPAAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8X2</accession>
    <name>A0A0F4J8X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system, antitoxin component, Xre domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949478.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29406">
        <property type="protein sequence ID" value="KJY29406"/>
        <property type="gene ID" value="VR44_23015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.540"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="9903" checksum="2962FC167AD3810C" modified="2015-06-24" version="1">MPPRLLGIGPAGRAAAQAIERTRVARGYSQRQLAARVTALGRPMTFTALSRIERTVRRCDIDDFVAIAAALGAPPHALLAAASSRPESLRVGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9C5</accession>
    <name>A0A0F4J9C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949394.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000042_gene5990"/>
    <dbReference type="EnsemblBacteria" id="KJY29561">
        <property type="protein sequence ID" value="KJY29561"/>
        <property type="gene ID" value="VR44_22550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.400"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="485" mass="53628" checksum="BF6F1994D4291D4B" modified="2015-06-24" version="1">MAYDDLRSLLRALEREGDLKRIKAEVDPYLEVGEIVDRVNKAGGPALLFENVKGSAMPLAMNVFGTDRRLLKALGLKSYGEISEKIGGLLKPELPQGFIGVREAFGKLGSMVHVPPKKVKGESAPVQEVVLTGDDVDLDQLPALFTWPKDGGSFFNLGLTHTKHPETGVRNLGLYRLQRHDKRTIGMHWQIHKDSRNHYAVAAARGERLPVAIAFGCPPAVTYASTAPLPGDIDEYLFAGFVAGKRIEMVDCKTVPLQVPANAEVVIEGWLEPGEMLPEGPFGDHTGFYTPQEPFPALKIDCVTMRKRPLLQSIVVGRPPTEDGPLGRATERFFLPLLKIIVPDIVDYHLPESGGFHNCAIVSIDKKYPKHAQKVMHAIWGAHMMSLTKLIIVVDKDCDVHDLHEVSWRALGNTDYSRDLTVVEGPVDHLDHASYQQFWGGKAGIDATKKLPEEGYTRDGGWPDMVESDPATAALVDRRWKEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAH3</accession>
    <name>A0A0F4JAH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000540">
        <property type="protein sequence ID" value="KJY30753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30753">
        <property type="protein sequence ID" value="KJY30753"/>
        <property type="gene ID" value="VR44_19555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8522"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="890" mass="92444" checksum="AC5441A9F89FD892" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB88</accession>
    <name>A0A0F4JB88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000524">
        <property type="protein sequence ID" value="KJY31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31003">
        <property type="protein sequence ID" value="KJY31003"/>
        <property type="gene ID" value="VR44_19110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="9367" checksum="B5B080F32115A317" modified="2015-06-24" version="1">MTGFTAGASDCEGEAEAEADGDEDSDGDGEAVPGLSSCLDADAEGEATGADGAAGAEPECCGPHAVAAKATAVARPSVRMMALCRCIAVPPDSSSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBM9</accession>
    <name>A0A0F4JBM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_18775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000514">
        <property type="protein sequence ID" value="KJY31143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948692.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4128"/>
    <dbReference type="EnsemblBacteria" id="KJY31143">
        <property type="protein sequence ID" value="KJY31143"/>
        <property type="gene ID" value="VR44_18775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8366"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23588" checksum="C54EEA4E9133FE8F" modified="2015-06-24" version="1">MRVAIAGAGAVGRSIAGELLENGHEVLLVDKAPTAISVERVPQAEWLLADACEITSLDEAALQRCNVVIAATGDDKVNLVVSLLAKTEYGVPRVVARVNNPKNEWLFNESWGVDVAVSTPRLMSALVEEAVSVGDLVRLLRFSHGDANLVELTLPADSSVAGTQISEINWPEDTSLVTIIRGNRVLTPHGEETLEPGDELLFVAAQAREGQLEDLLQAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC17</accession>
    <name>A0A0F4JC17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31907">
        <property type="protein sequence ID" value="KJY31907"/>
        <property type="gene ID" value="VR44_17220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7977"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="14405" checksum="A36204FDC541EF43" modified="2015-06-24" version="1" fragment="single">SLERRLAEAGVGLGAADRATTGVVLASAGSSDPEAIAVIAEIAREWRLTGWCAVRPAFASAALPRTEDAVRALRAEGVRRVVVAPYVIAPGRLPDRIVTGAEAAGADAVAEVLGSAPELAALLLRRYDETAGAGPALPALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC18</accession>
    <name>A0A0F4JC18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_18455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000502">
        <property type="protein sequence ID" value="KJY31288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31288">
        <property type="protein sequence ID" value="KJY31288"/>
        <property type="gene ID" value="VR44_18455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="123"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="33947" checksum="598A007A52A2FFB2" modified="2015-06-24" version="1" fragment="single">MTNPITTLLVANRGEIAVRIFRTARALGLATVAVHSDPDADALHVRSADTAVRLPGAAPADTYLRAGLLIEAARAAGADAVHPGYGFLSENADFARRVEAAGLTWIGPPPAAIEAMASKTRAKDLMRAAGVPLLESVDPATATAADLPLLLKAAAGGGGRGMRVVRDLDSLKESLDAAVAEALSAFGDGEVFAEPYVEHGRHVEVQVLADAHGTVWALGTRDCSLQRRHQKVIEEAPAPALTDELRERLHAAAVAAARAVSYRGAGTVEFLVGADGRPYFLEMNTRLQVEHPVTEAVFGLDLVALQLRIAEGEPLPPTPPDPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC28</accession>
    <name>A0A0F4JC28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948957.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6960"/>
    <dbReference type="EnsemblBacteria" id="KJY30511">
        <property type="protein sequence ID" value="KJY30511"/>
        <property type="gene ID" value="VR44_20220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22106" checksum="1A7B286627839369" modified="2015-06-24" version="1" fragment="single">MPKNQNTFSSLAALRRRVAGRAVHAGWRWMQRAGAVTAENPGRLRFGAIGDGTRLAFPQGTVFGEPWIRMGGHCIIAEQVTLTAGMMPDLDLGPDPVLVLGNGVVLGRGSHVIADARITIGDDTFCGPGVYITSTNHSYDDPHQPVGKQWPRSAPVEIGPGCWLGTGAVILPGAKLGRNVVVAAGAVVRGEVPDHAVVAGAPAKVVRRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC79</accession>
    <name>A0A0F4JC79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000464">
        <property type="protein sequence ID" value="KJY31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948424.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000464.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31815">
        <property type="protein sequence ID" value="KJY31815"/>
        <property type="gene ID" value="VR44_17380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8012"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="44504" checksum="86BDC04AF868BE22" modified="2015-06-24" version="1">MAEPGHTSTDDTPLALHPLVYLQDGDEVTIGRRDTESYAIFPPDGAELVRRLQEGATPAQAADWYEAEYGERADVADVVEALHELGFVRTEGEPEPVAGPVRWQRLGRAAFSPAAWTAYGLIVAWAAVSVIRDPGLLPTPGDLVFSHYYAVITLVLFVVAVPLIAVHEIFHALAGRRLGIRSRTRMSYRFYFLVVETSLDGLAGVERRKRYLPILAGMVADVVLIALAVITAGLVHGLTGRVCLAIAFTTFIRLLWQFFLYLRTDIYVLITTVLGCVDLHTTAVRMLANRVNRLLGRTDRLTDESLWHPVDRRAARWYSWLLPIGYAISLTTFLWGVGPVFLAMTSASLDRFGTGHSTWVQLTDAAVFLVLTFGQIAFALWLAARERLRSRRARLHHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCI0</accession>
    <name>A0A0F4JCI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948317.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000445.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32057">
        <property type="protein sequence ID" value="KJY32057"/>
        <property type="gene ID" value="VR44_16795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7794"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="370" mass="39725" checksum="DBEA6CA7F5499462" modified="2015-06-24" version="1">MSLTGTPLFATVIGLTLIAVVLPLTVWGKVRGPAAARLATRGLMVLFAQVTAVALVFVAVNRDMNFYASWGDLMGTGSYVQSAPDLGADGMGGKKAEQVRQEPKVRQDFEPVDGLGGRVKKTELEGKISGVKGDVMVWLPPQYDDPAYKDKKFPVVELIPGIPGTGKSWFQGLKAHEVLEPLMKEGKVQPFILVSPRAMLLGNADTGCANLPGKVNADSWFSVDVRKMVTDNFRASDEPRTWGVAGYSAGAYCAAKLAILHPDRYGAAVSLSGYNDPGQEPTSLVAKDPELRRTHNLKELLKAQPAPPAVALWMSGAEQDGYLSGMDLKGLAQNPTTVHAEKVTGGHNLESWSKQLPQTFGWLSQTVKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCU2</accession>
    <name>A0A0F4JCU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ethanolamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948821.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30801">
        <property type="protein sequence ID" value="KJY30801"/>
        <property type="gene ID" value="VR44_19455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8500"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004757">
        <property type="entry name" value="EtNH_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00908">
        <property type="entry name" value="2A0305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="485" mass="50340" checksum="1D75E25372140148" modified="2015-06-24" version="1">MAEDLSTAPASPAVGDTDAEYLQRRTLRRGSAGWLLLTGLGVAYVVSGDFSGWNVGLSKGGFGGLAVATVLMGAMYACLVFSLAELSTILPTAGGGYGFARRALGPWGGFLTGTAILIEYVLAPAAIVIFIGDYVESLGLFGLTSSWPVYLGCFVLFIGVHLWGVGEALRFSLVVTAVAVAALLIFAVGALTDFDAGSLDNVPVDPGAFGSNSWLPFGVLGIWAAFPFGMWFFLGVEGVPLAAEEAKDPVRSMPRALAISMGILALLALVTFFAATGAQGADAVKSAGNPLVVALEGDGGPTALSRFVNYAGLAGLVASFFSLIYAGSRQLFALSRAGYLPRFLSLTSKRKAPYLGLVIPGAIGFALAAATGNGARMLNIAVFGATISYALMALSHIVLRRREPGLERPYRTPGGVLTSSVAFVLALSALVATFLVDIDAALIALAVYAVALAYFAFYSRHRLVASAPEEEFAALAEAEAELTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD90</accession>
    <name>A0A0F4JD90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_17475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="JZWV01000467">
        <property type="protein sequence ID" value="KJY31784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948441.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000467.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000070_gene5902"/>
    <dbReference type="EnsemblBacteria" id="KJY31784">
        <property type="protein sequence ID" value="KJY31784"/>
        <property type="gene ID" value="VR44_17475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8057"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="311"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY31784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="428" mass="45849" checksum="95AE13286B6DBCB9" modified="2015-06-24" version="1">MAERRIAVFGAGYIGLVTGACLAELGHHVTVRDINPERVRILRAGDVPIHEPGLGDMIARNKERLTFTEDLTEAVNGAEIAYVCVDTPPSASGDADLSRVWAVVRSLADAGDLKAVVMKSTVPVGTGARARALLDEIGLSHVGYVSNPEFTAEGRAIQDFMAPDRIVIGQDNDTAGALVTALHTGINAPVATMDVKSAEMVKLAANALLATKISFANEIATLCENTGANVTEVLQAVGMDHRLGAHFLRPGIGWGGSCFPKDSEALRQMASNTGFHPQLLTAVINVNNIQKRRAVQHLKDELGDLAGKRIALLGMAFKPGTDDMREAPSTVLASRLLAEGAQVRSWDPLARPAAGEPWDSATRYPTPMQALGGADAAVLVTEWPELAEIDWTEAHRVMRTPVMFDGRNLLDPARLREMGFRYTSVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDF8</accession>
    <name>A0A0F4JDF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000426">
        <property type="protein sequence ID" value="KJY32240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948228.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000426.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32240">
        <property type="protein sequence ID" value="KJY32240"/>
        <property type="gene ID" value="VR44_16325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7721"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="30636" checksum="26EC979E770848B2" modified="2015-06-24" version="1" fragment="single">RLELAGGAAGRRALVLRSFVRPFYLRHAEGLLTREAEILRLLGGTDVPAAALVAVDATAQYCDHPSLLMSLLPGTVRLDGDEEDRRAGLMARQLLAVHRLEVSEGDRPRAYQAWTSAEGVTPPERTRRPELWRRAVDVIRREPPRYRACFLHRDFHPGNVLFEGAGEELRISGVVDWVETSWGPADLDVAHCSTSLALLHGVPAGMRFADRYLAAGGTLTEDPADHLYWRLLDALAFAPDAEKVGVPWRALGRTDLTPAVLADRLEGYLEALFARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDN9</accession>
    <name>A0A0F4JDN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000412">
        <property type="protein sequence ID" value="KJY32447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32447">
        <property type="protein sequence ID" value="KJY32447"/>
        <property type="gene ID" value="VR44_15970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7613"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470619" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12012" checksum="89601225A0FF58FF" modified="2015-06-24" version="1">MIKFAAAGIAAASLVALSAGAASAASLGGDAFAGNCHAYILPYSDMYAYGHVDGPANECKVDLWQVNTQTGGRTHTGWGGGANTWPEYHNDGVHKLYVEVLDINTNQVGWGPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF45</accession>
    <name>A0A0F4JF45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000481">
        <property type="protein sequence ID" value="KJY31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948505.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000481.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31596">
        <property type="protein sequence ID" value="KJY31596"/>
        <property type="gene ID" value="VR44_17815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8106"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="147"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="28156" checksum="59CFFAFE5A826AFB" modified="2015-06-24" version="1">MNTAGQLDHRAAVAAEAARFADLVRGADMTAPVPTCPGWDLTDLVRHAGSVHRWFTVLLRRRIQAPPTSREVDLRLPERADGYADWLAEGAAEAAEVFAETDLDAPMWVWGADGHARFWVRRMAFETLLHRVDAERALGLPSAVDRELARDGVDEFLVNLPYATLFAPKVANLRGADRTLRFECADTDGSWLVRLRPDGFGLVTDGTAADSPADAVVRAPAADLLLFLYGRLDRSAASVETGGDEELLDLWTANSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFS0</accession>
    <name>A0A0F4JFS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_15530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32649">
        <property type="protein sequence ID" value="KJY32649"/>
        <property type="gene ID" value="VR44_15530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7506"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY32649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="420" mass="44415" checksum="2D8BF01A991AB843" modified="2015-06-24" version="1">MFSSLKIRNYRLFAAGQVVSNTGTWMQRIAQDWLVLSLTGSASAVGVTIALQFLPMLLFGLYGGVLADRLPKRPLLIATQTAMGLTGIALAALTLAGNVQVWHVYLAAFLLGLVTVVDNPARQTFVSEMVGPAQVANAVSLNSANFQSARLVGPAIAGVLITAVGSGWAFLLNGLSFAAPIAALLMMRTRELYRVEPQPRAKGQLREGLRYVAGRPELVWPIVLVGFIGTFGFNFPIWLSAFVDDVFHGDAGTYGVFNTLIAAGSLAGALLAARRGNTRLRLLVTAAVLFSVLLLVTAFAPGLWLFAALLVPVGMFGLTVNVVANSSVQMATDPEMRGRVMALYMMVFTGGTPVGAPLVGWITDTYGARLGMAAGGLVSLAAAVAVGLILRRVGNLRLRVGRHGLRFVPATPRRELAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHC6</accession>
    <name>A0A0F4JHC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947690.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33752">
        <property type="protein sequence ID" value="KJY33752"/>
        <property type="gene ID" value="VR44_13380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6912"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471048" evidence="1">
        <location>
            <begin position="36"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="447" mass="48037" checksum="C19C415972ED5E08" modified="2015-06-24" version="1">MPTAGRPATAATALAALSALVLLATACTGQGAATASDDPKADTTLTFWHGWSAPGEVKAIEENIARFEKAHPNIKVDVTGNMTDDKINQALRAGGGKAPDVVSSFSTDSVGKFCHSGAFADLNPFLKKSGIDKAKVFPPTLLEYTQFKGDQCTLPLLSDAYGLVYNKTAFAAAGITEPPRTWSQFTEDARKLTKPRGDSYEQLGVMPTFHGYETTPMRLAAQWSPSYFAADGSSALAEDPAFAKMLTAQKDLVDQLGGYERLERFRAGFGDEWSAEHPFHKGLVAMQIDGEWRPEMAREAGVGFEIGTAPLPVPDEQAADYGKGYLSGTVMGISAASRKQNAAWELVRYMTTDTEAVVSFANAIHNVPSTFAALESPQLKVTPEFRTFLDIARHPKSGTTPARADGGTYQLTFQDFAYRTEKGEVPDLQAGLAATARQIDTDIAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHR1</accession>
    <name>A0A0F4JHR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">VR44_14065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947818.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2572"/>
    <dbReference type="EnsemblBacteria" id="KJY33354">
        <property type="protein sequence ID" value="KJY33354"/>
        <property type="gene ID" value="VR44_14065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7126"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="38931" checksum="21673F6162A4763F" modified="2015-06-24" version="1">MSAARQGVVDARRIVVKVGSSSLTTAAGGLDADRVDALVDVLAKARSGGEKEIVLVSSGAIAAGLSPLGLARRPKDLARQQAAASVGQGLLVARYTASFARYGVRVGQVLLTTDDTSRRAHYRNAFNTLDQLLAMGALPVVNENDTVATDEIRFGDNDRLAALVAHLVRADLLVLLSDVDGLYDGDPSLPGTTRIEEVRGPEDIAHVSIGSAGKAGVGTGGMVTKVEAARIAAAAGVPVVLTSASRAADALAGRETGTLFHPTGRRSADRLLWLQHASTPQGHLVLDDGAVRAVTERGSSLLAAGIAAVEGDFVAGDPVELRSAEGAAVARGLVNFDAKELPQLLGRSTRELARELGPAYEREVVHRDDLVLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIC7</accession>
    <name>A0A0F4JIC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34102">
        <property type="protein sequence ID" value="KJY34102"/>
        <property type="gene ID" value="VR44_12630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6592"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="290" mass="30728" checksum="1C1F3145D1BC1B2F" modified="2015-06-24" version="1">MDDVELRHLRALDAVAEAGTITAAAASLHMTQPALSRTLAQLEARVGVRLVDRSSRHLALTGPGTTLLEHGRAILSHLDAALADTRAESRPLRLGYTCAVLGQQTVPLLRAWRRTHPGTPLDVVRRDNATAGLATGETDVAVLRTLPEDPRIRSEALYTEDRVAALPDDHPLAGRDSVLLAELTAGPPLPLPLAMWPEAGTASPELWPPQARPARTVEVGNVDEWLNLIATGGAFGVASAGTAESHGHPGVRFLPVSDAPPATVYVSYPHHPTHPGTAEFLTAVRDTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIQ3</accession>
    <name>A0A0F4JIQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947713.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000345.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3029"/>
    <dbReference type="EnsemblBacteria" id="KJY33689">
        <property type="protein sequence ID" value="KJY33689"/>
        <property type="gene ID" value="VR44_13500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6951"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471080" evidence="4">
        <location>
            <begin position="41"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="75"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="260"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="415" mass="43336" checksum="19B21A54A46274FC" modified="2015-06-24" version="1">MGRTRVNVQPIRGRVRTGLPALLLGAALLLTTACSNGGGAAGGGGDNGKAGGGNAAKANTEASKAVVSVKPDDGAKEVATSGVLKVTSTGGKLTTVTVADTKGNAVEGKLTPDGAAWEPARNLAAATEYKVHAVAKDEAGRESAKDATFTTLTPQNTFVGHYTPEDGSTVGVGMPVSINFTRGITNTEAVEKAITVTAEPSVPIEGHWFGNDRLDFRPEKYWAAGTKVTVKLALDGVEGRPGVYGKQTRTVTFTVGRSQVSTVDATAKTMEVVRDGQVIKNLPITAGAPATTTYNGQMVISEKYKVTRMNGATVGFGGEYDISDVPHAMRLSNSGTFVHGNYWASSSTFGSENVSHGCVGLEDERGAGDPNTPAAWFFNESLIGDVVIVKNSKDKQIAPDNGLNGWNMDWAEWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJG5</accession>
    <name>A0A0F4JJG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Class IV aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_14520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000374">
        <property type="protein sequence ID" value="KJY33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947898.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000374.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33111">
        <property type="protein sequence ID" value="KJY33111"/>
        <property type="gene ID" value="VR44_14520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7164"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28809" checksum="23D872054A18EC92" modified="2015-06-24" version="1">MRIWLDGALRDADDAKVSVLDPGPALGYGVFETLKAEHGTPFALTRHLERLTRSARGVGLPDPDLDEVRRACAAVLEANPMPLGRLRITYTGGLSPLGSDRGGTGPTLVAAVGAATRRPDTTAVITVPWVRNERSPLTGLKSTSYAENVVALARANRAGASEALFANTVGQLCEGAVSNVFVVLDGELHTPPVASGCLAGITRALALEWTGAHETDLPFDVLERSEEVFLTSTLRDVQAVHRVDGRTLAAAPGPVTANAMRVFEERAASDIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJK1</accession>
    <name>A0A0F4JJK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000323">
        <property type="protein sequence ID" value="KJY33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947597.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000323.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33979">
        <property type="protein sequence ID" value="KJY33979"/>
        <property type="gene ID" value="VR44_12880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6672"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="126"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="33442" checksum="2AF744368A30EC82" modified="2015-06-24" version="1">MTESRPHALFSFGTLRDAHVQTTLFGRTVPSSPASLVGYTTRPLKITDPDVIAASGLDVHLTLECRLGSVVEGAVLRLTDGELAAADAYEVDDYVRRRVLLSSGESAWAYLDADPLRSAARIVIAGDSIAYGRCDPRGGWAARLAARHIGANEHDHRVFNLAVPGNTLAGVAEQTPALLAARRPDTLLIAAGINDSAVPLASPQPDPDGLTHLADALASLAATAREHNARLVVVGPVWLDESRLADYEGLRFTESRALALRETLRAWCTEHHIDHIDLWAPLHGRPELLTDGIHPNPEGHEALYHHLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMQ0</accession>
    <name>A0A0F4JMQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35642">
        <property type="protein sequence ID" value="KJY35642"/>
        <property type="gene ID" value="VR44_09660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5380"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="68" mass="7466" checksum="D1FF5E67B7586E87" modified="2015-06-24" version="1">MKLWTQLRVTGTRYRPVNIWRDPDAAAFVRSVNDGNETVPTVRVVSPSGTESVLTNPSLAEVRQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN72</accession>
    <name>A0A0F4JN72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947006.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35640">
        <property type="protein sequence ID" value="KJY35640"/>
        <property type="gene ID" value="VR44_09625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5373"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24136" checksum="E97D12324C03067F" modified="2015-06-24" version="1">MPAAATPPAIQAPTAAERVYRHVKQGVLDRRYEGGVLLTEGELAVAVGVSRTPVREALLRLETEGLLKLYPKKGALVLPVSAQEIADVVETRLLVEEFTVRRAVPAPPALLERLTDLLAELRRHAAAGDLAEMMAADRCFHAEIVRNAGNQILSRLYDQLRDRQLRMGVALLHAHPDRVERTLAEHAEILDALRAGDREAAAAAVRGHIGRVEALVRGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNL3</accession>
    <name>A0A0F4JNL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_10320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000227">
        <property type="protein sequence ID" value="KJY35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947122.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000227.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35358">
        <property type="protein sequence ID" value="KJY35358"/>
        <property type="gene ID" value="VR44_10320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5933"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="28646" checksum="6B58724DB261A795" modified="2015-06-24" version="1">MTTTTLPLRARNRYVGGLLTVRGITGLALVSGLALAALLAPLLTSADPLAQSGDALLGPSSRHPFGTDDLGRDLFSRVLHGIRADLAIGLTAVPLAAAAGCALALLSVSSRAADAAVQRAFDLVLAFPGLILALTVTAIWGPGRLPVVAVIALAETPAFGRLLRGGILVQREREYALAAHVGGAGRLRVLFRHVLPNAIDPIVVQIATALSIAVFIEGAMSFIGVGIRPPEPSLGSILSQSTGYMGTHPSFAVAPLVAVTALVIGFTLVGEALNRGIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNZ2</accession>
    <name>A0A0F4JNZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36087">
        <property type="protein sequence ID" value="KJY36087"/>
        <property type="gene ID" value="VR44_08555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4853"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="40517" checksum="2BD4083645840F12" modified="2015-06-24" version="1">MTANDHAPALPPVRPAFDGVTWKEIAYLLTNLPVALIGFVYTVVMLATAGGLAVTVVGLPVLVVGLYLSRLLGKLERGRARALLGVRVDEPSALPGPSRSGGFFPWLWAGIKDPVAWRTVLFELVRLPWGVLTFSIALVGLFVLWPVLPYVVRLLANLDRLMVRGLLSPSDGLERRIAELESGRGVVVDTAAADLRRIERDLHDGAQARLVALAMGLGLAKEKLLEDPEGAAAMVDEAHGEVKLALQELRDLARGIHPAVLTDRGLDAALSAVAARCLVPVKVSVRLEERPAEAIEGIAYFVVSELLQNVSKHAQARGAGVEVWREGARLLIRVADDGVSGGSGLAGLAERVRAVDGGFVVESAVGAGTVVVAELPWRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP68</accession>
    <name>A0A0F4JP68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4840"/>
    <dbReference type="EnsemblBacteria" id="KJY35639">
        <property type="protein sequence ID" value="KJY35639"/>
        <property type="gene ID" value="VR44_09705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5389"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="24549" checksum="5140D499DAF4498B" modified="2015-06-24" version="1" fragment="single">RIPVKGVRKVTAQAMVGSAFTAPHVTEFITLDVTRTMKLVQELKDDPDLAGLRINPLLLIAKAVLVAIRRNPDVNASWDEAAQEIVLKHYVNLGIAAATPRGLIVPNIKDAHAKTLAELSASLSDLVATAREGKTSPSDMQNGTITITNVGVFGVDTGTPILNPGESAILAVGAIKLQPWVHKGKVKPRQVTTLALSFDHRLIDGELGSKFLADIAAVLEHPRRLVTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPD0</accession>
    <name>A0A0F4JPD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_09750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947018.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35608">
        <property type="protein sequence ID" value="KJY35608"/>
        <property type="gene ID" value="VR44_09750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5450"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="25040" checksum="6CDFC16709264F5C" modified="2015-06-24" version="1">MPRVLLIEDDPSIREGVALGLRRRGHEVRAAGTGEEGLALTDAFDPELVLLDLMLPGINGVQVCRRIRETSLVPIIMLTARGDDFDIVVGLEAGADDYIVKPARTAIIEARVRAVLRRRPDTPGRHGVEHHGELAIDRAGLTVAKNGERLALAPSEIKLLLHLSAAPEQVFSRQQLLESVWEHSYHADARLVDACVRRLRHKIEDPAHGPRYIQTVRGFGYRFGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPF4</accession>
    <name>A0A0F4JPF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946750.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36252">
        <property type="protein sequence ID" value="KJY36252"/>
        <property type="gene ID" value="VR44_08255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4550"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15522" checksum="94021387A5522483" modified="2015-06-24" version="1">MERAIELSRKCPPAEGAFSVGAIIVSADGEELAHGYSRETDAHVHAEESALSKLPADDPRLAGATIYSTLEPCSERRSRPLTCTQLILRSPIRRVVIAWREPSLLVADCVGVETLREAGTEVLELLELADMARAVNSHLFGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR10</accession>
    <name>A0A0F4JR10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946525.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36797">
        <property type="protein sequence ID" value="KJY36797"/>
        <property type="gene ID" value="VR44_07120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3767"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SCP_3" evidence="2">
        <location>
            <begin position="169"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="27523" checksum="582EF99E8B0924A9" modified="2015-06-24" version="1">MPPAKKKTRTYDHVKVRAAVIAQFGHVAAAVRDLGDEELARPSGVGEWSVGDLAGHIAWIADSLAGGLARPPAAVAELSAVEWPFATASLAGKISEAARETLGGAPVAELFERAGARMAEALEANPGSRVMHLWIGDMTLADFLVTRTVELVVHTDDLNRAAGLDIPVERQALATCTRLLADALAVKAPGGSVEVRIPPFAVVQCVEGPRHTRGTPPNVVETDPLTWLRLATGRTGWAEALDAAAVSASGERADLSGLLPLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR71</accession>
    <name>A0A0F4JR71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_07405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946574.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36685">
        <property type="protein sequence ID" value="KJY36685"/>
        <property type="gene ID" value="VR44_07405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3954"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY36685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23082" checksum="29FB99764CE4727E" modified="2015-06-24" version="1">MSVTEQPAPQPGQGPAGDADGDAAAAQLRDRISADSLTTRRDYLRIVATVSGGLAIGGVGVAAGILHRHGDSEHLPEPKKVTDALAPGQSVAFRFPGDEDRALAVRLADGSLVGYSAVCTHLACAVLWREDRGSEGELYCPCHEGVFDARTGEVTAGPPPRPLPRIFLTERADGSVWAIATARSGETAKDALCRQFGDSRPEAARRLGCPGTAGATESRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRH4</accession>
    <name>A0A0F4JRH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000215">
        <property type="protein sequence ID" value="KJY35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947061.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000215.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35531">
        <property type="protein sequence ID" value="KJY35531"/>
        <property type="gene ID" value="VR44_09990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="23634" checksum="CCBFA96CD753F616" modified="2015-06-24" version="1">MPETNAEDPQRPATPEQASRPEQPAVKTLDARSLRGLAHPLRMRMLAALRHEGPATASQLAEQLGESSGATSYHLRQLAAHGFVEDAPGHGKGRERWWRAVHQGTAFDETLMYDEADPETRGAADAFLHEIATIHTQELHTWLGDSHNWPREWRSSTDMSDFTLHLTPAQATELIHKMHDLVNSYRDLPQAENTETVRLHTHAFPRRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRI2</accession>
    <name>A0A0F4JRI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946533.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36805">
        <property type="protein sequence ID" value="KJY36805"/>
        <property type="gene ID" value="VR44_07180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3780"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="69"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="25806" checksum="4217C0EE581E7B2A" modified="2015-06-24" version="1">MSTSRKSTRKPLLYAAGVALAALTLGIVSWQATAPAEKHRETSSAASAEATPGSDPAAELKALARREAGDKLAVGRTDAPVVLIEYSDFKCGYCAKFARDTEPELVKKYVADGTLRIEWRSFPIFGAESEAAAKAAWAAGQQDRFTAFHAAAYAEGAKAKGFGEDRLVELAREAGVPDLDRFKADMAGEQAAAALRRDREEGYRIGVQSTPSFLVNGQPIAGAQPLGAFTTAIARAEAQAKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS3</accession>
    <name>A0A0F4JRS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_PP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35646">
        <property type="protein sequence ID" value="KJY35646"/>
        <property type="gene ID" value="VR44_09515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5304"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_PP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="13005" checksum="C6A27198A60B9972" modified="2015-06-24" version="1">MSQTYETENGLVHMTRPDMAVLATAGLRERTRILEQYVREELGRILGIEPHLVDTTGRPMGCLGIGSISGIELQYRMEATLGVDVNLQRLLLANSAQELIDCLAGQLGPEAHLHGAAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRS5</accession>
    <name>A0A0F4JRS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946692.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000160.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36448">
        <property type="protein sequence ID" value="KJY36448"/>
        <property type="gene ID" value="VR44_08030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4432"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="312" mass="33364" checksum="CFE795EB169B58D3" modified="2015-06-24" version="1">MSTNVLRTADGWWVLRGDRAVPVATSAATTAELIADRAAVREAALSGDAGTPVADLVVLSPVTTPCRVVAQMVNYRSHARDSGFTGDIPPAFFRKASGSVSGPGEAIVRPSHVKFLDYEIELGLVMGAPLPVGTVVEERDLPTHVAGLVITNDVSAREVQLTKTQFYESKSYPTFTPTGPCLALLEPEDFAHLLDLRLRLSVNGELRQDRTLADMIVRPAQALTLLARFQTLDPGDLLLTGTPGGTALKAPPKAVEKIGALLPPAVKWKAFFKSQARNPHYLHTGDVITATISTADGRIDLGEQRTPVTDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS11</accession>
    <name>A0A0F4JS11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000203">
        <property type="protein sequence ID" value="KJY35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35741">
        <property type="protein sequence ID" value="KJY35741"/>
        <property type="gene ID" value="VR44_09320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5191"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11292" checksum="29B340F9FEFA0081" modified="2015-06-24" version="1" fragment="single">MDRTTRLYALVEELRAAAPRPRPVAALAARFEVSTRTVQRDLQALMDSGVPVRTTLGRGGGWTVDPAMTLPPVHFTADEAAALAAALATTGTPYAGAARTAYQKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS36</accession>
    <name>A0A0F4JS36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946468.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36980">
        <property type="protein sequence ID" value="KJY36980"/>
        <property type="gene ID" value="VR44_06800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3440"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470984" description="Alpha-L-arabinofuranosidase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="490" mass="52958" checksum="4FC0F1BBF3A4AE93" modified="2015-06-24" version="1">MRFRPPSPARLTRRLLALLAPLLLLAAFLGAQPAGAAPAVDPDASYVLVNRNSGKALDVYNLATGDGARITQWTRNDQNQQQWRFTDSGGGYYRITSRHSGKVLDVRDGSTANGAPVVQWTDVNGTNQQWRLADSPDGYVRLIARHSGKALEVQGGSTADNANVVQYDDWGGANQQWQLVRVGGGTSGTCALPSSYRWTSTGPLAQPKPGWASLKDFTVAPYNGRQLVYATTHDTGANWGSMNFGPFTDWPGMASAAQNGMSSSAVAPTLFHFAPKNIWVLAYQWGRTAFSYRTSTDPANPNGWSAEQELFSGSIAGTGTGPIDQTLIGDGTNMYLFFAGDNGKIYRASMPIGNFPGSFGTNSTVVMSDTRDNLFEAPQVYKLQGQNRYLMIVEAIGSQGRYFRSFTATSLDGAWTPQAATESNPFAGKANSGAGWTNDISHGELIRAGADQTFTVDPCHLQFLYQGRDPKSGGDYGLWPYRPGLLTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSF6</accession>
    <name>A0A0F4JSF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37100">
        <property type="protein sequence ID" value="KJY37100"/>
        <property type="gene ID" value="VR44_06550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3224"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="10552" checksum="0F62726A8FEEA7FA" modified="2015-06-24" version="1">MAERITSVRVAVLHAARKRGPAWWTVRDMHALCREAGSESTIQRHVRRLYFAGVLERRETHEAYFYRVAAVQPAAAKEYLKRVDEVAAVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSM3</accession>
    <name>A0A0F4JSM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000139">
        <property type="protein sequence ID" value="KJY36763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36763">
        <property type="protein sequence ID" value="KJY36763"/>
        <property type="gene ID" value="VR44_07275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3796"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="22723" checksum="B44C775F203ABD1C" modified="2015-06-24" version="1" fragment="single">PDPGPVPGMGPADRRAARGAPAPGVGADLSGGTASATLALLAAGLPGAPGTLPGSGSRLLAVTFNDLATPRGREGELESAHALAADPRLHHVVVAAAEEALPYADLDGPLTDEPGPCLVSAARDRRRLAAGSADHFTGHGARQVLDAHPARMADLLLDRRRRHLLRPVAALARSASEGPLLVPFSVYSAARRLARTPYRAGIEAAAARLREGGVATAVSGPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT84</accession>
    <name>A0A0F4JT84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_08425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000173">
        <property type="protein sequence ID" value="KJY36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946766.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000173.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36181">
        <property type="protein sequence ID" value="KJY36181"/>
        <property type="gene ID" value="VR44_08425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="33"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24863" checksum="2F9408D2E8172B52" modified="2015-06-24" version="1" fragment="single">MSTVTTTKPAAPRTAAAAPAEDGRIGLRGNLRHIGALVRRNALQIKQDPESMFDAVFMPIIFTLLFVFVFGGAISGKGNQEQYVNYVVPGLMAMMGMNIAMGVGTGVNDDFKKGVMDRFRSMPIARSSVLIAKIVVELGRMMVAIAILLAVGFMLGLSVHSVVDLLLAIGLSAVFGASLMWIFILLGLTMKTAQAVQGMAMLVLMPLQFGSSIFAKPTTMPGWLQAFTDYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTE7</accession>
    <name>A0A0F4JTE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37104">
        <property type="protein sequence ID" value="KJY37104"/>
        <property type="gene ID" value="VR44_06570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3230"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="20014" checksum="BD20390E641A2EEC" modified="2015-06-24" version="1">MDVNNGLLPADVISDYDVTRYVGKSGGTLSFDLVFDRTYEVADPSVVGEQSRKGVWADVHALYDLVGINEDRVEVSTSGSGGSDSGGLFGDIFDPLKDILNPGGGTSGPPDANSRYRGVMTIRPVYVVFTTDWYAQVGNTTGTARWYGYLNHLDVDFTHWSENMIPLRCTVGTTLQLLVEYGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTW2</accession>
    <name>A0A0F4JTW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946325.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37269">
        <property type="protein sequence ID" value="KJY37269"/>
        <property type="gene ID" value="VR44_06045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2545"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="31117" checksum="C265D551F7DA60EF" modified="2015-06-24" version="1">MTHPELRPRPPSPLVEAADERFGARGVRLLLKRDDLVHPELPGNKWRKLAPNLRAALEAGRDRLVTFGGAYSNHLRATAAAGRLLGLETVGIVRGDELADRPLNDSLTRCAADGMRLHFVTRSDYRRKAEPEVLARLLAAAGAADAYPVPEGGSNPLALTGCAELGRELRGAGDVVAVACGTGGTLAGLAAGLAPGQRALGVPVLAGGFLEPEIRSLQTAAFGAPTANWTLAEGHDHGGYARVPASLEAFAADFESRHGLPVERIYVAKLLQALTTLTQAGAFPRGTTLTAIVTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTW5</accession>
    <name>A0A0F4JTW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5791"/>
    <dbReference type="EnsemblBacteria" id="KJY37274">
        <property type="protein sequence ID" value="KJY37274"/>
        <property type="gene ID" value="VR44_06075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2551"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21816" checksum="E66AF13E68C7D596" modified="2015-06-24" version="1">MVLEIRQADQSDRDAVARLLDEAFRSDPVSSWVFPDPAHRAAVHGRFLGVFVDVALAEGRIDYAADGSAAALWLRVPAGEPEGEDEVPAKMRAVADPDNERCELVGRLTGAVHPTAEEHEYLLMIAVAPGRQGEGLGTELIRPVLERCDRDGVPAYLEASSERSMRLYERLGWEFTGEAVRLPDGPLMWPMWRKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU81</accession>
    <name>A0A0F4JU81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946153.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37725">
        <property type="protein sequence ID" value="KJY37725"/>
        <property type="gene ID" value="VR44_05110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1337"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="22988" checksum="2BE2BF437BA7BD8D" modified="2015-06-24" version="1">MGVVGKAFGWLADGANWSGESGVWHRLAEHLLVSGIALGVACVVALPVGLWLGHVGRGGALAVNLSNVGRAVPVFAVLALFMVSPLRSAGYLPTVVALVLFAVPPLLTNAYVGMREVDRSVVEAARGMGMSGGQLFWRVELPLARGLVMTGLRSGAVQVIATATIAAMVGQGGLGRIITAGFNTYNTPQVVAGALLVALLALLVEGLLVAADRLLPGRGRPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUG5</accession>
    <name>A0A0F4JUG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000106">
        <property type="protein sequence ID" value="KJY37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37408">
        <property type="protein sequence ID" value="KJY37408"/>
        <property type="gene ID" value="VR44_05740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1963"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="45" mass="4228" checksum="FF10376485557856" modified="2015-06-24" version="1" fragment="single">AAVVSAADAPADADRAAVRDLGGPQTPVLLAAPDGTLKSTTPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV74</accession>
    <name>A0A0F4JV74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000080">
        <property type="protein sequence ID" value="KJY38050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38050">
        <property type="protein sequence ID" value="KJY38050"/>
        <property type="gene ID" value="VR44_04400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.449"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_A_exoN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8665" checksum="90593C13A83D91FC" modified="2015-06-24" version="1" fragment="single">DKDPAAAARLSAARAAVSELAEGLNLPQENLITPDTVRRLCWEPPRNADTSAVAEALAGYGARPWQIEQVTPALVAALQASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWX6</accession>
    <name>A0A0F4JWX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000057">
        <property type="protein sequence ID" value="KJY38640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945792.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38640">
        <property type="protein sequence ID" value="KJY38640"/>
        <property type="gene ID" value="VR44_03095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7834"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="281" mass="28598" checksum="D002625669F31B36" modified="2015-06-24" version="1">MSHAGAPVGGLLVLVDPVARRLDGESVRIAKDVLSAGAAAKICLPDSQEEFARALARRGHRRPVVVGDDGALVRAVGLLHGEPGPGEVAVSLVPVGPAGSLALARSLGVPLSVVFAARAALDGVTRPRDLLVDDCGGVVLGGLRIAAPPAPAVRRAGGYRSLLRTLLPAPAAAPGAVQSLRVEVDGVVLVDADRPVEDVAVRTREDGGPARVVVRLPGGAPLTGYGEAVTVSVTGPAASFHYRADHAPAGLPTRRRTWTRLPSAWSLTLPRELGSSGPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYU3</accession>
    <name>A0A0F4JYU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_01795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945545.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39315">
        <property type="protein sequence ID" value="KJY39315"/>
        <property type="gene ID" value="VR44_01795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5763"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23634" checksum="E9100499BF7A567D" modified="2015-06-24" version="1">MERENSLRDRLIDVGVDLVMTEGTGSLGLREIARRAGVSHGAPRRYFPTHHSLLSAIAHRGLADLKDRFTAVTSGIPSARGQLEALGKAYIGYALEFRGMFELLLRHDLLDSRQNASDQPRLRELTLPLFGTIVELVARHREEDKVALRPGTTRDLPPPEISAGLLWSNLHGIAQLWAWGSLPLALGTAGTAGTGSGDDGVLDTLVATALDTHLGPVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZL8</accession>
    <name>A0A0F4JZL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4673"/>
    <dbReference type="EnsemblBacteria" id="KJY39560">
        <property type="protein sequence ID" value="KJY39560"/>
        <property type="gene ID" value="VR44_01370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2990"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="231"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="36940" checksum="486D7723126DFF38" modified="2015-06-24" version="1">MPAARTAPEDAASAAAAVPGARQAADAQTGGRPISVRALGTLGQGISVDPAEAGPGGSGSGRRRRLAEPAPQGRAFAIGAPEAGAAEGPEPLDGPGGAVEVVNRPVPPPVDDELPPEPLDNPRRLLVWPAPDPQTQQALSDRGYRPVIVHSREEVDAQIAAFPAALFVDPLTGPITRTALQSLRQAAMAAEVPVLVTAGLGHATREAAYGADPAVLLKALAPRDSEQHPSRVLLIEEHDEVATALTAALERRGLQVARAGADTDAVELATRMRPNLVVMDLMQVRRRRAGIVDWLRANGQLNRTPLVVYTATGIEPGDRPRLASGESVLFLAERSTTADVQGRIVDLLAKIGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0G3</accession>
    <name>A0A0F4K0G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945770.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38741">
        <property type="protein sequence ID" value="KJY38741"/>
        <property type="gene ID" value="VR44_03015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7335"/>
    <dbReference type="eggNOG" id="ENOG5031Y1M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="15237" checksum="6FEBF39DCEDAEB7D" modified="2015-06-24" version="1">MSATADHAENLAARLGFQSEQVVQEIGYDEDVDQDFRETVEALVSELADEDYDDVADAVLLWFRDEDGDLTDALVDATEMVEDGALILLLTPKTGRDGYVEASDISEAAETAGLSLAKGLPVGKEWTSTKLVTPKAAKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0L7</accession>
    <name>A0A0F4K0L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">VR44_00270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948644.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F4K0L7"/>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1022"/>
    <dbReference type="EnsemblBacteria" id="KJY39930">
        <property type="protein sequence ID" value="KJY39930"/>
        <property type="gene ID" value="VR44_00270"/>
    </dbReference>
    <dbReference type="GeneID" id="58435590"/>
    <dbReference type="GeneID" id="63982123"/>
    <dbReference type="GeneID" id="67399231"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.52"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="87AE8768EB157E09" modified="2015-06-24" version="1">MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGASVAGPVPLPTEKNVYCVIKSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1E0</accession>
    <name>A0A0F4K1E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39929">
        <property type="protein sequence ID" value="KJY39929"/>
        <property type="gene ID" value="VR44_00265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.51"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="42917" checksum="68B2B442D3052B1F" modified="2015-06-24" version="1">MDRQISDEEWARFSEEVARESADAPKEPSARARMVTERLRREEEERARAGRRRFGRAPKPGAGDPPGWRTGPAWQEMEGRGRVKRRLKAAAAIAVIVGLALVALRPELVIDKLTGKTDARQEARDAGPLPAESVRPTAAPEAGHPDRPTLKEPFRGSPAAQWADGAAAIEVPEATEVGGVPKERVGEALAQAKRFLVAANLDPAVLRGERPTAALDLLDPKDTKRREETARAYEHPSRENDPLELFTRYDPAELKLVGEVVKVRGRMWVEAGEKPGQADVKVDYTFVYPFVRTAGNPEDVARTIVRREATFQVFHGSAWGEPVNRLWLYRAAQDIANSTCGRFDGYVHPSFFSDPRDSGPAPSGSPVDPYDRSKSIGTDRAEECGTASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1Q4</accession>
    <name>A0A0F4K1Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000029">
        <property type="protein sequence ID" value="KJY39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945605.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39151">
        <property type="protein sequence ID" value="KJY39151"/>
        <property type="gene ID" value="VR44_02110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5686"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6527" checksum="43EA6C42C1AD42D3" modified="2015-06-24" version="1">MQSRPVITVALVVALTLAVVIAIGALPHDVQPMPRILALAAGISTVIYTLRRPRDGAPKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2A8</accession>
    <name>A0A0F4K2A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_01800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39316">
        <property type="protein sequence ID" value="KJY39316"/>
        <property type="gene ID" value="VR44_01800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5764"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="465" mass="47340" checksum="63409EF8F4B89B0C" modified="2015-06-24" version="1">MTETVRQRLALVVSVAGAMIVALDGTVLTVAQPELQRDFGASVEQIQWTSTGYMLAVAALLVIAGRLGDRYGHQRLLLLGVLGFGATSGGIMLAPDVRWVIGLRALQGVFGALLQPATLALLRLAYPADRLNTPVAIRTSSIGVAAAAGPVLGGFLVTHLGWRAVFMVNVPIAIAVLFVRVPAPSGGERQRLDLLGSALLAGTLTVMVHTLGAIPRDGWTSAPTLLGFLATAGLAAGLVVHERRTANPIVPPAVLRSVPVTASMVILLLTTSGMFGALFVGTFSLQDVLGLDPFAAGLRVLPMTVLMVFGAPAAAGALNRYGARRCAIAGTLLVAFGIVGLVRIEAPGPWWITGLAFAVLGAGFATVMVTATGTVVGDAPAGYAGVVGGLKQTAMNIGPTLGITVAATLMVVDPSYGGTPAAAAGTGDAVGVGHTLLVLAAIAALATLPGWLLPSRASREPEMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K388</accession>
    <name>A0A0F4K388_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat</name>
        <name evidence="5" type="ORF">VR44_01100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945415.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4724"/>
    <dbReference type="EnsemblBacteria" id="KJY39636">
        <property type="protein sequence ID" value="KJY39636"/>
        <property type="gene ID" value="VR44_01100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2933"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="32"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="38596" checksum="CD7DF4E02BB3FE18" modified="2015-06-24" version="1">MSEKSPKLRAELDGIPTYKPGKPAAEGGAVAFKLSSNENPYPPLPGVLETAVAAAGRFNRYPDMACTGLVNELAERFGVPAEHIATGTGSVGVAQSLIQSTAGPGDEVIYAWRSFEAYPIITQISGAKSVQVPLTDGDVHDLDAMAAAITDRTRLIFVCNPNNPTGTAVRRAELERFLDRVPSDVLVVLDEAYREFVRDTDVPDGIELYRNRPNVAVLRTFSKAYGLAGLRVGFAVAHEPVAAALRKTAVPFGVSQLAQDAAVASLRAEDELMGRVGALVCERNRVHETLLAQGWTVPDTQANFVWMRLGERTAEFAAACEKAGVVVRPFAGEGLRVTIGETEANDLFLHTAEAFFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K3Q9</accession>
    <name>A0A0F4K3Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000006">
        <property type="protein sequence ID" value="KJY39816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945310.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39816">
        <property type="protein sequence ID" value="KJY39816"/>
        <property type="gene ID" value="VR44_00495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.98"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="42470" checksum="79982C97E6540333" modified="2015-06-24" version="1">MRLSEDGDVVSENWRKAGWAGAAIGVIAAGAAAGVAVERITVGRGIRRKARLALDAAGDYGSLRGTEGTCRAEDGTELYYEVDEVEEAAAGGAKRRLRRKGAAPATVVFCHGYCLSQDSWHFQRAALRGVVRSVHWDQRSHGRSARGLAQADGEPVTIDQLGRDLKAVIDAAAPEGPLVLVGHSMGGMTVMALAEQFPELVRDRVLGVALVGTSSGRLDEVTYGLPSIGQGAVRRLLPGVLKALGSQVELVEKGRRATADLFAGMIKLYSFGSRDVDPGVARFAERLIEATPIDVVAEFYPAFQTHDKSAALQRFAGLPVTVVAGDRDMIIPPGHSVAIKEELPAAELVVLEETGHLMMLERPEIVTELLTGLLARAGAVPAPTNVGAHGRRTAGSAAQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I1K9</accession>
    <name>A0A0F4I1K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001820">
        <property type="protein sequence ID" value="KJY15910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15910">
        <property type="protein sequence ID" value="KJY15910"/>
        <property type="gene ID" value="VR44_40685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="10429" checksum="56283BD117FD6EEE" modified="2015-06-24" version="1" fragment="single">GKERKSDKETTPKQKEILTNQLHVWWAEQDKTFWDRVSRYCDANNPSVQQMVLEMNMVSDMSQTVSPQWVWARDTDKAGIALGLANQFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2E7</accession>
    <name>A0A0F4I2E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001831">
        <property type="protein sequence ID" value="KJY15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15864">
        <property type="protein sequence ID" value="KJY15864"/>
        <property type="gene ID" value="VR44_40730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6170" checksum="CA2CFABF583BB83A" modified="2015-06-24" version="1" fragment="single">MHSKTATTEEPAAARGAVAIITNRRGELLLHLRDDIPAIAWPGHWSLLGGGCDPGEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2R8</accession>
    <name>A0A0F4I2R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001868">
        <property type="protein sequence ID" value="KJY15773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene692"/>
    <dbReference type="EnsemblBacteria" id="KJY15773">
        <property type="protein sequence ID" value="KJY15773"/>
        <property type="gene ID" value="VR44_40850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7282"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY15773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7094" checksum="B4EDB185973AE0A7" modified="2015-06-24" version="1" fragment="single">SGRSFARVENGKVVFKAEIGAATAEACQIQGVWVAPEFRGRGHSETGMAAVVEFALRDVAPVVSLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3E0</accession>
    <name>A0A0F4I3E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001745">
        <property type="protein sequence ID" value="KJY16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16505">
        <property type="protein sequence ID" value="KJY16505"/>
        <property type="gene ID" value="VR44_40425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6740"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="10188" checksum="87C6A93AE764A5DD" modified="2015-06-24" version="1" fragment="single">FTVHVTYADGHEEKILAHAVIDASGTWAIPSPAGGDGLPALGERAAADRISYRVPDLNDPATRAWYAGKRTAVIGSGASAFTALASLADLAKSTDGAGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I728</accession>
    <name>A0A0F4I728_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001678">
        <property type="protein sequence ID" value="KJY17273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17273">
        <property type="protein sequence ID" value="KJY17273"/>
        <property type="gene ID" value="VR44_40035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35458" checksum="7043ABC452BA3A1A" modified="2015-06-24" version="1" fragment="single">DVLGVAAVVLDAEGRIRLWSPQAAALFGYPAEEALGRYAATLLVAEDNRDEVLGLFARVMAGQGAGAGSFPVRHRDGHTVLVEFRNMRLQADHGGMFALGLASEQATLRRVERDLALSLRLVDQSPIGLAVLDTDLRYVLVNPALERINGVPSERHLGQRIADILPFLDASAVEARMREVMETGVPVLDNFTTGRISEDAEERAWLVSIYRLEDQSSRVIGVAVSVVDVTEQHRVAVSAAHARRRLSLIADASVRIGTTLDLDITARELADVAVPEIADIAAVDVLDTVLPGGRPGEGPDERAVRFRALAVKAGYRTPAEEAADPVGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAX0</accession>
    <name>A0A0F4IAX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_39810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001643">
        <property type="protein sequence ID" value="KJY17811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17811">
        <property type="protein sequence ID" value="KJY17811"/>
        <property type="gene ID" value="VR44_39810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="117"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY17811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="43638" checksum="5F6583B212E45D47" modified="2015-06-24" version="1" fragment="single">EQAPADPHTAEADDTPDEAAPAPLPVPWLLSAKDENALRAQAERLLAHVRSAGRPDPADIALSLATTRAAFPHRAVITGHDRDGLLRGLAALAHGEAPGPETVTGTAPAGAGRSAFLFSGQGSQRLGMGRELHAVFPVFAEAFDAACAALDPHLELPLKGVVFGADTELLNETRFTQPALFAVEVALFRLLESWGVRPDLLAGHSVGEFAAAHAAGVFSLGDAAKLVAARGRLMQELPPGGVMVAVQASEEEVRSLLAGSEDRAGIAAVNGPVSVVLSGAEDVVTELAGKLAAEGRKTKALTVSHAFHSPLMEPMLDAFREAVASVSFETPGLPVVSTLTGGLVTAEEFASADYWVRHVREAVRFADAVTTLAAEGVGTFLEIGPGGVLTALAQESLDESAVTVPALRSDRPEDLAVTTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IK28</accession>
    <name>A0A0F4IK28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxylate carboligase</fullName>
            <ecNumber evidence="4">4.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001472">
        <property type="protein sequence ID" value="KJY20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20976">
        <property type="protein sequence ID" value="KJY20976"/>
        <property type="gene ID" value="VR44_38430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5336"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_M" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="181"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="41773" checksum="9AAFE98B8D4F3720" modified="2015-06-24" version="1" fragment="single">IINADASDLLVEFAELTGIPVISTLMGWGTIPDDHELAAGMVGVQTAHRYGNATFLESDTVIGIGNRWANRHTGYNLEAYTKGRKFVHVDIEPTQLGKIFAPDFGIASDAKAALELFIEVAKEWKAEGKLPDFSAWAASAQERKATLQRRTHFENIPMKPQRVYEEMNKAFGPETRYVTTIGLSQIAAAQFLHVYKPRHWVNCGQAGPLGWTIPAAIGAATAQPDVPVVALSGDYDFQFMIEELAVAAQHKVPYVHVLVNNAYLGLIRQAQGGLGINFEVNLEFENINTPEIGVYGVDHVKVAEGLGVKAIRVTDPDKLGEAFEEAKKLAQEFQVPVVVEAILERVTNIAMSKTVDMSDVTEFEELATEPGHAPTAIKPLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILK9</accession>
    <name>A0A0F4ILK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001418">
        <property type="protein sequence ID" value="KJY22554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952221.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001418.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22554">
        <property type="protein sequence ID" value="KJY22554"/>
        <property type="gene ID" value="VR44_37900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5140"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="41721" checksum="597C2A17298FD6A5" modified="2015-06-24" version="1" fragment="single">MWRLAPEGRGPVRYGPPAPEPGLPVLPELKVVLAGAADRAAPEPPGGGEPVREAACRHWARRGLATEPEYVAAGPGAPALLLALLGAYGGDVMLPRPCPAWWTPQVRLLGRRAYHVPTPAECGGVPDPYALLETVRRVRAEGGDPRVLLLSVADDPTGTVPPPEMLREACEAADAAGLFVVSDESWRDTVHRPHDTLVLSPAEMLPDTAAVLVDLSGSLLPGGWPAAVARFPATPRGTWLRARTLDILTATGALPAGPVAVAAAHALEEPDAVAGRAYAAAALHGAVAAAAHRELLAAGAFARPPQAGRHLYADLAPLRAGLARHGVGDAMELEDWLGARLGSPTPGGQRFADELGALRVRLSTGPLLGSTPQERLAALGSREPLELPHVRGALDLLGSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP39</accession>
    <name>A0A0F4IP39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001358">
        <property type="protein sequence ID" value="KJY23800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23800">
        <property type="protein sequence ID" value="KJY23800"/>
        <property type="gene ID" value="VR44_37220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="11969" checksum="52348ADBC71556C0" modified="2015-06-24" version="1" fragment="single">MGPADCPGAAGGAASVSGSPPPVPGTCGTCGDTCAEGLDDTEGTWGSCCPSEASARPMTVPSARAGAGAGGGKALPNSAARFFGVSGGGSWARRITGLTWVTASDPGAGAPACPARAAAAAAGLASFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP88</accession>
    <name>A0A0F4IP88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allergen V5/Tpx-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001348">
        <property type="protein sequence ID" value="KJY23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23847">
        <property type="protein sequence ID" value="KJY23847"/>
        <property type="gene ID" value="VR44_37085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4805"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470137" evidence="1">
        <location>
            <begin position="26"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="19469" checksum="6A532ACCE1C053F4" modified="2015-06-24" version="1">MALSLATAGCLALTLLPVTAAPASAAYCDPAASGSPPAAGGDAARLAVACLINAERTQRGLQPLTSNPSLTAAAQQHTAAAVQLKWWGPGKDSHTNPQTGSTPQSRIKAAGYCQNPRSWAVSEITYTGWGGSGTPKAAVTWWMNSPTHRSIILDGSLREYGSWAQAGAADRAGAGASGAGTYVVTFGRCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ77</accession>
    <name>A0A0F4IQ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001281">
        <property type="protein sequence ID" value="KJY24152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24152">
        <property type="protein sequence ID" value="KJY24152"/>
        <property type="gene ID" value="VR44_36200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4483"/>
    <dbReference type="eggNOG" id="ENOG502ZR7F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="36140" checksum="44491471787FF4F2" modified="2015-06-24" version="1">MLARGKREGEKAAADDSWERSEERRRRKEAVYGTASYVLLFCCAAVAAALSFHGLVGFGRQNLNLSGGWEYLVPFGLDGAAMFCSVLAVREASHGDAALGSRMLVWLFAGAAAWFNWVHAPRGSGHDGAPQFFAGMSLSAAVLFDRALKQTRRAALREQGLIPRPLPQIRMVRWLRAPRETFGAWSLMLLEGVRTLDEAVDEVREDKKEREQDRHRRREQHRLDRARIKALGRQNRAFGRARARQVDLPGLNPGTGSAPVGAEPAISEPGQLPLRRRPSLQAVNTAESADPAGPRTVDLTAEDDTQTIPRLDSLERKLKDLEQQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQY0</accession>
    <name>A0A0F4IQY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_36910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001335">
        <property type="protein sequence ID" value="KJY23903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952039.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001335.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23903">
        <property type="protein sequence ID" value="KJY23903"/>
        <property type="gene ID" value="VR44_36910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4698"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="27070" checksum="6B03C7EC91EBE8F8" modified="2015-06-24" version="1">MKIALMDSGIGLLAAAAATRRLRPDADLLLSSDPDGMPWGPRTPADLTERARLVARAAAALRPDALIVACNTASVHSLATLRAELEPGIPVIGTVPAIKPAAAAGGRVAIWATPATTGSPYQRGLIRDFAAGVRVTEVPCPGLADAVEYGDEEAIARTVAAAAELTPADVTDVVLGCTHYELVEEAIRAALAARTGGADLRYHGSAEAVAVQALRRIGAGPAPELPRTGGLTVLHTGRPSTLPAAALGYAEGRLLAGQDHGAAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR84</accession>
    <name>A0A0F4IR84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001273">
        <property type="protein sequence ID" value="KJY24184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951888.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001273.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene554"/>
    <dbReference type="EnsemblBacteria" id="KJY24184">
        <property type="protein sequence ID" value="KJY24184"/>
        <property type="gene ID" value="VR44_36110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4462"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="291"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="599" mass="66391" checksum="B8EA901F35B4F792" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRY2</accession>
    <name>A0A0F4IRY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001263">
        <property type="protein sequence ID" value="KJY24243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951852.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001263.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24243">
        <property type="protein sequence ID" value="KJY24243"/>
        <property type="gene ID" value="VR44_35930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="306" mass="32005" checksum="9A699D81E3C2FC76" modified="2015-06-24" version="1">MDVVSDAISAVRLGRASSDRVRTAGTWCVRLDPYEGAGFHVVLAGDCWLLADGGEPVPLATGDAVLLPHGAGHVLADSPVDAAVAARARPLEHYLDGRAAAPAPQPGRPAVEMLCGKYRLDRSRVHPLLAELPGVVRLQGGSHGELQSAIALLGGELDARRPGSSIALPSLLDLLLVYMVRASVAGAAPGSWSAALGDPVTAAALQAMHADPAAPWSADRLAAEAGVSRPTLVRRFTPLVGRPPMAYLTWWRLTLAATRLRDTQDSLAAIAAGVGYGSPYALSHAFVREFGTTPGRYRTEITRTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT13</accession>
    <name>A0A0F4IT13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_37080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001348">
        <property type="protein sequence ID" value="KJY23846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952070.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23846">
        <property type="protein sequence ID" value="KJY23846"/>
        <property type="gene ID" value="VR44_37080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="455" mass="48645" checksum="49F05D965EC65208" modified="2015-06-24" version="1">MSSSAVTLGPPPGDERRRRRLALVGGSLGNLVEWYDWFVYASFAIYFADSFFPNDNPTTQLMNTAGIFAVGFLMRPVGGWVLGRAADRHGRKSALTLTVTMMSVAALLIAVAPTYGQAGYFGAVVLLLARLLQGMSIGGEYAASATYLTEASARNRRGLGSSFQYVSMTCGQLLGLGILITMQHTLTKQQLGSWGWRVPFVLGAVFAVVVFWLRRRLQETDAFKEGGAHDDSARGSLRALWEHRRQAGLVMALTLGGTVAYYTYTTYLTKYLVGSAGMAKNTATLVSFTALAVFAVLQPFAGMLSDRIGRRPLLITFAVGCTVGTYPIMTALGSASSYWSALGLSLLALVIVTGYTSINAAVKAELFPTRVRALGVALPYAVANALFGGTAEYVALWFKNGGHEKAFFWYVSGCALVSLVTYVLMPDTRDAALSRAEEEAGARSEAAPAGAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITW8</accession>
    <name>A0A0F4ITW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001148">
        <property type="protein sequence ID" value="KJY24918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951489.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001148.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24918">
        <property type="protein sequence ID" value="KJY24918"/>
        <property type="gene ID" value="VR44_33960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3718"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="33621" checksum="FEC6B70698B6F138" modified="2015-06-24" version="1">MSNTPLAPAPVTSEHIDLQARNVSFSWEDTPLHWLPGEPFAGHTINVLHLLLPAGERWFVHVYKQVLPYITDERLRADVVGFIGQEAMHAAAHDDVLPHLKRLGLDPTPYTAQVDWFFEKLLGDRTLPPGRARKWWLMERVALIAAIEHYTAFLGDWVLNAEELDRRGADPMMLDLLRWHGAEEVEHRSVAFDLFMHVDGNYRRRARTWASAFAALVFLWQRGVRFFVENDPQRPGAKASFGQFHRAGRKGLLPSTGSMVRSIPTYLSRTYHPSQEGSTAQAVAYLASSPGANGGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUD2</accession>
    <name>A0A0F4IUD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_32995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001101">
        <property type="protein sequence ID" value="KJY25254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25254">
        <property type="protein sequence ID" value="KJY25254"/>
        <property type="gene ID" value="VR44_32995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3420"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20903" checksum="59690C5C03E5F00F" modified="2015-06-24" version="1" fragment="single">RADALREALATRVVVADGAMGTMLQAQDPTLEDFQQLEGCNEVLNITRPDIVRSVHEAYFSVGVDCVETNTFGANYAALAEYDIPERNFELSEAGARIARQVADEFTASTGQQRWVLGSIGPGTKLPTLGHITYAQIRDAYQVNAEGLISGGADALLVETTQDLLQTKSSIIGARRAMEALGVTVPLICSVTVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV00</accession>
    <name>A0A0F4IV00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001018">
        <property type="protein sequence ID" value="KJY25847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25847">
        <property type="protein sequence ID" value="KJY25847"/>
        <property type="gene ID" value="VR44_31425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25547" checksum="7179C2DD2BE78216" modified="2015-06-24" version="1" fragment="single">MTTSQKTALITGANKGIGKETARRLAALGITVLIGARNAERGEAAAEELRADGADVRFVPLDVTDENSVRAAARHIDDTFGRLDILVNNAAIATGQQKPSETPAATVREVYETNVFGAIAVTHAMLPLLRRSAAARIVNMSSELGSLTHLADPDSPWSAYTSTLLPYSTSKSALNAVTVLYANELRAEGILVNAVSPGYCATDLNRHSGPRTAQEGAAVAVALATAGEDGPTGTLRSEDGPIPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV99</accession>
    <name>A0A0F4IV99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001056">
        <property type="protein sequence ID" value="KJY25564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951151.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25564">
        <property type="protein sequence ID" value="KJY25564"/>
        <property type="gene ID" value="VR44_32120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3143"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="39826" checksum="FFC5CE905FF7B172" modified="2015-06-24" version="1">MTPNGRQRSTTDDRELRLWRVGWALTVAFIAAVLVAGGIFYGLVDVLGFKKIDTTTKLDANTLFDLVKLSFGVVAGAGALVALVVAYRRQRVDEAGAHREATRLHTERFSQAVDKLGSGSPAVRLGGVHALAGLADDAPDDSLRQTCIDVLCAYLQLPFTPDPGTDPAHQDEHHQYLALRKVRHTILRLISDHYRRPRGTHRSWQGCDLDLTGVTIDGNMNFDGATLSGGRVIFEGATFSGGTVSFRGATFSGGTVPFEGATFSAGTLSFDGATFSGGTVSFRGATFSGGTVSFHGATFLAGTVSFNGTRFTRGGVSFSGMRFPRGVVSFYSAAFSGGWVRFDRVAGEAPAGLHNAIDAAVPPVPLPLAWQPINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVD4</accession>
    <name>A0A0F4IVD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">hisE</name>
        <name evidence="11" type="ORF">VR44_32540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="JZWV01001075">
        <property type="protein sequence ID" value="KJY25423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951232.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001075.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7171"/>
    <dbReference type="EnsemblBacteria" id="KJY25423">
        <property type="protein sequence ID" value="KJY25423"/>
        <property type="gene ID" value="VR44_32540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3320"/>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY25423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9868" checksum="778E414384E85335" modified="2015-06-24" version="1">MANKTFEELFTELQLKAADGDPSTSRTAELVGKGVHAIGKKIVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVMMVARGISLDDVYSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW96</accession>
    <name>A0A0F4IW96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001011">
        <property type="protein sequence ID" value="KJY25914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950992.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25914">
        <property type="protein sequence ID" value="KJY25914"/>
        <property type="gene ID" value="VR44_31275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2742"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="12285" checksum="7CEB1853575ED01F" modified="2015-06-24" version="1">MPERGPKAARWDDLVEEFGFSAEERAEVDRGAAEMIAVVRAHRLAEVRKRQRTTQVQVAEAMGVTQARVSRIENGQLERSEVETLAAYVRALGGRLKIVAEFGDEQYVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWK9</accession>
    <name>A0A0F4IWK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001017">
        <property type="protein sequence ID" value="KJY25858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25858">
        <property type="protein sequence ID" value="KJY25858"/>
        <property type="gene ID" value="VR44_31395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2769"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469900" evidence="2">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7751" checksum="67D018B686CBF0B4" modified="2015-06-24" version="1">MQALRVKRLFAASAIGVLLAGGAAMGAAGTASAAVPTHAVAYSHGGGGWDDDDDWGGHGHGWYDDDDDWGGGYDDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX97</accession>
    <name>A0A0F4IX97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000915">
        <property type="protein sequence ID" value="KJY26632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950688.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000915.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26632">
        <property type="protein sequence ID" value="KJY26632"/>
        <property type="gene ID" value="VR44_29590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2297"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="18797" checksum="6C84E00D6CFDD13C" modified="2015-06-24" version="1">MSDTALLIIDMQGALLGDAHEAEACLREIADLAGRARSAGVPVFYLRQRLPDVPADLADVHPAVAPLPGDVVLDKDSADSFLQTGLGDSLDRRAVRRVVVTGFASEYCVDSTCRSALSRGYDLVLVSDGHTTPERPPGSAPTAAQVIAHHNATLSAIQYAGRSIAVVPTAQVRFGGAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXM1</accession>
    <name>A0A0F4IXM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950619.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000904.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26785">
        <property type="protein sequence ID" value="KJY26785"/>
        <property type="gene ID" value="VR44_29230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2191"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="21441" checksum="1B0420D6818F511D" modified="2015-06-24" version="1">MAAEGPGGDSPPRSKRADAQRNRETVLTAAAEVFATSGVDAPIRQIAARAGVGMATIYRHFPTRADLVTAVYQHQIEACAEAGPNLLARADSPLDALHQWTDLFVDFLVTKHGLADALQSDSDRFAALHAYFLDRLLPVCAQLLDAAVEAGDIRPGTQPYELMRGIGNLCIGRDDDPRYDPRRLIALLLQGLQRPQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXU1</accession>
    <name>A0A0F4IXU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951209.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25476">
        <property type="protein sequence ID" value="KJY25476"/>
        <property type="gene ID" value="VR44_32390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045772">
        <property type="entry name" value="DUF6225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19735">
        <property type="entry name" value="DUF6225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6618" checksum="62A13D58B64557B0" modified="2015-06-24" version="1" fragment="single">MADMFEHAPQVWTAARLREALTDLPDETPIHIGVADGPGDFDGYGEYVLVDAEPVEMDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY58</accession>
    <name>A0A0F4IY58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate carboxyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000885">
        <property type="protein sequence ID" value="KJY26927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950551.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000885.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26927">
        <property type="protein sequence ID" value="KJY26927"/>
        <property type="gene ID" value="VR44_28850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2110"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="40837" checksum="3E10E1A72C345B21" modified="2015-06-24" version="1">MTGTASAARKILVCDTTLRDGEQTCGVAFQVEEKVKIAQLLDEMGVDVIDAGFPASSQADQDAVRGIAALGLNARVVAFCRPNRTEIDLARACGANAIYTFVPTSDVHMRVKFGGTDSAVRERLKAEMADGIKYAKGLGMYVGCGSEDATRTPYDYLEEVLVLAQESGADLVGVADTVGSTTPDAFRTLISRLRSQIGVTLSLHCHNDFGLATANTVAGILGGADEVQCTINGIGERAGNASLEEVTVALTQLYGFETNVDLSRLKPMSDLIAGLSGIEVSPMKPIVGGNAFSHESGLHVSSVMKDSTAYEPLRPELVGHTRRIVMGKHSGKGIIAHVLDAHGLPYDDEVLAAVLLDVKAASVLTKSSVTEAQVIEIHRERTAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYG4</accession>
    <name>A0A0F4IYG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000876">
        <property type="protein sequence ID" value="KJY27042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950490.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000876.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27042">
        <property type="protein sequence ID" value="KJY27042"/>
        <property type="gene ID" value="VR44_28515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2031"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="40569" checksum="48DFF63DDBE39E29" modified="2015-06-24" version="1">MSPVVTPAACADIAELRQLYYAVYGPHYPVALGTDPAEMARLIEDPHSLWLVARCADTGALTGSAAIHGEAGSRIGRLEGIAVHPGHRSAGLAATLTGALCAGMLDTGRLDSVYATVRTVSAGPQRVVARNGFRPLGILPNAVDLRSRESLALYARHSAGVLDRRIPVTEVPAPLLPLLHTAEAALGIRYPGVRAAAAAPRPAPSAPQGADDRLEMIEAPAFVRRRFRERFPGADGWFYPLHTPNVLLTPEDGRFEVYAYLNRAGGYCSLLTAHPDPAAAAACLEPVTRALARAGAGYVEALVPLAHHEVLSAFLAEGFVAGAVYPAMRADGDGFHDYAVLSRSGERIDFRGVAVEPPLQPYLDCYVSAWASTHLPTPSEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYS1</accession>
    <name>A0A0F4IYS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000901">
        <property type="protein sequence ID" value="KJY26809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26809">
        <property type="protein sequence ID" value="KJY26809"/>
        <property type="gene ID" value="VR44_29145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7419" checksum="F42EA6CF3CCCC8DE" modified="2015-06-24" version="1" fragment="single">MSHGLSDQAAAVLGVMADKAPEVFAATVRFLPAITAAHEAGTVPPGATPTDQWGDVFDTAVPGAPVIVEWFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ02</accession>
    <name>A0A0F4IZ02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950412.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27232">
        <property type="protein sequence ID" value="KJY27232"/>
        <property type="gene ID" value="VR44_28080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1859"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10388" checksum="2AF9A1E19094196E" modified="2015-06-24" version="1">MIVAFSVTPLGVGEEVGEYVADAVRVVRESGLPNRTDAMFTTVEGEWDEVMDVGAVAAVEERAPRVSFILKADIRPGVTDGITSKVETVERHLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ72</accession>
    <name>A0A0F4IZ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000849">
        <property type="protein sequence ID" value="KJY27312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950379.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000849.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27312">
        <property type="protein sequence ID" value="KJY27312"/>
        <property type="gene ID" value="VR44_27895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1828"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="39232" checksum="A714414466AF74FF" modified="2015-06-24" version="1" fragment="single">GQRIRLRTARNLTEATRLLTPDVHCVLLDLALPGPGEDGFGALREVLRIAPRHAVLVLTAEADADRAAEAVRVGAQDFLFRDELDGRLLSRAIRYAVERKRADIAQYKLAESKLRAQENARLERGLLPTPLLEGSGLRFAARYRPGRSRALLGGDFYDAVRTPDGTVHAMIGDVCGHGPDEAALGVELRIAWRALTLAGLCGDDLLATLQEVLEVERPCEEIFATLCTVDISPDGRSAGLCLAGHPAPLVSRPGRAARLLPYENSGPALGLLPRARWPRRQVDLGGTWSLMLYTDGLIEGRIGEGRERLGQDGMVDMINRHLQDGLSGEGLLEASVTEARRLNGGELTDDVALVLLSRSQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZK6</accession>
    <name>A0A0F4IZK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_27560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000833">
        <property type="protein sequence ID" value="KJY27445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27445">
        <property type="protein sequence ID" value="KJY27445"/>
        <property type="gene ID" value="VR44_27560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="28046" checksum="1F19A28559AA5991" modified="2015-06-24" version="1" fragment="single">MQPLTATDPRRVGAYRLLYRLGEGGMGRVYLGRSPGGRTVALKVVHGTIAGDPGFRRRFAREVRAARSLRGAGTVPVLDADPEAEVPWLATAYVPGPALSDAVIGHGPLPQEALWRLLSGLAQALAGVHGAGLVHRDVKPSNVLLSPSGPLLIDFGIARSADETVLTGTGLVVGSPGYMSPEQAEGRTVGPAADVFSLGAVLAFAATGRGPFGGGSVAELLYRLVHHEPDLDGVGGPFGDLTRHCLAKRPADRPAVAELAAAAAQRAGTGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J195</accession>
    <name>A0A0F4J195_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000767">
        <property type="protein sequence ID" value="KJY28055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950062.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000767.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28055">
        <property type="protein sequence ID" value="KJY28055"/>
        <property type="gene ID" value="VR44_26180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1393"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22925" checksum="1574736E63754139" modified="2015-06-24" version="1">MAFAVSEAGPDTALLLDDEPVQPWQYDRSRAPVAVKVLVAGGFGVGKTTFVSSVSEITPLRTEAVMTQASVPTDDLTGTPDKNTTTVAMDFGRITLADDLVLYVYGTPGQERFWFMWDDLVRGAIGGLVLADTRRLRDCFPALDYFESCGLPYAVAVNHFEGSKEYEPEDVREALTIPPDVPVVIMDARRRATVVESLLTLVGHALDATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1B7</accession>
    <name>A0A0F4J1B7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="4" type="ORF">VR44_27120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000809">
        <property type="protein sequence ID" value="KJY27664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950240.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000809.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6914"/>
    <dbReference type="EnsemblBacteria" id="KJY27664">
        <property type="protein sequence ID" value="KJY27664"/>
        <property type="gene ID" value="VR44_27120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1609"/>
    <dbReference type="eggNOG" id="COG3442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="3">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26248" checksum="4F3DFFE8AB044D75" modified="2015-06-24" version="1">MSDNSLRLVWVYPDLLSTYGDQGNVLVVERRARQRGLDVQRVDVRSDQPIPTSGDIYLIGGGEDRPQRLAAERLLRDGGLERAVSNGAIVFSVCAGYQILGNEFVNDMGERQQGLGLLDVVTVRGEGERCVGDVLADIDPRLNLPPLTGFENHQGVTHLGPTAKPFARTRLGRGNGTGDGTEGAYNDTVFGTYMHGPVMARNPLIADLLLKLALDVNALPAIDDRWYDALRAERIAAATQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1G4</accession>
    <name>A0A0F4J1G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000818">
        <property type="protein sequence ID" value="KJY27573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27573">
        <property type="protein sequence ID" value="KJY27573"/>
        <property type="gene ID" value="VR44_27235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1583"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="10960" checksum="F3DF75D8DFBDCAE0" modified="2015-06-24" version="1" fragment="single">TALAAAHRGPARGRISGLGLRLFLQAVARGAHVGTAASIVGLRSDQLLRLRRANPLVAALVDAAVQQARGLRGSDRRPKRAPAYRLVTLRAPAPGHEAPDPPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1J6</accession>
    <name>A0A0F4J1J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000801">
        <property type="protein sequence ID" value="KJY27744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950195.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000801.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27744">
        <property type="protein sequence ID" value="KJY27744"/>
        <property type="gene ID" value="VR44_26880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1535"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="48281" checksum="FC648ED5DD3D2F24" modified="2015-06-24" version="1">MKAHDGMYIGGEWRPAAGSGRIEVINPADEQVIGGVPAGTAEDVDAAVRAARAAFPGWAATPAAERAALIGALRDVLVARRTEIAETVTAELGSPLGFAEAVHVGAPIAVAASYAKLAASYAFEERLGNSTVFLEPVGVVGAITPWNYPLHQVVAKVAPALAAGCTIVLKPAEDTPLTAQLFAEAVHEAGIPAGVFNLVTGTGPVAGQALAEHEGVDLVSFTGSTAVGKKIGAIAGAAVKRVALELGGKSANVILPGADLAKAVAAGVGHVMNNTGQSCNALTRMLVHRDQYEEAVALAAAAVANYPSGDPRDPGTRLGPVVNAKQRDRVRGYIATGVEEGARLVAGGLDAPHERGYFIAPTVFADVTPEMTIAQEEIFGPVLSILSYQDEEDALRIANGTVYGLGGAVWAADAETAVAFARRMDTGQVDINGGRFNVLAPFGGYKQSGVGRELGPHGLGEYLQTKSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1U8</accession>
    <name>A0A0F4J1U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ORF">VR44_27000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="JZWV01000806">
        <property type="protein sequence ID" value="KJY27703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950216.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000806.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5229"/>
    <dbReference type="EnsemblBacteria" id="KJY27703">
        <property type="protein sequence ID" value="KJY27703"/>
        <property type="gene ID" value="VR44_27000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1562"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="226"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY27703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="496" mass="53787" checksum="AB59758908BF527A" modified="2015-06-24" version="1">MDLETFRKLAADRRVIPVSRRLLADGDTPVGLYRKLAAERPGTFLLESAENGRSWSRYSFVGVRSDSTLTVKDGEAHWIGTPPVGVPTDGDPLEALRATVQALHTPRDLAGGMPPFTGGMVGYLGYDIVRRLERIGDHTEDDLKLPELTMLLTSDLAVLDHWDGTVQLIANAINHNDLDTGVDEAYADAVARLDAMEADLARPAPYAPAALPESELPPFDALWGGEKYQAAVEDVKERIRAGEAFQVVPSQRFETPCEASALDVYRVLRATNPSPYMYLFRFENGFDVVGSSPEALVKVEDGRAMVHPIAGTRHRGATPQEDNDLAEELLADPKERAEHLMLVDLGRNDLGRVCEPGSVEVVDFMSIERYSHVMHIVSTVTGRVAEGKTAFDVLTACFPAGTLSGAPKPRAMQIIEELEPSRRGLYGGCVGYLDFAGDSDTAIAIRTALLRDGTAYVQAGAGVVADSVPELEDQECRNKAAAVLRAVGAANRLHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1X0</accession>
    <name>A0A0F4J1X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949969.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1580"/>
    <dbReference type="EnsemblBacteria" id="KJY28292">
        <property type="protein sequence ID" value="KJY28292"/>
        <property type="gene ID" value="VR44_25690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1237"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="28221" checksum="1EE3AB9168BD4E34" modified="2015-06-24" version="1">MSLAPAGVLVAEAAAAGRAVAAFNVITLEHAEAVVEGAERAGTPVILQLSENAVKFRGGALLPISRAAAACAEAARVPVGLHLDHVKSPDLLRQAADAGFGSVMYDAAHLPYAENLEATRSAADWAHANGLWIEAELGEVGGKNGAAPLDPHAPGARTDPDEARRFVADSGVDALAVAIGSTHAMTSRTASLDHALLARLAKTVDVPLVLHGSSGLPDAELAAAVAGGIRKVNIGTALNVAMTEAIRTHLTGADPRPYLTAARTAMAATAEAMIAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J269</accession>
    <name>A0A0F4J269_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000739">
        <property type="protein sequence ID" value="KJY28355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949942.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000739.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28355">
        <property type="protein sequence ID" value="KJY28355"/>
        <property type="gene ID" value="VR44_25545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14727" checksum="11488613EEAED333" modified="2015-06-24" version="1" fragment="single">MNEVLERLRAEADGSPGYAELLAAGPDALTSAGQPLWARELAAYRLGMARDRRAFEPLVLLLNHRDPARCEAAAQALGVLGDPRTARAAAALATNTLRTAYALHPVRLLAALRAPESAPALISTLSRLLAPHDPYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2V7</accession>
    <name>A0A0F4J2V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000768">
        <property type="protein sequence ID" value="KJY28048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950068.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000768.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000047_gene2135"/>
    <dbReference type="EnsemblBacteria" id="KJY28048">
        <property type="protein sequence ID" value="KJY28048"/>
        <property type="gene ID" value="VR44_26215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1399"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="104"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="363"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="454" mass="46691" checksum="9C2FE8F7DEEA1883" modified="2015-06-24" version="1">MLTALDGTYGDRPDAVAVAGRTASYEELLGAARAVAADIAGAPAFAVTATASLETVAAAVGGLLAGVPFVPLPPDAGPAEREHILRDSGAALTTVDFARRSDATPPGPADPQDPALILYTSGTTGPPKGVVLTADALAADLDALATAWQWTAEDTLVHGLPLFHVHGLVLGVLGALRTGSRLVHTGRPTPQAYAAAGGSLYFGVPTVWSRIAADPTAAAALSGARLLVSGSAALPAPVFRDLERLTGHRPVERYGMTETLITVSGRAGGEVRPGTVGTPLPGIRTRIAAEPGADIGELQLTGPTLFAGYLGRPEATAAAYTEDGWFRTGDIAAVDPEDGVHRIVGRASIDMIKSGGYRIGAGEIENALLDHPKVSEAAVVGVPDTDLGQRIVAFVVAEGVTGAELTDFVATHLSVHKRPREVRFVAAIPRNAMGKPQKKLLLTDAPDTPHGTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J333</accession>
    <name>A0A0F4J333_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000704">
        <property type="protein sequence ID" value="KJY28757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28757">
        <property type="protein sequence ID" value="KJY28757"/>
        <property type="gene ID" value="VR44_24645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.924"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="8330" checksum="758B75DEA47C1D2F" modified="2015-06-24" version="1">MANGRYSAGRGPVSCRIIGGVTGGSWSKLTRSADTVLMRMAGSHSGNHRRLLPLGASPVLLLWGAPVVRGCLRCLPAVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J428</accession>
    <name>A0A0F4J428_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949898.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000730.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1632"/>
    <dbReference type="EnsemblBacteria" id="KJY28453">
        <property type="protein sequence ID" value="KJY28453"/>
        <property type="gene ID" value="VR44_25310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1159"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="25310" checksum="F07DFF0FA561A25D" modified="2015-06-24" version="1">MGKQLVAVFSGAGMSTDSGIPDYRGPQGLWRRDPEAEKLVTYEYYMADPEVRRRSWLMRAEIGALGARPNAAHTAVAELERAGTPVRVITQNVDGLHQLAGMPERKVFELHGTARSVVCTGCRARSGMDEALARVAAGEPDPACPACGGILKAATVMFGERLDPEVLARAVAVAKGCQVFIAVGTTLQVQPAASLAGMAAEAGARLIIVNAEETPYDSLAAEVIREPIGTALPALLARFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J466</accession>
    <name>A0A0F4J466_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000803">
        <property type="protein sequence ID" value="KJY27731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27731">
        <property type="protein sequence ID" value="KJY27731"/>
        <property type="gene ID" value="VR44_26915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1544"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20204" checksum="B52377C06311B73C" modified="2015-06-24" version="1" fragment="single">MQQRAGSRPTELDPFDRTLAHALSIDGRAPFSRLAEVLEVSDQTVVRRYHRLRGNGLLRVVGLPVGSRVGLFESWLRVQCAPDAAVAVAEALARRPDIAWVSLNSGGTEIHCMTRARTREDRDALLLEKLPRTRRVTAISAHTVLRKYIGGPGVWAGLQGLRPDQVAALRPPGPAPEYQGARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J490</accession>
    <name>A0A0F4J490_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000723">
        <property type="protein sequence ID" value="KJY28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949872.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000723.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28518">
        <property type="protein sequence ID" value="KJY28518"/>
        <property type="gene ID" value="VR44_25160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1124"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="21333" checksum="BBAB703BD9297AB7" modified="2015-06-24" version="1">MSAAESWSRVMGLLREHAPSDHADLPGPATEQMLAAAEGRMGIRLHGDLRTWLLQNNLDLPEEEFDDDVMCCGFDGFPDEGSFLLGVRAMERLYANRSTSCGFDPPDQPDHPFWRNEWIPFLSDQDGWRGKFIDVRDGRVGSWFVGEMTVTGEYESMAQYFDSVAETLTRIADGSSPVCRFTEGRLLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J508</accession>
    <name>A0A0F4J508_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29345">
        <property type="protein sequence ID" value="KJY29345"/>
        <property type="gene ID" value="VR44_23210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.582"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="7173" checksum="9C85AC650AA5836B" modified="2015-06-24" version="1" fragment="single">DANAKKALELTFREALRLGHGYVGTEHILLALLELENGEGTLSGLGLDKAAAESAVTEALAAVLGADGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5N6</accession>
    <name>A0A0F4J5N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000750">
        <property type="protein sequence ID" value="KJY28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28236">
        <property type="protein sequence ID" value="KJY28236"/>
        <property type="gene ID" value="VR44_25830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1270"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8526" checksum="4DE71DD448ECFBD5" modified="2015-06-24" version="1" fragment="single">LLTDTGRLAAATARVLRGRRVTGRFHAVRLRPGSGAAWACGLLSATPGLYVVDLRPPGATALAHTLPGRPTALERALTSGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J683</accession>
    <name>A0A0F4J683_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_23115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000651">
        <property type="protein sequence ID" value="KJY29349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29349">
        <property type="protein sequence ID" value="KJY29349"/>
        <property type="gene ID" value="VR44_23115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.562"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="345"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="693"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="266"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY29349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="813" mass="88068" checksum="3559B38D6B2131C7" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6E0</accession>
    <name>A0A0F4J6E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949481.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29409">
        <property type="protein sequence ID" value="KJY29409"/>
        <property type="gene ID" value="VR44_23035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.544"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="30219" checksum="F925809E9EA1D196" modified="2015-06-24" version="1">MTTTSHRTQAAERYALAVAGCVIIALTAAGFWLSYAHLAEVAGLHGLGTSPARQWAWPATLDAFIVAGEVLMLRASLRRESDGWAIALTAAGSLGSIALNVAGVSRSDGVPASALDYVVAAVPPAAALFAFGVLMRQIHRHVAAEESRHSRRPVGEPSAHPANLDRPRGHSATPQLPDPEWHSGHEGDRPTPAGAIRGASVNVAEETDQVAEACVPPKKRTGRKPAATDDELLDIARTAPLGLKGRASSRHIETAVRARGLPIGRDRRNKITRQVQAELDSGQANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J719</accession>
    <name>A0A0F4J719_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949400.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29568">
        <property type="protein sequence ID" value="KJY29568"/>
        <property type="gene ID" value="VR44_22600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.412"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="35017" checksum="F51F444C751A228E" modified="2015-06-24" version="1">MRAVDDACREAPALSVAVPVFNEEEVLPVLAARLRPVLDGCGEPYEVLAVDDGSNDRTPLLLEELRAAWPQLRVVTLRRNSGHQAALTAGLRRARGAYVVSIDADLQDPPEVIPEMLALARTQGLDIVYGVRGDRSTDSGFKRRTAGAYYRLMRRLAGAHVPAQAGDFRLLSRAVVDTLKTLPDQQQIYRLLIPWLGFPSGQVAYRRAERAAGTSKYPLHKMVLLAFDSITGFSAVPLRLATAIGALSSVVCLGFLVWALVVYATGSPLPGWSSLIITMLFFGAVQLFCLGMLGEYVARIHTAVQGRPTYVVARDTGEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J787</accession>
    <name>A0A0F4J787_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000596">
        <property type="protein sequence ID" value="KJY30035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30035">
        <property type="protein sequence ID" value="KJY30035"/>
        <property type="gene ID" value="VR44_21380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.149"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="46438" checksum="CA1C1BF1D133ADC9" modified="2015-06-24" version="1">MAASVLLADAALAAKRAGAGLTEALTGAGSALQALRRPTWALGTALSCVRALTDPAGLGFGANGGVVGELARIAGNVTRRRPAAVAMAVDAFALRIEAATVTHPNLDSPHARRLTGALVAGDRLEAARALHALVERLGITRALTTVSPVIMELLALTGLLDENPVNDEFSWVTLAGGVPTTDPFLGLPSSLLKYLNPGPGRAERAEPDPILAKVLGTSGNDIVSYINDIGALGNHGLVLLRRVSCADGAVRHVVLLPGTSFALLSNSTPQDLIGAFDGLLRTDTTYTRAVKKLLLRAGVPAGSELMLVGHSLGGLTAMNLAADVDVASEYRITHVVTLGSPIDNKRPADHTTRVVSLVNKHDVIPTLDGRGPASPNDIPDDWVELAWLDESYDYPLSHAPQAYSDSLRGELGHHRERINDLIRRYDGEITANQPYMLRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7G0</accession>
    <name>A0A0F4J7G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C4-dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_20760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949052.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000572.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1393"/>
    <dbReference type="EnsemblBacteria" id="KJY30332">
        <property type="protein sequence ID" value="KJY30332"/>
        <property type="gene ID" value="VR44_20760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8870"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="455" mass="46626" checksum="4A61E74D2050FE64" modified="2015-06-24" version="1">MAARRDRTHYLYIAVIAAVLLGIVVGFAAPGTAVELKPLGTGFVNLIKMMISPVIFCTIVLGIGSVRKAAKVGAVGGLALGYFMVMSTVALAIGLVVGNLLEPGSGLHLTEAARHAGEAQAKAGGAQSTPEFLLGIIPTTLVSAFTGGQVLQTLLVALLCGFALQAMGPAGEPVLRGIGHVQKLVFRVLAMIMWAAPVGAFGAIAAVVGATGIDALKSLAVIMIGFYTTCLIFVVVVLGTLLRVCTGVSIFALLRYLGREFLLILSTSSSESALPRLIAKMEHLGVSRPVTGITVPTGYSFNLDGTAIYLTMSSLFVAEAMGKPLALGEQVSLLLFMIVASKGAAGVTGAGLATLAGGLQSHRPELVDGVGLIVGIDRFMSEARALTNFAGNAVATVLIGTWTKEFDRERAAEVLAGRLPFDESVLVDEGHGAAPANTPATLPGPSAGPKDGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Z1</accession>
    <name>A0A0F4J7Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000681">
        <property type="protein sequence ID" value="KJY29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000681.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29051">
        <property type="protein sequence ID" value="KJY29051"/>
        <property type="gene ID" value="VR44_23895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.753"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16997" checksum="E73395FC13B5A982" modified="2015-06-24" version="1">MTLSHPHLPTTESAVRAIREIAEEYRLTCTVSEDIGADRTSRRTAADAFGALDPDGTLPHEAFVELDGTPAVGVRLYAEDDARITVDHVEFHDVPRDAVPAFLRSVYGGLAHTRGRFFPPGLWLVVPLPGDTVYKELVTSLHPTPWLLRNSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J833</accession>
    <name>A0A0F4J833_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_23685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949598.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29106">
        <property type="protein sequence ID" value="KJY29106"/>
        <property type="gene ID" value="VR44_23685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.682"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY29106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="37628" checksum="1CD38403AAF1C214" modified="2015-06-24" version="1">MQPHARDDAPGPATAAAPSDPGTAYAISTRGLAKSYPGPDGTATHAVRGLDLDVHQGETFAFLGPNGAGKSTTIALLCALTRPTAGRATVAGTDVLGRPDRVRRQVGMLFQHSALDMDLTAEQNLHIHARLYGMGRRHARRRATEALEAVALAGRRRSPVRTLSGGMRRRLELARGLLHEPRILFLDEPTTGLDPHARAQVWEHLRTLRDRQGTTLFVTTHYLGEAENCDRLAIIDGGRLVAQGTPRALKAAIGDDRVVLRTGDDPAAREIVRGAVPPRTPTTLDGEGIALRVPDGGSWIPRLCAALADHGIPVHAASATPPTLDDVFFHHTGRSIRGARPGAHATTTPAEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8F0</accession>
    <name>A0A0F4J8F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5732"/>
    <dbReference type="EnsemblBacteria" id="KJY30064">
        <property type="protein sequence ID" value="KJY30064"/>
        <property type="gene ID" value="VR44_21300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8985"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="2">
        <location>
            <begin position="85"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="22408" checksum="FCDCAF377417F40E" modified="2015-06-24" version="1">MFEPRTCGTSAAATGYRRGVSADPPQRAVEVRRSARRRRTVSAYREGDRTVVLIPARMSEAEERRWVGVMLDKLAAQESKRTLGDAELTERAARLSEQHLSGRARPRSVRWVTNQNTRWGSCTPAEGSIRLSHRLQGMPEYVVDYVLLHELAHLLVPGHGPRFWELLEAYPKTERARGFLEGVVAAERLPRIPAAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8P4</accession>
    <name>A0A0F4J8P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000539">
        <property type="protein sequence ID" value="KJY30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30762">
        <property type="protein sequence ID" value="KJY30762"/>
        <property type="gene ID" value="VR44_19535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8517"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="32624" checksum="25A016805DFB5DCD" modified="2015-06-24" version="1" fragment="single">MTGAGRYLVTRGETLHAHEIRSGKEVWERPVTFGRTNPVLLVGEGRILVQTHDALVLCSLDDGRTHWIDRTLHTRNTTVLELLAVGGDTVWLHLGPAAGASATTHALAAFDLAARKELWRSELPADFVYELSLTPTPAGLLVEVLPEVDPHRDPYGTRKVPLACFDRATGRSLWQRTYEGVYSGPASAVDETGRFYVLSTGRARAYDATSGNQLWESTLRFDGQHSPLLLAGTLLCETDPVNGVVALDRDTGRKVWQQRLDEPLQWFLLGTMATSASGRTLFVPTRRQLAALDLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8Y5</accession>
    <name>A0A0F4J8Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000549">
        <property type="protein sequence ID" value="KJY30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30650">
        <property type="protein sequence ID" value="KJY30650"/>
        <property type="gene ID" value="VR44_19920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22042" checksum="B1A20032EA7E9BE8" modified="2015-06-24" version="1" fragment="single">PRHRLAEGVARQLEEAGFGAVGAEEARTAARHYAWWTGHSSVTPERVAAEADAVLAALAGADVVAAVLLARTAAPAFAASLHWDAWERVLRAGAEAARKAGEVAEQAYFHHELGVLALCEGRLDRARAELEASIGLRGALADKRGTVAGRRALALVTDREALGAAASPPLRLEAPSTPGTTPPPPAGGSTRTPFPPVGGPNAPATPPSAAGSNAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9E1</accession>
    <name>A0A0F4J9E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949037.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6946"/>
    <dbReference type="EnsemblBacteria" id="KJY30378">
        <property type="protein sequence ID" value="KJY30378"/>
        <property type="gene ID" value="VR44_20655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8846"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23256" checksum="B1D5852FAD880CDE" modified="2015-06-24" version="1">MPVTVLLVDDEPLVRAGLRAVLESQPDIEVVGEAADGASVIPLVRQLRPDVVAMDVRMPLLDGIEATRAVLRSVDSPPKIIVVTTFENDEYVYQALRAGADGFLLKRARPAEIVHAVRLVAEGETLLFPSAVRSLAAEYGNRQARAALERAALTEREEAVLRLMARGLTNVEIARELIVGTETVKSHVSAILGKLGARDRTQAVIAAYESGFVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9G8</accession>
    <name>A0A0F4J9G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000629">
        <property type="protein sequence ID" value="KJY29616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29616">
        <property type="protein sequence ID" value="KJY29616"/>
        <property type="gene ID" value="VR44_22450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.379"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7025" checksum="965B4EBEFF7DEA3F" modified="2015-06-24" version="1" fragment="single">MQLVRGGPAGADQVRVGQRLPGMVGQPGDVAHGVGVDDPHQQPVLRARAGRFQQHQAAPVRGEAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9L2</accession>
    <name>A0A0F4J9L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30484">
        <property type="protein sequence ID" value="KJY30484"/>
        <property type="gene ID" value="VR44_20360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8781"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="53"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="191"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="35388" checksum="2449DFFA19955B3C" modified="2015-06-24" version="1">MSYEVVHRRVRPMSAPATPRRTSSAPNPAVSSAPPRGSRRTGALDWRVRFAFLSVVWGFSFLFIKVGTGAFAPFQVALGRVFFGALALLAVLLVRREPLPRGRRTWGHLAVAALLLNTAPFALFAYAEQTVTSTLAGICNATSPLWGMALSLVALSEDRPTRRRFAGLGIGFLGVLTVLGAWQGFTGVDTKGTALALLASLCYPIGWIYVRRTLAGTSGSPVAMTGAQLMVSTLQLAAVSSLFTSAPAAFPLWPTLAVITLGALGTGAALQMQYGLVTEIGPTTAQMVTYFIPVIATTAGVLVLGEQLHWNTPVGALIVLAGAALTQARPQPAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9U1</accession>
    <name>A0A0F4J9U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949324.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29746">
        <property type="protein sequence ID" value="KJY29746"/>
        <property type="gene ID" value="VR44_22185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.321"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="33658" checksum="C72182311BDD4159" modified="2015-06-24" version="1">MDSPHGAVVKAEGFGLKGPRGWVFQDIAIDAAPGSLLAVEGPSGSGRTCLLLALTGRMKPTAGHAEVGRHRLPKKMAAVRRITALGPVPGVNDLDQALTVAEQLREGAMLQRRYDAPVRALLRPRGAHAPAPARVRIEQALAAVGLDPATLPKGMRTSVRDLERLEAIRLSVAIALLGGPRLLALDDLDLKLSDTERTEAWDLLRSVAARGTTVLAVCSEAPADVTVVRTGPQAPAEPAAEPAAAPLSETPKVTWGTSRPEETEAQAAPAAPSLTKKDAAPAAAGTGSDAVDDDEHEHEHEHEDEDEDTKGADDALAETGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA80</accession>
    <name>A0A0F4JA80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000608">
        <property type="protein sequence ID" value="KJY29881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29881">
        <property type="protein sequence ID" value="KJY29881"/>
        <property type="gene ID" value="VR44_21760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.232"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="54" mass="5664" checksum="1C725E0265F51D14" modified="2015-06-24" version="1">MDYVSALVPPIVMATFFIFLVRTIVKSQGGANKAKEDAAVDAVLARAEAGQPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBT3</accession>
    <name>A0A0F4JBT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000476">
        <property type="protein sequence ID" value="KJY31660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31660">
        <property type="protein sequence ID" value="KJY31660"/>
        <property type="gene ID" value="VR44_17675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8033"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="13033" checksum="C936371AFD2CDF38" modified="2015-06-24" version="1" fragment="single">GGIAVYTAIVTVALLAVIGLAIDGGGKLRATERADALAMEAARAAGQAIDPASAVTGTDVRVDPEGAQAAAQAYLARAGAHGSATLSADRSRLDVTVHGSYPTVFLAIAGIGSMGVTGHGSARMLHGITQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCK6</accession>
    <name>A0A0F4JCK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948862.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000544.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30721">
        <property type="protein sequence ID" value="KJY30721"/>
        <property type="gene ID" value="VR44_19710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8560"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="290" mass="31186" checksum="DC03E623BF1BA121" modified="2015-06-24" version="1">MAEGDVGTGIRPWRNWVVTLATLVAPTTFIGALLLYFGYAYTDALYEHFGVDAATLGFSTQDYALRSAGALYIPAGTALTVALAGVLVYYAARTVGSRGTPGPPWLRLTPYLLSAGGAVLFVVGMLGGFGAWEAGAMDTPLLLGSGLVLIVYGRVLAFRLADAAYPVARERLALALVVALVGLCSFWAAHAYAKEHGDDDARYLAHHLWLRPAVTLDTVERLYFPPGQVRETRLPPSGTPQRFRFRYEGLRLLAEANGRMFLIPEDWATRGGSVLIVPANDTVRVALSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD98</accession>
    <name>A0A0F4JD98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000433">
        <property type="protein sequence ID" value="KJY32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32180">
        <property type="protein sequence ID" value="KJY32180"/>
        <property type="gene ID" value="VR44_16425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7682"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="5">
        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="406"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="695"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="793" mass="84414" checksum="3D053681233B9404" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDQ0</accession>
    <name>A0A0F4JDQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000457">
        <property type="protein sequence ID" value="KJY31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31888">
        <property type="protein sequence ID" value="KJY31888"/>
        <property type="gene ID" value="VR44_17225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7978"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="94" mass="9965" checksum="300766B70E69CFFF" modified="2015-06-24" version="1" fragment="single">MSRALLVMAHGSRDPRHAATVHALVGRARSLRPGLRVETAFLDFNGPTVSQALASLYLSGVREVVALPLLLTRAFHAKADVPAVLAESATRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEJ1</accession>
    <name>A0A0F4JEJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000404">
        <property type="protein sequence ID" value="KJY32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948111.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32610">
        <property type="protein sequence ID" value="KJY32610"/>
        <property type="gene ID" value="VR44_15710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7544"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="41168" checksum="BF7758BA7051C11C" modified="2015-06-24" version="1">MPAPASAPDLTSTQPRPVYVIGAGPGGLAVAAALRARGVRAVVVEKSDAVAASWRGHYERLRLHTTRRLSALPGLAMPRRFGRWVARADVVRYLEKYAEYHELELVTGVEVTRIERAADGEGWTLHASGGRLLAAGAVVVATGFNHTPHLPDWPGSATFTGRLLHASGYREPSPYAGRDVLVVGVGNTGAEIAVDLAEGGAARVRLAVRTAPHIVRRSTLGWPAQRTGILVRRLPVRLVDRLGALVAKASVPDLSAYGLPRPAPGLYSRARQGAIPVQDVGLIDAVRAGRVEPVAAVASFDGDRVLLADGTEITPDTVIAATGYRRGLEALVGHLDVLDDRGRPRVHGPRSAPHAPGLYFTGYTNPISGMFRELARDARRVAKALAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEM2</accession>
    <name>A0A0F4JEM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32645">
        <property type="protein sequence ID" value="KJY32645"/>
        <property type="gene ID" value="VR44_15495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7500"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="12251" checksum="CA6E273B935746B0" modified="2015-06-24" version="1">MTSATVAVPVQVVPFPPGASLTAPSAAEDTVRFFDPAGAVTVTLMASPGFTGEEGTVTDAPAAGVLVEGEGDGVPAAKAVLAAPPPTASAEARAMDERVRTVRALRMGSPPERAAGVFPAHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEU4</accession>
    <name>A0A0F4JEU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948004.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000387.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32872">
        <property type="protein sequence ID" value="KJY32872"/>
        <property type="gene ID" value="VR44_15135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7445"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25456" checksum="6AEA5D11E2D95D60" modified="2015-06-24" version="1">MAVALPAVYDAFDLPRTELAARALRYAEEAEPAVIFRHSVRSYLFARALADHDGMKPGADFDDELVFLGCVLHDLGLSQPGNGDQRFEVDGADLAARFLREQGTDEHSVTVVWDAIALHTSEGIASRKGPEIALAHAGISVDVLGRGRERLPEGFADRVHTAFPRADLAYAITDVIVQQMLDNPAKAGPLSFPGQLLRRHLPAGTLPDWYDLIEGAGWGDRPTTGLPGLAVVRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFC0</accession>
    <name>A0A0F4JFC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947984.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32910">
        <property type="protein sequence ID" value="KJY32910"/>
        <property type="gene ID" value="VR44_14975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7411"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="31239" checksum="CB3FDADD6A7131BF" modified="2015-06-24" version="1">MKTSRIHAFGDASVISYDDVPRPRPDSGEVLVRVAATSFNPTEAALRAGLLQAFLPVELPYTLGWDVAGTVAEIGPGAGRFAVGDRVVGRLEGAGAAAEYVRAPGALLVPAPASVPLPHAATLPVAGLTAWQAVFEHGKVTVGQRVLVNGAGGGVGGFVTQLAKHAGAEVIATAGARSDRAVRRHGADHVIDYTAAPVPAALDGPVDTLLNLVPLSPDDAAGLASVVRPGGRIVSIATPIDPPADAGVTAMHMVARNDVAHLAALVDLVDAGEVTLDISASYPLSDLADVHRLSEAGRLRGKVVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFS4</accession>
    <name>A0A0F4JFS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948418.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31836">
        <property type="protein sequence ID" value="KJY31836"/>
        <property type="gene ID" value="VR44_17355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8007"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="35519" checksum="5B35FDDACCB5D8C6" modified="2015-06-24" version="1">MGIESDHLVYEYLSRVGDLAQQRQLPSGDRMRLRLVSGLRDEIDRRRARFEPETPEAVRAVLERLGTPEEVLDAVGRRAAQAGAGPVADPGRAAVAPVSVPQQRGNRRRAAAPAPEPRNVPPHLAGLDELGGSSSDHGEPDWWRLPAAGRGPQVEGFAGGIEIPELLGRDTEEEPATGPAPATPPQGAAAGLLGYLKQRRERGKEPQPPAPGAAEAGPAAKVPRPRPHGFLLLAAVLLGAGALTGYWPLLGAGALVAYVSRVLGPRERKWVILGVPAGVFTAAVLWLWGRSTGRWGEPLPSAQLGPAFQAMWPTLARTAGATLAAYLAWRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGB4</accession>
    <name>A0A0F4JGB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_15220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000393">
        <property type="protein sequence ID" value="KJY32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32798">
        <property type="protein sequence ID" value="KJY32798"/>
        <property type="gene ID" value="VR44_15220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="828" mass="87865" checksum="0763732AF264BF69" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGJ8</accession>
    <name>A0A0F4JGJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine/putrescine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000439">
        <property type="protein sequence ID" value="KJY32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32091">
        <property type="protein sequence ID" value="KJY32091"/>
        <property type="gene ID" value="VR44_16605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="17105" checksum="6D7FA1427F4778AB" modified="2015-06-24" version="1" fragment="single">MSTTLTEAGKPAQSAATGGARVEFRGLRRAFGTTTALDGLDLTVEPGELLALLGPSGCGKTTALRVLAGFEHPDSGEVLVDGQDITRVPANRRDAGMVFQSYSLFPHLDARENVAFGLRVRGVPAARRRERAAELLDLVGLPEHGDRYPHQMSGGQQQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGS7</accession>
    <name>A0A0F4JGS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_16430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000433">
        <property type="protein sequence ID" value="KJY32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32181">
        <property type="protein sequence ID" value="KJY32181"/>
        <property type="gene ID" value="VR44_16430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7683"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="505" mass="52916" checksum="D2501FF281944434" modified="2015-06-24" version="1">MFAAVLGAPRAWADTHLIHSGGDSLAAVRIAHRLTLAAGRRVTAADVLSSPRVFELAALLPELPPVSGAEPGAAAEPELSAGQIRIWLTEQLAPGCPQNLVQRTTALDGPLDIEALRAALGDVVDCHPVLRTVYLEDEDGVPFQRILPPGGIPPLEEIRVPAAELPARARAFATAPVDLTTGPVLRLGVLHDPEVPGRATAVLAVHHIAVDGWSLPVIVEDLRSAYEARSRGEAPVLPAEAVGYAAWHGAEAAAADPAERERRLRAWREELAGVQDVPPTAPPATAGSAGGGEVGVIPAPVTPGAAAVVRDLARSTEATPAVVLLAVFAQAVSDITGARRFCVAVPVAGRSDPRLERTVGFCVNTVPVRVDTEPGADPLPLVPVLRRRFLRALRDELPFNDVVAAAGGDRGHRMPLVQVCMAYQTDADATLTLPPARSQPEPTPAGDGGFELTWELRPHHPAAADDGITGTVQFRTGAFPAATARSLRERLGALLGALDVRCSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH39</accession>
    <name>A0A0F4JH39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33505">
        <property type="protein sequence ID" value="KJY33505"/>
        <property type="gene ID" value="VR44_13775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7033"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="19868" checksum="ACD914F51085D5C5" modified="2015-06-24" version="1" fragment="single">MESILQAAGELVGGELSGPVDLGGSSRSTVLRCRTAGGGSVIVKAFGNEPESLRCFTAEAAGLSLGISAPEVLGVDPKVPLLVMADLGNAPTLADVLLGNDPALAENGLLAWARALGALAAGSVHRRPDLARLWSRYDKGMPSWEDEPWTARNAAALPALLDGAGVRPPAGLDEELSRIGTAGGDVHPAFTPGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ28</accession>
    <name>A0A0F4JJ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33819">
        <property type="protein sequence ID" value="KJY33819"/>
        <property type="gene ID" value="VR44_13200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6858"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="289"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="40187" checksum="A6BDBB20982D8B74" modified="2015-06-24" version="1">MRADPRRQDLGLALLVQLASTIPFVVPRDPADSPATWTAYLLTTLGNVPLLWRRRAPVAALLGVLVAGSVYRLALDGPGQPLPYAGLVCVYSIALLRPARERLAVAAALVVVIAVSVGLNTGTARELLFSLFVFAAAFALGRLQETRLAYTAAVEDRAAQLERANRIEAEQAAARERARIAREMHDILSHAVSIMVVQAEAGPVAVRRAPERAEAAFEAIAETGRDAMAQLRTMLGVLRTQETAPGQEAAPRAPQPGIGALAALVDRVRASGLAVSYERTGEVRELPAALETTVHRVVQEALTNVVKHAGAAAVAVRLEYGPRELAVRVTDDGRGPAGGAAGGHGLIGIRERAAAHGGTAWTGPGPDGRGFTVLVTSPLEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJZ9</accession>
    <name>A0A0F4JJZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_12575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947541.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34093">
        <property type="protein sequence ID" value="KJY34093"/>
        <property type="gene ID" value="VR44_12575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6580"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="24841" checksum="EB0519F9D72C52CD" modified="2015-06-24" version="1">MRVLVVEDERRLAAALQRGLQSEGFTVDVAHDGPQGLWMACEHDYDLIVLDIMLPGLNGYRVCARLRAAGNESGILMLTAKDGEYDEAEALDTGADDFLSKPFSYLVLVARLRALARRTGRRGPQALRLGDLLVDPARHLCSRGETEIRLTAREFAVLEYLARRPGEVVPKREILEQVWDSAFDGDPNVVEVHVSAVRRKIDAPFGRSSLETVRGVGYRLAADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL60</accession>
    <name>A0A0F4JL60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000244">
        <property type="protein sequence ID" value="KJY35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947229.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000244.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35082">
        <property type="protein sequence ID" value="KJY35082"/>
        <property type="gene ID" value="VR44_10875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6055"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="17324" checksum="98B54601CDEE9684" modified="2015-06-24" version="1">MQIAGDILAVQHLLQPAREHPVTVAEFAGLARSIAEDRASWEHLVQYDATTRWYHRLRTGPGYEVWLLSWVPGQGSGLHDHGASSGVLTVLDGELTEHTPRGRLTHRAGAQRVFAPGYAHEVVNDTLEGAVSLHVYFPGLTEMPMHSCSPAHPEHVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JML5</accession>
    <name>A0A0F4JML5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_09745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947017.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35607">
        <property type="protein sequence ID" value="KJY35607"/>
        <property type="gene ID" value="VR44_09745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5449"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470667" description="Histidine kinase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="266"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="487" mass="51894" checksum="59C4F09BD66297E8" modified="2015-06-24" version="1">MPSRAPFGLRTRLIAAFLLVAAICAVSTAALTYRQARSAVLTQSQDTAVSTLRDQLETVALTLPLDQRQLQRVVDEVGRRGKPHPWVVFGEYGTLRASSADLGSPVSDVLTDTLRSQVSTHPHGAFQRVTDDRGEPYLTIGMPAVFLHNGAREATGAVLYAVMPLSTEQQTVDAMVQAAKQGAVPGLAISVVPALLAARSVLRPVRDMRRAAQNLGRGRLDTRIEVRGADELAGLARTFNETAGALEESVAELREAEARARRFAADVSHELRTPLAGMLAVTEVLDEDAEQLDPDTAKALRLISAETGKLAVLVEDLMEISRFDARAAGLNLDDVDVAEAVGKTLQRRHWDDERVSTDLPEGVRARLDPRRFDVVLANLVGNALRHGAAPVRIGVRTAPAPEGERLVVEVADSGPGIAPEVLPHIFDRFFKADAARARSAGSGLGLAISLENVRLHGGTLSAANAAEGADGFGGAVFTLDMPLEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN37</accession>
    <name>A0A0F4JN37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947015.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35605">
        <property type="protein sequence ID" value="KJY35605"/>
        <property type="gene ID" value="VR44_09730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5446"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="25674" checksum="E7F7C0C2D5C875D6" modified="2015-06-24" version="1">MNDDVRNIVLGVVATAISGGSGWFTRTYLWRRALRRKQAFFGLPTGSDCLFVVNRQMGGTESSLHRNDAFALLEISALIKDCGATVQIVTHEARQGFGERAEFCVGGPASNSRTVAHLHSMLPGVRVDLSAEAGPDRGAITIGGEAYRWEPGLVEYVLLARLTSGQGSRPVFLLSGQTAISNLAAARYLARHHEKLARTYRGASFCLVLKVVNSEAYGPDVTELVSDVTAAARTPAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP07</accession>
    <name>A0A0F4JP07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007264399.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7054"/>
    <dbReference type="EnsemblBacteria" id="KJY35574">
        <property type="protein sequence ID" value="KJY35574"/>
        <property type="gene ID" value="VR44_09850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5516"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9833" checksum="797A67917346555C" modified="2015-06-24" version="1">MNRSELVAALSERAEVTRKDADAVLAALAETVGEIVAKGDEKVTIPGFLTFERTHRAARTARNPQTGDPIQIPAGYSVKVSAGSKLKEAAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP09</accession>
    <name>A0A0F4JP09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000271">
        <property type="protein sequence ID" value="KJY34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947344.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000271.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34676">
        <property type="protein sequence ID" value="KJY34676"/>
        <property type="gene ID" value="VR44_11515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6205"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="28339" checksum="477D8470CE406F98" modified="2015-06-24" version="1">MKLWLLNHLPTGWLAALVVGGIILLALVGSMLATRFFPVLAAGENNDMVGVVLGMFGAIYGIILAFVIVNLWTDLQTARTVVAAEASAVSQIVRDAEAFPPGTRTAVHDRVDNYVHTVVERQWPMMQVGRGDAAVTSQAVDDLYRVLAAYEPRSFSAQAFYQEALDSLNEVAAQRRARISQSHDELPALLQVLIYGGAAVIVLITLLYGVRDRRVRLLFVGSVAALIGFSLLLVIVLDCPFAGDMSVSPQPFKASALARFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPU1</accession>
    <name>A0A0F4JPU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_11155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000252">
        <property type="protein sequence ID" value="KJY34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947278.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000252.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34921">
        <property type="protein sequence ID" value="KJY34921"/>
        <property type="gene ID" value="VR44_11155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6115"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24086" checksum="B7D712E9F44DB117" modified="2015-06-24" version="1">MPLTPTERDRLLLFGAAELARARRARGLRLNVPEATALIADTVCEAARDGVRLAEALQRGRSVLGPDDVLPGVVDIVTEVMVEAVFEDGTRLAAVGDPFGARPRDDEAPGAVLPGADTVDEPEPALTLAVRNTAAVPVSVTSHFHFFEANPRLDFDRAAAYGMRLAVAAGSSTRFDSGAVVEVGLVPIGGARIAIGFAGLVDGPLDAPGAKAEALRRAVACGYLGAVAPEGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRI5</accession>
    <name>A0A0F4JRI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_07150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30763"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946530.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4613"/>
    <dbReference type="EnsemblBacteria" id="KJY36810">
        <property type="protein sequence ID" value="KJY36810"/>
        <property type="gene ID" value="VR44_07150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3774"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043837">
        <property type="term" value="F:valine dehydrogenase (NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="13">
        <location>
            <begin position="152"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY36810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="369" mass="38699" checksum="BB7B43E8D3354D09" modified="2015-06-24" version="1">MTEMTDGVLHTLFRSEQGGHEQVVLCQDRATGLKAVIAIHSTALGPALGGTRFHAYASDEEAVRDALNLSRGMSYKNALAGLDLGGGKAVIIGDPANLKTEELLLAYGRFVESLGGRYVTACDVGTYVADMDVVARETRWATGRSPENGGAGDSSVLTAFGVFQGMRASAQHLWGDPTLRGRKVGVAGVGKVGRHLVEHLLEDGAEVVITDVREESVREILDKHPGGKVTAVADTEALIRTEGLDIYAPCALGGALNDSSVPVLTASVVCGAANNQLAHPGVEKDLADRGILYAPDYVVNAGGVIQVADELHGFDFDRCKAKASKIFDTTLAIFARAKEDGIPPAAAADRIAEQRMADALAARAAARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSH1</accession>
    <name>A0A0F4JSH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_05975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946313.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2624"/>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="EnsemblBacteria" id="KJY37317">
        <property type="protein sequence ID" value="KJY37317"/>
        <property type="gene ID" value="VR44_05975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2409"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="239"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="528"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY37317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="848" mass="93704" checksum="6530AA1505C6BC18" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSR9</accession>
    <name>A0A0F4JSR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">VR44_07210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946536.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36808">
        <property type="protein sequence ID" value="KJY36808"/>
        <property type="gene ID" value="VR44_07210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3783"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16105" checksum="000A9044A80DA261" modified="2015-06-24" version="1">MTRPVPGAEAIDPDVDLHVPAQRTEPQGRVLAAVAAGGAVGASARYGVALLWPAGPAGFPWATFWTNVAGCALIGVLMALISEEGRRSPHPLLRPFAGTGVLGGFTTFSAYAVDFSRLLDAGRAGLALAYAGLTLVAALGAVWAAASLTRLALRGRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT30</accession>
    <name>A0A0F4JT30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36969">
        <property type="protein sequence ID" value="KJY36969"/>
        <property type="gene ID" value="VR44_06725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3424"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10394" checksum="DAB7B14C570FFF29" modified="2015-06-24" version="1" fragment="single">CSGSGTDFSRWQGSTAPVGGVPALPTARRSSSVPTPPPALGNVTVSGFSSAIMGIFPLLTRKEISLPDRFPRHLFGGDPAALDAVWREWWDLDLAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUL5</accession>
    <name>A0A0F4JUL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_05695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946259.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M04.025"/>
    <dbReference type="EnsemblBacteria" id="KJY37428">
        <property type="protein sequence ID" value="KJY37428"/>
        <property type="gene ID" value="VR44_05695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1954"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="78"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="189"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="38422" checksum="3160287C8FF98E09" modified="2015-06-24" version="1">MDAFLPHGHAPHHPVFCTVVPPHLLDKAARSADTARADAAQRTLETDALLRTRRRISTVRGIVPAEADASAPEGPRRTIYDAQHHTRLPGKKVRAEGADAAKDATVNRAYAGLGATYELFLKGYGRRSIDGSGLPLDASVHYGEDYNNAFWDGQQMVFGDGDGDLFLDFTVSVDVIGHELTHGVTQYTANLDYHGQSGALNESMSDVFGSLIKQYSLGQTADQADWLIGAGLLGPNVTGVALRSMKAPGTAYDDDELGKDPQPATMDGYVTTSRDNGGVHINSGIPNHAFYIVATELGGKAWERAGQIWYDTLTGGQLESRADFRDFARLSVAAAVARYGEGGAEHQALQKAWAAVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUP0</accession>
    <name>A0A0F4JUP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37900">
        <property type="protein sequence ID" value="KJY37900"/>
        <property type="gene ID" value="VR44_04680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="38"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="6">
        <location>
            <begin position="573"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY37900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="765" mass="80546" checksum="7BFC9871B475E210" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVS1</accession>
    <name>A0A0F4JVS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37858">
        <property type="protein sequence ID" value="KJY37858"/>
        <property type="gene ID" value="VR44_04795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1039"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="20961" checksum="9A67B5907D52D73A" modified="2015-06-24" version="1">MAYDEWERAGHQLVGVLDSSCWWLGDWLKYGKDHYTDRYQRGIRAAGLSYQTLRNYAWVSRRFDLARRRPALSFQHHAELASLPAREQDLWLDRAEQRQWTTKQLRAALRATRQGGQPARTPAEPSRRLEVPGSRVQWWHKAAQQQGVDFEQWVMAALDSAAASALEEPADREEQKESVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVS4</accession>
    <name>A0A0F4JVS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000120">
        <property type="protein sequence ID" value="KJY37071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37071">
        <property type="protein sequence ID" value="KJY37071"/>
        <property type="gene ID" value="VR44_06610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3240"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="123" mass="13289" checksum="66816624DC1F979A" modified="2015-06-24" version="1">MIAVETQVVRVLGPERTRSPSMPRAKKISEPAPLVGDRLLTPAETARRIGIVPGTLRNWGTAGKGPRRYRMSPDFGGRVRYSEHEVDAFVEAVKAGELARPPKSPATSVRSRAEDAQTGDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWD8</accession>
    <name>A0A0F4JWD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">VR44_04065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000075">
        <property type="protein sequence ID" value="KJY38159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945969.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene733"/>
    <dbReference type="EnsemblBacteria" id="KJY38159">
        <property type="protein sequence ID" value="KJY38159"/>
        <property type="gene ID" value="VR44_04065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8718"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="20880" checksum="132BD878B8FCFB99" modified="2015-06-24" version="1">MIEEILLEAEEKMEKAVVVAKEDFAAIRTGRAHPAMFNKIVADYYGAITPINQLASFAVPEPRMAIVTPFDASALRNIEQAIRDSDLGVNPSNDGRIIRVTFPELTQDRRKEFIKVAKTKAEDSRVSIRSVRRKAKDALDKLVKDKEAGEDEVRRAEKELDDTTAKYVTQVDELLKHKEAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX64</accession>
    <name>A0A0F4JX64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_02620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000041">
        <property type="protein sequence ID" value="KJY38947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945704.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38947">
        <property type="protein sequence ID" value="KJY38947"/>
        <property type="gene ID" value="VR44_02620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6830"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16414" checksum="0C1459124647DB6E" modified="2015-06-24" version="1">MPNAIADGLDALTSLSGADLGRTEWLEITQDRVNTFADATDDHQWIHTDPRKAADGPFGGPIAHGYLTLSLIIPLFGELLGITGTRMSVNYGLDKVRFPSPVRVGAKIRLHGVVGTVEEVKGNGVQMPITFTVEVEGGDKPACVAEAVYRHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXA6</accession>
    <name>A0A0F4JXA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuC</name>
        <name evidence="17" type="ORF">VR44_03725</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945903.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000090_gene3540"/>
    <dbReference type="EnsemblBacteria" id="KJY38393">
        <property type="protein sequence ID" value="KJY38393"/>
        <property type="gene ID" value="VR44_03725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8648"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="474" mass="50206" checksum="EBB9AC1F3AC61E74" modified="2015-06-24" version="1">MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRQAGRKVRRLDLTIATEDHNTPTIDIDKPIADPVSRAQLETLRKNCAEFGVRLHSLGDVEQGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVTGELAEGVTAKDLILAIIAKIGTGGGQGYILEYRGEAVEKLSMEARMTICNMSIEAGARAGMIAPDQTTFDYLEGRDHAPKGEDWDAAVAYWKTLRTDEDAVFDAEVVIDGSALSPFVTWGTNPGQGAPLSANVPDPASYEDASERLAAEKALEYMGLTAGQPLREIKVDTVFVGSCTNGRIEDLRAVAGIIAGRKVADGVRMLVVPGSVRVALQAVEEGLDKVFKDAGAEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSDVNATAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY07</accession>
    <name>A0A0F4JY07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946086.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37886">
        <property type="protein sequence ID" value="KJY37886"/>
        <property type="gene ID" value="VR44_04755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1031"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="44377" checksum="0BB9DAA8F6227156" modified="2015-06-24" version="1">MDDYDVIVIGARCAGAPTAMLFARRGYRVLLLEKARFPQDTLSSHYIHMQGVALLNRWGLLDRIRESGATPITHERYEGPGVRIDGFSLPMDGLTTTYAPRRYVLDPILAAGAVEAGVEFREGCAVGDLLWEEDRVSGVRYTTPGGAEATARARLVVGADGMRSLVARKAGAPYVIEHPRATCVYYSYWSGVPSSFELYERPGRWVAAVPTNDDLKLIMTYFPQADYNQVRKDVEPAYLEAVRSTAPDLYERMRGGSREEQMYGTGHQENFFRKAYGPGWVLVGDAVNHKDSITARGITEAFVQAQSLTDLIGDRLHEDAPLRSALRRYENELGNEAHSQYQGALNVAELKPEGRTDMLRRLVGHQEHIDRYFSTLSGAISIDDFYNEELLTLLDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY30</accession>
    <name>A0A0F4JY30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39030">
        <property type="protein sequence ID" value="KJY39030"/>
        <property type="gene ID" value="VR44_02400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6769"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="8218" checksum="9537034EF246E9D6" modified="2015-06-24" version="1">MVADSYRPHPAAAREEGIYVRWLSSHAIVLLVLMFTALFTGVVLPAVWSSRPARRRAAAAVLSEILMTVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ07</accession>
    <name>A0A0F4JZ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(4Fe-4S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_02370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39044">
        <property type="protein sequence ID" value="KJY39044"/>
        <property type="gene ID" value="VR44_02370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6764"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="4">
        <location>
            <begin position="90"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="332"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="5">
        <location>
            <begin position="410"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="506" mass="55244" checksum="D4355964FF51DB2C" modified="2015-06-24" version="1">MPAFPPAAPFPPGATFPPGATSQAFPAFPEAAKEAVRDDVLRANLRRATHTIRDKRARAVTELADWDRLRAAGKAVKDHTLRHLDHYLLQLEAAVTAAGGTVHWAADAEEANRIVTALVLATGEREVVKVKSMATQETGLNEALEAAGIAAYETDLAELIVQLGHDRPSHILVPAIHRNRDEIRDIFRTEMAGWGRPAPEDLGDDPRELAEAARLHLREKFLRAKVAVSGANFMVAETGTMVVLESEGNGRMCLTLPDTLISVVGIEKVVPTFRDLEIFLQTLPRSSTAERMNPYTTMWTGTADGDGPSAFHLVLLDNGRTDTLADETGRQALRCIRCSACLNVCPVYERAGGHAYGSVYPGPIGAILSPQLRGTGSDIDATLPYASTLCGACYEVCPVAIDIPEVLVHLRERVAQGGPVTRAGIRVRLRPAHGHTAERAAMRAARLLLDRPGALRTAERLLARARRLRPRRLPGPGRAWTDTRTLPDLPAEPFRDWWLRERGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZH8</accession>
    <name>A0A0F4JZH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_00500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000006">
        <property type="protein sequence ID" value="KJY39817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945311.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39817">
        <property type="protein sequence ID" value="KJY39817"/>
        <property type="gene ID" value="VR44_00500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.99"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="19504" checksum="10018C98C7C553F0" modified="2015-06-24" version="1">MEDVQREAPRSPAAEALAEAAAETLITVDSPASMQELGRRIAGLLRPGDLVLLTGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPSLGDGPPLVHVDAYRLGGGLDEMEDLDLDVSLPESVVVVEWGDGKVEELSDDRLHVVIGRAVGHEEVLDDVREVALRGVGARWAQAAPELARLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZK4</accession>
    <name>A0A0F4JZK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945453.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4688"/>
    <dbReference type="EnsemblBacteria" id="KJY39545">
        <property type="protein sequence ID" value="KJY39545"/>
        <property type="gene ID" value="VR44_01285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2974"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="29341" checksum="9E2C7F9CF3AE5F55" modified="2015-06-24" version="1">MTHATPHPIQVVAHRGASEDAPEHTLAAYRKAIEDGADALECDIRLTADGHLVLVHDRRVNRTSNGRGAVSALELAELAALDFGSWRDREESPDWDADPERTSVLTLERLLELVADAGRPVQLAIETKHPTRWAGQVEERLLFLLKRFGLDAPPADGPHPVRVMSFSARSLHRVRAAAPTVPTVYLMQFISPRMRDGRLPAGVRIAGPAMRIVRNHPGFIRKLQAAGHSVHVWTVNDPDDVQLCADLGVEAIITNRPRQVLSQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1F3</accession>
    <name>A0A0F4K1F3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsN</name>
        <name evidence="5" type="synonym">rpsZ</name>
        <name evidence="6" type="ORF">VR44_00340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956452.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1036"/>
    <dbReference type="EnsemblBacteria" id="KJY39944">
        <property type="protein sequence ID" value="KJY39944"/>
        <property type="gene ID" value="VR44_00340"/>
    </dbReference>
    <dbReference type="GeneID" id="58435576"/>
    <dbReference type="GeneID" id="61470255"/>
    <dbReference type="GeneID" id="67399245"/>
    <dbReference type="PATRIC" id="fig|68223.7.peg.66"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6963" checksum="BCAAEEA9FCCDB444" modified="2015-06-24" version="1">MAKKALIAKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRVCLREMAHRGELPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1K6</accession>
    <name>A0A0F4K1K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39101">
        <property type="protein sequence ID" value="KJY39101"/>
        <property type="gene ID" value="VR44_02215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5708"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="16449" checksum="0CB3D34CE9923FDF" modified="2015-06-24" version="1">MRRRGTGEAVDGSAPVAEQTRRLVLGGATAGVVTRCRDFTRHALADWRWAPGSEAEEDVLLLVSELVTNACLHAGGPRELVLRHGPGGRLRVEVTDDSPEPPRPRAAQDRSRPGGHGLVLLNHLAQSWGSAPLPDAARPGKTVWLELPSPVPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K207</accession>
    <name>A0A0F4K207_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">VR44_00385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945291.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1045"/>
    <dbReference type="EnsemblBacteria" id="KJY39953">
        <property type="protein sequence ID" value="KJY39953"/>
        <property type="gene ID" value="VR44_00385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.75"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="29861" checksum="58155D37859713BC" modified="2015-06-24" version="1">MVQLKTPEQIAKMREAGLVVAAIHAATREAAVPGATTRDLDMVARKVIADAGAKSNFLGYGGFPATICTSVNEVVVHGIPDDKTVLKDGDIISIDAGAIVDGWHGDAAYTAFVGTGHAPELVELSRVTEESMWAGIAAMKAGNRLVDISKAIEGYIKRQPRPSTGEHSLGRFGIIEDYGGHGIGTEMHMDPHLLNYVSRKRGKGVKLVPGLCLAIEPMVSLGTAQTEVLADDWTVITTDGTWSSHWEHSVALTEAGPIVLTSPDCGKAKLAEYGVTTAPDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ID41</accession>
    <name>A0A0F4ID41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001528">
        <property type="protein sequence ID" value="KJY19935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19935">
        <property type="protein sequence ID" value="KJY19935"/>
        <property type="gene ID" value="VR44_38910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="3">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY19935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8589" checksum="20C27904D6647878" modified="2015-06-24" version="1" fragment="single">EFSRQRGLAADGRCKAFSADADGTGWAEGVGMLLVERLSDARRNGHRVLAVVKGSAINQDGASNGLTAPNGPAQQRVIRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGR2</accession>
    <name>A0A0F4IGR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001483">
        <property type="protein sequence ID" value="KJY20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20859">
        <property type="protein sequence ID" value="KJY20859"/>
        <property type="gene ID" value="VR44_38535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5358"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="3">
        <location>
            <begin position="256"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="445" mass="45953" checksum="5243C9FAFD0AAC73" modified="2015-06-24" version="1" fragment="single">MSRAVAGYTPSMRPGHPGAGAPGRPLVLWLLPVQAALMVGVGLLVTGPLAGQWPLAAEDAVSRGLAAHRGGPALPLSQGLSLLASTSSIIALTVLAVTAMLALSRGRWLREAGFLAGAVAVQSAVFLLVTLLVERPRPHVPQLDAAPPTSSFPSGHVGAAVALFGGLAVLAVLRGRPGLPWLRHALTVALLVIPVLVACSRVYRGMHHPSDVVGGLLNGACTLLVLAHALLLPARTRTAAHTAAVDRPRPRPRPAPGGRQAVVVRHPHGCTPELAERVRHILLRHGYADQVWTQTSAEHPAGALARRIDEVDPALVVACGGDGTVRACADLLAHTGIPLAVVPCGTGNLLAHNLRLDADPATALEAALAGGTARIDLGRIRGDGPRPARFAVMAGAGFDAAMVAGASDRVKRCLGWAAYAVSAVRHLGDPRMRLSIRLDGGPVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJ40</accession>
    <name>A0A0F4IJ40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobH</name>
        <name evidence="6" type="ORF">VR44_38055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01001433">
        <property type="protein sequence ID" value="KJY22040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952252.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001433.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3754"/>
    <dbReference type="EnsemblBacteria" id="KJY22040">
        <property type="protein sequence ID" value="KJY22040"/>
        <property type="gene ID" value="VR44_38055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5177"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY22040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="22341" checksum="DC602C32EA51350C" modified="2015-06-24" version="1">MSEYTVFEYEKDGAAIYRQSFATIRAEADLSGLPASVAQVAVRMIHACGMTDLPQDLGYTPEVVLRARAALHAGAPILCDVQMVASGVTRKRLPAGNEVICTLSDPAVPALAAKMGTTRSAAALEVWRDRGLLENSVIAVGNAPTALFRLLEMIEEGAPRPAAVIGVPVGFIGAAESKDALAAHPSGLDHLIVRGRRGGSAIAAAAVNAIASEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INU4</accession>
    <name>A0A0F4INU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001386">
        <property type="protein sequence ID" value="KJY23697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23697">
        <property type="protein sequence ID" value="KJY23697"/>
        <property type="gene ID" value="VR44_37560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4935"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6147" checksum="5A36337C5C6CCB6C" modified="2015-06-24" version="1" fragment="single">DVAVLVTTSSFTAPAAAYADTCGIVRIDGEALAAWTEEETLPPWEPGASAPAPAQRGSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INU9</accession>
    <name>A0A0F4INU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001385">
        <property type="protein sequence ID" value="KJY23702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952152.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001385.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23702">
        <property type="protein sequence ID" value="KJY23702"/>
        <property type="gene ID" value="VR44_37550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018724">
        <property type="entry name" value="2OG-Fe_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10014">
        <property type="entry name" value="2OG-Fe_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="27320" checksum="9DC6FF1ED17E3A5C" modified="2015-06-24" version="1">MDEENGSGRAAGGSGEAVRAVAEARRMVASRGWYLMPPAVLSRCLGVAPAEWARLDGHWEDLAADPYAAEKGTSRLRRYGQFLLSRQAGGITPLPHEVFVQPDDSNPLYVDVERRFEPLTDAFRAEPVLGALIRLLGEVAAGLDDADEWIVRVHPFRVVARSGSLGQPTPEGRHKDGVTLVSSLLAGRRNVTGGRSTVYDAEGREIAATTLSEPGTLLLSDDRATWHAVSPVRPEDTGRPGHRDVLVTTLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INZ6</accession>
    <name>A0A0F4INZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001373">
        <property type="protein sequence ID" value="KJY23747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23747">
        <property type="protein sequence ID" value="KJY23747"/>
        <property type="gene ID" value="VR44_37415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4902"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9324" checksum="D0DEDB1547A36E9D" modified="2015-06-24" version="1">MRRAGGAGGRRAVAESARASGREAGYGPLRRAGFAAAAGLAAALVTEADRRPRDAFGRLTDPSADGYAWAWLAASAHLTAARRSLVAASWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP24</accession>
    <name>A0A0F4IP24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001363">
        <property type="protein sequence ID" value="KJY23785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23785">
        <property type="protein sequence ID" value="KJY23785"/>
        <property type="gene ID" value="VR44_37285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4849"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AfsA" evidence="2">
        <location>
            <begin position="192"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34409" checksum="A0DE5C675984FA64" modified="2015-06-24" version="1">MPSPAEQHGFRFPSLTATVPKELVHRASVAEVLLTDWQRVDEARFSVTAQWPRSHSFFTPVAGGHYDPLICTETIRQIGSLLGHAEFAVPFGHHFLLWELSLTVHPEHLLVRQTPASLDIDVTCTEIKRRGGSLTGLTYESVVRRDGHVVATGRVSYTCTSPAVYKRVRPPHTLRPDHRPLPLTAPTAPQSVGRLSPTDVVLSPIGEANRWQLRVDTLHPVLFDHPVDHVPGMVLLEAARQASAAALGRSSFLPLGIDSEFKRYVELDAPCMIDAQRLYQDEMPGAEEAVRVTGYQNGAFVFGATVTAASYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ45</accession>
    <name>A0A0F4IQ45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001358">
        <property type="protein sequence ID" value="KJY23799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23799">
        <property type="protein sequence ID" value="KJY23799"/>
        <property type="gene ID" value="VR44_37215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="8874" checksum="9B77E61C05618A5A" modified="2015-06-24" version="1" fragment="single">GERAKGGEGQAPQGPGPRTRQPVAVGDWGTTGVEGVDGFDGDGSDGDTDGLGGGEELTDVDGLGAGGLVGGSGAGDVAGGCGAVVPDGVGVAEAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQB0</accession>
    <name>A0A0F4IQB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001345">
        <property type="protein sequence ID" value="KJY23859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952063.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001345.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23859">
        <property type="protein sequence ID" value="KJY23859"/>
        <property type="gene ID" value="VR44_37045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4796"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="226"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35232" checksum="1947B954CBC5BD7D" modified="2015-06-24" version="1">MPTAHRVVIAVFPDVDLLDVTGPAEVFALANRETAGRAGYEVRLAGSAAGAVRTSAGVRLLTDVAFADVGAEVDTLLVPGAVDMAEDGPVARIDEEVVAWVRETAPHARRVASVCVGAHLLAAAGLLDGRTATTHWSTAAQLAADHPRVTVDPDPIFVRTDHGRLWTGAGISACLDLALALVAEDLGEQTALAVARQLVMYLKRQGGQSQFSVPLSRPAAGRREIDELRLWIADHPDADLSAPALAARMCLSERHFARVFKQETGTSPAAYVEAVRVELARRLLETTDCPLDQVAGTSGLGSAETLHRAFRRQLATTPAAYRRRFRTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR19</accession>
    <name>A0A0F4IR19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001224">
        <property type="protein sequence ID" value="KJY24465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951729.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001224.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24465">
        <property type="protein sequence ID" value="KJY24465"/>
        <property type="gene ID" value="VR44_35270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4165"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045372">
        <property type="entry name" value="YidB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027405">
        <property type="entry name" value="YidB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20159">
        <property type="entry name" value="YidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140804">
        <property type="entry name" value="SSF140804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="11358" checksum="6F5E7231851AF99E" modified="2015-06-24" version="1" fragment="single">IGALAGGGAGGGGQAAGGADNPLGGLLDMLTKSGLADQAQSWIGTGENQPVSGAQIKEALPDDALRQAAQQAGVSTDEAADQLARTLPQAVDKLTPSGRVPTESLEDIIRQQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR48</accession>
    <name>A0A0F4IR48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_36210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001282">
        <property type="protein sequence ID" value="KJY24149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24149">
        <property type="protein sequence ID" value="KJY24149"/>
        <property type="gene ID" value="VR44_36210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4486"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="27158" checksum="2A3C9D4FC9A0A58D" modified="2015-06-24" version="1">MSGDPSAPSPSPILGTGRDPEEDRVHEAAHAPVSEASDVPEPSSRPVIPAQKVLRHSVRGQVLDALRAALVDGELVPGEIYSGPALGERFGVSATPVREAMQQLALEGAVECLPNRGFRVRTRTARSLAELAEVRALIEVPVMLRLARSVPAATWEALRPAALATAEAAAAGDLPAYAEADRAFHRAVLSLADNGQLVQIAEELHRRAQWPLPGAARVRRADLVADAAEHVALLDALAARDLPVVESLVREHFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRF0</accession>
    <name>A0A0F4IRF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_35920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001262">
        <property type="protein sequence ID" value="KJY24249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24249">
        <property type="protein sequence ID" value="KJY24249"/>
        <property type="gene ID" value="VR44_35920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4342"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="3">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid_dh" evidence="2">
        <location>
            <begin position="58"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="30556" checksum="3D91683658572C42" modified="2015-06-24" version="1" fragment="single">VAAPAPVAPAAPAAPVSAGDEGAYVTPLVRKLASESGVNLATVTGTGVGGRMSELRGQTVKMTRMRKVIGDNMMKALHSQAQLSSVVEVDITKIMKLREKAKAGFLAREGVKLSPMPFFVKAAAQALKAHAVVNARINDDEGTITYFDSENIGIAVDSEKGLMTPVIKGAGDLNLAGISKATADLAAKVRGNKITPDELSGATFTISNTGSRGALFDTVIVPPNQVAILGIGATVKRPVVIETEEGTVIGVRDMTYLTLSYDHRLVDGADAARYLTAVKAILEAGEFEVELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRI4</accession>
    <name>A0A0F4IRI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001196">
        <property type="protein sequence ID" value="KJY24602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951656.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001196.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24602">
        <property type="protein sequence ID" value="KJY24602"/>
        <property type="gene ID" value="VR44_34880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4053"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="33217" checksum="A5F5144D5B1072F4" modified="2015-06-24" version="1">MTVFYQLAVTIALALAVCAGAVHYFRTVRAARPPVGVFNGRDIFVIMGFVLALPYVYLALPGGVLPAVLALVFAGGLSVGYRPVIGDGRLRWALIAVLIAGVFAAHLAFGELAAPYWIANSCVVGLVVVSATNLNVQGGMRLRNVAWFLLALTLYDAFFAWVVPLTEELSEAVQGYPFAPAAGLRIGDDLGAVVGMGDLLAYALFTTTAYKAYGKAGLRTGIALVLLFGAVAPVVTLHVVGVVTGHVPAVMPAQVFFGPAAFIGYLLLRRRGPERRMAEIVFGRERLGTPRQAPARTAQAPAAAEPGPAAEVTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRR5</accession>
    <name>A0A0F4IRR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001277">
        <property type="protein sequence ID" value="KJY24168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951899.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001277.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5265"/>
    <dbReference type="EnsemblBacteria" id="KJY24168">
        <property type="protein sequence ID" value="KJY24168"/>
        <property type="gene ID" value="VR44_36175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="263"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="337" mass="35316" checksum="7546E4B46C6F61C4" modified="2015-06-24" version="1" fragment="single">MPEAYIVDAVRTPVGRRGGGLSQVHPADLGAHVLKALVERTGVDPASVEDVVFGCLDTVGPQAGDIARTAWLAAGLPEEVPGVTVDRQCGSSQQAVHFAAQGVLSGTQDLVVAGGTQNMSMIPIAFASRQAAAPLGLTEGPYAGSAGWRARYGDAPVNQFHGAQLIAEKWGISRRDMEEFALTSHRRAVRAIDEGRFARETVPYGDVRVDEGPRRDTTLEKMAGLKPVVEGGTITAAVSSQVSDGAAAMLIASERAVAEHGLTPRARIHHLSVRGEDPIRMLSAPIPATAHALKKTGLTLDAIDLVEINEAFAPVVLAWLKETGADPARVNVNGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRT6</accession>
    <name>A0A0F4IRT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001176">
        <property type="protein sequence ID" value="KJY24730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951582.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001176.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4273"/>
    <dbReference type="EnsemblBacteria" id="KJY24730">
        <property type="protein sequence ID" value="KJY24730"/>
        <property type="gene ID" value="VR44_34475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3876"/>
    <dbReference type="eggNOG" id="COG1485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="372" mass="39354" checksum="0068CAFA51445AFA" modified="2015-06-24" version="1">MSTSLSTSGPASGQPPIADAGPLALCAREPRVPAERLVAEMVPPPRFDSVRFDTYNPDPAQPSQAEAVTVLSGFAAGLGGAHASGAGKRKWFQKKAPAPAAGPRGVYLDGGYGVGKTHLLASLWHATPAEPALKAFGTFVELTNLVGALGFQQTVQTLGGHRLLCIDEFELDDPGDTVLVSSLLSRLVEQGVALAATLAATSNTLPGKLGEGRFAAADFLREIQGLSAHFRPLRIDGQDYRHRGLPEAPAPFSDEQVTKAAYATPGASLDDFPGLLEHLAKVHPSRYGALTDGIAAVCLTDVVPVPDQSTALRLVVLADRLYDREVPVLASGVPFDRLFSEDMLNGGYRKKYFRAISRLTALARDAKPLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRW3</accession>
    <name>A0A0F4IRW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001176">
        <property type="protein sequence ID" value="KJY24732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951584.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001176.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24732">
        <property type="protein sequence ID" value="KJY24732"/>
        <property type="gene ID" value="VR44_34485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3878"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="446" mass="46419" checksum="8316FAF96B224690" modified="2015-06-24" version="1">MSVSRRSLLAAGAVAFTGTLGPLFASGGARASARGYGPLLPDPDGLLDLPAGFSYRVLSRAGDPLRSGEGTVPSNCDGMAAFGAGGGRVRLVRNHENRASATLRVPAVDGLTYDPGALGGCTALDLDPGGGVTAERVALAGTAVNCAGGRTPWNTWLSCEETEDRAGASGYARDHGYVFEVDPADPHRLGAVPLTALGRFAHEAVAVDPYRGVVYETEDAFVRPFGLFYRFLPARPLGGPGSLRAGGTLEALRVPGVPDLSVVDRPGAEFPAEWVPVPDPSAAGTPVRFQDFGPGGITHAQKLEGCYWGGTGVYFVSSYARGSEGAAADHHGQVWFHDPVRARIRLEVRFGPASDISLPGDSPDNICLAPDGGLMVCEDGGGDQYVFGVTPGGEVYPVARNAQDIGKPGAPAWGEFAGVTFSPDRRTMYVNAYTPGTTFAVTGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISZ4</accession>
    <name>A0A0F4ISZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001199">
        <property type="protein sequence ID" value="KJY24583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951667.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001199.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1789"/>
    <dbReference type="EnsemblBacteria" id="KJY24583">
        <property type="protein sequence ID" value="KJY24583"/>
        <property type="gene ID" value="VR44_34935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14664" checksum="27B29DF3A6439C6B" modified="2015-06-24" version="1" fragment="single">MPYRRPPAVQARLDARRDRVLEAAVRLLSREGYAGCSVAAIAAEAGISTGSVYQSFSGKSELAAALFRTLVAREVAAVTAAADRPGTAAERVAGAVETFASRALQAPRRAFALLAEPADPAVDTERLVFRRAFRDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT08</accession>
    <name>A0A0F4IT08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001116">
        <property type="protein sequence ID" value="KJY25140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951369.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001116.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25140">
        <property type="protein sequence ID" value="KJY25140"/>
        <property type="gene ID" value="VR44_33300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="20593" checksum="C43F2870898E84E1" modified="2015-06-24" version="1">MGLLLTLFAASPALAASYRYWSFWQGSGGNWGYATEGPSTARPADGTTLGFRFSVSKDAGAEAAKPRAGADFEGVCGGTAAAEGRKRVALVVDFGVPADAPAGEAPPQEAPRTACAQVAPDATAAEALASVAKPLRYNGAALLCAISGYPKSGCGEPITDEAQPKPSAATAAPSSGGGSGPSAGLLAGAAAVAALGAAAVWQSRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITJ0</accession>
    <name>A0A0F4ITJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_32750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001089">
        <property type="protein sequence ID" value="KJY25340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951266.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001089.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1413"/>
    <dbReference type="EnsemblBacteria" id="KJY25340">
        <property type="protein sequence ID" value="KJY25340"/>
        <property type="gene ID" value="VR44_32750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3362"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="220"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="396" mass="43252" checksum="B487B57139A76413" modified="2015-06-24" version="1">MTATAEELLARTRDLLAAHPPAATAPADFLRARFDAGLAWVHYPEGLGGLGAPRTLQAVVDGELEAAGAPDNDPRRIGIGLGMAAPTILAYGTEEQKHRFLRPLWLGEEVWCQLFSEPGAGSDLAALGTRAVLDEEAGEWVVDGQKVWTSSAHTARWAILIARTDPTLPKHRGITYFLCDMHAPGVEVRPLRQITGEAEFNEVFLTGVRIPDAHRLGAVGEGWAVARTTLMNERVSIGGMRLPREGGMIAPVAAAWRERPGLRTHALHQRLLGLWVEAEVARLTAERLRQQLAAGQPGPEGSGMKLTFARLNQEISGLEVELLGEEGLLYEDWTMRRPDLVDFTGRDAGYRYLRAKGNSIEGGTSEILLNIVAERVLGLPAEPRDDKDTPWKDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITJ3</accession>
    <name>A0A0F4ITJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_32800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001091">
        <property type="protein sequence ID" value="KJY25332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951275.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25332">
        <property type="protein sequence ID" value="KJY25332"/>
        <property type="gene ID" value="VR44_32800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3373"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="39375" checksum="8BC82CAA5A550C9D" modified="2015-06-24" version="1">MLALGTVSLITDVSSEMVTAVLPLYLVAGLGLTPLGFGLLDGVYNGVSALVRLTGGHLGDRLGRHKALAGTGYALSALCKPLLLLAHTLPAIGAVLALDRTGKGLRTAPRDALISLAAAPEDRGRAFGVHRAMDTAGALIGPLLAFLILRGAADGYDAVFTVSACVAALGVLVLVLFVPGRRTEPAPDAAPVSLRASLGLLRRRDLRRTALCALLLGLCTVSDAFVFLLLQKATGIADRWFALLPLGTAGAFFLLAMPLGRLADRVGRRRVFLGGHLALLLAYGLLLTGAHHPALPYAVLLLHGAFYAATDGVLMAEAAGAVPEEHRGGGLALVQTGQALARFAASLGFGAAWTVWGARPALAVAAVLLAVAVAGCARLKPDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUB8</accession>
    <name>A0A0F4IUB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001255">
        <property type="protein sequence ID" value="KJY24281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24281">
        <property type="protein sequence ID" value="KJY24281"/>
        <property type="gene ID" value="VR44_35820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="612" mass="64496" checksum="A57FC5CAB5BD0445" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV85</accession>
    <name>A0A0F4IV85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001058">
        <property type="protein sequence ID" value="KJY25549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818271.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001058.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene260"/>
    <dbReference type="EnsemblBacteria" id="KJY25549">
        <property type="protein sequence ID" value="KJY25549"/>
        <property type="gene ID" value="VR44_32190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3159"/>
    <dbReference type="eggNOG" id="ENOG5033XVZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10420" checksum="6D5B34BC46753C95" modified="2015-06-24" version="1">MILAAEKGDITTIIGGIAPNWGPFGSLGNEAKVMIEVIMAVAILLCLGIAIWGAAKQRIGATALRDTFSAEQGKGLIVAGLTGVFIIGSLGTLFTIVYGMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVG3</accession>
    <name>A0A0F4IVG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001183">
        <property type="protein sequence ID" value="KJY24681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24681">
        <property type="protein sequence ID" value="KJY24681"/>
        <property type="gene ID" value="VR44_34630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24103" checksum="ED2C9BB2941B1564" modified="2015-06-24" version="1" fragment="single">MITRRETHRARLACVLAWGGAAVSWELSTPGPLVPSLASCAAFLILATGCALHTRRGLIAELRRSREIAGATQRVLLRPLPGRIDGLALCAAQLSASRGAAVGGDLYEAVPTAYGVRVLIGDVRGHGLPALGGAAAVLGSFREAAYDEPALGGVLLRMERSLQRHLRERARAEHPSACPSDPESPSSEDFVTVLLLQIAPDGTVLALNCGHPWPYLLRRAVLREPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVN3</accession>
    <name>A0A0F4IVN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001062">
        <property type="protein sequence ID" value="KJY25518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951182.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25518">
        <property type="protein sequence ID" value="KJY25518"/>
        <property type="gene ID" value="VR44_32290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3180"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="22968" checksum="6945FB89D7982934" modified="2015-06-24" version="1" fragment="single">VVNSARSAEAGKELAARLPDAVYVQGDVSDAEDARRIVRAAIDAYGRLDILVNNAGVTRFIPLGDLEAADARAWREIFDVNVVGTWQMITAAVPHLRESGAGAVVNISSVSATRAMGSSVPYAVSKAAVNHMTRLLASQLGPSVRVNAVAPGLIDTPWYEGEEEVWESSREWITENTPLRRVGTPQDVAEATLYLVNAAYTTGDVVTVDGGRHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVP3</accession>
    <name>A0A0F4IVP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ohr subfamily peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951177.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001061.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000005_gene4002"/>
    <dbReference type="EnsemblBacteria" id="KJY25528">
        <property type="protein sequence ID" value="KJY25528"/>
        <property type="gene ID" value="VR44_32260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3174"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="13848" checksum="BDD41A4B5A0B138D" modified="2015-06-24" version="1">MDALYTAVATANGREGRAVSSDGQIDLALAMPPALGGNGQGTNPEQLFAAGYAACFASALGLVGRQAKVDTGDISVTAETSIGQDATGFGLAVTLRIELPESLEGETGALLVKQAHEVCPYSKATRGNIPVELVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW01</accession>
    <name>A0A0F4IW01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_30690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000973">
        <property type="protein sequence ID" value="KJY26187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950886.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000973.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26187">
        <property type="protein sequence ID" value="KJY26187"/>
        <property type="gene ID" value="VR44_30690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2593"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="141"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="375" mass="38575" checksum="00BC95C2EF3EBB4F" modified="2015-06-24" version="1">MRPGARRRARRGRDEPGWPHGAPPPRWARIAPVAALVALCAAQWSTATAELGYFLAALPAVAAFSYGAAGTAFFAVLVLVLLGVPELGVGHARGADLATVATVGLLSVVIAWVRRRRDAQLVSVRTVAEAAQLAVLPPIPERVGGVNCSGLYRAAQQGTLVGGDLYDVRAGPYGVRVVVGDVQGHGLAAVGTVASLLGAFREAVLDDPGLAAVAARLDRRLTADAAADSVAHPELFATAVLLEFPPGLDLVRIVSCGHPPVLLLRDRAVTEVAAEPGPPLGLGLAGPTLPEVAELALLPGDRLLAHTDGVTEARDAAGCFYPLATRVPVLAGDPEGLVPAVWEDLAAFSGGGPRDDVALLLLSPDQRLSGGPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWA2</accession>
    <name>A0A0F4IWA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000953">
        <property type="protein sequence ID" value="KJY26325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950815.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000953.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26325">
        <property type="protein sequence ID" value="KJY26325"/>
        <property type="gene ID" value="VR44_30290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2468"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14396" checksum="3667B8283470F127" modified="2015-06-24" version="1">MYGDQETIRRILTELGDTWAVVGLSNNEDRAAYGVARVLQRFGKRVVPVHPKAETVHGEQGYPSLGAIPFKVDVVDVFVNSTLAGQVADEAVAAGAEAVWFQLGVIDEAAFARTRGAGLEMVMDRCPAIEIPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX77</accession>
    <name>A0A0F4IX77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001097">
        <property type="protein sequence ID" value="KJY25286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951290.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25286">
        <property type="protein sequence ID" value="KJY25286"/>
        <property type="gene ID" value="VR44_32900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3400"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="101" mass="11330" checksum="4FA94D9F65D9F78D" modified="2015-06-24" version="1">MPPWTPSAVLFDNLRYLLNEWDPIGVAGLSQDEYDCMLVPLFQRLRRGATRAELGEFLWYELEDHFGLDPVGHRTDAMADRLIAWWSAVAPAPDTGGTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXB3</accession>
    <name>A0A0F4IXB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000911">
        <property type="protein sequence ID" value="KJY26680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950666.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000911.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26680">
        <property type="protein sequence ID" value="KJY26680"/>
        <property type="gene ID" value="VR44_29480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2262"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="469" mass="51238" checksum="396A20FA3AE5294C" modified="2015-06-24" version="1">MTTFPFAPGPAPTPADRAERGKQARAGLPRSGQARFDPGPDRPDPVEVLLAQAASRVPELVPIRHGRMLKSPFSFYRGAAAVMAADLGRAPRTDLTVQLCGDAHVMNFGLFASPERSLVFDVNDFDETYPGPFEWDVKRLAASLAVAGRDSGFTPQDRAAVVAEAVSAYRRRMRRLAEMRVLDIWYAQDDSEELRLIAAQGGDRVLRRTDRTLAKARSRDHLQALAKLTHRVGGELRIAPAPPLIVPLSQVLGEGGRTDQDTVVRGLIEAYAQSLAPERRVLLARYRPVDVARKVVGVGSVGTRCWIVLLTGRDEDDPLLLQAKEAQESVLAPYTAPADYGSQGLRVVAGQRLMQAASDIFLGWMRVTGVDGRERDFYVRQLLDWKGSIRVETMRPEGLSLFARACGFSLARGHARSGDPIAIAGYLGISDAFDRAVAAYAEAYAEQNLRDYDAFLEAARTGRVATAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY38</accession>
    <name>A0A0F4IY38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein MoaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000924">
        <property type="protein sequence ID" value="KJY26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950714.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000924.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7407"/>
    <dbReference type="EnsemblBacteria" id="KJY26574">
        <property type="protein sequence ID" value="KJY26574"/>
        <property type="gene ID" value="VR44_29735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2326"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="9522" checksum="1AF2E565CAD71C1D" modified="2015-06-24" version="1">MSVNVRIPTILRTYTGGAAEVPAEGATLAEVIDSLEANHPGIAARVLDDQGKLRRFVNVYVNDDDVRFEGGLQTATPDGAGVSIIPAVAGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYM9</accession>
    <name>A0A0F4IYM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">VR44_31650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="JZWV01001025">
        <property type="protein sequence ID" value="KJY25781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951063.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001025.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7091"/>
    <dbReference type="EnsemblBacteria" id="KJY25781">
        <property type="protein sequence ID" value="KJY25781"/>
        <property type="gene ID" value="VR44_31650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3038"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="430"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="874"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY25781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="932" mass="104549" checksum="0DEBEF9580D8723C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYS8</accession>
    <name>A0A0F4IYS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000862">
        <property type="protein sequence ID" value="KJY27180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950445.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000862.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27180">
        <property type="protein sequence ID" value="KJY27180"/>
        <property type="gene ID" value="VR44_28285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1901"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="25273" checksum="51E41E0121A1D547" modified="2015-06-24" version="1">MLAQVSPWYAHAAQRLTTAPAHALTPPARMEWTTHPGLGPGAELLGRDLRGKRLLELGCGPGHNVAHLAHHHKAPTTGVDLIGLQVRRARSHYGHITGTTFSAGHALHHLQATTQTFDAIYSVFGAIGLVPPALLLAEISRHLAPGGVLAFSLPHPARAGRHPSPDDHPREDYVTMPDRTRHPIARWEYDAHRWAAHLSRTGLRITSALDLRHPRLDPWPTTLLITARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYX0</accession>
    <name>A0A0F4IYX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_29505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000912">
        <property type="protein sequence ID" value="KJY26668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950672.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000912.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26668">
        <property type="protein sequence ID" value="KJY26668"/>
        <property type="gene ID" value="VR44_29505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2269"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY26668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="25776" checksum="777D8A4480C746D6" modified="2015-06-24" version="1">MSTDPIGEPPAPEPAEGPGPGTGGERRFEPDLRAMTRITLRPIASPMPLGFFTVAIASVLSGCLQLGLLDTTDRRAVALCVLPAFALQLLVSVLAFQARDVIAATLMGVFAGSWLAYALVLGSGAPGGTRVLGVFNLAFLCFGALMAAVTRPKRALWLVLVVSLPRWAATGLGGLTGAEWPTRTAGALGILVALAAAYAAFALMLEDMRSEEVLPIGRSGPAHHAVEGDLAVQLRNIERQAGVRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ71</accession>
    <name>A0A0F4IZ71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor SigK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_29210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000904">
        <property type="protein sequence ID" value="KJY26783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26783">
        <property type="protein sequence ID" value="KJY26783"/>
        <property type="gene ID" value="VR44_29210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2187"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="22213" checksum="84AA061968ED6CF5" modified="2015-06-24" version="1">MKQPIPFHGSGSAEPAHGDLNDVMRRVAHGDKEAFSVLYDVLAPMIFGIVLRVVRDRAQSEEVAQEVMIDLWRQGARYRPEAGSVTTWAATIAHRRAVDRVRSAQAAADREQAQAAREHTTAFDEVAEQVETRLEAEQVRRCLRGLTELQRQAVTLAYYRGLTYREVAEALRTPLPTIKTRMRDGLIRLRDCMGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZP2</accession>
    <name>A0A0F4IZP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_27380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="JZWV01000829">
        <property type="protein sequence ID" value="KJY27485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950286.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000829.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5357"/>
    <dbReference type="EnsemblBacteria" id="KJY27485">
        <property type="protein sequence ID" value="KJY27485"/>
        <property type="gene ID" value="VR44_27380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1642"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="695" mass="74537" checksum="505614632B436155" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0C1</accession>
    <name>A0A0F4J0C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase subunit(Beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000805">
        <property type="protein sequence ID" value="KJY27712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950210.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000805.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5234"/>
    <dbReference type="EnsemblBacteria" id="KJY27712">
        <property type="protein sequence ID" value="KJY27712"/>
        <property type="gene ID" value="VR44_26970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1556"/>
    <dbReference type="eggNOG" id="ENOG502ZSTD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7318" checksum="218246087EB3E2F0" modified="2015-06-24" version="1">MAPSRPSVRTRPGHGPAGVPTAHAPLARGCRPRGCRAPARRVHGRRVRYVIGSEPGQVNGMRWRGGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J290</accession>
    <name>A0A0F4J290_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818429.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene245"/>
    <dbReference type="EnsemblBacteria" id="KJY28380">
        <property type="protein sequence ID" value="KJY28380"/>
        <property type="gene ID" value="VR44_25480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1193"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="23260" checksum="D3790378BF489583" modified="2015-06-24" version="1">MRFRLTPRETSFYDMFAASADNIVTGSKLLMELLGADPSARAEIAERMRAAEHAGDDATHAIFHQLNSSFITPFDREDIYSLASSLDDIMDFMEEAVDLVVLYNVEELPKGVEQQIEVLARAAELTAEAMPHLRTMDNLTEYWIEVNRLENQADQIHRKLLAQLFNGKYDAIEVLKLKQIVDVLEEAADAFEHVANTVETIAVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3G5</accession>
    <name>A0A0F4J3G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000834">
        <property type="protein sequence ID" value="KJY27436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27436">
        <property type="protein sequence ID" value="KJY27436"/>
        <property type="gene ID" value="VR44_27565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="8682" checksum="4027502DE370F806" modified="2015-06-24" version="1" fragment="single">TGPWLPAPVVAAIAQKAEELLNAEAAEPEEPEEETELLVRDPAPGTVSGAVSGRAVSGPDAVTTTALPPRTPPPTAARPGRSPAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5E4</accession>
    <name>A0A0F4J5E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000758">
        <property type="protein sequence ID" value="KJY28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000758.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28146">
        <property type="protein sequence ID" value="KJY28146"/>
        <property type="gene ID" value="VR44_25990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1301"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="25685" checksum="C0C94B4E8A3CA12E" modified="2015-06-24" version="1">MHATPSPAGRAGPALAAACAVLALWSLAAWSGAVAPGLLPGPVATAAALADSARSGVLLSDLGASLARAGQGFALGSVAGGVLGFATGYLPRLSAAVTPVVSFLRPIPAIALVPLATAWFGIGESAKRLLIAYAVALAVWLYVHDGVSRVPVSHLRAARTLGAPLHRRFTEVLLPAAAPALLAALRYGASVALLALVAAELGGADSGLAYRLQVDGQFLRVDRMFAGLIVLGLLGVAADLVLAAIGRRFVHWSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5K1</accession>
    <name>A0A0F4J5K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29465">
        <property type="protein sequence ID" value="KJY29465"/>
        <property type="gene ID" value="VR44_22885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.511"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="20255" checksum="6F4DF93747492F79" modified="2015-06-24" version="1">MGARGPGRTPLERRCEERLRELALPARRKMTIEEVCEHVGARRGRPLLVLPTALPTGSPHGLWVATDRNDYVFLEERLAPIHQHQVVLHEIGHLVCDHDTSPVLAAEVSRLLLPSLDPGLVRRVLGRGHTDSEAEIEAELVGSLIGRRLSSWTVCRDRPVPPEAHELVARLAVLGPPGHPGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6X3</accession>
    <name>A0A0F4J6X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_22530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949388.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29579">
        <property type="protein sequence ID" value="KJY29579"/>
        <property type="gene ID" value="VR44_22530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.396"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="53"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY29579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="566" mass="60829" checksum="A5B52AC53C09BBE2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7R7</accession>
    <name>A0A0F4J7R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000614">
        <property type="protein sequence ID" value="KJY29808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949292.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000614.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29808">
        <property type="protein sequence ID" value="KJY29808"/>
        <property type="gene ID" value="VR44_21975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.275"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022468">
        <property type="entry name" value="PhnX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03351">
        <property type="entry name" value="PhnX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="24481" checksum="286B9AA9CDB0107B" modified="2015-06-24" version="1">MTDSKSRNLVVLDMAGTTVADGGLVERAFERAAAHLGVDPGTPGHAEKLQYVRDTMGESKISVFRHLFGTEERARLANSAFEQAYAELVDGGLVTPVPGARETIEALRADGHTVVLTTGFARVTQDAILDALGWRDLADLTLCPADAGGRGRPYPDLVLAAFLRTGAVDDVRETAVAGDTAYDMLSGRRAGAGIVAGVLTGAHDRTALTAHGATHVLDSVAGLPALLAAPRTEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7T5</accession>
    <name>A0A0F4J7T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000685">
        <property type="protein sequence ID" value="KJY28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5542"/>
    <dbReference type="EnsemblBacteria" id="KJY28996">
        <property type="protein sequence ID" value="KJY28996"/>
        <property type="gene ID" value="VR44_23995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.777"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="48408" checksum="79DBA830B434596B" modified="2015-06-24" version="1">MFTSVVISAISFALFWVAAFTLWWQMHAWRTPETLASTRFDRPDGGDRLAFSLLLPARHEQAVLEHTIDRLLESSHADYEIIVIVGHDDPETAAVAERAAAGAPERVRVVVDHNETKNKPKALNTALPHCRGDIVGVFDAEDQVHPELLSHVDHAFRATGADVVQGGVQLINFHSSWYSLRNCLEYFFWFRSRLHLHAEKGFIPLGGNTVFVRTEVLREAGGWDQNCLAEDCDLGVRLSSVGKKVVVAYDSDMVTREETPGSLMSLLKQRTRWNQGFLQVYRKKDWQQLPGRGQRWLARYTLMTPFMQAASGVIIPVNFAVAVFLDVPVGIAIITFLPMITAMVTFVFEIVGLHDFGRQYGLRVRFVHYLKLIVGGPFYQVMLAGAAIRAVWREQRGRNEWELTSHTGAHLQTAGAGATHSSAPIREDAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Y9</accession>
    <name>A0A0F4J7Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949222.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000605.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29914">
        <property type="protein sequence ID" value="KJY29914"/>
        <property type="gene ID" value="VR44_21645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.207"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="201"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="401" mass="43435" checksum="179141B1D5DB5BBD" modified="2015-06-24" version="1">MQRLYDFIRRHPTGVDSFWAVLFFGFSMLSVADLGASTALRLATVPVVAAMTAVIALRRKWTQQMFWVATGAGAYQLAIGSPMQTADLAMLVILFTVAASADVPRRVSRAALVTGLLASPLYFLRFGVDKDASSVQEALFVVFVMVPFALAWVMGDSLRTRRAYYAQLVERNQRLEKEREAQAKVAVAAERARIARELHDVVAHNVSVMVVQADGAAYVMDVAPEQAKEALQTISGTGRQALAEMRRLLGVLRTGEPQESEDYVPQPDVEQIEVLVEQVRAAGLTVDFEVEGAPRRLPSGVELTAYRIVQEALTNTRKHGGPEARASVRLVYFDDGLGLLIEDDGRGAAHELYEDGGADGAGHGLIGMRERVGMVGGTLDAGPRPGGGFRISALLPLKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J838</accession>
    <name>A0A0F4J838_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949039.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6948"/>
    <dbReference type="EnsemblBacteria" id="KJY30380">
        <property type="protein sequence ID" value="KJY30380"/>
        <property type="gene ID" value="VR44_20665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8848"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26396" checksum="F0A7B2AB2EAC3D05" modified="2015-06-24" version="1">MGTTQLESVPEPKYWHLKTVLSEALDRDFAVGEILPNERELAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVGSTGHGWPGEAADGWEAVDAVEAVPAGAVLALLGTEAGRPVHTVRRTRVTQGQAVAAELLYVPAASVPGLSAIDAPAGPARARAVLRELQRLALDGQDRSVELGSARADDAKELDRLPGAPVLVVTTRYFTAEGTAAVSVATYRADTCRLTFGDTGMEITETRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8T3</accession>
    <name>A0A0F4J8T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949105.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30209">
        <property type="protein sequence ID" value="KJY30209"/>
        <property type="gene ID" value="VR44_21035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8939"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="37783" checksum="2CED68B8F80BEA3D" modified="2015-06-24" version="1">METTRSEHPRHHSGRPRQTVVVTGASAGVGRATARAFAARGARVALIARGRAGLEAAANEVAQAGGTPLVLPADVSDAAQVAAAADRVEAVFGPVDVWVNAAFATVFAPFEEIRPEEFRRVTEVTYLGYVHGTRAALDRMLPRDSGTIVQVGSVLAERSIPLQSAYCGAKHAVRGFTSSVRTELMHRGSRVKITVVQLPAVNTPQFAWGLSRLPHRPQPVPPIYQPEVAARTIVHAAGHPGRRVYCVGGRAFATVVANRLVPGLLDRYLARTGFSSQQTSEPDRGQRPHNLWNPLDGDGGRDFGTHGTFDDRAHPRSPEAWAARRPRLLWTGAAAATLGLAALRHHRTAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8U7</accession>
    <name>A0A0F4J8U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948827.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30807">
        <property type="protein sequence ID" value="KJY30807"/>
        <property type="gene ID" value="VR44_19480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8505"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470266" evidence="1">
        <location>
            <begin position="22"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="44138" checksum="8B04F5B1BA3F7772" modified="2015-06-24" version="1">MAAATLTAAAPAQATAHPACATPELAAGWYGDNRARLQQLIDQYGRCNPYRPSRDKPVAVFDWDNTVVKNDVGDATMFWLLRNGKIRRPADWKTTSRYLTPAAAQALATACDPLALPGTPLPTGTPEGAACADEVAAVYGTSATRTGATAFAGWDRRTIEPAYAWLTQLLQGWTPGQVRAFAAAARTENLAAPIGTKQQVGTTTATGWVRYYDQQRDLIKNLQAAGFDVWISSASPQPVVEVWARGVGVTADHVIGIRNTTRDGKLTTHLQGCGSVADGADSMITYVDGKRCWINKEVFGVRGAAAEKVQPAARRQVFAAGDSDTDVTFLRDATALRLVLNRNKNELMCRAYDNSDGKWIVNPMFIEPKKQKTTPYPCSTTGYTGHDGTPAPVRRADTSVIPDQTDTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9P6</accession>
    <name>A0A0F4J9P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948995.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6640"/>
    <dbReference type="EnsemblBacteria" id="KJY30458">
        <property type="protein sequence ID" value="KJY30458"/>
        <property type="gene ID" value="VR44_20415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8793"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="511" mass="56889" checksum="0A4438AE979EC592" modified="2015-06-24" version="1">MGEKVVAGGFDLSDRHRYRRKLHECLEGLERLLAEKRFDRPKNMMGLEIELNLAGADGLPRMVNAQVLERIASPDFQTELGMFNLEVNVLPHRLDGRVFDRLAEELSAGLHYAHRQAAEIDAGVVMIGILPTITRADLALANLSAVDRYSLLNEQILMMRGEDFRLDIEGVERLTWSTGSIVPEAACTSVQLHLQVTPARFSDVWNAAQAVTAVQIAVGANSPFLFGRELWRESRPPLFTQATDTRPPELQAQGVRPRTWFGEKWVDSVYELFAENVRFFPSLLPICDEEEPLRVLAEGGVPSLQELVLHNGTVYRWNRPVYGVADGVPHLRVENRVLPAGPTVADVVANAAFYYGLVRTLADEPRPVWTRLSFAEAEANFDAACRYGIDARIRWPRKGRSGGLASVPAVRLVLEELLPMAAAGLDAWGIEPADRDLYLGIIEERCRRRVNGATWQVDTYHRALAGGLDRGAALAATTRRYSELMHRGDPVHTWPVGLEGQEVDAPAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9U9</accession>
    <name>A0A0F4J9U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000514">
        <property type="protein sequence ID" value="KJY31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4129"/>
    <dbReference type="EnsemblBacteria" id="KJY31142">
        <property type="protein sequence ID" value="KJY31142"/>
        <property type="gene ID" value="VR44_18770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8365"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23392" checksum="A80BE6FD7CD46D92" modified="2015-06-24" version="1">MGCGRVGSALAQTLEQQGHTVAVVDQDPTAFRRLGASFGGRRVTGVGFDQDTLREAGIEEAGAFAAVSSGDNSNIIAARVAREMFGVENVAARIYDPKRAEVYQRLGIPTVATVRWTADQMLRRLLPSGAEPLWRDPSGGVQLAEVHTSPAWIGHKVSKLQEETGVRVAFLTRLGEAMLPTSQTVLQEGDLVHVMMRTDEIDKVEAVFAEGPEEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA87</accession>
    <name>A0A0F4JA87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_19875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000548">
        <property type="protein sequence ID" value="KJY30663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30663">
        <property type="protein sequence ID" value="KJY30663"/>
        <property type="gene ID" value="VR44_19875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8594"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470881" evidence="6">
        <location>
            <begin position="39"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="252"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="36638" checksum="983D9D530A915057" modified="2015-06-24" version="1" fragment="single">MSTAPPRRTRLFRRLAAAAAVLALPVAGLVGLAGPAQAAASATATYTKVSDWGTGFEGKWTVKNTGTTTLSSWTVEWDYPAGTQVTSAWDATVTSSGTHWTGKNVGWNGTLAPGATISFGFNGTGPGAPSGCKVNGGSCEGGTTPADNPPSAPGTPTAGGLTETSVTLSWPAATDDKGVKNYDLYRNGAKLATVTGTTYTDSGLTKGTTYTYTVTARDTADQTGPASAPLSVTTPGGGTDPGPGPGPDPGAKVKLGYFTDWGVYQRNYHVKNLVTSGTAAKITHINYAFGNVQNGKCTIGDSYADYDKAYTADQSVDGVADTWDQPLRGNFNQLRKLKAKYPNIKVVYSFGGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBB8</accession>
    <name>A0A0F4JBB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000575">
        <property type="protein sequence ID" value="KJY30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949069.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000575.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30281">
        <property type="protein sequence ID" value="KJY30281"/>
        <property type="gene ID" value="VR44_20840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8898"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12906" checksum="1C7694E174960BEA" modified="2015-06-24" version="1" fragment="single">FEEVYAEGHPQGLRFSAAYDADGRCTGAAGWRIVAGTCDIRKLYVDDLVTAGDRRSTGVGRSLLAYLEDRAREAGCRLLDLDSGTQRTSAHRFYFRERMGVMAFHFGKELDAGPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBF0</accession>
    <name>A0A0F4JBF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948696.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000515.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31129">
        <property type="protein sequence ID" value="KJY31129"/>
        <property type="gene ID" value="VR44_18805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8372"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26945" checksum="799A3050BEAAEF05" modified="2015-06-24" version="1">MFGRRKKNDSADDGGAAEQVDGVRADEAAEAGEPRRVNLPPAPRPDGPWDVTEVPGNPADGRVDLGGILVPGVEGMELRVEVAGDAIVAATVVLRDSAVQLQAFAAPKKEGIWGEVREEIASGITQQGGLIDEVDGPLGWELRAQVPVPLPDGQTGAQLVRFVGVDGPRWFLRGVISGQGAVRPESAGVLEQIFRDTVVVRGDGPMAPRDPIVLKLPNDAQMVPDGVQTAEEQESSRFSGGMGQLERGPEITEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBL6</accession>
    <name>A0A0F4JBL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_20645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949035.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30376">
        <property type="protein sequence ID" value="KJY30376"/>
        <property type="gene ID" value="VR44_20645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8844"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="32327" checksum="EC2FED1C00AB761B" modified="2015-06-24" version="1">MNRIEIRELTKDHGARRVVDHLTFDVLPGKVTGFLGPNGAGKSTTMRMILGLDRPTAGTATIGGSRFTGLDRPLRQVGALLDPQAAHGGRGARDPLLALAVSNGIPASRVDEVLEQTGIAAVARRRTGTFSLGMRQRLGIAAALLGDPAVLLLDEPTNGLDPEGIIWIRELMRSLAAEGRTVFVSSHLMAESASFVDHLVVLGQGRLLADTSLEAFIDARSTPRARLRTSEPERMAAALARAGLRMTAVAEGRWSVDGIRAEQLGSLAAQEGVPLLELSDERASLEEAYLELTADRTPFSATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC13</accession>
    <name>A0A0F4JC13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948390.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000456.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31902">
        <property type="protein sequence ID" value="KJY31902"/>
        <property type="gene ID" value="VR44_17190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7971"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="30620" checksum="1482496F32564586" modified="2015-06-24" version="1">MDEARARDVLTRAGLTGPAELLAFGENAVFALGDLVVKVGREAGLLERAERELAVADWLATAGIPAVRAAEPKPRLVDGHPVTLWHRLPDALRPAGPEDLAALLRPLHALPAPPFALPARDLLGGVERWLRLAGTAVDPEDAAYLRARRDAYAGEVAALTPHLTPGPIHGDALPRNVHVGPDGPVLVDLETVSADLREHDLVVMALSRDRYGLPADGYRAFTAAYGWDVREWEGCALLRGARETASCAWVAQHAPANPKALAEFRRRVASLRDGDPEVRWYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC71</accession>
    <name>A0A0F4JC71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948576.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31414">
        <property type="protein sequence ID" value="KJY31414"/>
        <property type="gene ID" value="VR44_18185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8184"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="43336" checksum="2D8EE0E295E89F6B" modified="2015-06-24" version="1">MSYVEVPGANVPIRMWTDPASVEDSAMRQLQNTAGLPWIKGLAVMPDVHYGKGATVGSVIAMKDAVCPAAVGVDIGCGMSAVKTSLTANDLPGDLSKLRSRIEQAIPVGAGMHREAVDPGRLYGFSAKGFGDLWERFDHVADAVKFRRDRALRQMGTLGAGNHHSEVNIDQNGSVWLTLHSGSRGIGNQLAEHHIGVARGLSHNQGLVDRDLAVFLAATPEMAAYRHDLYWAQEYAKYNRAVMMSLMKEALRKEFRKAKVSFEQEISCHHNYVAEERYDGMDLLVTRKGAIRAGGGEYGIIPGSMATGTYIVKGLGNKAAFNSASHGAGRRMSRAAAKRRFSTRDLEEQTRGVECRKDSGVVDEIPAAYKPIEQVMEQQRDLVEVVAKLRQVVCIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCC0</accession>
    <name>A0A0F4JCC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948350.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7004"/>
    <dbReference type="EnsemblBacteria" id="KJY31982">
        <property type="protein sequence ID" value="KJY31982"/>
        <property type="gene ID" value="VR44_16980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7926"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16707" checksum="A7F3B8EDB7003D8C" modified="2015-06-24" version="1">MSERLQPGDTAPAFTLPDADGNEVSLADHKGRKVIVYFYPAALTPGCTKQACDFTDNLDVLAAAGYDVIGVSPDKPEKLAKFREQEHLKVTLVGDPEKEVLAAYGAFGEKKLYGKTVTGVIRSTVVVDEEGKVEHAFYNVKATGHVAKIIKDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD46</accession>
    <name>A0A0F4JD46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000422">
        <property type="protein sequence ID" value="KJY32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948211.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000422.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32277">
        <property type="protein sequence ID" value="KJY32277"/>
        <property type="gene ID" value="VR44_16235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7670"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="18089" checksum="744BEE6D4AFBEBAE" modified="2015-06-24" version="1">MTTTDDYATYIASLPRVLAGAAALFRDERGRVLLVEPNYREGWALPGGTIESDRGESPRTAARRESAEEIGLDLPLGRLLAVDWSLGPGRPPLAAYLYDGGVLDAAQLASIRLQEEELLSWKLVEPAELPRYLLGSLGLRAQEACRVLESGEGTVELENGRRPQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDJ8</accession>
    <name>A0A0F4JDJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General stress protein CsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_16210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000421">
        <property type="protein sequence ID" value="KJY32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948206.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000421.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32285">
        <property type="protein sequence ID" value="KJY32285"/>
        <property type="gene ID" value="VR44_16210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7608"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7264" checksum="AF627DA468B56DB7" modified="2015-06-24" version="1">MAEKAKGKMEQAKGKAKEAAGKATGNERMQAEGKTDQLKGKAREAAGKAEEQARGIKDSLRRDHREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFL6</accession>
    <name>A0A0F4JFL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947895.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33132">
        <property type="protein sequence ID" value="KJY33132"/>
        <property type="gene ID" value="VR44_14500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7160"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="13736" checksum="826564E6CFC32320" modified="2015-06-24" version="1">MLAETICSAVSAAGLGIAAVTAYRRRFLRAARITGYALVPVGLVLTGAVQWLSGMVFKPAVWIGFGVLGLAWVLLVTTRALERRAVGGSGKTPGAVAPAASAPALGGGATGPSPKPQSAPAEDFSDIEAILKKHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFT1</accession>
    <name>A0A0F4JFT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_15485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948084.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32659">
        <property type="protein sequence ID" value="KJY32659"/>
        <property type="gene ID" value="VR44_15485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="680" mass="72062" checksum="FE199C7C72451D70" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGF8</accession>
    <name>A0A0F4JGF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947971.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32899">
        <property type="protein sequence ID" value="KJY32899"/>
        <property type="gene ID" value="VR44_14970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7410"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046423">
        <property type="term" value="F:allene-oxide cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009695">
        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034871">
        <property type="entry name" value="Allene_oxi_cyc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141493">
        <property type="entry name" value="SSF141493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470915" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17453" checksum="260C60E9CDA97EAF" modified="2015-06-24" version="1">MRPIRAACLGTATLVTLLTCTPVAAAATDAGSARAGDKDRTITLLAEVQQLSRFPVTPGSVSQGDQVVVRSDLFDEAHNKVGETHGTCTTTRGGPDEAEQCVVTYVLPGGQLTVQGMYFNYLDQGPFDNAITGGTGEYKKARGSVHSDTIATTPKVVRRFTIHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK1</accession>
    <name>A0A0F4JGK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000356">
        <property type="protein sequence ID" value="KJY33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33457">
        <property type="protein sequence ID" value="KJY33457"/>
        <property type="gene ID" value="VR44_13935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7073"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="13249" checksum="83A30243688715C3" modified="2015-06-24" version="1" fragment="single">ETAPRADRADADAEPQAEPLAASAEATAQQAQEAPQPVAAAAEPAAPQAEPLTDAAEVEPEPQEAPEPVAAQAGPEPEAEAVADAQPLAAPAEAPTPQAEPQPELATAQADAAPAETGPAAAEAEPQPQADPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGN2</accession>
    <name>A0A0F4JGN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000437">
        <property type="protein sequence ID" value="KJY32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32126">
        <property type="protein sequence ID" value="KJY32126"/>
        <property type="gene ID" value="VR44_16520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7735"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="12634" checksum="16E6E75EB013A251" modified="2015-06-24" version="1" fragment="single">DADSTAALPPPPTPSASAAPSPPPAGTKVASATDPGTGARMTVQVTPAARWVRVRAAVTGVPAGERCRLVVVSRDGTRSTAGGWVVGTAEHGEGKGAALDGSAAVDPADVRAVLVENESGRTFVSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHU6</accession>
    <name>A0A0F4JHU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947799.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7200"/>
    <dbReference type="EnsemblBacteria" id="KJY33389">
        <property type="protein sequence ID" value="KJY33389"/>
        <property type="gene ID" value="VR44_13965"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="444" mass="47212" checksum="13FAD277568E8301" modified="2015-06-24" version="1" fragment="single">MAQWTSAVGTAQLARLITSQQERPPAPGARKAPAYRTLADGIRLLVLEGRVPVAARLPAERELAVALSLSRTTVAAAYEALRTEGFLESRRGAGSWTSVPAGNPLPARGLEPLPPESLGSMIDLGCAALPAPEPWLTKAVQGALEELPPYAHTHGDYPAGLPALRRMLADRYTERGIPTMPEQIMVTTGAMGAIDAICSLFAGRGERIAVESPSYANILQLMRAAGARLVPVAMGAGLSGWDMDVWRQVLRDSAPRLAYVVADFHNPTGALASEEQRRAMVEAARSAGTVLIADETMAELQLDPEPAMPRPVCSFDPAGSTVITVGSASKAFWAGMRIGWVRAAPDVIRSLVAARAYADLGTPVLEQLAVNWLMRTGGWAEAVGMRRAQARENRDALVAAVRRELPDWEFDVPGGGLTLWARAGGLSGSRLAEVGERVGVRVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIA9</accession>
    <name>A0A0F4JIA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000326">
        <property type="protein sequence ID" value="KJY33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947609.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000326.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33925">
        <property type="protein sequence ID" value="KJY33925"/>
        <property type="gene ID" value="VR44_12940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="10799" checksum="B463861134BF6526" modified="2015-06-24" version="1">MFVMELMYTAPIEDVEEELDAHIAWLDGYYASGVFLASGRKVPREGGVILARGVSRAEIEKIAAEDPFSVAGVCEYRITEFIATKTSAGLAEVRESLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIK5</accession>
    <name>A0A0F4JIK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_12810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000319">
        <property type="protein sequence ID" value="KJY34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947583.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene500"/>
    <dbReference type="EnsemblBacteria" id="KJY34015">
        <property type="protein sequence ID" value="KJY34015"/>
        <property type="gene ID" value="VR44_12810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6643"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="42656" checksum="DA2D91EC56BB8B58" modified="2015-06-24" version="1">MPEAVIVSTARSPIGRAGKGSLKDVRPDDLTATIIQAALAKIPELDPRQIDDLMLGCGLPGGEQGHNLARIVAVQMGMDYLPGTTITRYCSSSLQTSRMALHAIKAGEGDVFISAGVETVSRFVNGSSDGLPGTHNPLFADAEARTAAVAQSEGSDWHDPREDGLVPDAYIAMGQTAENLARLKGVTRRDMDEFGVRSQNLAEEAIKNGFWAREITPVTTPDGTVVSKDDGPRAGVTLEGVEGLKPVFRPDGLVTAGNCCPLNDGAAALVIMSDTKARELGLTPLARIVSTGVTALSPEIMGLGPVEASKQALKRAGLTVGDIDLFEINEAFAAQVIPSYRDLEIPLEKLNVNGGAIAVGHPFGMTGARITGTLINSLQFHDKQFGLETMCVGGGQGMAMVIERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKD7</accession>
    <name>A0A0F4JKD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_12295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34238">
        <property type="protein sequence ID" value="KJY34238"/>
        <property type="gene ID" value="VR44_12295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6443"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471015" evidence="2">
        <location>
            <begin position="34"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="28853" checksum="13D494D2A7C2E5F8" modified="2015-06-24" version="1">MTSTPSHRFSRRSVVLAALTLGSAGLLPATARAATGGGAPGGRGGFTVPEITPCAGWGAREPSEDVVVLAARPERIIVHHTATANVTDYSRERAHALARAVQTYHMDMQGWIDTGQHFTVSRGAFVLEGRHNSLSTLGAGDELVRAAHCVGQNSVAIGIETEGTYTSEEPPTAQFAALADLCAHVCRQYGVPASEIYGHRDFNSTACPGDRLYALLPKLRQDVARRLGDDLGVPVPRRPAHLPADWAADPEAVARALTEYLPEGLLGPALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKG1</accession>
    <name>A0A0F4JKG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000298">
        <property type="protein sequence ID" value="KJY34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947456.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34314">
        <property type="protein sequence ID" value="KJY34314"/>
        <property type="gene ID" value="VR44_12120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6511"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471017" evidence="1">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12537" checksum="867682C9C55D9ACC" modified="2015-06-24" version="1">MTRLRTTAMAFAGAAAMFALAAAPAQAAPGDVTTTCANTATPAGYVDVNWGYSASCGGQNLAPNIKQIKQLTGLPIGTVVQACGSTYYPAGWVATSSYFSNSCVAFPNSGFNNNAWTLKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL69</accession>
    <name>A0A0F4JL69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000252">
        <property type="protein sequence ID" value="KJY34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34920">
        <property type="protein sequence ID" value="KJY34920"/>
        <property type="gene ID" value="VR44_11160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease_alpha" evidence="3">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="20483" checksum="2652C6C40F56AE36" modified="2015-06-24" version="1" fragment="single">MSRPSRHSDHCAPGSRHIDPYEYATVHGPRAGDRVRLGDSGLVVRVESDAQKPGDEFLAGFGKTARDGLHLKAAAVRGTCDVVISNVLVIDAVLGIRKVSIGIREGRIHAIGRAGNPDTLEGVDVVVGTGTTMISGEGLIATAGAVDTHVHLLSPRIMEASLASGVTTVIGQEIGPAWGVGVNSPWALKHGFNAFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMK2</accession>
    <name>A0A0F4JMK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_09815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000212">
        <property type="protein sequence ID" value="KJY35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947031.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3694"/>
    <dbReference type="EnsemblBacteria" id="KJY35592">
        <property type="protein sequence ID" value="KJY35592"/>
        <property type="gene ID" value="VR44_09815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5463"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="31069" checksum="B198EAF2E4563F03" modified="2015-06-24" version="1">MGPQAGGGTVMSTPLVKLTGVSKYYGNIRALRDVSLEVSAGEITCVLGDNGAGKSTLIKIIAGLHRHDAGTFEIEGEETVLANPRAALDRGIATVYQDLAVVPLMPVWRNFFLGSEPTRGRGPFRRLDVAHMRETTRAELLRMGIDLRDVDQPIGTLSGGERQCVAIARAVHFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDAGLGVVLITHNPHHAHLVGDRFVLLKRGAMAGSHTRDSITLDELTRQMAGGSELDELSHELERVAESGPDTPSGSTPATASDRDDTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNI9</accession>
    <name>A0A0F4JNI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000231">
        <property type="protein sequence ID" value="KJY35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35328">
        <property type="protein sequence ID" value="KJY35328"/>
        <property type="gene ID" value="VR44_10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470893" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="5782" checksum="A8DB682F2287EAE9" modified="2015-06-24" version="1" fragment="single">MYTALLRATTVLGAAAVLALGGAAAASADGVGSSGIGNPGVGSAGIGNEGVGNAGIGNEGVGNAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPE1</accession>
    <name>A0A0F4JPE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000183">
        <property type="protein sequence ID" value="KJY36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946840.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000183.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36045">
        <property type="protein sequence ID" value="KJY36045"/>
        <property type="gene ID" value="VR44_08800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5005"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="24012" checksum="14052BBB680D93AE" modified="2015-06-24" version="1" fragment="single">MEEPRTTSPLRRPDGEPVRILVVDDEPDVTDVLASALTAEGCEVRTAADGAAAVTAGLEFRPDAVVLDRMLPDLDGVEVLRALRRDAPRVGVLFLTARDAVEDRIAGITAGGDDYVTKPYSLEEVLARLRGLLRRAGMLADSDGAHRLTVGDLGMDEEAREVTRGGVVIGLSRTEFELLRFLMRNPRRVLSKAQILDRVWAYDFGGQAHVGELYISYXR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPN7</accession>
    <name>A0A0F4JPN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_09395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946954.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5575"/>
    <dbReference type="EnsemblBacteria" id="KJY35713">
        <property type="protein sequence ID" value="KJY35713"/>
        <property type="gene ID" value="VR44_09395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5207"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="527" mass="54442" checksum="6318F689B794AFE6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR52</accession>
    <name>A0A0F4JR52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000146">
        <property type="protein sequence ID" value="KJY36660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946592.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000146.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2259"/>
    <dbReference type="EnsemblBacteria" id="KJY36660">
        <property type="protein sequence ID" value="KJY36660"/>
        <property type="gene ID" value="VR44_07490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3973"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="23633" checksum="47D1A1D9C23E4EA2" modified="2015-06-24" version="1">MVLADGDVTLRPIKLRDQRDWREVNRRNRDWLRPWEATIPPPAPWGPVIHRPTYRQMVRHLRAEANAGRMLPFVIEYQGRLVGQLTVAGITWGSMCAAHVGYWVDRDVAGRGVMPTAVALAVDHCFLRVGLHRIEVCIRPENGPSRRVVEKLGFREEGLRPRYLHIDGAWRDHLVFALTAEEVPEGLLRRWNRVRKKESPPPAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRB6</accession>
    <name>A0A0F4JRB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000164">
        <property type="protein sequence ID" value="KJY36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946721.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000164.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36394">
        <property type="protein sequence ID" value="KJY36394"/>
        <property type="gene ID" value="VR44_08145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4378"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="32332" checksum="7140DD10A08F6AA9" modified="2015-06-24" version="1">MAATLLVASFVVFGALYLAPGNPASFLLAGRSASPEALAAINAQYHLDDPFLVRYLRWLGDVLHGDFGRSITYRTDVSRLLADRLPTTLVLIAMSLVVVVAVGLLLGRIAAVRGGATDSAILVTTTFAVGTPSFVAAVLLQGVFAVDLGWFPSSGTGEGGFGDLVRHLVLPSVALALYLIGMLARVTRSAMLEALDSEHVTVARSRGVPERQVVRRHVFRNSLGTVLTTGGLIVSTLLVCTILVETAFSVGGIGQLLELSTTTKDFPTVQAISLIIVALFMTVNLLVDLALPLVDPRVTLGSRRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRM6</accession>
    <name>A0A0F4JRM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946516.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000134.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4628"/>
    <dbReference type="EnsemblBacteria" id="KJY36850">
        <property type="protein sequence ID" value="KJY36850"/>
        <property type="gene ID" value="VR44_07060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3758"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="491" mass="54941" checksum="0F5D3F992E3DD5CC" modified="2015-06-24" version="1">MGADQIRRWESGALAHAVNDPFGQGPLPWFRGSEVYFDDTGQVVPWYVDPALAPGRTSQARGGGPRTADDVHRQIKGFTSTGAVAPGEAIDFHITVDPPQQFQVDVYRIGHYGGDGASKITTSPRLSGIVQPPPLTADRTVSCHHWWQSWRLQVPSYWSVGAYVAVLTTADGYRSHIPFTVRDDHPADLLLLLPDITWQAYNLYPEDGRTGASLYHAWDEEGRLLGERDAAVTVSFDRPYAGAGLPLHVGHAYDFIRWAERYGYDLAYADTRDLHAGRVDPTRYRGLVFPGHDEYWSLPMRRTVERARDHGTSLVFLSANTMYWQVELAPSPSGVPDRLLTCRKRRGPGRPSLWREVDRPEQQLLGIQYAGRVPEPAPLIVRNATHWLWDSTGAAENDELDGLVAGEADRYFPRTQLPEHQDRILLAHSPYLDGEGAKRHQETSLYRAPSGALVFASGTFAWSPALDRPGHVDERIQRATANLLDRICKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS30</accession>
    <name>A0A0F4JS30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946608.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36644">
        <property type="protein sequence ID" value="KJY36644"/>
        <property type="gene ID" value="VR44_07510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3978"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18344" checksum="F6AEEA093C3FE800" modified="2015-06-24" version="1">MHLRAVPYDHPDALKLDAQVQLEYQERYDGEGDATFLDPAMFLPPAGLYLLAYDASDTPVASGAWRAQDHNDEGYSDGDAEVKRMYVIPEARGKGLARRILAELEADAAAAGRRRMVLETGDRQPEAIALYLSSGYELSEKFGYYRDYESSRCMAKPLPSPHTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS45</accession>
    <name>A0A0F4JS45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">VR44_07660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946624.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36578">
        <property type="protein sequence ID" value="KJY36578"/>
        <property type="gene ID" value="VR44_07660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4144"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="24119" checksum="A10AFA828A884E7D" modified="2015-06-24" version="1">MFSYRRTPELPTREEALKGRAEAQFTLPERHTVLGNPLAGPYPEGLEVADFGLGCFWGAERKFWQTPGVWTTLAGYQGGYTENPSYEEVCSGLTGHTEVVRVVFDPAQVSYSALLKLFWESHDPTQGFRQGNDVGTQYRSAVYTHSPAHQAAAEASRDAYQKVLTASGYGTITTAVLPADPRPFWPAEPYHQQYLDKNPGGYCGIGGTGVSCPIGVAPAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS50</accession>
    <name>A0A0F4JS50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946629.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5530"/>
    <dbReference type="EnsemblBacteria" id="KJY36583">
        <property type="protein sequence ID" value="KJY36583"/>
        <property type="gene ID" value="VR44_07685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4149"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="18319" checksum="632F01A88AEF105E" modified="2015-06-24" version="1">MPSIPASSDLPTAAEAPAGSGLLDALQHQVAVFARRAEQTRLGGVGQARNSMDRAAYLLLNRLDLEGPMGVKALAAGMGIDSSTVTRQVAPLVDAGLVKRTSHPEDGRAVVLALSPRGLARLEEVRSSRRELMARVTEGWAEEEREEFTRLLTRFNGSLSELMSAAAEGGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSE0</accession>
    <name>A0A0F4JSE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-CGNR multi-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946342.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37287">
        <property type="protein sequence ID" value="KJY37287"/>
        <property type="gene ID" value="VR44_06150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2566"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22930" checksum="C34848D67D0E3324" modified="2015-06-24" version="1">MELAHYSDYAVRLVNTEEPARNKDALTSADDVRALFGPSTQMARRVTDTDVTRFRNVRGRLRAVFEAADGGDHVLAVDLLNSLLMEFPVSPQVSGHDLVGPDGRPDWHIHLADHPSNASAGYAAIASFGLAFHLTEHGPDRLGLCQAPPCRNAYLDTSTNRSRRYCSDRCATRANVAAYRARKRLEAEESARSGRTADSAHDSRALSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSI6</accession>
    <name>A0A0F4JSI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_05880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000109">
        <property type="protein sequence ID" value="KJY37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946295.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000109.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3762"/>
    <dbReference type="EnsemblBacteria" id="KJY37332">
        <property type="protein sequence ID" value="KJY37332"/>
        <property type="gene ID" value="VR44_05880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2218"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="487" mass="50097" checksum="62A3755B5FD25516" modified="2015-06-24" version="1">MTQSSVEPKTTAEEAGEGSPKPAGSSWLDRYFHITHRGSSVGTEIRGGVTTFMAMAYILLLNPLILSGKDVAGDTMSQKALITATAFAAAATTLLMGFIGKVPLVLAAGLSVSGVLSSQVAPQMTWPQAMGMCVMYGVVICLLVVTGLREMIMNAIPLALKHAITMGIGMFVALIGLVKAGFVGKGPEFGPPVQLGSVGELAGWPVLIFCITLLAIFMLQARKVPGAILIGIVGGTVIAAIVNAVVDIDPKAWKNGPPVLDGSAISMPDFSLFGKVEFGGWGDVGVMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLADDQGRMPGLSKALFIDGAGGAIGGIAGGSGQTVFVESATGVGEGARTGLASVVSGLLFAACLFFTPITQIVPGEVASAALVVIGAMMMQNARHVDWADAATAIPVFLTVVIMPFTYSITPGVAAGVLSYVAIKIAQGKAREIGAFMWALTVVFVIFFALHPIEAWLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTM7</accession>
    <name>A0A0F4JTM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946420.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37098">
        <property type="protein sequence ID" value="KJY37098"/>
        <property type="gene ID" value="VR44_06540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="19302" checksum="695956DE30F50122" modified="2015-06-24" version="1">MNELETIDAELLPVAQGDLQGEARNPGLTVHTAADYELSQETLEALKAAIPPETYRKYDFWLRRAAGWCAGRRSVVPMTTETLTEWIRVTIDTPSEKTGEPYGASALGQAVAAILAAHTWSRIPVEQHPDPRPARLLIKAHKKRQGDPDGPSGPPDRHLVHLGHDPPLRVLGSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTW9</accession>
    <name>A0A0F4JTW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946109.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000090.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37812">
        <property type="protein sequence ID" value="KJY37812"/>
        <property type="gene ID" value="VR44_04875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1060"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28663" checksum="0FFCCE49D8ECAD50" modified="2015-06-24" version="1">MNTELLMSDATHFRIDYVINPYMDTSVQPDARAAVSEHDAIAAAHLAAGRTVHRMASAPECPDMVYTANGAWVCGDRAVLGDPPAARAAEIPYFRSWLKENGIDVFDAPYSFSGQGDTLACGDLLLAGYGQRTDRRMHDVLADLTGHQVVALRTAGEEWYDLDLAVAVIDEGTLAYYPGALEAESVGVLRSLGLELIEVGTEEARAFALNLISDGRTVTMTTGAPRLAATLRERGATVVELDTAQLRKGGGGVRCTALTLDNPVPAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUC7</accession>
    <name>A0A0F4JUC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946622.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36576">
        <property type="protein sequence ID" value="KJY36576"/>
        <property type="gene ID" value="VR44_07650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4142"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9860" checksum="224183CD3121502A" modified="2015-06-24" version="1">MSSGWRWEYDPDHAHVAGGVPAKVVAEVERLARQLVDLADMGIHLDEVGNGPQPGGLRRMDAAGGWFYFLAAPRARLIIVVRIVPPFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUE3</accession>
    <name>A0A0F4JUE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000105">
        <property type="protein sequence ID" value="KJY37429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946260.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37429">
        <property type="protein sequence ID" value="KJY37429"/>
        <property type="gene ID" value="VR44_05700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1955"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9984" checksum="E4FF9B27B963EE54" modified="2015-06-24" version="1">MKIEVVRTGGFAGIERRAEVDTSGRPDEREWQALAQLALHPHPRAAEGPGRVRDGFAYRITVDGRTVSCHDPHLTDAQRNLITRVLKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUN7</accession>
    <name>A0A0F4JUN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946015.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38072">
        <property type="protein sequence ID" value="KJY38072"/>
        <property type="gene ID" value="VR44_04360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.440"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="38779" checksum="0B18B8226530A8EB" modified="2015-06-24" version="1">MTETLALVESPAQLLNVLEWAHAHPGEAASLTIAVLQPVDPRSRAQVRRLCRYASQAKVVWRRYEVRAGYLGRAGELVRLGRAVAAARRLVIGDLFSRTIQLLLPRSRAREVVVVDDGTATTELVALLTSGQQLTRWHQGDAKTAKGGPVNRWLAREELERAVFFTCMPVAAPPGAEVRANEYAWSRTTFGPARPRPGTDLAGSSLVETGVIDEDRYIEAVGWISRTRAAGRYLAHRRESAAKLDRIAELTGMEIVHPELPLELTALTEPIGLSLLTFASTIAYTLPIVLRGAPVRVELCEIDDAWITPDTAARSVDFLRRISSLAVARHGLASIPPQGRRRTGERSEALPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUY7</accession>
    <name>A0A0F4JUY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_TE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946063.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37965">
        <property type="protein sequence ID" value="KJY37965"/>
        <property type="gene ID" value="VR44_04650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1011"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="27006" checksum="D267742B4A18DCB5" modified="2015-06-24" version="1">MNSTWFRRYTADAGHGPRLVCFPHAGGSATAYKPLAHALDGELDVVSVQYPGRQDRFEETPFTDLEPLVEAVAGELARGLAADPGRPYALFGHSMGALVAFETARRLEGAGLPGPQRLFVSGRGAPDTRSGAHYLRFEDADVLAEVRGLSGTDQGLLDNPEVLEMVLPALRADYRAVGTYVWRGGGPLASPVTALVGDRDPMVTVGEAWAWREHTTGGCALEVFPGGHFYLQDQLGPVASAVTEGLLARAFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV76</accession>
    <name>A0A0F4JV76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="9" type="ORF">VR44_05035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946139.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene167"/>
    <dbReference type="EnsemblBacteria" id="KJY37749">
        <property type="protein sequence ID" value="KJY37749"/>
        <property type="gene ID" value="VR44_05035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1322"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="39"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="8">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36062" checksum="87F4FF01A312ED61" modified="2015-06-24" version="1">MGPHPAVAAIRLAVRRVLHDVLTDLTDPADRAAATPPLVLVACSGGADSMALASALAFEAPKLGIRAGGITIDHGLQPGSDLRAAEVVNRMTALRLDPVESVAVRVGRDGGPEAAARDARYAALDEAADRLGAAAVLLGHTRDDQAETVLLGLARGSGIRSLSGMAEVSGGPGRTRRYRRPFLHIDRQTARKACMVQSLPVWDDPHNIDPAYTRSRLRHEGLPALEKALGKGVVEALARTAQLSRDDADALDAWAADAEAGVRDADGRLECAKLYALPPAVRRRVLRRAVVAAGSPAGSLFARHIEEVDRLITGWRGQGAINLPGRVEAQRQGGRLVIRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVD0</accession>
    <name>A0A0F4JVD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_03810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000070">
        <property type="protein sequence ID" value="KJY38322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945918.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38322">
        <property type="protein sequence ID" value="KJY38322"/>
        <property type="gene ID" value="VR44_03810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8665"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20460" checksum="578247313621E0C7" modified="2015-06-24" version="1">MTRVIAGTAGGRRLAVPPGTGTRPTSDRMREGLFSTWESLHGVEDSRVLDLYGGSGAVGLEALSRGAAHTLLVEADAKAAKAIRDNIRTLGLPGAEFRAGKAEQVVAAPAPGDPYDIVFLDPPYAVEHGDLGEILLTLRANGWLTDDALVTVERSTRSGPFPWPKGFEPLRSRKYGEGTLWYGRAASTSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW85</accession>
    <name>A0A0F4JW85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_04550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene677"/>
    <dbReference type="EnsemblBacteria" id="KJY37993">
        <property type="protein sequence ID" value="KJY37993"/>
        <property type="gene ID" value="VR44_04550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.719"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="181"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY37993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="33654" checksum="5B1B362F58A339BF" modified="2015-06-24" version="1">MEDIPQDWGRSVVTIGSYDGVHRGHQLIIGRAVAKARALGVPSVVVTFSPHPSEVVRPGSHPPILAPYDRRAELMAGLGVDALLILPFTAEFSQLSPADFIVKVLVDKLHARAVIEGPNFRFGHRAAGNVDFLRELGSTYDYEVEVVDLVERGEAGGGVPFSSTLARKLVAEGDMEGAAEILGRPHRVEGVVVRGAQRGRELGYPTANVETAPHTAIPADGVYAGWLSADGERMPAAISVGTNVQFDATERTVEAYAIDRLGLDLYGKQVSVEFLAYVRGMAKFESLDGLLEAIADDVKRARALTDAFDAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWF1</accession>
    <name>A0A0F4JWF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946312.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2623"/>
    <dbReference type="EnsemblBacteria" id="KJY37316">
        <property type="protein sequence ID" value="KJY37316"/>
        <property type="gene ID" value="VR44_05970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2408"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="24051" checksum="67DCB7FC2EFDAE5F" modified="2015-06-24" version="1">MTDTQVREKTPVDFWFDPLCPWAWMTSRWMLEVEKVRDVEVRWHVMSLAVLNENKLDELPERYRELLGPKGWAPVRVVIAAQQKFGEEVTGKLYTALGTKIHNEDRGATREVIADALAEVGLPAELLAYADSDEYDEVLRDSHNDGIERVGQEVGTPVISVPGADGEEVAFFGPVVTPAPRGEAAARLWDGTLLVASTPGFYEIKRTRTQGPIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWP3</accession>
    <name>A0A0F4JWP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_05735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000106">
        <property type="protein sequence ID" value="KJY37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946267.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000106.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37406">
        <property type="protein sequence ID" value="KJY37406"/>
        <property type="gene ID" value="VR44_05735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1962"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="416" mass="43957" checksum="A0A63D0E5C8CFC9F" modified="2015-06-24" version="1">MTQTAPTSSTQDAAPTAPREPGRIHRAWFAAAVAFVTIIGAAAFASLPGLLIGPLHEEFDWSRGTIGFAVSVNLALYGLTAPFAAALMDRFGIRKVVALALTVIACGSLATVWMTASWQLVLFWGVLVGLGSGSMALAFAATVTNRWFTARRGLVTGILTAAGASGQLIFLPLLSWLVEHHGWRPASVTVALAALSVVPFVWLLLRDHPADVGLAPYGGTYEPKPAPVQGAARRAVTVLFHAARTGPFWLLAGTFAICGASTNGLVRTHFTPVLGTIASGWFTDRFEARRLLAVYYALRGVSLLFLPVLLAPAVHPPMVLFIVFYGLDWVATVPPTIALCREHYGQVSAIVFGWVLASHQVGAALVAFLGGVARDAFGSYDLVWYASGGLCAVAALMAMVIRRRPERAAAAVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXU1</accession>
    <name>A0A0F4JXU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000041">
        <property type="protein sequence ID" value="KJY38945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945702.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38945">
        <property type="protein sequence ID" value="KJY38945"/>
        <property type="gene ID" value="VR44_02610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6828"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="32674" checksum="67AE5D1392B41B31" modified="2015-06-24" version="1">MAGRPHGPALDLDALTAIDVHTHAEVSKDGHGALSPELFGASEAYFKAHGHRQPTIDEMAAHYRERRMAAVVFTVDAEHATGHPRISNEEIAESCAAHADALIPFASIDPHKGRAGVREARRLVEEHGVRGFKFHPSIQAFSPDDRLAYPLYEAIEELGVPALFHTGQTGIGAGVPGGGGIRLKYSNPMAVDDVAVDFPELRIVLAHPSFPWQDEALAVATHKPHVYIDLSGWSPKYFPPQLVRYANTLLKDKVLFGSDYPVITPDRWLADFAALDIKPEVRPKILKENAARLLGLSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYA7</accession>
    <name>A0A0F4JYA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000084">
        <property type="protein sequence ID" value="KJY37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946054.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37956">
        <property type="protein sequence ID" value="KJY37956"/>
        <property type="gene ID" value="VR44_04605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1002"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01026">
        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20840" checksum="D1821CC9F735C83D" modified="2015-06-24" version="1">MDEMGEFREAVARSAAGGGAFGEAAPGVRGAVLVEGPSDHAALEALARRLGRDLEAEGICVLSMGGATNVARYAELLGPPGLGLRLTGLCDEQERPFYDRALEEVFVCVKDLEEELIRALGVARVEEIVEAEGELGPWRTFTRQPAQRGRSPEQRMRRFLGTQSGRKIRYGRLLAGALDPASVPGPLDALIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYF5</accession>
    <name>A0A0F4JYF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000028">
        <property type="protein sequence ID" value="KJY39160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945596.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39160">
        <property type="protein sequence ID" value="KJY39160"/>
        <property type="gene ID" value="VR44_02070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5822"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="96"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="34199" checksum="7CCD7CB73AB257F2" modified="2015-06-24" version="1">MGNHVALATDMTSLPIDYDMPLLLEACKEAGVRAEICSWEDPDIDWGAFDAVLLRSPWSYVEQLPRFLRWCERVTSVTHLLNPLPVVRWNLDKSYLGDLDAAGVPVVPSSFVAPEAEPADALRAFLERYPDAAEFVVKPTVGAYSRDVQRFSRAQEPDATRHIAKLLEQGCDALIQPYMDAIDRDGETDLIYFDGEYSHAIRKRALLLPDGTVDVPTQDARTARDAAPDERAVASAALKAVVARLDLERPLLYGRVDLIRDGEGRPVLLELEVCEPSLSMPFAEGSAHRFARAIAARLEDISRTRKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYL7</accession>
    <name>A0A0F4JYL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ORF">VR44_02730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000046">
        <property type="protein sequence ID" value="KJY38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945725.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38848">
        <property type="protein sequence ID" value="KJY38848"/>
        <property type="gene ID" value="VR44_02730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6787"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18850" checksum="B46D7791BA00C345" modified="2015-06-24" version="1">MNDKAREPGRPAEEPDVPRDAAPALPELDAEELRDRWQRAVADVENLRKRCERQLEEARRSERDRVTAEWLPVVDHLELALQHAAADPRSIVAGVEAVCQQAFAVLAQLGYRRIAQVGDRFDPALHEAAQVREEPEAAPGSIVQVLRPGYDSDSGLLRPAVVSVAAKPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K075</accession>
    <name>A0A0F4K075_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_01505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945494.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39504">
        <property type="protein sequence ID" value="KJY39504"/>
        <property type="gene ID" value="VR44_01505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4734"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471393" description="Microbial collagenase" evidence="13">
        <location>
            <begin position="32"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M9_N" evidence="14">
        <location>
            <begin position="151"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY39504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="795" mass="85884" checksum="5A24127265F0D0FD" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0M8</accession>
    <name>A0A0F4K0M8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ORF">VR44_00855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018547628.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4773"/>
    <dbReference type="EnsemblBacteria" id="KJY39669">
        <property type="protein sequence ID" value="KJY39669"/>
        <property type="gene ID" value="VR44_00855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2878"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="45" mass="5224" checksum="784B9E2084629CEF" modified="2015-06-24" version="1">MSKRTFQPNNRRRAKTHGFRLRMRTRAGRAILANRRSKGRAALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Y2</accession>
    <name>A0A0F4K0Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000008">
        <property type="protein sequence ID" value="KJY39774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1074"/>
    <dbReference type="EnsemblBacteria" id="KJY39774">
        <property type="protein sequence ID" value="KJY39774"/>
        <property type="gene ID" value="VR44_00535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.107"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="101"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Thump_like" evidence="2">
        <location>
            <begin position="317"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="41258" checksum="C174197A4BD51CDB" modified="2015-06-24" version="1">MTPEDFAALLTPEGRALLDSLRDYDPAQELAVATRLRREHPAALVSAALGQARLRQRAVAKFGAEDAFRMFFTPGGGEMATRASVASYRAERLAGLGVRSVADLCCGIGGDALALARRGIRVLAVDLDPLTVAVARANAEALGLADLIEVREADVTTVDVSSYDAVFIDPARRGGRGRIFDPEAYSPPLSWAVEAARTAKYAAIKIAPGIPHEAVPAEAEAEWISDHGDVKEAVLWFGTAPGTVRATLLPGPVGLGTAEPLPDPEAGPVGRWLYEPDGAVIRAHLVAEVAAQLGGRLIDPTIAYVTADELRDTPYATAYEITDVLPFGLKKLKALLREREVGVLTVKKRGSAIEPEELRRKVKPAGPNSATVFLTRVAGAPAMLIGSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Y8</accession>
    <name>A0A0F4K0Y8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_01215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39593">
        <property type="protein sequence ID" value="KJY39593"/>
        <property type="gene ID" value="VR44_01215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2959"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="428" mass="44388" checksum="26AC441428731A25" modified="2015-06-24" version="1">MTESSTASNPDIEISRRRLLGTVGAAGAVGLALGATGGALVHSAVTDSPAGAPGAAGALSSLGSTAVAFEGDHQAGITTPLQAKGHVLAFDLAPGAGRTEAAALMRRWSETARRLMAGETAPTGDSGIALDAGPSSLTVTFGFGHSFFERTGLTARRPAALDPLPDFSSDRLDAQRSNGDLWVQIGSNDGLVAFHALRAIQKDAGEAARVRWQMNGFNRSPGATASPMTARNLMGQIDGTGNPKPADPDFDKRIFVPAAGPGPAEHAWMAGGSYAVVRRIRMLLDDWDKQSLAQQEQVIGRTKANGAPLTGGGETTPLALDKLGTDGKPVIPSNAHARISAPAQNGGAAMLRRPFSFHDGIAPDGTPDAGLLFICWQADPLRGFVPVQRKLDRGDALSAFIRHESSGLYAVPPGPRTGEYVGQRLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6Z1</accession>
    <name>A0A0F4I6Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001682">
        <property type="protein sequence ID" value="KJY17228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17228">
        <property type="protein sequence ID" value="KJY17228"/>
        <property type="gene ID" value="VR44_40075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6355"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8596" checksum="18B0413521B11727" modified="2015-06-24" version="1" fragment="single">PASFLPVRAAVRRRDPRFLTATPDLAAALSVAVDDGRDLLEHVPDQWKEIKTWAKRFLPPVKPSPASPNNSAIPSPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7X7</accession>
    <name>A0A0F4I7X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_40275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001712">
        <property type="protein sequence ID" value="KJY16831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952662.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001712.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16831">
        <property type="protein sequence ID" value="KJY16831"/>
        <property type="gene ID" value="VR44_40275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY16831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="30051" checksum="BCA3E841B7E80772" modified="2015-06-24" version="1" fragment="single">EMCIRDRYPLAPWMPPGALQAFLTDVGFPDLTPLAPLTAGHAGAPVLRTPRPLPTVLFSHGARSHQSDHTITVQNLASHGYAVITIAHQYDTYTEYPDGRIAVPIRDRPAPTLPGDFAADLRFVLDCVEQLAAGHNPDAGRRQLPAGLLGSLDPRRIGAFGWSKGGTATARAMLADERIRAGLALDAPMQMNPPLSGDLDRPFMMMTAAFTRATIPEAAAFWSHLRGWRLNIQAQGAVHISYGDNEALFPQVARLRGWTAQQLESVIGTLNPNEAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IH46</accession>
    <name>A0A0F4IH46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001459">
        <property type="protein sequence ID" value="KJY21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21375">
        <property type="protein sequence ID" value="KJY21375"/>
        <property type="gene ID" value="VR44_38300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="13910" checksum="EA4267BF544628CB" modified="2015-06-24" version="1" fragment="single">LLLETAWEAVERAGLDAAPLRGSATGVFIGTNGQDYGTLAAASDDDLGGYVGTGSAASVVSGRISYVLGLEGPAVTVDTACSASLVALHLAGEALRRGECTLALAGGVTVMSTPSTFVEFSRQRGLAPDGRCKSFADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4II10</accession>
    <name>A0A0F4II10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001468">
        <property type="protein sequence ID" value="KJY21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952313.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001468.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21093">
        <property type="protein sequence ID" value="KJY21093"/>
        <property type="gene ID" value="VR44_38385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5326"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="19063" checksum="6E08D2C2C8F4BB83" modified="2015-06-24" version="1">MNSRTSMAEWLAASHPDPRRVWAEWTEHGIAVIPVGQTFGAVRIPDAVVHAAVESTHPDDIAFALSERLDGPVIHDGRGRNFYPLLRPEDRLDWHTTAPGVEQLTPHTHLGVPAMNRCEYTRETPIYWSVPGTEPSHCHSASVALLIRVGTARLAEVTDQPKTVVGRRDLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKT9</accession>
    <name>A0A0F4IKT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001426">
        <property type="protein sequence ID" value="KJY22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22304">
        <property type="protein sequence ID" value="KJY22304"/>
        <property type="gene ID" value="VR44_37965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5157"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8377" checksum="7619DBB600F4857C" modified="2015-06-24" version="1" fragment="single">MLNDDLTIRRASTSDGPALMALERAGWSWLSDVMPQRAEDALMFDERYGVEPFLVAELAGRVVGYIRQIPPTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IL68</accession>
    <name>A0A0F4IL68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001428">
        <property type="protein sequence ID" value="KJY22223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952241.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001428.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22223">
        <property type="protein sequence ID" value="KJY22223"/>
        <property type="gene ID" value="VR44_38000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5166"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046095">
        <property type="entry name" value="DUF6113"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19608">
        <property type="entry name" value="DUF6113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="12425" checksum="90C6DB0E48401D14" modified="2015-06-24" version="1">MTTALTAGRIAALLGLLVAGTATGLAGWLVVDLWFPAGLLLAVLALLGLFLGARIALGGGLGVGVAAAGWFLSYVLLGVPRPEGDFLLGSSGMGMYAYLLGGSAVAVICATMRGPVEPPVSASKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQM0</accession>
    <name>A0A0F4IQM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosylhomocysteine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001360">
        <property type="protein sequence ID" value="KJY23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952101.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23793">
        <property type="protein sequence ID" value="KJY23793"/>
        <property type="gene ID" value="VR44_37240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4839"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="71"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="474" mass="49105" checksum="DCB530E12F0F5168" modified="2015-06-24" version="1">MRHEPAATLPDPRRLSGGPRLLRPAVVMTPEGPVEGYAAVVDGGTFRAVGPAALLEREHPGLTPVLLPGHVLMPGFVDAHHHLTQSFGAALAFGEPSEIFRRVWVPLEGALDEEAAYTAAKLAALESLRGGFTTVTEAGTRAPVDAGVVAAAAGDAGIRCVLGLVCNDVPEAAVPGGTDGAAVLAAAERHLARYEGAELVHPSLAVSVPEAATARTLRDTARLAAEAGAVVQIHVNEHLAAVERSLVRHGLRPLEYLREVGALGPQLLAAHATLVTPAELTLLADTGAAVSYNPVASAWKGNAVAPATTMAERGIRFGLGTDGTRGDAFRLVEAAEFAQRLAYGLATGDSSCGAGWSWLERGGPGGADAVGLGALTGRIAAGAAADFLLVDVSGPEMRTSRDLPWELVRRGNRDQITAVFVAGRLRMWRGRAVGWDDRALLQRAAELADEVVARAAVTRAHPTSTAARAGSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQS3</accession>
    <name>A0A0F4IQS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="9">Holo-ACP synthase</shortName>
            <ecNumber evidence="9">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acpS</name>
        <name evidence="13" type="ORF">VR44_35640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01001243">
        <property type="protein sequence ID" value="KJY24352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951796.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24352">
        <property type="protein sequence ID" value="KJY24352"/>
        <property type="gene ID" value="VR44_35640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4247"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY24352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27268" checksum="7ABB32FCE85480CE" modified="2015-06-24" version="1">MQTRPVAPPAGGLGWANLGMDIVSVGRVRRLLAAYGEDFFQRMLTPGELADCHTSARLDVLSLCGRIAAKEAAFKTLRVGAVVLPWRDIVVRRSEGGWPLVELRGAAAGMAADSGIAGVTVTISHDVDYAVAVAAPLLDPGPPEPPAPPALPDPAAGSAHTPQPVHSTSRRDTMSEGLQLVKNWLLARHEELDDIASDLDLIENRLIDSLSFVEFVFLLEQHSGRAIQMETLEVDEIRTLDAIATHFFSAEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR68</accession>
    <name>A0A0F4IR68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001276">
        <property type="protein sequence ID" value="KJY24169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951893.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001276.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24169">
        <property type="protein sequence ID" value="KJY24169"/>
        <property type="gene ID" value="VR44_36145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4471"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="25931" checksum="52DBBBBC4686A9B9" modified="2015-06-24" version="1">MTTRARSFDAAAALYHASRPGYPDALFDAVEELAGASLRGARVADAGAGTGIASALLHARGARVLAVEPGDGMAAELRRAHPGIPVVRGDGDRLPLASDSLDFLTYAQAWHWTDPARSVPEARRVLRPGGALALWWNDLDLSVDWIAEQDERIAGLFGAPAGPQPREDPEELGLATREVRWSRRIPVDAHLANLSSHSAFLLLGESATREFTGAERARLLERFPDGTVEEAYVVTLRVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS38</accession>
    <name>A0A0F4IS38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-ACP synthase</fullName>
            <ecNumber evidence="5">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001252">
        <property type="protein sequence ID" value="KJY24298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951820.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001252.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24298">
        <property type="protein sequence ID" value="KJY24298"/>
        <property type="gene ID" value="VR44_35765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4307"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="8"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="41151" checksum="0E68DD2E503543C4" modified="2015-06-24" version="1">MGKDISGVCVTGMGATTPLGGDAVTTWRAMLRGENGIRAIEEEWAASLPVRIAGRVRRDPAEVLDRVRARRLDRCEQLALVAAREAWADAGRPQVEPERLAVVIGTGTGGALTLLGQDDVLEASGVRKVSPHTVPMLMANGPAAWVSIELGARGGAHTPVSACASGGEALALALDLIRLGRADVVVAGGTEACVHPLPLAGFAQAKAHSTRNDAPEAASRPFDTGRDGFVIGEGAGLVVLERAEFAAARGARVYARLAGAGVTSDAHHITAAHAPGQVRAIRTALASAGLAPADVALVLAHATSTQAGDLVEARSVEEAVGTHAAVTATKSMTGHLFGAAGAVGAVAAVRAVYEGVVPPTRNLESQDPEIGLDVVAGAARRMPVPAALANAFGFGGHNAALVFTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISN9</accession>
    <name>A0A0F4ISN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001379">
        <property type="protein sequence ID" value="KJY23726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952137.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001379.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5670"/>
    <dbReference type="EnsemblBacteria" id="KJY23726">
        <property type="protein sequence ID" value="KJY23726"/>
        <property type="gene ID" value="VR44_37470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4913"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22171" checksum="685FF4748DEE5B9C" modified="2015-06-24" version="1">MTQASEAARAPIRILLAEDQSMVREALAALLGLEPDIEVLAQVARGDEVVPAALAHDVNVALLDIEMPGMTGIEAAQALRRARPGMKIVVVTTFGRPGYLRGAMEAGASAFLVKDAPAAELAEAVRRVLAGERVIDPGLAAAALAEGANPLTEREREVLRAAEHGATNAELAAALSLSQGTVRNYLSTAIQKLAARNRAEAVRVAREKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISP8</accession>
    <name>A0A0F4ISP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001376">
        <property type="protein sequence ID" value="KJY23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23736">
        <property type="protein sequence ID" value="KJY23736"/>
        <property type="gene ID" value="VR44_37435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7401" checksum="239C7970C4DFE159" modified="2015-06-24" version="1" fragment="single">TEAFPAFTEPSGPVGPSGPTGGPALGTVPVGAEETPRWPGPEALDSPAVPRPGPAAPPPGPRPPLPTPAPAGKSGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITQ5</accession>
    <name>A0A0F4ITQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001081">
        <property type="protein sequence ID" value="KJY25392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951238.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001081.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25392">
        <property type="protein sequence ID" value="KJY25392"/>
        <property type="gene ID" value="VR44_32590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3329"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15001" checksum="2BAB3D1D46304B1F" modified="2015-06-24" version="1">MTTHSTHSSIEHHPDLAEMRTRFERVTVTPAAQAVEALALITGLYLAASAWIAGFSALSPLAINNLIAGAAFCLCMGGLGSAYERTHAMAWTAAAIGAWTIVAPWVMAGAMDTTRSVASNVITGAVALCLALAMVAMGGRPRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU01</accession>
    <name>A0A0F4IU01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951370.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25129">
        <property type="protein sequence ID" value="KJY25129"/>
        <property type="gene ID" value="VR44_33305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469825" evidence="1">
        <location>
            <begin position="27"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="361" mass="35637" checksum="958C3285B298114B" modified="2015-06-24" version="1" fragment="single">MNVRRSAAALAASAVLCVGAAPAALADTPPPAPSAPPVIPSGLFGKADPSYDGVWRQSFALLAQQTVGEKPAPQAVDWLTGQQCANGGFASFRADATKACDATTVYDTNATAVAVQALKALGGKDAQVKKATDWLKSVQNEDGGWAYVPGSPSEGSSTSIVISALAVAGEKPAEVKSKAGKSAYDGLLSFQLGCSAEPAGDRGAFGYQPADGKLAANADATAAAVLAGLGKGTLVEPATTDTPTAPLACPAGAADPAAAAQAAAGYLAEALKKDGHLTAVTPGADQPTPDTGNTADAVIALAAAGHRQAAAGALEWLKNNSASWSNRNPAALATLVLTAHATGTDPKAFGGVDLVAALNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUC7</accession>
    <name>A0A0F4IUC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001124">
        <property type="protein sequence ID" value="KJY25078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25078">
        <property type="protein sequence ID" value="KJY25078"/>
        <property type="gene ID" value="VR44_33505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3581"/>
    <dbReference type="eggNOG" id="ENOG5033S9V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="23773" checksum="01C37E064A440A05" modified="2015-06-24" version="1">MGAQPAEAPDATAPQPEPAAPPADATAPVPAARRAAEGYLKAEFPWYGLDGAFTGPRWLMQVGTGADGTVEHGSTGHGDEPSVRGEIATGEKERFAVVVTVASNPLRRSGDGTGVLEATSVSSAAWLAGSGLLAYSWPPQMDHSLRDDWLDQQTEAAWELADDLTGPDWSTLSLPVDGEPTPFHYRESEFGWVLAGSTGSGVHLGAYGRGMSAYGLGFSAIADLAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVI1</accession>
    <name>A0A0F4IVI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951201.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25468">
        <property type="protein sequence ID" value="KJY25468"/>
        <property type="gene ID" value="VR44_32395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3282"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="22679" checksum="5C573FB4E58191F6" modified="2015-06-24" version="1">MGGHQDRTRAAYDGVVELYASLFADRLETRPLDRAMISTFAELVRATGNPQAADAGCGPGHLTAMLHDLGLDAFGLDLSPAMVAHARRAHPGLRFEEARMESLPVEDRALGGVLAHYSTIHTPPAELPALLAEQARVLAPGGLFLVSFLALPEGPDPVRFDHKVAPAYSWPADRYAELLAKAGLTTFARLLHDPSSERGFLEAHLLSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVP9</accession>
    <name>A0A0F4IVP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001171">
        <property type="protein sequence ID" value="KJY24771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951557.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001171.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24771">
        <property type="protein sequence ID" value="KJY24771"/>
        <property type="gene ID" value="VR44_34325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19755" checksum="09BEFF6D57EA1684" modified="2015-06-24" version="1">MTEDEVADAERELGVRFPAEYRAYLRDAPDGAAYRVVRTEAGWRWPGDRRLRSDLLAVPFPHPDSYVEADAALCAREPLAADFPDDAAYGAAWEAWDAECEEFEDWRTAGAMLLEEHGCGFATLLVVTGPLAGTVWWDGRASCDRIVRLSLDHGGGGEPVTFAEWLGRGSWDLLPPGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVU0</accession>
    <name>A0A0F4IVU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001029">
        <property type="protein sequence ID" value="KJY25754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene815"/>
    <dbReference type="EnsemblBacteria" id="KJY25754">
        <property type="protein sequence ID" value="KJY25754"/>
        <property type="gene ID" value="VR44_31715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3053"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="21608" checksum="499571D29EBEC5AC" modified="2015-06-24" version="1">MVARFYDPTSGRVTADGTDLRELDLTAYRHRLGVVPQESYLFPGTVRDAIAYGRPEASDAEVEAAARAVGAHDMIATLDGGYLHTVTERGRNLSAGQRQLIALARAELVDPDVLLLDEATAALDLATEAQVNQATDRLAGKRTTLVVAHRLTTAARADRVVVMERGRVVEDGSHAELLAKGGRYSVLWRTFAGEEEPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWD1</accession>
    <name>A0A0F4IWD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_31635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001025">
        <property type="protein sequence ID" value="KJY25778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001025.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7094"/>
    <dbReference type="EnsemblBacteria" id="KJY25778">
        <property type="protein sequence ID" value="KJY25778"/>
        <property type="gene ID" value="VR44_31635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3035"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="27376" checksum="8AE381F27AE4C634" modified="2015-06-24" version="1">MADSFGPVRGDDGAGCRAAAVTADPAEAGELAGEPIRVLVVDDHALFRRGLEIVLAQEEDIQVVGEAGDGAEAVDKAADLLPDIVLMDVRMPRRGGIEACTSIKEVAPSAKIIMLTISDEEADLYDAIKAGATGYLLKEISTDEVATAIRAVADGQSQISPSMASKLLTEFKSMIQRTDERRLVPAPRLTDRELEVLKLVATGMNNRDIAKQLFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX32</accession>
    <name>A0A0F4IX32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">VR44_33000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01001102">
        <property type="protein sequence ID" value="KJY25241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951311.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25241">
        <property type="protein sequence ID" value="KJY25241"/>
        <property type="gene ID" value="VR44_33000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3472"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY25241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="36183" checksum="860495E643AFAE75" modified="2015-06-24" version="1">MTRIFSGITPSGHLTLGNYLGALRQWVAAEHSPSDALFCVVDLHALTVEHDPARLRRLTRQNATLFLAAGLDPRRCTLFVQSHVAEHTRLSYLLECTATDGELRRMIQYREKAAKAEAAGQGVRLSLLTYPVLMAADILAYAADEVPVGEDQRQHVELTRDLAVRFNQRYGHTFTVPKATLPTVGARVMDLQDPTSKMGKSSENTAGIVYLLDEPAVITKKVMRAVTDSGEGGVVYDRATRPGVANLLDVLAACTGGDPEKLAEGYAQYGPLKRDVAEAVVELLRPLRERHAGLAADPGEVERVLREGAERARAIARPVVDRAYEAIGLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXJ2</accession>
    <name>A0A0F4IXJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000948">
        <property type="protein sequence ID" value="KJY26374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26374">
        <property type="protein sequence ID" value="KJY26374"/>
        <property type="gene ID" value="VR44_30205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2448"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="44388" checksum="EFA46F84CB29F8A1" modified="2015-06-24" version="1">MIAQLRRPPGGRDARIMLLAQLLDRTGTGVWAASSVLFFTFVVGLDAGRLGVMLGVGAIAGIAGSPLAGHLADRFPVRPLLIACHLLRLAALCAMLVVTRFELLLLIVALTQLGDRAAKTLEMLFATRVAGERRATYQALSRSAANAGYAVGAGIAAIGLAVGTRDAYEVLILGNALSFLAASLLIWRTREPHGHGRLVAAATRPAGEGGDQDGTAPAAGSGPARRSPWRDRGYLRFVLLDMPLNLDDSLLNVGLPLWLVHHTDAPHAVVPAFLALNTVLVVVLQLTVSAKVSTPRQAAGAVAWYGLFLFAACALLALTPAHGPRTASATLLGAAVLVTAAELVRSVCSWELAVSLAPQEARAAYLGVAGISPSAQKAAGPLLLTGAVMAAGPAGWLALGAGVTALALLQRRTALHRLDTVRPAPAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY72</accession>
    <name>A0A0F4IY72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000883">
        <property type="protein sequence ID" value="KJY26942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950541.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000883.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26942">
        <property type="protein sequence ID" value="KJY26942"/>
        <property type="gene ID" value="VR44_28795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2099"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="40"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="187"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="38956" checksum="4853D813CAD4FEEB" modified="2015-06-24" version="1">MEAERHSDPGDVFAWIDDSTRRRDRAGLTRRVQVRGARPDVIDFGGNDYLGLTRHPRVVQAVADASLTWGAGSTGSRLATGTTEVHAELERELAEFSGAEAALVFSSGYLANLGAVTALARPGTLIASDAFNHASLIDGYRLSGADVVDIAHADPQALERVLAEREQQRALAVTESVFSVDGDLVDVDDAHGLGVIGERGEGAVAAAGLAGSPDVVTTITLSKSLGAQGGAVIGPRRVIDHVMNMARSFLFDTGLAPASAAGALEALRVLRAEPDRPARTRHVAATLAERLAAIGLPVTEAQAAVVSVRGPSAAQTAKWAADCLADGVKVACFRPPSVPDRFSRIRLTSRADLTESEIDRAIDVVVKHSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYA1</accession>
    <name>A0A0F4IYA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000914">
        <property type="protein sequence ID" value="KJY26644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950679.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000914.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26644">
        <property type="protein sequence ID" value="KJY26644"/>
        <property type="gene ID" value="VR44_29550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2285"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="29210" checksum="8D7514B1E57BB5C2" modified="2015-06-24" version="1">MSRTHQTAATLTTSDADLLAQTVGAVRTAGSALRERFGEVVRYDTRQELTRALAVNDDTALGILRPRLTRLRPNAGWVEDELDGGALPSGEWWVVDPAEGNVNHLHALPEWAVTATLVRENEPVLTAVHLPLTGETYTALSGAGAHLDGRPLHVSQAAHLDLSIVATSQARPDEDEDVVRRVGASITAMLFDALVVRTAVPATLHLANVASGRADAFWQFAGARADLLPGALLVREAGGRVSDVEGRPWTPQSDSFLAAAPGVHAQAAATLSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYY5</accession>
    <name>A0A0F4IYY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000911">
        <property type="protein sequence ID" value="KJY26683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950669.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000911.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26683">
        <property type="protein sequence ID" value="KJY26683"/>
        <property type="gene ID" value="VR44_29475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2261"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="7636" checksum="35D282B64D83AED7" modified="2015-06-24" version="1">MRYEFRITGRVSEPVSHAFPELREFPAARQTLFFGTVTDEAHLYGLLGRFRDLGLHVEEMRRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ22</accession>
    <name>A0A0F4IZ22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000889">
        <property type="protein sequence ID" value="KJY26904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26904">
        <property type="protein sequence ID" value="KJY26904"/>
        <property type="gene ID" value="VR44_28935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="21947" checksum="F9C8AC1A6D52D937" modified="2015-06-24" version="1" fragment="single">MRGDAEPRWSVRGEHRERARLRLYCFHHAGGSASEFARWHRYLPEDVDVCAVQLPGRGARIKEPAHTRMRPLVEELAGQLETDLPMVFFGHSFGALVAFELARALTEAGGPVPRHLFLSARPAPGLVSYRGRIHDLPEEEFLDVMDGRHGGVPAELREHPELRAMVLPYFRADYEVIETYRPVAAAPVPVPATVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZD2</accession>
    <name>A0A0F4IZD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000843">
        <property type="protein sequence ID" value="KJY27372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950353.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000843.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27372">
        <property type="protein sequence ID" value="KJY27372"/>
        <property type="gene ID" value="VR44_27760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16983" checksum="1012B758AD911FA8" modified="2015-06-24" version="1">MGKLTVGALRAVLGVVLAGTAFVQALMVWTLVSGSDPEDGSMPLTALRVVTVLGMVSVQVALVCVWRLVTMVRRGTVFSHAAFRYVDGVIGAIVAAALVWFSVTAINAPGQREDPGVTVIMGGVGVAILGVALIVLVLRMLLAQAVARDAEATQMRAELDEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZI5</accession>
    <name>A0A0F4IZI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000985">
        <property type="protein sequence ID" value="KJY26086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950928.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000985.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26086">
        <property type="protein sequence ID" value="KJY26086"/>
        <property type="gene ID" value="VR44_30900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2684"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="19384" checksum="424E0F1794AA18E0" modified="2015-06-24" version="1">MIVWLNGTHGAGKTTTSMFLQQLLPDSRVFDAEKVGETLMDIQPGLPATDNFQHWPPWRPLVVETARRILDYTGGTLVMPMTVLVEKYWREISSGLAEHDIPVRHFVLHADQGTLRARIAGDTLLGPNSPFRLAHLEPYAEAARTWLHDEAEVVDTTHLTPAQAAQQIAEAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZL8</accession>
    <name>A0A0F4IZL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage-related protein, tail component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000979">
        <property type="protein sequence ID" value="KJY26126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950910.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000979.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26126">
        <property type="protein sequence ID" value="KJY26126"/>
        <property type="gene ID" value="VR44_30815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2620"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25938" checksum="470BABB799C15E68" modified="2015-06-24" version="1" fragment="single">AATESGRLGLGIPGYAHPLLAPVEWAELTRPGTPLHWAVLNVSDGPGGRPDPHCGEAAGRLRGAGGTVLGHLALRGGTRPFGELVSDAHRFRDWYGVGGFYLAEAPADRADLAGIRRLTDALRGLGEGLRIVLGHGTHPCEGYLEAADQLVTFSGAWTDYRWSQVAEWTADHPPERFCHLVHGVPRTHLEEAVRIARWQGAGTIWFTDRRATPDRDPWESMPAYWDEFVSRIGPGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZR0</accession>
    <name>A0A0F4IZR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950460.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000866.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27144">
        <property type="protein sequence ID" value="KJY27144"/>
        <property type="gene ID" value="VR44_28365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="145"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="27135" checksum="8DAA4B8513FAC6A3" modified="2015-06-24" version="1">MKITEYVETLAREGELLADEAERAGTEALVPTCPEWRVSDLLRHTGAVHRWAAGYVREGLVEPAPFPEAPELVGAELLSWFREGHAELVRALAEAPEELLCWTFLPTAPPSPLAFWARRQAHETAVHRFDAQAARGIAFSGVTPEFAEDGVDELLTGFHARPRSRVRTEEPKTVRVRAADTGAVWTVHLSKEPARTVRGDTGDPADCELTGEASWLYAALWNRLPLAGPGVSGDKELARLWQDTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZW4</accession>
    <name>A0A0F4IZW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000822">
        <property type="protein sequence ID" value="KJY27547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27547">
        <property type="protein sequence ID" value="KJY27547"/>
        <property type="gene ID" value="VR44_27310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="200" mass="21357" checksum="52EA408E97E1AC65" modified="2015-06-24" version="1" fragment="single">MGTHEHALDVVVYYHHPDKAPLLRGALLPLAEACAARGTAAHVERHWLHGPHLRLRLQGPPRQVEEASESAASALRDWLREHPSHGDLTETELLERAALAGRAELVPPPYGPIEPDNTVRIQAVDRSSVRGLLGEDGAALREDLLRAGLGALRAGAGFLGEHGDGERARIRLAVTALAAHAGAHPGGLAGGHWSYVSHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0M0</accession>
    <name>A0A0F4J0M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950152.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000793.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4839"/>
    <dbReference type="EnsemblBacteria" id="KJY27827">
        <property type="protein sequence ID" value="KJY27827"/>
        <property type="gene ID" value="VR44_26655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1490"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="35404" checksum="83A6E1396B459226" modified="2015-06-24" version="1">MAAVKMSIAKALNESLRKAMDTDPKVLIMGEDVGKLGGVFRITDGLQKDFGEERVIDTPLAESGIVGTAIGLALRGYRPVVEIQFDGFVFPAYDQIVTQLAKMHARALGKIKLPVVVRIPYGGAIGAVEHHSESPEALFAHVAGLKVVSPSNASDAYWMLQQAILSDDPVIFFEPKRRYWDKGEVDTDAIPGELHKARVVREGADLTLAAYGPMVKVCLEAAAAAAEEGKSVEVLDLRSMSPIDFDGIQASVEKTRRLVVVHEAPVFLGTGSEIAARITERCFYHLEAPVLRVGGFHAPYPPARLEDEYLPGLDRVLDAVDRSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0S0</accession>
    <name>A0A0F4J0S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000788">
        <property type="protein sequence ID" value="KJY27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950128.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000788.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27880">
        <property type="protein sequence ID" value="KJY27880"/>
        <property type="gene ID" value="VR44_26535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1431"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="339"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="46231" checksum="3168A20E7761D279" modified="2015-06-24" version="1">MRYDSITEAIGGTPLVRIDPAVHGLRHMLNPFGSLKDRAAWNMTRDGLAGAAQRGETVVELSSGNTAKALALIAGLHGLPFKSVTNRMRIPEVKDLLLLLGAEIEELPGRSECLDPTDEDDPLTLFHRQLNLPGSAHLHTDQYFNALNTEAHASGTGPEIIADLDGRAPDWFVACVGTAGSSTGVARALRAHDPAVRVVGLVGEKSDFIPGIRTIDEVQEVGIFDPSTYDALEPVGSDEAIEGMLTLLRRCGLLAGPTGGAAYFGAVRHLRELDAGLTERRTAVFIVCDRVESYVGYIRRRRPDLLGLPPMRNSVATLTAAEAASAAVIGVDEARKWIAERQPLVVDLRGPFAYAALHIEGSVNIVDELFDELLRGGLPFGRSRPVLLACPVGEKSARYAALLTRMGHPDVRSLAGGIIAWRDAGAPLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J149</accession>
    <name>A0A0F4J149_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000773">
        <property type="protein sequence ID" value="KJY28005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28005">
        <property type="protein sequence ID" value="KJY28005"/>
        <property type="gene ID" value="VR44_26280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1414"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="486" mass="49431" checksum="3CE3E9D53C5E312C" modified="2015-06-24" version="1">MARLDAPAGGREGAGYGPEGTVLITGGTGTLGRLVARHLVASYGVRHLLLTTRTGPDAPGARELVAELAGSGATATVAACDTADRAALAAVLASVPAERPLTAVIHAAGVLDDGVLTSLTGERADAVLRPKVDAALHLHELTRDLDLAEFVLFSGAAGTFGTSGQAHYAAANVFLDALAAHRRASGLPGTAVAWGFWAERSAMTGHLDETAVRRLGRAGIAEMSSAQGLAFFDAAHGTGECPVLALKLETAALRERAAAGTLPALLRGLVRVPARRAAAVGAQGAEGVRAAAGAGPETAGPALADRLAGLPEAERTERLVELVVGQVAAVLGHASAAQIEPEQAFKALGFDSLSAVELRNRMNRATGLRLSATLAFDHPTPLALAAHLGEELARSRRPSADRVLAGLGLVDDLLSSVSGTDGDRSRIVSRLLELAAKYAGSGADPTAVSTASVPFLSADSSENPDTPVSIESASDDELFALIDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2H8</accession>
    <name>A0A0F4J2H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000867">
        <property type="protein sequence ID" value="KJY27136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950468.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000867.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27136">
        <property type="protein sequence ID" value="KJY27136"/>
        <property type="gene ID" value="VR44_28400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2005"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24438" checksum="AB419C698C586ABE" modified="2015-06-24" version="1">MDLVEVLPNRLHMLRFPIGQAYLWQDRAGEALTLIDSGPSGAADAIEGAIRSLGLAPERLERIVLTHCHRDHVGSAGELAARRGAEVLAHRLDAPVVRGEQPVPEPVLLDWEVPLYAHGMTVPEAPPTPVDRELEDGEVLPFGGGAVVVHSPGHTPGSIGIHLPEHGVLFTGDCVAGVGEVMLGVFNTDRAQAIATFHRLAALSPTVACFGHGDPRTENTAQALKEAAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J322</accession>
    <name>A0A0F4J322_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000705">
        <property type="protein sequence ID" value="KJY28747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene2991"/>
    <dbReference type="EnsemblBacteria" id="KJY28747">
        <property type="protein sequence ID" value="KJY28747"/>
        <property type="gene ID" value="VR44_24655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.927"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10410" checksum="23643A3BED7FD756" modified="2015-06-24" version="1" fragment="single">SFVARLAVDAQDAEIVRCTVDLAHSLGLLVVAEGVEDDETWERLRDLGCDAVQGWLVAAAMPPQEATAWLLARGERGWRRPADITAELAATADTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3E2</accession>
    <name>A0A0F4J3E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000702">
        <property type="protein sequence ID" value="KJY28780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949759.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000702.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28780">
        <property type="protein sequence ID" value="KJY28780"/>
        <property type="gene ID" value="VR44_24555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.906"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="25769" checksum="104AB425976EA498" modified="2015-06-24" version="1">MHGNGWPANELEQTLGTALGQPDAGPRILEALGRSQVWIPLPQGGGPDSTSLDLPTMLIAGEAYVPVYSSEAQFRFAAGPAMDFAVAPAVEFARGLPPQLGIAVNPEGAVGVPLPPAAVAQLCRAGRTELDGPASGARVRLFEPDWQDDPVDFLAAAAEEFRATGVVTAAHRCLASVEGKAPELYIGVQLVGWDSGTRTAPLEALGRALARVPAPWPVQLILLEAADDPVTDWIRERVRPFYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3G6</accession>
    <name>A0A0F4J3G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_25850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000750">
        <property type="protein sequence ID" value="KJY28238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28238">
        <property type="protein sequence ID" value="KJY28238"/>
        <property type="gene ID" value="VR44_25850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1274"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="98"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24100" checksum="FF5C00661075718F" modified="2015-06-24" version="1">MFWCAAVAVALCYGISCGHLPAFGGPFHPYADRAVPTALARRTANAVASVNFDQRGFDTLGEEFILFTAVLGAAIVLRRARDEHVVSPRSGRVLPTVRLAGTVLLPVALVTGVYVVAHGQLTPGGGFQGGVVLATGLHVAYLAADYRVLRAVRPRTVLDLADAMAAGAFAALGLAGLAWGSAYLENVLPWGTLGQLTSGGIVPLLNAAVGVEVGSALVVLLAAFLDQALEIETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3M8</accession>
    <name>A0A0F4J3M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000695">
        <property type="protein sequence ID" value="KJY28890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949697.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000695.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28890">
        <property type="protein sequence ID" value="KJY28890"/>
        <property type="gene ID" value="VR44_24215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.823"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="20922" checksum="2F9F6EB99B30E9AF" modified="2015-06-24" version="1">MGHREDLLEGAKKCLAEKGFVRTTARDIVSASGTNLASIGYHYGSKDALLTQAFIALIEEWGEGRQAGLEGAEGSLERHRALWDGVVAEHTAAGPVWAASLEVALSRDQKPELKSMLAASQLEGRRGLVSMMTGTPEEQLTDRDERTLGAVYQALLNGLMIQWLFDPSAAPSGEEFTEGLRRLAEGITGAPRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4T0</accession>
    <name>A0A0F4J4T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000700">
        <property type="protein sequence ID" value="KJY28819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949743.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000700.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene801"/>
    <dbReference type="EnsemblBacteria" id="KJY28819">
        <property type="protein sequence ID" value="KJY28819"/>
        <property type="gene ID" value="VR44_24470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.889"/>
    <dbReference type="eggNOG" id="ENOG50343N9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="7832" checksum="7B9136CD92008D26" modified="2015-06-24" version="1">MSDRQLWSYKEIAAHIRVQPDTVRSYRKHGLLPAPDHVESGKPYWYADTIRAWVARRPGNRGRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J596</accession>
    <name>A0A0F4J596_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_24205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000694">
        <property type="protein sequence ID" value="KJY28923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949696.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000694.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28923">
        <property type="protein sequence ID" value="KJY28923"/>
        <property type="gene ID" value="VR44_24205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.793"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045980">
        <property type="entry name" value="DUF5936"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19359">
        <property type="entry name" value="DUF5936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5936" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="296" mass="32116" checksum="AEEEB7E4B6C9E389" modified="2015-06-24" version="1">MPLLLAAVTGLAVFGILHGIRLYRADVELPTDLALALEVGSSRTTAVGSVVDRLGIRWAPLVLRLMGPTRVARKRAQIDRAGNPAGLTIDRYAARRAVYGFLGGLGALAMLLNGQLVVALLMVAFGLFWIEAGLWSAIRVRRDDIERTLPDFLDVLAVVVSAGLGFRQALERVAAKYEGPWADEVRITLQQMDMGVSRRQAFDELRRRNDSEQVAQFVTALQQGEELGSPIVDTLIAIAEDMRRTDAQNARRRAARAVPKATFAVTMFMLPGTLILLVCGFVYGANVDFGALLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6E9</accession>
    <name>A0A0F4J6E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsule biosynthesis protein capC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000605">
        <property type="protein sequence ID" value="KJY29917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949225.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000605.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29917">
        <property type="protein sequence ID" value="KJY29917"/>
        <property type="gene ID" value="VR44_21660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.210"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008338">
        <property type="entry name" value="Capsule_biosynth_CapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14102">
        <property type="entry name" value="Caps_synth_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01759">
        <property type="entry name" value="CAPSULEPROTC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="16907" checksum="E4FDAE2E9B917DF6" modified="2015-06-24" version="1">MIPAVLTPEIAAIGIALGLLFSLLCYLTTNLSPGGMITPGWLALTLVEDLQRAALVLGITVLTYLLTLLTQRFVILYGKRLFAAVVLIGVLLQASVVIVLQLEFPLLYANQTLGFIVPGLIAYQLVRQPKGATLLATGSATLMTYVVLTAGILLGVMPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N5</accession>
    <name>A0A0F4J7N5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_20580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30412">
        <property type="protein sequence ID" value="KJY30412"/>
        <property type="gene ID" value="VR44_20580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8828"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="623" mass="65380" checksum="EDFE5899F9FE2DE6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J834</accession>
    <name>A0A0F4J834_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949034.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000569.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30375">
        <property type="protein sequence ID" value="KJY30375"/>
        <property type="gene ID" value="VR44_20640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8843"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="25969" checksum="E7DFE7A1FA0F1751" modified="2015-06-24" version="1">MGVASVITAALPTAPVLRSEWIKIRSARAVLGSLLAVFAATAGITVLTAAAIGTSEPGALGEDRLFGAFFGINFGQSAAVAFGATAFAAEFRGGALRVSLTAVPNRTRLYLSKAVAVAGLSFLVGQFTGLVTFVAGQAFMGEYALALGDPGTLRAVFGSGVYLTLIALLSAGLAALVRSGTLVMGLLIPFLLIVPFVVGQVMDGAGQFMPDRAGQLVMRAHAEGSLGPWSGLGVTALWTLAALAGGWLAVRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J875</accession>
    <name>A0A0F4J875_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000553">
        <property type="protein sequence ID" value="KJY30592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948928.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000553.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30592">
        <property type="protein sequence ID" value="KJY30592"/>
        <property type="gene ID" value="VR44_20055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8633"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="320" mass="34419" checksum="70E7E245E911AD53" modified="2015-06-24" version="1">MTAASPPEVLRAPLVVEFPFTRSLGPVQSAFLTGLREGVVLGVRTSGGQVMVPPVEYDPVTAEELRELVEVAPTGTVTTWAWNGEPRPRQPLGTPFAWVLVRLDGADTALLHALDVPGPDAVRTGMRVRVRWAAERTGAVTDIACFEPYEGEGKAGGAAPHDGVFDEPVTGIVAEARLDYTYSPGRAQTAYINALSERRTVGERCPSCHKVYVPPRGACPTCGVATTDRVEVGPAGTVTTFCIVNIKAKNLDIEVPYVYAHIALDGAGLALHGRIGGIPYDQVRMGLRVEPVWTDGGRYPDHYRPTGEPDADYDAYKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J882</accession>
    <name>A0A0F4J882_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949197.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29953">
        <property type="protein sequence ID" value="KJY29953"/>
        <property type="gene ID" value="VR44_21520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="14064" checksum="67917849CFBF02FE" modified="2015-06-24" version="1">MFAEIAFLLYVGHLLADYPFQTDHQAAHKAKCGRQGWTANVTHAATHLLTCGAMLTLGTVLLGWHLPLLPTAGALLWIGVTHGFIDRRWPIAAWMRIARQQGWAAHGGAAHVDQTAHVLALTLAALFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8M7</accession>
    <name>A0A0F4J8M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000541">
        <property type="protein sequence ID" value="KJY30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30747">
        <property type="protein sequence ID" value="KJY30747"/>
        <property type="gene ID" value="VR44_19560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="175" mass="18387" checksum="F2B81197469989C1" modified="2015-06-24" version="1" fragment="single">MGRAENHDEDLAELREAWRWSGLLSHDALPRPGQPSGGQSGGLPQEITSRLDDVRERIALLPPHTDGGGPEPSGPGNVLVIAALLMAGAEARKRPVVRVPVVFGQSADGPGRAEPEQGVSGVLELREFPAGPAGLYPDPRTMAGTHSPNGQFATAVGRAWRAAGAGPESRCVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB87</accession>
    <name>A0A0F4JB87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_19015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948735.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000520.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31064">
        <property type="protein sequence ID" value="KJY31064"/>
        <property type="gene ID" value="VR44_19015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470897" evidence="7">
        <location>
            <begin position="38"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="299"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="496"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="754"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY31064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="839" mass="85632" checksum="308848E50E6CB944" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC34</accession>
    <name>A0A0F4JC34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000559">
        <property type="protein sequence ID" value="KJY30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30521">
        <property type="protein sequence ID" value="KJY30521"/>
        <property type="gene ID" value="VR44_20275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8764"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16317" checksum="36E7DF71E4D1296A" modified="2015-06-24" version="1">MDLATVIDRLAVDEVVSGYAAAVDDGDWAAYRALFTPGGRADYSSAGGVEGPAGEVADWLAETMRLFPVRQHLIVNRRILLEDRDGFPGDRARVLADFLNPMRLAGDGDRGTAPNFVAAGRYTFTLARTPDGWRLTGVTVHEKWRHMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC68</accession>
    <name>A0A0F4JC68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31927">
        <property type="protein sequence ID" value="KJY31927"/>
        <property type="gene ID" value="VR44_17105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7953"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="319" mass="33085" checksum="CD99751A6B758B50" modified="2015-06-24" version="1">MSGVVDLAAVKAAGEAKAKAEQARAEAARQGGGAPGGAVPPSALVIDVDEAGFESAVLQLSNEVPVVLDFWAEWCEPCKQLGPLLERLAVEANGRFVLAKIDVDANQMLMQQFGIQGIPAVFAVVAGQVLPLFQGVAPEQQIRETLAQLVQVAEERFGILGLQVDPDASGAPAAPAPVPAGPYDALLEAAVVALDAGDLGGAVQAYKNVLADDPANSEAKLGLAQAELLSRVQHMDPQAVRTAAAENPRDPAAQMAAADLDLAGGHVADAFSRLVDTVRVTAGDERDSVRVRLLELFEVIGADDPRVTAARTALARVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCP7</accession>
    <name>A0A0F4JCP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_17070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="JZWV01000451">
        <property type="protein sequence ID" value="KJY31965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948368.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7020"/>
    <dbReference type="EnsemblBacteria" id="KJY31965">
        <property type="protein sequence ID" value="KJY31965"/>
        <property type="gene ID" value="VR44_17070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7946"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY31965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="431" mass="45574" checksum="EB57E212E0038416" modified="2015-06-24" version="1" fragment="single">VPSTALFTDHYELTMLQAALANGTADRRSVFEVFTRRLPEGRRYGVVAGTGRVLDAVENFRFDGAVLEFLRERAVVDMRTLDWLASYRFSGDIWGYPEGEVYFPGSPVLRVEGSFAECVLLETVILSILNHDSAIAAAASRMASAAGGRPLIEMGARRTHELAAVAASRAAYVGGFTSTSDLAAGFRYGIPTVGTSAHAFTLLHDTERDAFTAQVASLGSGTTLLVDTYDVAEAVRTAVEVAGTGLGAVRIDSGDLLLVAHRVRQQLDELGATETRIVVTSDLDEYAIASLAAAPVDAYGVGTQLVTGSGHPTCSMVYKLVARAESADPKAPLAPVAKKSSGGKTSMGGRKWAARRLDAEGVAEAEVVGTGPVPTALADRQLLVQLVKAGEVVAREPLDTARTRHERSRAGLPLSATQLSRGEPVIPTEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD63</accession>
    <name>A0A0F4JD63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000475">
        <property type="protein sequence ID" value="KJY31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948477.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000475.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31678">
        <property type="protein sequence ID" value="KJY31678"/>
        <property type="gene ID" value="VR44_17670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8031"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="15750" checksum="E2C86F702CE2E4AE" modified="2015-06-24" version="1">MTFIRVRAGRWLALARQDRGSETIAAAIVTPLLIMLLCLAIAGGRIVTSGAKIDAAAEDAARAASISRTYTGAQAEASAAATRSLDDQGIHCASVSTSVDVSGLAVPLGQAGTVTVTITCNVTMADLLLPGVPGSKTLTSRFTSVVDAYRSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDW2</accession>
    <name>A0A0F4JDW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">VR44_17140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000454">
        <property type="protein sequence ID" value="KJY31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948379.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000454.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3060"/>
    <dbReference type="EnsemblBacteria" id="KJY31923">
        <property type="protein sequence ID" value="KJY31923"/>
        <property type="gene ID" value="VR44_17140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7960"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="36521" checksum="5D2D00FA15BA0EFF" modified="2015-06-24" version="1">MRIGVLTAGGDCPGLNAVIRSVVHRALVGHGDEVIGFEDGFKGLLDGHYRPLDINAVSGILARGGTILGSARMERARLHEAAENAAELARRYQLDALIPIGGEGTLTASRMLSDAGMPVVGVPKTIDNDISATDRTFGFDTAVTVATEAIDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERPFEVDALVKMVEERFARGKKFAVICVAEGAHPAEGSMPYEKGAIDAYGHERFAGIGNRLAGELEHRLGKEARPVILGHVQRGGVPTAYDRVLATRFGWHAVEAVHRGEFGNMTALRGTDVVMAPLAEAVTELKRVPENRMYEAESVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEV2</accession>
    <name>A0A0F4JEV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948554.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000491.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31481">
        <property type="protein sequence ID" value="KJY31481"/>
        <property type="gene ID" value="VR44_18080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8163"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="88"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28722" checksum="AC1853F0DE514971" modified="2015-06-24" version="1">MASGGRKKDQRRGARERLLAERETQERRRRLRGRLLVGGALAAALVIAAGVGIYASRSAGSGAGSEAGGKPFVRPAHTAGEDGVVVPYGREDAKDVVSVWLDPRCPFCAGVETGLGPTFKERAAAGDYRVEYHFATFLDGALGGKGSKRALNALGAAVNESPEKFMDYLQVLYGNHPEKESDDTFGSTATLLDLADRVPGLRNPGFDKAVKELTYMPWVDRVSKAFYGSGKKGTPVVEVNGKEVDVLTGKGLETVTPEAFGRLVAANPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG78</accession>
    <name>A0A0F4JG78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-glycerol:glycerophosphate glycerophosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_14080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947821.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2575"/>
    <dbReference type="EnsemblBacteria" id="KJY33357">
        <property type="protein sequence ID" value="KJY33357"/>
        <property type="gene ID" value="VR44_14080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7129"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="956" mass="107050" checksum="E37E7484D8854207" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH04</accession>
    <name>A0A0F4JH04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947787.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000355.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33470">
        <property type="protein sequence ID" value="KJY33470"/>
        <property type="gene ID" value="VR44_13910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7068"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="203"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="35309" checksum="DA66B2CBB5566069" modified="2015-06-24" version="1">MPAVTVENPLALPRVIAPAEGAQARPVLGVVDAPSGFEGEGFPVRRAFAGIKYEYLDPFIMMDQMGEVDYAAGEPKGTPWHPHRGFETVTYIIDGTFIHRDSHGGGGVITNGDTQWMTAGSGLLHIETPPEELVMSGGLFHGLQLWVNLPASDKMLAPKYQDIRGGTVKLLASQDGGALIRLIAGDLAGHAGPGATHTPITMIHLTVSPGAEVTLPWRADFNALAYGLAGSGAAGAERRPFKMGQTVVFGSGDGLTIRADAAQDSRSENFEVVVLGGLPIREPMAHYGPFVMNTHAELQQAFDDFQAGRLGVIPSTDVTGLGHRGAGQADPEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH42</accession>
    <name>A0A0F4JH42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33124">
        <property type="protein sequence ID" value="KJY33124"/>
        <property type="gene ID" value="VR44_14460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7153"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="43127" checksum="85D54619C48192ED" modified="2015-06-24" version="1">MDRHAPRPETRLEPLPPLLPAPPGAPDPAEVDPRVLGALLHRHGWLRRGGAAGRYGRWTPPGHAGTSLLVPETRTFPDCADLLEEALTALSRSGLPSAREVLFGLSLPSDEVRWEREIPEAPYGFQGEAAWSAQERLRSAARRLLLAGALAERARAGYYGARHRAQAERALDGVLVGPGPDGRRLAAYVPVDGGRGLVTRLHHALHAAREAVDYQRATGGMEAFDSAVAAGVSRELADALIALVQGSEGARVALAWAPAAGVPAGCAARPEPVEFSPGDLPVLREASARYTRAEPAVAVRLTGAVVRMRRAAAGGGGTVRLRVLAGADVPYVRAALDEEAYRIAVHAHLAGLPVRVSGRLSRRGGFRRLTDAADVTPVPLDEGERDRLIKSLDASFDPEDVLPSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHL0</accession>
    <name>A0A0F4JHL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">VR44_14190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000365">
        <property type="protein sequence ID" value="KJY33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947839.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000365.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3362"/>
    <dbReference type="EnsemblBacteria" id="KJY33299">
        <property type="protein sequence ID" value="KJY33299"/>
        <property type="gene ID" value="VR44_14190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7184"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21332" checksum="AC2D590E91E90361" modified="2015-06-24" version="1">MDSQVSQVSPDEAMRPVLEAQDIARVLTRIAHEIVERAKGADDVVLLGIPTRGVYIARRLAAKLEEITGTKIPVGSLDITMYRDDLRMKPARAIGRTEIPGDDIDGRLVVLVDDVLFSGRTIRAALDALGDLGRPRAVQLAVLVDRGHRELPIRADYVGKNLPTSLRETVKVQLQEEDGRDAVLLGQRTVQAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHS0</accession>
    <name>A0A0F4JHS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_15870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948141.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32486">
        <property type="protein sequence ID" value="KJY32486"/>
        <property type="gene ID" value="VR44_15870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7583"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="41857" checksum="58FB0D219A1FB30D" modified="2015-06-24" version="1">MDLAHTEEEQEFRARLRAWLAKVLPELPARPSPDDWPGRRAYDLGWQRRLYDAGYAGLHWPVDAGGRGATPTQHLIFLEETERAGAPYVGANFVGLLHAGPTIAAEGTAEQRARWLPPVLRGEEVWCQGFSEPGAGSDLAALRTKAVRDGDAYVVTGSKIWTSHAEVADWCELLVRTDPAAPKHKGISWLAMPMDAPGVTVRPLRTLAGSAEFAEVFLDEVRVPVANRVGAENDGWRVTMVTLSFERGTAFVGEVVACRRTLGALARAAKANGRWDDPVLRRRLGRLYGEFGALWRLTQWNVSEAQGSGGVPGVGGSVFKLAYSHARQELYDAAAEVLGAGALSLEEEWTLERLSSLSYTIAAGTSQIQRNIVAERILGLPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHX9</accession>
    <name>A0A0F4JHX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_12895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000325">
        <property type="protein sequence ID" value="KJY33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947600.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000325.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33932">
        <property type="protein sequence ID" value="KJY33932"/>
        <property type="gene ID" value="VR44_12895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6696"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="36197" checksum="EAE11FF0952863D7" modified="2015-06-24" version="1" fragment="single">LLILARALQGAAAAGMIPAALGLVLAHTPPARRAAAIGAWGAAGGLAAAVGPSLGGLLVEVWDWRAIFMVNVPLGLLVCQAARNALPREEPAGRRLPDVLGTAALALGIGALVAGLTQGAEWGWTSAPVLVLAVGGPLSIVSALHRSRRHPAPAVDRHLWRAPVFARSNVSALLFGAGMYAWLLTGPSYLMARWHYTPLEAGFGVTPGAILAMAGALVVGRRVPPRLQWAAVVLGSLLFAANALLLWGWAAHSTSYAQVFLPAGLLGGLGIGTALTALSAAASATLPPQRFAAGTGLLMTARQLGGALGVAATAALLTGEGDRWSGVFLLTALTALGAAAAGWSMRAGKKGPGPRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHY9</accession>
    <name>A0A0F4JHY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947802.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33393">
        <property type="protein sequence ID" value="KJY33393"/>
        <property type="gene ID" value="VR44_13985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20539" checksum="F14693DA182DBD9C" modified="2015-06-24" version="1">MSSGTSTAKSPRQRSRARTFLPLAVAGWLILEIWLLGLVAGAAGGLTVAALLAGGLVLGVVVIKRAGRRAFKNLTRTFQQAQEQAMAGGVPTAPQPAKGSGNGMTMLAGLLLILPGLLSDLAGLLLLLPPVRDFAARRAGSTLERKMASGTPGGFGDAYTQARIHFPDGKVVQGEVIREDGSPAGHPGPDTGYRPPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIV7</accession>
    <name>A0A0F4JIV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000342">
        <property type="protein sequence ID" value="KJY33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947702.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000342.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33739">
        <property type="protein sequence ID" value="KJY33739"/>
        <property type="gene ID" value="VR44_13435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6923"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="31768" checksum="2CBB65FA25445162" modified="2015-06-24" version="1">MREDRQQTTSSTGKKGAVGLGVLLALLATVVWSGSFVATRGMSGTVPPVQAVFWRWCIAALAVTPFAARQAWQQRALIRRHLGYISLATLFGVTLYNTLVHQAGLTTSASNMGTIMAASPVIMALYARLGGERLGARRVFGLLLAAAGVLLLVGKGSLTLDFGAGDLWMFAAAFSFATYSALLKRKPAEIGGLAFLLTTFVLGALMLAPAYAISLHVQGGFEATPATVGPLLYVGVFSSAVAFFAWNKAVSLIGAARAGVVYYLQPVCVAALGLLLLGERTGPTQLLCMALILAGVALASATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJN7</accession>
    <name>A0A0F4JJN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000281">
        <property type="protein sequence ID" value="KJY34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947370.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000281.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34547">
        <property type="protein sequence ID" value="KJY34547"/>
        <property type="gene ID" value="VR44_11665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6299"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470578" description="PG_binding_1 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="12470" checksum="320C62DF0886D213" modified="2015-06-24" version="1">MNLLPARAAASAALTVSLLLGSAAAASAASAPAEPDLTGLSCGYDNRTPPPPVTLGAKGRTVMEARCLLTFWTGLQATEEEPRDVFGPDAESATRFFQEKRGLPGTGVVDAATWTELRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJQ2</accession>
    <name>A0A0F4JJQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000322">
        <property type="protein sequence ID" value="KJY33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947593.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000322.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33993">
        <property type="protein sequence ID" value="KJY33993"/>
        <property type="gene ID" value="VR44_12860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471112" evidence="1">
        <location>
            <begin position="32"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="29601" checksum="20B03ED550ED3B65" modified="2015-06-24" version="1" fragment="single">MLHTPKPRTLRRLAALLLLAAATLHGTPAAAAGADDPGWTAEPASADGATARRPSFYLAGPAGTVLEDRLALSNTGDRERTVTLRGGDAYNTPDGAFAVRPAAASPGAGSWISFGAAATVTLPPHTRAVVPFTVTVPPASPPGDHPAAVVAAEGGHEAGVRVDLRVSGPALAALTVEEVSVRGHGAATAVVYTLVNRGNVALTPALALHAEGGLGGGSGPRTARALPVELLPGRRVTLTEPWPGAPAFGRVALRLTATAPGAAPATATTTAWFVPRGSAAWAGAGLVLLGTGALFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJW5</accession>
    <name>A0A0F4JJW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000367">
        <property type="protein sequence ID" value="KJY33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947847.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000367.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33266">
        <property type="protein sequence ID" value="KJY33266"/>
        <property type="gene ID" value="VR44_14245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7196"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="7057" checksum="6E0D052E342783D2" modified="2015-06-24" version="1">MDAFGTGQTLASKWDAGYAVVMFVKVLLGTLPDWAKWVVGSLVSVVVVLEGYRWWRRRGTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK59</accession>
    <name>A0A0F4JK59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947820.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2574"/>
    <dbReference type="EnsemblBacteria" id="KJY33356">
        <property type="protein sequence ID" value="KJY33356"/>
        <property type="gene ID" value="VR44_14075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7128"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="36443" checksum="6625DE6D6FE84914" modified="2015-06-24" version="1">MTKLSVVVPCYNEEAVIDRFDEEIRKVLDALPVEYEVCYVDDGSRDGTLGKLRKIAAEHRDRTRYVSFSRNFGKEAGMLAGLREATGDAVVIMDADLQHPPELIATMLEHYRQGHDQVIARRTREGDKKLRSALSRLYYRGVNRWVDVELTDGVGDFRLLSRPAVDALLALPEYNRFSKGLFSWIGFDTVHFDYQNAQREAGETKWKFASLLNYGMDGLISFNNRPLRIGIWLGVSLVALTGLYALWITVMAITNGIDAPGYVTIIAMIAGIGGMQMIMLGLIGEYIGRIYYETKRRPHFLVKEAHGAPVTPAPAEPVVAERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKN7</accession>
    <name>A0A0F4JKN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">VR44_12000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000292">
        <property type="protein sequence ID" value="KJY34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947434.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000292.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34389">
        <property type="protein sequence ID" value="KJY34389"/>
        <property type="gene ID" value="VR44_12000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6485"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="10752" checksum="101C03778641A523" modified="2015-06-24" version="1">MSNVSRLPGRAEHHWAWQERAACRDLGPDRFFHPAGERGEDRAERDEAAREICALCPVQVECLRHALRVQEPYGVWGGLTEEERRPLYAGAAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKV2</accession>
    <name>A0A0F4JKV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947260.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34952">
        <property type="protein sequence ID" value="KJY34952"/>
        <property type="gene ID" value="VR44_11065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6097"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="21296" checksum="0199579734025E3B" modified="2015-06-24" version="1">MRGSWKERAADHDRRSRLKKLRKAGARRLAELDLPEVTDVADLCRHLGEARERPIILVPMQMPSSHPCGMWVAARDEDLIFYDANTTSAHQEHIILHELGHIICCHRGAGGLDEAAARLLFPDLDPDLVRDMLLRATYDDVQEQEAEIIAYLLAQRMEGEQHAAHTGAEADEGGDPGTSAMLSRIERTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM41</accession>
    <name>A0A0F4JM41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000259">
        <property type="protein sequence ID" value="KJY34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947285.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000259.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34838">
        <property type="protein sequence ID" value="KJY34838"/>
        <property type="gene ID" value="VR44_11205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6251"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471178" evidence="2">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7021" checksum="9D1CC5E2D80933B6" modified="2015-06-24" version="1">MLRTRIVQAAAVAAASLTVVLIAPIASHAATTATAPAQAAATSDSLGWGGTTPTSTDSLGWGGAVQTSLGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMB6</accession>
    <name>A0A0F4JMB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AdoMet activation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35487">
        <property type="protein sequence ID" value="KJY35487"/>
        <property type="gene ID" value="VR44_10175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5635"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="10048" checksum="84FF6847501BC93F" modified="2015-06-24" version="1" fragment="single">WHARVRAELGFGGEDPAAIEDMFDLKYRGARFSLGYGACPDLEDRAKIAALLEPERIGVHLSEEFQLHPEQSTDALVIHHPEAKYFNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMD3</accession>
    <name>A0A0F4JMD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000252">
        <property type="protein sequence ID" value="KJY34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947275.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000252.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34918">
        <property type="protein sequence ID" value="KJY34918"/>
        <property type="gene ID" value="VR44_11145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6113"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470694" evidence="2">
        <location>
            <begin position="36"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="386" mass="40324" checksum="5998A7A59C38A865" modified="2015-06-24" version="1">MESPTTSRRRLLQLGAAALPLAALGPVLPSVPARAAGAPAGLTMPAETDAHVRTYMAWPALSRVWGSGGLADVRADIAGVAYEISRFEPVVVLARPGQAADARYQCGRGARHAIDVIEIPVDDLWIRDFGPTFLAGPGAVAGVDTNFNGWGKAGTRYAQPYANDAAAAGILLGEYAVNRVRAGFTGEGGSLETDGEGTLLATVSSLVNPNRNPGMTQQQVEQELKTALGIEKVIWAPGLAGADITDCHIDCLARFTAPGKVILDRPGPDTDPKWVAVYEETKKVLRDATDARGRRLAVTELPGPDRTKITGRGTEFLSSYTNYYTPNGAVIAPRFGDAAADAAARSILQAAYPGREVVQIVIDGIASGGGGIHCATQSHPAVPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMP4</accession>
    <name>A0A0F4JMP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947002.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35637">
        <property type="protein sequence ID" value="KJY35637"/>
        <property type="gene ID" value="VR44_09690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5386"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="3">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="20464" checksum="2CC1D7FD39AE1717" modified="2015-06-24" version="1">MQTGGDTSSTSSTGSTGGTIEFVYDPTPEDYRTAFWRFNFGTWPGRGNLMTGPFVGIGLGSLLSWLRRFSENQTAFVLVAVTLAMCVIVPRVGARKAREQYQDMEEYGTCRTTVTEEGLTTTGGELSSTIEWRVFPWYFETDTLFVVMTKRTGIFFALPKRGAQDPADVDRVRAVLDRNLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMW1</accession>
    <name>A0A0F4JMW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylate--amine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000300">
        <property type="protein sequence ID" value="KJY34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947476.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000300.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34286">
        <property type="protein sequence ID" value="KJY34286"/>
        <property type="gene ID" value="VR44_12215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="36379" checksum="090CE61332682CE2" modified="2015-06-24" version="1" fragment="single">MRSVGVEEELLLVDARTGEPLALSAAVMSAASREDDGTHRPGEGTLESELKCEQVEFATRPVLRMGELAEEIVRWRAEAARHAAGAGGALAALATSPLPVRPSTMPGERYRWVSRQFGLTAREQLTCGCHVHVSVASDEEGVAVLDRIRPWLPVLTALSANSPFWQGQDSAYGSYRSRVWNRLPSAGPTDVFGSAERYHQEVRGMLATGVLRDQAMVYFDARLSARYPTVEIRVADVCLEPGTPVLLAALARALVETAARDWRAGLPPARIGVGLLRLAAWRAAKSGLDGPLLDPRSMSPAPPEAVLGLLVEHVREALEDSGDLERVREGLARLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNW1</accession>
    <name>A0A0F4JNW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000190">
        <property type="protein sequence ID" value="KJY35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35895">
        <property type="protein sequence ID" value="KJY35895"/>
        <property type="gene ID" value="VR44_08925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4956"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13273" checksum="9B02A8D0D0A09ADC" modified="2015-06-24" version="1" fragment="single">RTLIDRFGIKTPSPATPAGALSGGNLQKLLVGRELAHEAPLLLVEQPTRGVDIGAVRHIHDQLIAYRDAGHAVLLVSAELSEIRALSDRVLVMYEGRISASYTREEADERTLGLALAGAEARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPC8</accession>
    <name>A0A0F4JPC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000205">
        <property type="protein sequence ID" value="KJY35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35699">
        <property type="protein sequence ID" value="KJY35699"/>
        <property type="gene ID" value="VR44_09430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5215"/>
    <dbReference type="eggNOG" id="ENOG5033RTE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="21070" checksum="D4BDB24F8B34E29C" modified="2015-06-24" version="1">MPATHGADEDIDWQAAEAAWGTRFPSDFVAFMGRFGAGSINGEAGILLPLPKPGLQWDPAEMAEETANARQAWEAGGGRAAFDVDPESIIAWGVTAGADILCWLTTDPDPDRWPVLVVGRHTAEAFAVYPYGMAEFLLRMCSDEFDVSPVGITFWDAGHLSFVHWRKAQRRWQEGRNPETGEPDPYAGEFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPV9</accession>
    <name>A0A0F4JPV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946872.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35884">
        <property type="protein sequence ID" value="KJY35884"/>
        <property type="gene ID" value="VR44_08970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4966"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7022" checksum="60DEC1C0B70A3922" modified="2015-06-24" version="1">MPDDPAGDTIRQLADVVASNTLPEHVVELLRVALSQAETAKAAGHDDEALTIAGQALQTAENRTGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPW7</accession>
    <name>A0A0F4JPW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946733.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36235">
        <property type="protein sequence ID" value="KJY36235"/>
        <property type="gene ID" value="VR44_08245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4547"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14681" checksum="0AE702A45FAD2B91" modified="2015-06-24" version="1">MISGAQDMSNAVRSYNINFDSDDRGTLPGQVEMLALADIIGDAAVRVRIAGPKIVADAAYGVLDKCTDAMSDLAEYVSLTQSSFIPVDHPDIPLTIITDRPIVRHAEVQASLGAATNALVAFLDVARDHLDDWNGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ49</accession>
    <name>A0A0F4JQ49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000245">
        <property type="protein sequence ID" value="KJY35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947231.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene452"/>
    <dbReference type="EnsemblBacteria" id="KJY35051">
        <property type="protein sequence ID" value="KJY35051"/>
        <property type="gene ID" value="VR44_10915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6063"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="2">
        <location>
            <begin position="226"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="377" mass="38542" checksum="092BA32A070086CF" modified="2015-06-24" version="1">MLDESLLDAPDDLARADRRGLLRGAAEAGARVRTAARHATEAGLADLRPDGRPRAVLIAGPGTAATGVADLLGALAGGSAPVTRLHPTGVAHAAGALRWTLPGWAGPVDLLLIATTDGTEPGLGVLAEQAYRRGCTVVAVAPERSPLSETVDGAHGLLVPMAKAPYQEYDESAAAGPGALWALLTPLLVLLDKVGLIAAAPDALQRVADRLDRTAERCGPAIATYSNPAKTLAAELADSLPLIWSEGAGAGPAGRRFAATLAELAGRPALAADLPEALPAHGVLLSGAFAAGADPDDFFRDRVEEPQALRARVVLLRDRPTGGLTAAPAARELALSHDTAVSELEPEEGGELEQLAELLAVTDFATAYLALAGRGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR65</accession>
    <name>A0A0F4JR65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylglycinamide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000134">
        <property type="protein sequence ID" value="KJY36857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36857">
        <property type="protein sequence ID" value="KJY36857"/>
        <property type="gene ID" value="VR44_07110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="2">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="1">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24333" checksum="D531E5F328DBE952" modified="2015-06-24" version="1" fragment="single">MSLDTVKNATETPDASQPWKELGLKEDEYARIREILGRRPTGAELAMYSVMWSEHCSYKSSKVHLKQFGEKAPENDAMLVGIGENAGVVDVGQGYAVTFKVESHNHPSYIEPYQGAATGVGGIVRDILAMGARPVAVVDPLRFGAADHPDTKRVLPGVVAGIGGYGNCLGLPNIGGEVVFDACYQGNPLVNAGCIGVMKHEDIHLAKASGPGNKVILYGARTGGDGIGGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR70</accession>
    <name>A0A0F4JR70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000133">
        <property type="protein sequence ID" value="KJY36862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36862">
        <property type="protein sequence ID" value="KJY36862"/>
        <property type="gene ID" value="VR44_07055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="12738" checksum="70D2B1A08F5CCDB1" modified="2015-06-24" version="1" fragment="single">QFIPSTWAAWGQDGNGDGRRDPNNVHDAALAAGRYLCAGNRDLRTGDGLDRAVLSYNQSAEYLRTVRSWYAYYLQGAHEVPDGSGAPLPAPGTPKPSPKPTPSPTPTPTPSQTPGPKPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRX7</accession>
    <name>A0A0F4JRX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946635.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36589">
        <property type="protein sequence ID" value="KJY36589"/>
        <property type="gene ID" value="VR44_07715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4155"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471298" evidence="2">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="379" mass="40235" checksum="F633E75B04F501D0" modified="2015-06-24" version="1">MRFKRTLTATAATASLLTLATACEDPAKASPPTASPAASPAATGGASAQASPSAAGAAPATLTEAQAYVQKYTSCENLSTGPADRVNLAGYAPVGAWSVTDRGICSDPKEQDEIVISMVSDMKIHQQAYKDHITKRLDEGYWDAGLYDPVFYTKTFTVSAQKTGTALALAKSDLRVLVCNPDFSVPEGYKKEKALVDGCVLTDFVNSRDGKGSPVKGPALPSAGSIEELRRLVSPKTVDCTEMLVTNEHIASIDYQPVVGRDVRGAGVKQRAVCGKLGGPRPVDMNWLDLVSDMKTLQTVSKESQLAEVGQQRSLTQSKLMVGKDVAVESNNPTVRKGLYKLGFLRLDCEPGFSAPAGSRIQKAQVDGCVLTDFERPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT05</accession>
    <name>A0A0F4JT05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xylA</name>
        <name evidence="15" type="ORF">VR44_06930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JZWV01000129">
        <property type="protein sequence ID" value="KJY36903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946493.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000129.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000008_gene2776"/>
    <dbReference type="EnsemblBacteria" id="KJY36903">
        <property type="protein sequence ID" value="KJY36903"/>
        <property type="gene ID" value="VR44_06930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3471"/>
    <dbReference type="eggNOG" id="COG2115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="44"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY36903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="42668" checksum="FB743F5A64A03D7C" modified="2015-06-24" version="1">MTSDPLAPTPAHRFTFGLWTVGWQGRDPFGDATRPALDPVESVHRLAALGAYGVTFHDDDLIPFASGDAAREQAVKRFRTALDTAGLKVPMATTNLFTHPVFKDGAFTANDRGVRRYALRKTIRNIDLAVELGASVYVAWGGREGAESGAAKDVRTALDRLKEAFDLLGEYVEEQGYDLRFAIEPKPNEPRGDILLPTIGHALAFIDALERPERVGLNPEVGHEQMAGLNFPHGIAQALWHGKLFHIDLNGQSGIKYDQDLRFGAGDLRQAFWLVDLLESAGYEGPRHFDFKPPRTEDGEGVWASAAACMRNYLLLAQRARAFRSDPEVQAALAASRLPELALPTAEDGLAGLLADRSAFEGFDVDAAARRGMAFEQLDQLALEHLLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTI4</accession>
    <name>A0A0F4JTI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_05350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946189.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7127"/>
    <dbReference type="EnsemblBacteria" id="KJY37677">
        <property type="protein sequence ID" value="KJY37677"/>
        <property type="gene ID" value="VR44_05350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1706"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="164"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="702" mass="78424" checksum="62C13A856DA024DC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV09</accession>
    <name>A0A0F4JV09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000083">
        <property type="protein sequence ID" value="KJY37985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946038.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37985">
        <property type="protein sequence ID" value="KJY37985"/>
        <property type="gene ID" value="VR44_04510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="11864" checksum="E4006E3D90FFB128" modified="2015-06-24" version="1">MSGNNDGHTRVRYESVQQMADRIRVVSRNILKDLEEMESAVKVVTDTWDGEAHTQYLDLQKKYHARADHMQKKLEEAARLIEHGKGAYRATDVKASQLFTEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVL3</accession>
    <name>A0A0F4JVL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946089.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37889">
        <property type="protein sequence ID" value="KJY37889"/>
        <property type="gene ID" value="VR44_04775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1035"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="8136" checksum="7A0577DB5800EAFC" modified="2015-06-24" version="1">MSTNPFDDGDGRFHVLVNDEDQHSLWPVFAEVPAGWRVVFGEADRAACLEYVERNWTDLRPRSLREAMAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVL8</accession>
    <name>A0A0F4JVL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_04915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946117.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37793">
        <property type="protein sequence ID" value="KJY37793"/>
        <property type="gene ID" value="VR44_04915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1069"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046214">
        <property type="entry name" value="DUF6247"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19760">
        <property type="entry name" value="DUF6247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12443" checksum="C02ED6E59D994F58" modified="2015-06-24" version="1">MTTAPRPSGIPPMPERNPKALRAAIAEHTPALLPDFDAHWKWAIADTYDLAPVPAFMAQWWTEFALARDPRLARTVHDLEARAADAATATEAKQLLTQAAHLRREAGKAEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVR5</accession>
    <name>A0A0F4JVR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000122">
        <property type="protein sequence ID" value="KJY37061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37061">
        <property type="protein sequence ID" value="KJY37061"/>
        <property type="gene ID" value="VR44_06645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3247"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="317" mass="33926" checksum="B0E19CF4B79006C6" modified="2015-06-24" version="1">MLRIHFTGADLARTSVASRPDPLWETVLSLRMLQHRTGNPAADAWGRAVLARRPEGLRTLLPLVRPFGYFPDFLTPSDGSPDIEHGLDALAATPARHLRGDLAVLAAGGPLPAWTEDLAAGRPEALRGLAGALRGYHAAAVAPLEQTMRTTVRAEYAAQAKAAAESGIEGVLSGLGPGMRWRPPVLEVQYPVDQELHLNGRGLLLVPTLFRARTPVSLLDPELPPVLTYPARRTVSPDGSADRKLVPLIGRTRTEILHHTSEASRSTSELARLVGMSQASVSHHTAVLRAAGLISSARHRNSVLHTATSLGSLLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWD3</accession>
    <name>A0A0F4JWD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_04390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000080">
        <property type="protein sequence ID" value="KJY38048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946024.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4248"/>
    <dbReference type="EnsemblBacteria" id="KJY38048">
        <property type="protein sequence ID" value="KJY38048"/>
        <property type="gene ID" value="VR44_04390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.447"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="340"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="712" mass="75758" checksum="32B6490E8B2713FC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWE8</accession>
    <name>A0A0F4JWE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">acnA</name>
        <name evidence="14" type="ORF">VR44_04295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946007.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4228"/>
    <dbReference type="EnsemblBacteria" id="KJY38063">
        <property type="protein sequence ID" value="KJY38063"/>
        <property type="gene ID" value="VR44_04295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.426"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="702"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="904" mass="97211" checksum="3E92118522B8D349" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWL4</accession>
    <name>A0A0F4JWL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000107">
        <property type="protein sequence ID" value="KJY37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946283.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37376">
        <property type="protein sequence ID" value="KJY37376"/>
        <property type="gene ID" value="VR44_05790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1973"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="363" mass="37558" checksum="C407220E552A529C" modified="2015-06-24" version="1">MSSAPNGLHPYPIVQAPMAGGVSGPPLVAAVCEAGGLGFLAGGYKTADGMYQEIKQTRGLTRRPFGVNLFLPQTGHVDPAAVEAYRGQLAGEASWYEVSLAEEDIIGTNDDGYDAKLAILLEDPVRVVSFTFGCPDPAALARLRAVGTYTIVTVTSAEEARTAQAAGADAVCVQGVEAGGHQGTHRDDPQTDGTAAVGLLALVTQVREAVALPIIAAGGVMRGAQIAALLVAGADAAQLGTAFLACRESGAHPLHKKALTDPMFPHTELTRAFSGRPARGLVNRFVREHGPYAPAGYPQIHHMTSGLRKAAAAAGDPQGMALWAGQGHRLARALPAGELVEVLAAELAEAQSALKVLQMRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWQ1</accession>
    <name>A0A0F4JWQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945821.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38560">
        <property type="protein sequence ID" value="KJY38560"/>
        <property type="gene ID" value="VR44_03240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7864"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="174" mass="18564" checksum="912B984966FEC816" modified="2015-06-24" version="1">MGCGGFRWGLVGHLLRPVGTVALITWLYYLAPLDHGFGVLAVVALVGGLLLFGWLVLWQVGAIARSVHPRLQALEAVATAVPLFLTLFASTYFLLAQDRPAAFSEPLTRTDTLYFVVTVFATVGFGDITPVDGTARVLTTLQMVADLIMVGLVAKVLLGAVQTGLSRQPERSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXV6</accession>
    <name>A0A0F4JXV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_03285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945828.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38568">
        <property type="protein sequence ID" value="KJY38568"/>
        <property type="gene ID" value="VR44_03285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7873"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="32569" checksum="9F102200BABB192C" modified="2015-06-24" version="1">MPNGQHGQPSPEQPPAGGQWYPPEWPARIRALAEGTLTPAEPRRAATVMLLRDTPAGPAVHMLRRRASMAFAGGAYAYPGGGVDPRDEDRRIGWAGPDQEAWAARLGTDAATAQAIVCGAVRETFEEAGVLLAGKTPDTVVGDTTGDDWEADREALVGRELSFAEFLDRRGLLLRSDLLGAWARWITPEFEPRRYDTWFFVAALPEGQRTRNASTEADRTVWIRPQDAAAGYDAGELLMMPPTISTLRSLEPYGAAADALAASGAQDLTPVLAEATLEDGVVVLSWPGHDEFTKRVTLGGGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXW6</accession>
    <name>A0A0F4JXW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ORF">VR44_03340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945837.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6608"/>
    <dbReference type="EnsemblBacteria" id="KJY38578">
        <property type="protein sequence ID" value="KJY38578"/>
        <property type="gene ID" value="VR44_03340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7885"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="90"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="532"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="388"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="651" mass="70764" checksum="9EA76BCFFF5C775A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYW0</accession>
    <name>A0A0F4JYW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945565.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39335">
        <property type="protein sequence ID" value="KJY39335"/>
        <property type="gene ID" value="VR44_01925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5789"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="229"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="39081" checksum="683489EE0D197F7F" modified="2015-06-24" version="1">MSATTVLGLDAATVVDLVRERGFGPFTGVPCSYLGPVISCLQDRCPQEYLIAANEGEAVAVAAGARLAGRTPVVILQNSGLGNAVNPLTSLCHTLRLPVLLFVTWRGRPGSPDEPQHELMGEITPQMLTAMRIRNEILPDEPAALAARLDEAKAHMEATGLPFAFVVPKGAVAPYAAGPPPHERGDLMPRAEAIGRVVQSMDRASCLVATTGKTARELERDWDRGRNLYVVGSMGCASSVALGVALYARDRKVVVLDGDGAALMRLEAMAAIGRLAPPNLLHVLLDNEAYESTGGQPTASAAIDFGAIARACGYRATHDVTKAVELTAAVAAAQGAGGPQLIRVRIASGSDPRLGRPALSPPASATRFMEAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZR2</accession>
    <name>A0A0F4JZR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945559.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39329">
        <property type="protein sequence ID" value="KJY39329"/>
        <property type="gene ID" value="VR44_01885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5781"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="223" mass="23996" checksum="0BFBD80F900BB247" modified="2015-06-24" version="1">MMYEHVKRLSGPVLRAAVRLEAAGLENVPRSNGAILASNHLSIVDSTFLPLVLDRQVTFMAKSEYFAGGPWPMRIISSFMQGSGQVPVDRENQRAAVASLDACLRVVKDGGVFCIYPEGTRSPDGRLYRAKTGVAWLALTSGAPVVPVAMSGTDRVLPPRRAIPRPAKVKVTFGRPVDLSAYEGSAGDARARRAVSDLITRSIAEVSGQEYVPVYAAKVKEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K085</accession>
    <name>A0A0F4K085_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945504.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39514">
        <property type="protein sequence ID" value="KJY39514"/>
        <property type="gene ID" value="VR44_01585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4750"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471006" evidence="2">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="16857" checksum="E941F50EA8F01F4D" modified="2015-06-24" version="1">MLRPILRAAAVTALTATLAALTVSCGSGGDGDGGHRPKAAAAALAASASDPGPPPAPSPQPEKVRDAFAGLQATLDDSCTPANCAFLLGRVHDELHRMDRAMKADPKGPGHFPEPIALIARLDGELGTDHGVENLKRHQPALFGARDEISTWMQDHPDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0N3</accession>
    <name>A0A0F4K0N3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="6" type="ORF">VR44_00345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812335.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1037"/>
    <dbReference type="EnsemblBacteria" id="KJY39945">
        <property type="protein sequence ID" value="KJY39945"/>
        <property type="gene ID" value="VR44_00345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.67"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14350" checksum="75E05EA415B9D3C5" modified="2015-06-24" version="1">MTMTDPIADMLTRLRNANSAYHDSVVMPHSKIKSHIAEILKQEGFITGWKVEDAEVGKNLVLELKFGPNRERSIAGIKRISKPGLRVYAKSTNLPKVLGGLGVAIISTSHGLLTGQQAQKKGVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0U2</accession>
    <name>A0A0F4K0U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945451.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39543">
        <property type="protein sequence ID" value="KJY39543"/>
        <property type="gene ID" value="VR44_01265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2970"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="41"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="25661" checksum="C0D12CE21DABD7C7" modified="2015-06-24" version="1">MREILGRRLQRLRDRLKFPRAASRPVSEAGAGVAPSLLDAALTCAAVRHWPVLPGVGRAGADSRRCACPDPDCVVPGAHPFDPGLLAATTDARMVAWWWGRRPTAPVLLATGGAAPCAVSLPAKAAARAVVRLDAQGMRLGPIVATPTRWSLLVAPYSLERLGELLYAKDHVPSSLRFHGEGGYLLLPPSPASGGGQVRWEREPEPRWGGSEELWLPEVEAVVHALVEASSSAPGGGSRLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1A1</accession>
    <name>A0A0F4K1A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_00720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000011">
        <property type="protein sequence ID" value="KJY39698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945352.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4800"/>
    <dbReference type="EnsemblBacteria" id="KJY39698">
        <property type="protein sequence ID" value="KJY39698"/>
        <property type="gene ID" value="VR44_00720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2849"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="474" mass="50501" checksum="CF3FF019E92163FD" modified="2015-06-24" version="1">MSVVTNTTTIGAIEAPSRRNTELLLLAFAVVIPIFAYANVGLSIHGELPPGMLVYGLGFAVLAGIAHLVVRRFAKYADPLLLPIATLLNGLGVVLIWRLDQSERLRTLAKRSFGVFTESAPRQMMYTGLAIALFSVVLLVLKDHRVLQRFTYISMAGALVLLILPVIPGLGADVFGAKIWISVGGFSIQPGEFAKIVIAIFFAGYLMVKRDALALASRRFMGLYLPRGRDLGPILMIWAMSLLVLVFENDLGTSLLFFGMFVIMLYVATERTSWIVIGLLMSVGGATVVGMTASHVKVRVTAWLDPFACYSTSGACEQVGQSIMSFGSGGVLGTGWGQGNSDLIGFAANSDFIFSTVGEELGLTGVMAFLLLYGLIIERGVRTALAARDPFGKLFAIGLSGAFALQIFVVAGGVMGLIPLTGMTMPFLASGGSSVLANWVLIAILIRISDTARRPAPAPAPSPDSEMTQVVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K289</accession>
    <name>A0A0F4K289_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_00050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945254.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40058">
        <property type="protein sequence ID" value="KJY40058"/>
        <property type="gene ID" value="VR44_00050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.10"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY40058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="14107" checksum="0A0C87CC6E43C93D" modified="2015-06-24" version="1">MKTILNVIWLILSGIWLFLGYCLAGLILCVTIIGIPFGIAAFRIAVYALWPFGYTTVERRDAGAGSFIGNILWLLLAGWWLALGHIATGIALCVTIIGIPFGIANFKMVPLSLFPLGREIVPTDAPFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K404</accession>
    <name>A0A0F4K404_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_00155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945271.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene997"/>
    <dbReference type="EnsemblBacteria" id="KJY39911">
        <property type="protein sequence ID" value="KJY39911"/>
        <property type="gene ID" value="VR44_00155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.29"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="37276" checksum="CA8CBC1598778E06" modified="2015-06-24" version="1">MEHVRDLTLLPKAHLHLHFTGSMRPSTLLELADKYGVRLPDALTAGEPPKLRATDERGWFRFQRLYDAARSCLREPEDIRRLVREAAEEDVRDGSGWLEIQVDPTSYAPLLGGMIPAVEIILDAVDAASRETGLGMRVLIAANRMKHPLDARTLARLAVRYADRGIVGFGLSNDERRGMARDFDRAFAIAREGGLLAAPHGGELTGPSSVRDCLDDLHAARIGHGVRAAEDPRLLKRLADRQITCEVCPASNVALGVYERPEDVPLRTLFEAGVPMALGADDPLLFGSRLAAQYEIARRHHAFTDAELAELARQSVRGSAAPEEVKAKLLDGIEHWLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5D5</accession>
    <name>A0A0F4I5D5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_40250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001707">
        <property type="protein sequence ID" value="KJY16899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16899">
        <property type="protein sequence ID" value="KJY16899"/>
        <property type="gene ID" value="VR44_40250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY16899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21065" checksum="75B2D757ED66FDDF" modified="2015-06-24" version="1" fragment="single">VTALTEIHRAGLIHRDLKPENVLLSQDGVRVIDLGIARAAESGVDTRLTRTGLVIGSPAFMSPEQAEGRELTPASDLFSLGSVLAMAATGVSPFAADSTLQTLFNLVQTLFNLVHGEPELSAVPAGLRPLVARCLAKAPADRPTPAELLHLLGPVPPAGRLPWPPAVHGLIAAQGAAIDRLLGVGPGPAPGRPAPRIPHPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8X9</accession>
    <name>A0A0F4I8X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_40130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001689">
        <property type="protein sequence ID" value="KJY17156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001689.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1334"/>
    <dbReference type="EnsemblBacteria" id="KJY17156">
        <property type="protein sequence ID" value="KJY17156"/>
        <property type="gene ID" value="VR44_40130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6398"/>
    <dbReference type="eggNOG" id="COG3766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY17156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="14452" checksum="A234ABE30FC2B7F8" modified="2015-06-24" version="1">MSDIVNGLGRTTAYGALGLVLLILGIVLVDVLTPGKLPKQIWEERNRNAALLLSSALLGIGGIVFTSIWTTYEDFGKGLLSTAAFGLLGLVLMAVAFLVLDLVTPGKLGAIVVDPEPHPAVWVTACCNLAVAAIVAASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHK9</accession>
    <name>A0A0F4IHK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001478">
        <property type="protein sequence ID" value="KJY20938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952329.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001478.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20938">
        <property type="protein sequence ID" value="KJY20938"/>
        <property type="gene ID" value="VR44_38480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5346"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="19083" checksum="886485086E39B44E" modified="2015-06-24" version="1">MSDEQRTPPELVGDERATLTSVLQWQRDTLRMKCAGLTDEQLRRKAVPPSGLSLLGLVRHLAEVERGWFRNVLGGEDVRGYFPKNEAGEWTEFHVEDADPAEAFRIWEDTCERSRKIVAAAESLDVRGHFGDQPYSLHYILAHMIEEYARHNGHADLLREAIDGVTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIB2</accession>
    <name>A0A0F4IIB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001444">
        <property type="protein sequence ID" value="KJY21732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21732">
        <property type="protein sequence ID" value="KJY21732"/>
        <property type="gene ID" value="VR44_38175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5241"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13334" checksum="5D8C311AE01498AC" modified="2015-06-24" version="1" fragment="single">IRDRSHTPAATSASAPALQATNCALGGAGGEGGKGGEGGKGGQPGQPGEPGKPGGTACLGFSDLPDKPKSELNVVDKVRIVLTVMAADDPKEMKEKIADKYKITTEQIDTWKKQYQDGDWFALMSGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJD6</accession>
    <name>A0A0F4IJD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_38225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001450">
        <property type="protein sequence ID" value="KJY21568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952282.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001450.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21568">
        <property type="protein sequence ID" value="KJY21568"/>
        <property type="gene ID" value="VR44_38225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY21568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15271" checksum="3CBB3D25571161B5" modified="2015-06-24" version="1" fragment="single">MRALVVGREALLLEVDSAGEVAALHAELLRRRDAGELGAVREVVPAARTVLLDGVREPGALAARIARWEVPPLAEAEGPLVTVPVRYDGPDLAEVARAWGVAEGEVAGLVGGIEFRVAFCGFAPGFGYLTGLPERLWLPRRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INU3</accession>
    <name>A0A0F4INU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="3" type="ORF">VR44_37680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001400">
        <property type="protein sequence ID" value="KJY23153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952179.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23153">
        <property type="protein sequence ID" value="KJY23153"/>
        <property type="gene ID" value="VR44_37680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5042"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="26673" checksum="C0209B841A73C71F" modified="2015-06-24" version="1">MCRHLAYLGPDIPLGVVLGDPEHSLVRQSWAPRRQRYGTVNADGFGVGWYAAGDPVPARYRRAGPVWGDEGFADLCRVVRSGAVLAAVRDATFAGADGEAAAAPFASGPWLFSHNGAVRGWPDAAAPLASALPVHELLELAARTDSALVWALVLHRLRQGDDPGTALAEAVRELAAAAPGSRLNLLLTDGASIAATAWGDSLWYLPAHPSGRVVVASEPYDDDTGWCEVPDRTLLTATRTRVALIPLKESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPJ3</accession>
    <name>A0A0F4IPJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001330">
        <property type="protein sequence ID" value="KJY23922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1538"/>
    <dbReference type="EnsemblBacteria" id="KJY23922">
        <property type="protein sequence ID" value="KJY23922"/>
        <property type="gene ID" value="VR44_36850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4683"/>
    <dbReference type="eggNOG" id="COG5441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="12"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="24706" checksum="B4AE30134B49F992" modified="2015-06-24" version="1" fragment="single">ALDRSRPARLGSGSRPLVAASMAGVTTTGVDAARERLTELGYEVLVFHVSGTGGRTLEKLAGQGIFAGVLDLTLSELADDLCGGILTAGPDRLSAAGRAGIPQVVSLGALDMVKFGPLETLPERARYRRVRVHNPSITVIRTTGSECAELGRRVAAKLRVATGPTAVCVPLRGLSTLGAPGGPYHDPDADGALFSALREGLRGSAARLYDYDTHINDPAFGRAAADRLHAMIGAVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPL0</accession>
    <name>A0A0F4IPL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001322">
        <property type="protein sequence ID" value="KJY23960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23960">
        <property type="protein sequence ID" value="KJY23960"/>
        <property type="gene ID" value="VR44_36750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="11597" checksum="33D2A877910CF2FD" modified="2015-06-24" version="1">MDGGQRGGGRLSFGGLAGGVRQLGLFEGVQGPGVRLLREVRGVEAGVPGDGHGDGWAGGDDVAQLRVLPAGAGRDGLAQPCRQPVRGAFGAAGAGGEGGEVLGADRRGGPDDGGAEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQD0</accession>
    <name>A0A0F4IQD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_36980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001340">
        <property type="protein sequence ID" value="KJY23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952051.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001340.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7421"/>
    <dbReference type="EnsemblBacteria" id="KJY23879">
        <property type="protein sequence ID" value="KJY23879"/>
        <property type="gene ID" value="VR44_36980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4780"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="15808" checksum="F27EBB9F0FA0A050" modified="2015-06-24" version="1">MPGPYVIRGAVVLPEAELAWRFSRSSGPGGQHVNTSDSRVELLFDVAATKALPAVWKERALERLAGRLVDGVLTVRASEHRSQYRNREMALVRMAAVLAEATAAPPKVRRPTKIPRGINERRLREKKARSETKRGRSSRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQG8</accession>
    <name>A0A0F4IQG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001258">
        <property type="protein sequence ID" value="KJY24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951840.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001258.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24270">
        <property type="protein sequence ID" value="KJY24270"/>
        <property type="gene ID" value="VR44_35860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4329"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="27840" checksum="AB9002AC400FFC41" modified="2015-06-24" version="1">MAALAGPVALRLYRRPGIITGRDGRLSTSTTLALAWTVILVWLLLTILGYGLTAGGGTGYFGGAHGPLSSLTTVYLPLLGGPYVALIAAKTVVGIRVENGTLAKPAPKPTATGRRPLRELIANDSGRTDLVDLQYVALSAVTMLYVVLFFLSDVSRGLPELPAEIWALTGAPAGAYLVNKMATRGNPVITHAAVTPDGTLTVEGGGFTDPRLTVDDTPLPAVQDPATGTLTATLPPGTTPPFTLVVTSRGLRSDPYHQPAAPATAQPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR94</accession>
    <name>A0A0F4IR94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001271">
        <property type="protein sequence ID" value="KJY24194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951880.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001271.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24194">
        <property type="protein sequence ID" value="KJY24194"/>
        <property type="gene ID" value="VR44_36070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24115" checksum="0F4DC67E48B6FB64" modified="2015-06-24" version="1" fragment="single">MGIADGRVVIVTGAGRGLGRAHALAFAAEGARVVVNDLGVGLDGLPGPGSPATRVVEEIRALGGEAVAHGGDVATGEGARSLVACALDAFGRLDTLVNNAGFLRDRMLVNLGEDDWDAVMRVHLKGHFLPLRAAAAWWRAEAKAGRPVAARVVNTSSGAGLLGSVGQGNYSAAKAGILGLTLVAAAEMGRYGVQVNAVAPAARTRMTEETFAATMAAPAAGAFDAMAPENVSPLVVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRX7</accession>
    <name>A0A0F4IRX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C1 regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001171">
        <property type="protein sequence ID" value="KJY24775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene860"/>
    <dbReference type="EnsemblBacteria" id="KJY24775">
        <property type="protein sequence ID" value="KJY24775"/>
        <property type="gene ID" value="VR44_34350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3848"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="155" mass="16816" checksum="88650D0C7E9B9F38" modified="2015-06-24" version="1" fragment="single">LLALREAGGWSGLGDQRACEEALTRAHTEFARGACAADPEWMSFFGEAELESLESRCWAALGEHARAARHARRAADLQDPHFARNVALYTAELADDLARAGAPDEAAWAGGRVLDLLTEVQSTRIRSMLAGTARTLVPHQRSPRVGDFLARHAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS48</accession>
    <name>A0A0F4IS48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ORF">VR44_35760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001251">
        <property type="protein sequence ID" value="KJY24308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951818.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001251.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24308">
        <property type="protein sequence ID" value="KJY24308"/>
        <property type="gene ID" value="VR44_35760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4306"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="110"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="118"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="211"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="369" mass="39128" checksum="EBEEF3B16C9766A1" modified="2015-06-24" version="1">MTSSSASSLSARPHALAAYGWDEYWAAEFAPYAAEGLLPGRVVRVDRGQCDVMTEDGVIRADTAFVTPHDPLRVICTGDWAAVEAAGNPRYVKAYLPRRTAFVRSTSSQRSEGQILAANVDHAVIAVSLAGEPDLGRIERFLALAWESGAQPLVVLTKADLVPDPDTLAYLVRDVETTAPGVQVLAVSSHTGEGTDVLAAIVSGGTSVLLGTSGAGKSTLANALLGEDVMDVQATREVDGKGRHTTTTRNLLALPGGGVLIDTPGLRGVGLFDAEAGVGQVFSEIEDHAADCRFHDCAHESEPGCAVLAAVADGSLPERRLESYRKLLRENQRIVAKTDARLRAELHRDWRLKAAQGRANYAAKRGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS85</accession>
    <name>A0A0F4IS85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_35160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001216">
        <property type="protein sequence ID" value="KJY24504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24504">
        <property type="protein sequence ID" value="KJY24504"/>
        <property type="gene ID" value="VR44_35160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4111"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="11743" checksum="C807D984165A6A2D" modified="2015-06-24" version="1">MYGHPFSDSRAPDSTGLPERAGFPFGAAHGFELPHLFTTVPLTAPQAKLAERLTGRWTRFAGAPARPRFAGRGPSVLRPAPGGGGTRAPDTPAAHHCALRDGLAAPVPEPGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISH6</accession>
    <name>A0A0F4ISH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001142">
        <property type="protein sequence ID" value="KJY24960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951467.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001142.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24960">
        <property type="protein sequence ID" value="KJY24960"/>
        <property type="gene ID" value="VR44_33840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3693"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="25785" checksum="E2740ED7D2C1F167" modified="2015-06-24" version="1">MRVEIWSDIACPWCYIGKARFTKGLAEFAHRDEVEVVYRSFELDPHGAKGVTAPVLEMLARKYGRTLEEARGMEEHVAASARAEGLDYRTDGRDHGNTFDIHRLLHLAAARGRQVELLDLAFRANFAEERSVFDPQVLLDLAVEAGLDEAEARAVLADDSAYAAEVRADEREAAELGANAVPFFVLDRRYGISGGQPAEVFTQALERAWAGRELPEPAADAEACEPDGACAVPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISP3</accession>
    <name>A0A0F4ISP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001378">
        <property type="protein sequence ID" value="KJY23731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23731">
        <property type="protein sequence ID" value="KJY23731"/>
        <property type="gene ID" value="VR44_37450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4909"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="297" mass="31456" checksum="36AB8F2EA8903599" modified="2015-06-24" version="1">MVSFQNVTKSYGQVKAVDGLTLELHPGETVALLGPNGAGKSSTLDLLLGLRPADSGTVSLFGTTPREAVTAGRVGAMLQSGGLMEEVTVRELVTLGCALHPRPYPVDEVLSRSGIEEIAGRLVNKLSGGQEQRVRFALATAGHNDLIILDEPTTGMDVTARHAFWATMREQAAQGRTVLFATHYLEEADAIADRVLVLNKGRLLADGTAAEIKAKAGARKVAFDLDGDIDQQVLRALPGLTSFQVNGTTVRLQSRDADATVHAVYALGLYPRNLEVAGLGLEQAFIALTEAEEADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT00</accession>
    <name>A0A0F4IT00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001169">
        <property type="protein sequence ID" value="KJY24784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951553.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24784">
        <property type="protein sequence ID" value="KJY24784"/>
        <property type="gene ID" value="VR44_34305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3838"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12957" checksum="7985C0673BDFAA95" modified="2015-06-24" version="1">MAEPERTERRQRPAPLLFEPSEAVADPEHFFDLESIEDPRELLARATELTLAFRAAQNRAEEFQALAAAQLADPRRFDRLTPSAIAEAAEWTEDYARRMIEFGEDLQRGASPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITG8</accession>
    <name>A0A0F4ITG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001094">
        <property type="protein sequence ID" value="KJY25307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25307">
        <property type="protein sequence ID" value="KJY25307"/>
        <property type="gene ID" value="VR44_32835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3385"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="636" mass="68924" checksum="5E04117277B211AA" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUC4</accession>
    <name>A0A0F4IUC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001049">
        <property type="protein sequence ID" value="KJY25607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25607">
        <property type="protein sequence ID" value="KJY25607"/>
        <property type="gene ID" value="VR44_32060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7180" checksum="C2FDEB3A325D5B39" modified="2015-06-24" version="1" fragment="single">MTSGLPRRFLDLLTRPRVAGAAWWSVVSRLPVYLMSLALVLTVREQGGSYAQAGLVAALYTVGMALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUF0</accession>
    <name>A0A0F4IUF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="6" type="ORF">VR44_31955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001042">
        <property type="protein sequence ID" value="KJY25640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951121.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001042.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5914"/>
    <dbReference type="EnsemblBacteria" id="KJY25640">
        <property type="protein sequence ID" value="KJY25640"/>
        <property type="gene ID" value="VR44_31955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3106"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16501" checksum="1B6CD092591512DF" modified="2015-06-24" version="1">MGSVRKASAWLGLVEDSDDERYYDDDYAEAVDGRRGSVSGPGDQWVTDPRVRVASESAVERGRRIATVTPDGFRDARGIGELFREGVPVIVNLSSMDPTDAKRVVDFAAGLTFGLRGSIERVATRVFLLTPADTQIVSGEAGGRSRDFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV48</accession>
    <name>A0A0F4IV48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001012">
        <property type="protein sequence ID" value="KJY25905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25905">
        <property type="protein sequence ID" value="KJY25905"/>
        <property type="gene ID" value="VR44_31295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="20992" checksum="02EB764A4AE553EB" modified="2015-06-24" version="1" fragment="single">MGAVRADPARRRRQAGAGALAGLAAAFAGLALGMLAAAFVRPEASPLTAAGGAVVDRTPAAVKEWAIRSFGTSDKLVLTLGIAVVLAVLAAATGILAVRRPRTGCALASAFGLLGAAAALSRPGAGWKDALPSLAAGAAATVALYLLVTVVRRPHPTAAARGTGTWPMDRRAFGRLLTATVAASAVAGYAARRLGAHGSAGATASRADLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVB8</accession>
    <name>A0A0F4IVB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001006">
        <property type="protein sequence ID" value="KJY25947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25947">
        <property type="protein sequence ID" value="KJY25947"/>
        <property type="gene ID" value="VR44_31165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2722"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="55" mass="5947" checksum="37B91E40FC46FE3E" modified="2015-06-24" version="1" fragment="single">AHLRLTDEQFAELGARLKALADEYRALSDPSLPDASLVFALFHPGSHAQAEGDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVW7</accession>
    <name>A0A0F4IVW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001025">
        <property type="protein sequence ID" value="KJY25779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951061.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25779">
        <property type="protein sequence ID" value="KJY25779"/>
        <property type="gene ID" value="VR44_31640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3036"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="43345" checksum="C01F056BEC15A4A3" modified="2015-06-24" version="1">MPIIALSADEARRIALRAQGFLGAPDRKAGVRGVLRHLGAVQLDTISVLARSHELIPYARLGAVGRDTVEKAYWSDSHAFEYWSHAACILPSEEWPHFAFRRRARRARGHRWHVLQDKERSTAAVLDRLRADGPLTSSELGGAKNGGEWFEWSETKIAVEWLLDTGEVVCTERRGWKRVYDLAERAVPDALFHDDLDDLECLRRLVELAGRSLGVGTRADIADYHRLKGEQFDAVVADSGLVPVSVEGWGKPAWAHPEALASEPRGRHRTTLLSPFDSLVWDRPRTERIFGFTHRLEAYVPKPKRIHGYFAMPLLAGGRLQGRVDPGREGRTLVARQLSLTTPKAAGAMAEALWEAARWVGCEDVRVERAADEREAAAVTAELTARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX55</accession>
    <name>A0A0F4IX55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000994">
        <property type="protein sequence ID" value="KJY26023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26023">
        <property type="protein sequence ID" value="KJY26023"/>
        <property type="gene ID" value="VR44_31035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="478" mass="49177" checksum="A0F930E2827539E7" modified="2015-06-24" version="1" fragment="single">LYYGSLVLNDEDDLFAGFNASSSTRFVTAVAIGVPGGNFPATTFGDFYDAGTQAYTCNSCSRPRWGDYSGTARDPSNPKDVWTVQQIGAIANTGIRGGDWGTAMDRVTLSPPTVTSVTPNHAPERAQCVNTVTVRGTEFPTSGTTVRFGSVDATNVNVIGPEELTAEAPPQPRGTVDVTVTTPNGTSPITNADKFTYDADTSAPTASASVSPSPNAAGWNNSSPATVDISAGDGSCGSGIQEITYSATGAQPIGTTHVSGGSAAVPITVDGVTTVTFTATDNAGNTSAPQTSTVRLDTAAPTITILRPTAGTYLFHQPVTASYACADATSGVASCVGTVPNGSPIDTSTFGSHTFTVNAADVASNPATKSVTYTVAYRICLLYDPSRPIRGGNSTVPIRLRICDVNGANLSSPGITLTPSRIVGPTTVPFTTPFRYDAQLGGYIVNVSTRGLANGSYNLQFTISGADTTTHVAPFTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXA5</accession>
    <name>A0A0F4IXA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_29535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000914">
        <property type="protein sequence ID" value="KJY26642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950677.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000914.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26642">
        <property type="protein sequence ID" value="KJY26642"/>
        <property type="gene ID" value="VR44_29535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2281"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16375" checksum="5CB50F5019B464F4" modified="2015-06-24" version="1">MDTGLLILRLLVGLLIAGHGVQKISTHLGGKGLDGGAREFRADGFRGGALTALAAGGGQIGSGLLLTAGLLTPLAATGAIGVMTVALTVKWSNGLWVQNDGYEYPLVLIGAAVALAATGPGTWSLDDALGLTPYPLWWTALVLTAGVGSGLLTRLALHRAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXV3</accession>
    <name>A0A0F4IXV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000936">
        <property type="protein sequence ID" value="KJY26469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950761.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000936.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26469">
        <property type="protein sequence ID" value="KJY26469"/>
        <property type="gene ID" value="VR44_29995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2382"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6961" checksum="A11B60AD7E88CC38" modified="2015-06-24" version="1">MGIRQGGTENWTKSSYSGGNGACVEVKSPVTEAIAVRDSKVQDGPSITFAPGSWTSFVTGVVEGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYJ2</accession>
    <name>A0A0F4IYJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000907">
        <property type="protein sequence ID" value="KJY26734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26734">
        <property type="protein sequence ID" value="KJY26734"/>
        <property type="gene ID" value="VR44_29280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="17867" checksum="F1485EE8C446E420" modified="2015-06-24" version="1" fragment="single">MAFFRSRDRRDNTQRADDLLAGARALYEAGRHAEAEAEARSVAAAVGRHPDDLAVPMAVSIAALAASAQGRHEEALAETKSAGVLDRAFTRAERAQETGLVDLNEAMALFSPRPWPSSGWTVPPRPVRGLRPATRSAWRPSGRTIPARFRPARCSTASTAPDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ81</accession>
    <name>A0A0F4IZ81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_27825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="JZWV01000846">
        <property type="protein sequence ID" value="KJY27340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950367.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000846.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27340">
        <property type="protein sequence ID" value="KJY27340"/>
        <property type="gene ID" value="VR44_27825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY27340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="17718" checksum="004553F927714486" modified="2015-06-24" version="1" fragment="single">MASVIVIGGGISGLAAAWQLRGEAEVTVLEGGARVGGKLRTGTFAGVPVDEGAESLMALRPEAVTLARETGLGGALCDPAASPTALWTGGELRPLPAGHVMGVPGDPAALAGTGLLSPEGAARAAREAELPAVPLAGDCSVAAYLTARFGREAVDRLVEPLLGGVYAGRADRLSLRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZM6</accession>
    <name>A0A0F4IZM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_27435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042820167.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000831.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5368"/>
    <dbReference type="EnsemblBacteria" id="KJY27457">
        <property type="protein sequence ID" value="KJY27457"/>
        <property type="gene ID" value="VR44_27435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1655"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11324" checksum="654DD41F51253976" modified="2015-06-24" version="1">MTYVKACALSELEENTPKRVELDGTPVSIVSTEGEVFAINDICSHANVSLSEGEVEDCMIECWLHGSAFDLRTGKPSGLPATRPVPVYPVKIEGDDVLVSLTQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZN3</accession>
    <name>A0A0F4IZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000830">
        <property type="protein sequence ID" value="KJY27475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950296.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000830.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5366"/>
    <dbReference type="EnsemblBacteria" id="KJY27475">
        <property type="protein sequence ID" value="KJY27475"/>
        <property type="gene ID" value="VR44_27425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1652"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="471" mass="52307" checksum="07716B42475F2269" modified="2015-06-24" version="1">MTTETAHPELEGLGNYEYGWADSDAAGAAAKRGLSEDVVRDISAKKSEPEWMLNLRLKGLKLFDKKPMPKWGSDLSGIDFDNIKYFVRSTEKQAESWEDLPEDIKNTYDKLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEQQGVIFLDTDTALKEHPELFQEYFGTVIPVGDNKFASLNTAVWSGGSFIYVPKGVHVDIPLQAYFRINTENMGQFERTLIIVDEDAYVHYVEGCTAPIYSSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAVAYEGATMEWIDGNIGSKVTMKYPAVYLMGEHAKGETLSIAFAGEGQHQDAGSKMVHMAPNTSSNIVSKSVARGGGRTSYRGLVEIGEGASGSKSNVLCDALLVDTISRSDTYPYVDVREDDVTMGHEATVSKVSDDQLFYLMQRGLTEFEAMAMIVRGFVEPIAKELPMEYALELNRLIELQMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J025</accession>
    <name>A0A0F4J025_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
            <ecNumber evidence="2">4.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphatidylinositol diacylglycerol-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylinositol-specific phospholipase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_28050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:17093"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58484"/>
            <dbReference type="EC" id="4.6.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000855">
        <property type="protein sequence ID" value="KJY27249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27249">
        <property type="protein sequence ID" value="KJY27249"/>
        <property type="gene ID" value="VR44_28050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1823"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004436">
        <property type="term" value="F:phosphatidylinositol diacylglycerol-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469993" description="1-phosphatidylinositol phosphodiesterase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PLCXc" evidence="7">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="299" mass="32164" checksum="0A97F4DFD3CDDFE0" modified="2015-06-24" version="1">MTGALTAAAGATALGLGAAAPASARGLTVRTPATRTPATRTLGPQDWMAALPDSTALQRMTIPGTHDSGARLGGLYVACQNTSIAEQLDSGIRFLDVRCRVTGGSFAIHHAAFFQNLMFGDVLVACAAFLAAHPSETVLMRVKQEYSTESDATFRAVFDDYLDHRGWRPLFRIADTLPTLGQARGRVVLLADNAGLPGLRYGDGGVFDIQDDYNTEPFAKRGRIEDQFRKAVQQPGKLFVNYTSTAAYMPPRWNSDRLNPQVHAFVDGAELAGRTGLGIVPMDFPNTRSGLVASLIRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J130</accession>
    <name>A0A0F4J130_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000817">
        <property type="protein sequence ID" value="KJY27584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950258.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000817.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27584">
        <property type="protein sequence ID" value="KJY27584"/>
        <property type="gene ID" value="VR44_27225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1581"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046039">
        <property type="entry name" value="DUF5997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19460">
        <property type="entry name" value="DUF5997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14835" checksum="DB8FB1859023C6AB" modified="2015-06-24" version="1">MTSHQSTQTMKPATAAKKLGVYLEATPAEFREGVVSRTELNALQAEPPAWLVELRRNGPHPRPVVASKLGVSIAGLARGGITEALTTEQIEALKQDNPEWLQKERATQAEVRKEAVRIKEKQAQKAQKDEQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1C4</accession>
    <name>A0A0F4J1C4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="7" type="ORF">VR44_27080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000808">
        <property type="protein sequence ID" value="KJY27669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950232.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000808.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6921"/>
    <dbReference type="EnsemblBacteria" id="KJY27669">
        <property type="protein sequence ID" value="KJY27669"/>
        <property type="gene ID" value="VR44_27080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1578"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="6">
        <location>
            <begin position="31"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24247" checksum="B6A189D77C6F67C3" modified="2015-06-24" version="1">MHLDHDVTYPHRHTHSAAPLRTDGTRRALRIGLGGPVGSGKTATVAALCRALRADLSMAVVTNDIYTREDAEFLLREAVLPPERISAVETGACPHTAIRDDISANLEAVEELEETVGPLDLILVESGGDNLTATFSRGLVDAQIFVIDVAGGDDIPRKGGPGVTTADLLVVNKTDLAPYVGSDLERMARDAAEQRGDLPVAFQSLRGAEGVAPVAGWVRERLAAWAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1D0</accession>
    <name>A0A0F4J1D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000766">
        <property type="protein sequence ID" value="KJY28072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950058.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000766.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28072">
        <property type="protein sequence ID" value="KJY28072"/>
        <property type="gene ID" value="VR44_26160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1388"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="27067" checksum="B4AB1C6160541530" modified="2015-06-24" version="1">MRIDLASAPGSAERPNEDWVSASTPAAGGGVVVVLDGVTPPRGDDGCAHGVPWFATRLGGRLTELSGSRRDMPLDRILARAIGDTADAHRDTCDLSHVRTPQATVVMVRWDEARVEHLVLSDSVLLLQAPGGAVTAVLDDRLDRIPHVVRGSVAATDALRNAEGGFFTAAADPSVAARAVVGRTPRREVGALAALTDGASRWTDTFGQGDWAACLGVLREEGARGLIGRVRAIESDPGRPPARHKRHDDASAVYAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1I3</accession>
    <name>A0A0F4J1I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_25985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000758">
        <property type="protein sequence ID" value="KJY28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950024.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000758.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28145">
        <property type="protein sequence ID" value="KJY28145"/>
        <property type="gene ID" value="VR44_25985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1300"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25320" checksum="3B286CE133515B50" modified="2015-06-24" version="1">MSLEVRLEGLSVGYGAGAPVLEPTDLVFPAGSFTALLGPSGCGKSTVLGAVAGFVRPTAGRVTSGSVPVREPGPERGVVFQHYALFPWRTALGNVEFALKRLGLSRPERRERALAALEEVGLADGARKYPAQLSGGMQQRVALARALAAEPEVLLMDEPFGALDALTRSRMQELLRELWRRRGTTVLFVTHDIDEALALAGRVVVLGGTPGRVLADHPVPPGPPDPSLRALIATHLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2E5</accession>
    <name>A0A0F4J2E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000769">
        <property type="protein sequence ID" value="KJY28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950072.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000769.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28034">
        <property type="protein sequence ID" value="KJY28034"/>
        <property type="gene ID" value="VR44_26230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1406"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17007" checksum="95496559B73D7D09" modified="2015-06-24" version="1">METVRFAALVAATLTVGLVSGLFYGFSVAVMPGLRASADRTVVETMQRINVAILNGWFLLGYVGALVFTGLALALRLVVGGGGGTAPLAGAFVAYVLVVLVTARVNIPLNNALAQAGPVERIADPAAVRRAFEGPWVRANTGRTVLCTVAFGLLVWALVLDGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J305</accession>
    <name>A0A0F4J305_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949835.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000714.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28615">
        <property type="protein sequence ID" value="KJY28615"/>
        <property type="gene ID" value="VR44_24985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1085"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12229" checksum="47217A2714CB43A0" modified="2015-06-24" version="1">MATIQECRAALDRLSDNLAGADGGVRGAAALDRSLSCHITDLDVTFAGRLEGGRIRVDALTPGPPRAKAEIRLAMSGDDLLALVDGELKFAKAWASGRVRLEAGFRDLLRLKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J326</accession>
    <name>A0A0F4J326_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPP family protein+B94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950037.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000764.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28098">
        <property type="protein sequence ID" value="KJY28098"/>
        <property type="gene ID" value="VR44_26060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1367"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="17515" checksum="8E9D88D81BCFC876" modified="2015-06-24" version="1">MPSATTPAPTAPAAPVPAPGAPPRPSAVAAFHSVSAATTVLLALVAIGAAIHEPVLIPPLAASAALVHSAPTLPLAQPRGVVVGHLIGAACGYAVLAAAGSSAWAAALAAGLTLALLTLARTPHSPAVATAVVTVLQSPAPARFVPLLFGSTVLLVLTGYAGSRIRRTAPRYPAYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3N0</accession>
    <name>A0A0F4J3N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000692">
        <property type="protein sequence ID" value="KJY28937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949675.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000692.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5554"/>
    <dbReference type="EnsemblBacteria" id="KJY28937">
        <property type="protein sequence ID" value="KJY28937"/>
        <property type="gene ID" value="VR44_24105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.815"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="44366" checksum="8C5B7127961E4349" modified="2015-06-24" version="1">MQVIQSTKLANVCYEIRGPVLEEAMRLEAAGHRILKLNTGNPAAFGFDCPPEILEDMLRNLGHAHGYGDAKGLLSARRAVMQHYQTKGIELDVEDVYLGNGVSELIQMSMQALLDDGDEVLVPAPDYPLWTASVSLAGGTAVHYRCDEQSDWMPDLADIERKITDRTKALVIINPNNPTGAVYDDEMLRGLTDIARRHNLIVCSDEIYDRILYDGATHTNTATIAPDLLVLTFNGLSKNYRVAGYRAGWMAVCGPKKHAASYIEGLTILANMRLCANMPAQHAVATALGGRQSIVDLVLPGGRLLEQRDTAYDLLTQIPGVTCVKPKGALYLFPKLDPSVYKIKDDRQMVLDLLRAEKIMVVHGTGFNWPEPDHFRIVTLPNAKDLADAVTRIGSFLDGYGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Y3</accession>
    <name>A0A0F4J5Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000618">
        <property type="protein sequence ID" value="KJY29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949311.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000618.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29772">
        <property type="protein sequence ID" value="KJY29772"/>
        <property type="gene ID" value="VR44_22110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.304"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="29424" checksum="CE7DE30F87892953" modified="2015-06-24" version="1">MADTVNSLAARVHELLLALVTQGVDARVPGQGSSSSSAYGFLGAPGRVDVASGLQDVVVRAGALGPGGTWLAAAGHAGLGVLAVLRGRAEQAIPHLDAAVSAGYNDCVGLHAAPIRPLHGDPRFRALYQRMRITQADLDELLWLHQEMQLTAQEAQRAMVDNIGRLDTGVSLLAQAPMPTREPDTAGVLITRIDLAVTQSAFRQAALQMDFQRSSGNTSLGLIDDTWDHAQAMRDAWHAEDQDSRRQRFAEGRAFVARPGAGTVLGPCPPLGSITYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J612</accession>
    <name>A0A0F4J612_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gala protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000628">
        <property type="protein sequence ID" value="KJY29630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949372.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000628.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29630">
        <property type="protein sequence ID" value="KJY29630"/>
        <property type="gene ID" value="VR44_22440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.377"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="39419" checksum="EFA05A6C821F2287" modified="2015-06-24" version="1">MTRPTPVRCPAIEHPDLPLADPAGLDPLLARLAQDHPVETDETFPLGTLRADGRVDLCKQGLGPAGAARLLPATTASRHAAHLLLGTNSIADEGARTLAAALTAAGPEHGLHTLYLGCNRIGPDGLLALAGALADDTAVRALWLKRNPLHEDGARTLAALLRRNTALRTLDLVNTGITTDGVRLLLDALRTRETPLERIYLGGNGLTAEAAPLLAALIGEAGVRELYVPANHLGDEGAAVLAAAAAGAGPDRPVRLGLGGNGIGVPGARALAAALGGIESLDLGRVMSERSLGSTGNATGDEGAYALAEALPGSPLRRLELRHTGITGRGAKRLLAALPDGSPLEHVGLGPGTPRRLKRSFAERLRPAAPGHLDVRAIGSVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6B2</accession>
    <name>A0A0F4J6B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949318.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29740">
        <property type="protein sequence ID" value="KJY29740"/>
        <property type="gene ID" value="VR44_22155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.315"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="295" mass="31695" checksum="17C5EE1AF29B84C8" modified="2015-06-24" version="1">MGMTVLYIAFAFVALWLLAEVLMQYKARLRWRLLAFAGFLGVVAGVILPSVLVIAVGATAFAVGQTLVTLSFRKGFVAGWALRKGKGGEPARQEAQSRRRRSGRGAPRPEPALEVTGLEYGSQDPAAPRAAGAEDDDRDDRDVFTPQPVPEETGSYGIQSFAPQQPDATAAFASPFAADGQDGGQHAAYYDPGQGQGGYDYTGGYPAGGQQVYAAYSDPYIGTGGAVSPGQPYDYPQYDPAQQQYSMDTPPGGVWVPQQRATDAAPQPYPEQDPQQQPQQGYPYQGNGEYGQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7A2</accession>
    <name>A0A0F4J7A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_22375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949357.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29648">
        <property type="protein sequence ID" value="KJY29648"/>
        <property type="gene ID" value="VR44_22375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.364"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="24098" checksum="4952B84EF1A0D27E" modified="2015-06-24" version="1">MLALAPPAGPATPVSPRAWRGLWWWLTRRETPAAPAGPGARPYPYTYGTAGRDPGDTAPAPTVSELYHAHRLSMVRLAVLLVDDLGTAEDVVQDAFTALYRRYGEEITEVDNALGYLRTAVVNTARSVLRRRRTARAWVPPVTADVPSAEASVVLDEAHREVLAALARLTPRRRQVLVLRYWADLSEAEIAETLGISRGSVKSNASRALDALERILEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7E7</accession>
    <name>A0A0F4J7E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_21170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949129.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000589.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30105">
        <property type="protein sequence ID" value="KJY30105"/>
        <property type="gene ID" value="VR44_21170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8957"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="555" mass="61721" checksum="C3D8E5DD159879CB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J860</accession>
    <name>A0A0F4J860_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948930.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30577">
        <property type="protein sequence ID" value="KJY30577"/>
        <property type="gene ID" value="VR44_20065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8635"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="458"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="551" mass="59523" checksum="C109ED2250D0D69E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J883</accession>
    <name>A0A0F4J883_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000552">
        <property type="protein sequence ID" value="KJY30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948922.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000552.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30602">
        <property type="protein sequence ID" value="KJY30602"/>
        <property type="gene ID" value="VR44_20025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8627"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="22460" checksum="F88D0726AA01FC30" modified="2015-06-24" version="1">MVTSATPWARATFGAVADQLTEAIPACLMEAHTRARHGHEGVHTQTLEAYGHGLYAAQYETLAAKLSPLSGAIARRLQNRTVMIIGGNVIYPIRYAKKDVPVTAARLRKAAGFRADLIRRHGPEPMQQVLDLGLEELDEEPLHPDVALLPPELRLIIVAYACSMDQGVMRIEWGSAELRREDRYLLWHHHEPLIPPTTPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8B9</accession>
    <name>A0A0F4J8B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY29993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949177.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000600.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29993">
        <property type="protein sequence ID" value="KJY29993"/>
        <property type="gene ID" value="VR44_21415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="41822" checksum="55D89E1F74EDD52D" modified="2015-06-24" version="1" fragment="single">MSGPISLEPGGAHQDTLALRLADTAARPARRAWTETTLALRLPGPNEQEVSRLAAELADRVGPAVHPYEVAALLEAEGLSAELIRERYGHPNIFSLAAALYERVPRVFPEPARAADPWRPDTVRCLLRGVLFALPGLAYLLTAPLWQPGRHAAGPIVAGIVSWAWGQALGHRAYLRMVAGPREAGRTLLAGAPLGAVAATAAGAAAAGGSAVTWAVAAQSLYLAAAGILLVLGRERLLLAALTPLLVGAAVLPWWEPGPLVRTALPALALLATLAAVVRVLRGTYAAPAAPDGGARPPLRKSLPYGLFGLAAAVLVLLEGRTEPYAVIALTVSMGPAEWLLYRFRGLSVTALGAASTPAGFLLRSTGVLGMCLAAYLLLLLPVALLTGAAPAALLLLAATLWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8I9</accession>
    <name>A0A0F4J8I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000589">
        <property type="protein sequence ID" value="KJY30104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949128.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000589.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30104">
        <property type="protein sequence ID" value="KJY30104"/>
        <property type="gene ID" value="VR44_21165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8956"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="325" mass="34210" checksum="8D042A26BAB6EF46" modified="2015-06-24" version="1">MVAGDVGVSSPLRLTDIASQARVSEATVSRVLNGKAGVAAGTRHRVLAAMDLLGYERPVRLKRRSNGLVGLLIPELTNPIFPAFAQVIEQALAGHGYTPVLCTQTPGGATEDELVEQLEERGVTGIVFLSGLHADATADPARYQRLAARGVPFVMVNGFNEHVQAPFVSPDDRAAAEMAVRHLEELGHRRIGLAIGPTRYVPSARKEQGFLTARPGADGEGLVQRTLFTVEGGHAAGIALLERGCTGVVCASDMMALGVIRAARERGLRVPEDVSVVGFDDSPLIRAMATAAVGALLEAVAGTPVQRTEYVFQPELVVRGSTGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8L5</accession>
    <name>A0A0F4J8L5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949148.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30088">
        <property type="protein sequence ID" value="KJY30088"/>
        <property type="gene ID" value="VR44_21275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8980"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="30001" checksum="00C2F3C1FA78B9A9" modified="2015-06-24" version="1">MTPQDASAGAPQGRWSSLDRPPLNASALSRALVSADGLWTSLEVVASTGSTNTDLAARAAELPEGAVLVAEEQTAGRGRLDRSWVAPARSGLFFSVLLKPGPGVPEERWAWLTLLAGVATAAGLSRAAGVDTLLKWPNDLLVTVEGEERKAGGILAERVGDGVVIGIGLNVTLTEDELPVPTAGSLALAKATVTDREPLLKAVLRSLEEWYGRWRDAAGDPGDSGLQETYAAGCATLGRHVRADLPGGRELTGTAEALDTDGHLVIRTAEGERVAVGAGDVVHLRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J939</accession>
    <name>A0A0F4J939_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949454.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29456">
        <property type="protein sequence ID" value="KJY29456"/>
        <property type="gene ID" value="VR44_22890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.512"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16140" checksum="3D75E4B663B94C08" modified="2015-06-24" version="1">MAEQQEGPPRSLADKLNHLFAHVVPAGRGPYSVEDVARAITADGIPISGSYIWLLRKGQRDNPTLRHLEGLAKFFGVPAAYFFDDEVAESVGAELALLMALRDAQVRRMALRTAGLSERSLRSINDVIERVRELEGLPEPPLDDPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9M3</accession>
    <name>A0A0F4J9M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000564">
        <property type="protein sequence ID" value="KJY30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30433">
        <property type="protein sequence ID" value="KJY30433"/>
        <property type="gene ID" value="VR44_20505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8416" checksum="F7E4EFCC8CCCD155" modified="2015-06-24" version="1">MSAWAATFRAASSVRPVVLSRRLPRMRVYSHSPPAARTAAIASAAASAVRARRLLTIVGPRQPSSVVVSPRQPPSAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9R3</accession>
    <name>A0A0F4J9R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30483">
        <property type="protein sequence ID" value="KJY30483"/>
        <property type="gene ID" value="VR44_20355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8780"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="303" mass="33096" checksum="32F12DB085A76169" modified="2015-06-24" version="1">MLNLERLRTLDALARHGSVSGAAGGLHVTTSAVSQQMAKLEREVGQPLLAKHGRGVRLTDAGRILADHAARIISQVELAQADVEAQRGRAVGELRIGAFPTAMRGLLPQTLVSLRTDHPELRVQVREKEPEESMAAVVRGDLDMALAIDWHNKRMPVPAELTRMHLLDDAADIAVPRDHPLAGRTQISLAEFAGDDWISWNEGQFCHEWLVFTLRGTGVEPRVTHIAEEHHTQLAFVEAGLGVCVTPRLGRGPVPPGVRLLPVSDTVRRHVYAVWRADADRRPSIRAAAEALEEAAAAVRDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9S0</accession>
    <name>A0A0F4J9S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948986.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000561.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30488">
        <property type="protein sequence ID" value="KJY30488"/>
        <property type="gene ID" value="VR44_20380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8786"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="78"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="26085" checksum="93F78143FB28BBB7" modified="2015-06-24" version="1" fragment="single">FGLVAVAGVQAFYFASLSRIPVGVALLLEYLGPALLLGWIRFVQRRPVTRAAAAGAAVAVVGLACVVEIWSGLTLDPLGVLLGLAAACCQAFYFVFADQGTDGEDVPDPMGVIAYGMIIGALVMTVLARPWQMDWQVLAGDAALGDLKVPAPVLLGWVVLVATVAAYLTGVVSVRMLSPQVAGVVANLEAVVATVLAWVLLREHLSTWQMVGGALVLGGAFIAQSARPAQEPAVVGESVLPEVGAEAERARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Y9</accession>
    <name>A0A0F4J9Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000524">
        <property type="protein sequence ID" value="KJY31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31000">
        <property type="protein sequence ID" value="KJY31000"/>
        <property type="gene ID" value="VR44_19095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8423"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="99" mass="11086" checksum="C2D463F53EB6CC90" modified="2015-06-24" version="1" fragment="single">ALVPDLDGPPQDPPADLPGLVAAVGFTMQPRILPDRRAAAEAYLARYLDPYTRRYFGRRRLTALGLPGGIPRRLAFLPRHRAVRRAAHRLRRRLGRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Z1</accession>
    <name>A0A0F4J9Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948670.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31187">
        <property type="protein sequence ID" value="KJY31187"/>
        <property type="gene ID" value="VR44_18685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8346"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="264" mass="27410" checksum="2214BD22099FF93C" modified="2015-06-24" version="1">MTTSLEGSWCLVLGASSGIGLANARALAHEGAHVLGVHFDTAEGQEKAEAAVEELRSTGARAHFFNANAASPATRSELVPRFAELTGGAPLRVVLHSLAFGTLLPYLPADGGPALTARQMDMTLNVMAHSLVYWTQSLHAAGLLGAGSKIFAMTSAGDQRVTAHYGAVSAAKCALESHVRQLALELAPQGVSVNSLRAGVTVTPSLERIPGHERLVELAARSNPHGRLTRPEDVAEAVVALARTDSSWITGNVIGVDGGEALTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA49</accession>
    <name>A0A0F4JA49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948884.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30679">
        <property type="protein sequence ID" value="KJY30679"/>
        <property type="gene ID" value="VR44_19825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8584"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15317" checksum="096E80DA07BD7844" modified="2015-06-24" version="1">MRSNDVRSLLQTAVPTAAAGAIAAVISGLVVGGKGAVGALVATVVVILFMGLGFLVLQRTAKTLPHLFQAMGLMLYAAQILLLFVFLAVFKNTTLFHPRAFAITLVATTLVWIGAQTRAHMKAKILYVEPDSVKGEKPENPGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB67</accession>
    <name>A0A0F4JB67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949086.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000581.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30231">
        <property type="protein sequence ID" value="KJY30231"/>
        <property type="gene ID" value="VR44_20925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8915"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="123"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="365" mass="40099" checksum="A155D05F1602A833" modified="2015-06-24" version="1">MATTERSRSGSKTSPMDQLLGELGDYLTAQAGNLADKAADKIDDLTDQLYDVADNGGSLAEIGGRLLGGRLLQGDSPVKAAVGGTIGNLVDKAKEVGGGLLGGKGKSRKGGSKPTHIAESVDIGVPLRTAYDHWTRFEDFSGFAKGVRSVSQDDDTTSAWKVKVGPSTRSWKATVQEQIPDERIVWTSDGPKGTTRGCVSFHELAPSLTRVLLVVEYYPSGLFERTGNLWRAQGRRMRLDLKHFVRHVTLSGDEEPEGWRGEIRDGEVVTTHEEALDQEGEENGEEYEEGEEPDAEEYDEEDEEEDDADGDETEEEDAEEEDEAEPEDEAEPEEEEEAEEERRPRRARRRRPEDGGPASGRMGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBJ6</accession>
    <name>A0A0F4JBJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000483">
        <property type="protein sequence ID" value="KJY31560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948515.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000483.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31560">
        <property type="protein sequence ID" value="KJY31560"/>
        <property type="gene ID" value="VR44_17885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8120"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470906" description="SGL domain-containing protein" evidence="1">
        <location>
            <begin position="41"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="178"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="32802" checksum="1CF57DC59BA007F0" modified="2015-06-24" version="1">MGRNGLSRGGVRRRGRGTTALAVLGVLGAGVLVPAAPAGAAPRCGSSGAGGGPVQVAHVPDWTESIAVDRRGRMFATAYFSGRVYRIDAPGAAPVALTGNIGANGGIVVREDGKLLVGTGNDLAHSLTGDLLPVSKLLEVDPETGDVGVYASGLGGIDGVALAPDGTVYTTTLGGTAIGRVTPDRRVDPAWARVPQPNGIAVSPDGAEVYVVQTTLAPGVYRIPAADPGHPRRWVTATGTDAVGLPDGLTLDGRGRPLIATHAAGEVWRVEDGTLCAVASGPELRLSTQLVYGRGGGGFAAGRLYRAGVDGRVYELPDGAEGPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCW4</accession>
    <name>A0A0F4JCW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase_S11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_16855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32035">
        <property type="protein sequence ID" value="KJY32035"/>
        <property type="gene ID" value="VR44_16855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7806"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470592" description="Peptidase_S11 domain-containing protein" evidence="10">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY32035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="307" mass="31666" checksum="E610FCF78B42A390" modified="2015-06-24" version="1">MRRARGALAVVLTAGALFTAAVPAQAAAAPALTAAGAVLVDGASGSVLTSKAPDTQRQMASTTKIMTAVVVLSQPGLDLDRRVTVKQAYLDYVYLKGASSAQLKAGATPTVRQLLYAMMLPSGCDAAYALADTFGTGTNTAGRTADFIARMNATAKALGMTGTVYDSFDGISPTGNTLTTPRDLARLTRRAMAEPLFQTVVKTTSYSTGGTSYLSAWSNTNLLVQPRPTGYGYPGATGVKTGTTTAAGKCLVFSVTRNGRTVIGVLLGDEERYTDSMALSDWALGPATGSGTALRRSTTAPIPDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFQ4</accession>
    <name>A0A0F4JFQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000464">
        <property type="protein sequence ID" value="KJY31816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948425.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000464.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5601"/>
    <dbReference type="EnsemblBacteria" id="KJY31816">
        <property type="protein sequence ID" value="KJY31816"/>
        <property type="gene ID" value="VR44_17385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8014"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470684" evidence="1">
        <location>
            <begin position="37"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="373"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="509" mass="53592" checksum="7F48DA8F020EF3F6" modified="2015-06-24" version="1">MARSHAKPRLRCTFAAVAAALAALGGVTAITPMAEAAPAASGSITPLSPELEAIRAAEATKIYGDPAIRPLAERKTGLISLGDSEISGEGVGNYDPATNTSANQCHRSPDSAIHRTGIPADLTFNVACSGGYTGNIRIGGSKQYADELVQSDNLAIKARNTKIKMVVLVAGANDDLQFGPVMTDCVTRWVLSQGTCEPKYGPGWQSRVDGLVPKVEATIGDLKTVMRDAGYADSDYKLVVMGYPSPIGPDFNDNPDFPGKLPGGCAGYDSDAAWGRNYAVPTFEKGMRAAALAAGATYLDNSRLFHGHEVCMEDTWARGLYLDLGDHFPWDENTARQSFHPNYRGHGAFASCLTQLYASGLREASCADPASTGTPVLQAGAWDDLYKPLKNEATGNCLDASGGSSANGTKVTGWDCHGGRNQDWWYDTANKSLHVGLTQDRCIDVPGAAYAAGTGLILWNCHGGANQQFVRDGAALHPAAAPALCLTVAAAHDPLRLQPCNGSAAQRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGB0</accession>
    <name>A0A0F4JGB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_17005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948354.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31986">
        <property type="protein sequence ID" value="KJY31986"/>
        <property type="gene ID" value="VR44_17005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7961" checksum="F705CAF63AFA000C" modified="2015-06-24" version="1">MATKAEKIVAGLGGIENIEEVEGCITRLRTEVVNPDLVDEAALKAAGAHGVVRMGTAVQVVIGTDADPIAGEIEDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGM3</accession>
    <name>A0A0F4JGM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_16575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948276.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32116">
        <property type="protein sequence ID" value="KJY32116"/>
        <property type="gene ID" value="VR44_16575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7747"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY32116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="331" mass="35104" checksum="34BABB3BBA3DA223" modified="2015-06-24" version="1">MTRIAINGFGRIGRNVLRALLERDSDLEVVAVNDLTEPATLARLLAYDSTAGRLGRPVSVDGTTLVVDGRRIAVLAEREPERLPWAELGVDIVLEATGRFTSAEAARAHVKAGAKKVLVSAPSDGADVTLAYGVNTDAYDPELHTIVSNASCTTNALAPLASVLDELAGIEHGFMTTVHAYTQEQALQDGPHRDPRRARAAAVNIVPTTTGAAKAIGLVLPNLDGKLSGDSIRVPVPVGSIVELNTTVARDVTREEVLAAYRVAAEGPLAGILEYSEDPLVSSDITGNPASSIFDSELTRVDGRHVKVVAWYDNEWGFSNRVIDTLTLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH24</accession>
    <name>A0A0F4JH24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000348">
        <property type="protein sequence ID" value="KJY33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947733.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33652">
        <property type="protein sequence ID" value="KJY33652"/>
        <property type="gene ID" value="VR44_13555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6972"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14147" checksum="22C7DD81EE0EFDEB" modified="2015-06-24" version="1">MTLTPAEADQILADNFAPWVLALGLTVEETGERHAVLRLPWSDSLARDGGGLSGQALMAAADTATVIAVSAARGAYGPMTTVQQSTSFQRPVVGTDVLITVRVTKLGKRMAFADATMTPDGAQDPAATASTVYALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH32</accession>
    <name>A0A0F4JH32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000421">
        <property type="protein sequence ID" value="KJY32286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948207.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000421.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32286">
        <property type="protein sequence ID" value="KJY32286"/>
        <property type="gene ID" value="VR44_16215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7609"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="11524" checksum="375C7C62FBE66D63" modified="2015-06-24" version="1">MKFAQIIDFETERIEEVRELLRGYEERVRAQGRSGGPVARTLLRDRANPNRYLAVVEFESHEAARANSEAAETNELAQALAALMTRPTVYTDCDVVDRQNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHC1</accession>
    <name>A0A0F4JHC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33747">
        <property type="protein sequence ID" value="KJY33747"/>
        <property type="gene ID" value="VR44_13355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6907"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="462" mass="48084" checksum="F19244504C083F03" modified="2015-06-24" version="1">MAITTRPSAPGGGASGAPAGPAAGRGTAWAEGVERLRAAATTEPGRLRIIGAVLAALVLLFGVVAVWEISGRVTAAEDVVGRSQPLSADAASIYRSLADADTASSSGFLAGAQEPREVRQRYEKDMANASRLLVSAAANTGAGGESRKEIALLGEQLPRYTGLIEQARANNRQGLPLGGAYLRYANEQMSTVLLPAAQRLYEAETGRLYTDYDEARGWPLAATGAGVLALAALVWAQRRNYLLTHRVFNHGLLAATAATAVVLLWLTVGQTVARSGLGEARADGQESLKVLNDARIASLQARANENLTLIARGAVLAEDKKSDKYDVDYAKNMKQLDAGLARALELADDASGRDPVAKAVAGVAQWKQRHAAARESDVRGDYELALPQVIGGKGQKDSSGASFDTVDASLEQAVAHEQKQFTLAARGGLGALGGLVTGAAVLAVVGAGAALLGIGRRLSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJC8</accession>
    <name>A0A0F4JJC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000375">
        <property type="protein sequence ID" value="KJY33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947904.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33061">
        <property type="protein sequence ID" value="KJY33061"/>
        <property type="gene ID" value="VR44_14575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7240"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="25506" checksum="B93D9C4627384080" modified="2015-06-24" version="1">MSKQTILGRVTQLAKANINALLDQAEDPQKMLDQLIRDYANNISEAEQAVATTIGNLRMLEADHQEDVDAAAEWGAKALAASRKADGLRAAGSAAEADRFDGLAKVALGRQMQSEKEAGVAAPVIAAQTEVVGRLKAGLASMKDKLTELQAKRDELVARARTAQAQNSMLDAVKDVDVLDPTSDLHRFEEKVRREEAMALGRQELAASSLDAQFESLEELGRASEIEARLAALKAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK07</accession>
    <name>A0A0F4JK07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polynucleotide kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947546.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34098">
        <property type="protein sequence ID" value="KJY34098"/>
        <property type="gene ID" value="VR44_12605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6587"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="RNA_ligase_T4-Rnl1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_lig_T4_1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="44892" checksum="B30393996451D457" modified="2015-06-24" version="1">MSQDHLTLHDLLPAQALAEAVDAGYVTRKRHPELPLSIYTYTRTAQYERVWNQVTVRCRGLVADDATGAVVALPLPKFFNVGEHESGQPYAPALPDEPFEVYDKVDGSLAVVFHYADRWHVASKGSFVSTQASWAQRRLDACDTAALVPGTTYLAEILYPQNRIVVDYGDRRDLVLLAAFDLTGAEVPLAEAAAHWEGIGSVVRAWPAMPLPELLALTESNTLPGGASATGMDAEGFVLRFASGVRAKAKLSEYVRLHKLLTGVTERDIWRSHGIQRFAGTSAKRLAQGLGLSVAELGGIRSRGGRPLDALLEQVPDEFDTWVREVIARLEEEFERRERAIDEAYKEFEHLADDRAAFARAVREVRDGDLRAAMFLRLDGRPTELVTWRAVRPEAADPFTTDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL90</accession>
    <name>A0A0F4JL90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000342">
        <property type="protein sequence ID" value="KJY33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947699.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000342.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33736">
        <property type="protein sequence ID" value="KJY33736"/>
        <property type="gene ID" value="VR44_13420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6920"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471149" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8155" checksum="E1433324F98369AC" modified="2015-06-24" version="1">MDKKNALRAGAVSAGTALMMLLMTSPALALTRDDGDDPGKGLSIGETLGLYVALPIVIFLVIAGLVMVGDKSRKQPNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLD9</accession>
    <name>A0A0F4JLD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_11040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947252.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34995">
        <property type="protein sequence ID" value="KJY34995"/>
        <property type="gene ID" value="VR44_11040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6092"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="38"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="227"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="4">
        <location>
            <begin position="547"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="689" mass="74686" checksum="E543C3D4547B34C7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JME1</accession>
    <name>A0A0F4JME1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000216">
        <property type="protein sequence ID" value="KJY35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35517">
        <property type="protein sequence ID" value="KJY35517"/>
        <property type="gene ID" value="VR44_10020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5552"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="12886" checksum="6EC044C738552AEC" modified="2015-06-24" version="1" fragment="single">MFLDETSATEALPDPGPGPGPGPGAGAGPGPRPAATAWQADPAHQAGFGGPRDVRVSWGGPDLGEPEDARPAGISLARPAAAAPAARRLPAQAAAESVGILSARPPAWPDAPATGVSGLTSSWPEAAAAPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMF3</accession>
    <name>A0A0F4JMF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947251.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34994">
        <property type="protein sequence ID" value="KJY34994"/>
        <property type="gene ID" value="VR44_11035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6091"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="15129" checksum="727D89E7FA817DB3" modified="2015-06-24" version="1">MSDLLERLRNRGWRMTAQRRVVAEVLDGDHVHLTADEVHARAARRLPEISRATVYNALGELVALGEVAEVSTDGRAKRYDPNARRPHQHLVCSRCGTIRDVHPSGDPLAGFPESERMGFLVSKVEVTYRGLCPSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNP2</accession>
    <name>A0A0F4JNP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000196">
        <property type="protein sequence ID" value="KJY35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007263678.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000196.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5125"/>
    <dbReference type="EnsemblBacteria" id="KJY35825">
        <property type="protein sequence ID" value="KJY35825"/>
        <property type="gene ID" value="VR44_09090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5082"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10064" checksum="AF468CE4F9338D07" modified="2015-06-24" version="1">MITAIVLIKTSVDRIPEIAESIAQLDSVSEVYSVTGTYDLIALVRVARHENLADIIPGRISKIPGVEATDTHVAFRTYSQHDLEAAFAIGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNX5</accession>
    <name>A0A0F4JNX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946825.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36067">
        <property type="protein sequence ID" value="KJY36067"/>
        <property type="gene ID" value="VR44_08750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4994"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="152"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="289" mass="30749" checksum="FF896BEFBED67714" modified="2015-06-24" version="1">MNEHVTVGVDGSAESLAAARWAAQEAVLRQVPLRLVHAVDWLLDPVVPGVGRQDVDSWADQALADASQELRRRHPRLDVTTRALSARPAAALAAEAADADLLVLGSRGLGGLVGFIVGSVAMSTLVATDTPVVLVRPADDPDGPGTGSAAEIVVGLDVHEACDRVLAFAFEEADRRRCPLRAVHGWKMPAAYTYVPFADPGNERDISRSITHMVEDTLLPWRHKFPEVAVSQTVFRGPAAERLVPASQGAQLVVVGRRLRRSPLGMHLGSVAHAVLHHAAAPVAVIAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPV3</accession>
    <name>A0A0F4JPV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946867.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35879">
        <property type="protein sequence ID" value="KJY35879"/>
        <property type="gene ID" value="VR44_08940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4959"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="23886" checksum="397BF7AD99412F51" modified="2015-06-24" version="1" fragment="single">TSGFTGSPWLGTAAAALAAAAYSLILAVGAVTLRGDAVVLGVAMNLLALGLTGFLLRTVFGVRGTFDDPALTGLPLIGGQSPLAYLSWAAVALTAFVLTRHVWGLRLRGAGQAPDAAAALGVSPVAYRYAAVLASGVLCGLGGAQLALGNVTLFSENMTAGRGWIAVVAVMLGRAAPVGVLLSALLFALAEAVGFRLQGLGLPQQATDAAPYAVTLAALFLTTARRRRAARTTTGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPW5</accession>
    <name>A0A0F4JPW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35798">
        <property type="protein sequence ID" value="KJY35798"/>
        <property type="gene ID" value="VR44_09225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5109"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="31"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="25955" checksum="AE79FEFF77F2585F" modified="2015-06-24" version="1">MRNAVRQELVGRQVEEQITQRFPVGQRLRVLDVGMGQGTQALRLARAGHMVTGLEQDAAMLAVAHAALAAEPAGIRDRVELIEGDGRETGAHFGPGSFDVVLCHGVLMYVSEPDAMLAGLARMLAPGGLLSLLVRNGDALALRPGLSGDWSGALDAFDTVDYTNRLGLEVRADRLADLTATLSGIGAPLHTWYGVRVFTDGTEAAAELPPEEELELLLAAEERAGRTDPYRSVAALLHLCGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRN2</accession>
    <name>A0A0F4JRN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000158">
        <property type="protein sequence ID" value="KJY36484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36484">
        <property type="protein sequence ID" value="KJY36484"/>
        <property type="gene ID" value="VR44_07920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4405"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="7950" checksum="21F6C4D9F63A6A19" modified="2015-06-24" version="1" fragment="single">RQAPPPGRVRSAFAGEGVRTLRADGPGWSLVARTGDAAFVLLDEEPGGVLAVPREGAGGLPALPGLLEALDRVAVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSB8</accession>
    <name>A0A0F4JSB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000122">
        <property type="protein sequence ID" value="KJY37060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946442.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37060">
        <property type="protein sequence ID" value="KJY37060"/>
        <property type="gene ID" value="VR44_06650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3248"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="27430" checksum="141BFDB892EB3770" modified="2015-06-24" version="1">MLVLLPPSEGKAAGGSGAPLDPASLSLPGLAGARAAVLEELVELCAGDELKAREVLGLSEGLRGEVAKNAALRSAPALPAGEIYTGVLYDALGLADLPAAARALAERTLLVFSGLWGAVRVTDRIPSYRCSMGVKLPGLGALGAYWRTPMAEVMPEAAGDGLVLDLRSSAYASAWKPKGETAGRTATVRVLHSQIVDGVEKRSVVSHFNKATKGRLVRDLLLAGAEPAGAAELVAALRDLGYVVEAEAPAKAGRAWALDVVVTQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSS2</accession>
    <name>A0A0F4JSS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VR44_06955</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946497.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5287"/>
    <dbReference type="EnsemblBacteria" id="KJY36884">
        <property type="protein sequence ID" value="KJY36884"/>
        <property type="gene ID" value="VR44_06955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3606"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY36884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="475" mass="51658" checksum="69EBAFE5F60D94C8" modified="2015-06-24" version="1">MRRAKIVCTLGPATDSYDQIKALVEAGMDIARLNLSHGTYAEHEERYQRVRKASDETGRSVGILADLQGPKIRLGRFHEGPVLLERGDEFTITTEDHPGDRHTCGTTYKGLAHDVTTGERILVDDGRVTLEVTAVEGPRVHTRVIEGGMVSDHKGLNLPGVAVSVPALSDKDIEDLRWALRTGVDVIALSFVRTGRDIEDVHRIMDEEDRRLPVIAKIEKPQAVENIDDIVAAFDGIMVARGDLGVEMPLEQVPIVQKRAIKLAKRNAKPVIVATQMLDSMIDNSRPTRAEASDVANAVIDGTDAVMLSGETSVGKHPVETVRTMARIVAAAEEDILAKGLPPLTDRNKPRTQGGAVARAAAEMGDFLDAKYLVAFTQSGDTVRRLSRYRSPIPLLAFTPDPATRSQLNLTWGVETFLGPHVDSTDAMVAQVEEELLRIGRCQRGDIVVITAGSPPGVSGKTNLVRIHHIGDPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT53</accession>
    <name>A0A0F4JT53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000128">
        <property type="protein sequence ID" value="KJY36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946491.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000128.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36923">
        <property type="protein sequence ID" value="KJY36923"/>
        <property type="gene ID" value="VR44_06920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3468"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="406" mass="41534" checksum="192B2348BC8C78E7" modified="2015-06-24" version="1">MTALGRPAGGPETAPASQQGMRRQNLAAVLGAVAAHGPLSRADVAGHTGLTRPAVSSLVDELIGRAALAETETAPSGRVGRPGRALALDDRGPAGLGLEIGVTHLAACVVDLRGEPRVWRRVERANAGRPAARVLEEAAALGADAESEAAALGLRVEGRVLAVPGVVPNDPGGLVAHAPNLGWRAVRPADHWPDPATVPEPENEANLGALAEQRHLGHPAETFVHVSAEAGIGAALVIDGRLFRGARGFAGELGHLPVHPEGAPCPCGARGCLEQYAGEAAVLREAGLAGAHDPVAVLAERAGAGDAATLRALDRAGRALGLALVPAVDLIDPDGLVLGGAYAELADWLLPPVRAELAARVTVRPWTPEAVRPSALGRRGPVLGAAWSTVQRIIADPARLPFRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU32</accession>
    <name>A0A0F4JU32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946182.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7117"/>
    <dbReference type="EnsemblBacteria" id="KJY37670">
        <property type="protein sequence ID" value="KJY37670"/>
        <property type="gene ID" value="VR44_05300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1695"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032633">
        <property type="entry name" value="ThiJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17124">
        <property type="entry name" value="ThiJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="30522" checksum="4A3936204D9A0DF3" modified="2015-06-24" version="1">MSRKILVIVSEHGYWSEELIGPVSKFDEQGYEITFATPTGKRAHALPPSLDPNFVDPPLGRSVTSEENARLGREFEQSNRLDTPLDIEAWVPERPYTSDGEYLRKLEQYHRDLEKLEADIAGYDAILIVGGSGPIVDLANNERVHALILAFKNAGKVVAAECYGVACLAFARDWGDRKSIIWGKHVTGHCKEYDYKDGTGFLGTDFNMGPPPYPLEYILRDATGPRGAYHGNFGHPLSVIVDYPFVTGRSTPDSYLTGQKIVEVLENGLTRYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU40</accession>
    <name>A0A0F4JU40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37680">
        <property type="protein sequence ID" value="KJY37680"/>
        <property type="gene ID" value="VR44_05365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="165" mass="18018" checksum="6FCF184BD54BC4D2" modified="2015-06-24" version="1" fragment="single">MPSTTVIILDVHPLPPAELLEALRLMDAELVTPTLPHLMRGRLDALPAGDVLLVPAEADGDIVRAVVRRLRRWAGAPVVVAWTVGDYAALERHVRLGHDYLVPPFLPALVAARLRSCTERAGLGRTVQEADARAELMGYEKELEIGREIQAGFLPESLPVPAGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUA4</accession>
    <name>A0A0F4JUA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946144.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene161"/>
    <dbReference type="EnsemblBacteria" id="KJY37755">
        <property type="protein sequence ID" value="KJY37755"/>
        <property type="gene ID" value="VR44_05070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1329"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="13106" checksum="AFF0C495E1C99846" modified="2015-06-24" version="1">MDRVALRGLKARGHHGVFPREREEGQTFIVDLVLHLDTRPAAAGDDLAKTVHYGVVAEEVVEVVQGEPVDLIETLAERIAQQCLKHEAVAQVEVVVHKPDAPITVPFDDVTITITRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUP5</accession>
    <name>A0A0F4JUP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_04720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000087">
        <property type="protein sequence ID" value="KJY37905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946078.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37905">
        <property type="protein sequence ID" value="KJY37905"/>
        <property type="gene ID" value="VR44_04720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1025"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="33911" checksum="F23E4579A74608F4" modified="2015-06-24" version="1">MRSSAIAVSGLRKAYGDKVVLDGIDFDVAAGSVFSLLGPNGAGKTTTVNVLTTLMKADAGTVRVAGYDVAAETRQVRGAIGVTGQFAAVDELLTGRENLQLMADLKRVRDGGRLVTGLLERFDLAGSADKQASTYSGGMRRKLDLAMTLVGSPQVIFLDEPTTGLDPRSRRTMWGIVRELVAEGATIFLTTQYLEEADQLADRIAVLNQGRLVAQGTPEELKGQIPGTHVRFRFADLAGLDAAARVLLEATRDDEELTLSVPGDGGTRSVRALLDRLDAHGLDAEEFSVQRPDLDDVFLALTDQPAGVQNTSKEAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV23</accession>
    <name>A0A0F4JV23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uridylate kinase</fullName>
            <ecNumber evidence="4">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Uridine monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_04055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000074">
        <property type="protein sequence ID" value="KJY38212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945960.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene734"/>
    <dbReference type="EnsemblBacteria" id="KJY38212">
        <property type="protein sequence ID" value="KJY38212"/>
        <property type="gene ID" value="VR44_04055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="213" mass="22958" checksum="208FA49C07629A77" modified="2015-06-24" version="1" fragment="single">MNQGVDPHTASHDKSDHEKKGRRFMLKLSGEAFSGGGGLGVDPDVVHAIAREIAAVVRDGAEIAVVIGGGNFFRGAELQQRGMDRARSDYMGMLGTVMNCLALQDFLEKEGIDSRVQTAITMGQVAEPYIPLRAVRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIDAEALLMGKNGVDGVYDSDPKTNPDAVKFDALEYNEVLSRDLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV94</accession>
    <name>A0A0F4JV94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_07025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946509.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5298"/>
    <dbReference type="EnsemblBacteria" id="KJY36896">
        <property type="protein sequence ID" value="KJY36896"/>
        <property type="gene ID" value="VR44_07025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3620"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="120"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="642"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY36896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="756" mass="81899" checksum="6BF76CE21DB4A7D6" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVG3</accession>
    <name>A0A0F4JVG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000127">
        <property type="protein sequence ID" value="KJY36936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946484.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000127.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36936">
        <property type="protein sequence ID" value="KJY36936"/>
        <property type="gene ID" value="VR44_06880"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="388" mass="42201" checksum="DADE672D671B10C2" modified="2015-06-24" version="1" fragment="single">MPSRTSPAQEIWFLTGSQHLYGEETLKQVAEQSRQLAAALDDASGMPARVVWKPVLTDADAIRRLCLDANAEDRCTGLIAWMHTFSPAKMWIAGLDALRKPLLHLHTQSNRALPWETIDMDFMNLNQAAHGDREFAHVQARLGVPRKTVAGHVTDPLTIARVAVWGRAAAARSELATLRTARFGDNMRDVAVTEGDKVEAQLRLGVSVNTYGVNDLVEVVDGAEESEVASLVEEYADLYDLAPELRRGGERHGSLRYAARIEAGLRTFLESGGFRAFTTNFEDLGGLRQLPGLAVQRLMAQGYGFGGEGDWKTAVLLRALKAAAAGLPGGTSFMEDYTYDMTPGNELILGAHMLEVCPTLTTARPACEIHPLGIGGREDPVRLVVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVJ8</accession>
    <name>A0A0F4JVJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36971">
        <property type="protein sequence ID" value="KJY36971"/>
        <property type="gene ID" value="VR44_06740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3427"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="44418" checksum="E0C28A121392F158" modified="2015-06-24" version="1">MLGGRVRDQAHTRRGTRMTWRTLTVLNDRNAGLYLGGVIVSGFGDTAMSLAAGIWVKTLTGSDGLAALVGFCLWLPTFAGPLIGTAADRVRRRPLLVATNLVLAAVVTAPVAVRSAADVWLLFAVLTLVGTGMVLTDAAQSALIAAAVPQELRGDFNGLVYTAMESTKLLAPLAGAWLFTAYGGPAVAVLDAVSFVLAALAFRFIRVREELPAAREERAWTARTAEGTRYLWQHPVLRPLVLTGGTAMTLSSLSSTATFAMLDAGLHQSPAYAGVLTPVQGLGSVVSGLTAGALMRRTSERTFSAIGLALFALGVLARATPWLPLVLGGSLAIGLGLPCALIAAMTAVQRETPGELLGRVTATANTLMFAPTGLALLAGSAMVAGLDYRVQLLTAGALGLAWAAALTLTGRPAGPSPRPGRRPSESARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK1</accession>
    <name>A0A0F4JVK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945907.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38397">
        <property type="protein sequence ID" value="KJY38397"/>
        <property type="gene ID" value="VR44_03750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8653"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="27698" checksum="4F7D99BAF704D60A" modified="2015-06-24" version="1">MSRRRIGFWYRLAAVIAKPPLVVLFKRDWRGMEHIPADGGFITAVNHNSYLDPLSYAHFQYNTGRVPRLLAKAGLFKVPFVGAILRGSGQIPVYRETTNALDAFRAAVAAVERGECVAFYPEGTLTRDPELWPMAGKTGVARVALVTRAPVIPVAQWGANHVMPPYAKENKVRLFPRKTLQVLAGPPVDLSAFYGKEPTPEVLKGATEAIMADITRLLEELRGEKAPDQPYDHRKARAQQRRKAAGEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK2</accession>
    <name>A0A0F4JVK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946464.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36976">
        <property type="protein sequence ID" value="KJY36976"/>
        <property type="gene ID" value="VR44_06770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3433"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="144"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="41947" checksum="0014C1DD9531E69B" modified="2015-06-24" version="1">MAPRPSLKERRFWQPERSPALLVIPLGLIVTVCVVDVLAPPHVHLGPLLVAAPAITVAFAGARTTAAMGALAVAAQVLIGVLRGVVGTANVQAQIAALIVVSAVCVTVCVVRDRHERQLHQVRSVAEAAQRVLLQPLPARSGPLRIAGLYIPADAEAELGGDLYAAARTAHHSTRLLIGDVRGSGLGAISKTALLLGAFRAAAHRQASLPRLAVHLDAAFRWDTGQWRPRTQEDTTEDFATAVLLDIPDHEPVVHLISCGHPPPLILRGKRIIPLVAEASHLPIGFGGAFGITDYVVQTFPFEAGDLLLLYTDGVIEARSADGRFYPFTERAPQWTGDEPDELLRRLQADLLAHVHAHLDDDAAVVAVRRTASDPPASDPATAWAAPRPPTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVM2</accession>
    <name>A0A0F4JVM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000091">
        <property type="protein sequence ID" value="KJY37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946122.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37798">
        <property type="protein sequence ID" value="KJY37798"/>
        <property type="gene ID" value="VR44_04945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1076"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23040" checksum="F606B3EA8DCE72E9" modified="2015-06-24" version="1">MRIAVAEDLYLLRDGMVRLIEAFGHEVVATAATGPETLDVLRTHRPDVSVIDVRMPPAQSDEGLRAALTARSEIPGLPVLILSQHVEQLYARELLADGTGGVGYLLKESVFDADQFIGSLERVAAGGTAMDPAVIAKLLSGSAPDRGLERLTEREGSVLALMAEGLSNHAIARRLFLSEGAISKYTTSLFGKLGITDDDDTNRRVRAVLAYLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWL1</accession>
    <name>A0A0F4JWL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">VR44_03945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945941.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene755"/>
    <dbReference type="EnsemblBacteria" id="KJY38234">
        <property type="protein sequence ID" value="KJY38234"/>
        <property type="gene ID" value="VR44_03945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8694"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="34"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY38234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="470" mass="52129" checksum="7AACE0036C1F2BFB" modified="2015-06-24" version="1">MAKAPVLTPQAEDFPRWYQDLINKAELADNGPVRGTMVIRPYGYGLWERMQQEMDARIKEAGAQNAYFPLFIPQSYLTREAEHVEGFAPELAVVTHGGGKELEEPVVVRPTSETIINDYFSKWVQSYRDLPLLINQWANVVRWEMRPRVFLRTSEFLWQEGHTAHATYEDARDYAAHIHRNVYGDFMTNVLGIDVVLGRKTPKERFAGAINTLTLEGMMGDGKALQMGTSHELGTNFAKAFNTSYLSKEGQQELVWQTSWGVSTRMVGGLIMSHGDDNGLRVPPRLAHVQVVVMAIKGDEAVAKVRELGAQLKAAGLRVHVDDRVDTPFGRRAVDWELKGVPVRIEIGPRDLENGTAMLARRIPGGKEPVQIDALADLLPKVLDEDQAQLLRESRERRVSRTSDVATIEEAAEAALAGGWARIPWSVLGPEGEAKLGEQAVTVRCLVAEDGSVPESDDAPGTLAIVARSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXW3</accession>
    <name>A0A0F4JXW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_02570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000040">
        <property type="protein sequence ID" value="KJY38965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945692.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38965">
        <property type="protein sequence ID" value="KJY38965"/>
        <property type="gene ID" value="VR44_02570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6818"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="30638" checksum="8DDF3BF9C869DADC" modified="2015-06-24" version="1">MTTTAPPESTVLRRRPGLRPLRLLAQGPLFTASVAVLALLVLIAVLAPVIAPYDPEALDLTASLAGTTGEHLLGTDQSGRDVLSRLMYGARTGLLGPLLVVGVSTLLGTLLGVVAAWRGGWADSVLSRSMDMVFAVPGLLLAILLVSVVGPGMTAPVIAMAVAYTPYVGRLVRGIARQEKARPYIESYRVQGWSGWNVCLRHLLPNIAATVFAQSAMNFGYALMDLAALSYLGFGVQPPTADWGAMINEGQSAVQQGAMLPALAPSACIVLAVVAFGIVGEGLADRIARRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY44</accession>
    <name>A0A0F4JY44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945672.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39045">
        <property type="protein sequence ID" value="KJY39045"/>
        <property type="gene ID" value="VR44_02410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6771"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="15560" checksum="C32F28EE3B6F2D46" modified="2015-06-24" version="1">METNQGTPRIVVGVDGSPSSQAALRWAVRYAGLVGGKVEAVTAWEVPGEASWSAPAVDATFDEEEAEKLLVDEVRTVLGDRGAALVRERLVHGHPVGVLVDAAQGADMLVVGSRGRGAFRRALLGSVSQQVALHAPCPVTIVRPDVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYI8</accession>
    <name>A0A0F4JYI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="8" type="ORF">VR44_01705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945529.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39422">
        <property type="protein sequence ID" value="KJY39422"/>
        <property type="gene ID" value="VR44_01705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5743"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY39422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23309" checksum="21417631882B2063" modified="2015-06-24" version="1">MSEETPGFDEKPEVPTGADDAEPKAADSSEEKEAAPAGDAAQETALLAQLDQARTALNERTADLQRLQAEYQNYRRRVERDRVAVKEIAVANLLSELLPTLDDIGRAREHGEVVGGFKSVAESLETAAAKMGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAEPQPGAAPAAKSESGDGDTPSEKDTDAPDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZJ3</accession>
    <name>A0A0F4JZJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39138">
        <property type="protein sequence ID" value="KJY39138"/>
        <property type="gene ID" value="VR44_02160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5695"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023895">
        <property type="entry name" value="Thiopep_bacteriocin_prcur"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03892">
        <property type="entry name" value="thiopep_precurs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="11858" checksum="8E56E1A9C2D15944" modified="2015-06-24" version="1">MAGCAAPRRPPRPAAELTTAVRRRHDRARRPALRRKTAGGRLPRCIRGSREKRKGIRMDNLTAEDFASFELEDLEILDVVDGVALPEMGASNLGSWLCCSSSSSGSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZN1</accession>
    <name>A0A0F4JZN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945895.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5759"/>
    <dbReference type="EnsemblBacteria" id="KJY38446">
        <property type="protein sequence ID" value="KJY38446"/>
        <property type="gene ID" value="VR44_03610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8260"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="331" mass="36070" checksum="67CBE90D740B4A92" modified="2015-06-24" version="1">MRIFGKVRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLEPWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLARRAWQAYGLKVPGDPHSTAGTGEPVGMELGSAAVRLSPEGEAEVVWGRRLDPARMEVLSIPLPSSGRRWGEVVLHDGVPHGERVTAAGPSYPVFDEIELWAPSPVPTWVVLLEAATEEDRDALEQLASDAGFAAEDWSSSVRLLCRTCSESSMPSGEGNGDHLDPHDHSEPGHPGPLGHRTAGSGSLWVPERECGIAAPAGLVRGLLDGWVADSPDSREWRDLEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0E8</accession>
    <name>A0A0F4K0E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945428.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39579">
        <property type="protein sequence ID" value="KJY39579"/>
        <property type="gene ID" value="VR44_01140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2942"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="32676" checksum="61EB5E273C712C33" modified="2015-06-24" version="1">MSLRLSTVILPVRPWHGGGRDQWERAERLGFHTAYTYDHLTWRTFRDGPWFGAVPTLTAAAAVTDRLRLGTLVTSPNFRHPVTLAKELMSLDDISGGRITLGIGAGGNGFDATALGQEEWTPRERADRFAEFVPLLDRLLTESAVTQRGTFYSAEEARGIPGCVQRPRLPFAVAATGPRGMKLVAKHGQAWVTTGDPKVFEGTPEQSIEALRGQVGKLDKALAEAGREPGSIERILLTGFTPERGSMLESVDAFVDFAGRHRELGFTELVIHAPIPDSDFAADEAVFERIATEALAQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0Q2</accession>
    <name>A0A0F4K0Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945493.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4185"/>
    <dbReference type="EnsemblBacteria" id="KJY39503">
        <property type="protein sequence ID" value="KJY39503"/>
        <property type="gene ID" value="VR44_01500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4733"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="458" mass="49978" checksum="4DAFB43A0096B776" modified="2015-06-24" version="1">MTDTSSRLNTGSHDLPVSAELSRFMAGNWAPSPLPAGSRVTAYEVTPARRARLSARFPGERLIIPAGELRVRSNDCDFRFRPHSAYAWLTGLTGEDQVGHVLVLEPAGAHGHEAVLYLRPRSDRSDGTEEFYRDRRYGEFWVGRRPDLAEAERLTGLRCAHLDAIGSPTGRNAATDTELAAALSELRLVKDAWEVDQLQLAVDHTAAGFEDVVRALPTALAHPRGERWIEGVFNLRARAEGNGLGYETIAASGAHACVLHWIRNDGRLDRDELLLLDAGVETDSLYTADITRTLPLSGRFSPVQKQVYELVLAAQEAGIAALRPGASFRDFHRAGMRVIAEGLAEWGVLKDADGDLHRRYTLCSSGHMLGLDVHDCAQARAGTYLDGVLEEGQVLTVEPGLYLQPDDETLPAELRGMGVRIEDDLVITSDGARLMSGALPRTVSGIEEWMGTLLDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1P1</accession>
    <name>A0A0F4K1P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000030">
        <property type="protein sequence ID" value="KJY39136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945610.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39136">
        <property type="protein sequence ID" value="KJY39136"/>
        <property type="gene ID" value="VR44_02135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5691"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="42061" checksum="3CBDC73FB997B8C0" modified="2015-06-24" version="1">MAAADTAARLGAELLVLGAEAGPAATAPVPADVAIVCAPGELLGAELARVAALLPPGCPVVPVRADSRFHLVGPQVAGASGYPGTVAARVGHWVDTPGAAPLGAAAGALAGALAGQLAYRVLTGTGAPGESAYVVHGPELNASRIDLAPLPPAGPAAGLDEAVARVQAVAARWTGPFALVTPENLPQLPLGVAEAEHRDGTAGSVAAWGADQRSSSVAAALAALRAQQHAGPEAVAAAGTSEEGWLLDGTLRLLAGRAEPVGDAPAFEDLDKAGQVLWRTLEDHEFLTVGLSLLRVPGVDWPLAVVHDRATGRDVASAWGPDRTAASVAALSTALTRVQTLRIRGRELVTAAPDTTALLHADTAALSALAAQTRLWLTPTGTRAADPVAGETPLWFGTVTARPATDALEEALPKEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1R4</accession>
    <name>A0A0F4K1R4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="7" type="ORF">VR44_00025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945250.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene974"/>
    <dbReference type="EnsemblBacteria" id="KJY40054">
        <property type="protein sequence ID" value="KJY40054"/>
        <property type="gene ID" value="VR44_00025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY40054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12827" checksum="994F1EE28F2D36CB" modified="2015-06-24" version="1">MHLAYPAVLAALLFATGLYGVLARRNAILVLMSVELMLNAVNLNLVAFDVWLRDTLHAGQALTLFTIAIAAAEIGIGLAIVLMVYRNRGTSDVDKLRDTAERHESGRPDDTAARPEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6L7</accession>
    <name>A0A0F4I6L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphopantetheine--protein transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001759">
        <property type="protein sequence ID" value="KJY16381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16381">
        <property type="protein sequence ID" value="KJY16381"/>
        <property type="gene ID" value="VR44_40480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="8449" checksum="5DD98EF91BBD4DC4" modified="2015-06-24" version="1" fragment="single">RFGDRLHLLPACTDAFLLDVRLSTVRAREAALERALAPVESDYDVILIDCPPSLGLSMDAAIYYGRRRDTEQPGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9L9</accession>
    <name>A0A0F4I9L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001620">
        <property type="protein sequence ID" value="KJY18153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5467"/>
    <dbReference type="EnsemblBacteria" id="KJY18153">
        <property type="protein sequence ID" value="KJY18153"/>
        <property type="gene ID" value="VR44_39670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6051"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="302" mass="33055" checksum="239A36A43788A036" modified="2015-06-24" version="1" fragment="single">MTVAPLNPRLRTLGTRIAGPGRPVYVVGEIGINHNGDLGTAFALIDAAAEAGCDAVKFQKRTPELCTPRDQWDVERDTPWGRMTYIDYRHRVEFGEADYLALDEHCAKRGIDWFASPWDTEAVAFLEKFDLPAHKVASACLTDDELLRALRATGRTVVLSTGMSTPKQIRHAVEVLGSDNILLCHATSTYPAKAEELNLRVINTLQEEYPNVPVGYSGHETGLQTTLAAVALGAVLVERHITLDRAMWGSDQAASVEPGGLTRLVRDIRTIEAALGDGVKKVYDSELAPMKKLRRVQGTLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAV8</accession>
    <name>A0A0F4IAV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_39535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001599">
        <property type="protein sequence ID" value="KJY18608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952530.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001599.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7190"/>
    <dbReference type="EnsemblBacteria" id="KJY18608">
        <property type="protein sequence ID" value="KJY18608"/>
        <property type="gene ID" value="VR44_39535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5997"/>
    <dbReference type="eggNOG" id="ENOG5030H85">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY18608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="377" mass="41939" checksum="8931BD6F2C0A7969" modified="2015-06-24" version="1">MPADRPVPLDEYPVHQAPLSMKHLVTGDRNAYDRCIFHVFDHAGRAVLILGLGVYPNTGVIDAYATLRLGDELLAVRASDALTDDRMNLSVGPLSIIVDAPLKRLTLRCDPDPEDPSGLSYDITWTAEFPAVWEPHHIQRRGDRLMLEGRRFVQAGNVTGTVRARGEEFTLTPGEWTGTRDRSWGVRPIPGEDGGRAAEEMRPEGFHWLWVPVRFEDRFVMVIAQEDADGHRTLNEAVQVFPEDSGRHDVQLGWPHTEIRYRPGSRHPERAVVHLTDPSRKPLELGVEILNSSPLAVGAGYPPAADWQHGSWQGRGWTDRRAYDLSDPAAHPMAAFGVTDHSARFTLDGRTGFGIFEHGSFGRHDPSGFADYTSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIR2</accession>
    <name>A0A0F4IIR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">VR44_38230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01001450">
        <property type="protein sequence ID" value="KJY21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952283.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001450.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene581"/>
    <dbReference type="EnsemblBacteria" id="KJY21569">
        <property type="protein sequence ID" value="KJY21569"/>
        <property type="gene ID" value="VR44_38230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5255"/>
    <dbReference type="eggNOG" id="COG1540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="26240" checksum="29186B3C363963E6" modified="2015-06-24" version="1">MITSPAAAIDLNADLGEGFGRWTLTDDEALLSVVTSANVACGFHAGDPSIMRRVCELAAARGVRIGAQVSYRDLAGFGRRAMDVPARELAAEVAYQIGALEVFARAAGSRVSYVKPHGALYNRTVHDAEQAGAVVAGVRLAAGEAGLPVLGLPGSLLLAAAAEAGLEAVPEAFADRAYTPAGTLVPRGTPGAVLHDPDAVVARAVRMAAQGEVTAADGSPVRVSARSLCLHGDTPGAAGLAVRVREALGAAGVRVEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IK00</accession>
    <name>A0A0F4IK00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001436">
        <property type="protein sequence ID" value="KJY22004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952259.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001436.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1550"/>
    <dbReference type="EnsemblBacteria" id="KJY22004">
        <property type="protein sequence ID" value="KJY22004"/>
        <property type="gene ID" value="VR44_38095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5223"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY22004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="13963" checksum="129730609B92F64A" modified="2015-06-24" version="1">MQSYTIGQAARLLGVSPDTARRWADAGRVATHRDEAGRRLIEGRDLAAFSVEVGQGAHTEDGEPYTSARNAFPGIVTAVTLGDVAAQVEIQAGPHRLVSLLTREAVEELGLEVGMQATARVKSTSVHIDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IL79</accession>
    <name>A0A0F4IL79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001410">
        <property type="protein sequence ID" value="KJY22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952200.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001410.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22762">
        <property type="protein sequence ID" value="KJY22762"/>
        <property type="gene ID" value="VR44_37790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5064"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY22762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="15721" checksum="D7535719B5C768B0" modified="2015-06-24" version="1" fragment="single">MTSLLVIAKAPVPGRVKTRLTPPFTPGQAAALAEAALADTLAAVLATPADRHVLVLDGAPGPWLPPGFEVVPQRGRGLDERLAAAFADCAGPALLIGMDTPQVTPGLLAPALVFDTCDAWFGPAADGGFWALGLAAADPALLLGVPMSVPETGAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQK7</accession>
    <name>A0A0F4IQK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylylsulfate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001249">
        <property type="protein sequence ID" value="KJY24320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24320">
        <property type="protein sequence ID" value="KJY24320"/>
        <property type="gene ID" value="VR44_35695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="38" mass="3971" checksum="C7C32A1FC409D346" modified="2015-06-24" version="1" fragment="single">MSVTGQGATVWLTGLPSAGKTTIAYALAERLRAEGHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQX5</accession>
    <name>A0A0F4IQX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001232">
        <property type="protein sequence ID" value="KJY24407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951766.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001232.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24407">
        <property type="protein sequence ID" value="KJY24407"/>
        <property type="gene ID" value="VR44_35470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4208"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9041" checksum="99C4624EBFE3FE33" modified="2015-06-24" version="1">MTDTLVWFALICSVLGTGVTAWTSSGVGRLHHLDARELRRQQRFEDILSLHVEETGPPRTTLPPGAPEAADTAACAACGSSSVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS70</accession>
    <name>A0A0F4IS70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001219">
        <property type="protein sequence ID" value="KJY24489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951720.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001219.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24489">
        <property type="protein sequence ID" value="KJY24489"/>
        <property type="gene ID" value="VR44_35215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4124"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="222" mass="23582" checksum="D0BCA7F09C813C3B" modified="2015-06-24" version="1">MIRVLIADDQPLVRRGLSLILAPHPDVEVVGEAGDGAEAVALARDLHPDVVVMDIRMPVLDGVRATAELASARPASRVLALSTFDMDEYVVAALRAGAYGFLPKDVSPEELIAAVRTVHTGEAVVAPRLLTRLISTYVRATAREPRPAPAAPAGLTPRELEIWRLLATGFDNAGIAAELDISVSTVKNHLTGVFGKLGVRDRAQAVIAAYESGLVEAERRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISB3</accession>
    <name>A0A0F4ISB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001210">
        <property type="protein sequence ID" value="KJY24534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24534">
        <property type="protein sequence ID" value="KJY24534"/>
        <property type="gene ID" value="VR44_35080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="23925" checksum="C357955BC11FB4AE" modified="2015-06-24" version="1" fragment="single">PQQRLLLETGWEVLERAGIDPATLRGTRTGTFVGAMNQDYGPRLHEAPEDISGYLLTGNSVSVASGRLAYTFGFEGPAVTVDTACSSSLVALHLAAQSLRTGECSLALAGGVTVLPTAGSFVEFSKQRALAPDGRSKAFSADADGFGLAEGAGMVLLERLSDARRAGHRVLAVLRGSAINQDGASNGLTAPSGPAQQRVIRQALANAGLTAADVDAVEAHGTGTRLGDPIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT61</accession>
    <name>A0A0F4IT61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001189">
        <property type="protein sequence ID" value="KJY24653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951621.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001189.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4265"/>
    <dbReference type="EnsemblBacteria" id="KJY24653">
        <property type="protein sequence ID" value="KJY24653"/>
        <property type="gene ID" value="VR44_34695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4004"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="23543" checksum="C8CE2C3140C9E323" modified="2015-06-24" version="1">MKSDLFASENLAQPAAAPGMSLQNAKSVKYTVNGEMLARQGSMVAFRGNLQFERKGQGIGGMLKRAVTGEGLALMSVRGQGEAWFAHQAGNCFVIDFEPGDALTINGRNVLCFDATLSYEIKMVKGAGMTGGGLFNSVFTGTGKLAVVCEGNPIIIPVTSQSPVYVDTDAVVGWSAQLETGLHRSQSIGSMIRGGSGEAVQLMLRGEGFVIVRPSEHTETAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT66</accession>
    <name>A0A0F4IT66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001188">
        <property type="protein sequence ID" value="KJY24658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24658">
        <property type="protein sequence ID" value="KJY24658"/>
        <property type="gene ID" value="VR44_34675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3925"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="17859" checksum="F68C3368756F5373" modified="2015-06-24" version="1">MAPTAASRAGEYAARFAELLLRAEREALVRRPAPGVWSPLEYACHVRDVLLVQRERVLAARRTDKPVATPMGRDERVEHEGYALQDPAAVARQLTDAAALFGNVLHRLPPAHWERTLVYSYPEPAERSLSWVAVHTLHELRHHLRDARCRLPDPPAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT96</accession>
    <name>A0A0F4IT96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001104">
        <property type="protein sequence ID" value="KJY25235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951322.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001104.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene110"/>
    <dbReference type="EnsemblBacteria" id="KJY25235">
        <property type="protein sequence ID" value="KJY25235"/>
        <property type="gene ID" value="VR44_33055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3483"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="30137" checksum="C73954506D7F0E27" modified="2015-06-24" version="1">MVRNPSSSAPKVALSTASVYPESTATAFEIAARLGYDGVEVMVWTDPVSQDIEALRRLSDHHKVPILAVHAPCLLITQRVWSTDPWTKLQRAQAAAEKLGASTVVVHPPFRWQRQYARDFVSGIWRMADETDVRFAVENMYPWRYRDREMLAYAPEWDVTKDDYRHFTVDLSHTATARTDASAMIDRMGERLAHIHLADGNGSAKDEHLVPGRGTQPCAELLTGLARSSFDGHIVIEVNTRRAMSSAEREADLAEALAFTRRHLAVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITV0</accession>
    <name>A0A0F4ITV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001125">
        <property type="protein sequence ID" value="KJY25074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951418.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001125.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5679"/>
    <dbReference type="EnsemblBacteria" id="KJY25074">
        <property type="protein sequence ID" value="KJY25074"/>
        <property type="gene ID" value="VR44_33555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3593"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="31069" checksum="5E8580E69B89FAB6" modified="2015-06-24" version="1">MLRLGRREFDTHEPVIMAIVNRTPDSFYDQGATFRDEPALDRVEQAVAEGAAIIDIGGVKAGPGEHVDAAEEARRTVGFVAEVRRRHPDVVISVDTWRHEVGEAVCAAGADLLNDAWGGVDPKLAEVAARHGAGIVCTHAGGVEPRTRPHRTAYEDVMEDILRVTVGLAERAEALGVPRESILIDPGHDFGKNTRHSLEATRRLAEMAETGWPVLVSLSNKDFVGETLDKPVKERLLGTLATTAVSAWLGAQVYRVHEVAETKQVLDMVRSIQGHRPPAVARRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITV1</accession>
    <name>A0A0F4ITV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">VR44_32535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="JZWV01001075">
        <property type="protein sequence ID" value="KJY25422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042817356.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001075.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7170"/>
    <dbReference type="EnsemblBacteria" id="KJY25422">
        <property type="protein sequence ID" value="KJY25422"/>
        <property type="gene ID" value="VR44_32535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3319"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY25422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="16845" checksum="DF95E3C808E7BC80" modified="2015-06-24" version="1">MSGKGAPVLSVKNCGDLRVAVIAAQWHEKVMDGLVDGALRALHELGIDEPTLLRVPGSFELPVVAKVLAGRGYDAIVALGVVIRGGTPHFDYVCQGVTQGLVQVSIDTGVPVGFGVLTCDNDEQALDRAGLEGSNEDKGHEAVTAAVSTAMTLRTVSEPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITV8</accession>
    <name>A0A0F4ITV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Bacterioferritin</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_33465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the bacterioferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01001123">
        <property type="protein sequence ID" value="KJY25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951402.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001123.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5153"/>
    <dbReference type="EnsemblBacteria" id="KJY25084">
        <property type="protein sequence ID" value="KJY25084"/>
        <property type="gene ID" value="VR44_33465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3573"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="158" mass="18559" checksum="CAE23C52B8C6FE5A" modified="2015-06-24" version="1">MQGDPEVLEFLNEQLTGELTAINQYWLHYRIQDNKGWTKLAKYTREESIDEMKHADKLTERILMLDGLPNYQRLFHVRVGQTITEMFQADRQVEVEAIDRLKRGIEVMRGKGDIPSARLFEEILEDEEHHIDYLDTQLELIESLGEALYIAQLIEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUZ0</accession>
    <name>A0A0F4IUZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_31470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001019">
        <property type="protein sequence ID" value="KJY25837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951028.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25837">
        <property type="protein sequence ID" value="KJY25837"/>
        <property type="gene ID" value="VR44_31470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2787"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="10761" checksum="F39AD5BC8E21E844" modified="2015-06-24" version="1">MNWLLLVAAGLVEVAWSQSIKPTAGFTRPLPTLLCFALAAVAVYLLSLAMKGLPVGTAYAVFTGIGAAGAITLGAVVHKDPVTPGRLLALALIIGGVALSHATAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV91</accession>
    <name>A0A0F4IV91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001009">
        <property type="protein sequence ID" value="KJY25930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25930">
        <property type="protein sequence ID" value="KJY25930"/>
        <property type="gene ID" value="VR44_31215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2730"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="82" mass="8725" checksum="F99A09E19A2E7A1C" modified="2015-06-24" version="1" fragment="single">PQPPTDEDPGTSQPPTDEDPGTSQPPTDQDTGTPGPPTDGGDTAGSARPCPVVDGWYDMTREFNAYYARHRTCLLYTSLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW88</accession>
    <name>A0A0F4IW88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonspecific lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_30345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000955">
        <property type="protein sequence ID" value="KJY26310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950824.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000955.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26310">
        <property type="protein sequence ID" value="KJY26310"/>
        <property type="gene ID" value="VR44_30345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2481"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="41206" checksum="3D285FB103468DCF" modified="2015-06-24" version="1">MKSYIVGVGMTKFEKPESRDWQYWDMVREAGGAALADAGVDYGLVEQVPVGYCFQPSTAGQRAAYELGLTGVPVYNVNNNCATGSTALMMARQFVQGGISDCVLAVGFEKMKRGALGGGADGGDFETSPVARHYGIMAAAHGFEMSPPTAQIFGNAAREHMERYGTTPAQLAAVGAKNHRHSANNPNAQFQDVYTVEEVLAAKTIHDPLTKLQCSPTSDGAAAALVVSERFVVAHGLHDKAVEIVAQAMTTDTAESFGGSCIDVVGKPMTAAAARRVYEDSGLGIEDVDVVELHDCFSVNELLTYEALGMCADGASGKLVESGATTYGGRWVVNPSGGLISKGHPLGATGLAQAAELVWQLRGEAGARQVPTARVGLAHNIGLGGAAVVTLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWB3</accession>
    <name>A0A0F4IWB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01001143">
        <property type="protein sequence ID" value="KJY24951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951471.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001143.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000055_gene598"/>
    <dbReference type="EnsemblBacteria" id="KJY24951">
        <property type="protein sequence ID" value="KJY24951"/>
        <property type="gene ID" value="VR44_33860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3696"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="110"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="658" mass="71992" checksum="424CD189B23C0951" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWJ2</accession>
    <name>A0A0F4IWJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001019">
        <property type="protein sequence ID" value="KJY25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951029.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25838">
        <property type="protein sequence ID" value="KJY25838"/>
        <property type="gene ID" value="VR44_31475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2788"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="186" mass="20036" checksum="BA7C4165E0D066E7" modified="2015-06-24" version="1">METRERADAARNRAKVLSAAAELFAAGDPRAVTMDDIARTAGIGRGTLYRRYPDVTSIAAALLDEHERRLQEELLRGAPPLGPGAPPHERLTAFYAAMVDLLESHGHLVLGAETGEKRFTIGAYGFWRAHVLALLRQSGTPDPDALVDSLLAPLAPEVFLQQRAQGVTPDRIKAALARLASVLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWL2</accession>
    <name>A0A0F4IWL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000995">
        <property type="protein sequence ID" value="KJY26014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26014">
        <property type="protein sequence ID" value="KJY26014"/>
        <property type="gene ID" value="VR44_31045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2662"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470328" description="Thioredoxin-like_fold domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="24926" checksum="DB25EABD4B1DEA77" modified="2015-06-24" version="1">MRAEHIHRVLVAVALLGLTMTACGDQTNAAQRARRHPYAGIEELPEALAPDGTTIVVGDPQRMPVHLYEDMRRPVCKEVEVTGAGGSLLEMTLGKEVRTEYTLSSASDGQLGGTGSKKAVNALRAALEQGKFAEYRAVLLRNQPEENGDGYTDALLLETASRVEGLRGPAFDSAVREMKYADFVEASQKAYEAVGAPVAPAADINGKRLPETESDVLLTKDVLSVWIDGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXD1</accession>
    <name>A0A0F4IXD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000912">
        <property type="protein sequence ID" value="KJY26667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950671.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000912.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26667">
        <property type="protein sequence ID" value="KJY26667"/>
        <property type="gene ID" value="VR44_29500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2268"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="213"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="331" mass="36189" checksum="5CFECD22323EDEC9" modified="2015-06-24" version="1">MPVTRSTLALPPGERADYWHELVSGTFIPLDVRLHEPVPSAGTITSRRLGPLQISEVEAGPQTVDRSTRRIAQGGEEYLTVTLQQRGSARLTQEGRQAVAGPGTFTCSDAGRPYRREQPDAFRFTAFRVPKAALGLPDADLRTATGTLFDGACGTSALVAAFLGRLAEQAAGFEPDTAHRLALTTSDLLAVLFRERGGRLDPQAPEHAHGMLTRVQEYVLLHLGDPALGPERIAAAHHMSVRYLHKLFRTGGTTVGRWILRERLERCRRELARPARAVPTVAAVAQRWGFVSPSHFSRAFRAAYGMTPREWQAAARLRPAVTPGPADRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXD5</accession>
    <name>A0A0F4IXD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_32755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001089">
        <property type="protein sequence ID" value="KJY25341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951267.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25341">
        <property type="protein sequence ID" value="KJY25341"/>
        <property type="gene ID" value="VR44_32755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3363"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="236"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="39046" checksum="641EE9F09335C7E4" modified="2015-06-24" version="1">MTARPPRPGRPAPRAPIDLLYSGTEEELRAAVRSLLTDRCDPAGVLARAETGRPHDPELWHTLAAEIGAAGLLVPEKLGGAGAGHREAAVVLEELGRAVAPVPYLTGSVLATEILLACACDGPEAAELLRELAAGRIVCVPALPLTLAPGAPLPAPLHDAGGGVLSGTVSSVADAVAADVLLVLADTGLHAVPADRAALDPVVPLDLTRPLATVTLDAATGTRLADPATARAAVAGALLSGAGLLASEQLGLAEWCLTETVAYLRGRHQFNRPVGSFQALKHRLARLWLDVASARAAARAAADALATAAPEAPLTVAVAQAYCSGVAVRAAEECVQLHGGIGMTWEHPAHLYLKRAKADSLALGTEGHHRGLVADFAELPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ12</accession>
    <name>A0A0F4IZ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_29395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950650.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000909.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26713">
        <property type="protein sequence ID" value="KJY26713"/>
        <property type="gene ID" value="VR44_29395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2243"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="DUF4188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="172" mass="19614" checksum="2B9D90A883DBF1CE" modified="2015-06-24" version="1">MSAKPIPGRTTAALEGDAVVLLIGMRINHFWAVHSWLPVFTGMPRMLRELKKDRARGLLNHVLLTASPRTYYVVQYWESKEKLYAYAKAPDALHHRMWAAINRKERAGRMRGHVGIWHETYVAPQGGYETIYFDMPPYGLAAATGVLPLEERGRRGADRFAYRPAAPQEPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J049</accession>
    <name>A0A0F4J049_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000853">
        <property type="protein sequence ID" value="KJY27274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27274">
        <property type="protein sequence ID" value="KJY27274"/>
        <property type="gene ID" value="VR44_28000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1851"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="10078" checksum="905970DC5D27D8FF" modified="2015-06-24" version="1">MPSARNIPWSKNANDDGTFKSDEELTALYEAEQVDLAKDTIAYCRIGERSALTWFVLHELLGQENVKNYDGSWTEYGSLVGVPIELGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0J9</accession>
    <name>A0A0F4J0J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_30095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000941">
        <property type="protein sequence ID" value="KJY26421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950779.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000941.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7076"/>
    <dbReference type="EnsemblBacteria" id="KJY26421">
        <property type="protein sequence ID" value="KJY26421"/>
        <property type="gene ID" value="VR44_30095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2422"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="29928" checksum="18E5B264D3F18207" modified="2015-06-24" version="1">MNAVRRLAGSVLLRVFLVLAALFWLVPTLGLLVSSFLSPGDLNRGGWWQALTAPSRLTASNYAHLLANDTITGSLVSTVAIAVPATVLVLTLGALAGYAFAWLEFPGRDWLFLVVVGLLVVPVQVALIPVSELFGAIGLFETTAGVVLFHTAFGLPFAVFLLRNFFAEIPRELLEAARLDGAGELRLFSRVVLPLGGPAIASLGIFQFLWVWNDMLVALVFADSAHPPVTVALQQQVRQFGNNIDVLAPGAFLSMVVPLVVFFAFQRQFVTGVMAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0L5</accession>
    <name>A0A0F4J0L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_30050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000939">
        <property type="protein sequence ID" value="KJY26441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950771.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000939.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26441">
        <property type="protein sequence ID" value="KJY26441"/>
        <property type="gene ID" value="VR44_30050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2394"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23405" checksum="1703D422179BF278" modified="2015-06-24" version="1">MTIRVVIADDQDMVRTGFRMILESQPDIEVVADAPDGQAALDAVAAHHPDVLLLDIRMPRVDGLEVTRRLSGQDTPRIVIVTTFDLDEYVHAALHGGACGFLLKDASPAMLVEAVRAAAAGDALVSPAITVRLLREMAPRMAGPQAARRPSEPLTEREQDVVRCLARGLTNAEIAADLYVSLSTVKSHLANVQAKLTARNRVEIAAWAWESGLATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Q3</accession>
    <name>A0A0F4J0Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27862">
        <property type="protein sequence ID" value="KJY27862"/>
        <property type="gene ID" value="VR44_26585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1442"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="60"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="203" mass="21342" checksum="602957FFD95FB657" modified="2015-06-24" version="1">MAASLLLPLTGCTTGDGAPREAGDGSPVVVAPGRPGEESRTLSPGQAARQRPDDSPNAADRAYVRRMIEHHRQALTMSALAPERASSDGVKRLAERIAAAQGPEIGAMEKWQARYPAPAGAPAGHDHGAMPGMATEQQLRELTQAHGADFDRLFLQLMTAHHEGALTMAGEALAQGNNGAVEEMANEVVAVQSAEIHRMRAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1W2</accession>
    <name>A0A0F4J1W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_25795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000747">
        <property type="protein sequence ID" value="KJY28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949989.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000747.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28265">
        <property type="protein sequence ID" value="KJY28265"/>
        <property type="gene ID" value="VR44_25795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1263"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045977">
        <property type="entry name" value="DUF5933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19356">
        <property type="entry name" value="DUF5933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5933" evidence="7">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="147"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="420" mass="45585" checksum="7CD71582E447FD0D" modified="2015-06-24" version="1">MIGLGFLVGLEIAARHYGTPGPITTQAREVIFPPKSGTVLYAAMTLMLVVLTWRQRFLAVGAAVGIDLLFWLVRWAAGAPTMFGNGALIVTLTCAVIAVTRRTGRERALLLKGVGLALLLVAGRKTGYTWLDITAQTRPMVLDQYVATADHALGNPSWVAGRIVQATGAIGADVLEWVYIQLAVGAVVVALYQLRGVAAERRFPRHHLVRTFLVIGLLGPGIYMVFPVVGPIFAYGADGAQWALADLWPHTPPPLDTPRAMIFDGSTPRNCMPSLHTAWATAIFIHSRKGPRALRFLGAFWLVATLGATLGFGYHYGADILAGVVFTLTIEIALRALDRGRDRRGLLLAGYGTAVFTALLLSYRFLSQELAALPWLCGPLLVLATASVVYGYVRTTRLWEREAGRLAVPEPRREPQPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1W3</accession>
    <name>A0A0F4J1W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27854">
        <property type="protein sequence ID" value="KJY27854"/>
        <property type="gene ID" value="VR44_26565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1438"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="14159" checksum="57BF252417A05BEE" modified="2015-06-24" version="1" fragment="single">PLFFRISATDWLEEDGWTADETVRLAALLQEHGVDLLDVSTGGLAPRVKIPTGPGYQVPFAARVKAETTLPVAAVGLITEPEQAEKILANGEADAVLLGRELLRDPYWARRAAAELGAEPRIPGQYQRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J204</accession>
    <name>A0A0F4J204_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000786">
        <property type="protein sequence ID" value="KJY27899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950121.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000786.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27899">
        <property type="protein sequence ID" value="KJY27899"/>
        <property type="gene ID" value="VR44_26500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1484"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="36467" checksum="C63AD60FB16421D0" modified="2015-06-24" version="1">MDGAHSTDHGGGHRAYIGSFTSGGGRGVLTAAVDPATGALTPLSTEGSLPDPSYLALDPATGVLYAVSETERGAAGAFRPTAEGLAPLGTPVPVGGSGPTHLSLAGRRLLTANYTSGSVSSLPLAADGSLRGPAAVLEYEGSGPDPDRQAGPHAHQVLPDPAGRWVLGVDLGTDAVRVCAPDPADGRLRVHARVALRAGSGPRHLAFHPAGAVVYVLHELEPLLTVCRWNADAGRLDPLAEVPVAPEGAPEGVRAFPSAITVSPDGRFLWAAVRGADALVTFSLAGGPEEPRPTGTVGCGGHWPRDLAADPSGRRLYAANERSGDVTWFEVDPRTGHPARTGSLPVPAASCVVFGGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J271</accession>
    <name>A0A0F4J271_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000792">
        <property type="protein sequence ID" value="KJY27848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950150.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000792.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27848">
        <property type="protein sequence ID" value="KJY27848"/>
        <property type="gene ID" value="VR44_26645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1454"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="22033" checksum="FCF7D0EA06D29E2E" modified="2015-06-24" version="1">MQLIQQNPDIHAYLASSEAIDHWHPLVQETADALWNSTGDAYSYAEAAFEFVRDTIPHSADSGDMRVSWRASDVLSTRNGICYAKSHALVALLRAQGIPAGLCYQLLGDDDGFNLVLHGLVALRLPGREEWSRVDPRGNKPGVDARFSLDVERLAFPVRPELGEIDHPGLYDAPHPATLKALQESADRPELWRNLPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2H7</accession>
    <name>A0A0F4J2H7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000724">
        <property type="protein sequence ID" value="KJY28502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28502">
        <property type="protein sequence ID" value="KJY28502"/>
        <property type="gene ID" value="VR44_25210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="23209" checksum="83E521696E93BD2B" modified="2015-06-24" version="1" fragment="single">MPVLAVVFDRGSAGSVEILASARKLCSVVFVCDEDLPGSAGAAARLAEVARVLDVTGLSPGQRHAALRALDPDGITTFSEYRLAATAELAQACGLTFHPPHVAAVLVDKERQRTRLREAGVQSTRCVAVRTAAQVPAALAEVGLPAVVKPRSGAGSVDTCRVDSAGQAMAVAEEFLAGGGAEFVLEEYLEGDPDAAGPGFGDYVSVESVSSGGAVRHVCVTGKLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2T3</accession>
    <name>A0A0F4J2T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_24930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000713">
        <property type="protein sequence ID" value="KJY28642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949827.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000713.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000036_gene7567"/>
    <dbReference type="EnsemblBacteria" id="KJY28642">
        <property type="protein sequence ID" value="KJY28642"/>
        <property type="gene ID" value="VR44_24930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.986"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="23614" checksum="3319A0EAA5B41614" modified="2015-06-24" version="1">MFDFLESGQYDLLGAFWVTVQLTLYSAVGSLVWGTVLAGMRVSPVPLMRAFGTAYVNLVRNTPLTLLVIGSSLGLSQTLGINLGGGTFKETGFRLAVLALTAYTGTFVCEALRSGINTVPVGQAEAARALGLSFFQVLTLIVLPQAFRAVIAPLANVLIALTKNTTVAAAIGVAEAALLMKEMIENEADALFAVFGIFALGFCLLTLPTGLLLGWVAKRVAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3K6</accession>
    <name>A0A0F4J3K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000744">
        <property type="protein sequence ID" value="KJY28293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949970.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000744.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28293">
        <property type="protein sequence ID" value="KJY28293"/>
        <property type="gene ID" value="VR44_25695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1238"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="31393" checksum="30C175195C5F4448" modified="2015-06-24" version="1">MSHVAYELATQPESWERAAELAPAHRAVLPKPGERTAIVGCGTSYYMAQAAAALREEAGQGETDAFPASEFPRHRRYDRVVALTRSGTTTEVLDLLSGLREAGIPATAVVGDPDTPVAGLAGELVVLDFADERSVVQTRFATTALTLLRAHVGAHTPDVVADGRAALAGPLPAGLEARGQFTFLGRGWSVGLAHEAALKMREASLSWAEAYPAMEYRHGPVSVTGPGSVTWSLGGTPEGIAEQVLGTGAEWVDGGLDPLAELVRVHRLAVAVAAVRGLDPDAPRNLTRSVILTGAEGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4M5</accession>
    <name>A0A0F4J4M5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">VR44_24835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949807.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28668">
        <property type="protein sequence ID" value="KJY28668"/>
        <property type="gene ID" value="VR44_24835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.966"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY28668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="291" mass="30542" checksum="CC397B876CAFD9D3" modified="2015-06-24" version="1">MTHTTLPFLKGHGTENDFVIVPDPDNAVDLPPTAVAALCDRRAGIGADGVLHVVRSAAHPDAAHLADEAEWFMDYRNSDGSVAEMCGNGVRVFARYLHHAGHVEPGDFAVATRGGVKQVHLAKTGDVTVSMGRARLPEGEVTVSVGERSWPALNVNMGNPHAVAFVESLDHAGDLYSPPPFSPASAYPTGVNVEFVVDRGPRHVAMRVHERGSGETRSCGTGACAVAVAAIRRDGADPAVTGEPVSYTVDLPGGTLVITEHPDGRIDMTGPAVIVAAGEFEADWLTETAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4Q1</accession>
    <name>A0A0F4J4Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transporter AzlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949505.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000652.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29342">
        <property type="protein sequence ID" value="KJY29342"/>
        <property type="gene ID" value="VR44_23190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.578"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="102" mass="10079" checksum="315A2F347B1D5614" modified="2015-06-24" version="1">MNVWIAIGLTAAGCYAVKLAGLLVPAGALERPAVRRLSALLPVALLAALTAQQTFSTGHDLVLDARAAGLAAAAVALLLRAPFLVVVGAAVVVTAGVRALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J545</accession>
    <name>A0A0F4J545_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000693">
        <property type="protein sequence ID" value="KJY28929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949681.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000693.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28929">
        <property type="protein sequence ID" value="KJY28929"/>
        <property type="gene ID" value="VR44_24120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.818"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="185" mass="19238" checksum="B2B9E20E23B587D3" modified="2015-06-24" version="1">MRYRYATEADAPALARLFAANHHDALTEEQRSAQGFVQGTFDAATLRDMAAAGELLVADDGRGRIAGLLALSVAADMADPPAAVTGLLRAQTGLAWHGRPLGEVPWLLYGPVVVDAAFRGHGVARGLFAMAVEASAGRAEALVAFIEAGNAPSWRVHVDAFGMTPLGDYTVAGRTYHAVATPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J581</accession>
    <name>A0A0F4J581_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000766">
        <property type="protein sequence ID" value="KJY28071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950057.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000766.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000058_gene2286"/>
    <dbReference type="EnsemblBacteria" id="KJY28071">
        <property type="protein sequence ID" value="KJY28071"/>
        <property type="gene ID" value="VR44_26155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1387"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="16380" checksum="471CC30ADC9AE4D7" modified="2015-06-24" version="1">MHGSEDQEFLALERELSVFLRRARASSGEMARALHPELEPAAYGLLVRLEAAGRQRATELAAYFGVGKATMSRQLRALEVLGLVAREPDPADGRAFLVGLTDEGRERFLRVRGARREQYMRKLADWDRGEVAELARLLNQLNSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5C7</accession>
    <name>A0A0F4J5C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxycytidine triphosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29420">
        <property type="protein sequence ID" value="KJY29420"/>
        <property type="gene ID" value="VR44_22940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.525"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="56" mass="6038" checksum="D5D4406FBE47E08D" modified="2015-06-24" version="1" fragment="single">LTPTRPVRVYAGMKIGQIMFFVSEGAIDLYSGKYQASAGPQPSAYWRDLGPSAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J669</accession>
    <name>A0A0F4J669_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949260.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29857">
        <property type="protein sequence ID" value="KJY29857"/>
        <property type="gene ID" value="VR44_21840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.247"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14548" checksum="DF967CBD99F776FB" modified="2015-06-24" version="1">MKPIGYWLNRTDQALTATMDALLAAFGLTRLAWQVLKVIEDDPRATDTVVRAVLAANAGAEELTAAIEAVLAGGWAFRPQPEGLALTDDGRVRLAEAGVRVAAFRERSTAGISVEEYRTAVAVLERMTHNLERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6J3</accession>
    <name>A0A0F4J6J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000612">
        <property type="protein sequence ID" value="KJY29830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949280.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000612.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29830">
        <property type="protein sequence ID" value="KJY29830"/>
        <property type="gene ID" value="VR44_21945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.268"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470170" evidence="1">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="9344" checksum="CADD730BF6D2770E" modified="2015-06-24" version="1">MTKTQRILAAFALAGAAAGLAAPAASAAPAAPLTLPDLPQAAPGMPAGAMPGSVQDIGAKVSEGANQLNQLMTLPDQLQPVIAPVAPLVDLLGAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6M0</accession>
    <name>A0A0F4J6M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY30002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30002">
        <property type="protein sequence ID" value="KJY30002"/>
        <property type="gene ID" value="VR44_21465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.171"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023893543" evidence="2">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26727" checksum="A1EAA3C6D1E3F61B" modified="2015-06-24" version="1">MFAAVCVLLAATGHILMSGVAVPWWAVPPAFAGTIAAAWALADRERGPLAVTTATVAVQAVLHAGFSLAQSLTHPSLPAGNSFARQWAAYLTCGGGTGTGLSAHEALKTVNEAGLATFMSRLPPGAPMTDAHDMHGMHGMHAMHGMASPTGGIGMPATGHDMAGMSPTGMLAAHLLAAVLCGLWLACAEQATFRCLRAVAGWLRAPLWVLFRLLTPTTPHLPRVRVRRSRRRHALRQLLLVHAITSRGPPTGTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6S6</accession>
    <name>A0A0F4J6S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000641">
        <property type="protein sequence ID" value="KJY29458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949456.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000641.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29458">
        <property type="protein sequence ID" value="KJY29458"/>
        <property type="gene ID" value="VR44_22900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.514"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6540" checksum="B23ACB7968337081" modified="2015-06-24" version="1">MNRITESVRGIADAALSEDTGERTSRMMPVAFTPAVLVVCPYAAGGLAAGAAAVGAYEAGRAAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6X5</accession>
    <name>A0A0F4J6X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000603">
        <property type="protein sequence ID" value="KJY29940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29940">
        <property type="protein sequence ID" value="KJY29940"/>
        <property type="gene ID" value="VR44_21590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.195"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="239" mass="25442" checksum="D2FEA5EABA71F8E4" modified="2015-06-24" version="1">MWDPHARRLAPRFRITAPDLPGHGSLRGRPFRLEEAVAQVAVAVAEAARVTGRRPVVAGSSLGGYVTLAYGAAHPDAAAALLVQGATARPDGATGLVYRAAARAFDALGPQRAARLNDRAFRRRLPAESYEAVMRGGLAMPAFGEVVDELARYDFLGLAGRCRLPVLFVNGLGDRLFRTREREFLAAARSGGGRARLFHVHGPHIMSLTDPAAFTRTLERGHALLVPAARDRAAGGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Y9</accession>
    <name>A0A0F4J6Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_24765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000708">
        <property type="protein sequence ID" value="KJY28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28696">
        <property type="protein sequence ID" value="KJY28696"/>
        <property type="gene ID" value="VR44_24765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.954"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="98"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="612" mass="61754" checksum="8E18C9135B0486BC" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J790</accession>
    <name>A0A0F4J790_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable subtilase-type protease inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sti</name>
        <name evidence="11" type="ORF">VR44_20880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Strong inhibitor of bacterial serine proteases such as subtilisin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000580">
        <property type="protein sequence ID" value="KJY30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30252">
        <property type="protein sequence ID" value="KJY30252"/>
        <property type="gene ID" value="VR44_20880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8906"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00778">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8 9" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8 9" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="8">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13031" checksum="D3CB196B5D4FBD80" modified="2015-06-24" version="1">MCLAGATGMAEAKPTSLYAPSAMVFSIAQGDDAAGATVLRAATLSCMPSAQGTHPDPKAACTALNSTGGSFDRLLAAPDVNRACPMHYAPVTVTADGVWQGSRVSWKHTFSNSCDMSATLNGGAVFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7M3</accession>
    <name>A0A0F4J7M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000693">
        <property type="protein sequence ID" value="KJY28926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949678.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000693.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28926">
        <property type="protein sequence ID" value="KJY28926"/>
        <property type="gene ID" value="VR44_24130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.820"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6885" checksum="5A8340BB3754B79C" modified="2015-06-24" version="1">MESETNEQPTRSDRLFTGGERPYDPEDLVMATGHDPTPERVEAARKLIAEKGPSVIERYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N0</accession>
    <name>A0A0F4J7N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor SigD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_20550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949017.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1087"/>
    <dbReference type="EnsemblBacteria" id="KJY30407">
        <property type="protein sequence ID" value="KJY30407"/>
        <property type="gene ID" value="VR44_20550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8821"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY30407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22413" checksum="DE9C0DD2CFB712FD" modified="2015-06-24" version="1">MRDDEALGSPPAAGPTGAAKGGNAGAVSALVRRAVDGDEQATHDLLAFVHPLALRYCRTRLSRLPGDARHFVEDLAQEVCVAVLMALPRYRDTGRPFEAFVFAIAAHKVADLQRAAMRHPGSTAVPSDEMPERPDDSLGPEERALLSSDAAWAKKLLANLPENQRELLVLRVAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8E4</accession>
    <name>A0A0F4J8E4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000548">
        <property type="protein sequence ID" value="KJY30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948897.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000548.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3100"/>
    <dbReference type="EnsemblBacteria" id="KJY30667">
        <property type="protein sequence ID" value="KJY30667"/>
        <property type="gene ID" value="VR44_19895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8598"/>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20901" checksum="3A8A8673D938EECA" modified="2015-06-24" version="1">MVNLTRIYTRTGDQGTTALGDMSRTRKTDLRISAYADANEANAAIGTAIALGSLPEEVVKVLVRVQNDLFDVGADLCTPVVEDPQYPPLRVEQFYIDRLEADCDVFNERLEKLRSFILPGGTPGAALLHQACTVVRRAERSTWAALEAHGEVMNPLTATYLNRLSDLLFILARTANKELGDVLWVPGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8I8</accession>
    <name>A0A0F4J8I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30063">
        <property type="protein sequence ID" value="KJY30063"/>
        <property type="gene ID" value="VR44_21295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8984"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22642" checksum="F4027A3D8F655033" modified="2015-06-24" version="1" fragment="single">MAREFQRGHKARISDLTAGTDLYVGVQIAGPGLTFDISCFGLDADERLSDDRYFVFYNQPKSPEESIQQLGAQAGDTESFRVTLDHVPASIHKLSFTATLDGDGQMSQIGPGYIRIVAGGEEVVRYSFTGAEFSTERALMIGDFYRKDVWRFAAVGQGFDGGLAALLEHFGGEVAEDEPQPQQAPAQPQAAAPGFAPPPQAAAPPAPTPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J901</accession>
    <name>A0A0F4J901_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000548">
        <property type="protein sequence ID" value="KJY30665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30665">
        <property type="protein sequence ID" value="KJY30665"/>
        <property type="gene ID" value="VR44_19885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8596"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41924" checksum="5060A2F312C97D78" modified="2015-06-24" version="1">MTPAIPRPHRDDVLIAVISTLFGLLLWSLGVHSTGPGGTGYRHHLPVWAALVPMLAVGGMELLRRTAPRLTLAVGTLAVIADQFTVGSIATVVMFTDLMYAAVVYGTPSMARRLPVSTGLITLVVTIGTLAWLRSPQALMVGVLTGIVSFAPALTGATLRNHREAAEAARLRAEQTALLAEADRAQAVAAERARMARELHDMVANHLSAIAIHSTAALSIDSPSTSREALGVIRENSVQGLAEMRRLIGLLREAGAGQEAAPVPSLDGLEALLGQARTNGAASGLDFVLDDARPAGRPPLPAPVELAGYRIVQESLTNALKHAAPGTVTVRLARRDGRLTVVVDSPYGDRPGPRAPGSGAGLIGMHERAELLGGTFTAGPQGPVWQVRAELPAEDKAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J926</accession>
    <name>A0A0F4J926_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000574">
        <property type="protein sequence ID" value="KJY30309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30309">
        <property type="protein sequence ID" value="KJY30309"/>
        <property type="gene ID" value="VR44_20800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8879"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470501" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14893" checksum="A4211B90672194CC" modified="2015-06-24" version="1">MFLALSVTAALFTPSMPAQAASLYGIKAVTIAASKKGAPYVYGATGPAEFDCSGLTLYAFRQAGRVLPRTAEAQYESTDHISRTQRAPGDLVFFPTGGTMSHVGIYAGHDKIWHAPRPGTRVRLERIWTGTARYSRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9T8</accession>
    <name>A0A0F4J9T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948781.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30950">
        <property type="protein sequence ID" value="KJY30950"/>
        <property type="gene ID" value="VR44_19250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8456"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18500" checksum="431C3CCB210E676D" modified="2015-06-24" version="1">MSNETKTTELAPEHTPRMQLFKLAPEAYKAAVALDAAANKGLDPAIAELVKIRASQINHCAFCLDMHTKDALAAGESVERIIQLSAWEESKHFYTEKELAAIELTEAITVLTDGFVPDEVYEKAAKHFEEAELAQLITAIAMINMWNRFAVTTRLSPGHYTPGSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA32</accession>
    <name>A0A0F4JA32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000509">
        <property type="protein sequence ID" value="KJY31227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948658.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000509.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31227">
        <property type="protein sequence ID" value="KJY31227"/>
        <property type="gene ID" value="VR44_18600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8316"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="322"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1123" mass="121953" checksum="59171EA9E0D13D75" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JB06</accession>
    <name>A0A0F4JB06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000526">
        <property type="protein sequence ID" value="KJY30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5447"/>
    <dbReference type="EnsemblBacteria" id="KJY30969">
        <property type="protein sequence ID" value="KJY30969"/>
        <property type="gene ID" value="VR44_19175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8441"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="28283" checksum="8E90568B7187A37F" modified="2015-06-24" version="1">MRSDTVTDQKAPKSEQTRTLILETALRLFQERGFDKTTMRAIAKEAGVSVGNAYYYYESKEHLVQGFYDRISAAHQAAVRPILDQETDLQKRLAGVLTSWLDIAAPYHEFASQFFKNAADPESPLSPFSPESEPARQAAIAIHREVLAGAKTKVPAELADLLPELMWLSQMGLVLYWVFDRSPESEKTRRLAERGAQLTTRGIVLARFRVLRPLVRELHELFADFLPGMAQTAVSRGGKRASDPAKAPEPEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBV9</accession>
    <name>A0A0F4JBV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007262890.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000563.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6647"/>
    <dbReference type="EnsemblBacteria" id="KJY30441">
        <property type="protein sequence ID" value="KJY30441"/>
        <property type="gene ID" value="VR44_20455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8801"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="17028" checksum="3E84777C8AB39F3B" modified="2015-06-24" version="1">MNELDVVGVRVEMPSNQPIVLLREVGGDRYLPIWIGPGEATAIAFAQQGMAPARPLTHDLFKDVLEAVGEELTEVRITDLREGVFYAELVFASGVEVSARPSDAIALALRTGTPIYGSDGVLDDAGIAIPDEQEDEVEKFREFLDQISPEDFGTGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE90</accession>
    <name>A0A0F4JE90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_16830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948323.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000445.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5414"/>
    <dbReference type="EnsemblBacteria" id="KJY32063">
        <property type="protein sequence ID" value="KJY32063"/>
        <property type="gene ID" value="VR44_16830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7801"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="134" mass="14190" checksum="FC9CE741AD7B3C0A" modified="2015-06-24" version="1">MGVTGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAIGLSILSGAHNTLFVRVLELLKERDAEDIKVFGGGIIPEDDIAPLKEKGVAAIFTPGATTTEIVDWVNANVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG07</accession>
    <name>A0A0F4JG07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">VR44_14220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="JZWV01000366">
        <property type="protein sequence ID" value="KJY33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947843.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000366.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3356"/>
    <dbReference type="EnsemblBacteria" id="KJY33277">
        <property type="protein sequence ID" value="KJY33277"/>
        <property type="gene ID" value="VR44_14220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7191"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15672" checksum="B715E56DB2CBFAE7" modified="2015-06-24" version="1">MSRPVLVLNGPNLGRLGSREPDVYGATSYAGLVESCRTLGAELGFDVEVRETNDEGELVRWLHEAADGKIPVVINPGAFTHYSYAMRDAAAQRTAPLIEVHISNPYAREEFRHTSVIAAVATGTVAGFGLGSYRLALRALAEEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGM7</accession>
    <name>A0A0F4JGM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32121">
        <property type="protein sequence ID" value="KJY32121"/>
        <property type="gene ID" value="VR44_16600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7752"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="TOBE_2" evidence="2">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="23180" checksum="A2A8425058F5A583" modified="2015-06-24" version="1" fragment="single">GDRYPHQMSGGQQQRVALARALALRPRVLLLDEPLSALDAKVRASLREEIRRLQLSLGITTVFVTHDQEEALSMADRVAVLNAGKLEQCAAPAELYERPATPFVAEFVGTMNRLPGRLAGSGRVDVAGTRLPVDGPVPAGPDVEVLVRPENLTVTADEEGGATVTSASFFGAVTRLHLDLPGGTRVKADVPSRDAGGLTPGARVTVGLAERPVLVVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH31</accession>
    <name>A0A0F4JH31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000374">
        <property type="protein sequence ID" value="KJY33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947901.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000374.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33114">
        <property type="protein sequence ID" value="KJY33114"/>
        <property type="gene ID" value="VR44_14560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7169"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="29198" checksum="E8E8DDCF2316D8DE" modified="2015-06-24" version="1">MADLITIEDPDDPRLRDYTGLTDVELRRRREPAEGLFIAEGEKVIRRAKDAGYEMRSMLLSAKWVDVMRDVIDEIPAPVYAVSPDLAERVTGYHVHRGALASMQRKPLPTAQELLASASRVAVMEAVNDHTNIGAIFRSAAALGMDAVLLSPDCADPLYRRSVKVSMGAVFSVPYARLEAWPKSLDTVREAGFKLLALTPHEKASPIDVAAPHTLERVALMLGAEGDGLSTQALVAADEWVRIPMAHGVDSLNVGAAAAVAFYAVAGGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHV9</accession>
    <name>A0A0F4JHV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000327">
        <property type="protein sequence ID" value="KJY33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33917">
        <property type="protein sequence ID" value="KJY33917"/>
        <property type="gene ID" value="VR44_12955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6708"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="15364" checksum="918306D2A8353814" modified="2015-06-24" version="1">MDAGTAAASASATAMFSGGHSAGNGVIPGMEKLYSFADGGAHRAVEDMRALVARCRTVELPHAAGEPADTAAFAIAEGPRLGDESLVVQAAVTGGGQGAAGGTQHADATVVRVGNALVVISSVLTLTPEEAGTVAGFMPTAVAQVVSDHPEPVGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ22</accession>
    <name>A0A0F4JJ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_13300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000338">
        <property type="protein sequence ID" value="KJY33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947676.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000338.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene697"/>
    <dbReference type="EnsemblBacteria" id="KJY33778">
        <property type="protein sequence ID" value="KJY33778"/>
        <property type="gene ID" value="VR44_13300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6882"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="62"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="172"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="283"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="649" mass="70930" checksum="237F016D1E894269" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ68</accession>
    <name>A0A0F4JJ68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947492.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34240">
        <property type="protein sequence ID" value="KJY34240"/>
        <property type="gene ID" value="VR44_12305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6445"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470601" evidence="2">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="14364" checksum="1EC2F9E06B726D92" modified="2015-06-24" version="1">MLANRRTAAAIGAVALAGALLSAGPAQADSASPSPSAPAKAAKQAPKGDGAKAICKRLPKTESRIGTALNRLNGDATVPGSIARLEQRVTEAKNAGHTEIQTYLNDRLTFRKSLVTTLQKRQEDLKAVSTWCTAQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ75</accession>
    <name>A0A0F4JJ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000291">
        <property type="protein sequence ID" value="KJY34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34402">
        <property type="protein sequence ID" value="KJY34402"/>
        <property type="gene ID" value="VR44_11940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6469"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470779" evidence="1">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="17827" checksum="87E95DCAD0BD0B42" modified="2015-06-24" version="1">MACAAVAACAVLTGCAAGAPDRAADPDEVIKAATQRLTDACLIRQGLVPPRSGGARQPGTEDARVSAALFGTGPAELSLALPTGYVVRAHTDGCLAAAQQRLYGDQPGWFRASVVVNNLRPEADHTHRDLAEVRARHRGEIADWQRLRAHALTEAETVLNTPPPKGNPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJF9</accession>
    <name>A0A0F4JJF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000294">
        <property type="protein sequence ID" value="KJY34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947447.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000294.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34345">
        <property type="protein sequence ID" value="KJY34345"/>
        <property type="gene ID" value="VR44_12080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6501"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19805" checksum="9D41650890C78C1C" modified="2015-06-24" version="1">MLRGAKVGLRARFDEDIPVLRTELYDDVVNSSRSEAGPWKPMTPGTRDPRLVVDEKQERSVSFSVVELEGGTLIGSATLWGIDTHNRNAHIGLGLFPAARGKGYGTDVVAVLCHYGFTVRGLRRLQIETLADNAAMLRSAERNGFVREGVLRSSAWVMGEFLDEVLLGLLAQDWEPAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKX1</accession>
    <name>A0A0F4JKX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34454">
        <property type="protein sequence ID" value="KJY34454"/>
        <property type="gene ID" value="VR44_11830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6371"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="26767" checksum="331C1947BC3C7525" modified="2015-06-24" version="1">MRAGGLVDLTGRSCLVTGAASGIGRATAALFARLGARVTAADLDTGGLTALRRDCADRGDAYEVTVVTGDVSRPEDAERMTGAAVAAGGGLDVLVANAGILPLSDLLETSAEDWDRVMAVDGRGMFLSCKYAIAQMARQEGGGTVVCVSSISGVAGQARQAAYGPAKFVASGLTKHLAVEWAGRRVRVNAVAPGTIRTERVRRLADEPGGPEYLDRVTGLHPLGRLGEPEEVARAIAFLASDAASFITGAVVPVDGGYLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLC0</accession>
    <name>A0A0F4JLC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000242">
        <property type="protein sequence ID" value="KJY35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947206.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000242.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35142">
        <property type="protein sequence ID" value="KJY35142"/>
        <property type="gene ID" value="VR44_10785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6007"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22615" checksum="AD973B09B6769CD6" modified="2015-06-24" version="1">MTFGFAPPATASLTTATGGASRHGRLLEPSEWTAAGVPLLRNPREVVSGLHSRHSPVPSTAVIAVLGPEERLVASASFVQRSASADGWEYRNALLSRLRRVIPHDLRRRTPVRTAVLMYCRDGDERWTEEDGAWMWGLRDACTLHGLRCGAYITLTRGGWQVLGEGRGGRHPSSESRPERLGSMTEVAPLPLSTAGGMVEPLRRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLC4</accession>
    <name>A0A0F4JLC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000241">
        <property type="protein sequence ID" value="KJY35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947205.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000241.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35147">
        <property type="protein sequence ID" value="KJY35147"/>
        <property type="gene ID" value="VR44_10770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5904"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="559" mass="59864" checksum="4DE4990C4E61BF33" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLD5</accession>
    <name>A0A0F4JLD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947247.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34990">
        <property type="protein sequence ID" value="KJY34990"/>
        <property type="gene ID" value="VR44_11015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6087"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="9175" checksum="6C94EA7EFE5DCC51" modified="2015-06-24" version="1">MSSCCSPDGACASNGETTTTVAVVDSTATVYRVSGMSCGHCRTAITASVGALAGVLSVDVDVDGGVVTVTTAGEPDDAAIAAAVDDAGYELTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLY3</accession>
    <name>A0A0F4JLY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947307.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34778">
        <property type="protein sequence ID" value="KJY34778"/>
        <property type="gene ID" value="VR44_11330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6161"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="459" mass="50774" checksum="A07D766B1B005EDE" modified="2015-06-24" version="1">MGQPTIPTAPGALPLLGHLIPLMRDPLAFMRSLPGHGDLVRIRLGPLSVVMACDPAAIRQVLRDDHTFDKGGFFYERAAEVGGQGLVTCPHTLHRTQRRMCQPAFRTARLPDHTTAMTAQADTASSGWHEGQTIDVPEEMMALAVRNLTATMFSDELPPQTLQHMPHDVDAIVAGFFGRLIMPGALSRLPLPATRRYEQALTRLRTTLAAVITDRRAHPGDQDDLLSRLLTRDPHHPATALTDEEITDQFITFFIAGAETVASTLSWALDLLTRHPDTLRDLRTEIDTALAGRPVTYDDFPRLPLTGRVITETLRLYPAGWIYTRTATTDTTLAGTPIPAGTTLAYSPYLLHHNPAVHPDPERFDPDRWLPERAKATSRDHYIPFGGGPRKCIGDQFALTEATTTLATIVQNWHLHPLTHCPVRTQRATPVHPRDLRLRLNRRTPTTQTSPPSHGTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMA4</accession>
    <name>A0A0F4JMA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_12690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000316">
        <property type="protein sequence ID" value="KJY34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene520"/>
    <dbReference type="EnsemblBacteria" id="KJY34071">
        <property type="protein sequence ID" value="KJY34071"/>
        <property type="gene ID" value="VR44_12690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6617"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23229" checksum="807E921F3137E78B" modified="2015-06-24" version="1" fragment="single">MGQVWTAYDKRLDRRVAVKLLRPDKVAGPGTVAEELRRRFVRECRVTAQVDHPGLVTVHDAGSDGDELYLVMGYVEGSDLADHLAAHDPYPWPWAVAVAAQLCAVLSAVHAVPIVHRDLKPRNVMIRPDGTVLVLDLGVASVMDTDTTRLTSTGSPIGSPAYMAPEQAMSGAVGPYTDLYALGVLLYELLSGDVPFAGSTALGVLHRHLYEPPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMG6</accession>
    <name>A0A0F4JMG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000214">
        <property type="protein sequence ID" value="KJY35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947054.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000214.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35547">
        <property type="protein sequence ID" value="KJY35547"/>
        <property type="gene ID" value="VR44_09950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5538"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="128" mass="13540" checksum="4BFB66822BB8F243" modified="2015-06-24" version="1">MRHLTLADVLGLARYACLAQDQPVELRAPGLLESAVHRPRARMYGTPAYTDLHEQAAALLHGIAVNHPLVDGNKRTAWLAAATFLAVNGADPAAADQDAAYALVVDVASGAEARVAVIADRLRELVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMS8</accession>
    <name>A0A0F4JMS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000303">
        <property type="protein sequence ID" value="KJY34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947488.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000303.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34256">
        <property type="protein sequence ID" value="KJY34256"/>
        <property type="gene ID" value="VR44_12270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6437"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="13687" checksum="C9ECD4D62D80C28F" modified="2015-06-24" version="1" fragment="single">MTSTKQFQVTFDCADPERVARFWCEVLGYVVPPPPKGFASWTEFDRSLPPERQGSAFACVDPSGVGPRLFFQRVPEGKAVKNRVHLDVRVGTGLVGEERVAALEAECARLVALGAVRVQLLRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JND7</accession>
    <name>A0A0F4JND7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35710">
        <property type="protein sequence ID" value="KJY35710"/>
        <property type="gene ID" value="VR44_09375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5203"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="21795" checksum="46677B2C83D4DCAC" modified="2015-06-24" version="1">MTTMTERARPIEPVEGERTFEDVLRAVEEMDTPDGYKAELIRGKIIVSPWSKLRYLRSMRALRQQLEQHAPEGHIAESSPFLFSFPAAGRAYGPDLYVADEAAFDADGRHADAAALSLVAEFTSVSPRDVDWEEKLQVYGQVVPVYLVVDAQGGEIACFSDPSPQGYRAHKTVSFGTPLPVPAPFDCKIDTTVFKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNT6</accession>
    <name>A0A0F4JNT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35489">
        <property type="protein sequence ID" value="KJY35489"/>
        <property type="gene ID" value="VR44_10110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5622"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="9239" checksum="A65C3CC1EFDD690E" modified="2015-06-24" version="1">MTEAERDEMVAAQGGLCCICLKAPAVHVDHCHETGRVRGVLCFNCNSAIGKLGDDPDTLRRAISYLEGHAWKPTIVAQGVYRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP43</accession>
    <name>A0A0F4JP43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947024.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3688"/>
    <dbReference type="EnsemblBacteria" id="KJY35614">
        <property type="protein sequence ID" value="KJY35614"/>
        <property type="gene ID" value="VR44_09785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5457"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="247" mass="27168" checksum="18307F3592D5B776" modified="2015-06-24" version="1">MAVEPLIELRDVNKHYGDLHVLQDINLTVGRGEVVVIIGPSGSGKSTLCRTINRLETIGSGEILLDGRPLPAEGKELAQLRAEVGMVFQSFNLFAHKTVLANVSLAQIKVRKRGREEADKRSRELLDRVGLASQAEKFPAQLSGGQQQRVAIARALAMNPKALLFDEPTSALDPEMINEVLEVMQQLAAEGMTMVVVTHEMGFARSAANRVVFMADGRIVEDRTPEAFFTAPESERARDFLSKILKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPB6</accession>
    <name>A0A0F4JPB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947305.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34776">
        <property type="protein sequence ID" value="KJY34776"/>
        <property type="gene ID" value="VR44_11320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6159"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="27571" checksum="516D49A44B8C8500" modified="2015-06-24" version="1">MPVTELWPSRTAHQVETALAAAAKELSALDARVEHYRVPRGGYAAWTGDTASEVFSLEARIGPAHHRPGISMWAVFQVFDPRRPNLALVRMLERHDADGAPVQDVRRPSYTLELDLRLCRVFMPACNRALNHLDPTGRGHSQHVDCYHGRVPPSHLLTAPVVAVDLFRRFRRDGQKAIILADFNDPLAVPTVSIVKHLLVRQGGHLIPRTRKPSAARVLLRRPDGSIQQLAGMSTAADEGIAIARRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPM4</accession>
    <name>A0A0F4JPM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="5" type="ORF">VR44_08195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000166">
        <property type="protein sequence ID" value="KJY36322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946729.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000115_gene2501"/>
    <dbReference type="EnsemblBacteria" id="KJY36322">
        <property type="protein sequence ID" value="KJY36322"/>
        <property type="gene ID" value="VR44_08195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4389"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="37001" checksum="27868A89B333C251" modified="2015-06-24" version="1">MSTSINLAVIPGDGIGQEVVAQGLKVLTAVLPQDVKLETKQYDLGAQRWHRTGETLPDAELEALKHHDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHFINLRPSKLFPNTATPLAGRPDIDFVVVREGTEGPYTGNGGSLRTGTPAEVATEVSVNTAYGVERVVRDAYERANSRPRKKLTLVHKNNVLVYAGHMWKNIFDKVGQEYPEVTTDYLHVDAATIFFVTQPERFDVIVTDNLFGDILTDLAAAVTGGIGLAASGNINPTGAFPSMFEPVHGSAPDIAGTGKADPTATILSVALLLRHLGYEEQAVRIEEAVSADLAERDGTFRSTDAIGDALAARVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPN1</accession>
    <name>A0A0F4JPN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946941.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35708">
        <property type="protein sequence ID" value="KJY35708"/>
        <property type="gene ID" value="VR44_09360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5200"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="15304" checksum="03F561CCD4622676" modified="2015-06-24" version="1">MGIKLSQCFIAVDDHDKAIPFYRDVLGLEVRNDVGYENMRWVTVGSPEQPDVEIVLEPPLADPNATPADRQAVAELLAKGMLRGVIFTTDDVDATFERIRAAGGDVLQEPMDQPYGVRDCAFRDPAGNMLRFNQPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQ43</accession>
    <name>A0A0F4JQ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000191">
        <property type="protein sequence ID" value="KJY35883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946871.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35883">
        <property type="protein sequence ID" value="KJY35883"/>
        <property type="gene ID" value="VR44_08960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4963"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="195"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="38383" checksum="F0EF1EC8051BE725" modified="2015-06-24" version="1">MTRPLRIALIASARFPIREPFAGGLEAHTWALAWALRRRGHHIALFAAPGSDPRLNVRELPVRAPRLSPAARADLSMSDPSALHEHHAYLSLMLDLARGDDGGPAYDLVHNNSLHYLPVAMAPAVPAPVVTTLHTPPTPWLESAIQTDPTGSGVFTAVSAHTARSWQPLVRSARVVHNGIDLRRWPAGPGGGDLVWYGRIVPEKGPALAIAVAAATGLPLTLAGPVADRRYFRDRVAPRLGGRIRYAGHLTRTELAALVGSARATLVTPCWDEPYGLVVAESLACGTPVAGFDRGALAEILTPDCGRLVPYPDVAALAAAVGETVKLSRRACRERARAFCSLSHMTDRYEALYAELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQE4</accession>
    <name>A0A0F4JQE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947193.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35156">
        <property type="protein sequence ID" value="KJY35156"/>
        <property type="gene ID" value="VR44_10720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5892"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="161" mass="16671" checksum="EDAC1B9479B1F9DD" modified="2015-06-24" version="1">MDRIVLTAATLYAIVLLRAGGTFAVGWLAGAGARRSRFAGRISSAKFQRAERAIQRWGAPVVAVSFLTVGLQTAVNFLAGSMRMPLPRYLPALFVGGAAWALIYATAGLGVLELLGGLFAGRTALGVSAVAVLLLALCAVVVFRRRRAASLSPGDGTAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQX1</accession>
    <name>A0A0F4JQX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946747.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36249">
        <property type="protein sequence ID" value="KJY36249"/>
        <property type="gene ID" value="VR44_08335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4566"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="295" mass="30705" checksum="1595ED9796D1316F" modified="2015-06-24" version="1">MTYSAPPALLSLALNLVEAHVPVLPLRKGKLPFGNCAACTGSACGDRPHMKAAGPCQCPAPCHGWAAATTSREVLASPAWAAAWRQAGAVAYHPGGAQLTVVDLDNANAVAWARLNLPPTKTVATMRGEHWIYQGAMASANRVRPGVDIKSRMQYTRWYGRGTGPITVLPDAVRALTAREEATPPRARVASSSGGRATWDRSVATGCRHTETFVRTGLDRGLAKVAACREQGAGSQAYGVARFLAAQHTACPGPCGLGTLAQQIIDAAVSVGVPQAYAERAVTNGFASAGLVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRY2</accession>
    <name>A0A0F4JRY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946640.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36594">
        <property type="protein sequence ID" value="KJY36594"/>
        <property type="gene ID" value="VR44_07735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4159"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="587" mass="63746" checksum="F35A85C76423167D" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSB5</accession>
    <name>A0A0F4JSB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000147">
        <property type="protein sequence ID" value="KJY36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946613.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000147.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36648">
        <property type="protein sequence ID" value="KJY36648"/>
        <property type="gene ID" value="VR44_07580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3993"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="40362" checksum="23A70FC4AAD63744" modified="2015-06-24" version="1">MNIQGVVTEGFEPVREAFARNFEVLGDRGAAVAVYRDGRKIVDLWGGTKDANGSEPWAEDTATIVRSATKGVAAAVPLLLHQRGLLDLDAPVSSYWPEFKAGGKERTLVRHLLAHQAGVPALDRGLTMAEAADGVTGARAVAAQQAFWEPGSAHGYHAQTFSWLVSELVLRATGRTVGGILAEELAEPLGLDFWIGLPEGEAHRVGRVAPVEPPPSAGLLKTRPRRNVSEAYADPESLTRRAFAAIDPQPDENDPVYQAAELPGSAGIGTARALARFYAATIGVVEDGARIFTPATTALAGTEFAAGPDRVLVVGTRFGPGYMLHGPASPLLSPASFGHPGRGGSLAFADPEAGIGFGYVTNAHAKSVTADPRAQALVRALRGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSJ0</accession>
    <name>A0A0F4JSJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000109">
        <property type="protein sequence ID" value="KJY37337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37337">
        <property type="protein sequence ID" value="KJY37337"/>
        <property type="gene ID" value="VR44_05915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6970" checksum="E41754D26BD46802" modified="2015-06-24" version="1">MPQRSQASGQPAEWSVACGWADCQAVMDLFQSSPVRAVREAGKAVLLALPVGEEDGLDGGEQGAGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT08</accession>
    <name>A0A0F4JT08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_05590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000104">
        <property type="protein sequence ID" value="KJY37487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2503"/>
    <dbReference type="EnsemblBacteria" id="KJY37487">
        <property type="protein sequence ID" value="KJY37487"/>
        <property type="gene ID" value="VR44_05590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9643" checksum="2B9D9705282FC650" modified="2015-06-24" version="1" fragment="single">MTEPLPAIVLIGHGMVGQRYLEALAERGATATHRVTVLCEEPRPAYDRVHLSSYFSGSSPEELSLTPAGFMAEHGIELHLGDPAESVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT11</accession>
    <name>A0A0F4JT11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946802.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36096">
        <property type="protein sequence ID" value="KJY36096"/>
        <property type="gene ID" value="VR44_08605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4863"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033434">
        <property type="entry name" value="MucB/RseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03888">
        <property type="entry name" value="MucB_RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470839" evidence="2">
        <location>
            <begin position="36"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MucB_RseB" evidence="3">
        <location>
            <begin position="108"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="41315" checksum="5C7E492ACEB0CD11" modified="2015-06-24" version="1">MAANTKTSRKAARYAVPVAVAGVAAATAAMVPAFATAGGPDLPKVTAQQLIEKVAASDVQQLSGSAKITTDLGLPTLATGLLGGAGVTGGSANPEDKIAQLAAGTHTLRVAADGPDRQKLTFLDGKDEYTLVHNGNDVWGYDSKSNEAFHDKGDRAGQDHKTGDRLAASPQQIAQDIIKQAGPTTDIGVGDTAQIAGRDAYQLVLKPKQSGSTVGSVQIAVDAKNGVPLRVQLLSSQGGKPIVEAGFTQVDFGKPAADSFTFTPPKGAKVTEGADKARGGKDAKGGKDDERFKALESLPGFGQLAGGDHGKGDVKVLGEGWATVARIDSGAGKSLKDVENDKNTPKEAKQFLNSLGDKVHGKFGEGRILSTRLVNALITDDGKVYVGAVTKDQLVKTADAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTY5</accession>
    <name>A0A0F4JTY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_06230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000116">
        <property type="protein sequence ID" value="KJY37218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946359.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000116.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene80"/>
    <dbReference type="EnsemblBacteria" id="KJY37218">
        <property type="protein sequence ID" value="KJY37218"/>
        <property type="gene ID" value="VR44_06230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3000"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="24226" checksum="A9C8C3C22BF57ED9" modified="2015-06-24" version="1">MPLTSPRRSALVDQVIAQLRNQITSGEWPVGSRIPTEPELVELLGVARNTVREAVRALAHNGLLDIRQGSGTYVLATSELAGVMHRRFAGADPRHIAELRSTLESSAARLAAERRTERDLVQLDALLARREEAWASGDAELFVSTDVALHMAVVTASHNEVLTGLYADLGDLVAEWLRADVGTVLDPAAHLDHARLIEAIRRGDGDAAASEAAGYPFVCLGKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU51</accession>
    <name>A0A0F4JU51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosysynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000158">
        <property type="protein sequence ID" value="KJY36486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946677.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000158.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36486">
        <property type="protein sequence ID" value="KJY36486"/>
        <property type="gene ID" value="VR44_07930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4407"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19545" checksum="917E0EC0FA54BF41" modified="2015-06-24" version="1">MNGTTTAQVAAVSSNGEYSFTKPNRESITLLTGLGVEGDVHAGVTVKHRSRVAQDPTQPNLRQVHLIHRELFDEVARAGFSVAPGQLGENVTTEGIDLLALPTGTLLGIGEQAVVEVTGLRNPCPQINAFQDGLLKQVVGRDEEGRVVRKAGIMGVVHRGGTVRPGDTITVTLPPLPHIPLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUF5</accession>
    <name>A0A0F4JUF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_04900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000090">
        <property type="protein sequence ID" value="KJY37815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946112.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000090.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37815">
        <property type="protein sequence ID" value="KJY37815"/>
        <property type="gene ID" value="VR44_04900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1065"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21389" checksum="F928E36819C1599C" modified="2015-06-24" version="1">MVRAGLNAARLTEAAAEMADETGIEQLSLSALARRFGVKDASLYSHVRNLRDLRVRVALLAGEEMTERIAVAVAGRSGKDALVAFADAYREYALERPGRYAASQMRFDPEEVAGSAGLLRSVELTYGMLRGYGLEEPDLTDAARLLRATFHGYVHLELSGAFSHSREVRTSWARGLDALHAALENWPPKNKGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUS8</accession>
    <name>A0A0F4JUS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000142">
        <property type="protein sequence ID" value="KJY36741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36741">
        <property type="protein sequence ID" value="KJY36741"/>
        <property type="gene ID" value="VR44_07305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3932"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="27304" checksum="2DB2A8FFC6069312" modified="2015-06-24" version="1" fragment="single">MTDGSAGALTVTLCRDSRQFAALEESWNRLVRECPTATPFQSHAWLHSWWLSYGKDGRLRILLVRRGEELVGAAALMLVHRPLPRLVPLGGPITDYFDVLVSREHAGQVVPALAQGLHRAARSAVVDLREVRPGAAAEALFEAWPGVSSRLTDSTCMELPALPFDQLVKRMPASGAQRVRAKLRKTDAAGIEEHEVTEREVPQAVRTLLRLHEKQWRGRGVTPEHLRPRFAEHLTRATRRMVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUU7</accession>
    <name>A0A0F4JUU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000140">
        <property type="protein sequence ID" value="KJY36761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36761">
        <property type="protein sequence ID" value="KJY36761"/>
        <property type="gene ID" value="VR44_07280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3797"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24511" checksum="3EF03B0F94F76CE0" modified="2015-06-24" version="1" fragment="single">TWSRPGPAAGWLTGEALAEVSIRLRAAAGRPPLSLRPGEARARALLARHAADHRVFEQAVEVRSQRLHAPFLDNQVVRAARALPESLRVQPGARAEILRSVLASAGVRELPPGWGVTAPGPNETAGRLGLRAALARLLALFDAPLLADAGLVEARVVRQALTDAADGRPVPLDGLAELVSMELWLRRLMSRRGTCWTGTSTPRRRAVPPLPAPLPRLPGAPLPLGRPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUY9</accession>
    <name>A0A0F4JUY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000135">
        <property type="protein sequence ID" value="KJY36801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946529.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000135.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36801">
        <property type="protein sequence ID" value="KJY36801"/>
        <property type="gene ID" value="VR44_07145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3773"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="86" mass="9380" checksum="FE247A5DE54726F3" modified="2015-06-24" version="1">MGRGRAKAKQTKVARQLKYNSGGTDLTRLANELGASPTEPLPISAPVEVDDDLDDDDPYAKYADLYNDDDEDEDEESGPTAHRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXJ3</accession>
    <name>A0A0F4JXJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_03675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945897.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5773"/>
    <dbReference type="EnsemblBacteria" id="KJY38448">
        <property type="protein sequence ID" value="KJY38448"/>
        <property type="gene ID" value="VR44_03675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8273"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="29703" checksum="C16B453708DD5299" modified="2015-06-24" version="1">MRPATVAKNLGALLLALVFVFPVYWMFSSALKPNSEILTKDPVFVFTPTLDNFTKATGVENFWTYVTNSLVVTVGAVLLALLVALAASFAIARMKFKGRKGLVLGVMMAQMAPWEVMVIAMYMIMRDAEMLNSLGVLTAIYFVMVLPFTIWTLRGFIAAVPVTLEEAAQIDGCTRGQAFRKVIFPLLAPGLMSTSLFGFITAWNEFAMVLILNKDKTAQTLPLWLTQFKTAFGNDWGATMAASSIFAIPVLVIFIFLQRKAVGGMTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYW1</accession>
    <name>A0A0F4JYW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000016">
        <property type="protein sequence ID" value="KJY39562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39562">
        <property type="protein sequence ID" value="KJY39562"/>
        <property type="gene ID" value="VR44_01270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2971"/>
    <dbReference type="eggNOG" id="ENOG50342FG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="15036" checksum="8B666BD8F5A4C1B3" modified="2015-06-24" version="1">MLSSLGLSRSSRTPAGARPDTGPARPGPPEQPRTDSRCGPELSAPQGLEAQTCVLVSEGRTWGRSYYRNTSGRALDAVLTVMGPAGRTVQIRCAVAAGDEPGLCETPRGESAGAPDAYSAVAEFAVPDDEGRLLLRSGSNSPAPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZH1</accession>
    <name>A0A0F4JZH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39505">
        <property type="protein sequence ID" value="KJY39505"/>
        <property type="gene ID" value="VR44_01515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4736"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="104" mass="10813" checksum="5E95566643991C79" modified="2015-06-24" version="1">MMRSPRELVGGSPAATYPIAFDGRELPAQEGQTIAAVLWAAGILSWRTTRDGGAPRGAFCGIGACYDCLVTVNGRPNQRACLVPARPGDTVTTQEGTGHADLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1E5</accession>
    <name>A0A0F4K1E5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ORF">VR44_00290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945287.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1026"/>
    <dbReference type="EnsemblBacteria" id="KJY39934">
        <property type="protein sequence ID" value="KJY39934"/>
        <property type="gene ID" value="VR44_00290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.56"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="30499" checksum="7AA4030646434F9A" modified="2015-06-24" version="1">MGIRKYKPTTPGRRGSSVADFVEITRSTPEKSLVRPLHSKGGRNNTGRVTVRHQGGGHKRAYRVIDFRRHDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIIAPRGLQQGDRIENGPTADIKPGNNLALRNIPVGTTIHAIELRPGGGAKFARSAGASVQLLAKEGVMAHLRMPSGEIRLVDARCRATVGEVGNAEQSNINWGKAGRMRWKGVRPTVRGVAMNPVDHPHGGGEGKTSGGRHPVSPWGQKEGRTRSPKKASNKYIVRRRKTNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2K1</accession>
    <name>A0A0F4K2K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000021">
        <property type="protein sequence ID" value="KJY39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39411">
        <property type="protein sequence ID" value="KJY39411"/>
        <property type="gene ID" value="VR44_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8511" checksum="7DE35D6CA636C7B1" modified="2015-06-24" version="1">MGGRRGVFLRLLVLLRLLLLVRFLLLRFVLRWRRVRGQLTLERGGASRVDRTPGGDNFLRASSCSGAYEGMGTACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICM2</accession>
    <name>A0A0F4ICM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001560">
        <property type="protein sequence ID" value="KJY19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19218">
        <property type="protein sequence ID" value="KJY19218"/>
        <property type="gene ID" value="VR44_39180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14114" checksum="D6E112F1B88440AD" modified="2015-06-24" version="1" fragment="single">MRNRLASATGVSLPAGLVFDHPTPDALARHLLRRLTDAPRPGPATRTATPSGTATDEPVAIVAMGCRYPGGVRSPEDLWRLLTTGTDAIGGFPEDRGWNLDLLSASGGTAGSSSTLQGGFLYDAAEFDAAFFGISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ICS0</accession>
    <name>A0A0F4ICS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001559">
        <property type="protein sequence ID" value="KJY19273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19273">
        <property type="protein sequence ID" value="KJY19273"/>
        <property type="gene ID" value="VR44_39175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="662"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY19273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="703" mass="72288" checksum="8C528E7F4437FD5C" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IE77</accession>
    <name>A0A0F4IE77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_38725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001510">
        <property type="protein sequence ID" value="KJY20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952376.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001510.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20302">
        <property type="protein sequence ID" value="KJY20302"/>
        <property type="gene ID" value="VR44_38725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5429"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="210" mass="23574" checksum="3D681CE18B0EAB9E" modified="2015-06-24" version="1">MRYHPSLWQVDPVARRRAVAQAVLSVAARQGLEHASLRNVAEEAGLAVGSVRHYFAAHDELMTFAMRELSRYIGDRIRSHTERLLTPSSGTDRRAATEELLAEFLPMDEDRRQESALWLAFITATLTRPELRPCAMGMRANLHNLISRVLHEARCAGGLPGGLDIELESTRLAALLDGLTLQATLLPNRYPPKRLRQVLRRHLDALRADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IIR9</accession>
    <name>A0A0F4IIR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001458">
        <property type="protein sequence ID" value="KJY21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21378">
        <property type="protein sequence ID" value="KJY21378"/>
        <property type="gene ID" value="VR44_38295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5268"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="105" mass="11123" checksum="5FCEF23744C34159" modified="2015-06-24" version="1" fragment="single">VLRGTVKTNEWINANPDKAKASANAKLKADSGKELDAKVLDPAWQSILVTDDPLATTLKTEADWAVKAKLLDKPDLTGIYDLTLLNKVLKAAGKPEVGDGGLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILM5</accession>
    <name>A0A0F4ILM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001453">
        <property type="protein sequence ID" value="KJY21516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21516">
        <property type="protein sequence ID" value="KJY21516"/>
        <property type="gene ID" value="VR44_38255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8615" checksum="B3F6E2FC22E76B71" modified="2015-06-24" version="1" fragment="single">LPRLDGWSSTAEDFWRLPVDTGRLRADRLGATEQDIASYITGPVSTELPAQTGREMLRTNSRLPELFAQARARSQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IMH6</accession>
    <name>A0A0F4IMH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_37745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001406">
        <property type="protein sequence ID" value="KJY22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952191.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22874">
        <property type="protein sequence ID" value="KJY22874"/>
        <property type="gene ID" value="VR44_37745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5055"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="111"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="44535" checksum="E13C42FC608A815E" modified="2015-06-24" version="1">MRDGAGIPDDAGTAAGAGTPRRGRRRRLLLRWIGLGAVLLVLAGAAAGWWLYAKLDGNITEDTSAASELRRYERERPEHFASGAQNILLIGSDSRAGPENAGYGQDGGTQRSDTTILLHLAADRRSATAVSIPRDLMTDVPECLGADGSRTGDRFAQFNWAFQWGGAACTIRTVEKMTGIRVDHHMVVDFGGFKKMVDAVGGVEVCLRRPVDDAEAHLRLPAGRQVLGGEQALGFVRARYSLGNGSDTERMERQQQFLGSLWEKVSSNGVLLNPAKLYPVLDAATSSVTTDPGLASLRGLYELARGVRDIPADQVKFLTVPRRPYAADPNRDELVQPDAARLFERLRADRPVVVTVPEVSPSPDPEPARPSPGVSAEDSEEPSDDGSGGPSPTGSGTPQTATPAPAFTGTTAATADCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPL4</accession>
    <name>A0A0F4IPL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001321">
        <property type="protein sequence ID" value="KJY23965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952003.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001321.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23965">
        <property type="protein sequence ID" value="KJY23965"/>
        <property type="gene ID" value="VR44_36720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470293" evidence="1">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23228" checksum="5EB8911BD39895C3" modified="2015-06-24" version="1">MFRTVFTAGAAAALAAAALTPSAGAATGGGASFAPPEQITIDVVQVNGSGCRPGSATVAVAPDNTAFTVTYSEYLAQVGPDAKATDFRKNCQLGLSLNVPQGYTFAIAQADYRGFASLQQGATATQKASYYFQGMSQTASRSHTLRGPLQDGWQVSDTVPVEALVFHPCGAKRNLNINTELLTQAGTSDPARTTSFLTMDSTDGSINTKYHFAWKTCPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPQ2</accession>
    <name>A0A0F4IPQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001317">
        <property type="protein sequence ID" value="KJY23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23982">
        <property type="protein sequence ID" value="KJY23982"/>
        <property type="gene ID" value="VR44_36685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4646"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="184" mass="19982" checksum="A3130153B155618C" modified="2015-06-24" version="1" fragment="single">LMRSLRPVGRRSIGGPGEELDEQLTVERSIEAMVPTPVLRPAESRWLDLALVVDAHHSMLLWADLVAELSGVLTRSGVFRDVRTWQLTGTGPGGTPQLARGPGEPPRNPLELADPAGRRLILVLSDTVAGGWQEGPLRAVLRHWSGHNAVAVLNVLPERLWTRGAVRPVPFAVRSDRPAAATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRB1</accession>
    <name>A0A0F4IRB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001212">
        <property type="protein sequence ID" value="KJY24527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951698.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001212.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24527">
        <property type="protein sequence ID" value="KJY24527"/>
        <property type="gene ID" value="VR44_35105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4098"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="398" mass="44132" checksum="D98FAB412815BF9F" modified="2015-06-24" version="1">MSQGLPVTFSTVREGYFNPPPATRSLRRTEPLTRMEFADGHLGWLVTGYSAARAVLADARFSARGELKHPPVPRAATLDEAPAAPPGMFIQHDDPEHQRYRKLLVGQFTVRRMRLLTEWIEKITAERLDEMERLGSPADLFEHFALPIPSLVICELLGVPYADRATFQHHTHVWSSFGESTEDVTAAFLELGAYLGGLVRLKRTEPADDIISGLITADPDLTDEELTSIAFLLLVAGHETTANQLALGTFALLEHPEQLAALRADPSLIEGAVEESLRFLSIVHHGPTRAALEDVEVEGTLIREGEVVMVSLAAANRDPERFPDPESFDVTRRAAGHLGFGHGIHQCLGQQLARIELRVGFTALLERFPQLRLACPPEEIRLRHDMQVYGVYALPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT23</accession>
    <name>A0A0F4IT23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001114">
        <property type="protein sequence ID" value="KJY25155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951360.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001114.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25155">
        <property type="protein sequence ID" value="KJY25155"/>
        <property type="gene ID" value="VR44_33265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3529"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="25347" checksum="6B6D837389E0AA9F" modified="2015-06-24" version="1">MAVIVALGAFLMTLAGGWTAQRVTDRRHLVLGLAGGLMLGVVGLDLLPEALHAAGEEVFGVPLALLLFVAGFLVAHLVERLLAVRQAPHGGSDGAGHGHDHGGRVPQVGLVAAAAMVGHSLADGVALGVAFQVGGGMGVAVALAVLTHDFADGFNTYTLTRLYGNDRRKALMMLFADAAAPVVGAASTLLFTLPEEPLGAYLGFFGGALLYLAAAEILPEAHHEHPALSTLMCTVGGVAGIWLVVGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT42</accession>
    <name>A0A0F4IT42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001191">
        <property type="protein sequence ID" value="KJY24633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951632.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24633">
        <property type="protein sequence ID" value="KJY24633"/>
        <property type="gene ID" value="VR44_34770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4023"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="16668" checksum="562E427CAB983FD5" modified="2015-06-24" version="1">MAEPRVLRSDKGTVAVLREVRYEVRIKKLGATGERALRDPGTLTQRVPAEHLVPVGTDRPGLSRVLAPATAYVSVADSLAPLAVAERGATHQGGGGLFDAVASVLHPDVTAPGAPGRGGVPRDAGMVHLTPPALVPGAVPCCGESLHGRHHQRRAHEWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT45</accession>
    <name>A0A0F4IT45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tellurium resistance protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_33235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001113">
        <property type="protein sequence ID" value="KJY25167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951356.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001113.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25167">
        <property type="protein sequence ID" value="KJY25167"/>
        <property type="gene ID" value="VR44_33235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3522"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="328" mass="35793" checksum="5455292406204449" modified="2015-06-24" version="1">MDVSLTLWVLTIIGLGILIGADFLIGRKPHDVSIKEAGTWTVVWIVLAVLFGLGLLFTGNGQASQEFFAGFITEKSLSVDNLFVFVLIMAKFSVPSHLQQRVLLIGVLIALVLRAVFIAAGAAIITTFSWVFYIFGAFLIYTAWKLIQEARKDEDEEEFEENRLLKSIEKKFGVADRYHGTKLFIRNNGKRVLTPLMVVMLAIGTTDVLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLKKLVHLSYGLSVILGFIGVKLVLHALHESGVHVPQISIPVSLGVICGVLVVTTITSLIASKKQAAAEAAAEETEIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT54</accession>
    <name>A0A0F4IT54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001112">
        <property type="protein sequence ID" value="KJY25177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951350.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001112.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25177">
        <property type="protein sequence ID" value="KJY25177"/>
        <property type="gene ID" value="VR44_33205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3516"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="17946" checksum="B219AE7A37259C05" modified="2015-06-24" version="1" fragment="single">LQVAVVADLTDESALLPVLAGRDAVVSALGAANNKQARLAPVTGPALRAVVAAMRRTGVERLMAVSAAPLAPDSKGDGLLVRKVGYPLLRRALRDLYADLAVMESVIAAASGLRWTVVRPPRLLNRLGTGYYRRALDANVPGGRVIPRADVATALLDLLSDPSTAGHAVGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU36</accession>
    <name>A0A0F4IU36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_32280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001062">
        <property type="protein sequence ID" value="KJY25517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25517">
        <property type="protein sequence ID" value="KJY25517"/>
        <property type="gene ID" value="VR44_32280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3178"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY25517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22911" checksum="27C35A5E6995A0C1" modified="2015-06-24" version="1">MIAEDSVLLRIGLVKVLEMAGFEVAAETGDAEALLAAVEEHRPDLALVDVRMPPGFTDEGVRAALMIRSQSPETAVLLLSQFVEERYAADLLSSQSGAGIGYLLKQRVADVEEFIDALRRVAAGGTALDPQVVAQLLLRRGGPDPLERLTPREREVLALMAEGRSNAGIAEGLVVSESAVAKHINNIFTKLDLPPAAEAHRRVLAVLRFLDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUP3</accession>
    <name>A0A0F4IUP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951088.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25727">
        <property type="protein sequence ID" value="KJY25727"/>
        <property type="gene ID" value="VR44_31785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3068"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="178" mass="19058" checksum="92ABF6DC0C84D265" modified="2015-06-24" version="1">MAEQKRAPLPHDFHPEVASFTVTSEDVSPGADLHAAQVLTGKNLSPQLSWEGFPEGTKSFAVTCFDPDAPTGSGFWHWVLFDIPASVTSLPAGAGSGDFVGLPEGAVHVRNDYGTRDFGGAAPPRGERHRYVFTVYAVDREQLGPDADSSPAVVGFHLRFHALGRAQLIGEYESPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVJ5</accession>
    <name>A0A0F4IVJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001038">
        <property type="protein sequence ID" value="KJY25664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951108.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25664">
        <property type="protein sequence ID" value="KJY25664"/>
        <property type="gene ID" value="VR44_31885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3091"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="18707" checksum="AEC4B8E749228BAF" modified="2015-06-24" version="1">MPTSPALPVILLLSGSLRAGSVNEAVLRTAESVAAAGAVPVAAVRYEGLADLPHFNPDQDTDPLPAPVAALRGAIAGAAALLVCAPEYAGTLPGSFKNLLDWTVGGTEISDKPVAWVNAAAPGRGGGAEATLRTVLGYTGAAVVDAACVRIPVDRATVGADGAVSDPAVRARLAEVLALLADAAREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW82</accession>
    <name>A0A0F4IW82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001013">
        <property type="protein sequence ID" value="KJY25899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950996.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25899">
        <property type="protein sequence ID" value="KJY25899"/>
        <property type="gene ID" value="VR44_31305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2749"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="356" mass="37945" checksum="C3165CAA7A0CEA9A" modified="2015-06-24" version="1">MELTSTSFLVTLIAVTALAMLLALLLWNRVPGPAVLRWVARVLMIGVCQLTAIGVVAAWINDGYGLYASWDDLLGTGADASASAMTGPPLGRARFTPGENGTRSTYFRGSHSKLAGQVIVWTPPEYDAPGAEKTRFPVLTLLHGYPGTPRSWIDLGSMPDALEQLVRLGASQPFILVIPELYPGGVNTDCSDTPQRKVATWLARDVPDLVQKNFRTLPQPKGWGLMGVSTGAFCAAKLPLQYPKVFRAGAALDPDPLTGDPQVLPDAALRERNSPMWLVGQAKGEDVALFLATSAQDRDSPPKQLAAFSGAAQGSGIRVKTLVRPAGGHNFQTWTGMYPDALGWLSTELSAPAGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWZ9</accession>
    <name>A0A0F4IWZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000928">
        <property type="protein sequence ID" value="KJY26537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26537">
        <property type="protein sequence ID" value="KJY26537"/>
        <property type="gene ID" value="VR44_29820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2344"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470344" evidence="2">
        <location>
            <begin position="29"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="341" mass="35905" checksum="A4E75F6F99D6F375" modified="2015-06-24" version="1">MRLRTTVLRTLLLGLCGLLLLPAGRAAAADNGTWGVFPTPPAGAAMTDRAYFFHQGAAGAAISDSVTILNSSDRELTFRVFATDAMNTPSGGAFALLPAETRPRDVGTWIALPPEAAGTVTVPPKGRKDIPFTVKVPQDAAPGDHVGGIVALNTAVEGITKEGKVQVGVRRQVGARLYLRVPGPLTPALSVEDVRVSRGAPLLPWTKDARATITYTLVNRGNVVVEPKVSVAARGLFGRRLLDRPARAPQPALLPGQRIVLTEPWPDSPQLDRVEVKVTARAAAYPDVDSEAGTAFLAVPWPAAGALLLAAGTALALLVRRRRRRAAPDVPRPAPDLAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXB0</accession>
    <name>A0A0F4IXB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000914">
        <property type="protein sequence ID" value="KJY26647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950682.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000914.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26647">
        <property type="protein sequence ID" value="KJY26647"/>
        <property type="gene ID" value="VR44_29565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2290"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18752" checksum="093FED46349D890B" modified="2015-06-24" version="1">MTADQQEQDVVEVILEDHRTMEELFRQMRSVEADRAGALKKFSALLIAHGEAEESEVYGALKRFRKVDDEEVEHGVEEHEEGNKALLALLEVAGVGSEDWDAKLEDLVEAVTHHLDEEERTILNGARENVPDERRAELGAAFLKERERQLESDCGSIENVRTVVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXF0</accession>
    <name>A0A0F4IXF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation factor Sua5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950652.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000909.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26715">
        <property type="protein sequence ID" value="KJY26715"/>
        <property type="gene ID" value="VR44_29405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22707" checksum="970F32BA353415FA" modified="2015-06-24" version="1">MAKYFDVHPENPQRRTISGVADSIRSGALIAYPTDSCFALGCQLGNREGLARIRQIRELGDKHHFTLVCQNFAQLGQFVHVDNDVFRAIKASTPGAYTFILKATSEVPRQLLHPKKKTVGVRIPDHLVTQALLEELGEPLLSSTLLLPGEDEPMTQGWEIKERLDHVVDAVVDSGDCGTRPTTVIDFSTGEAEIVRRGAGDTARFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYS2</accession>
    <name>A0A0F4IYS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001021">
        <property type="protein sequence ID" value="KJY25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951040.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25821">
        <property type="protein sequence ID" value="KJY25821"/>
        <property type="gene ID" value="VR44_31540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2804"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16175" checksum="30369FC0C6B3D3E5" modified="2015-06-24" version="1">MKGRPVFDQAELRSTAPAMTYEQMLEAVRYEGAYPDTTRAAEAVHHVLAGLGRRLTGEERVDLAARLPTEAALVLTAQVPAFDELTGWGFVKDLASRAGTTQAVARWETGAVLSVVARLAGPELLARILRSLPGGYALLFGQAELTTAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYW3</accession>
    <name>A0A0F4IYW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <shortName evidence="6">HMG aldolase</shortName>
            <ecNumber evidence="6">4.1.1.112</ecNumber>
            <ecNumber evidence="6">4.1.3.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22748"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:58276"/>
            <dbReference type="EC" id="4.1.3.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="6"/>
    <dbReference type="EC" id="4.1.3.17" evidence="6"/>
    <dbReference type="EMBL" id="JZWV01000860">
        <property type="protein sequence ID" value="KJY27192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950434.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000860.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27192">
        <property type="protein sequence ID" value="KJY27192"/>
        <property type="gene ID" value="VR44_28220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1886"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010203">
        <property type="entry name" value="RraA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01935">
        <property type="entry name" value="NOT-MenG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="160" mass="16184" checksum="F423868779073D04" modified="2015-06-24" version="1">MSVTPVPTADLYDEHGESLGICTTAFRTVGGRRLFAGPVRTVRCHEDNALLRELLHTPGEGAVLVIDGGGSLRTALVGDLIAGAAERSGWAGLIVNGAVRDSVALGGLDLGVHALGTCPRKSGKTGAGAVDEPVTIGGVTFRPGDTVYADDDGVVVLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZ39</accession>
    <name>A0A0F4IZ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001010">
        <property type="protein sequence ID" value="KJY25921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950980.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25921">
        <property type="protein sequence ID" value="KJY25921"/>
        <property type="gene ID" value="VR44_31220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2731"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="28590" checksum="7CEB235F0080FF2E" modified="2015-06-24" version="1">MGVWFVTGASRGLGAEITREALDRGHSVIATARDVSAVLDAYPEKPDGLLAVNADVTRPEQLALAVEAGLAAFGRIDVVVNNAGYGLVGAIEEISDGAARELFDVNVFGVLNTLRATLPTLRSQRSGHVLNIGSVGGFATAPAVGLYGASKFALEGISEALHGELAPLGIRVTIIEPGGFRTDFLNSSSIRVEPAAIADYVAGAGPVREALAANDGLQPGDPAKAAKAVVDVTETDEPPLRLQLGADAVERVEAKLALVRRELDQWRHTALSTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZA8</accession>
    <name>A0A0F4IZA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADH_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000999">
        <property type="protein sequence ID" value="KJY25996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25996">
        <property type="protein sequence ID" value="KJY25996"/>
        <property type="gene ID" value="VR44_31075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15132" checksum="715E872EA059F42D" modified="2015-06-24" version="1" fragment="single">SVLACGTCDTCLRGRRNQCERAVLTGLTAPGALADYIVVPQTACHRLSLLREGGWSRQDTLLAGALLEPLGCVYNAVFVEGGGIRPGERVTVHGLGPLGLFAGVLCHIGGASRVVGVDPVPGRRDLAQRLGFSACLSPGSAQTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZC1</accession>
    <name>A0A0F4IZC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">VR44_28660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="JZWV01000880">
        <property type="protein sequence ID" value="KJY26984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950517.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000880.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5484"/>
    <dbReference type="EnsemblBacteria" id="KJY26984">
        <property type="protein sequence ID" value="KJY26984"/>
        <property type="gene ID" value="VR44_28660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2063"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046936">
        <property type="term" value="F:2'-deoxyadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="42257" checksum="887BA8CA4BB59065" modified="2015-06-24" version="1">MTSETPNTPSPDQIRRSPKVLLHDHLDGGLRPGTIIELAAQVGYDKLPESDADKLGVWFRDAADSGSLPRYLETFAHTCAVMQTKEALFRVAAECAEDLAEDGVVYAEIRYAPEQHLEAGLTLEEVVEAVNDGFREGERRAKANGHRIRIGALLTAMRHAARALEIAELANRYRDNGVVGFDIAGAEAGFPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVKIIDDIEVAADGSVKLGRLASYVRDKRIPLEMCPTSNLQTAAAASYAEHPIGLLRKLHFRLTVNTDNRLMSGTSMSREFEHLVEAFGYSLDDMQWFTVNAMKSAFIPFDERLAMINDVIKPGYAELKSEWLFRQTASTSGSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Z7</accession>
    <name>A0A0F4J0Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000781">
        <property type="protein sequence ID" value="KJY27945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1194"/>
    <dbReference type="EnsemblBacteria" id="KJY27945">
        <property type="protein sequence ID" value="KJY27945"/>
        <property type="gene ID" value="VR44_26395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1463"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="380" mass="41111" checksum="3BDC59D9F6AC24AC" modified="2015-06-24" version="1" fragment="single">MHSDEPKWTPSNESLDPSRPAPADRPRELRRILGLFRPYRGRLAVVGALVGASSLVGVASPFLLKEILDVAIPQGRTGLLSLLALGMILTAVVTSVFGVLQTLISTTVGQRVMHDLRTAVYAQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTAVVASVVAMLALDWRLTLVSLLLLPVFVWISRRVGRERKKITTKRQKQMAAMAATVTESLSVSGILLGRTMGRSESLTAAFAEESEKLVGLEVRSSMAGRWRMSTIGIVMAAMPALIYWAAGIALQTGAPSLSVGTLVAFVTLQQGLFRPAVSLLSTGVQIQTSLALFARIFEYLDLPVDITERQDPVRLGRAKGEIRLEDVHFAYEAKNGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1G8</accession>
    <name>A0A0F4J1G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000905">
        <property type="protein sequence ID" value="KJY26766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950626.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000905.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26766">
        <property type="protein sequence ID" value="KJY26766"/>
        <property type="gene ID" value="VR44_29255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2198"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="109" mass="11796" checksum="DA128F753DA835BD" modified="2015-06-24" version="1">MYTDPDDLKRARSVGANAPAEFAAWRAFQEAVDREDGAVPRRYRELISVAVALVTQCAYCLDVHTAAARRHGVTAEELAETAFVTAAVRAGGTLAHALMADRLYEGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J289</accession>
    <name>A0A0F4J289_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000790">
        <property type="protein sequence ID" value="KJY27868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950132.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000790.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27868">
        <property type="protein sequence ID" value="KJY27868"/>
        <property type="gene ID" value="VR44_26560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="11"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="252" mass="27010" checksum="91F3D4A6B405570B" modified="2015-06-24" version="1" fragment="single">MSAAPAAFAALFQPYTLRSVTIPNRIWMAPMCQYSAEAFGPNAGVAGEWHFAHYAARATGGTGLVIQEATAVSPEGRISPYDLGIWNDTQVEALRRITAFVKSQGAVPGIQIGHAGRKASTDQPWNGGAPVGPEAHGWQPSAPSAVAFDEGHPVPHELTVEEIHEITGKFAAAAGRALAAGYEVLEIHGAHGYLIGEFLSPHSNRRTDAYGGSFENRTRLALEVVDAVRAVWPEELPLFFRISATDWLEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2K5</accession>
    <name>A0A0F4J2K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000778">
        <property type="protein sequence ID" value="KJY27963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950087.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000778.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27963">
        <property type="protein sequence ID" value="KJY27963"/>
        <property type="gene ID" value="VR44_26320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1419"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="126" mass="13262" checksum="EDA35E26A7A0D169" modified="2015-06-24" version="1">MDGRWYDADAGPLVRPYAMTGGRTKPGPHGVRFDLIALVAVDPGGGAVGDEGLLGPEHRALLGLCRSETQSVAELAAEADLPVGVVRVLLGDLLEAGQVKVSRPVPPARLPELRILREVIEGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2R2</accession>
    <name>A0A0F4J2R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_28060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000855">
        <property type="protein sequence ID" value="KJY27251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950408.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000855.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27251">
        <property type="protein sequence ID" value="KJY27251"/>
        <property type="gene ID" value="VR44_28060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1825"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="27809" checksum="D5E31E6C12EBBC99" modified="2015-06-24" version="1">MRHTLDIDGRTLSYLDSGGTGRPLLALHGGMSEARAFTGLATALGEEWRVIAPDQRGHGDSDRAPDYRREGYVADAVALLDHLGLTEPVALLGYSLGGLNAYHLAAAHPDRIGVLIGVDANIDIHIPAGPHWFDFLGALPYTAPTREELLAAVDPAALPFVADGVRPLPGGEGWRLAFHGQDMLDSIRACAGDHWDTWLASTCPALLIHATGSQALPQATATAMVTRRPNTAYTPLDGDHFVPFTDPEGFHAAVAEYLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3V7</accession>
    <name>A0A0F4J3V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000683">
        <property type="protein sequence ID" value="KJY29022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29022">
        <property type="protein sequence ID" value="KJY29022"/>
        <property type="gene ID" value="VR44_23935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.762"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009334">
        <property type="entry name" value="DUF993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06187">
        <property type="entry name" value="DUF993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="15048" checksum="A6F3B125E1E69FEA" modified="2015-06-24" version="1" fragment="single">MLLPSADGGLRLYRPSAAPLGPFGGGPARSRIFHAAAHVAAAPATPSERGGPVVDWEATLGFRHRLWALGLGVAEAMDTAQRGMGLGWPEAAELIHRSAGEARAVGGRIVCGAGTDQLRPGRVHSLAAITAAYGEQLAHIEGCGAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Z4</accession>
    <name>A0A0F4J3Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000809">
        <property type="protein sequence ID" value="KJY27661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27661">
        <property type="protein sequence ID" value="KJY27661"/>
        <property type="gene ID" value="VR44_27105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1606"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="52" mass="5207" checksum="D6F5DBDEB3E70C00" modified="2015-06-24" version="1">MTGSVKAMAVTTFAALVAVSTYSVALGSNGWLWFGWVVLGLLTLGMAAAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4G6</accession>
    <name>A0A0F4J4G6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsQ</name>
        <name evidence="10" type="ORF">VR44_23415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949548.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29247">
        <property type="protein sequence ID" value="KJY29247"/>
        <property type="gene ID" value="VR44_23415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.625"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="279" mass="28827" checksum="73931CF42743A5AF" modified="2015-06-24" version="1">MAGATTARRGASGRPDGGGKGAGVPKPPRPPKSPKGTGPRGSGGGRPRRVRLLVTLAAAALLAGGGTWALYGSSWLRVEKVTASGTEVLTPEQVLNAAAVPVGAPLVSVDTDEIASRLRGRLPRIDSVDVVRAWPHGIGLKVTERKPVLLIKNGADFIEVDGKGVRFDTVAKAPVGVPLLEMTADRSPSARRFDEERLLREAVGIAGGLPDAVAKETLQVKVRSFDSVVLELTKGRSVVWGSGELGEAKGRALTALLKAAPKADHFDVSVPTAPAVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5D8</accession>
    <name>A0A0F4J5D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_22595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949399.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000042_gene5999"/>
    <dbReference type="EnsemblBacteria" id="KJY29567">
        <property type="protein sequence ID" value="KJY29567"/>
        <property type="gene ID" value="VR44_22595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.411"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="46019" checksum="C8DD3E9137499CBA" modified="2015-06-24" version="1">MSASPQAQAPAKASFKFPFWAQIVAGLALGVLFGWIARSQDVSWLKTTLEQVGDIFIQLLKLAVAPLVFFAILVSITNLRKVNNAARLASRTLLWFMITSLIAVGIGLAIGLLTDPGAGTGLTPADGKEPKRHGSWIDFLTGIVPKDIVTPFTELNVLQIVFLAAVAGIAALQLGAKAQPVLNLAESVLELLQKALWWVIRLAPVGTVGLIGTAIASYGWDLIGKYATFTADIYIGCALVMFGVYPLLLATVAKVNPVQFFKGAWPAIQLAFVSRSSVGTMPVTQKVTERLGVPKEYASFSVPFGATTKMDGCAAIYPALAAIFIANIFDVQLGIKEYLLIAFVSVVGSAATAGLTGATVMLTLTLSTLGLPLAGVGLLMAIDPILDMMRTATNVAGQAVVPVLVSAREGILDKEAYAAASSSPLDEPAAAQPAPVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5U6</accession>
    <name>A0A0F4J5U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000670">
        <property type="protein sequence ID" value="KJY29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29138">
        <property type="protein sequence ID" value="KJY29138"/>
        <property type="gene ID" value="VR44_23650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.674"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="396"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="49307" checksum="CADDB700181EBFB0" modified="2015-06-24" version="1" fragment="single">AHASRLRAKASAMTEPGLGAVQPLLDAADRLMHLDRAAARETCLAAFGAAIWAGRYDGSGLRRAAAAARELPPGDETAGVFLRALVTWTEDGPTAAFPLLARALRSLTRDEDLAVLWPAANAAVELGDLRAWLDITGRAVRFARTTGALSVLSTALPYRAASLCYAGRFEEARDLLAEAPAAGDAAGVATNMVSTALLSAYQGRERPALELIGAMEREGERRGLGRLTGMAACARSVLHNGLGNYALAVEAALRGGEYQDLVVHHWTDCELVEAATRAGRPDVAARARERLADWGRAGTPWALGAQAVADALTGAPERAEDRYREAVDHFARGGLGVFEARTRLLLGEWLRRRNRRSDARDELREAHSAASAMGMEAYAERARRELLATGETVRARTPGPPVLTAQEARIARLAATGHPNAEIGAQLFLSPRTVEWHLRKVFAKLGVSSRREIDGALADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J674</accession>
    <name>A0A0F4J674_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VR44_23165</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000652">
        <property type="protein sequence ID" value="KJY29339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949502.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000652.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29339">
        <property type="protein sequence ID" value="KJY29339"/>
        <property type="gene ID" value="VR44_23165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.572"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJY29339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28746" checksum="ADE910F7A4427FF1" modified="2015-06-24" version="1">MPEGDSVHRVAARLHAALAGKPLTHADLRVPRFATADLAGRTTLDVTPRGKHLLARLEGGLTLHSHLGMDGAWYVFGPAEKWRGGPSYEIRAVLAAADATAVGYRLPVLELLRTAEEDRAVGHLGPDLLGPDWDAGRAAGNLLATPGRPLGEALLDQRNLAGIGNIYKSELCFLAAVTPWTPVGALPDPEVTAVRIAAAAQRLLAANTGHGGPRNTTGSHRPGRELFVYGRAHRPCLRCGTAVREAPQDDRPTYWCPRCQSGPTPDTPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6A0</accession>
    <name>A0A0F4J6A0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_21730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949239.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29892">
        <property type="protein sequence ID" value="KJY29892"/>
        <property type="gene ID" value="VR44_21730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.226"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="13">
        <location>
            <begin position="33"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="14">
        <location>
            <begin position="453"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY29892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="587" mass="60928" checksum="130D733CEC568B47" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6U1</accession>
    <name>A0A0F4J6U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavoprotein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949142.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5504"/>
    <dbReference type="EnsemblBacteria" id="KJY30082">
        <property type="protein sequence ID" value="KJY30082"/>
        <property type="gene ID" value="VR44_21240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8972"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="359"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="479" mass="50132" checksum="582494188D34E904" modified="2015-06-24" version="1">MTRIVIIGGGPGGYEAALVGAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIVVADDTPPIEQAARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGKLGGPQGIDGTRDVIVTAADGTETILTADAVLIATGGTPREIPDAMPDGERILNWTQVYDLEELPEELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVIGRSRAESAKRVGDRVEVTLSDGRVISGTHCLMAVGAIPNTKDMNLEESGVRLKESGHIWTDKVSRTSSPGVYAAGDVTGVFALASVAAMQGRIAMYHFLGDAVAPLNLKTVSSNVFTDPEIATVGYTQADVDAGKIDARVVKLPLLRNPRAKMQGIRDGFVKLFCRPGTGIVVGGVVVSPRASELIHPISIAVDNNLTVEQIANAFTVYPSLSGSIAEVARQLHTRKTAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J734</accession>
    <name>A0A0F4J734_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000632">
        <property type="protein sequence ID" value="KJY29583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949392.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000632.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29583">
        <property type="protein sequence ID" value="KJY29583"/>
        <property type="gene ID" value="VR44_22505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.391"/>
    <dbReference type="eggNOG" id="ENOG5033R0Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="15926" checksum="44A1D80A54B57CF3" modified="2015-06-24" version="1">MGVTYKYFGAPDGATAARVPVTMRPEELGGDELGMGGMFTKIKPETMAAMVLTGIEGIPLHKVPPLELVVLHPDYAVVKLPMTVVDPLRDVGEESVGAAAFIWSTVPDRGGPRDAFNVYQLLHEWQDFSHRLHENGHQAYCLVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7V9</accession>
    <name>A0A0F4J7V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000562">
        <property type="protein sequence ID" value="KJY30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30462">
        <property type="protein sequence ID" value="KJY30462"/>
        <property type="gene ID" value="VR44_20440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8798"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22416" checksum="D7312762B942EAFD" modified="2015-06-24" version="1" fragment="single">EVQRLADRCVGRLRASGHSGRTIVLKVRRYDFSTLTRSETLRGPTDDPAVVREAAARLLEGVDTTGGVRLLGVGVSGLADYTQEDLFAQALGAVAQEAGAAPPDGVREAEETDGVTGAAVASGISGALGAPGPAETAVAPVEDQPQAAARHWPAGSDVRHALYGPGWVQGSGVGRVTVRFEQPGSPPGRVRTFLLDDPELEASDPLPLVGRPDASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8H0</accession>
    <name>A0A0F4J8H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_21250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949144.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000591.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5506"/>
    <dbReference type="EnsemblBacteria" id="KJY30084">
        <property type="protein sequence ID" value="KJY30084"/>
        <property type="gene ID" value="VR44_21250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8974"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="119"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="513"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY30084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="587" mass="61696" checksum="4D4B5B40E42E83D7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8V6</accession>
    <name>A0A0F4J8V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000646">
        <property type="protein sequence ID" value="KJY29391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949486.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000646.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29391">
        <property type="protein sequence ID" value="KJY29391"/>
        <property type="gene ID" value="VR44_23060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.551"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="18627" checksum="D9BE0DB2511922F6" modified="2015-06-24" version="1" fragment="single">MTEPQSKPFLYVVVCAAGIAGDVGRLITAAQERGWEVGVTATPHGLEFLDTRAIEEQTGYPVRSAWRSPGEARTHPRADAIAVAPATFNTVNKWAAGFADNLALGILCEAPGMGIPTVLVPYVNTALAAHRAYRRSIDELREMGVLIGSYEPHRPKSGGGSDRFPWEEAVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J900</accession>
    <name>A0A0F4J900_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000581">
        <property type="protein sequence ID" value="KJY30233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30233">
        <property type="protein sequence ID" value="KJY30233"/>
        <property type="gene ID" value="VR44_20935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8917"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008634">
        <property type="entry name" value="Gas-vesicle_GvpO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05800">
        <property type="entry name" value="GvpO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028743">
        <property type="entry name" value="GvpO_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10722" checksum="A6B46FD3D7B8CD0C" modified="2015-06-24" version="1">MATRRPAHRRGAPGAAAVLRAAAEQLAELLGRPPDSVSSVKPTEDGWEAVVEVVELERIPDTTSVMGSYTVALDAEGELISYERTRRYSRGMVDRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9D8</accession>
    <name>A0A0F4J9D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000526">
        <property type="protein sequence ID" value="KJY30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948763.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000526.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30967">
        <property type="protein sequence ID" value="KJY30967"/>
        <property type="gene ID" value="VR44_19165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8439"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="139" mass="15270" checksum="8EB742B3F4D2E721" modified="2015-06-24" version="1">MDLTVVAYVIYLVISIGLTVWVARTLSRNGRIFIADVLQGNEKLAEAVNHLLVVGFYLVNIGFVTLYLRSADTILEARGLFEALSVKLGVVLLVLGVMHLGNVWVLNRMRRRGIMERQAPQLPPVPPLPPQGWTAPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9R5</accession>
    <name>A0A0F4J9R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000557">
        <property type="protein sequence ID" value="KJY30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948952.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000557.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30544">
        <property type="protein sequence ID" value="KJY30544"/>
        <property type="gene ID" value="VR44_20205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="91"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="29108" checksum="D4E4DB40DF12028A" modified="2015-06-24" version="1" fragment="single">MNQEDRTPEDAYAQPDGDVYEDEAEATRREAGEAESSRASRGWWDRNADEYQSEHGAFLGDDRFVWGPEGLDEEQAALLGPAASLKGRDVLEIGAGAAQCSRWLAAQGARPVALDLSHRQLQHALRIGGGVPLVEADAGRLPFRDGSFDLACSAYGAVPFVADPVNVMREVHRVLRPGGRWVFSVTHPLRWAFPDEPGPEGLSVSASYFDRTPYVEQDEQGRAVYVEHHRTLGDRVRDVVAGGFRLLDLVEPEWPEWNTQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA51</accession>
    <name>A0A0F4JA51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948652.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7333"/>
    <dbReference type="EnsemblBacteria" id="KJY31247">
        <property type="protein sequence ID" value="KJY31247"/>
        <property type="gene ID" value="VR44_18575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8310"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="460" mass="49379" checksum="2D4F1DB089970F35" modified="2015-06-24" version="1">MAARPLVARQPNERLQALIQEAGCSNAGLARRVNMCGAEHGLDLRYDKTSVARWLRGQQPRGRAPGIIAEALGRKLGRTVTIDEIGMANGKNLASGVGLQFSPTVVGAIEQVCELWRSDVGRRDFLSGSSVAASALVEPSRDWLITGADPQVARNGGSRVGMSDVEAVRATTQALTDLDHRFGSGHVRPVVVHYLNSVVSGLIGGSYREPVGRALFAAVARLTELAGYMAVDTGQPGLAQRYYIQALRLAQAAGDRAYGGYVLAASMSHLAAELGNPREIAQLARAAQEGTRGQVTPRVEAMFYAAEARGHALLGDARSTAVLSGRAVTALERAEPESGDDPVWIRHFDQAYLADELAHCHRDLGQADAAGKRAEEALRGLPVTKARRRAIGLLLLAAAQVQQREVEQACQTAAKAAELLGTLRSRRGAEYLDDFRARLEPYREEPAVREFGARLEVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA70</accession>
    <name>A0A0F4JA70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000550">
        <property type="protein sequence ID" value="KJY30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948909.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000550.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30643">
        <property type="protein sequence ID" value="KJY30643"/>
        <property type="gene ID" value="VR44_19970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8615"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23122" checksum="E38819894967D0A5" modified="2015-06-24" version="1">MSASTASAHVVLTARALLLDMDGTLVDSDAVVERCWREWALSHGLDPQEALKVVHGRQGYATMAILLPERPMELNHAENAEMLARETADTEGVVPVAGAPEFMAAIARLPHALVTSADAALAGVRMTAAALPMPGVRITAESVGASKPDPEGFLKGAAELGVDPADCVVFEDSGAGIAAGLAAGMRVIGIGPRAAAHGPTAHVDDLTAVRVEAGEDGSIRLTLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA76</accession>
    <name>A0A0F4JA76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000518">
        <property type="protein sequence ID" value="KJY31085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948714.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000518.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31085">
        <property type="protein sequence ID" value="KJY31085"/>
        <property type="gene ID" value="VR44_18895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8319"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="21277" checksum="396357191B722BDF" modified="2015-06-24" version="1">MALRHAVLAALLDDEYSGYQLAKAFDISVANFWHALPQQLYAELARLEADGLVVGREVVQETRPNKRLFRVTEAGRAELERFAEAASKPSSIRDDLLVKVQTADRVGTGPVIEQLEQRAAAAGAKLELLGKLLDNMRGDTDEAEYLLRGERVGRYLTCLRGLAFEREHRDWCLRTAAVLRERQQTDAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA93</accession>
    <name>A0A0F4JA93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000502">
        <property type="protein sequence ID" value="KJY31287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948627.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000502.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7347"/>
    <dbReference type="EnsemblBacteria" id="KJY31287">
        <property type="protein sequence ID" value="KJY31287"/>
        <property type="gene ID" value="VR44_18450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8285"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="272"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="532" mass="56942" checksum="83F374854E9234B0" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAI4</accession>
    <name>A0A0F4JAI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949205.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29961">
        <property type="protein sequence ID" value="KJY29961"/>
        <property type="gene ID" value="VR44_21560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.190"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="115" mass="12443" checksum="81AD144ACCA9F90F" modified="2015-06-24" version="1">MDAVPLLDWGDSSHFDARATRPCCLCGKPTPMRSHADEAVHKVCAEEWNAAHPDEPRRYTPPAPGRTQHDVGTWRFHNDGPTTPYLRRPTAATRALAQSPAAPGMAGGQDGLFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAM9</accession>
    <name>A0A0F4JAM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30864">
        <property type="protein sequence ID" value="KJY30864"/>
        <property type="gene ID" value="VR44_19315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8470"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="17771" checksum="F1CB017D075B7DF2" modified="2015-06-24" version="1">MTPQPPGPAGAPRAVPQPNAVVGVGLIVLGPDGRVLLGQAHDGRWELPGGKVDPGEGFEQAAARELAEETALRTTPEAVEVLAVQIAAAETGLTRLTAAALTRSAEGTPAVTEPHKIAQWRWFAPEEIPAALYAPSAAVLRAWNPGLTTLPEVPCHDYTTRPTDTSPENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAY7</accession>
    <name>A0A0F4JAY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ORF">VR44_17985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000486">
        <property type="protein sequence ID" value="KJY31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948537.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5647"/>
    <dbReference type="EnsemblBacteria" id="KJY31517">
        <property type="protein sequence ID" value="KJY31517"/>
        <property type="gene ID" value="VR44_17985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8142"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="634" mass="69542" checksum="9C1D39CCE41E9247" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBL3</accession>
    <name>A0A0F4JBL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4124"/>
    <dbReference type="EnsemblBacteria" id="KJY31128">
        <property type="protein sequence ID" value="KJY31128"/>
        <property type="gene ID" value="VR44_18800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KdpD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="34273" checksum="AC005D0596062222" modified="2015-06-24" version="1" fragment="single">MGRGRLRIYLGAAPGVGKTYAMLSEGHRRVERGGDVVVGFVEHHGRPRTEVMLHGLEQVPRRELVHRGASFTEMDVDAVLARRPAVALVDELAHTNVPGSRNAKRWQDVEELLRAGIDVVTTVNIQHLESLGDVVETITGVRQRETVPDEVVRRADQVELVDMSPQALRRRMAHGNIYQPDKVDAALSNYFRPGNLTALRELALLWVADRADEYLQQYRGEHGIRSTWQARERIVVGLTGGPEGRTLIRRASRMAAKSSGSEILAVYIARSDGLTSASPKELAVQRTLVEDLGGTFHHVIGDNVPEALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC09</accession>
    <name>A0A0F4JC09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000561">
        <property type="protein sequence ID" value="KJY30491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30491">
        <property type="protein sequence ID" value="KJY30491"/>
        <property type="gene ID" value="VR44_20340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8777"/>
    <dbReference type="eggNOG" id="COG1718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="30764" checksum="B1CB6D3B5BB74B4B" modified="2015-06-24" version="1">MSEVIATRYVTPLREGGSLPGIVEADDLGTYVMKFTGAGQGRKTLVAEVVCGRLAQRLGLRVPRLVQMQLDPVIGLAEPDQEVQELLKASGGLNLGMDYLPGSIGFDPLAYRADPVEAGRVVWFDALINNVDRSWRNPNMLVWHGDLWLIDHGATMIWHHNWPTAQAAAAKPYNASDHVLAPVGPDIEAAAAELSPLVTEELLTEVAADVPDEWLVDEPGFDSADAVRRAYVAALLPRAATIHERITMEAEVRQQSGPPGWLAERLPPQSDKNKNKQKSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC50</accession>
    <name>A0A0F4JC50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000500">
        <property type="protein sequence ID" value="KJY31328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31328">
        <property type="protein sequence ID" value="KJY31328"/>
        <property type="gene ID" value="VR44_18395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8228"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="6191" checksum="DC0074764DFD9206" modified="2015-06-24" version="1" fragment="single">PGSQTPAPGTGLLGGTGDLLHPPAQGQSTPAAPVAPGLPQPDITIPPLLPNLLPGLGIKAEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDC1</accession>
    <name>A0A0F4JDC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000527">
        <property type="protein sequence ID" value="KJY30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948782.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000527.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30951">
        <property type="protein sequence ID" value="KJY30951"/>
        <property type="gene ID" value="VR44_19200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8446"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="3">
        <location>
            <begin position="60"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="40987" checksum="766C139C8D74C9D7" modified="2015-06-24" version="1">MLVPPSTARAATAPPRPPDGKGKPQAPAPPPSMSTVGGSRLGQPGTQVNLMPGAPELPANLSGRSWIVADAETGEVLAAHNAHWRLPPASTMKMLFADTVLPTLPKDQVHHVTDQDMDGVGPGSSLVGVKEDHDYTVHDLWLGVFLRSGNDAVHVLSAMNGGVEKTVKDMQAHAEELQALDTHVVSPDGYDAPEQVSSAYDLTLIARSGLQKQDFREYCGTAEAKFPGHQEAGRPREYFEIQNTNRLMTGAGGVTPYKGIAGVKNGNTTMAGSTFTGAAQRGNKKLLVTVMNPDHGGLNSVYEETADLFDWGFAAAGKVKPVGVLVPPKGTDTEPYGSPAKSHENTPVADGPPPAGGGGLGTALGIAGGALAVVAGGAFVVNRRWPRGRRGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDH2</accession>
    <name>A0A0F4JDH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_16280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000424">
        <property type="protein sequence ID" value="KJY32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32255">
        <property type="protein sequence ID" value="KJY32255"/>
        <property type="gene ID" value="VR44_16280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7709"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="10852" checksum="D401109FD4021A57" modified="2015-06-24" version="1" fragment="single">LSAAPAALRGLGPDRLAALAELAEVIGWILFDAGRYRRAHRMNARALALADLCGDRWTARLTLLNHSMLTTHTGRPRAALAAAARAAAGPRPLPARVAGLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE21</accession>
    <name>A0A0F4JE21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS sugar transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_17015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948356.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7010"/>
    <dbReference type="EnsemblBacteria" id="KJY31988">
        <property type="protein sequence ID" value="KJY31988"/>
        <property type="gene ID" value="VR44_17015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7932"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="13"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY31988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="418" mass="43953" checksum="A236E3E4C66FEEA1" modified="2015-06-24" version="1">MSTATAAEKKKGAGVMAVMQRIGRSLMLPVAVLPAAALLVRLGDKDMLGSASMPEFINKIAGYMSAGGGAILDNMALLFAVGIAIGYAKKSDGSTALAAVTGYLVFKNVLATFTDSNLPKIAKVVDGKVAMVEAPVDAKVLGGVVMGLVVALIYQKFYRTKLPEWAGFFGGRRLVPILSAFAGLLIGIVFGLIWPVLGTGLHNFGEWLVGSGAVGAGIFGVANRGLIAVGMHHLLNSFPWFQAGEYNGKSGDIARFLAGDPSAGQFMTGFFPIMMFALPAACLAIVHCARPERRKVVGGMMFSLALTSFVTGVTEPIEFTFMFIAPVLYAVHAVLTGVSMALTWALGMKDGFGFSAGAIDYLLNLGKATNPAGLALVGLCFAALYYVIFRFAITKWNLPTPGRESDEELAELAKAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEV3</accession>
    <name>A0A0F4JEV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">VR44_15085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000386">
        <property type="protein sequence ID" value="KJY32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32882">
        <property type="protein sequence ID" value="KJY32882"/>
        <property type="gene ID" value="VR44_15085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7435"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="59"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="37299" checksum="FA4D21848FF3A5DC" modified="2015-06-24" version="1">MEEVAAVARPVWAGNLSFGLVSLPVGLYTATDSHTIHFHQLQRGTSDRIRNRRVNERTGKEVELEDIVKGFDTGDEYVLIEPKELEEIAPGRSRSLEIRGFVDLAEVDPIFFDKTYYLGPRGAEFGKVYSLLEQALARAGKAGIATFVMRQHEYLVALKSENGLLTLHTLHWADEIRDPKKEIGTLPGKAEAKASEKELKMAEQLIRAMSMDWDPEQFHDTFQEKVAALIEAKKAGETVEKAEPAAEPTGVVDLMDALRASIERAGSPKATGGKATASGRAPASSKAAAKKPAAKKRIRSAPKEDLAGLTKADLYKKAAAANLPGRSHMSRDDLVQALSSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG46</accession>
    <name>A0A0F4JG46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">VR44_14140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="JZWV01000364">
        <property type="protein sequence ID" value="KJY33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947830.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3371"/>
    <dbReference type="EnsemblBacteria" id="KJY33327">
        <property type="protein sequence ID" value="KJY33327"/>
        <property type="gene ID" value="VR44_14140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7174"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="20720" checksum="A7686CCC1588DE18" modified="2015-06-24" version="1">MAAEVRPRLTVLSGPSGVGKSTVVAHMRKVHPEVWLSVSATTRKPRPGERHGVQYFFVNDDEFDKLIANGELLEWAEFAGNRYGTPRGAVLERLDNGEPVLLEIDLQGARLVRESMPEAQLVFLAPPSWDELVRRLTGRGTETAEVIERRLGTAKVELAAESEFDTTLVNTSVEDVARELLALMEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGB5</accession>
    <name>A0A0F4JGB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000449">
        <property type="protein sequence ID" value="KJY31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948359.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000449.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31991">
        <property type="protein sequence ID" value="KJY31991"/>
        <property type="gene ID" value="VR44_17030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7936"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="117" mass="12708" checksum="E561F6B2621C1290" modified="2015-06-24" version="1">MSGRGVRLRRVYDPPEPGADGVRVLVDRLWPRGLSKEAAAVDQWPKALAPSTELRKWFHGGGSAEEFRRRYEAELAGAGAELDRLRDLAASGPLTLLTAVRDPASSHAAILAEHLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGF0</accession>
    <name>A0A0F4JGF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000447">
        <property type="protein sequence ID" value="KJY32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948335.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000447.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32031">
        <property type="protein sequence ID" value="KJY32031"/>
        <property type="gene ID" value="VR44_16900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7816"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470518" evidence="3">
        <location>
            <begin position="42"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="439" mass="45437" checksum="7DB80528583C96B4" modified="2015-06-24" version="1">MGVRGRHRRYQPSSINRASLVVTAGGAGIALPLIGAGDAQAAAVDTWNKVAACESTSNWQTNTGNGYYGGLQFSQSTWREFGGTAYAPRADLATKDQQIAVAEKVLRGQGPKAWPACGPQAGLSRSAAAPAGEAEPAAKPAVKPAAKPQAQAPMDRIQPTKATTATPVSMPRPTGTTVLPNPYVVAPGDSLSSIASQQHVEGGWQALYETNRETVGGNPNMIFPGQRLTLRITAAPAPPAQNPEKPPRTAEPVKPGEPAKQQDAKPETKPQAKPESKPKPEQAAKPAQPAKPAEKPASAEQKPASGGFTAPVDADLGTAYHVAGSSWSSGYHTGVDFPVPTGTSIKAVGPGTVESAGWAGAYGYQVVIKHADGRYSQYAHLSALGVKAGQQVSGGQRIGRSGSTGNTTGPHLHFEMRTSPAYGSDIDPLKYLRGKGVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGL0</accession>
    <name>A0A0F4JGL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable M18 family aminopeptidase 2</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">apeB</name>
        <name evidence="12" type="ORF">VR44_13890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947785.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6080"/>
    <dbReference type="EnsemblBacteria" id="KJY33467">
        <property type="protein sequence ID" value="KJY33467"/>
        <property type="gene ID" value="VR44_13890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7063"/>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00467">
        <property type="entry name" value="Aminopeptidase_M18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022984">
        <property type="entry name" value="M18_aminopeptidase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="430" mass="46013" checksum="3F28B59E27158CBD" modified="2015-06-24" version="1">MSSPARFDRGHTDDLMTFLTASPSPYHAVANAAERLEKAGFRQLSESDAWDSGTGGRFVLRGGALIAWYVPEGAAAHTPFRIIGAHTDSPNLRVKPVPDTGSQGWRQVAVEIYGGTLLNTWLDRDLGLAGRLSLRDGTDRLVNIDRPLLRVPQLAVHLDRSVNTDGLKLDKQRHMQPIWGLGEAREGDLIAFLEEEEGLPQGSVAGWDLMVHSIEPPAYLGRDRELLAGPRMDNLVSVHAGVAALAAVSASGKLDHIPVLAAFDHEENGSQSDTGADGPLLGNVLERSVFSRGGTYEDKARAFAGTICLSSDTGHAVHPNYAERHDPSHHPRANGGPILKVNVNQRYATDGSGRAVFAAACERAGVPWQTFVSNNSMPCGTTIGPITAARHGIQTVDIGVAILSMHSARELCGSDDPFLLANALLSFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHF4</accession>
    <name>A0A0F4JHF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_16075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000414">
        <property type="protein sequence ID" value="KJY32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948180.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000414.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32401">
        <property type="protein sequence ID" value="KJY32401"/>
        <property type="gene ID" value="VR44_16075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7636"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="29416" checksum="100649A428A517AC" modified="2015-06-24" version="1">MPTERTSSGDPAHTLQLLWRGSSPDRRRGPRRGLSIDAVVEAANAIADAEGLDAVTMRRVAKELGVVPMTLYTYVPGKAELLDLMLDTAYARMPRTDTTGQPWRQRVTAVAEENKALFERHPWAAAVSTVRPPLGPGQMSKYEHELSALDGLGLSDVEMDDCLTHLLTFVQACARAVADARAAQHDSALNDQQWWELNAPLLARVLDENAYPTAVRVGAAAGAAHNSAYDPAHAYSFGLQRVLDAFAALIDRSRDAKTSTSQHRHDDIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI72</accession>
    <name>A0A0F4JI72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34042">
        <property type="protein sequence ID" value="KJY34042"/>
        <property type="gene ID" value="VR44_12715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6623"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="327" mass="34613" checksum="9E664D713E3AC075" modified="2015-06-24" version="1">MVLLTASHRVAPGLLSWPAWQALHAADRVLCADPGHPQLPYLREAGVVVAHEAPDAHALVDACAGGRTIVVIPGGEGDQRLTDGLARLAGSGRVAMPDLELLPGSYDLPGARLLDLVQVMDRVRRDCPWTSRQTHEGLVKYAIEEAYELVEAIEDGDRDALREELGDVLLQVVFHARIAEEGTQDAEDAEDAEGSGGSGAFSIDDVAGDLVAKLIRRHPHVFGDATAESPEDVSAHWQATKAVEKQRESVTDGIPLAQPGLALAAKLAGRARAGGVPVELPRGEGIGYELLELAARAEAEGTDPETALRAAARVYRDAIRAAEGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIM7</accession>
    <name>A0A0F4JIM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000306">
        <property type="protein sequence ID" value="KJY34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947505.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000306.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34202">
        <property type="protein sequence ID" value="KJY34202"/>
        <property type="gene ID" value="VR44_12375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6461"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="148"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="285" mass="28742" checksum="4413BD5CF22178CC" modified="2015-06-24" version="1">MTGAAAVPAAVLASAVLHAVWNGLAHGLRDKLAGFTLISLASAGCGAVLACLAPLPAPAAWPYIAASAALQAAYQLLLLRAYQLGDFGQMYPTARGTSPLVVALVSTTLLGHSLPVGRAMGIAVISCGLAALALADGMPGRAQLPALAAALGTGVMIASYTLVDGSGVRVSGSVFGYVAWLFLCQGLVLPVIAWARRGPALLTTLRPLCGRGLAGGLLSLLAYGLVVWAQSRGDLSTIAALRETSIVFGALIGAVVFRERLGHRRITASVTVLAGIAVLQLAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIM8</accession>
    <name>A0A0F4JIM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_15210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000392">
        <property type="protein sequence ID" value="KJY32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32821">
        <property type="protein sequence ID" value="KJY32821"/>
        <property type="gene ID" value="VR44_15210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="10844" checksum="E3A2E65283532870" modified="2015-06-24" version="1" fragment="single">PLPYLDALWAVAREAAERAGRDPAALRRVFRVNAHVTTAEADPAETHQRGTVRQICDHLRTMCRADTDEVLVDLQLTTDSPEEFLDLAARFTAELTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIQ6</accession>
    <name>A0A0F4JIQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000316">
        <property type="protein sequence ID" value="KJY34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34065">
        <property type="protein sequence ID" value="KJY34065"/>
        <property type="gene ID" value="VR44_12655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6610"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="8329" checksum="178706B1F8291C02" modified="2015-06-24" version="1" fragment="single">GNLDSRAGAEVLGFLRQSVDELAQTIVMVTHDPVAASYADRVIFLADGRIVDEMYAPTADQVLDRMKDFDARGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJG9</accession>
    <name>A0A0F4JJG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000286">
        <property type="protein sequence ID" value="KJY34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34477">
        <property type="protein sequence ID" value="KJY34477"/>
        <property type="gene ID" value="VR44_11785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="267" mass="28176" checksum="D835B2C7545F43BA" modified="2015-06-24" version="1" fragment="single">GPLPPDRLTPAETRLAVLWEEQLGIRPGPGDDFFALGGTSLGAARLASALRAGHPGISVADLYRRPVLRDMAAHAETLVARRDPRPPVRPVPRRAGLVQLLTQTASYTVTGLRGVVLLTGVDNVLGLLAPHTWTPYTPWWLVLTGWLALFAAPSRFALGTLAARLLTRGVRPGVHPRGGPVHLRLWAAERAVSVFGVPDLLGTPWAARYARALGCATGPGAALHAMPPVTGLAEFGAGCAVEPEADVRGWWLDGDRLVVGAVRIGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK82</accession>
    <name>A0A0F4JK82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34178">
        <property type="protein sequence ID" value="KJY34178"/>
        <property type="gene ID" value="VR44_12415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6542"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="28341" checksum="B8F156D1D2A0047C" modified="2015-06-24" version="1">MADVIEVAGNELRFLRRMIGDVGENVWERLLEWLIDDWFRLDVLGLENIPADGPAVLVANHSGAWGLDAFVLQKILVRSLRRSLHVLAAPFVFRIPVLGPHAAKMGAVPVDQRAAMRRLAEGGLVAVFPEGLSGLEKPFRERYRLQPFNPGFAVAALHTGAPIVPVTVIGAEESSPRIGEVPALARFLDLPYFPLTSPFPLPAKWLITIGEPIAPPERPRGFGERAEAARRLCADVQSALQDMVERERERRDSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKE3</accession>
    <name>A0A0F4JKE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000299">
        <property type="protein sequence ID" value="KJY34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947464.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000299.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000024_gene6467"/>
    <dbReference type="EnsemblBacteria" id="KJY34294">
        <property type="protein sequence ID" value="KJY34294"/>
        <property type="gene ID" value="VR44_12155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6411"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="24416" checksum="FFC62C737D99A242" modified="2015-06-24" version="1">MTENRVLPGLRVVLTDVNERVVQAWRAAFADTPGIEIRRGSILDEDVDAWVTPTNSRGRMDGGVDAVIKRHLGAGIQLRVQRAIRDRFAGTLPVGSAVCVPSGATVPRYLISTPTMVESSQNVRDTLNVALACAAAFQAVHRQNRRAPDSIRSVALVGMGAQTGRVPARVCANLMWTGCTLFQDHWFEDDDELRATITAQLDGIEKAPAAERVRIVPPKGHSFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKP3</accession>
    <name>A0A0F4JKP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CBS domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000263">
        <property type="protein sequence ID" value="KJY34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34760">
        <property type="protein sequence ID" value="KJY34760"/>
        <property type="gene ID" value="VR44_11345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6164"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="37" mass="3980" checksum="2FFE7813DE8D380E" modified="2015-06-24" version="1" fragment="single">FVTTMAEAEHATRHRRLDVLPVVDDHGGAPGVLALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLJ1</accession>
    <name>A0A0F4JLJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein VR44_10910</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000245">
        <property type="protein sequence ID" value="KJY35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947230.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000245.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35050">
        <property type="protein sequence ID" value="KJY35050"/>
        <property type="gene ID" value="VR44_10910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6062"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6464" checksum="10227F6F70911EA1" modified="2015-06-24" version="1">MPLEAGLLEILACPACHAPFQDNSADETTPELVCTGQDCGLAYPVRDGIPVLLVDEARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM49</accession>
    <name>A0A0F4JM49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000320">
        <property type="protein sequence ID" value="KJY34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34006">
        <property type="protein sequence ID" value="KJY34006"/>
        <property type="gene ID" value="VR44_12830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6648"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="44"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="279"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="429" mass="44345" checksum="EF67C892FCEBF0CC" modified="2015-06-24" version="1">MRAAVEQGLLDSEPLVCLLDTAGIRASAAALTGAFAAATAPGTPVLHAFAAKASPLVPVLRLLADCGLGCEVASAGELALARAAGIPAERIVLDSPAKTTGELREALALGITVNADNHQELERLDALIAAAPTRSPIGVRVNPQTGAGAIDALSTATATSKFGIGLRDPGARERLVRACLDRPWITRLHAHSGSQGLPLPLIARGVRELHALAEEINAAAGRRQVDTLDIGGGLPVNFASDEETPTYAEYADALREAVPALFDGSYGLVTEFGRSLLAKHGTVLARVEYTKATGGRPIALTHAGVQVATRTVYAPAAWPLRILPYDAKGLPKTGPPVAQDVAGPACFAGDLLATARDLPELAPGDLIAVPDTGAYFFTAHYGYNSLPRPPVHGFTADPPGPVRFTPVRPAQTTTEIVAESGGALRDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMS0</accession>
    <name>A0A0F4JMS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_09510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35662">
        <property type="protein sequence ID" value="KJY35662"/>
        <property type="gene ID" value="VR44_09510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5303"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="44610" checksum="4E0ED83CEFB538AE" modified="2015-06-24" version="1">MSIASGARAGARWALVAVLAANMLVDALEVSATLVALPAVGSGLGAAVTRVQWIVTGFAAGFGGALLLGGRVVEWFGRRRVFLAALLVFAAVSLGGALTDRLDLLVATRVVKGFCVALTAPTGLAIIVASVPAGAARRRAVSVYSLFGAAGFCSGLLLSGLLTGAAGWRWTLAFPAFVVSALFAVALRVVPREPGVPGGGARWRAVVAGGALTSAVLLLVDALASWRWGSAGAAAVAVLVCVRAERASPRPLVNTALLRHAPLVRSALGAAALNGSYVSFLLVAALDLRRGGWSAWETALGFLPAGAPLALTALHSGRIAARLGPARAVAAGALAAPAGYALYPRSGAGGAQYVELLPSMSLVGLAFVLAFTALHLQATGSLPSGLQTAAGGLYQTCVQLGAALTPALTAALYAASGRSAALWLVTAVGVAGAGVALAGLAHPSNDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNS0</accession>
    <name>A0A0F4JNS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_10185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000221">
        <property type="protein sequence ID" value="KJY35469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3204"/>
    <dbReference type="EnsemblBacteria" id="KJY35469">
        <property type="protein sequence ID" value="KJY35469"/>
        <property type="gene ID" value="VR44_10185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5637"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="3">
        <location>
            <begin position="303"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="396"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="532" mass="58390" checksum="664A828E85760C2C" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNT7</accession>
    <name>A0A0F4JNT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_08995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000192">
        <property type="protein sequence ID" value="KJY35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946878.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000192.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2373"/>
    <dbReference type="EnsemblBacteria" id="KJY35870">
        <property type="protein sequence ID" value="KJY35870"/>
        <property type="gene ID" value="VR44_08995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4971"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="7"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="454" mass="48297" checksum="7D5D9A9828D03E88" modified="2015-06-24" version="1" fragment="single">KSLKPRHVNMIAIGGAIGTGLFLGAGGRLADAGPSLFVAYAVCGIFAFLVVRALGELVLYRPSSGAFVSYAREFLGEKGAYTAGWMYFLNWATTGIADITAVATYTHYWHLFSDVPQWVIALIALAVVLTVNLISVRIFGELEFWFAIVKVSALVVFMGIAIFLLVTRHPVGGTVPGPALITDHGGIFPNGLLPMLLIIQGVVFAYASVELVGVTAGETENPEEIMPKAINSIMWRVGLFYVGSVILLSMLMPWNSYSAGQSPFVTVLSHIGIPAAGDVMNLVVLTAAMSSLNSGLYSTGRILRSMAVNGSAPRFTARLSRTQVPYGGILLTSGMCVLGVGLNFVVPADAFEIVLNLAAIGILATWGMIMICHLLFWRKTRSGELTRPSYRLPGSPWTEIVTLAFLASVLVLMYADGGAARTTVLCVPLIAAALVAGWYAVRGRVARAASGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPR8</accession>
    <name>A0A0F4JPR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">VR44_08415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000173">
        <property type="protein sequence ID" value="KJY36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946765.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000173.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5016"/>
    <dbReference type="EnsemblBacteria" id="KJY36180">
        <property type="protein sequence ID" value="KJY36180"/>
        <property type="gene ID" value="VR44_08415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4583"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="30209" checksum="A3B910C53B49B84D" modified="2015-06-24" version="1">MTHAVSPAREAASPTLYGGTGTRRITVRDLTLAKERGEKWPMLTAYDAMTASVFDEAGIPVILVGDSMGNCHLGYETTVPVTMDEMTLLSAAVVRGTSRALVVGDLPFGSYQEGAVQALRSATRLVKEAGVHAVKLEGGERSLHQTELIVQSGIPVMSHLGLTPQSVNAMGYRVQGRGDEAAHQLLRDAKAAQDAGAFAVVLELVPAELAAEVTRSLHIPTVGIGAGAECDAQVLVWTDMMGLTGGKMPRFVKQYANLRATMGDAAKAFAEDVVGGSFPQPEHAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPZ3</accession>
    <name>A0A0F4JPZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947243.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34986">
        <property type="protein sequence ID" value="KJY34986"/>
        <property type="gene ID" value="VR44_10990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6082"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="159" mass="16514" checksum="287DEFA9D10EE85A" modified="2015-06-24" version="1">MLLADVRMAVPGDAAAISRLLAAAIREDYDSLLGEMRVGRLLSDHCSLPRIRAEIGIPGGAPAWLGWLVATDADGTVVGAVSGGVPVTSEGELYALCTTPGRRRQGVGSALLAAAGERMRTHGAVSQRITLPAESTPALSFFARHGFTALTPVRLGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR75</accession>
    <name>A0A0F4JR75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_07440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946579.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2249"/>
    <dbReference type="EnsemblBacteria" id="KJY36690">
        <property type="protein sequence ID" value="KJY36690"/>
        <property type="gene ID" value="VR44_07440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3961"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="277" mass="29659" checksum="39ACC98D0863C009" modified="2015-06-24" version="1">MVNAEIGVIGGSGFYSFLEDVSEVQVETPYGPPSDSLYLGELAGRQVAFLPRHGRSHTVPPHKINYRANLWALRSVGVRQVLGPCAVGGLRAEYGPGTLLVPDQLVDRTKSRVQTFFDGEPLPDGSVPNVVHTTFADPYCPVGRSVALSAARGREWEPVDGGTMVVVEGPRFSTRAESQWHAAAGWSVVGMTGHPEAVLARELGLCYTSMALVTDLDAGAETGEGVSHAEVLKVFGENVSRLREVLFDAVAALPATEDRDCLCTHAHDGWDLGIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRD8</accession>
    <name>A0A0F4JRD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000219">
        <property type="protein sequence ID" value="KJY35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042814566.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3211"/>
    <dbReference type="EnsemblBacteria" id="KJY35481">
        <property type="protein sequence ID" value="KJY35481"/>
        <property type="gene ID" value="VR44_10140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5628"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="32570" checksum="4660BFE29E61D029" modified="2015-06-24" version="1">MSEPTGAARRRGPFEVGDQVQLTDPKGRHYTFTLEAGKNFHTHKGSFPHDELIGAPEGSVVRTTGNVAYLALRPLLPDYVLSMPRGAAVVYPKDAGQILAFADIFPGARVVEAGVGSGSLSSFLLRAIGDQGMLHSYERRADFAEIATANVERYFGGPHPAWKLTVGDLQDNLDETDVDRVILDMLAPWECLEAVKKALVPGGILCCYVATTTQLSKTVESIREIGCFAEPQPWESMIRNWHVEGLAVRPDHRMIGHTGFLVTARRLADGVEPPMRRRRPAKGAYGEDYEGPGSDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRW1</accession>
    <name>A0A0F4JRW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37102">
        <property type="protein sequence ID" value="KJY37102"/>
        <property type="gene ID" value="VR44_06560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3228"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="208" mass="22228" checksum="7006A7C00A9B0C4E" modified="2015-06-24" version="1">MPTEPSLILNGPELGTYFDSFHGPGAAPGSLGPWVRVKPNTVYRIQVAAFNADRQAGPRSEILTVDTTPHDPPGLVDSLVDPDPPNDFRLVSMPDYKAPAPALVVSWKPSRLATAYELYANTQTSGTATMDPSRPGLMRGDTLAATVPQPSDPNAVITYSVNNPPQDTPYVLKVRAKRTATVEGIEETKTSPFAPEVRTRTSTASTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSF4</accession>
    <name>A0A0F4JSF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946577.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36688">
        <property type="protein sequence ID" value="KJY36688"/>
        <property type="gene ID" value="VR44_07420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3957"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8010" checksum="87A5DBC30887CC05" modified="2015-06-24" version="1">MSTAPASDPQSPEPTVGAKPEPTPTPKPRPKLVFDDPLDQQSSDDTDRGWGERPPAGGSAADLARFLDEKPPHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTJ6</accession>
    <name>A0A0F4JTJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37154">
        <property type="protein sequence ID" value="KJY37154"/>
        <property type="gene ID" value="VR44_06430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3198"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9585" checksum="4A69A4F19CD38453" modified="2015-06-24" version="1">MTEKPPIRPKGAGIEPHDEMCERCGWTYSMACPECPGCGCYTGKCSGWRHGEYGGQDDDAEPYDCGDDECEGCDDCSPYGLAYGQVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTT6</accession>
    <name>A0A0F4JTT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000164">
        <property type="protein sequence ID" value="KJY36391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946718.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000164.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36391">
        <property type="protein sequence ID" value="KJY36391"/>
        <property type="gene ID" value="VR44_08150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4379"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470873" evidence="2">
        <location>
            <begin position="46"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="110"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="556" mass="59705" checksum="5DCF8966B9BC0B7D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTW7</accession>
    <name>A0A0F4JTW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946204.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7135"/>
    <dbReference type="EnsemblBacteria" id="KJY37600">
        <property type="protein sequence ID" value="KJY37600"/>
        <property type="gene ID" value="VR44_05395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1715"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="176" mass="18263" checksum="B36A0C3CC5705B9E" modified="2015-06-24" version="1">MDLTPAPTLTLHVNGRPEEFAARPSELLVERLRDGLGLTGTKVGCDTGQCGTCVVRLDGRSVKSCLVLTASAAGSEVTTIEGVSERGGELTGLQEALRQEHGTQCGFCTPGMVMALGELVENTAAGTAPTEPEIREWLTGNLCRCTGYHSVVRGVQRACAAPADPAVTAVPAAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUW1</accession>
    <name>A0A0F4JUW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_04070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000075">
        <property type="protein sequence ID" value="KJY38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945962.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene732"/>
    <dbReference type="EnsemblBacteria" id="KJY38152">
        <property type="protein sequence ID" value="KJY38152"/>
        <property type="gene ID" value="VR44_04070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8719"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="37254" checksum="D0810CF6590F3C2C" modified="2015-06-24" version="1">MNDSPWAAEPVPAGPAYDALVGPQTAPMPIVPDAAGRAFDDREARDRGAAFAGGPPLRTEMPLQEPMPSPPPPPPQAPQDASPPPQKKRAGRDLRAAIGVGVGLGAVIFASLFIVKAVFVGVIVVAVVVGLWELTSRLQEKKGIKAPLVPLAVGGAAMVIAGYVRGAEGAWVAMALTALAVLVWRMTEPPEDYLKDVTAGVFAAFYVPFLATFVAMLLTAEDGPQRVVTFLLLTVVSDTGAYAVGWRFGKTKLAPRISPGKTREGLFGAVAFAMGAGALCMEFLIDGGSWWQGLLLGLAVAVSATLGDLGESMIKRDLGIKDMGTLLPGHGGIMDRLDSLLPTAPVVWLLLAAFVGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUW9</accession>
    <name>A0A0F4JUW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_04100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000075">
        <property type="protein sequence ID" value="KJY38157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945967.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000075.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38157">
        <property type="protein sequence ID" value="KJY38157"/>
        <property type="gene ID" value="VR44_04100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8725"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="3">
        <location>
            <begin position="344"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY38157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="464" mass="49476" checksum="FDD88346E638A7B6" modified="2015-06-24" version="1">MNSDGALERLKREGRIVVVGASLAGLRAAEKMREKGFAGELTMIGDEPHEPYDRPPLSKQVLLGMATADGTALPRRRDIDAKWRLGVPAAGLDMAASRVRMADGDEVEYDRLLIATGVRARPWPNPEEAALDGVFVLRTRGDAAALERALAAGPGRVLVIGAGFTGSEIASACRERGLAVTVAERADAPLVGALGGVVGAVAADMHRENGVDLRTGIMVTALEGDSSGRVRAAHLSDGTTLEAEVVVVSLGAQRNTEWLAGSGLGAGPRGIACDAGCRAFDIMGIVTDDIYVAGDVARSPHALFGYQFLSLEHWGNAVAQAETAAHNMLSTSAERRPHLWVPAFWSSQFGVNIKSVGVPSMGTEIMITQGSRAERRFVGVYGYQGRVIGAVTFDQCRWLDFYEQQIEQTAPFPPPYPTVDRRPEGERPLPADFPDPSVPTHGPTITLSGHSPADRRMTFTPAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV58</accession>
    <name>A0A0F4JV58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946157.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37729">
        <property type="protein sequence ID" value="KJY37729"/>
        <property type="gene ID" value="VR44_05130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1341"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="287" mass="29680" checksum="3C5DCA4736CDA35B" modified="2015-06-24" version="1">MNQVSIIGLGPMGRAMASAYLDAGYAVTVWNRSPGKDAALLARGARRAGSAAEAVAASRLSIVSLIDVDAVYTALGEADLDGRVLANLSSDVPEKARAAAEWARGRGASYLTGGVNVPPTGIGQEGASIFISGPAEVYEEQRAALDVLAATDYRGADPGHAQLYYQLNMIMFWTAYTGWYQAVAVARANGLTAADILPYAGYTADSMRGFYEGSAPLADADDHDGTHARLAMCAASLEHVLHTAADSGVDTGILAAHAELYRRGVDAGFGADGTARLIGLLGAPETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVJ7</accession>
    <name>A0A0F4JVJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266782.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene292"/>
    <dbReference type="EnsemblBacteria" id="KJY38392">
        <property type="protein sequence ID" value="KJY38392"/>
        <property type="gene ID" value="VR44_03720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8647"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="238" mass="24972" checksum="930441C88A28DA87" modified="2015-06-24" version="1">MDNSSGVGVLDKAALVLSALESGPATLAGLVAATGLARPTAHRLAVALEHHRMVARDMQGRFILGPRLAELAAAAGEDRLLATAGPVLTHLRDVTGESAQLYRRQGDMRICVAAAERLSGLRDTVPVGSTLPMKAGSAAQILMAWEEPERLHRGLQGARFTATALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVASVSVSGPIERLTRHPGRMHAQAVIDAAARLTEALRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVV8</accession>
    <name>A0A0F4JVV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946428.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37106">
        <property type="protein sequence ID" value="KJY37106"/>
        <property type="gene ID" value="VR44_06580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3232"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6843" checksum="629F0633C18E2B8F" modified="2015-06-24" version="1">MSDTTALYTFLNALLGVRVSGGCTQCAATMVCTSKGYGHYFIQTTHQEGCPVYASESSPPYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JW94</accession>
    <name>A0A0F4JW94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_04240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945996.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38114">
        <property type="protein sequence ID" value="KJY38114"/>
        <property type="gene ID" value="VR44_04240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="18376" checksum="A2B5B2C228C2F82C" modified="2015-06-24" version="1">MDNGVSAGSTASTSTLGNIALGLTLLAFGIGHTGVLSGVTAANSVSLAMYVGGAALFLLGLLEYRGGNGFNGTAFAGLGIFWFTWAKGAGASVSDEAAGTFLVLFAMLALTLTLAAASGLFGQGVYGLLTLALVLLAIASFADSAGLAKAGGWVAAVSGLLAWYGATASLAHWPLALGKASGRGAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXU7</accession>
    <name>A0A0F4JXU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protocatechuate 3,4-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000041">
        <property type="protein sequence ID" value="KJY38950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38950">
        <property type="protein sequence ID" value="KJY38950"/>
        <property type="gene ID" value="VR44_02630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6832"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="276" mass="30495" checksum="274C2CFC557F1999" modified="2015-06-24" version="1">MDHAKTEEPYWRPVFEGYEFSRAWEEENLPDVVFLVYNDHASAFDLSLIPTFVLGTGAAFATADEGYGPRPVPGIESDPELAAHIAHSLIRDDFDLTLANEMTVDHGLTVPLSLMFGDVGKWPCKVIPFHVNVVQYPVPSGARCFALGRALRKAIESYDRPLKVQVWGTGGMSHQLQGPRAGLINRAWDNAFLDRLVEDPVGLSRVPHLEYVEEAGSEGIELVMWLIARGAMSDLDGSGDVEVKHRFYHVPASNTAVGHLILENHTRAQEPAEGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXX7</accession>
    <name>A0A0F4JXX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_04805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000089">
        <property type="protein sequence ID" value="KJY37851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946095.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37851">
        <property type="protein sequence ID" value="KJY37851"/>
        <property type="gene ID" value="VR44_04805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1042"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY37851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="449" mass="49689" checksum="F5740573C3BEEA1E" modified="2015-06-24" version="1">MGITGRRDQEILDVVGIGFGPSNMSLAIALKEHGASAPLHPVRSHFFERQPTFGWHRNMLLPSATMQISFLKDLATFRNPVSRFSFVSFLHASNRLVQFVNNQSFIPTRQEFHQYLEWAAAGLSDQVTYGSEVTAIRPVTGPGARTPDLLEIEVRSGDGSARVVTARNVVVSTGLVPRLPEGVTAGERVWHSSEFLTRFNAQDPASLKSVAVVGAGQSAAEVTRFFHDSLPHAQVTAVIPSYGYSVADDTPFANQVFDPDTVDEYYFGTEGARDAFWRYHRNTNYSVVDADVIRALYQRQYDEQVSGVQRLHFRNLTRVDSVEGSDSGARVVLRSLLDDRREELAFDALVFASGYDGLDPARLLGEEFDRHFQRDAAGRHRVERDYRLVATSGLSCGVYLQGGTEHSHGLTSALLSNIAIRSGEIADSIVLRRTERELGRQAEETPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ74</accession>
    <name>A0A0F4JZ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945686.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39008">
        <property type="protein sequence ID" value="KJY39008"/>
        <property type="gene ID" value="VR44_02540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6812"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="69"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="494"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="597" mass="65148" checksum="132F97539FB407CF" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZT0</accession>
    <name>A0A0F4JZT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_01095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945414.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4725"/>
    <dbReference type="EnsemblBacteria" id="KJY39635">
        <property type="protein sequence ID" value="KJY39635"/>
        <property type="gene ID" value="VR44_01095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2932"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="371" mass="39653" checksum="8111C116F2AB3952" modified="2015-06-24" version="1">MTAAGKHHVSRAETTRRVGGRQGRAGIRDVAAAAGVSITTVSDALNGKGRLPDATRRHVREVADRLGYRPSAAARTLRTGKSGLIGLTVTTYGDEPFTFTEFAYFAEMARAATSAALARGYALVILPATSRHDVWSNVALDGTVVIDPSDHDPVVSELVRQGLPVVSDGRPAGTLPVTAWVDNDHEAAVLGLLDHLAAAGARRIGLLTGTTTDTYTRLSTTAYLSWCERVGQDPVYESYPAHDPCAGAVAADRLLARPDRPDAVYGLFDPNGTDLLAAARRYGLRVPEDLLLVCCSESTVYANTEPPITTLSLKPRRIGTAVVQLLIDAIEGVDTGRPVEQVVPTELIIRTSSQRRTRRTTVSPPRSPSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0F5</accession>
    <name>A0A0F4K0F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945761.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38731">
        <property type="protein sequence ID" value="KJY38731"/>
        <property type="gene ID" value="VR44_02950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7322"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="30670" checksum="87117669EEF21A6F" modified="2015-06-24" version="1">MLVLVAPGQGAQTPGFLTPWLELPGAAERVAGWSDAIGLDLVHYGTKADEDEIRDTAVAQPLLVAAGLLSASALNTTAFGAVAGHSVGEITAAAYAGVLGEGDALSFVRTRGLAMAEAAAVTKTGMAAVLGGDQDVVVAHLEKLGLTPANINGAGQIVAAGTAEQIEALIAEKPEGAMKVVALKVAGAFHTHHMAPAVATLAEAAQALTPADPALKYVSNRDGLVVESGADVVARLVGQVANPVRWDLCMETFSELGVTGIVELSPGGTLTGLAKRALKGVPNVALKTPDDLDKAAKLIAELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0U8</accession>
    <name>A0A0F4K0U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_00585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000010">
        <property type="protein sequence ID" value="KJY39739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945327.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39739">
        <property type="protein sequence ID" value="KJY39739"/>
        <property type="gene ID" value="VR44_00585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2823"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="45546" checksum="612D580328A2699A" modified="2015-06-24" version="1">MPQVMEFKLPDLGEGLTEAEIVRWLVAVGDVVTIDQPVVEVETAKAMVEVPCPYGGVVTARFGEEGEELPVGAPLITVAVGAESAPDGAEAEGAANAPRPLIGYGSDHSRPTRRRRVRPVTAAVSAPVAAPAPAAAPVPAAPVAPAAPAGPVPVISPLVRKLARDNGVDLRALRGSGPEGLILRADVEAALRAPEPVAVPVAAPVAVAAQGERIPLKGLRGAVAEKLSRSRREIPEATCWVDADATELMAARAAMNAVDGPKISVLALLARICTAALARYPELNSTVDLAANEIVRLPGVHLGFAAQTERGLMVPVVRDAHTRSPESLSAEFARLTELARAGKLAPSDLTGGTFTLNNYGVFGVDGSTPIINHPEAAMLGVGRIIPKPWVYRGELAVRQVVQLSLTFDHRVCDGGAAGGFLRYVADCVENPAVLLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K123</accession>
    <name>A0A0F4K123_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoate 3-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945711.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38926">
        <property type="protein sequence ID" value="KJY38926"/>
        <property type="gene ID" value="VR44_02655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="44429" checksum="45E26C872D3D6AE1" modified="2015-06-24" version="1">MADAVVDTVAPVPVAVVGAGPAGLMLAHRLGRAGVDTIVIDTRTRHEIATTQRAGILEADAARDLIETGVGDRILREGHEHEGTELRFGGRPHRLDFKELVGASVWLYPQTDVFTDLADARERDGGTVHFGVKDTEVLDITTGAPRVRYTAADGSRHEIRARYVVGADGSRSMCRNLVPEDRRVRYGKEYPFAWFGIMAEAPASAPELVYAHSEHGFALISRRTETVQRMYFQCAPDEPVDAWPDDRVWETLQARVAGEDGFRLKEGPILEKTVLRFRSFVQEPMGWGSMLLAGDAAHTVPPTGARGLNLALHDVKVLADVLLRALGTEGEAALAEYEPRALRRIWRAQNFSHWMTRLLHTPPGASPFDLRRQLGELDNVVGTRAGRAYLAEQYTGWPAASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1E8</accession>
    <name>A0A0F4K1E8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VR44_02415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945673.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39046">
        <property type="protein sequence ID" value="KJY39046"/>
        <property type="gene ID" value="VR44_02415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6773"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="383"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="475"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY39046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="794" mass="85574" checksum="36D686BD0AC0A817" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3S1</accession>
    <name>A0A0F4I3S1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001736">
        <property type="protein sequence ID" value="KJY16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16567">
        <property type="protein sequence ID" value="KJY16567"/>
        <property type="gene ID" value="VR44_40380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="9818" checksum="DC7C953F29838219" modified="2015-06-24" version="1" fragment="single">FFGISPREALAMDPQQRLLLQATWEAFERAGIDPKAMKGSRTGVFAGLMYRDYLTRLSSIPQELEGFRGTASSGSVASGRVSYLFGLEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4Z5</accession>
    <name>A0A0F4I4Z5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6434 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001701">
        <property type="protein sequence ID" value="KJY16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16992">
        <property type="protein sequence ID" value="KJY16992"/>
        <property type="gene ID" value="VR44_40205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6525"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045492">
        <property type="entry name" value="DUF6434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20026">
        <property type="entry name" value="DUF6434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6434" evidence="2">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="136" mass="14568" checksum="2D51E5BFDC588602" modified="2015-06-24" version="1" fragment="single">PARRPKAGRGLCAPVDGTTVIPDGQRCSQVLREFFRREIGPEFHFDGYMRAYIAENAGRTLAEAVAHWHDTRAAAAEPHPIGAQFEFNRFLRAWHAGHPSGTRDEALAAWHAHRSAPRSPAGSAGPAAPAGSAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9P3</accession>
    <name>A0A0F4I9P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001671">
        <property type="protein sequence ID" value="KJY17391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17391">
        <property type="protein sequence ID" value="KJY17391"/>
        <property type="gene ID" value="VR44_39990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="15720" checksum="D2D8A8728A0A44CB" modified="2015-06-24" version="1" fragment="single">MSDETKLVDYLKRVTADLRQTTRRLREVEAEATEPIAIVGMSCRYPGGVRTPEDLWELVSGGLDGISAFPSDRGWDVEALYDEDPDRRGTSYSREGGFLDAAGEFDAGFFGVSPREAQAMDPQHRLLLETSWEAFERAGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IBE5</accession>
    <name>A0A0F4IBE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_39420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001586">
        <property type="protein sequence ID" value="KJY18813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952507.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001586.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18813">
        <property type="protein sequence ID" value="KJY18813"/>
        <property type="gene ID" value="VR44_39420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5972"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY18813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18720" checksum="8DFA4796031805C8" modified="2015-06-24" version="1">MPTHNPSFTVDDDVDVPCPAPGEVWTVGAVILNRDGKAFAHKRSPDRRLFPGTWDIVGGHVEAGETVLEALAREVEEETGWRLTRVRRFLGTTTWTGDDGGGLRHEADYLVEVEGDLDNPTLEWSKHSAYDWFSPDNLACLKENRRPGEFLIHDLIAQAIEDRPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDG4</accession>
    <name>A0A0F4IDG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001542">
        <property type="protein sequence ID" value="KJY19719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952432.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001542.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1294"/>
    <dbReference type="EnsemblBacteria" id="KJY19719">
        <property type="protein sequence ID" value="KJY19719"/>
        <property type="gene ID" value="VR44_39025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5565"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="330" mass="35049" checksum="1BEC3E86CB7468A2" modified="2015-06-24" version="1" fragment="single">GEELALPKRRAGLPSKLVIAPKFVGERALVERCVVTLAGERGLLLTGEPGTAKSMLSELLSAAVCGTSALTVQGTAGTTEDAFRYGWNYALLLAQGPTRQALVDSPVLAAMRAGRVVRVEEITRCLPEVQDALVSILSDRRVSVPELTATEDSVVSAAPGFTVIATANLRDRGVSEMSAALKRRFNFETVGPISDPDAEAALIRRQAVAAVERAGAAFGVDDSVLDALVTVFRDLRSGRSAEGWDVERPGTVMSTAEAVQVAASLGVAAAYLPGGDVLDLLPGHLLGVVRKDDPADHGRLLGYWDGPVRRRAEDGSAMWRRLWDLRGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJ87</accession>
    <name>A0A0F4IJ87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001492">
        <property type="protein sequence ID" value="KJY20716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20716">
        <property type="protein sequence ID" value="KJY20716"/>
        <property type="gene ID" value="VR44_38605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5395"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9162" checksum="0FC1A73B59FCCDBB" modified="2015-06-24" version="1" fragment="single">MVSGAEDAVAELAGKLAAEGRKTKALAVSHAFHSPLMDPILDAFREVAESVAFEAPALPVVSTLTGRTLTAEEAGSADYWVRHVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IK36</accession>
    <name>A0A0F4IK36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-3B C17-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_38050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001433">
        <property type="protein sequence ID" value="KJY22039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952251.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001433.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3753"/>
    <dbReference type="EnsemblBacteria" id="KJY22039">
        <property type="protein sequence ID" value="KJY22039"/>
        <property type="gene ID" value="VR44_38050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="259"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY22039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="35459" checksum="93E4DF212F0538CC" modified="2015-06-24" version="1" fragment="single">MSEQEQNPVKGKLYGVGLGPGDPSLMTLRAVEVIAEADVVAYHSARHGRSIARSIAAKHLRSDHVEEPLVYPVTTETTDHPGGYQGAMEEFYEASAARLAAHLDAGRTVAVLAEGDPLFYGSYMHMHKRLADRYEAEVVPGVTSVSAAAARLGTPLVEGEEVLTILPGTLPEEELTARLAATDSAVVMKLGRTFPAVRGAMEASGRLAEARYVERATMEGERTGLLADTDPDSVPYFAVAVVPSRVGNPGSVPSGPGEVVVVGTGPAGPLWLTPETRRALADAEVLVGYTTYLDRVPVKPGQVRHGSDNKVESERAEFALDLARRGKRVAGVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IL12</accession>
    <name>A0A0F4IL12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001411">
        <property type="protein sequence ID" value="KJY22735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22735">
        <property type="protein sequence ID" value="KJY22735"/>
        <property type="gene ID" value="VR44_37800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5118"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="20402" checksum="9DEC454293DCD75D" modified="2015-06-24" version="1">MLALWVALAPVGPLPFDTGPHAWSLGHRPPAALAVARAVTATGTGGWPYALVVLAGLYAGRTVRQRLTAVAGLALCLALGQAVRRALMELFARPRPPAADWATHAANWSFPSGHATTGALTAGLVIAALTLRGSPGPFRTATVALIALWGAAVGLSRVYLGVHWLSDVLGGWLLATAWVSCAALVYRAYRREPAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4INX0</accession>
    <name>A0A0F4INX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_37460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001379">
        <property type="protein sequence ID" value="KJY23725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23725">
        <property type="protein sequence ID" value="KJY23725"/>
        <property type="gene ID" value="VR44_37460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4911"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY23725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="15904" checksum="FB78E317EC9602E1" modified="2015-06-24" version="1" fragment="single">YVLGKTASAGVLSLPAILVVFLVAAVAKGVRFEAWQWFALTGAIWAGSLVFAALGVAIGYLAGADNVRPLSMLFYFALSILGGLWMPTAAFPQWLQNICEWLPTHAYAGLGQAIELGGAPHAKDVAILAGYFVLFTGAAAWLYRKDSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPB9</accession>
    <name>A0A0F4IPB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001339">
        <property type="protein sequence ID" value="KJY23885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23885">
        <property type="protein sequence ID" value="KJY23885"/>
        <property type="gene ID" value="VR44_36970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4778"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="14546" checksum="140B913E38AD8449" modified="2015-06-24" version="1" fragment="single">SSTDRTPDDAPGTPAPGHGPGPNHSPAPGTPAPGSAPQHAPTPAPSTDPTPDNTPGTPTPGHGPGAPTPGHGTGSGHGPARTSAPAPMAAPGRIPPTADTHAQAPGPALAGAPTTPARGRGGRAGTSSALTPAQLWRRARGLLLALAVLLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPL8</accession>
    <name>A0A0F4IPL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fusA</name>
        <name evidence="5" type="ORF">VR44_36710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001320">
        <property type="protein sequence ID" value="KJY23970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23970">
        <property type="protein sequence ID" value="KJY23970"/>
        <property type="gene ID" value="VR44_36710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4652"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFG_IV" evidence="4">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EFG_C" evidence="3">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY23970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27254" checksum="7D649F7D4BCA6978" modified="2015-06-24" version="1" fragment="single">ARIAEEDPSLVVRTDAETGQTVLSGLGELHLEVAVEKIRRDQGVEVVVGRPQVSYRETVVDGVTGLVFRHVKQDGGAGQFAHVVIDVEPLGEPGFEFRSTVVGGRVPQEYARAVEAGCRDALAEGPLGGHPVTGLRVVLTDGATHSKDSSELAFRAAGRFALREALRASALELLEPVAEVTVTVPEGSVGAVLGDLAARRGRVTGSAARAGTAVVTATVPLAELFGYASRLRGRTQGRGTFTTRPAGLAPVPAGVASNLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPW0</accession>
    <name>A0A0F4IPW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_36490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001306">
        <property type="protein sequence ID" value="KJY24037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24037">
        <property type="protein sequence ID" value="KJY24037"/>
        <property type="gene ID" value="VR44_36490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4600"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046200">
        <property type="entry name" value="DUF6233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19746">
        <property type="entry name" value="DUF6233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="18784" checksum="93EE30BDF1D93200" modified="2015-06-24" version="1">MPASPRGAARPLLTVTAPAPPPAAITLLLPDGQELRVRLYERLQMDTGLWVFRIGVPLWQTTEGGGVEPAEYGTWVTSAQLRPIPGVALDQVPTHRNPAGRAAATATPWVWVLDGRARPTTVHAEGCPLATDRAVPVKTMDALDALGQPGTVACTGCDAAETLLPILAHGQEDAHAPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPW1</accession>
    <name>A0A0F4IPW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_36405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001301">
        <property type="protein sequence ID" value="KJY24065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951945.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001301.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24065">
        <property type="protein sequence ID" value="KJY24065"/>
        <property type="gene ID" value="VR44_36405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="142" mass="15055" checksum="DFEDDF7796F55F0B" modified="2015-06-24" version="1" fragment="single">MGAAEVVGRVPPETTQRAVGYPALFVLVALGALVPVIPTGALVSSAAVVAFHQRTLPLGVLVVIGVAALAAFTGDLALYWLGQRGVRSRGGSRLLESLRRRAAPERLERARVRLEEHRVLVLVLSRPVPAGRIPVMLACLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQ07</accession>
    <name>A0A0F4IQ07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">VR44_36375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01001297">
        <property type="protein sequence ID" value="KJY24082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951937.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001297.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene290"/>
    <dbReference type="EnsemblBacteria" id="KJY24082">
        <property type="protein sequence ID" value="KJY24082"/>
        <property type="gene ID" value="VR44_36375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4527"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="340"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY24082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="491" mass="54310" checksum="F0F24F3B53C78C60" modified="2015-06-24" version="1">MANANVRVRFCPSPTGNPHVGLVRTALFNWAFARHHGGTFVFRIEDTDAARDSEESYVQLLDSLRWLGFTWDEGPEVGGPHAPYRQSERMDIYKDVAQRLQDGGYAYHCYCTTEELDTRRDAARAAGRPSGYDGHCRELSAEQVAAYQAEGRTSIVRFRMPDETITFTDLVRGELSFTPENVPDFGIVRANGAPLYTLVNPVDDALMQITHVLRGEDLLSSTPRQIALYKALMEIGVATGVPQFGHLPYVMGEGNKKLSKRDPESSLNLYRERGFLPEGLLNYLSLLGWSFSKDQDIFSIEEMVAKFDIDGVNANPARFDLKKAEAINADHIRRMDPKAFADACQPWLRAPHANWAPEDFDAAAWERIAPHAQTRVTVLSDITANVDFLFLKEPVEDQASWDKAMKGEPAALLTTARANLLAADWSDPESLKQAVLAAGEAHGLKLGKAQAPVRVAVTGRTVGLPLFESLEILGQERSIARIDAALAKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQF9</accession>
    <name>A0A0F4IQF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Squalene-hopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_35970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001265">
        <property type="protein sequence ID" value="KJY24232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951860.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001265.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24232">
        <property type="protein sequence ID" value="KJY24232"/>
        <property type="gene ID" value="VR44_35970"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="5">
        <location>
            <begin position="48"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="4">
        <location>
            <begin position="343"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="669" mass="73215" checksum="391C43719DE5EAAC" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQU8</accession>
    <name>A0A0F4IQU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001343">
        <property type="protein sequence ID" value="KJY23868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952060.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001343.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5417"/>
    <dbReference type="EnsemblBacteria" id="KJY23868">
        <property type="protein sequence ID" value="KJY23868"/>
        <property type="gene ID" value="VR44_37030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4792"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="86"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="39529" checksum="A2AD9A64E1414D19" modified="2015-06-24" version="1">MSTHGNDTGTEALRPHAEDAFAHELKALEAADDRPRPARWKLSPWAVATYLQGGTLPDGTVITPKYVGPRRIVEVAVTTLATDRALLLLGVPGTAKTWVSEHLAAAVSGDSTLLVQGTAGTPEEAIRYGWNYARLLAEGPSREALVPSPVMRAMAQGMTARVEELTRIPADVQDTLITVLSEKTLPIPELGQEVQAVRGFNLIATANDRDRGVNELSSALRRRFNTVVLPLPATADAEVDIVARRVGQMGRALDLPAVPEGLEEIRRVVTVFRELRDGVTGDGRTKVKSPSGTLSTAEAISVVTGGLALAAHFGDGVLRPSDVAAGILGAVVRDPAADRIVWQEYLEAVVREREGWKDFYRACREVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR91</accession>
    <name>A0A0F4IR91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_36665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001316">
        <property type="protein sequence ID" value="KJY23988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23988">
        <property type="protein sequence ID" value="KJY23988"/>
        <property type="gene ID" value="VR44_36665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4642"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="401" mass="42134" checksum="FACC25B95BCD9B72" modified="2015-06-24" version="1">MEPEDSLVLWNGAPPHVLLIEDDEGDALLVEELVEDSGTEVRLARARSLADALRLLETGTPDCVLLDLHLPDAQGLDGLKKVLARSTETAVVVLTGLSEEQAGLTAVAAGAQDYLVKGRLEADVFMRAIRYAIQRKRTELAAAALQAGRLRAEENARLERGLLPTPLLLDDAADTVTVCARYHPGRAQSLLGGDFYDVVQTPDGATHAVVGDVSGHGPSEAALGVCLRVAWRSFVMAGARGAELLALLERILVAERSGPETFATLVCLTRPAGARAVSVQRAGHPGLLVRSAGGVELRTVPGGPALGILPGWGAGWPLSEVAVGEGDALMLFTDGLIEGRVGPGSDRLDEEGLLEIARKHADLPAEAFVDTLIQTAQGLAADWGGLADDVAVLHLEWNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRA2</accession>
    <name>A0A0F4IRA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001206">
        <property type="protein sequence ID" value="KJY24550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951688.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001206.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24550">
        <property type="protein sequence ID" value="KJY24550"/>
        <property type="gene ID" value="VR44_35040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4082"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="191"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="394"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="575" mass="62128" checksum="F858CB4700DF2189" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISN0</accession>
    <name>A0A0F4ISN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001137">
        <property type="protein sequence ID" value="KJY24997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24997">
        <property type="protein sequence ID" value="KJY24997"/>
        <property type="gene ID" value="VR44_33740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3665"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9443" checksum="7F584E813999D142" modified="2015-06-24" version="1">MTHSGDRPLTITTRGQLTALVLLLAAIAVLAKWHDGPVFWCGALLGLAGIGGYFIRFDSPRGAAQWILAAVGFCMVAMFTIQLLIGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX1</accession>
    <name>A0A0F4ISX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkane 1-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001357">
        <property type="protein sequence ID" value="KJY23806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952093.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001357.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23806">
        <property type="protein sequence ID" value="KJY23806"/>
        <property type="gene ID" value="VR44_37200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4831"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="36237" checksum="65CE9810ED2C37F2" modified="2015-06-24" version="1">MRVGAFVVAAQFPGQGQGEALHRAVRTAEVAEETGLDSVWLAEHHFVPYGVCPSAVTLAALLLGRTRRLRVGTAVSVLPNTHPVALGEQAALLHVTSGGRFTLGVGRGGPWVDLEVFGGGLEAYESGFPEDLDLLRRWLAEPRVGAAGERHGFREVAVVPRPDQALDGDGTGPEVIVACTSPASVRTAARRGLPMLLGMHCGDEDKAGMVALWRETALAAGHAPEAVRSAGHVSAGVCQLADRTADARETLLKAMPGWLRQGLDAHVTVDGRHRAMRDPHAYTELLCDIHPVGTPELAADRLAATSERTGITRFALLSEGSGDLAATEENVRRLGAEVLPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUI1</accession>
    <name>A0A0F4IUI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25133">
        <property type="protein sequence ID" value="KJY25133"/>
        <property type="gene ID" value="VR44_33330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3542"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="147" mass="16061" checksum="4C5A6BA31AB6AF76" modified="2015-06-24" version="1">MCWAVGEQEAGLDYLVDALLRHRVRIGEDTRAEIAVVAEGWGVREAVTRRLVECPGDGLPAELELVEGADTVVGVGDPALDGFLLIPWIRSTGSGRLLVRAHVEEPWGDLSLIPEYYGVLASGQGPVLRLFESFSAREALEELRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUS9</accession>
    <name>A0A0F4IUS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001025">
        <property type="protein sequence ID" value="KJY25780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951062.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25780">
        <property type="protein sequence ID" value="KJY25780"/>
        <property type="gene ID" value="VR44_31645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3037"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20953" checksum="315CFB2210A61E23" modified="2015-06-24" version="1">MEPLTLTTDRLVLRPFAPSDAEEVHAVCQDPEIQRWTQVPSPYERTHAEAWVNEISPASWREDRQYAFAVRLGADGPLVASVGVHVHGPGAYEIGYWAAKEHRGRGYVTEAVTGVARWLFTEVGAGRLEWRAEVGNAGSRAVAEKAGFRVEGTLRAALGVRGTLRDCWVGGLLPSDLGLPSPLPYLPAVSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV26</accession>
    <name>A0A0F4IV26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001069">
        <property type="protein sequence ID" value="KJY25474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951207.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25474">
        <property type="protein sequence ID" value="KJY25474"/>
        <property type="gene ID" value="VR44_32425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3288"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="143" mass="15384" checksum="6202466A7F75E345" modified="2015-06-24" version="1">MNPVNATTPTAVDLFASALHFHPDGEVRAAGRRMGNGDSGSWQLAAFHAETDADVHADHWEMHPEADEAVCCLTGGARIHFRPAGPDDTTDTADAGDTVQLKPGTAVIVPRGRWHRVELDAPSDLMSITLPNGTRHEKRTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVV0</accession>
    <name>A0A0F4IVV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_31675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001027">
        <property type="protein sequence ID" value="KJY25764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951069.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25764">
        <property type="protein sequence ID" value="KJY25764"/>
        <property type="gene ID" value="VR44_31675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3044"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY25764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="433" mass="44120" checksum="15105BD550A73D82" modified="2015-06-24" version="1">MGAAMRRIQAGNALTAFGIGFTVPFLYIYVAQVRGLGSMAATSAFVAFALGALIALPFTGRVIDRRGPVPVVMGAAVAASVGALSLGLSTGLVPILLSALALGAGQAVMQPALATMIVWCSTPSTRTRAFALQFFMQNLGLGIGGLAGGQIVDVSRPGSFTLLFGIEAVMFLVLAGVIATVRMPQAPSIKDALPKDPAQAAGGGWKRMLRHKAMVQLCLLGFVLFFACYGQFESGLAAFGTEAAGISPSTLGFALAANTGAIVVAQFVVLKLVEKRRRSRVIALVGLIWTVAWLIAGFSGLGHGSATMAAAAFVSTYALFGIGEAMLSPTLAPLVADLAPEGSVGQYNSAFALVKQMALALGPLGVPLGAGVPMLYVGIFVLVSLGIAGLALRLGRQLSPVQDNPSLLGGRVVAQGPAVAAKGAEQPAERVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVZ1</accession>
    <name>A0A0F4IVZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001022">
        <property type="protein sequence ID" value="KJY25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951050.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25804">
        <property type="protein sequence ID" value="KJY25804"/>
        <property type="gene ID" value="VR44_31560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2808"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="18031" checksum="7042D99DA43D28A2" modified="2015-06-24" version="1">MDPRPDLRPPSLNADEKTTLLTFLDYLREAVLAKADGVPEPAVRTAGVPSGTSLLQLLKHLTAVELNWFVWAYAGADREQWEDEAAVSADDTAPDLAHAYREAIARANEVALACTDLDRPGARSLRETPPPSMRWVLVHMIEETARHAGHADILREQIDGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW04</accession>
    <name>A0A0F4IW04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001156">
        <property type="protein sequence ID" value="KJY24871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951524.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001156.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24871">
        <property type="protein sequence ID" value="KJY24871"/>
        <property type="gene ID" value="VR44_34140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3754"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="432" mass="44464" checksum="E3CDB1B61BB37E46" modified="2015-06-24" version="1" fragment="single">TGHRFVTPVYAVGKRSAGTLTGDLVLVAQGDLTLGGRTRPDGTVAYTDLDHTYANDFPGATLTPENPLAGIDQLARQVRESGITRVDGEVVVDGRLFAADPVLDPTPTPLIVNDNLIDLLTTPGDRAGAGARLDWRPKVAPYEVTSTVRTVAAGKPTAVTVTADEGGTRIRLSGTIAAGSAPLLRTSPVTDPAAFGRTALIEALGRAGVEVRAAATGANPVGRLPHDYRGDPRVAAYTSPPYEQYAKLILKVSHNLGANLGICLMAVAAGSRQCADGFPVLAGFLGRAGVDRGQVELMDGRGGNPADRATPQALVQMLAYWQRGPDARLFRETLPVLGVDGLLADNCRSCPARGKVFAKTGAAVGGDSLNGRFAVGAITIAGYLDRGGGRFDPFYAGVNGASTANTDPAGILSIGNDLALVAAALQEAPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW14</accession>
    <name>A0A0F4IW14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_34085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001154">
        <property type="protein sequence ID" value="KJY24881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951514.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001154.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000073_gene286"/>
    <dbReference type="EnsemblBacteria" id="KJY24881">
        <property type="protein sequence ID" value="KJY24881"/>
        <property type="gene ID" value="VR44_34085"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20538" checksum="5B09A8A435DFAF2A" modified="2015-06-24" version="1" fragment="single">MDFASSNGGAARSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPEEVREALQIGPDAPIITTDARHRGDAKSALITLVEHALMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWN3</accession>
    <name>A0A0F4IWN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000939">
        <property type="protein sequence ID" value="KJY26445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26445">
        <property type="protein sequence ID" value="KJY26445"/>
        <property type="gene ID" value="VR44_30070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2398"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470332" evidence="2">
        <location>
            <begin position="31"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="553" mass="55399" checksum="F8BA8831AB76DD7E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWR2</accession>
    <name>A0A0F4IWR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000939">
        <property type="protein sequence ID" value="KJY26442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950772.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000939.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26442">
        <property type="protein sequence ID" value="KJY26442"/>
        <property type="gene ID" value="VR44_30055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2395"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="40700" checksum="77A83BF023FEF82F" modified="2015-06-24" version="1">MSLLASWARRHPRAADRIRLLLCVLLLALVTFEGVVLARQPSPPHATVWVSGILVCLSAVPWPGLPLLARAWFAAATTWTVTLLLVLGERPTVVWGAGEAVALLVLLSQVLLHTPARTAAVLGPVLGLGCMAVPVRDTNPGRFTLLFSVLTVVVTAYSLLLRLQSVQRLRELHAVRTAERLELARELHDLVAHHVTGIVVEARAARFTRVTAERAAEVFARIETAGDEALGSMRRLVRILREDDGTPTAPATAPVAGLADIRDLTRRFTGPPVVLYIERGLEDRIPGDVAATAHRIVLEALTNIAKHAATATAVRIGLRTVPAGLEVRVADDGGHPARLSEKARGGGYGLAGMTERAEALGGRLTAGPAPEGGWLVTALLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXK8</accession>
    <name>A0A0F4IXK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_30695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000973">
        <property type="protein sequence ID" value="KJY26188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950887.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000973.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26188">
        <property type="protein sequence ID" value="KJY26188"/>
        <property type="gene ID" value="VR44_30695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2594"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="23262" checksum="631B1B5D980A40DD" modified="2015-06-24" version="1">MTQTQSATISTRLNWLRAGVLGANDGIISTAGLVVGVAGATTSRAEILTAGVAGLLAGSLSMAVGEYVSVSSQRDSERAALELERRELAEDPEAELIELTELLAGRGLTREVAREAAEQLTERDALRAHARVELGIEPDELANPWHAALASLVAFTAGALLPLLAIVLPGASVRVPVTVGAVLGALVLCGVVSARLGGAAVGRAVLRNVLGGGLAMAVTYAVGTWLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXR9</accession>
    <name>A0A0F4IXR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001071">
        <property type="protein sequence ID" value="KJY25456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951213.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25456">
        <property type="protein sequence ID" value="KJY25456"/>
        <property type="gene ID" value="VR44_32450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3294"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="26049" checksum="3E142EB14C36D600" modified="2015-06-24" version="1">MALATRTDRRPSTTRTLWDSTVGKKSVMAVSGLIMLGYLVAHMFGNLKIFFGPDEFNGYAHALRTLGEPFLHYEWALWAVRVVLVAAVVAHAVCAYQLSRRDLRARPVKYAHKRRRASYATRTMRWGGIILALFIVWHLLDLTTLTVNERAWAGHPYENVLATFSTWYGNTIYIVAMAALGLHIRHGFWSAAQTLGAGSARRDRVLKFLANALALVLFAGFVSVPVAVMTGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY98</accession>
    <name>A0A0F4IY98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein AfsQ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_28730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000881">
        <property type="protein sequence ID" value="KJY26972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042816435.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000881.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5498"/>
    <dbReference type="EnsemblBacteria" id="KJY26972">
        <property type="protein sequence ID" value="KJY26972"/>
        <property type="gene ID" value="VR44_28730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2078"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="25749" checksum="14216591A7057818" modified="2015-06-24" version="1">MGQNEPVPFLLLIEDDDAIRTALELSLTRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGEREASDSAVFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEEVPSSPTLIRTVRGVGYRLDSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYH0</accession>
    <name>A0A0F4IYH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000909">
        <property type="protein sequence ID" value="KJY26714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950651.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000909.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26714">
        <property type="protein sequence ID" value="KJY26714"/>
        <property type="gene ID" value="VR44_29400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2244"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="24100" checksum="A87D8721AE4EC3F8" modified="2015-06-24" version="1">MRLSELSERSGVSTATIKYYLREGLLAPGRRISATTADYDEAHLRRLRLVRTLLQVGGLSVAAAGEVLRHVDDDSLGRTFRLGAALWALPHPPAPDAEEGDEAQVTARREVDLMLEELGWESARELAPVNPDHTSLVEAVASLIRLGYPWNAEMMTPYARMMHQVAVHDLDFVETYPSESERVEAAVAATILFEPILRAMHRIAQQEETVRRYGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYM6</accession>
    <name>A0A0F4IYM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000870">
        <property type="protein sequence ID" value="KJY27102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27102">
        <property type="protein sequence ID" value="KJY27102"/>
        <property type="gene ID" value="VR44_28455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2016"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="64" mass="7372" checksum="93C5C18A31A6A54E" modified="2015-06-24" version="1" fragment="single">GREVLLPAGTITRIDTAEEKIYVDRTKEQIKDAPDFVKEKHLGDASYHQEVGGYWGDTVRRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0V4</accession>
    <name>A0A0F4J0V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000928">
        <property type="protein sequence ID" value="KJY26536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950728.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000928.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene795"/>
    <dbReference type="EnsemblBacteria" id="KJY26536">
        <property type="protein sequence ID" value="KJY26536"/>
        <property type="gene ID" value="VR44_29815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2343"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="499" mass="52134" checksum="099B0CEC43722A18" modified="2015-06-24" version="1">MKTVNHWIGGKTVEGASGNYGPVTDPATGEVTTQVALASAAEVDAAVQVAKEAFLSWGQSSLAARTKVLFAYRALLDANRDAIAELITAEHGKVHSDALGEVARGLEIVELACGITTQLKGELSTSVSNRVDVAAIRQPLGVVAGITPFNFPAMVPMWMFPLAVACGNTFVLKPSEKDPSAANKLAELATEAGLPAGVLNVVHGDKVAVDALLSHPDVAAVSFVGSTPIARHIHTTASANGKRVQALGGAKNHMLVLPDADLDAAADAAVSAAYGSAGERCMAISAVVAVGAIGDVLVEKIRERAEKIKIGPGNDPASEMGPLITAAHRDKVASYVKGAADQGAEVVLDGTGYTVEGHENGHWIGLSLLDHVKTDSDAYRDEIFGPVLCVLRAETYEEGVALINASPFGNGTAIFTRDGGAARRFQLEIQAGMVGVNVPIPVPVGYHSFGGWKDSLFGDHHIYGNDGIHFYTRGKVVTTRWPDPSEDHAGVDLGFPRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J153</accession>
    <name>A0A0F4J153_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27463">
        <property type="protein sequence ID" value="KJY27463"/>
        <property type="gene ID" value="VR44_27465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1661"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="25709" checksum="0C5B4D61F8E7084A" modified="2015-06-24" version="1">MVPLRPLGTSDILGGALTALRRYGGTLCGALLLGQLMAGLLVTAAAGAATLASLSPRSGSRVFVWTLFPAAGLFLLFTCALATALIAALLRPAVLGRPVTVPGLLLSALPRTPAVLGTQLLALLVAAGPFAVLVALGVPPLAALPLLPVALWLGVLSSLAPTAAGYEGLGPVAALRRSAQLVRGAWWRALAVTAPAVVFTAAAGYALLLWFGLPGALSALVLLPAFPQLPAGLLYVDRRIRREHLAEAFAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J251</accession>
    <name>A0A0F4J251_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_26660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950153.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000793.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27828">
        <property type="protein sequence ID" value="KJY27828"/>
        <property type="gene ID" value="VR44_26660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1491"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="82"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="44071" checksum="717B137639095570" modified="2015-06-24" version="1">MTVESTAARKPRRSSGTKRAAGAASARKTAAATAQPHDAEPQLVQLLTPEGERVEVGNHPEVAEFAAFVADVTTEDLRGLYRDMVLTRRFDGEATALQRQGELGLWASLLGQEAAQIGSGRALRDDDYVFPTYREHGVAWCRGVDPTNLLGMFRGVNHGGWDPNGNNFHLYTIVIGSQTLHATGYAMGVAKDGADSAVIAYFGDGASSQGDVMEAFNFSAVYNSPVVFFCQNNQWAISEPTERQMRVPLYQRAQGFGFPGIRVDGNDVLACLAVTRWALDRARRGEGPALIEAFTYRMGAHTTSDDPTKYRADEETAAWEAKDPILRLKAHLLASGGADEAFFEELEAESEALGKRVREVVRAMPDPDTMAIFENVYADGHALVDEERAQFAAYLASFEAEEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2B8</accession>
    <name>A0A0F4J2B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Streptothricin acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000786">
        <property type="protein sequence ID" value="KJY27898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950120.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000786.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27898">
        <property type="protein sequence ID" value="KJY27898"/>
        <property type="gene ID" value="VR44_26490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1483"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008125">
        <property type="entry name" value="Streptothricin_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01754">
        <property type="entry name" value="SACTRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="191" mass="20556" checksum="CE3B3776D230632A" modified="2015-06-24" version="1">MTTPGAPPVQYRTARPGDREAIEALDGSFHTRTVFEVESSATGFALREVPVDPPLHKVFPPDEPEEPEAADEPEEDGTGHARTFVALDGGTLCGFAAVRYAPWNRRLTVEDIEVAPAHRGRGIGRALMDLAAGFARERGAAHLWLEVSSVNAPAVHAYRRMGFTLCGLDTALYDGTPAAGERALFMSRPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J478</accession>
    <name>A0A0F4J478_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_26865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000801">
        <property type="protein sequence ID" value="KJY27741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950192.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000801.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3158"/>
    <dbReference type="EnsemblBacteria" id="KJY27741">
        <property type="protein sequence ID" value="KJY27741"/>
        <property type="gene ID" value="VR44_26865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1532"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="384" mass="40528" checksum="70A286B5A4B1FE1B" modified="2015-06-24" version="1">MNLELSEEQEAVRRLARAFTEREVSPYAADWDRAESVDRAIVKKLGDVGFLGLTVPEEYGGSGGDHLSYALVTEELGRGDSAVRGIVSVSLGLVAKTVAAWGTEEQKRSWLPRLCSGEALGCFGLTEPGTGSDAAALTTRAVREGDAYVITGSKMFITNGTWADVVLLFARTDPATPGHRGISAFLVPADAPALTRREVHGKLGLRGQATAELALDGVRVPASAMLGPEGKGFSVAMSALAKGRMSVAAGCVGIAQAALDAAVSYAGQREQFGKPIAHHQLVQELIADISVDVDAARLLTWRVADLIDRGRPFATEASTAKLFASEAAVRAASNALQVHGGYGYIDEYPAGKLLRDARVMTLYEGTSQIQKLLIGRARTGVSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4J7</accession>
    <name>A0A0F4J4J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27861">
        <property type="protein sequence ID" value="KJY27861"/>
        <property type="gene ID" value="VR44_26575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1440"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="12495" checksum="24D36BE696DDBEF9" modified="2015-06-24" version="1">MSVGPDPTHRPTALATTAGPGPTVTATAAPPEAAALAERYRAAGGDPAVYGIQREAGPDGVPRLVVRTRDANGDDTVFRKQHASIASYLRAQEGVPLAGGYLIDVFGPDGRLLHRLDTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4L5</accession>
    <name>A0A0F4J4L5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000666">
        <property type="protein sequence ID" value="KJY29180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29180">
        <property type="protein sequence ID" value="KJY29180"/>
        <property type="gene ID" value="VR44_23580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.661"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="313"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="42320" checksum="8E1F51501C338418" modified="2015-06-24" version="1">MRSARAARYCATVAARGLALIVLVPVLVYSAVLCLVGVGLLVMPFELRLLRRLADAERTRLGTWAATPATPAGPHARSTLTAMLSEPATSRDLRWAPWMAVAGTLLGSIGAALFVFPAAVLVLICLWWLFPADDPVRPLLDVPVDSWASAAYAGAPQLLLSLLLALVGPPLMARPAAASSRRLLAPSAAAVLAERVAALDRTRTGALRAHGDELRRIERDLHDGTQARLVSLAMQLGLAERALGSNPAGVGPLLTRAREGAEEAMAELRDLLRSVYPPVLADRGLADALSAVVARCPVPATAHLADLGPLPAQVEVAVYFAITEALTNAAKHSHARSASITLARVDDTLRAEITDDGRGGAAEGHGTGLRGMRRRIEAVDGTLRVQSPPGGPTVITLECPCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6E2</accession>
    <name>A0A0F4J6E2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000617">
        <property type="protein sequence ID" value="KJY29775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949309.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000617.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29775">
        <property type="protein sequence ID" value="KJY29775"/>
        <property type="gene ID" value="VR44_22100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.301"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="196"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="353" mass="37032" checksum="92EB38842219EA22" modified="2015-06-24" version="1">MTPHAVDRSVSLTAEALRKVAHLDWSVPAAGLEWSCYGTAVHIAGDFTAYAAQLTGRATAAWVPFEISADPGTTPEGLIEIIEATGGLLSAAVAAARPGDRAWHPYGTAGADGFAAMGVVETLLHTHDILGALGTHDWEPDPDLCEQVLDRLFPQAPRTAAPWPVLLWVTGRAALGDLPRRPVWRWYADPVDAGRVLLCEIFPQAAADLHAGGTGGFAWAGDGPFEGTRAASGMVVKAKEQGTYRPGWGPYAIVRKDDGRAIGGIGFHGAPDADGNAEIGYDLVPSARGYGYATDAVRGLAAWAFRQPGLTALHASVDADNAPSHGVVGRAGFERTGTTDDDGVRYVLRAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J709</accession>
    <name>A0A0F4J709_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000585">
        <property type="protein sequence ID" value="KJY30162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949112.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000585.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30162">
        <property type="protein sequence ID" value="KJY30162"/>
        <property type="gene ID" value="VR44_21080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8895"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="66" mass="6906" checksum="F362A89746E984ED" modified="2015-06-24" version="1">MSTTPSLPRRKPGASGRTFEMQEPDPAAPGRALRARAAEGWERFVRRADIGARQEAGGAGGGDTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J745</accession>
    <name>A0A0F4J745_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949103.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30207">
        <property type="protein sequence ID" value="KJY30207"/>
        <property type="gene ID" value="VR44_21020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8935"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24639" checksum="1378F894D51618B2" modified="2015-06-24" version="1">MTTSTDQRPRAALFDLDGTLVDTNYLHSLTWWQALHQNGHDVPMARIHRAIGMGGDRILEHLLGSAHDPSQDQRLRDAHHALYATWFDSLPVLDRAADLLRAIAERGLRIVLASSASADEVEAIRAALGADDVISGATSADDVDRSKPAPDLVHQALALTDAAPGEAVFVGDTVWDVEAAARAGVPCIGLLTGGISEAELTAAGPVTVYRGPPELLRSLDSSPLAGKAPRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7M0</accession>
    <name>A0A0F4J7M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyguanosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_22040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949297.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000615.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000037_gene7459"/>
    <dbReference type="EnsemblBacteria" id="KJY29789">
        <property type="protein sequence ID" value="KJY29789"/>
        <property type="gene ID" value="VR44_22040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.288"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="25332" checksum="145C4C5F035DCC52" modified="2015-06-24" version="1">MPVICVGGMIGIGKTTVAELIAKELGSEVFYESVEDNPILPLFYTASPEEIQAKRYPFLLQLYFLQTRFAAIKEAYKQGDNVLDRSIYEDWYFAKVNHDLGRISSLEMQVYEGLLDEMMREIEGLPYRKAPDLMVYLKADFETVLHRIGLRGRDFEQDESLVEYYRTLWSGYDDWVHKHYSASRVLVIDMNHTDVVNNPEDAARVAQEVKDALATGEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7W3</accession>
    <name>A0A0F4J7W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29889">
        <property type="protein sequence ID" value="KJY29889"/>
        <property type="gene ID" value="VR44_21715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.223"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="66"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="41872" checksum="32549F18BE8A9DAA" modified="2015-06-24" version="1">MPGEGGVGGVTDPADEAARRTERLVTAWRGASRRLTRGPREATVGELLAGLADAPYDMDAPGDIYGDGVVADLERRVADLLGTEDAAFFPTGTMAQQIALRCWAGRTGNPVVAMHPLGHPERWEGGAVSAVSGLRTVHPVQEPRQPTPEEVREHPEPFGTLMLELPLRDAGFLLPSWEELTGLVDAARERDAVVHFDGARLWETTVHFGRPLAEIAGLADSVYVSFYKSLGGLSGACLAGTRGFVEETRVWRHRYGGQVFRQFPQALSALAGLERELPLLPAYVEQARRVAGALREGFEAAGVPWFRINPGVPHTHQFQVWLPHEADRLTEAGARLAEEEGTVLFGRWSAEGLAPGLSMTEVTVTQPGLAWTPEDVRSAVAGFLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8D2</accession>
    <name>A0A0F4J8D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_23500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000663">
        <property type="protein sequence ID" value="KJY29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949564.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000663.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29216">
        <property type="protein sequence ID" value="KJY29216"/>
        <property type="gene ID" value="VR44_23500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.642"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="60"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="169"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="562" mass="60738" checksum="A571521ED8377EC2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8G5</accession>
    <name>A0A0F4J8G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted/membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042818470.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3105"/>
    <dbReference type="EnsemblBacteria" id="KJY30687">
        <property type="protein sequence ID" value="KJY30687"/>
        <property type="gene ID" value="VR44_19865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8592"/>
    <dbReference type="eggNOG" id="ENOG50331I5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16577" checksum="D12568F6CD93E6FF" modified="2015-06-24" version="1">MKMLLALLVSGLVVALVVIGLFVFGLRRRLIQRSGGTFDCSLRWGVAEEPDVSGKGWVYGVARYSGDRIEWFRVFSYSPRPRRLLERSSIEVLARRAPEGEEELALLSDSVVLGCSHQGTRLELAMSEDALTGFLAWLEAAPPGQRVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J931</accession>
    <name>A0A0F4J931_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000573">
        <property type="protein sequence ID" value="KJY30314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30314">
        <property type="protein sequence ID" value="KJY30314"/>
        <property type="gene ID" value="VR44_20775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="175" mass="17920" checksum="5BC3A771F1951094" modified="2015-06-24" version="1" fragment="single">MAATGNADTNVGHGVLIEAVGRALSTHGRAVLTGPAGAGKTEVAHAVAAAAEARRETVLRLAPDAADQHIPEASAAALLGPQRTAIALLRREADAPRAGRDHVALRLALAEVLRTLAASGPVLLLLDNAQWLDADSTDLLRFALRLTPPRVRVLVAERARGGAPVAETLCGPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J996</accession>
    <name>A0A0F4J996_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_20765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000572">
        <property type="protein sequence ID" value="KJY30333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949053.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000572.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30333">
        <property type="protein sequence ID" value="KJY30333"/>
        <property type="gene ID" value="VR44_20765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470505" evidence="7">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="166"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY30333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="490" mass="49253" checksum="6B7A8A9903BE1A98" modified="2015-06-24" version="1" fragment="single">MVAAALGAALTFGAPAALAGTAPVGPSGSAVAVAPKAPKASAPASSQSATWVAGTRAYLVITAAGDTSAVRSAVTANGGTVFSYFDQIGVVVAHSASASFAATMRGVSGVQQVGATRTSDVPADAYNPALPANPAQASTPTGEPARADMTQIKADQAWAVNPGSASVKVGILDTGVDDQHQDLAPNFNAADSVSCAYGKPDTRAGAWRDVDTHGTHVAGTIAAAKNGKGVVGVAPGVKISAVRVAEPGNSFFFAENTICGFVWAGDHGFKVTNNSYYTDPWQFNCPDNIDQAAIIEGVKRAQEYAEGKGSLQIAAAGNENYDLAHKSTDTASPNDSTPVTRTITNACLDIPTELPGVVTVAANGTGTTKASFSNFGQGVIDVAAPGQDVYSTLPGGKYGTKSGTSMATPHVVGVAALIASANPGITPAQIRDKLAAQANDIACPADGRCTGTTANNSFFGEGQVDALKAVGATPPAGKYFENTADFAIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9A9</accession>
    <name>A0A0F4J9A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000566">
        <property type="protein sequence ID" value="KJY30404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949015.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1084"/>
    <dbReference type="EnsemblBacteria" id="KJY30404">
        <property type="protein sequence ID" value="KJY30404"/>
        <property type="gene ID" value="VR44_20535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8818"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="26814" checksum="583C63DF41F2CDE5" modified="2015-06-24" version="1" fragment="single">DVYKRQLLVRTGREMRLTQAGEALVRHAAGILAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPTALAAMRAEHPGTRISLVEAEPPRSVEMLREGDCDLALAFRYGGAAAVAEWEDLVVTPLLTDRLVGLVPEGHPLAGAGRVGMAELADEPWIAGCPRCRRHLVEVCEGAGFTPRIDFATDDYPAVVGLVGAGLGVAVLPELAVESVRAKGVSTLAVEPAVEREVVALTLPDLARVPAVAATLGELVRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAB7</accession>
    <name>A0A0F4JAB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="7" type="ORF">VR44_18810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948697.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000515.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4122"/>
    <dbReference type="EnsemblBacteria" id="KJY31130">
        <property type="protein sequence ID" value="KJY31130"/>
        <property type="gene ID" value="VR44_18810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8373"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="181" mass="18814" checksum="1DD014D74555B707" modified="2015-06-24" version="1">MSQNNPGPRHDVDVLIRRVDPEVPIPAYGHPGDAGCDLVTTVAAELEPGERAVLPTGVSIALPDGYAAFVHPRSGLAARCGLALVNAPGTVDAGYRGEIKVIVVNLDPRESVRFERFDRIAQLVVQRVEKVRFHEVAELPGSARADGGFGSTGGHAAVAGSGAGQQGGNGYASVVTDREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBI1</accession>
    <name>A0A0F4JBI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclodipeptide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_17905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000484">
        <property type="protein sequence ID" value="KJY31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31545">
        <property type="protein sequence ID" value="KJY31545"/>
        <property type="gene ID" value="VR44_17905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8125"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030903">
        <property type="entry name" value="CDPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038622">
        <property type="entry name" value="CDPS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16715">
        <property type="entry name" value="CDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04539">
        <property type="entry name" value="tRNA_cyclodipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25638" checksum="12CACDBE9CE3C0CE" modified="2015-06-24" version="1">MTTATRTSAFRVDPYTPHCQVIAGEGDHAVIGISPGNSYFSAQRVHALAEWALDNFRQADLIYTDLHVAEMYVAMGYPEDEARRKTVKNLRGVRAKVTNAVADIDPSGTRLRGRPMSSLQGIPAYDRMHADLLERLGTDPAFAQTANELVDIFLSSKVLGGQQATAHQRKVCLDYVCAEAPLFLDTPAILGVPSSLNCYHQALPMADLLYSRGAGLRASRNQGHAVVTPATEGDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBQ8</accession>
    <name>A0A0F4JBQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948644.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000507.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31239">
        <property type="protein sequence ID" value="KJY31239"/>
        <property type="gene ID" value="VR44_18530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8301"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="461"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="691" mass="68777" checksum="F5B0E6549446119E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBW5</accession>
    <name>A0A0F4JBW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000507">
        <property type="protein sequence ID" value="KJY31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31238">
        <property type="protein sequence ID" value="KJY31238"/>
        <property type="gene ID" value="VR44_18525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8300"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34770" checksum="F7DBE9BE741F3414" modified="2015-06-24" version="1">MVQRIDVTAADGVRLAAWEFRDPPAEPRQPAVLLLHGLMGRAFHWAGTASWLGEHRRVVALDQRGHGQSEHPATNGPGGPGGPAGPGVLRGLSGPTGFGAPPPGAGAPPPSLGREAFVADAEAAIEQLGLGPVVLIGHSMGALTGWQLAARRPDLVQALVICDMRASALGEASQQEWEEWFRRWPLPFPTQDAARRWFGEDDPRVERPDPGRGAFFAEVMHQAPDGWRPLFSRRQMLTARETWVHDAHWEELAQVRCPTLVVRGLDGELGRAEAQEMVRVLPAGQYAEIPDAGHYVHYDQPAALRAALEPFLEGVAGMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC49</accession>
    <name>A0A0F4JC49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000558">
        <property type="protein sequence ID" value="KJY30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948956.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000558.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30541">
        <property type="protein sequence ID" value="KJY30541"/>
        <property type="gene ID" value="VR44_20210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8748"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="213"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="874" mass="91676" checksum="92AF187883074CE4" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD32</accession>
    <name>A0A0F4JD32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000423">
        <property type="protein sequence ID" value="KJY32262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948217.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000423.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32262">
        <property type="protein sequence ID" value="KJY32262"/>
        <property type="gene ID" value="VR44_16270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7707"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021957">
        <property type="entry name" value="DUF3574"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12098">
        <property type="entry name" value="DUF3574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470387" evidence="1">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="162" mass="17505" checksum="5D7E825A822E57DC" modified="2015-06-24" version="1">MRSPRISTPAAGLLAAAALLFAFGGPVSQAAFGTPTASAAAAPAAQPAAEQLGSPYVSTHLYFGTGRHNGNPPITEAEFNKFLAEVITPRFPSGLTLQEGRGQWRDKEGDINSERSYELTVMYPVREAAARNADIEYIRKLYCKTWELESVGRADVRAQVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE39</accession>
    <name>A0A0F4JE39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000403">
        <property type="protein sequence ID" value="KJY32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948094.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000403.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32617">
        <property type="protein sequence ID" value="KJY32617"/>
        <property type="gene ID" value="VR44_15615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7524"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470874" evidence="1">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17202" checksum="D483CB714F18701F" modified="2015-06-24" version="1">MTAPLFPGRARRSVAALGAVSAGLLLLSACDKPTPLATVTVGSSSVSAESECRADGQELSMDKVQECLTGRKDAKTIEYGRGDTLRLGVEPKIVEDGKKWQAVLDGQPITEPSANTYRSFAGADVFATGGQGEAPQSKMLSFVQVGEDGKPLAVWSFKLKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEL1</accession>
    <name>A0A0F4JEL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000402">
        <property type="protein sequence ID" value="KJY32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32630">
        <property type="protein sequence ID" value="KJY32630"/>
        <property type="gene ID" value="VR44_15610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="454" mass="46281" checksum="FA9907D6149872CC" modified="2015-06-24" version="1" fragment="single">MAPVRSSPDGSGPARRAGRAVGRALHLPFTGTARGIRRVTHAHGAGESGLGRLIELHAINGAGDVMITVALASTVFFSVPTDEARGRVALYLAITMAPFTLLAPVIGPLLDRLPHGRRAAMACAMLTRAVLAVTMSGAVATGGLELYPAALGVLVASKAYGVVRSAVVPRLLPAGFSLVKANSRVTLAGLLATGLAAPVGAALHTIGPAWPLYGACAIFVWGTFAAFQLPHKVDEAKGERRARLSTHEPHSKRPGLRTVSRPVLCGLLANAAMRVLSGFLIFFLAFLLREQPLGGQSAAVSLGIVGASAGIGNACGTAVGAWLRARAPEAIVASVLSATLVVTILAALVFSGPFMAVLAGTAGFCQALAKLSLDAMIQRDVPEAVRTSAFARSETLLQMAWVLGGGIGIALPLNGVLGMAVASVVVALGTAVALRGLLTTRHPRGSTKSSPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JER8</accession>
    <name>A0A0F4JER8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948065.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3285"/>
    <dbReference type="EnsemblBacteria" id="KJY32695">
        <property type="protein sequence ID" value="KJY32695"/>
        <property type="gene ID" value="VR44_15415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7484"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22584" checksum="B7FF2F992A7B0623" modified="2015-06-24" version="1">MFRTRVEGLENIPGTGPVILAGNHLTFIDSMILPMVCDRTVHFIGKDEYVTGKGLKGRLMAWFFTGSGMIPVDRDGANGGVAALMTGRRILEEGKIFGIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVIPFAVIGTDKLQPGGKGMPRPGRVTIRFGEPMEFSRYEGMDRDRYVLRAVTDSVMAEVMRLSGQEYVDMYATKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGS4</accession>
    <name>A0A0F4JGS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947751.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000352.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33547">
        <property type="protein sequence ID" value="KJY33547"/>
        <property type="gene ID" value="VR44_13700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7016"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="236" mass="25288" checksum="E28544BD534CF053" modified="2015-06-24" version="1" fragment="single">FLPAARQVLAAERAAAALAAELAVPGARAFGLGTITGLGERLDRILDAYQQHAPEVRVELHSAPVQERLARLADGRLDAAFVRGEVPAGTHDVRFLPLPPDELMVALPARHPLAERSELDLADLAELPLRLTERRNHPALVDLVLTACHGAGFQPVPGPASSTLQDTLAAIGTGTPMWTVVYAANARLTSHPRIAFRPLRNRVLALPLALGMRRTVPHPELLVAACRGRAAHDHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHB1</accession>
    <name>A0A0F4JHB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000342">
        <property type="protein sequence ID" value="KJY33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947700.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000342.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33737">
        <property type="protein sequence ID" value="KJY33737"/>
        <property type="gene ID" value="VR44_13425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6921"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18384" checksum="69AE83DD3508780F" modified="2015-06-24" version="1">MTALKKDIAKDAVDAITDQWYAVRPDLDTTPMAVFGRIYRISKAMGDAVERAYNRHGVSRGEFDVIATLRRSGTPYTLSPRELSATLMLTTGGMTGRLDKLEKAGLLTRSPDPHDRRGLQVTLTDRGLALVDEAVTAGIEVNRAGLADFSPEEVEELGGLLRKLLAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHD1</accession>
    <name>A0A0F4JHD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33757">
        <property type="protein sequence ID" value="KJY33757"/>
        <property type="gene ID" value="VR44_13405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6917"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7546" checksum="2D0017134E8B8D49" modified="2015-06-24" version="1">MKPPTAPPAAARSRAPLAHLPVQAGPSDVPPGAASPLSGCADAPLTSETPLPGSAYAPLTSETPLVHEAPLTSEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHV8</accession>
    <name>A0A0F4JHV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000360">
        <property type="protein sequence ID" value="KJY33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947813.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000360.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33404">
        <property type="protein sequence ID" value="KJY33404"/>
        <property type="gene ID" value="VR44_14050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7113"/>
    <dbReference type="eggNOG" id="ENOG5033YKU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13800" checksum="1B556959BF95C580" modified="2015-06-24" version="1">MDHATPLEQALHVARALVLADLAAGEVADADVVSLVEDSVTHRRWWVEQWPEGVDYLAGLVAQDVKDALLEKYGRWPLCPVCEHGEPHALDVEPELGRDPHWVCSEAGVKVAAVGGLGPVFHPGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIR7</accession>
    <name>A0A0F4JIR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34242">
        <property type="protein sequence ID" value="KJY34242"/>
        <property type="gene ID" value="VR44_12325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12296" checksum="3C058ED36EFDC71E" modified="2015-06-24" version="1">MTISPSGRWAQPPTIRPSHHTVGPTLPYRSNSSGTWAGSRYQSRCRQPIGVGSSAGSRAAPGRGAAGASTCSGRAWPGPQASSTSTACVRARALRVSVRVQPVHHRRSSVVTGPKAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIV6</accession>
    <name>A0A0F4JIV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947968.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32896">
        <property type="protein sequence ID" value="KJY32896"/>
        <property type="gene ID" value="VR44_14940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7404"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20067" checksum="29B14EE8BF13E49F" modified="2015-06-24" version="1">MTTPLRKDAARNWQRIVSVARDLVDEGTPLQLNDVARRAGLGVGTVYRHFATPEALLETVAAPCLEALAAHGRQALTDADPWRGLTGFLFHTVEAQVTDAALPPVAAAATDAVPRTTELKSSLASAGATLLARARDAGVVRPDLTAADLVPLMCGVAHAVSVHGGTPADRVDTAHRYLTALLEGLRTTPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJA0</accession>
    <name>A0A0F4JJA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947624.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33889">
        <property type="protein sequence ID" value="KJY33889"/>
        <property type="gene ID" value="VR44_13015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6721"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="604" mass="65354" checksum="45C77266FA9B21EC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKB4</accession>
    <name>A0A0F4JKB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000262">
        <property type="protein sequence ID" value="KJY34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947306.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000262.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34777">
        <property type="protein sequence ID" value="KJY34777"/>
        <property type="gene ID" value="VR44_11325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6160"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470603" evidence="3">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="419" mass="46071" checksum="989C8F14AD62EC32" modified="2015-06-24" version="1">MTSSRKTLGTSTTPHPAASASVSAVRPRRPGPPALPFIGHAWPLMRSPLRFVSELASYGDVVPVRLGPLPVEAITHPDLVHQVLVTQARHFVRGRLFEKAGRIGGEQGLVVTSGTTHLKDRRALQPHFRREHITGFAEGIRQATEEATAHWKPGQIVHVDRMATEIALASLVRSLLGDRPSKELTGVFHQHLPTLSKGLMTRAVLPEWCARLPLPAHRAFQRAIDTTRAAVEEAITASRRPGADQTGLLDILTAQRDDDGRPLDGAPATPANITALTYTGRVITETLRRYAMWLAMRRTTGPVTLGEHTLPVGTEVVYSAYALHHDPRWFPHPYRFDPDRWLPETAHALPKGAYIPFGSGVHKCIGDSLALMEITIALATICRHWHVTPLPGRPVREVARADVHPDHLPMIATPRTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKS2</accession>
    <name>A0A0F4JKS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000252">
        <property type="protein sequence ID" value="KJY34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34917">
        <property type="protein sequence ID" value="KJY34917"/>
        <property type="gene ID" value="VR44_11140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6112"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13295" checksum="958CCC8337DB1374" modified="2015-06-24" version="1" fragment="single">PTPHRAGYTQVELTAPDAGYEFDLKAGKVVPAETATWFLARDAQSFVPSEESDSFVSDGEALTVPGCLHGIETKPVTSLPFSALAGERPFCVRSPDRRDLAVVRLRRAAAAGPVTIVVDQYHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKV6</accession>
    <name>A0A0F4JKV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_11095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000250">
        <property type="protein sequence ID" value="KJY34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947266.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34957">
        <property type="protein sequence ID" value="KJY34957"/>
        <property type="gene ID" value="VR44_11095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6103"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="245"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="573" mass="63839" checksum="F9EB18E768E8004E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKX4</accession>
    <name>A0A0F4JKX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000287">
        <property type="protein sequence ID" value="KJY34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000287.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34459">
        <property type="protein sequence ID" value="KJY34459"/>
        <property type="gene ID" value="VR44_11860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6377"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="121" mass="13636" checksum="931698AC650B92C7" modified="2015-06-24" version="1">MTENVWNYDETTARQQGIDLRGFKVEAVDGAIGKVDKHSDEAGSAWIVVDTGVWIFGKEVLLPAGTIARIDVDEERIHVNRTKEQIKNAPEFHREKHLDNPDYHDELAAYYLPGTPFGGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLK3</accession>
    <name>A0A0F4JLK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000274">
        <property type="protein sequence ID" value="KJY34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947351.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000274.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34643">
        <property type="protein sequence ID" value="KJY34643"/>
        <property type="gene ID" value="VR44_11560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="85"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34345" checksum="3F90C3094372A9EE" modified="2015-06-24" version="1">MTTARPSLDPELHELLAGMPLMSQLSPEVLAQVRPFSSMPVAPLLEGRAVNRREVTAASSDGTPIPLSVFSPANTDRATAAPCVYWMHGGGMVMGDRFSQIDIPLEWLDEFGAVVVSVDYRLAPESTGIVPVDDCYRGLLWIAEHSEELGIDPARIIVAGASAGGGLAAGVTLLARDLGTPPIAAQVLIGPMLDHRNATASSLQYSNGPGVWTREMNGFGWHCLLGDLTDDEVPAYVSPSLADDLAGLPTTYIDTGSAEVFRDEDTDYATRIWAAGGQAELHVWAGGFHGFDALYPQAHISATARRTRTDWLARLLPTNPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JME8</accession>
    <name>A0A0F4JME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_11010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947246.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34989">
        <property type="protein sequence ID" value="KJY34989"/>
        <property type="gene ID" value="VR44_11010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6086"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="755" mass="77800" checksum="A810EAC86EFB3EDA" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN84</accession>
    <name>A0A0F4JN84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000209">
        <property type="protein sequence ID" value="KJY35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946975.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000209.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35650">
        <property type="protein sequence ID" value="KJY35650"/>
        <property type="gene ID" value="VR44_09540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5309"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="59" mass="6530" checksum="3BD7DD75912C5A19" modified="2015-06-24" version="1">MNAVRTAGRRVPARQPLRGPRRGVRPRPAPPLTALLRRRAAWGLALTRARALTAPKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNU8</accession>
    <name>A0A0F4JNU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_10080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947078.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35504">
        <property type="protein sequence ID" value="KJY35504"/>
        <property type="gene ID" value="VR44_10080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5615"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470902" description="Peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="93"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="239"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="34651" checksum="BA45ACEAEF6DD374" modified="2015-06-24" version="1">MRRRLAAALIVPALMLTAACGGGDDSGKKDSSPSAGASKPAEVPKPVASADPMPTVAGEAGKKAEITVPKGEPSGKFVVNVLKEGTGPEVKKNDLVIAKFTGKIWKSGKDLPSSYDQGGEPLPFTAGSPQTLPLFGDSVLGKKVGSRLLVVAPPAAAFGDQGQPKLGVGAKDNLVFVIDVDQVVPKKAEGTQAPIPSDLPQVKADEEKEATITVPKNDPPKELVDKVLIEGKGPEVKSGQTVFMQYSGATWVPNEGKEAATLFDNSWKTGQPFSTQIGTGQVIQGWDKGLVGKKVGSRVLLVIPPEQGYKDQAQGEIPANSTLVFVVDILGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNW6</accession>
    <name>A0A0F4JNW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_08670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946815.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36057">
        <property type="protein sequence ID" value="KJY36057"/>
        <property type="gene ID" value="VR44_08670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4978"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26557" checksum="F97967327CE645EC" modified="2015-06-24" version="1">MTAPSGVVLDTDGVLLATAPHHAAAWKEAFDGCLAHWSTRRPGGAGARPFDAAREYRELVDGRSRLDGVRAFLTARGITLPPGTPEDPPGCDTVRAVAARKERAFAGMVRTAGADAFDDVRPALRRLREMNLGCAAVSASRHARSLLEAADLIGLLDVVVDGEDAAALSLPGKPAPALFLEAARRLGVEPGRAAVVEDALAGVEAGRRGGFRPVVGLARDRDPRTEHALRAHGADLVLPGLGGLPAALEAFTGGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP23</accession>
    <name>A0A0F4JP23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">VR44_10050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947072.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35498">
        <property type="protein sequence ID" value="KJY35498"/>
        <property type="gene ID" value="VR44_10050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5609"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="9940" checksum="19B2D70ADD5D94F1" modified="2015-06-24" version="1">MIGNLKPLEILLIIAVIVLLFGAKKLPEMARSLGKSARILKSEAKAMKRDGEAEDAPAAAPAADTQQPVAPRTIQAAPGDVTSSRPVGEPGRTAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP71</accession>
    <name>A0A0F4JP71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000214">
        <property type="protein sequence ID" value="KJY35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947055.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000214.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7037"/>
    <dbReference type="EnsemblBacteria" id="KJY35548">
        <property type="protein sequence ID" value="KJY35548"/>
        <property type="gene ID" value="VR44_09955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="503" mass="55603" checksum="9055D27FC1D34C78" modified="2015-06-24" version="1" fragment="single">MTTTASHHLSPAFPGRAPWGTASKLRAWQQGALDKYIQTQPRDFLAVATPGAGKTTFALTLASWLLHHHVVQQVTVVAPTEHLKKQWAEAAARIGIRLDPEYSAGPLSKDYHGVAVTYAGVGVRPMLHRNRCEQRKTLVILDEIHHAGDSKSWGEACLEAFDPATRRLALTGTPFRSDTNPIPFVTYEEGNDGIRRSSADYTYGYGNALGDGVVRPVIFLSYSGNMRWRTKAGDEIEARLGEPMTKDAISQAWRTALDPRGDWMPNVLRAADQRLTEVRKGIPDAGGLVIAADQDAARAYAKLIREITGTKATLVLSDDAGASKNIDTFSGNDERWMVAVRMVSEGVDVPRLAVGVYATTISTPLFFAQAVGRFVRSRRRGETASVFLPTIPYLLGFANEMEVERDHVLDRPKKAGEDEDPYAESEKEMEEANRQEDEDTGEDEQMSFEALESDAVFDRVLYDGAEFGMQAHPGSEEEQDYLGIPGLLEPDQVQLLLQKRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPA2</accession>
    <name>A0A0F4JPA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000207">
        <property type="protein sequence ID" value="KJY35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946964.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000207.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35674">
        <property type="protein sequence ID" value="KJY35674"/>
        <property type="gene ID" value="VR44_09475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5296"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_7" evidence="1">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="19707" checksum="8F61CAEDA35EC023" modified="2015-06-24" version="1" fragment="single">GHCTAEATAVEAGLAAADVGRHFPDHEQLLLGVLLDSSASVAASLAAVAESYLAEIHDLREDLIALGRAWLAPLEAFREHFAIVRHISAEVTHLPAEAVDKWQATGPRQARRELARRLQQVAARGLLDIADADQAAERFILLVPSSVVQRSFHGALPLGRVEEDALIADGVDDFIRLYGPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPF5</accession>
    <name>A0A0F4JPF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946998.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35633">
        <property type="protein sequence ID" value="KJY35633"/>
        <property type="gene ID" value="VR44_09665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5381"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009677">
        <property type="entry name" value="DUF1266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06889">
        <property type="entry name" value="DUF1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="401" mass="44408" checksum="9AC40D596FE6DD91" modified="2015-06-24" version="1">MDEWTAPSVIERELYGAKARGDWGAYMDALARAELFLPQPRAQIDADPAAARFHPDAANTLAVYTRGMLPAPDAHTVYLRQSLAWFANAWDHRDPSHLAVNPGSPVEAYLTTTPADLARWRAHWDAADSWGLAPGAVHALHTGGPLHGPVARGLAVGAHLAVSNGEFWNALAYHGNGYTRERERLRTMWEIDDAAGWFAVLQRMLNAEIVSPVWEFALRVRRVLASDFAGPVDVEHWRHAAEVSLRRSAELAAQPRLTPDGVTVAEPRPAAEVEGEIAGVRRLIGRITRYEQRFRADGLLPAGGWVRSVEGWDYGRASQMARWGVACRYGTVQDAERAVLRAGRQALGAYRSWAEFSAGYALARCLHFDEEEFGSWYESSLATHLTLTTDPASPFLNIPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQE5</accession>
    <name>A0A0F4JQE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36069">
        <property type="protein sequence ID" value="KJY36069"/>
        <property type="gene ID" value="VR44_08760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4996"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="367" mass="37108" checksum="02875758954F6B82" modified="2015-06-24" version="1">MRGPPEAAPEAERGGGAAAAHDQQVGVVGRLDEDTGHGDALLRFALDDQVGELLADHVRDGEEGLLVPAGDLVHAVEHGHDGADGLEHVPDVQQPQRRLAQLGFPGRVLGARQVVLVADGGEDAAAFLRPLDAAHHDDGGPGGRRRVEADGAEHERIEAAQAAVAHDDGAVQAGGPVQAGDGVGAAELGGDGQPRILGGHGLGRVVQEFPARGTDPLDALRRQVEGPAVGVGTVDDVQGAATALGLRRGPQGGVARLRRAVHADDDGAGVGGTDGAFHGSSQPRSRRVSPLTLAPPGAGKEGRQGPAGGPKVPIGPARSRPARRGGSSRSPDGTVRPSKRGSAPADGEWQHRTPATPTAGTAEQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRK5</accession>
    <name>A0A0F4JRK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_06810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946470.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36982">
        <property type="protein sequence ID" value="KJY36982"/>
        <property type="gene ID" value="VR44_06810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3442"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="36120" checksum="F5FCA9AAC30BE5E9" modified="2015-06-24" version="1">MPDPVSTLTESRPRPAVPAGGPAPARQGPRGLRSWASVAWFLVPALVLFLVFVLAPIGVAVYTGLFKWGGAGPMDEFVGLENYTRLFHDRVFLGDLERGLYLIVLSVTVQLPFALFTAVLLNQRLRGRAFYRMLFFAPYVLSEVVTAVLFTMVFLPGTGMADHLAGALGLEGLRGKWLADPSTVVPTLFVVMTWKYFGFHMMLFLAGLQSIPDEVLEAASIDGAGVWQRFRHVTLPLLGPTIRISVFLSVIGAIQLFDLVWVMTAGGPNHSSETMAISMFQFGFKRYQVGYAGAISVVLFMISVVFSLFYQRYVLRRDLSGAITPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRM0</accession>
    <name>A0A0F4JRM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000213">
        <property type="protein sequence ID" value="KJY35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35581">
        <property type="protein sequence ID" value="KJY35581"/>
        <property type="gene ID" value="VR44_09890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5525"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471290" evidence="2">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="16167" checksum="C38B8B1FF30BD1B6" modified="2015-06-24" version="1">MTCWRATTRPATWRPGRRSAATCAAAPATRASSRRSARSSRSARPPPLRRRRAWPRKPRRRRSSRTRHSPAKAACTASTPLHRAPTGPSAATASTSRARSTRPAASTRRCPARTAPWAATASRWRPASTPPRPARTAPSAATASTRPACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRZ9</accession>
    <name>A0A0F4JRZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37142">
        <property type="protein sequence ID" value="KJY37142"/>
        <property type="gene ID" value="VR44_06365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3182"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="26361" checksum="E45C39596D51C8E5" modified="2015-06-24" version="1" fragment="single">PGTTSPAGTPAPGSAPALAHARVGTAAPAAPAGTAPQAPAGGGAHGMAAPAAAGAPAGAAQTRPTAGGTGWGGPDMGAPATFVLLRHGETALTPQKRFSGSGGTDPEQAVVSSPLRRCRETAQAVADRLGLPVTVEEGLRETDFGAWEGLTFAEVRERFPDDLQAWLDSPKAAPTGGGESFAAVTRRVSATRDRLLSAYAGRTVLLVTHVTPVKTLVRLALGAPPESLFKMELSAASLSAVAYYADGNTSVRLLNDTSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSG2</accession>
    <name>A0A0F4JSG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000138">
        <property type="protein sequence ID" value="KJY36769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946546.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36769">
        <property type="protein sequence ID" value="KJY36769"/>
        <property type="gene ID" value="VR44_07265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3794"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="532" mass="56457" checksum="E06D8691E2085C87" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSK3</accession>
    <name>A0A0F4JSK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946400.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37155">
        <property type="protein sequence ID" value="KJY37155"/>
        <property type="gene ID" value="VR44_06435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3199"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="24020" checksum="87EAD7DFE0A1A84B" modified="2015-06-24" version="1">MDTIEYKDEGDTIAVTVRMPKAEVAAERQEDEPESTAAQAVAFTHLANLFSENLRDSLSQAEAAADMALTYVARHGDDVHFVGRFVALSKIRHMMRQRWTTAPIPWAKLHSEGDWDTRLHEMIGRRILLEVHEDGLVPVAMEATAEGDVDVTASSDEKAARSLAPAYVVTPEQLADALPAKCTLGRKSAADILAALSAAGTTTATHDDVVEALRAEREGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT92</accession>
    <name>A0A0F4JT92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000123">
        <property type="protein sequence ID" value="KJY37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946444.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000123.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37039">
        <property type="protein sequence ID" value="KJY37039"/>
        <property type="gene ID" value="VR44_06655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3249"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="27129" checksum="D46313310C5B6838" modified="2015-06-24" version="1">MGSESGRVKRGEQSRISQWLRRRSKPTPEDPGREREALLVAVAAAGLPVAPAAHPVGYRCSCDRIGCPTPARHPVSFAWQTQSTTDRAQIERWARNQPQANFITATGMVHDVLDVPLEAGRSALDRLLAAGVEVGPVAESGGTGDQARMLFFTATRGTPEDEDEWWPCELDCHPETMDEHPGLRWHCRGSYVLLPPAALPGDFAVAWVRDVRHPLPDPLTLLETLTDACAQYAGAADQTPSAVAWPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVA2</accession>
    <name>A0A0F4JVA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_04985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000093">
        <property type="protein sequence ID" value="KJY37774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946131.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene179"/>
    <dbReference type="EnsemblBacteria" id="KJY37774">
        <property type="protein sequence ID" value="KJY37774"/>
        <property type="gene ID" value="VR44_04985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1312"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="164" mass="17986" checksum="07B356B35C46E408" modified="2015-06-24" version="1">MLEPLRQGLPPVDPTAVSGSASCALPARFEAVRGARSFTRSTLSQWGLDERFDDVALVVSELVTNALRHALPDEARPCGGEQPEAAAVRLHLMRWSTRLVCAVRDPSEDRPGGSFAPERTDENCDLESGRGLFLVDSYSDSWGWHPLAGRLTGKVVWALFLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWV4</accession>
    <name>A0A0F4JWV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_03915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000073">
        <property type="protein sequence ID" value="KJY38228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945935.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38228">
        <property type="protein sequence ID" value="KJY38228"/>
        <property type="gene ID" value="VR44_03915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8688"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="46179" checksum="588AABBAA04620BB" modified="2015-06-24" version="1">MASAITTLAADTPTLSAANTGFMLICSALVMLMTPGLAFFYGGMVRVKSSLNMLMMSFVSLGIVTILWVLYGFSLAFGTDSGSVIGWNSDYVGLSGIGLTELWDGYTIPVYVFAVFQLMFAVITPALISGALADRVKFSAWVLFTALWVSVVYFPVAHWVWGAGGWLFKLGVIDFAGGTAVHINAGAAALGVILVIGKRVGFKKDPMRPHSLPLVMLGAGLLWFGWFGFNAGSWLGNDDGVGAVMFVNTQVATAAAMLAWLAYEKLRHGSFTTLGAASGAVAGLVAITPAGGCVSPLGAIAVGAIAGVLCAMAVGLKYKFGYDDSLDVVGVHLVGGVAGSLLIGLFATGGVQSDAKGLFYGGGFEQLGKQAVGVFSVLAYSLVVSAIMAFLIDRTMGMRVAEDVEVSGIDQAEHAETAYDFSGAGGGISARPAASHAPVAAANKKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX39</accession>
    <name>A0A0F4JX39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_05495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000101">
        <property type="protein sequence ID" value="KJY37541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007262967.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7154"/>
    <dbReference type="EnsemblBacteria" id="KJY37541">
        <property type="protein sequence ID" value="KJY37541"/>
        <property type="gene ID" value="VR44_05495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1736"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY37541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16785" checksum="1DD927D49BD1DF3A" modified="2015-06-24" version="1">MRLNDLDERIVHALAEDARRSYADIGSEVGLSAPAVKRRVDRLRAEGAITGFTVRVDPAAMGWETEGFIEIYCRHNTSPDDIRRGLERYPEVVSASTVTGDADALVQVFASDMRHFERVLERIAGEPFVERTKSVLVLSPLLRRFTSGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX45</accession>
    <name>A0A0F4JX45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Formamidopyrimidine-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_03840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000070">
        <property type="protein sequence ID" value="KJY38328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945923.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38328">
        <property type="protein sequence ID" value="KJY38328"/>
        <property type="gene ID" value="VR44_03840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="12">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY38328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="257" mass="28264" checksum="773B23F51ED10032" modified="2015-06-24" version="1" fragment="single">MPELPEVEVVRRGLERWVAGRTVSAVEVLHPRAVRRHPAGGADFAARLAGGTIGVPHRRGKYLWLPLEGQELSVLGHLGMSGQLLVQPADAPDEKHLRIRVRFADDAGTELRFVDQRTFGGLSLHEVVAGSEEGLPDVIAHIARDPLDPLFDEGAYHLALRARRTTLKRALLDQSLISGVGNIYADEALWRAKLHYERPTATLTRPRSTELLTHVREVMNAALAVGGTSFDSLYVNVNGESGYFDRSLDAYGREGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXG8</accession>
    <name>A0A0F4JXG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_03550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945874.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38423">
        <property type="protein sequence ID" value="KJY38423"/>
        <property type="gene ID" value="VR44_03550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8248"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="28548" checksum="B10E3506A4A39693" modified="2015-06-24" version="1">MSTYDDDLRLALELADAADAATMQRFRALDLKVETKPDMTPVSEADQAAEEIIRAGILAARPDDAILGEEYGLKGEGPRRWVVDPIDGTKNYVRGVPVWATLISLMEEGEDGEFRPVVGVVSAPALGRRWWASQGGGAFSGGALGEPAGPIGVSKVASLADASFAYSSLTGWEELGRLPGFLELTRACWRTRGYGDFWPYMMVAEGSLDLCAEPELNLWDMAALAVVVQEAGGRFTSIDGVDGVHGGNAAASNGLLHGEMLDFLRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY69</accession>
    <name>A0A0F4JY69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_02800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000049">
        <property type="protein sequence ID" value="KJY38794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945739.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4862"/>
    <dbReference type="EnsemblBacteria" id="KJY38794">
        <property type="protein sequence ID" value="KJY38794"/>
        <property type="gene ID" value="VR44_02800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7290"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY38794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="29512" checksum="C589ACC8115C59B6" modified="2015-06-24" version="1" fragment="single">GATDLDSQLAVDLDKLVVMGRMAKRRLIESNLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTAEEVAVHLELTPERVLEVLRLAQEPVSLHAPVGEEEDVALGDLIEDGDAASPMESAAFFLLREHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLAKLRDHAFADQLRGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYF8</accession>
    <name>A0A0F4JYF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000028">
        <property type="protein sequence ID" value="KJY39165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945602.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39165">
        <property type="protein sequence ID" value="KJY39165"/>
        <property type="gene ID" value="VR44_02065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5821"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26760" checksum="FE6DDB7CCCF49F32" modified="2015-06-24" version="1">MSPHPHPFRLALVTGANRGIGFETARRLAAEGVRVLLSGRDRAAVAAAAGELRDAGLPVEPLVLDVTDGDGVLAAAAEVERSYGRLDILVNNAAIRVEEYGRKPSEQPLEQWRRTFDTNLFAVVEVTRAFLPLLRRSPAGRIVNLSSLLGSVGTHGDPASYAYSDMFKSLPAYSASKSALNSWTVHLAYELRDTPVKVNAVHPGYTRTGLNDGEGDLSVQDGARTGVAMALLGDDGPTGTYTHRGETVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYL0</accession>
    <name>A0A0F4JYL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="7">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VR44_04315</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000079">
        <property type="protein sequence ID" value="KJY38076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946019.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38076">
        <property type="protein sequence ID" value="KJY38076"/>
        <property type="gene ID" value="VR44_04315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.430"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02077">
        <property type="entry name" value="P-type_ATPase_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="18">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJY38076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="913" mass="99091" checksum="C0F290E4F7A3074C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZJ5</accession>
    <name>A0A0F4JZJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR faimly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000067">
        <property type="protein sequence ID" value="KJY38416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945902.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5780"/>
    <dbReference type="EnsemblBacteria" id="KJY38416">
        <property type="protein sequence ID" value="KJY38416"/>
        <property type="gene ID" value="VR44_03715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8281"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="321" mass="34849" checksum="83989C91453CE696" modified="2015-06-24" version="1">MRALLVANPAATTTSARTRDVLTHALASEMKLEAVTTEYRGHARDLGRKAAHEGLDLVVALGGDGTVNEVVNGLLHDGPDPERLPRLAVVPGGSTNVFARALGLPNDSVEATGALLDALRERRERTVGLGLAEGVPGTEDEGVPSRWFTFCAGFGFDAGVVGRVEQQRERGKRSTHALYVRQLMRQFWEEPNRRHGTITLEQPGADPVTDLVLSIVCNTSPWTYLGNRPLYASPEASFDTALDVLALDRLSTPAVARYATQLLTSTPERGPRGKHAVSLHDLTDFTLHSKVPLPFQMDGDHLGVRTSVRFTGVRRALRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZN8</accession>
    <name>A0A0F4JZN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">VR44_01145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000015">
        <property type="protein sequence ID" value="KJY39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945429.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4714"/>
    <dbReference type="EnsemblBacteria" id="KJY39580">
        <property type="protein sequence ID" value="KJY39580"/>
        <property type="gene ID" value="VR44_01145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2943"/>
    <dbReference type="eggNOG" id="COG1859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19920" checksum="1C97279FA007D8C2" modified="2015-06-24" version="1">MDDRRTVKVSKYVSKHLRHQPERIGLTLDPQGWVEIDDLLRAAAAHRFPFSRAELDHVVATNDKKRFAVDGTRIRASQGHTVEVDLELPEAEPPAYLYHGTVASALDSIRAEGLRPMGRHHVHLSPDRETATRVGARRGRPVVLSVDAGAMRAAGHVFRVSANGVWLADAVPPEFLRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZQ8</accession>
    <name>A0A0F4JZQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945554.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39324">
        <property type="protein sequence ID" value="KJY39324"/>
        <property type="gene ID" value="VR44_01860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5776"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="43621" checksum="5198FF266756EB3E" modified="2015-06-24" version="1">MTGLRGLAAILVFGFHFTTFQFVFGPTGGLEFAPLTRPRFLTMSGNFAVGSFFILSGFVLALTTREGTSLANFCAKRVGKLYPVYFVTTALAIGAIVVLGMPITTENIVLHLTLLQSWVPFQEIYTGVNPVTWSLSTEAFFYLLFPLALFVVQRLSTRALYWVLGTAVFLEFALPLYVMHYFTVKTSGGHLQYFSTGSQGGDLVYWLTLPFPPYRFLEFLVGMVCCVLLNRGVLPTIRQRWAWAWCAVAYVIGTYLDGPLQRTAVGLVALPFLVVALAQADLAGRWSLLRGKVFVGLGKLSYGMYAIQLLVVLPSEPFVMRWLSSLFGVSASTLGEPLWKVLVMAAYFGVVILLSVPIYRYIEVPAYDFAKRLYRSRKGSPMFAAPESAGKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K187</accession>
    <name>A0A0F4K187_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_02565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000040">
        <property type="protein sequence ID" value="KJY38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945698.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38971">
        <property type="protein sequence ID" value="KJY38971"/>
        <property type="gene ID" value="VR44_02565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6817"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="339" mass="35773" checksum="D7157A2D1DE6101F" modified="2015-06-24" version="1">MNGQRERKDATAVPADDGRPVLEIDGLGVRLPDDRARRPILDGVDLRVRPGESVGLVGESGSGKSVACRSVLGLLPAGARTSGEVRVAGRDVLAMSRSELAGLRARQVAMVYQDPRASVNPLRRVGDFLTEGLRAAGTPAATADARALELLDAVGIRDPRGALRRRPHEFSGGMLQRVVIAAALAAEPALIVADEPTTALDVTTQAEIVELLARLRAERGTGLLFVTHDLELAATVCDRVYVMYAGRIVETRGTDELFDRPRHPYTAGLLACTPGIEAGAPAPRPIPGRPVSLAEAPPGCAFAARCAHALPRCSEEKPALTRHGDGLAACHRADEGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K294</accession>
    <name>A0A0F4K294_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000002">
        <property type="protein sequence ID" value="KJY40063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945259.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY40063">
        <property type="protein sequence ID" value="KJY40063"/>
        <property type="gene ID" value="VR44_00085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.17"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY40063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="167" mass="18061" checksum="97FDC1B884E33292" modified="2015-06-24" version="1">MGDGNWQVGAAEGGRLAARWWKWALSAPEGESPVADTTGAYAGRRQPEDVWFLAGTHGGRVVRRCGVPTGRPLFFPVLNTRRAAVPFLTKPWRLEATRASAALNGSPLPLREFTSKPFPVLGIPQVAWGLWCALDPLPPGQFVLEIDAAATNGFRVDTTYHLAVTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2B1</accession>
    <name>A0A0F4I2B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001798">
        <property type="protein sequence ID" value="KJY16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16047">
        <property type="protein sequence ID" value="KJY16047"/>
        <property type="gene ID" value="VR44_40625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6992"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="7902" checksum="8459BF5329B7C4A4" modified="2015-06-24" version="1">MLARAGSVLPVRRADGSVGLEAWAPARGRTGGGVVIRDPGPGFGAGEVERYTVRWAGEAVVVEDEAGGVVSGVEVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5H4</accession>
    <name>A0A0F4I5H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001722">
        <property type="protein sequence ID" value="KJY16723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16723">
        <property type="protein sequence ID" value="KJY16723"/>
        <property type="gene ID" value="VR44_40310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="26088" checksum="09ED0E7F2510DF7C" modified="2015-06-24" version="1" fragment="single">PLTSVPADRPLTAVVHAAAVVAGGLVDTLTAEDLDQVLRPKVDAALNLHELTRGLDLSAFVLFSSLAGTLGGAGQGAYAAGNAFLDALAHQRRAQGLPASALAWGVWDERGDQTRLADGDLRRMARAGLVPLTADEGLRLLDTARTLDDAALAPVRLDLPALRRQSAGPAPALLRALVRAPGRRAAQSAAPGPGGLSAELSRLAALPPAERKDTVLTLVRNQVAAVLGHATPAAIDPGRAFRELGFDSLAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8U4</accession>
    <name>A0A0F4I8U4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001691">
        <property type="protein sequence ID" value="KJY17116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17116">
        <property type="protein sequence ID" value="KJY17116"/>
        <property type="gene ID" value="VR44_40140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6401"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="159"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="354" mass="36942" checksum="02D73266EEE07A07" modified="2015-06-24" version="1" fragment="single">EPSPHIDWTSGAVRLLTEPVTWAEDGRLRRAAVSSFGVSGTNAHTIIEQAPALPEPAQEAPAPAADPLPVAWTLSARDTTALREQAERLLRHLLGLGEVSPVDVAHSLATSRAVLEHRAAVVGTELPDLVAGVTALAAAEPAAQLVEGVGGREAATAFLFSGQGSQRLGMGRELYAAHPEFASAFDAVCTALDPHLERPLKDVVFGQDAELLERTEYTQPALFAVEVALFRLLESWGVRPDYLAGHSVGEYAVAHAAGVLTLPDAARLVALRGRLMQALPAGGVMVAVQASETEAGELLAGLEDRAGVAAVNGPHSVVVSGAADAVATVVDRLRAQGRRTKGLAVSHAFHSPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAL1</accession>
    <name>A0A0F4IAL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_39260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001569">
        <property type="protein sequence ID" value="KJY19017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19017">
        <property type="protein sequence ID" value="KJY19017"/>
        <property type="gene ID" value="VR44_39260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5653"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469316" evidence="5">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY19017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="80" mass="7509" checksum="154CB32D9904FBD7" modified="2015-06-24" version="1">MMRGTTVALAGAALLMGGAGLASAHGGDGATADGLAAGSPGVLSGNLVQVPVDVPVNVCGVTAQLIGLLNPAFGNHCVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAQ9</accession>
    <name>A0A0F4IAQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001601">
        <property type="protein sequence ID" value="KJY18558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18558">
        <property type="protein sequence ID" value="KJY18558"/>
        <property type="gene ID" value="VR44_39545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6000"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12504" checksum="209C15D8705900F0" modified="2015-06-24" version="1" fragment="single">MITSTVEESWDRIESWLARHAPITHGLLRPAAVLADITAAEARLGVAFPPDLRESLLRHDGVELQDGTLRLDYYGPLSGVEEIVRSTEFLRGVGEGLAEEEADLDEGERDEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IDU5</accession>
    <name>A0A0F4IDU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001535">
        <property type="protein sequence ID" value="KJY19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19849">
        <property type="protein sequence ID" value="KJY19849"/>
        <property type="gene ID" value="VR44_38950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5506"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9824" checksum="AEA0AB04A1D8993B" modified="2015-06-24" version="1" fragment="single">MSEQYEYVPHRLLRRRVRDIASGTEGELMAVINENVSDSLTYERWMELAYIRAASGREFTTAVENVIPAYDQPQPTRRRRDFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGX9</accession>
    <name>A0A0F4IGX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001462">
        <property type="protein sequence ID" value="KJY21300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21300">
        <property type="protein sequence ID" value="KJY21300"/>
        <property type="gene ID" value="VR44_38330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5276"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="550" mass="57694" checksum="305D1DB6141E2B1A" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IJR1</accession>
    <name>A0A0F4IJR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001427">
        <property type="protein sequence ID" value="KJY22265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952239.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001427.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22265">
        <property type="protein sequence ID" value="KJY22265"/>
        <property type="gene ID" value="VR44_37990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5163"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY22265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8016" checksum="CB18FD876A61F77E" modified="2015-06-24" version="1">MSLTASAGMTLWGLTYFALQYLLAAGRVVSAPAFAAKDADHARGLSAPTSVAAADRACLCPVTRLTFAAVTAARDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IM99</accession>
    <name>A0A0F4IM99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001414">
        <property type="protein sequence ID" value="KJY22608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22608">
        <property type="protein sequence ID" value="KJY22608"/>
        <property type="gene ID" value="VR44_37835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY22608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="259" mass="27417" checksum="043F072AE62E602C" modified="2015-06-24" version="1" fragment="single">MSVALRTPARPGEPLLARAPRRWQRMAPFAVAAVFVVVLLPVTIAVLTNDYRLGGGWAGALGVAQTVPLLLAVTRPVPAWAAVLAADLLGAVLLASADGVAGRPWPWPPMEIVGYLVLMACLGLRESVRTLVGVWLATGAVGVVLGFFAPGGVTDTVALLFVLGGVMLALTGALRGLGDAQQRIAEQESISEAERARRTLLEERARIARELHDVVAHHMSVITVQADSAPYRLPGMEEPVREEFAAIAASARESLGEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP01</accession>
    <name>A0A0F4IP01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001371">
        <property type="protein sequence ID" value="KJY23752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23752">
        <property type="protein sequence ID" value="KJY23752"/>
        <property type="gene ID" value="VR44_37380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4895"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19842" checksum="D950D0B3B5BB8DF2" modified="2015-06-24" version="1">MISYGRAVLDLADELLDAYADVFSAPPWNEDEETIRQFADRLQADVRRPGFRTAFTQSPAGVDGFATAWLTQRPFPEGRGYPQVTAQLGPDRVRDLLVGALEIDELAVRAHARGTGTGRALLTEITADAPQHRAWLLTSRLAQDTVATYRRLGWHEVPALPGTETNVVVFLSPNHPGRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRG4</accession>
    <name>A0A0F4IRG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kynU</name>
        <name evidence="7" type="ORF">VR44_34835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="JZWV01001194">
        <property type="protein sequence ID" value="KJY24610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951647.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001194.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24610">
        <property type="protein sequence ID" value="KJY24610"/>
        <property type="gene ID" value="VR44_34835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4038"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="165"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="412" mass="43634" checksum="00BA2CE55C44607B" modified="2015-06-24" version="1">MSDAILQDPQDPQDPQDLQDLQARAARLDAEDPLAKHRERFTLPEGVVYLDGNSLGALPAGVPGAVADVVHRQWGELLIRSWDESGWWTAPERIGDRIAPLIGAAPGQVTVGDSTSVNLFKALVGAARLAAPGRTRMLVDATTFPTDGYIAASAARMTGLDLVPVDPSEAAAAMDDRTAVVLLNHVDYRTGRLHDLPALTGAAHAAGALIVWDLCHTAGALPVGLDAHAVDLAVGCTYKYLNGGPGSPAYIYVAERHQGAFDSPLPGWNSHAEPFAMTPEYAPAQGAARARVGTPDILSMLALESALDAWEDVDIEAVRAKSLALTDFFLECVAAYVPAGAVEVVTPLEHARRGSQVSLRTDGARAVMTELISRGIVGDFRAPDVLRFGFTPLYVGFADAERAARTLGHIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRN8</accession>
    <name>A0A0F4IRN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001188">
        <property type="protein sequence ID" value="KJY24657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951616.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001188.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24657">
        <property type="protein sequence ID" value="KJY24657"/>
        <property type="gene ID" value="VR44_34670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3923"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="28980" checksum="2280EA4D9B101358" modified="2015-06-24" version="1">MNETSAALATARWPLTAAGETDWLRELADDDGLTGFMPPALPDAAWVLHSMYEHELGPTDMSYVAYQRAVLNGGGPEVIPGLDPADVFGGTPGEPPSPRWRRLRWAELSERTGDPVAPEGRLPCYRSFPSLREPSGWPVGIAGPSEGSLDRTDWNRLVDILTEHSPQGPQTRCMAYYNPLLQRAEDFDNLHVRAGTLADAKALYDHPEEDGWTPSNLWAQDRSWVLCTDYDLWATKVAGPAPLVEALLNDTEIEALRLPWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISG3</accession>
    <name>A0A0F4ISG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_33890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001144">
        <property type="protein sequence ID" value="KJY24945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951477.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001144.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24945">
        <property type="protein sequence ID" value="KJY24945"/>
        <property type="gene ID" value="VR44_33890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3704"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="189"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY24945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="41386" checksum="9EDCDBC732E51F63" modified="2015-06-24" version="1">MDNGPCTGLAAVSTALLAMSRRLEVRDVLRTIVVSARELLDAEYAALGVPDDHGGFAQFVVDGITEDQWRRIGPLPRQHGILAAMLHQDGPQRLADVRQDPRFEGWPAAHPDMSDFLGLPVRDGDEVLGALFLANKRRAPGAQHGSPHGFTDEDEELLSLLAQHAAIALTNARLYERSRELTIAEERSRLAHELHDAVSQKLFSLRLTAQAAAALVDRDPARAKGELQQVAALAAEAADELRAAVTELRPAALDEDGLVATLRNHVRVLDRAHTARVTFTCDGVRALPAAQEEALLRVAQEALHNALRHSGADRVEVTLARAPGGGALLRVRDWGKGFSPPTVRKAGRHLGLVSMRDRAAGAGGRLEVRSEPGAGTTIEMEVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISK1</accession>
    <name>A0A0F4ISK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001191">
        <property type="protein sequence ID" value="KJY24634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24634">
        <property type="protein sequence ID" value="KJY24634"/>
        <property type="gene ID" value="VR44_34755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4019"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="29597" checksum="DF58A9027535CD28" modified="2015-06-24" version="1">MAPSARRTAGTMFAALYGELVPHAWRDPASEHDAYQLFHQRSLAMGWLDDRAGAEEVSAAGRRTHAAPGLWAMNDAGWSHPLAAPRPNLISWFQVEVSALPDDRPLPVQPFLRCAQDTTERVGAVRLTAVQILLPVQGIEASARPPYALVPSMRTSDWFGECDPQARVPVKVRIDGGVDRSIPMVAPQLARHVVPADQNVFAGEIDEVLPLGEFPAPPFDDRFWNGPPLHGMTLSGELAEWSCDAVGWLAATVADSAAHLGIHTPVLFTVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT10</accession>
    <name>A0A0F4IT10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951373.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25132">
        <property type="protein sequence ID" value="KJY25132"/>
        <property type="gene ID" value="VR44_33325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3541"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6756" checksum="162DFF67C3F55D50" modified="2015-06-24" version="1">MRKVMDCREYPSEVGCTLTIIGEEDEVMDAAVQHAVAVHGEEDTTEFRDALRGMLKTEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT32</accession>
    <name>A0A0F4IT32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VR44_33215</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001113">
        <property type="protein sequence ID" value="KJY25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25165">
        <property type="protein sequence ID" value="KJY25165"/>
        <property type="gene ID" value="VR44_33215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrA_inter" evidence="15">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="UvrA_DNA-bind" evidence="14">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="381" mass="42539" checksum="3150347D78DBD434" modified="2015-06-24" version="1" fragment="single">MLYARKSRPSPSQRRPPYPGQPGARAPALSRKVRTGVTDRLIVRGAREHNLKNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARIGKPHCPECRRPISRQSPQAIVDKVLALPEGSRFQVLSPLVRERKGEFVDLFSDLQTKGYSRARVDGQTIQLSEPPTLKKQEKHTIEVVVDRLTVKDSAKRRLTDSVETALGLSGGMVILDFVDLAEDDPERERMYSEHLYCPYDDLSFEELEPRSFSFNSPFGACPECTGIGTRMEVDPELIVPDEEKSLDEGAVSPWSLGHTKDYFQRLVGALAGELGFRTDIPWAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITK5</accession>
    <name>A0A0F4ITK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001166">
        <property type="protein sequence ID" value="KJY24813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951544.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001166.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24813">
        <property type="protein sequence ID" value="KJY24813"/>
        <property type="gene ID" value="VR44_34260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3827"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116859" checksum="BCF21FFBEF390A90" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITU6</accession>
    <name>A0A0F4ITU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001125">
        <property type="protein sequence ID" value="KJY25069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951413.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001125.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25069">
        <property type="protein sequence ID" value="KJY25069"/>
        <property type="gene ID" value="VR44_33525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3585"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="21940" checksum="7B70F30D9435502A" modified="2015-06-24" version="1">MSGVSPSPAEQHLGDRLAALVDGELKHDARERVLAHLATCARCKAEADAQRRLKTLFVESAPPPLSAGLLARLQGLPGTGPEGPAGPPGGPGAPRTPAAPGADPLATFGYAVPAAPREGFRIHEMGRPRRRLAFVAAGAVSLAAIALGGSLPLDAIEPNARGEAPASRPGPSIPLTDAAIRDRLPLPDAVRTPSPSAATPTAVSPPPVTAQPASLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITV4</accession>
    <name>A0A0F4ITV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatB</name>
        <name evidence="11" type="ORF">VR44_33510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001124">
        <property type="protein sequence ID" value="KJY25079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951409.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25079">
        <property type="protein sequence ID" value="KJY25079"/>
        <property type="gene ID" value="VR44_33510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3582"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY25079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16258" checksum="6627C45A8690D6ED" modified="2015-06-24" version="1">MFNDIGALELVTIVVLAILIFGPDKLPKVIQDVSGFIRKIRAFSDSAKQDIRSELGPEFKDFEFEDLNPKTFIRKQLTENEDLQELRSSFDLRKELNEVTDAVNSRDTGPVPSAAPASATPAAGTGPDLLKKPAAPAVETRTPFDADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUS4</accession>
    <name>A0A0F4IUS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ORF">VR44_33045</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="JZWV01001104">
        <property type="protein sequence ID" value="KJY25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951320.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001104.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene108"/>
    <dbReference type="EnsemblBacteria" id="KJY25233">
        <property type="protein sequence ID" value="KJY25233"/>
        <property type="gene ID" value="VR44_33045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3481"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY25233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="616" mass="65002" checksum="EE20D3902FF153A9" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVS4</accession>
    <name>A0A0F4IVS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_30795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000978">
        <property type="protein sequence ID" value="KJY26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000978.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26135">
        <property type="protein sequence ID" value="KJY26135"/>
        <property type="gene ID" value="VR44_30795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2616"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="314"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="573" mass="59981" checksum="07426DF5D2CECEBC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW44</accession>
    <name>A0A0F4IW44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001036">
        <property type="protein sequence ID" value="KJY25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25678">
        <property type="protein sequence ID" value="KJY25678"/>
        <property type="gene ID" value="VR44_31850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3083"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16301" checksum="4CE777C00FD9C89D" modified="2015-06-24" version="1" fragment="single">TTAMGYCYPRGAVVGGDPDRPIIPETMRLKGDVGTRAPHMWLTRAGQRVSLLDLYETSFVLLSSPGTPWKEAAGQVARELGAHLDAYTIGSAPDADLVQPDGADWAELHELAADGAVLVRPDGFVAWRAEHTPADPRGELLDAMTRLLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWI9</accession>
    <name>A0A0F4IWI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000945">
        <property type="protein sequence ID" value="KJY26392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950796.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000945.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000005_gene4051"/>
    <dbReference type="EnsemblBacteria" id="KJY26392">
        <property type="protein sequence ID" value="KJY26392"/>
        <property type="gene ID" value="VR44_30185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2442"/>
    <dbReference type="eggNOG" id="COG0374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="594" mass="66758" checksum="3B0F2A6618929762" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXD8</accession>
    <name>A0A0F4IXD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_30310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000954">
        <property type="protein sequence ID" value="KJY26319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26319">
        <property type="protein sequence ID" value="KJY26319"/>
        <property type="gene ID" value="VR44_30310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2472"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="209"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="404" mass="41383" checksum="70D1C4BE6CE66BC7" modified="2015-06-24" version="1">MWAADTVSQAGTAVTLLALPLLAVGTLNATPLQAGLLVACEYLAFLLVGLPAGAWVDRSRHRRVMVAGDLARAVLLASVPVTALLDALTLAQLYAVAFGLSLCAVFSDVAAQSVLPRLVDGERLMEANTRLEATRSLVQAAGPGLGGVLLAVVAAPVALAFDACSRLASALLLARVRPTPAPPAPGQGAGEGVRAGIGAGLRFVFRHPLLRAVTLASAVSNFCGTVGAAVLMVLLAGELGLSPLWCGLVFTAEAVGGLLGGLLTARLADRFGTGRTMCASVLLSGLAWLAAVPAFRDDWRFAVAVALQGLGWAAFMPFKIGAVTLRQRLCPPGMLGRVTATVRFVVWGAMPLGALAGGLLGEWFGARTALWTGAGAELLAVLPLLPLWASRPDRAGQDAVPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZD7</accession>
    <name>A0A0F4IZD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000843">
        <property type="protein sequence ID" value="KJY27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27377">
        <property type="protein sequence ID" value="KJY27377"/>
        <property type="gene ID" value="VR44_27750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1788"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16549" checksum="B735F4DF97B2475A" modified="2015-06-24" version="1">MITFTGPQGASAQDQARRGWDHFGFGVPWEESYGYSQGIRAGDTVYISGQVSHDEAGNFVGAGDFELQVRTAFANLDKVLAHYRVPRSQIISMKIFTKDLRQNFDTAARLHKEYVGNHRTTDTIVGVSDMSVPEQLVEIEAIVQVSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZT6</accession>
    <name>A0A0F4IZT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo alpha-1,4 polygalactosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000863">
        <property type="protein sequence ID" value="KJY27169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950447.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000863.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27169">
        <property type="protein sequence ID" value="KJY27169"/>
        <property type="gene ID" value="VR44_28295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1903"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470434" evidence="2">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="3">
        <location>
            <begin position="52"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="30504" checksum="0A1CEED8C264D021" modified="2015-06-24" version="1">MKRFTAVAVTALLLLTAACTADPDDGDDGQTPPPQPSASPGGRWQPRPGTAWQWQLTGQLDTSVKVPVYDIDGFNTTKEQVAALRSAGRRTICYVSTGAWEDFRPDADAFPKSLLGEGNGWKGERWLDIRQTSALEPLMAKRFDMCRDKGFDAVEPDNMDGYKNKTGFPLTSAHQLTYNRLIARLAHDRGLAVGLKNDLDQIPDLVGDFDFAVNEQCAQYEECDSLTPFIKADKAVFHVEYERSTNEFCARSKELRLSSMEKKYDLGPWRKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J029</accession>
    <name>A0A0F4J029_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="11" type="ORF">VR44_30420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000959">
        <property type="protein sequence ID" value="KJY26281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950838.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000959.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5342"/>
    <dbReference type="EnsemblBacteria" id="KJY26281">
        <property type="protein sequence ID" value="KJY26281"/>
        <property type="gene ID" value="VR44_30420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2497"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="257"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY26281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="676" mass="75052" checksum="D80C329E492BA05D" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J073</accession>
    <name>A0A0F4J073_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_27110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000809">
        <property type="protein sequence ID" value="KJY27662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950238.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000809.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27662">
        <property type="protein sequence ID" value="KJY27662"/>
        <property type="gene ID" value="VR44_27110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1607"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY27662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="36239" checksum="38DB532889D81866" modified="2015-06-24" version="1">MDHSGHGMDMNMDMDMNMDLPPFTLGRGLEFSFDAFFLFGSLLALALYGWGVVRLRRRGDDWPLGRTVAFVTGVLTVLLVMCTKLNDYGMVMFSVHMIQHMVISMVTPILVLLGAPVTLALRALPPAARGSKGPRELLLMLLHSRYMRIITHPAFTIPMFIASLYALYFTPLFDFLMQSRAGHIGMMVHFLAVGLIFFWPIMGVDPGPHRPGYVMRMLELFAGMPFHAFFGIALMMASEPMIKTYANPPASLGIDPLDDQHWGGGIAWAFSEIPSVLVLIALVYQWYHSEQRAAKRSDRAADRDGDKELEAYNAYLASLQGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J091</accession>
    <name>A0A0F4J091_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000866">
        <property type="protein sequence ID" value="KJY27143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950459.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000866.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27143">
        <property type="protein sequence ID" value="KJY27143"/>
        <property type="gene ID" value="VR44_28360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1996"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23395" checksum="9C60DE22BD0F91A3" modified="2015-06-24" version="1">MDGELFPRGRTEVAPGAVHLPDWLGPRRQRELLDACRAWARPPAGLRTVRTPGGGTMTARQVCLGLHWYPYAYAPTAVDGDGAPVKPMPPWLAELGRRAVTDAYGEPPPVADAYDIALVNFYGADSRMGMHRDAEERSPAPVVSLSLGDACVFRFGNTASRGRPYRDVELRSGDLFVFGGPSRLAYHGVPRVLPGTAPPALGLTGRLNITLRVGGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0D8</accession>
    <name>A0A0F4J0D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000844">
        <property type="protein sequence ID" value="KJY27359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27359">
        <property type="protein sequence ID" value="KJY27359"/>
        <property type="gene ID" value="VR44_27800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1798"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="7803" checksum="CEA536BD354F36F3" modified="2015-06-24" version="1" fragment="single">IDFFESRGLPFVVGANCFHGEQPYTAEEIAAALHLRDPATPVLLLDARSRASARDCLLALLDLVIARAGAPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0E8</accession>
    <name>A0A0F4J0E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Citrate:proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_26885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000801">
        <property type="protein sequence ID" value="KJY27745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950196.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000801.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27745">
        <property type="protein sequence ID" value="KJY27745"/>
        <property type="gene ID" value="VR44_26885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1536"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014738">
        <property type="entry name" value="Citrate_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00784">
        <property type="entry name" value="citMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="476" mass="49203" checksum="D237978024C846AB" modified="2015-06-24" version="1">MLTFLGFAMIATFLVLIMMKKMSPIAALVLIPALFCVFAGKGAHLGDYVIDGVGKLAPTAAMLMFAIVYFGVMIDVGLFDPVVRGILRFCKADPMRVVVGTAVLAAVVSLDGDGSTTFMITVSAMYPLYKRLGLSLVVMTGVAATANGVMNTLPWGGPTARAATALKLDASDIFVPMIPALAAGLVFVLVLAYVLGVRERRRVGSLVMPGEEAAREPESLVAAGSGAKAAAGGAGAATGGGSGAGPDAEPEPAPEGPAPAPEDMQGLDPHRPTLRPRLYWFNAGLTAALLTAMIMELLPIPVLFLLGAALALTVNFPHMPDQKARIAAHADNVLNVAGMVFAAAVFTGVLSGTGMVKHMADWLVGAIPDGMGPHMALVTGLLSLPLTYFMSNDGFYFGVLPVLAEAGAAHGVPPLEIARASLVGQALHMSSPLVPAVYVLVGMARVEFGDHTRFTVKWAALTSLVVLGAGMLFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0I0</accession>
    <name>A0A0F4J0I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_26770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000798">
        <property type="protein sequence ID" value="KJY27780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27780">
        <property type="protein sequence ID" value="KJY27780"/>
        <property type="gene ID" value="VR44_26770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1512"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017340-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="20142" checksum="4A98AFBFEB443CF1" modified="2015-06-24" version="1">MSAADEVLDVVDRDDRVTGQAPRGEVYSRGLLHRCVFVQVRDGLGRIFVHRRTASKLVFPAHYDMFVGGVLGAGEDYPGAALREAEEELGVSGLEQPVPLFKFLYEGPGGAWWSYVHEVRCALPVAPQESEVDWHTWLEPEELERRVAGGEWAWVPDGLEAYRRLRAFREGGSRPPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0V0</accession>
    <name>A0A0F4J0V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000929">
        <property type="protein sequence ID" value="KJY26531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26531">
        <property type="protein sequence ID" value="KJY26531"/>
        <property type="gene ID" value="VR44_29835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2348"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="234" mass="24029" checksum="8105D58673716A41" modified="2015-06-24" version="1">MEELNQLGGAAPRIGDLPTGSGAVVWSLDTTLGVIGGHAADGAEALLDEGERKRAARLVRPGDRRTYLASHLGLRVLLGGYLGTAPEEVRLVREDCPNCGGPHGRPAVAGGGVHFSLSHSHGLAYFAFAAVPVGVDVEGLPSSKAVADILSSLHPAEAAEITALPEDGRRVALARVWSRKEAYLKATGTGLAYGVAVAEPFVGSGPAPGRVPGWTLRDLPAPPEFAAALAVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0W8</accession>
    <name>A0A0F4J0W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000825">
        <property type="protein sequence ID" value="KJY27524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27524">
        <property type="protein sequence ID" value="KJY27524"/>
        <property type="gene ID" value="VR44_27330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21913" checksum="6CAA018F98514C30" modified="2015-06-24" version="1" fragment="single">MSRHALGHPVVLVPVRFDGPVAVVGPVLAPGAAACLCCTEYRRLATAGGRVPWRSPGLALAGVPSPALSAALGALVRDLLDGEEPGREDGAAVVHVVHQGRGTWSTHRLRPLGGCAVCHPLPADSASVPDPLPAAPRPLPDPRVLRAPNPRTAGPELLRRELHDERFGPVRRLFRSEDSAFSLTSAFVTDGRLVDDGGYGRAGDFATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0Z4</accession>
    <name>A0A0F4J0Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_26410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000783">
        <property type="protein sequence ID" value="KJY27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950105.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000783.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27932">
        <property type="protein sequence ID" value="KJY27932"/>
        <property type="gene ID" value="VR44_26410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1466"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="22970" checksum="969BF45E97253355" modified="2015-06-24" version="1" fragment="single">ELHLPAGTTASAVATAELPLPAEAKGNPEGYLFPATYPVTSKTTPAALLGTMVRTANQKLATKAVADGGRAYGMTPYQTATLASIIEAEADNPADMGKVARVVHNRLAKSMPLQMDSTLNYALNRNTVDTKLKDTRIDHPFNTYEHRGLPPAPIDSPGLQAMAAAVAPTPGDWLFFVTVKPGDTRFSAGYEEHRKHVAEFNRLRAAAPAAPAVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2T9</accession>
    <name>A0A0F4J2T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000722">
        <property type="protein sequence ID" value="KJY28530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949866.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000722.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28530">
        <property type="protein sequence ID" value="KJY28530"/>
        <property type="gene ID" value="VR44_25140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1120"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="13556" checksum="4D32D290469ECFD3" modified="2015-06-24" version="1">MRGITFPAWHGEHYVTLAEVLVRLGSSGLDLTWRIECDEIVDPRCVEMERRSADAGMDMLTLLSLTTPFLQLINAEARGFAGDELVLVLTEFDSSSWDVMAVDERVLSELRQHYPDAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2W2</accession>
    <name>A0A0F4J2W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949811.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28672">
        <property type="protein sequence ID" value="KJY28672"/>
        <property type="gene ID" value="VR44_24860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.971"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470071" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="23510" checksum="F18869A0378679AE" modified="2015-06-24" version="1">MLVAAAVCPAPPLLVPEVAAGAAAELDEARTACSDALAVLAASRPDVLVVVGSADAEHQGPYPQGSRGGFHGYGVDAEVRLGEGEEGPRPLPASLAVGAWLLGRARWGAAPVEGLAVAASLETGRCLETGRELAAADERVALLVMGDGSACRTLKAPGYLDERAAAFDAAAGRALGSADTDALAALDPVLAAELQAAGRAPWQVLAGAAEGAGLGGRLLYEDAPYGVGYFVAAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3N4</accession>
    <name>A0A0F4J3N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_24240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000695">
        <property type="protein sequence ID" value="KJY28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28895">
        <property type="protein sequence ID" value="KJY28895"/>
        <property type="gene ID" value="VR44_24240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.828"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="357"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="512"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="659"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="959" mass="101795" checksum="A5265D3922FA6C77" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Q1</accession>
    <name>A0A0F4J3Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000822">
        <property type="protein sequence ID" value="KJY27546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27546">
        <property type="protein sequence ID" value="KJY27546"/>
        <property type="gene ID" value="VR44_27305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11252" checksum="6C40C6AFC7275B8C" modified="2015-06-24" version="1">MAGGPVPAEAAARWRAALDLPEQVFLHPVAAAPGGHAAEDLLTRLGRPKPHLVDLGNALHLRCLPKWLSRHGGGAVLEEALPAPGGLDAPARAVELVLEVYRTGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J426</accession>
    <name>A0A0F4J426_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000675">
        <property type="protein sequence ID" value="KJY29107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949599.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000675.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29107">
        <property type="protein sequence ID" value="KJY29107"/>
        <property type="gene ID" value="VR44_23690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.684"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="886" mass="94438" checksum="733D1A1E1DB817B7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4E0</accession>
    <name>A0A0F4J4E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000663">
        <property type="protein sequence ID" value="KJY29217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949565.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000663.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29217">
        <property type="protein sequence ID" value="KJY29217"/>
        <property type="gene ID" value="VR44_23505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.643"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="84"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="28356" checksum="8D9FE8E80363413C" modified="2015-06-24" version="1">MSSRNSQQNKAAAREKLRVEREKQAKKDKARRQVFVAGGVVAALALAGGIGYAVVQSSQPGYWEKAAEAPLVKPKNTEGADGLTVVIGKPEAKKTLELYEDSRCPACAAFEQTVGEQVRKDVDSGKFKLRYIGATFIDNGAKGEGSKNALSALGAALNVSPEAFLDYKAALYSKALHPDERVDSFAKDDYLLKVADTVPALKGNAEFKKAVEDGTYDRWAMDMSKSFDKSGVTGTPTLKMDGKKIDTPATPEAFTAAIDKAIAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4F0</accession>
    <name>A0A0F4J4F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ileS</name>
        <name evidence="11" type="ORF">VR44_23455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000662">
        <property type="protein sequence ID" value="KJY29227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949559.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000662.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5193"/>
    <dbReference type="EnsemblBacteria" id="KJY29227">
        <property type="protein sequence ID" value="KJY29227"/>
        <property type="gene ID" value="VR44_23455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.633"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="688"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="601"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY29227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116614" checksum="5DCE0A1E36ACC02E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5H4</accession>
    <name>A0A0F4J5H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inter-alpha-trypsin inhibitor heavy chain H5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000755">
        <property type="protein sequence ID" value="KJY28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950018.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000755.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28176">
        <property type="protein sequence ID" value="KJY28176"/>
        <property type="gene ID" value="VR44_25950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1290"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470751" evidence="2">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="39"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="423" mass="44494" checksum="C45C29C393579610" modified="2015-06-24" version="1">MITRKRLAAGACGLFVALTAGLFPQTAAAADGPAKEPPKVELVLDVSGSMRANDIDGQSRMAAAKQAFNEVLDAVPDEVRLGIRTLGATYPGEDRALGCKDTKQLYLYPVGTVNRTEAKTAVATLAPTGWTPIGPALQAAAQDLDGGNATRRIVLITDGEDTCAPLDPCEVARDIAAKGIHLVVDTLGLVPDAKTRSQLTCIAEATGGTYTSVAHTAELSGRVRQLVTRAADPVATPVAAEGAKSCENAPALKAGLYSDRETFGEHRWYKVDVRPGQELRASVSIGADRAVNNDYGILLRATTVHGREIVRGSEAGDGRTDVISTGLRYPKAEADGDEADKPETVCLQVSNSFSAGPAVKTAPGMPVELTVDLVDGPDDGSDVASFGLGRGWWLIGLLVLTGLLAGLVWGWISRWRISVWRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5Y6</accession>
    <name>A0A0F4J5Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000666">
        <property type="protein sequence ID" value="KJY29178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949575.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000666.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29178">
        <property type="protein sequence ID" value="KJY29178"/>
        <property type="gene ID" value="VR44_23570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="29620" checksum="B87960EF8ADF1554" modified="2015-06-24" version="1">MIVVTGATGNVGRPLTQALAKAGAEVTAVSRHAAPVPVPVPARVRHVSADLAEPRGLAAVLEGAQALFLLLSGELHAPESRVADVIGLAAAGGVRRVVLLSSQGVATRPLGPSRIAMRAVEDALRESGLEWAVLRPGGFASNALAWAESIRTRRTVAAPFGDVGVPVVDPVDIAEVAAACLLDGRHSGGVFELTGPEVITPRRQAEVIAASLGVPVRFHELTREEAKAEMTRFVPPELADDTLDIISAPNAAELRISPDVERVLGRGPRPFDSWVARNVAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6A5</accession>
    <name>A0A0F4J6A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000607">
        <property type="protein sequence ID" value="KJY29897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29897">
        <property type="protein sequence ID" value="KJY29897"/>
        <property type="gene ID" value="VR44_21755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="193" mass="20358" checksum="FDA17FCEC0377693" modified="2015-06-24" version="1" fragment="single">MAFSAAELHVLRRSLAHALQSSTAPLTAAEVQDCLRLAASVDEAVQEAGRLRAFLLDDLARYRGALPGSLSGYLELLQDALAAGYEPDPDDLSALRALRANPVAAAVLERAQGVAERSVRRRLAAAAPAPRTRLLALAGGREEPGPAAPGPEGPRPERPRPEPSPKEPPRPGRPVPTPGEVFPPRRKPAPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6L1</accession>
    <name>A0A0F4J6L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29850">
        <property type="protein sequence ID" value="KJY29850"/>
        <property type="gene ID" value="VR44_21805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.240"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13600" checksum="C716F729961CBA74" modified="2015-06-24" version="1">MDPAHSSATFGVMVKNVGKTQVVARALVQTAGLGGSPECPQGRYSPGTLRIDPGRIWFSDLGRCSVGRLENKDFQTLGAAIEDPDGTGDVQQGGAVYSAHVWVGDGQVKCKIGELWTTSCASFAYPPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6P3</accession>
    <name>A0A0F4J6P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000643">
        <property type="protein sequence ID" value="KJY29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949468.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000643.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29423">
        <property type="protein sequence ID" value="KJY29423"/>
        <property type="gene ID" value="VR44_22955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.528"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="38614" checksum="368A5F5111B859BA" modified="2015-06-24" version="1">MTTPSTARIEDLLQTGVREEVYPGAVWAVGDADGIRASGAVGLLDPDRPDEPMRLDTVFDMASLTKILAVWSTIGTLVEQGKLDLHAPLGSFWNEVAGHPLARATAHHLLTHTAGLPLRANLKNLYGTDPQDIRDGVLLEALHRPPGEAVEYTDRAALILGYLAEHLSGQPLDRLATDRVWHPLGMTRTRFGPLPGTEAARCAPTEYDEVIGTHLKGTAHDFSARLLGGVCGIAGTFSVLDDLALFLRHMLAHNRAAFGPTWIKDSLRIHTGTLTPARGLFWHPAPGTDPAEDIWVHYGFTGTGMWISTTQSRWAVLLTNKLRFNRDREPLTEIRNAFRTAGFTSPHRTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Q1</accession>
    <name>A0A0F4J6Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000638">
        <property type="protein sequence ID" value="KJY29499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29499">
        <property type="protein sequence ID" value="KJY29499"/>
        <property type="gene ID" value="VR44_22785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.489"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="13293" checksum="49D38C9732CDA4AA" modified="2015-06-24" version="1">MRDQGQHVGPGVREQLVRPAVHAHGAAAGVVAAPGQEVEHLHQPTPVELREQAEEVLDGTGEERGARAPAELVLQPAPRRLALPARHQPAQQTGHLLPACRHPFQHAPGHGPGPPFVHTADPSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W9</accession>
    <name>A0A0F4J6W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_24830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949815.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28676">
        <property type="protein sequence ID" value="KJY28676"/>
        <property type="gene ID" value="VR44_24830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="90"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="431"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="491" mass="53679" checksum="0DB90D5D20ECAA6C" modified="2015-06-24" version="1" fragment="single">MSAEATNPEAHAEVRPELRRRGRTRLDLRRLGRAALLGPASRDRLPDAIGHVAEAHRAHHPDADLSILRRAYLLAESSHRGQMRKSGEPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTDVTLDQVRAEFGDEVAFIVDGVTKVEKIDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILHPEEYEHTRALIASHAGADDPLLAIAESVRTVLREAGITAEVLVRPRHFVSVHRISRTRGELRGPDFGRILVLVGENADCYAVLGELHTCFTPVVSEFKDFIAVPKFNLYQSLHTAVAVPEGYVAEVIVRTRQMHRVAEAGVVALGNPYATGEGADCEEERVDPTRPGWLSRLLDWQQSAPDPDTFWTGLRAELAQDREITVYRADGGTLALPAGASCIDAAYAQHGEAAHGCIGARVNGRLTSLSAPLSDGDTVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7H1</accession>
    <name>A0A0F4J7H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000571">
        <property type="protein sequence ID" value="KJY30342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949043.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000571.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30342">
        <property type="protein sequence ID" value="KJY30342"/>
        <property type="gene ID" value="VR44_20690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8853"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470455" evidence="1">
        <location>
            <begin position="37"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="492"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="553" mass="58827" checksum="10C7271A75D82F51" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8E0</accession>
    <name>A0A0F4J8E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000594">
        <property type="protein sequence ID" value="KJY30054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30054">
        <property type="protein sequence ID" value="KJY30054"/>
        <property type="gene ID" value="VR44_21365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.146"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="85" mass="8354" checksum="473276538C73F533" modified="2015-06-24" version="1" fragment="single">VAEEIVRFLTAAAPPVLLTPALAPDRVPLTLAPHTLLVALPAPGTSAPAAAGTAGPCSYAVLARADADRLDGLARDLAACAADTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9X1</accession>
    <name>A0A0F4J9X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsA</name>
        <name evidence="4" type="ORF">VR44_20200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000557">
        <property type="protein sequence ID" value="KJY30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042812805.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000557.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5306"/>
    <dbReference type="EnsemblBacteria" id="KJY30543">
        <property type="protein sequence ID" value="KJY30543"/>
        <property type="gene ID" value="VR44_20200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8745"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="504" mass="55304" checksum="D84DEB3475C9BDCB" modified="2015-06-24" version="1">MTSSTETTATTTPQVAVNDIGNAEAFLAAIDETIKYFNDGDIVDGVIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPNEVVKVGDEIEALVLQKEDKEGRLILSKKRAQYERAWGTIEKIKEEDGIVTGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRQTFLTTLQKGQVRSGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMDRERVSLSLKATQEDPWQQFARTHQIGQVVPGKVTKLVPFGAFVRVDEGIEGLVHISELAERHVEIPEQVVQVNDEIFVKVIDIDLERRRISLSLKQANESFGADPASVEFDPTLYGMAASYDDQGNYIYPEGFDPETNDWLEGYETQRETWERQYAEAQVRFEQHQAQVIKSREADEAAAAAGETAPAAGGNAGAGISGGSYSSEGADETSGALASDEALAALREKLAGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9Y6</accession>
    <name>A0A0F4J9Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_22050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29791">
        <property type="protein sequence ID" value="KJY29791"/>
        <property type="gene ID" value="VR44_22050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.290"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="518" mass="55795" checksum="83D6D9A457AE740E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA39</accession>
    <name>A0A0F4JA39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_19905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000548">
        <property type="protein sequence ID" value="KJY30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948899.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000548.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3097"/>
    <dbReference type="EnsemblBacteria" id="KJY30669">
        <property type="protein sequence ID" value="KJY30669"/>
        <property type="gene ID" value="VR44_19905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8601"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11543" checksum="5BDA4F329FC8A719" modified="2015-06-24" version="1">MHIRGDHAELTVGGRLDVRSAADARTALHTALDDGHGDLVLDLTGLDSWDATGLGVIMGAHRRAGRTGRRLVLRGVPDRMQRLLVATRLHRILAIEGGLEAESLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA61</accession>
    <name>A0A0F4JA61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Citrate synthase 2</fullName>
            <ecNumber evidence="1">2.3.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000505">
        <property type="protein sequence ID" value="KJY31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31257">
        <property type="protein sequence ID" value="KJY31257"/>
        <property type="gene ID" value="VR44_18490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="188" mass="20195" checksum="02040F723E1E6F72" modified="2015-06-24" version="1" fragment="single">MSDFVPGLEGVVAFETEIAEPDKEGGSLRYRGVDIEDLVGHVSFGNVWGLLVDGAFNPGLPAAEPFPIPVHSGDIRVDVQSALAMLAPVWGLKPLLDIDVQTARDDLARAAVMALSYVAQSARGQGLPMVPQREIDKAESVVERFMIRWRGEPDPKHVKAVDAYWTSAAEHGMNASTFTARVIASTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAR2</accession>
    <name>A0A0F4JAR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">VR44_18135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000494">
        <property type="protein sequence ID" value="KJY31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948565.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene923"/>
    <dbReference type="EnsemblBacteria" id="KJY31432">
        <property type="protein sequence ID" value="KJY31432"/>
        <property type="gene ID" value="VR44_18135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8174"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="25308" checksum="0EF239968AA957E9" modified="2015-06-24" version="1">MTRASLDKQPHEVASMFDGVAEKYDLTNDVLSLGQARLWRKEAAKAVAARPGQKVLDLAAGTATSSLPYAATGAYVVPCDFSLGMLREGKKRNPWLPLTAGDATRLPFKDDVFDTVTISFGLRNVQDTDAALRELYRVTKPGGQVVISEFSQPTWAPFRTVYTEYLMRALPPVARAVSSNPDAYVYLAESIREWPDQPALAELLQKAGWGKVAWRNLSGGIVALHRGVKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCC9</accession>
    <name>A0A0F4JCC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000459">
        <property type="protein sequence ID" value="KJY31870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948403.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000459.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000054_gene376"/>
    <dbReference type="EnsemblBacteria" id="KJY31870">
        <property type="protein sequence ID" value="KJY31870"/>
        <property type="gene ID" value="VR44_17255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7985"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="15925" checksum="4B8F07312321BCEE" modified="2015-06-24" version="1">MRISARADYAVRAALQLAAAQDEGPLKAEAIAEAQDIPHKFLEGILNDMRRGGLVLSRRGGNGGYRLARPAASISIADVIRVVDGPLVSVRGVRPPDLSYSGPAESLLPLWIALRANVREILDGVSLADVASCDLPAGVSALAHTPGAWTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDJ4</accession>
    <name>A0A0F4JDJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000422">
        <property type="protein sequence ID" value="KJY32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948214.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000422.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32280">
        <property type="protein sequence ID" value="KJY32280"/>
        <property type="gene ID" value="VR44_16250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7673"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="20918" checksum="A60B4C88EE3BCC17" modified="2015-06-24" version="1">MTENAIEIAPDSALIVIDVQKGFDDASFWGPRNNPAAEENIAALMDAWQESGRPVVLVQHASPRPGSVLAADQPGYAFKDFVADRVGREALHVTKTVNSSFYGTPDLGDWLTARGIRQLVVVGIQTNMCVETTARMGGNLGYEVIVPLDATHTFDLTGPGGLSLTADQLATATAVSLHGGRFAHVTTTSEVLTAAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDK3</accession>
    <name>A0A0F4JDK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948414.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31833">
        <property type="protein sequence ID" value="KJY31833"/>
        <property type="gene ID" value="VR44_17320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7999"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="18379" checksum="A482E450295C50EF" modified="2015-06-24" version="1">MSHEDVNPGAAPTLDQARKQIARYGLEADPQAVLVAVRLMAAGARLDRASEVHFARSGLSTGRYRLLVDLEDGDGEKSPSQLAKSLGVSRATVTGLVAGLEREGLVARRASTEDGRGAVVVLTARGSRRLHDMAADHFARLEALVGGLAADERGLFLDLLERITQRIGALTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDR9</accession>
    <name>A0A0F4JDR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000456">
        <property type="protein sequence ID" value="KJY31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31908">
        <property type="protein sequence ID" value="KJY31908"/>
        <property type="gene ID" value="VR44_17185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7970"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="23634" checksum="006C7D4A074C5747" modified="2015-06-24" version="1">MKLRLTVHEARHGAGTFSVVRPARPPEHAALFDDSWWLNAYADRDAALLLAGLWTLAAGSPRSLVHVPLRGPAPPAGSGRLDLVLLHHSLQLAPSRWKELRGRLSPGRPRTVDVSLAEPAGEDYASLHHTEHRDRFHQSIHAETLFMTGSAKAFRLGAAAFLDVAREGPAYVDPYPDRAYGHRHYCATVPCDARRRDIHVEYREPPAPDGPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDX3</accession>
    <name>A0A0F4JDX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948669.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000511.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31186">
        <property type="protein sequence ID" value="KJY31186"/>
        <property type="gene ID" value="VR44_18680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8345"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470858" evidence="2">
        <location>
            <begin position="38"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="89"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="328" mass="35882" checksum="8750CF16A1316EF6" modified="2015-06-24" version="1">MRTRPSTPGQVHRRPGRRSPRALLSAVSALATGAVLAARHAHELYHPPAAHPGRTPRHKGLPVRPLSVTTTRDRVTLDAWVVPGRGPHTVVICHGMGRTKSSVLGHIALLHEAGHHVVAYDMRNHGESGRDRKYGSMSERYTGDLADVIASVRRDPEVGAGELALIGFSFSTWVSLHVLRRVGTPVAAVVCDSGPMSDTAAGLREFAGLRRSQLPAPVRTGAAYALYRHLFSRISMHMLAVRNWPPDLAGLPTRLMFIAGAQDPVIDEAQIMGVADRYPEAERWTAPQAMHMNALRFDAAEYRERVLGFLEASFEAAADRRKEAVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE99</accession>
    <name>A0A0F4JE99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gabD2</name>
        <name evidence="6" type="ORF">VR44_16730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000443">
        <property type="protein sequence ID" value="KJY32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948305.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000443.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1099"/>
    <dbReference type="EnsemblBacteria" id="KJY32073">
        <property type="protein sequence ID" value="KJY32073"/>
        <property type="gene ID" value="VR44_16730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7781"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="53"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="543" mass="57416" checksum="633E7ED05DF4B977" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF70</accession>
    <name>A0A0F4JF70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000388">
        <property type="protein sequence ID" value="KJY32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948008.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000388.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32855">
        <property type="protein sequence ID" value="KJY32855"/>
        <property type="gene ID" value="VR44_15150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7448"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="7397" checksum="88400928E89366E2" modified="2015-06-24" version="1">MNEHENHRKRHSEATPPSKAPGESGDREAREQAEEAVMPGGKDGEAGDALTPNTDAQRRTARDDHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFA9</accession>
    <name>A0A0F4JFA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_14980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947972.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32900">
        <property type="protein sequence ID" value="KJY32900"/>
        <property type="gene ID" value="VR44_14980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7412"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="34136" checksum="C16F8D2332762FCB" modified="2015-06-24" version="1">MDVLSEVITVARTGRPRSAYVRWHAPWRQEFASVPGSAGFQVILEGSCWLLSPHAAPLPLGPGDVLFLPHGTGHTLADDPATAVTAPACTPDDPELPGPFMSDSVDRLGQGGPATVVLCGAYQLDPSRTHPLLLTLPDVIHLPADRNRHPELHAAVQLLASEVGNPRLGATAIVPALLDTLLMYVLRIWLAEQPAHGSTTGWAAALNDPAVTAALHAVHRDPTAPWTVAKLAAEAGLSRAAFARRFTSMIGQPPLGYLTWWRMTTAARLLQTTEAPLRSIAAQVGYTSEFAFANAFKRRHGLAPGAYRRRELNRLQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFW5</accession>
    <name>A0A0F4JFW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948073.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32648">
        <property type="protein sequence ID" value="KJY32648"/>
        <property type="gene ID" value="VR44_15525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7505"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="10600" checksum="7FAA20122D484947" modified="2015-06-24" version="1">MATKKVTITLPDEVLEYIKATVDDRGVSAYVTAAVEHRVAMDKLRKLSDLLDEEYGPLTDEELRAADARLDAMDAWHEGRQEEAEEVDPLAGKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFW6</accession>
    <name>A0A0F4JFW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32694">
        <property type="protein sequence ID" value="KJY32694"/>
        <property type="gene ID" value="VR44_15470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7495"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15258" checksum="554974A75243CC83" modified="2015-06-24" version="1" fragment="single">MTDTGQVPGEGHPDNAGMVDQQGVPAPVPQMPPLPPMPPAGYAFQDLVDDPAEDEELLLMPSGHGQGGAWSDPQVVPQVPAFPGEFPADQGYTEYPQPEYSQPQAAGYPEPGQLGFPEPGYAVPGQQPVPGQPMPGQPLAGQPLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFY4</accession>
    <name>A0A0F4JFY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000457">
        <property type="protein sequence ID" value="KJY31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31891">
        <property type="protein sequence ID" value="KJY31891"/>
        <property type="gene ID" value="VR44_17240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7981"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="12786" checksum="5A639EAF966EE03C" modified="2015-06-24" version="1">MSQKFLKEHADVVEAVLRGTVKTNEWIHSNQDKAKASANARLLADTGKGLDPKVIDPAWPSISVTDDPLAATLKTQSEWAVKAKLLEKPDLAGIYDLTLLNKVLKAAGKPAVSDAGLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG44</accession>
    <name>A0A0F4JG44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947874.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3324"/>
    <dbReference type="EnsemblBacteria" id="KJY33175">
        <property type="protein sequence ID" value="KJY33175"/>
        <property type="gene ID" value="VR44_14400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7229"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="387" mass="41258" checksum="9E47C4D7FF3C07B3" modified="2015-06-24" version="1">MKIGIVCPYSWDVPGGVQFHIRDLAEHLIRLGHEVSVLAPADDETPLPPYVVSAGRAVPVPYNGSVARLNFGFLSAARVRRWLHDGVFDVIHIHEPASPSLGLLSCWAAQGPIVATFHTSNPRSRAMIAAYPILQPALEKISARIAVSEYARRTLVEHLGGDAVVIPNGVDVDFFAKADPKPEWGGQTLGFIGRIDEPRKGLPVLMAAFPRIVAECPDVRLLVAGRGDEEEAVASLPAELRSRVEFLGMVSDEDKARLLRSVDVYVAPNTGGESFGIILVEALSAGAAVLASDLDAFAQVLDQGAAGELFANEDADSLAAAAVALLRDPARRAELSARGSAHVRRFDWSTVGADILAVYETVTAGAAAVAADERVPLRTRLGFSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGL4</accession>
    <name>A0A0F4JGL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GdmX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947981.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32908">
        <property type="protein sequence ID" value="KJY32908"/>
        <property type="gene ID" value="VR44_14950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7406"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="16286" checksum="B456DADA53B365A7" modified="2015-06-24" version="1">MLEDKEALRALMTRGWRALDRKDWAAWAACWAEDAVLEFGPWGTIRGRAAIRARVEEAEAPFPSMQHHLLNLDFDVAGDAATGIGYMWFVAVTTPERNSAPYSMGGPYDWEFRRDPDQGWLLIRQQLGVWWTNGDAPQEAFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGU5</accession>
    <name>A0A0F4JGU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33024">
        <property type="protein sequence ID" value="KJY33024"/>
        <property type="gene ID" value="VR44_14625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7252"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="29389" checksum="00D4D2F5C0EAC396" modified="2015-06-24" version="1" fragment="single">ETALTLVYVVWGSTYLGIRIVVQTMPPFLSAGARFLSAGLILAGVVAWRYGPSALRVTRAQLGSTLLVGLLLVLGGNGLVVLAETSVPSGLAALLVAAVPMWVVVLRAVTGDRPPARTLAGVLVGLCGMGVLTSPGLSGEVRLSGVLLVVAGSVTWALGSFSAGRLPLPGNPFTGSVYQMLWGGAAQVLVGLARGEQHGLDPASFSTASWLALGYLVLIGSVVGFTSYAWLLQAAPLSLVATYAYVNPVVAVALGALVLDEPLTLPIVLGGLIVVAAVGVIVSTERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGY9</accession>
    <name>A0A0F4JGY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VR44_14740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000377">
        <property type="protein sequence ID" value="KJY33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947934.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000377.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5603"/>
    <dbReference type="EnsemblBacteria" id="KJY33013">
        <property type="protein sequence ID" value="KJY33013"/>
        <property type="gene ID" value="VR44_14740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7276"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="47"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="330"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJY33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="554" mass="60237" checksum="4CAFB746C5B63967" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH47</accession>
    <name>A0A0F4JH47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3306"/>
    <dbReference type="EnsemblBacteria" id="KJY33129">
        <property type="protein sequence ID" value="KJY33129"/>
        <property type="gene ID" value="VR44_14505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11949" checksum="E7D3DADA5F7FFDE4" modified="2015-06-24" version="1" fragment="single">MTDSVILDVWCELQCPDCHSALDDVRALRARYGDRLDIRLRHFPLEKHKHAFAAAQAAEEALEQGQGWPYAEAVLARTAELGERGEAVLLDVARELGMDAEEFDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI28</accession>
    <name>A0A0F4JI28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000322">
        <property type="protein sequence ID" value="KJY33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947592.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000322.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33992">
        <property type="protein sequence ID" value="KJY33992"/>
        <property type="gene ID" value="VR44_12855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6654"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470507" evidence="2">
        <location>
            <begin position="31"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="22387" checksum="94F8EE69949D628C" modified="2015-06-24" version="1">MSDRKRSTALALASALAGSAVLLAAPAAHADVVDVEYKCQTPIGDKSAVSPIDIKAVKEGDGYKLTMSFQKGVSSSPIELGKGAMSPSAVITAGGAEQASIPVTGAPNAEAVPANTPIKISDLSGTYTPKKSGKVTFTAGVLTIKAMGTTTTCTPGNSPKPSLELDVTAAAGGGAPDGAPEGTLPQTGPADSALAFGTLGATVALSGAAGLLWLTRRGRRAQRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI65</accession>
    <name>A0A0F4JI65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000400">
        <property type="protein sequence ID" value="KJY32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948081.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000400.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32656">
        <property type="protein sequence ID" value="KJY32656"/>
        <property type="gene ID" value="VR44_15570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7514"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="35860" checksum="A293BE4259CB6893" modified="2015-06-24" version="1">MKYTQLGRTGLKVSRLVLGTMNFGPQTDEPTSHAIMDSALDAGVNFFDTANVYGWGENKGRTEEIIGTWFAQGGGRREKTVLATKVYGSMAPEGEPWPNYDRLSALNIRRAVDASLKRLQTDHIDVYQFHHVDRLTPFEEIWQAVDVLIQQGKILYAGSSNFPGWKIAQANESAARGGRLGLVSEQCLYNLAERRAEMEVIPAAQEYGLGVIPWSPLHGGLLGGAIRKQAAGGGTGRSSSGRTADALADATVRAQVQAYEDLLDKHGLEPGDAALAWLLTRPGVTGPIVGPRTPEQLESALRAVELELSQEVLAGLDEIFPGPGPAPEAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIZ8</accession>
    <name>A0A0F4JIZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947691.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33753">
        <property type="protein sequence ID" value="KJY33753"/>
        <property type="gene ID" value="VR44_13385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6913"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="405" mass="41355" checksum="F7FB1FA6E850F372" modified="2015-06-24" version="1">MPAATPGTPSLLRAMNDRAALELLLTHGPLSRTRIGQLTGLSKPTASQLLARLEAAGLVVATGTDGGRPGPNAQLYAVNGRAAHVGGLDVTPTGSSPDRVLAAVADLTGAVTGSFELPYTEGADAVGQVTGALAGALADAGLGLDDLHRVVIATPGAFDPRSGRLRYASHLPGWHSPTLLDELAAALPVPVEYENDVNLAAVAEQRLGAARGHEDFVLLWNEEGLGAALVLGGRLHRGWTGGAGEVGFLPVPGHPLVRQVTRANTGGYQELAGVQVLPALAAEAGVDTSGLPRDGQVPAAVALLRRAAAAPEGARLDFLRSYATALATGLASLVSVLDPEIVVLAGEAIAAGGDPLRGLLEAELGELAPSRPRLVPGEVRERPVLRGALESALAATREEVFDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ21</accession>
    <name>A0A0F4JJ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-5'-phosphate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_14905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000382">
        <property type="protein sequence ID" value="KJY32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947961.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000382.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32936">
        <property type="protein sequence ID" value="KJY32936"/>
        <property type="gene ID" value="VR44_14905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7397"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="457"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="755" mass="79826" checksum="AED287D599BE2AF5" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK77</accession>
    <name>A0A0F4JK77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947518.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000310.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34173">
        <property type="protein sequence ID" value="KJY34173"/>
        <property type="gene ID" value="VR44_12465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6553"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="12006" checksum="229F38820FA01E1F" modified="2015-06-24" version="1">MPRGSSPKRERQYEHIKESALDRGESEKRAEEIAARTVNKERARSGESKTASRSSTEDMSSSKRGGQRSHSGSQGPTKEQLYNEAKKRNIKGRSQMDKAELKEALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKC7</accession>
    <name>A0A0F4JKC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000301">
        <property type="protein sequence ID" value="KJY34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947478.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000301.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34274">
        <property type="protein sequence ID" value="KJY34274"/>
        <property type="gene ID" value="VR44_12225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6427"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6796" checksum="DD8DA21CCEDE5222" modified="2015-06-24" version="1">MSIVDKLKEMLGKNPDQAKQAVERGGDMVDERTGGKYSDKVDMAQEKANEFIDRDRPQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLH3</accession>
    <name>A0A0F4JLH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_10940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000246">
        <property type="protein sequence ID" value="KJY35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947236.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000013_gene449"/>
    <dbReference type="EnsemblBacteria" id="KJY35030">
        <property type="protein sequence ID" value="KJY35030"/>
        <property type="gene ID" value="VR44_10940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6071"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="6">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="415" mass="45062" checksum="B18F1AB202E47434" modified="2015-06-24" version="1" fragment="single">VALGADVRWASCNIFSTQDHAAAAIAVGPNGTPENPQGVPVFAWKGETLEEYWWCTEQALTWPNTPTGGPNMILDDGGDATLLVHKGVEFEKAGAAPDPSTADSEEYGHILTLLNRTLAESPQKWTQLASEIRGVTEETTTGVHRLYEMMAEGTLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGYQVATLDDVVEIADIFVTTTGNKDIIMASDMAKMKHQAIVGNIGHFDNEIDMAGLARIEGIVKDEVKPQVHTWTFPDGKVLIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPEEYPTDVYVLPKHLDEKVARLHLDALGVKLTTLRPEQAEYIGVKVEGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM16</accession>
    <name>A0A0F4JM16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947162.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000234.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35240">
        <property type="protein sequence ID" value="KJY35240"/>
        <property type="gene ID" value="VR44_10535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5850"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="67" mass="6848" checksum="497CA1D6102E001E" modified="2015-06-24" version="1">MGSALVLGGTVATAQAAEPAQPARATVGSVMVYSTPEACVAAGQATGKRFSCTYWDFAFGWGLQIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMC8</accession>
    <name>A0A0F4JMC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947076.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3224"/>
    <dbReference type="EnsemblBacteria" id="KJY35502">
        <property type="protein sequence ID" value="KJY35502"/>
        <property type="gene ID" value="VR44_10070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5613"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="149"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="318" mass="35169" checksum="CAB97823CE6C4DDB" modified="2015-06-24" version="1">MAIAKAERLMNLALCLLGTRRPLSKRELRGSIEAYLEAGNDDSFNRMFERDKDDLRELGLVIETVENLEGETGYLARRDSNRLPPVSLDAEEAAALGLAAKVWQQARLAGAASGALQKLRAGGMPEAGDPYEGQHSAIEPRIPVHEAAFEPLMLACRDRRPVVFDYRKSNAARPEQRQVEPWALECWRGHWYLAGYDRDRGAERVFRLSRITGKVRSRAGKYTAEVPDVVTVRETVAAWAGEGAQRSALIRLRAGSGYPLRAKATAVREGADGWDELEIPYGHGLDAWLVEFGPDVVVVEPADLRADVVDRLRAVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMZ2</accession>
    <name>A0A0F4JMZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000237">
        <property type="protein sequence ID" value="KJY35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947176.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000237.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35194">
        <property type="protein sequence ID" value="KJY35194"/>
        <property type="gene ID" value="VR44_10615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5867"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="15162" checksum="AD9149D84F552DCE" modified="2015-06-24" version="1">MTTENDTITCEKYLPHPPAAVWKALTDPELHARWWAAGDIRPVVGHRFTLDMGNNFGHQACEVTEVDTERLLAYRFAEGTLDTTITWTLHPQGAGTRLVLTHTGFDLGSPMGRQALAGMGKGWPHVLDNLDAALARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPB8</accession>
    <name>A0A0F4JPB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000206">
        <property type="protein sequence ID" value="KJY35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946960.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000206.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35689">
        <property type="protein sequence ID" value="KJY35689"/>
        <property type="gene ID" value="VR44_09455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5291"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="22165" checksum="6A7EB101EB526912" modified="2015-06-24" version="1">MMKQERAVRTRQALLESAATVFGRRGYAEATLNMISVGAGVSPGALHFHFENKAAVAQAVEAAGARTLRAVTREVYERRTSALQCMADSSQALAGLLLSDVVARAAFQLNREPAYPSSFALPREWHDYVYRLLVEAAEEGALLPGLNHRNVATTVVAATLGFEALGRDDPQWLAPRTLSGFWRVVMPCLAAPAVLRELESAGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPN4</accession>
    <name>A0A0F4JPN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_09130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000198">
        <property type="protein sequence ID" value="KJY35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946900.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5118"/>
    <dbReference type="EnsemblBacteria" id="KJY35804">
        <property type="protein sequence ID" value="KJY35804"/>
        <property type="gene ID" value="VR44_09130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5090"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="111" mass="11672" checksum="2562C64AD4931498" modified="2015-06-24" version="1" fragment="single">AGRRPAADLPPVEFLECATLPAVLKELDAGGIDVCVLDGEAVPAGGMGVCRQIKDEIFRCPPVLLLMGRPQDAWLATWSRADAAVTLPVDPVEFPEALAGLLRSRLAPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRY6</accession>
    <name>A0A0F4JRY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000204">
        <property type="protein sequence ID" value="KJY35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35716">
        <property type="protein sequence ID" value="KJY35716"/>
        <property type="gene ID" value="VR44_09410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5210"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="374" mass="39554" checksum="BE538B8209B7FE88" modified="2015-06-24" version="1">MGMTINGTVEAGWEPVREAFEAFVAAEPHSPEAQLAVRHHGRTVVDLWGGEDTDGGTLSGVFSITKGAAHLVVALLAQEGVLDLDRPVSEYWPEFKGDGKERLTVRQLVAHGSGLIAVDEFSYELIADDALVAAALARQKPHWEPGTAYGYHAFVIGALTGEVVRRVTGRSIQEVYEERVRAPYGLDLYMGLPAELEGRWKPVLEMLPTPAQLEALAAGGPLPERMRVAFNMHHGMDPVTYANHPRVKALGPASAGGVGTARGIAALYAAAISGLDGRPALLEPDMVAEVARLHTPGQDAVVPEADHFGLGFEKQHAVGPEAFGHCGAAGANGFADPVTGIAYGYTRRRFGFPGGIAPENGPLTAAVLQVARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS55</accession>
    <name>A0A0F4JS55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36588">
        <property type="protein sequence ID" value="KJY36588"/>
        <property type="gene ID" value="VR44_07710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4154"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18412" checksum="5F2B978FCB1A04FA" modified="2015-06-24" version="1">MSLFIPDFDDSVVVRAADAEEIHYGPDSTLRLLADSSTGGGFLSTMRVSLRAGSDGARPHHHGRSAEMFYVIDGTAQLLAGDKVVTAEAGDLVVVPPGQQHAFAAAPGESAEMLVVITPGVERFEYFRHLERIRFGKVPPESLLEVQDLYDTYFGTSTTWEDARTLRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSC1</accession>
    <name>A0A0F4JSC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042816094.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5783"/>
    <dbReference type="EnsemblBacteria" id="KJY37267">
        <property type="protein sequence ID" value="KJY37267"/>
        <property type="gene ID" value="VR44_06030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2542"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="14419" checksum="DF010D12A2A3B36E" modified="2015-06-24" version="1">MSQIAGEPGTQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAILLQQAVPGSVLSCVFRLIDDSLEVTVSAPTTDGRAPERDTFAWTVLSALAGKVEATVEDNRTVSISLYKQRGAGPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSD0</accession>
    <name>A0A0F4JSD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946333.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5794"/>
    <dbReference type="EnsemblBacteria" id="KJY37277">
        <property type="protein sequence ID" value="KJY37277"/>
        <property type="gene ID" value="VR44_06095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2555"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="310" mass="33689" checksum="CEFF9BD8BD02D40C" modified="2015-06-24" version="1">MELEVRHLRALCAIADAGSLHKAARQLGVSQPSLTTQLRRIERALEGELFLRERTGCRPTPFGRTVLGRARPLLAEMAALVAEARAAAHGPRLRIGSTASRALPGWLRRLHRRAPETETTLVVDVSANALLRMTAAGQLDVAFVHEVEGSPLRVPGGLELRVLMEREPQFVSMSLDHPAARSPVVELQDLAGDRWTVDPSVDGEWDGLRRVFARAGLTPQVLHADYHTAASLIVSGEAVAPCQPTSGPRDDMAIRPLLGDPLAVRLLLATRPGEHAEAYEDLRAAYREAALGTPPYRAWLSRQGSPLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JST4</accession>
    <name>A0A0F4JST4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000185">
        <property type="protein sequence ID" value="KJY36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946843.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000185.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36001">
        <property type="protein sequence ID" value="KJY36001"/>
        <property type="gene ID" value="VR44_08820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5010"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="17047" checksum="3DA10C98A938A644" modified="2015-06-24" version="1">MSAPSPTRIATALSPDHRSRLMELAREVNFAEGTRLFREGGHADRFWIVRSGTVTLDIHVPGRRAAVIEHLGAGQLVGCSWLFKPYTWRLGAEAMTPVRAYEFEAEPVRMLMDADPGFGSAVGHWVGQVLAHRLQAARVRLLDLYAPYGSGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT23</accession>
    <name>A0A0F4JT23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase VR44_05895</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_05895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000109">
        <property type="protein sequence ID" value="KJY37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946298.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000109.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37335">
        <property type="protein sequence ID" value="KJY37335"/>
        <property type="gene ID" value="VR44_05895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2221"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="44135" checksum="A6085DBB8BE28018" modified="2015-06-24" version="1">MVDIREVPEDDIARAQEHAYLVFHDRPEPEGRARHHALLSRCERLGAYDGDALVGFMAAHPFRLSVPGTELGCPGLTFVSVAPTHRRRGVLTALMDEQLRRAGAAGSPLVCLWASEAAIYGRFGYGPATQGLTVEIDSSRPLALRIDPDPRPLRLVDPADALAVIGPCHEAARHTRAGRPSRSPARWAEEWLCEQDEEDEELGPPRILALGNPGEPAEGYVLYRTKHESDDGAARAPGLVRVDELEARTPAVAAALWTYVASLDLTGTVRAWGRPADDPLLSFAADRDQVRITAQFPALWLRLVDVKEALTARSWAAPVELVLDLADPRLPANAGRFRLKAGPGGATYETARAAPDLTLDVRDLAACYLGGTRVTELVAAGLVAEHTPGAAAALDAALRTGLLPHTADEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTU8</accession>
    <name>A0A0F4JTU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_08120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000163">
        <property type="protein sequence ID" value="KJY36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946713.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000163.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36401">
        <property type="protein sequence ID" value="KJY36401"/>
        <property type="gene ID" value="VR44_08120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4451"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="23151" checksum="8F3216F0844ED8AF" modified="2015-06-24" version="1">MSASAQHSEVPPAPPARAPRPRASAKGEQTRARLVAAARTLLAGELSERFTTRNVAALSGVSHGMCHYHFQDRTDLILAVITDIHPEWITPLEEAVSGPGTFEERAARVVELLGRPEGAELSHLHSALHWHALNDARVREALEAEYRRWRACFVALFQVLADERGRGLDPRPLGLAVAAAVDGLAAMESMADGTGAVPGAGGEPVLRTLIRTLAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVT0</accession>
    <name>A0A0F4JVT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000071">
        <property type="protein sequence ID" value="KJY38275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042810367.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene769"/>
    <dbReference type="EnsemblBacteria" id="KJY38275">
        <property type="protein sequence ID" value="KJY38275"/>
        <property type="gene ID" value="VR44_03865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8677"/>
    <dbReference type="eggNOG" id="ENOG5033G9I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7581" checksum="487E1EB5C7336864" modified="2015-06-24" version="1">MAKALLGYVGGSDPRLLAEMRRLQQRVQDLESELGRIQSENDALTAAAAQHGDSLLGSMDLDVSQAEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWG4</accession>
    <name>A0A0F4JWG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000054">
        <property type="protein sequence ID" value="KJY38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945782.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38712">
        <property type="protein sequence ID" value="KJY38712"/>
        <property type="gene ID" value="VR44_03045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7341"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="27855" checksum="7D310901BAC1240B" modified="2015-06-24" version="1">MGFFDGFFDGIRGARAMRFDSGNASSNAIELTKRQPTVSLTKQQAVHGNLRVNLSWRMRTSDIGGPSGQSGQLFRHPFKLFKPDMVQAHTQGMVNVDLDMGCLYELTDGTRGAVQPLGNLLGDLNDPPYVKLSGDDRFGSPSGETLYVNLDHADEIKRLLVFVYIYDQTPAFDRTHALVTLYPTAGPRIEIPLEERHPQARSCAVVSLQNVKGELIVRREVKFVYGFQAELDRLYGWGLQWGRGYKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXI4</accession>
    <name>A0A0F4JXI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945845.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000022_gene6615"/>
    <dbReference type="EnsemblBacteria" id="KJY38534">
        <property type="protein sequence ID" value="KJY38534"/>
        <property type="gene ID" value="VR44_03375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7892"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="58"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="382" mass="40298" checksum="CC52F10339FEC08B" modified="2015-06-24" version="1">MSAVLLDAVRRRLAESGAEPTPARVAAALRAQGRLLGDAEVLGVAAELRSELVGAGPLERLLEDPGVTDVLVAAPDRVWVDRGGGLELTEVTFADAEAVRRLAQRLAAVAGRRLDDARPWVDARMPDGTRLHAVLPPVAVGSACLSLRVVRPKAFTLEELVAAGTLPPGGQRLLRAMVEARLSFLVSGGTGTGKTTLLSALLGLVGPAERIVLAEDSAELRPDHPHVVRLETRPANQEGAGLVTLADLVRQALRMRPDRLVVGEVRGAEVADLLAALNTGHEGGCGTVHANAAEHVPARLEALGTAAGLDRAALHSQLAAALTLVVHLARDRSGRRRVAEVHVLERDPAGLVVTVPALRWGARGFVRERGWERLGPLLRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY32</accession>
    <name>A0A0F4JY32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4913"/>
    <dbReference type="EnsemblBacteria" id="KJY38749">
        <property type="protein sequence ID" value="KJY38749"/>
        <property type="gene ID" value="VR44_03030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7338"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12121" checksum="CC3B9A44C034DC3A" modified="2015-06-24" version="1" fragment="single">MGVTLAKGGNVSLSKQAPNLTRVLIGLGWDARSTTGADFDLDASALLCRDGRVLGDQYFVFYNNLKSPEGSVEHTGDNLTGEGEGDDESIIVDLTKVPAQVDKIVFPVSIHEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K037</accession>
    <name>A0A0F4K037_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000025">
        <property type="protein sequence ID" value="KJY39298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945575.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39298">
        <property type="protein sequence ID" value="KJY39298"/>
        <property type="gene ID" value="VR44_01940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5792"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="688" mass="74524" checksum="447F8F44E7739FF1" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0T9</accession>
    <name>A0A0F4K0T9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="14" type="ORF">VR44_02705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000044">
        <property type="protein sequence ID" value="KJY38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945721.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38876">
        <property type="protein sequence ID" value="KJY38876"/>
        <property type="gene ID" value="VR44_02705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6847"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="410"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="880" mass="97681" checksum="EE11768778345FFC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2B9</accession>
    <name>A0A0F4K2B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945556.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39326">
        <property type="protein sequence ID" value="KJY39326"/>
        <property type="gene ID" value="VR44_01870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5778"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="237"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="326" mass="34129" checksum="001D6B6198EDDC27" modified="2015-06-24" version="1">MKTRPGKLGAVGLGWYVPERRIDNETISRWCDVTPEWITGRTGVEERRYAHDGEPTSAMAARALAMALEDAGLRGGDLAAVIVCTSTPDQPQPPTAAFVLAELGLRDIPAFDVNGVCAGFLYGLGAADGWRRRGPVALIGADKYSTILNPLDRRTVSLFGDGAGAVVLDALPAGAEGVGVVARCRPEHVNLVGVRGGGSRLPLRNAREPLADRFEMDGRGVVAWAESALPPVAAQACAEAGVTPADIDRFVFHQGSGRMVEFCAKWLDVPMDKVAVSADRFGNTGAASIPLTLAREAGAGRITRGDRVMIAGLGGGTAACATVVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2D3</accession>
    <name>A0A0F4K2D3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39341">
        <property type="protein sequence ID" value="KJY39341"/>
        <property type="gene ID" value="VR44_01900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5784"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="309" mass="31547" checksum="9DC76C5FB5A24A95" modified="2015-06-24" version="1">MPPAGLAPGAAWFDHRSQLGPRGYKYLPEACQYLLAAARAAVAGSDGLLERCPEERRGAVVGTNSAVAELHSVIDRTTRTEGADFVSPMTAPFFSVNLVGARLSTEHLLKGFNLTVTSPRVAGVEALHLAAHEVAGGRADAVLAGATEAPDPYAADALPETGAALLVLRPRASAAPGTTLLRSCLLFLPPRALTTAAGRERAQRTVVSALDAVTAGLAGADGTDVRLVTDGSPVARVVSDAVRGRRGPDVPPGADVPRAGSLEAVALLADGVSSGRGRARLVVTAAREGNVAIAMTTTEPLPGPPRQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2U1</accession>
    <name>A0A0F4K2U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000019">
        <property type="protein sequence ID" value="KJY39496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945486.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4177"/>
    <dbReference type="EnsemblBacteria" id="KJY39496">
        <property type="protein sequence ID" value="KJY39496"/>
        <property type="gene ID" value="VR44_01450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4722"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="29111" checksum="5B1D097C45B634FA" modified="2015-06-24" version="1">MSPFTGSTPATERWRHLRVTRQDGIATVTLDRPEKLNALTFGAYADLRDLLAELSRTRSVRALVLAGEGRGFCSGGDVDEIIGATLAMDTSDLLDFNRMTGQVVRAVRECPFPVIAAVHGVAAGAGAVLALAADFRIADPTARFAFLFTRVGLSGGDMGAAYLLPRVVGLGHATRILMLGEPVRAPEAERIGLLSELVDEGKADARAAELAARLAAGPALAHAQTKALLTAELDMPLAASVELDASTQALLMHGQDYAEFHAAFTGKRPPQWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I2A0</accession>
    <name>A0A0F4I2A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001845">
        <property type="protein sequence ID" value="KJY15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15814">
        <property type="protein sequence ID" value="KJY15814"/>
        <property type="gene ID" value="VR44_40785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7215" checksum="9FBB36A4073F1164" modified="2015-06-24" version="1" fragment="single">MGDPIEAQALLATYGQDRDTDEPLWLGSIKSNIGHTQAAAGAAGVIKMVQAMRHGVLPPTLHVDAPSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4W0</accession>
    <name>A0A0F4I4W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_40430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001746">
        <property type="protein sequence ID" value="KJY16503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16503">
        <property type="protein sequence ID" value="KJY16503"/>
        <property type="gene ID" value="VR44_40430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="KAsynt_C_assoc" evidence="2">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY16503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="21482" checksum="8490412B97494525" modified="2015-06-24" version="1" fragment="single">GHAQAAAGVGGVIKMVQAMHHGVLPRTLHADVPSSGIDWSAGAVELLTREQPWPETGRARRAGVSSFGASGTNAHVILEAAPEPLPAPGGEPVSGPVPVVLSGRSAEALRAQAGRLLSFLEARADLGPGEVAHALTRRAELEHRGAVVARDRETLVRGLTALASGEPDPAVVSGHTTGRGRPAVLFTGQGSQRPGMGRELYETFPAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I594</accession>
    <name>A0A0F4I594_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001689">
        <property type="protein sequence ID" value="KJY17155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17155">
        <property type="protein sequence ID" value="KJY17155"/>
        <property type="gene ID" value="VR44_40125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="127" mass="13181" checksum="5E06E7E9BD1F7555" modified="2015-06-24" version="1" fragment="single">MAKTRPARPGEAAALTALVRRSKAHWGYGAAFLAACAPELRVREEELTARRIVVAENGRGELLGLASLEDVEASEDAEDIAGGVNIAGGEEADGGPGRGGRTARLGLLFVEPSAIGRGVGRLLYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5J1</accession>
    <name>A0A0F4I5J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001680">
        <property type="protein sequence ID" value="KJY17265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17265">
        <property type="protein sequence ID" value="KJY17265"/>
        <property type="gene ID" value="VR44_40055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6351"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY17265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="11055" checksum="B8E291913DFE9FB6" modified="2015-06-24" version="1" fragment="single">AADEMIGLIALRRRSPLMGTISYILREDTWGNGYATDAAQQVVAFAFTTTGLDRVEAMHHPDNPASGRVLAKAGFTRTGTTDQPAGDGSAVPYETYAIRHQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I958</accession>
    <name>A0A0F4I958_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001634">
        <property type="protein sequence ID" value="KJY17998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17998">
        <property type="protein sequence ID" value="KJY17998"/>
        <property type="gene ID" value="VR44_39760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6134"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY17998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="515" mass="53353" checksum="9BEF3A5EFAD78225" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGT9</accession>
    <name>A0A0F4IGT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001481">
        <property type="protein sequence ID" value="KJY20884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952337.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001481.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20884">
        <property type="protein sequence ID" value="KJY20884"/>
        <property type="gene ID" value="VR44_38520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5355"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY20884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="36502" checksum="3BE7588B25450D08" modified="2015-06-24" version="1">MTAPKRAATGALIGLALGDALGFPTEFNDVPSILAKTGPWRQMRLPRPAIVTDDTQMTLALARGIRTAAERGRVGPLRLTRPVREEFVDWYHSPENNRAPGRTCLVACRLLDDPARDWRDASQVGSKGCGANMRVAPVGLVPGWTDEERAGAAQLQSALTHGHPTALAASDLTARAVHLLAQGTEVTGLVGRLRSYALENRTRYHERWLGDLWMRTASDASPESFIARGWDDCLAVLDRLAAALRTPSPETDPCLTTGEGWIAEEALATALHCFLLFPDEPLLALRRAACTSGDSDSLACLAGAFAGAHLGADAWPRDWEGGIEYRSELLSFGTLWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHM6</accession>
    <name>A0A0F4IHM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001454">
        <property type="protein sequence ID" value="KJY21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21502">
        <property type="protein sequence ID" value="KJY21502"/>
        <property type="gene ID" value="VR44_38260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5261"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="358" mass="34809" checksum="E66743453D12B6E7" modified="2015-06-24" version="1" fragment="single">GALAADRREAELRLLLARGGSRAGIAGRLLGEGAVTVLPAAAAATALAVLLLPTPRLAASLLSAAAVTLLALLALPVRAAFLLSPPRPAARRRRVVAELLVLAAAGAAVSEVRRRGVAPAGSGTDPLLIAAPLLLALCGALLLARLLPLVTGRLARAAGRSRGLVGYLGLVRAARGQGGSGAGTPGRGRSGPSVLPLIALLLAVTTAGFGAAVLQSVDTARLAVAHRTIGGDAGISVVGAGPLPDGLVKAAAALPGVRTSVPVWTDDDSSVLGTAGGGTRVTLVVAEPAAYAALSRALGCGAFDPALLGGGGTGSADAPVPVLFSAGLARQAGPGPSTLRPGPGGELQVRRAGVIGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKP6</accession>
    <name>A0A0F4IKP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001427">
        <property type="protein sequence ID" value="KJY22264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22264">
        <property type="protein sequence ID" value="KJY22264"/>
        <property type="gene ID" value="VR44_37985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5162"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7856" checksum="94D90E0056380384" modified="2015-06-24" version="1" fragment="single">MNARLNVFTSPVAAKAWKHIIAAGQALGDSTLPAATRELVMLRASQINGCAGCIDMHTKDATAAGESAVRLHLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQI0</accession>
    <name>A0A0F4IQI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001254">
        <property type="protein sequence ID" value="KJY24285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951830.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001254.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24285">
        <property type="protein sequence ID" value="KJY24285"/>
        <property type="gene ID" value="VR44_35815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4318"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="242" mass="26149" checksum="C0676254897D2753" modified="2015-06-24" version="1">MTVRTVRAYRRLSVEERRAQLLDAALSLFAHRAPEEISLDDVAEAAGVSRPLVYRYFPGGKQQLYEAALRSAADVLELCFAEPQAGPLTGRLSRVLDRYLAFVDEHDAGFAALLQGGSVVETSRTTATVDGIRRAAAEQILLHLDVPAPGPGPRLRMMVRTWITAVEAASLIWLDEGKQPEATTLRDWLVDQFIALLTATAATDPQTAAAARAALALEHPDGPAGLLARRVIPVVSEAAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQJ4</accession>
    <name>A0A0F4IQJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001368">
        <property type="protein sequence ID" value="KJY23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952112.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001368.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23763">
        <property type="protein sequence ID" value="KJY23763"/>
        <property type="gene ID" value="VR44_37335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4885"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470177" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="14938" checksum="8A28A963624EBF05" modified="2015-06-24" version="1">MRRKTARFAVSAATVAGLVMTAATSADASVLLGIGQGAGACPGSHVCLWSENDFVGATSGSKFGAIASNQNVGDLGKLQRDGALWTGMQDITSSVVNNTGNAICFYEHNNYGGLQFRIGPWEKWPSVPSWINDRISSFKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQQ1</accession>
    <name>A0A0F4IQQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001247">
        <property type="protein sequence ID" value="KJY24332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24332">
        <property type="protein sequence ID" value="KJY24332"/>
        <property type="gene ID" value="VR44_35670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4233"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="21707" checksum="DB4844403BFE9994" modified="2015-06-24" version="1" fragment="single">MRRSLREEFATRVVVADGAMGTMLQAADPTMDDFLGLEGCNEILNVTRPDIVRSVHDAYFAVGVDCVETNTFGTNLSALAEYGVEERIYELAEAGARIARESADAFTAADGRPRWVLGSMGPGTKLPTLGHIAYDRLRAAYQENAEGLIRGGADALLVETTQDLLQTKAAVIGARRALDWCGMGDLPLIVQVTVEATGTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRL4</accession>
    <name>A0A0F4IRL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001191">
        <property type="protein sequence ID" value="KJY24632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951631.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001191.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24632">
        <property type="protein sequence ID" value="KJY24632"/>
        <property type="gene ID" value="VR44_34765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4022"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16262" checksum="BC7A4FFDC10BAF11" modified="2015-06-24" version="1">MRLEAGGLSSSYALTGDAFVPRAIAALVGHDDGAVADIGGELVGRPETFFGAGRAFSVPGGTEKARYDVTVRISWAPDDRPPVFVPDLPACAPPVTAAGLEQAALEDPEGKDTKVDVHHNTAATASGTAGSSSSKGVGGLLCGLAPVAPAVWVGAAGTTNLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRS0</accession>
    <name>A0A0F4IRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001241">
        <property type="protein sequence ID" value="KJY24364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951787.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001241.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24364">
        <property type="protein sequence ID" value="KJY24364"/>
        <property type="gene ID" value="VR44_35595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4239"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="481" mass="49279" checksum="FF4C8EFBEF39BDE9" modified="2015-06-24" version="1">MSTVNPRRWWALGVLAAAQFMVIMDTSIIGVALPEMQKDLGFSQGELQWVFNAYVIVFGGLLLLGGRLSDLFGARKIFATGWVVMIVGSVLAAAAQSASVEIAGRAVQGVGGALIAPSAMTLLMMLFGHNPKELGKAMALYGAAAPAGGTAGVFLGGVFTEWVSWPWCFIIYVPIGVVTLALTKLLPAVQSRRGSVDVLGAIAVTAGLALAVFAVVRAPEFGWGSTATVLELIGAAVLLVLFFVIQKTTREPLMPLSVWRIPRLGSGNLAMTLLGAAWIPMWYFLNLYLQQVLGYGAFASGAALLPMTILLMIFMTAITARLMGRFGAKPLIVGGLVALALGLLWLSAVEPTGTFLVDVLPASLVAALGMALAYIPAMIASMSGAPQEQAGLASGIVNTTYNVGSALGLAALTALATTQGAGELGNLPALTDGFSSAFIAAAVIAAVGAVVTLLAMKSDKAVAAAAPAADAPASQGQTAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX5</accession>
    <name>A0A0F4ISX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001121">
        <property type="protein sequence ID" value="KJY25097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25097">
        <property type="protein sequence ID" value="KJY25097"/>
        <property type="gene ID" value="VR44_33415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3562"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="13794" checksum="0A5BB62C9DEFE30B" modified="2015-06-24" version="1" fragment="single">PGGLARVALATGAPVIPVAMIDTEKIQPPGKVVPKLMRPGIRIGKPLDFSRYQGMDGDRFILRSVTDEVMYEIMKLSGQEYVDIYATAAKRQIADAEKAAKEAARSDKAEKADTADTADGSNKGDKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISY2</accession>
    <name>A0A0F4ISY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_34970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001203">
        <property type="protein sequence ID" value="KJY24568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951674.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001203.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24568">
        <property type="protein sequence ID" value="KJY24568"/>
        <property type="gene ID" value="VR44_34970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4073"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9987" checksum="8B2A4DE7844EAFF0" modified="2015-06-24" version="1">MLERQQLKDRTRVTFVLPEGAPEGPVSVVGDFNQWDPSAHPLTPRGDGTRAVTVALPARGSHSFRYLAAGDYWFDDEQADGHDGANGRLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITF6</accession>
    <name>A0A0F4ITF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_34380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001172">
        <property type="protein sequence ID" value="KJY24763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951565.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001172.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene854"/>
    <dbReference type="EnsemblBacteria" id="KJY24763">
        <property type="protein sequence ID" value="KJY24763"/>
        <property type="gene ID" value="VR44_34380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470398" description="Histidine kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="235"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY24763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="448" mass="46257" checksum="B1B98BB9E65336C0" modified="2015-06-24" version="1" fragment="single">MRWALVKVCLAVTTMVAVAFAVPLGLVVQEMASDRAFSNAERQAATMGPTLSITTDPVQLRKAVESTEMGAARRMAVHVPAIGGAAPVDIGDGWAGAHAVAETRSMGRATTAAAGGGGSALLQPIALGSGDIAVIEIYVPESEVSNGVATAWLILAGVGLALVVGSVAVADRLGARLVRPAERLADAAHQLGEGRLGARVPEAGPKELRSAAVAFNSMADQVVELLANERELAADLSHRLRTPLTVLRLNAASLGDGPAAEHTRAAVEQLEREVDTIIRTAREQRQPAAAAATAGCDASEVIRDRMAFWSALAEDEGREVRLAGVDRTVRVPVARPELAAALDALLGNVFRHTPEATPFAVDVHDAGDAVIVLVSDAGPGIADPDAALRRGNDGGRDGSTGLGLDIVRRVAESTGGDVRLGRSVLGGTEVRVWLALDGRARRGGRVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITT3</accession>
    <name>A0A0F4ITT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_34020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001151">
        <property type="protein sequence ID" value="KJY24898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951500.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24898">
        <property type="protein sequence ID" value="KJY24898"/>
        <property type="gene ID" value="VR44_34020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3730"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="455" mass="47362" checksum="C4A93BD64E0DB652" modified="2015-06-24" version="1">MVSPAANRTSPSGIRRIVAASLVGTTIEWYDFFLYGSAAALVFNTLFFPAGDPLVGTLLAFLTYAVGFAARPLGGVVFGHFGDRIGRKRLLVVSLLMMGGATFAIGLLPTYASVGALAPVLLTLLRLVQGFALGGEWGGAVLLVAEHGDDRSRGFWASWPQAGAPGGNLLATGVLALLAAVQSDEAFLAWGWRVPFLLSGVLVVVGLWIRVSVSESPAFLEARARAEAEEAAGLRQRPPVVEVFRSHGRDVVTAIGVRLGENVSYYVLTAFLLVYVTVHLHLPKSDALNAVLIGSAVHFVTIPLWGALSDRIGRRAVTLVGAVGMAGWAFAFFALLDSRSFGVIAVAVTAGLLLHGAMYGPQAAFISEMFDTRVRYSGASMGSQLASLLGGALAPIVAVELLKDYGSSVPVSVYLCAAALVTAVAALAARETRGRSLDGARKAAPAASAGAPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUI0</accession>
    <name>A0A0F4IUI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_32855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01001095">
        <property type="protein sequence ID" value="KJY25299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951284.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25299">
        <property type="protein sequence ID" value="KJY25299"/>
        <property type="gene ID" value="VR44_32855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3389"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006986681" description="Serine protease" evidence="3">
        <location>
            <begin position="34"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="290" mass="29870" checksum="1B7389C8EC2324C3" modified="2015-06-24" version="1">MLRQGKAGGIMAVDKRSVVTAVLCGVAALGASAAVAELVPPPEATAPVHAKSAAPSGSSTGPSRSQASKPQLTKPQQAPAAPKPGNATAFTGALFTGGLDGDHFCTATVVRSPGKNMLITAGHCLLEGQQSRDGGAVFAPAYANGVAPYGVWKIEQVYEDKRWADDTDDDYDLAFARLAPDDKGRNIEDLTGGATLDTSGRAGEEVTVTGYPADRKVPRTCTAVAVRTSEREQRFDCADFPGGTSGSAWLGRDGKIIGILTGGDTDDVSTSTVLGDYAAQLYAKATAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUL0</accession>
    <name>A0A0F4IUL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycothiol maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001113">
        <property type="protein sequence ID" value="KJY25163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951352.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001113.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25163">
        <property type="protein sequence ID" value="KJY25163"/>
        <property type="gene ID" value="VR44_33220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3519"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="231" mass="25029" checksum="E31ABC7CE062D1DA" modified="2015-06-24" version="1">MTDHVHDLASVREATERLLNAVAKLDNASLSQESHLPGWTRGHILAHLARNADALVNVLEGRPMYESAAARDADIERDAGRPLEEHLTDLRDSGARFLATTGPDQDWQRTVELRNGVTDLAANVPFRRLVEVELHHVDLNVGYELSDLPEEFTDREIAFLADRWSGRPDVPPVTLTGPDGSPVARTGGTEGTPVTLSGPKDELLGWLAGRGPKGAHLTVEAGEGLPELPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW25</accession>
    <name>A0A0F4IW25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000971">
        <property type="protein sequence ID" value="KJY26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950880.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000971.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26212">
        <property type="protein sequence ID" value="KJY26212"/>
        <property type="gene ID" value="VR44_30655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2585"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="25642" checksum="0EA7719F9E87A4B8" modified="2015-06-24" version="1" fragment="single">VKVYEDPDELFADCDVVAFALPPDVQAPLAVRAAAAGCHLLLDKPVATTVADARAVADAATAHGVASVVFLTLRFAEPTAGWVLDQAKRSGWFTASAHWLGAVYPPDGEPSAYAESPWRKAKGGLWDVGPHALSVLIPVLGDVTAVTAGRGPSDLVQLALRHASGAASTAVLSLSAPRAAAGVGLELRGAEGVFSLPDWSDVPGAYGRALDAVLTAARTGVPDPRGAEFGARLTEILAEAESQLAAAAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWU6</accession>
    <name>A0A0F4IWU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000935">
        <property type="protein sequence ID" value="KJY26482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950755.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000935.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26482">
        <property type="protein sequence ID" value="KJY26482"/>
        <property type="gene ID" value="VR44_29960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2374"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470204" evidence="2">
        <location>
            <begin position="28"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="316" mass="33634" checksum="150622EF0C0715AD" modified="2015-06-24" version="1">MLAWSVRISGLLAFTAAAALAVWTAGLADGVPLPAPGLTELAWVVGGLVWLRVLALWAWWFDEEYGWLPTRPERPVSLTKGGRPGPLRRLADREYESTAWVFLRQSAVWSLVVTAIAAMNVLGSSHGSPYVHSLLQAGAAYTTAIVAEVSDVDEVRNGDEELVGYHTTLVVTTPQGSRVRSDTAFTPHRPEPGDQVRILWAPTAPELGGLVGTDEPLDRYLKRDWGPTLRGVGPAALALLLVLTCMLPTAVGAEADGLQEQAWSPFAQTVHAAAITAVLAAALPYLTGTLDNGYLGLAAVGLLALYIAMPVRALMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX00</accession>
    <name>A0A0F4IX00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate (Pro-3S)-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_33100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001107">
        <property type="protein sequence ID" value="KJY25211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951330.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001107.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3636"/>
    <dbReference type="EnsemblBacteria" id="KJY25211">
        <property type="protein sequence ID" value="KJY25211"/>
        <property type="gene ID" value="VR44_33100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3492"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="324" mass="35348" checksum="9317460047510B71" modified="2015-06-24" version="1">MTTPTSPVNRLRPRRSCLAVPGSNPRFLEKAQGLPADQVFLDLEDACAPLAKEGARHTIVDALNNGDWTGKTRVVRVNDWTTHWTYRDVITVVEGAGQNLDCIMLPKVQDAQQVVALDLLLTQIEKTMGFEVGKIGIEAQIENAKGLVNVDEIAAASPRLETIIFGPADFMASINMKSLVVGMQPPGYPADAYHYILMRILMAARTHNLQAIDGPFLQIRDVDAYREVAGRAAALGFDGKWVLHPGQVEAANEVFSPSQEDYDHAELILDAYDWCTSEAGGKKGSAMLGDEMIDEASRKMALVIAGKGRAAGMQRTTKFEIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX21</accession>
    <name>A0A0F4IX21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADH_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001000">
        <property type="protein sequence ID" value="KJY25988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25988">
        <property type="protein sequence ID" value="KJY25988"/>
        <property type="gene ID" value="VR44_31080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="116" mass="12075" checksum="136F58DDF4968333" modified="2015-06-24" version="1" fragment="single">MTSTSLTEFARRDETVAAEMRALRLSATYDGSGFGQLDLVRMPVPVPGPTEVLVRVALCGICGTDTDACRFRPDGTSTFGGPISLPVVLGHEAAGEVVRTGALVTRVGPGDLVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXW0</accession>
    <name>A0A0F4IXW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000957">
        <property type="protein sequence ID" value="KJY26303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950834.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000957.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26303">
        <property type="protein sequence ID" value="KJY26303"/>
        <property type="gene ID" value="VR44_30360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2484"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="419" mass="47359" checksum="6750E9EAFAE2A5AB" modified="2015-06-24" version="1">MHEAVAAATKSTPEYRQCPYPVYRTLREQAPIARLTPGHGVDTYLITRYEDAHAILADPRIGKDMHEGIDLYHALFGDLCEALDDNLLFADPPRHTRLRHIAKTAFTPRHIHALRPHIEELAHGLLDRCPTDRPVDLMQAFALPLPVMVICELLGIVGQERTEVLKWFAVVTRSRFNKDLKGDLEEAEIWLRDYFARHIHRTRQQPTDDFLTMLVETPHEEEPLTDDELVSMIWVLLFAGHKTTTLQIGNCVFSLLTHPDQLRAVQENRELLPQAIEEMQRFEGSVETSTFRYALEDVEIGGTVIPKGAVVQIALNSANRDPEKFPDPDTLDFTREGLQSSHLGFGYGAHYCLGAPLARLELEICLTALLDRFPDMVLAMPTPAEGDWLKGPFPAFRGLERLPVALDPSRTVDDWTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY20</accession>
    <name>A0A0F4IY20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000887">
        <property type="protein sequence ID" value="KJY26915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26915">
        <property type="protein sequence ID" value="KJY26915"/>
        <property type="gene ID" value="VR44_28915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2123"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="632"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY26915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="764" mass="80608" checksum="4836B84EC07DFE71" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY51</accession>
    <name>A0A0F4IY51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000923">
        <property type="protein sequence ID" value="KJY26589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950710.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000923.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26589">
        <property type="protein sequence ID" value="KJY26589"/>
        <property type="gene ID" value="VR44_29710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2319"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="104"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="24689" checksum="29F7F082B7C2EB55" modified="2015-06-24" version="1" fragment="single">STPPAPQPAAPAKGPLTGRTVVIDPGHNTGNFKHGREIDQQVDIGTNRKECDTTGTTTNSGYMEAEFSLDVSHRARALLEAKGAKVVLTHDGDRPWGPCIDERARIGNQAAADAVVSVHADGASAGNRGFHVILPARVKAGAADTAKIVGPSRDLGERIASNFARATGSSPANYLGSGTGLVVRDDLGGLNLSTRPKVFLECGNMRDEKDAAQLMSPEWRQKAAQGIADGITGFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY99</accession>
    <name>A0A0F4IY99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001040">
        <property type="protein sequence ID" value="KJY25656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25656">
        <property type="protein sequence ID" value="KJY25656"/>
        <property type="gene ID" value="VR44_31920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041116">
        <property type="entry name" value="SLATT_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18184">
        <property type="entry name" value="SLATT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_3" evidence="2">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11706" checksum="E5727BE6D700A8CD" modified="2015-06-24" version="1" fragment="single">MTFRNEDLPALFHQTDQAAVSRQRESVQATRAQLVLLVVAAGAAALPSGPAAGGLHLFAALSALAYAGVLAVGVRATRRRARPQWQLNRSAAEFIKSLAWRYAVHGAPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYE4</accession>
    <name>A0A0F4IYE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000875">
        <property type="protein sequence ID" value="KJY27050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27050">
        <property type="protein sequence ID" value="KJY27050"/>
        <property type="gene ID" value="VR44_28480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2022"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6461" checksum="63FEBC4781652D89" modified="2015-06-24" version="1" fragment="single">HEADVAVIVTTSSFTAPAVEYADTCGIVPVDGGALAAWTEQETPPPWASAAGAPEPGHVFPGGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYE5</accession>
    <name>A0A0F4IYE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000910">
        <property type="protein sequence ID" value="KJY26689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26689">
        <property type="protein sequence ID" value="KJY26689"/>
        <property type="gene ID" value="VR44_29415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2247"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="18479" checksum="5D98C7DA82645DC4" modified="2015-06-24" version="1" fragment="single">TRLTAAAVAAVNEAEAPVVEVPVVEAPAPVVAPVAEAPAPVVAEEAQVVKPRRTRTRKAAVAEAPAVEAPVAEAAPAVAEEAPAKPKRTRTRKAAAVAEAPEAEAPAAAAPVVEAAAPVRPRRVPTRKAAPTPIPDVVLPEDAVAPRRPRARKVVAPAAEPQFQIAPPSEPVRTTRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYW5</accession>
    <name>A0A0F4IYW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">VR44_28190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000858">
        <property type="protein sequence ID" value="KJY27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950430.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000858.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2563"/>
    <dbReference type="EnsemblBacteria" id="KJY27215">
        <property type="protein sequence ID" value="KJY27215"/>
        <property type="gene ID" value="VR44_28190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1880"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16726" checksum="E04A16ED2EBB749C" modified="2015-06-24" version="1">MTATDRSIELITTAAQAAADRLAHDIIAYDVSDVLSITDAFLLASAPNDRQVKSIVDEIEERLLKELGAKPVRREGDRDARWILLDYVDIVVHVQHSEERVFYALERLWKDCPEIELPEDAKLTIGKAEEHAKLREAQGDDELDGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZL9</accession>
    <name>A0A0F4IZL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen fixation protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_27450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000831">
        <property type="protein sequence ID" value="KJY27460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950299.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000831.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5371"/>
    <dbReference type="EnsemblBacteria" id="KJY27460">
        <property type="protein sequence ID" value="KJY27460"/>
        <property type="gene ID" value="VR44_27450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1658"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY27460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16953" checksum="DA065DDA9F582219" modified="2015-06-24" version="1">MKLDSMYQELILDHYKHPHGRGLRDGDAEVHHVNPTCGDEITLRVKYDGETLTDVSYEGQGCSISQASASVLNELLVGKELSEAQRIQAVFLELMQSKGKIEPDEEMEEVLEDAVAFAGVSKYPARVKCALLSWMAWKDATAQVLGDAERKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J078</accession>
    <name>A0A0F4J078_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000953">
        <property type="protein sequence ID" value="KJY26326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950816.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000953.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26326">
        <property type="protein sequence ID" value="KJY26326"/>
        <property type="gene ID" value="VR44_30300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2470"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="288" mass="28443" checksum="D72C1C5995FA05BB" modified="2015-06-24" version="1">MTALFALATALLWGLADFGGGLLTRRLPALTVVVVSQIAAVLVLGSVVLATGAWHEAGPQLWFAVAAGLVGPAAMLSFYKALALGPMGVVSPLGSVGVVVPVGVGLVLGERPGPGQFAGIAVAVVGIVLAGGPELRGAPVQRQAVVLTLVAAFGFGAVMALISQASTTVTGLFLALLVQRVTNVAVGGAALWAQTRRGVPALPEGTGPRVLWGLLPALAFVGLADVAANGTYSLAAQNGPVTVAAVLSSLYPVITALAAFAVLKERLRSVQAAGAGLALAGTVLLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0I1</accession>
    <name>A0A0F4J0I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_28115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950418.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3083"/>
    <dbReference type="EnsemblBacteria" id="KJY27238">
        <property type="protein sequence ID" value="KJY27238"/>
        <property type="gene ID" value="VR44_28115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1866"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="277"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="400" mass="41096" checksum="32ACE4B3056CE282" modified="2015-06-24" version="1">MSGTNNTTSVIVAGARTPMGRLLGSLKSFSGADLGGFAIKSALERAGISGDQVQYVIMGQVLQAGAGQIPARQAAVKAGIPMNVPALTINKVCLSGLDAIALADQLIRAGEFDIVVAGGQESMTNAPHLLPKSREGYKYGAIEMLDAMAYDGLTDAFENIAMGESTEKHNTRLGIERAPQDEFAAASHQRAAAAQKNGVFEAEITPVEIPQRKGDPVIFAADEGIRPETTVESLGKLRPAFAKDGTITAGTSSQISDGAAAVVVMSKAKAEELGLDWIAEIGAHGNVAGPDNSLQSQPSNAILHALKKEGLEVSDLDLIEINEAFAAVAVQSMKDLGVTPEKVNVNGGAIALGHPIGMSGARVVLHLALELKRRGGGVGAAALCGGGGQGDALVIRVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0P5</accession>
    <name>A0A0F4J0P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000849">
        <property type="protein sequence ID" value="KJY27313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042809690.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000849.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene205"/>
    <dbReference type="EnsemblBacteria" id="KJY27313">
        <property type="protein sequence ID" value="KJY27313"/>
        <property type="gene ID" value="VR44_27900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1829"/>
    <dbReference type="eggNOG" id="ENOG5033BDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="12099" checksum="E10ED922629DC399" modified="2015-06-24" version="1">MLMQGFDNGVLPLLGYAMLALAVVAFVLALLAREDAYRAADKQTKTFWLVILGVTVLVDFFLGMLFLQIAGLVASIVFFVDVRPALKQVSGGGNRRRGGSSSDGPYGPYNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J132</accession>
    <name>A0A0F4J132_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000778">
        <property type="protein sequence ID" value="KJY27967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950091.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000778.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1201"/>
    <dbReference type="EnsemblBacteria" id="KJY27967">
        <property type="protein sequence ID" value="KJY27967"/>
        <property type="gene ID" value="VR44_26345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1424"/>
    <dbReference type="eggNOG" id="COG1946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="33917" checksum="AA1A6F1B9903C661" modified="2015-06-24" version="1">MTNPAERLVDLLDLEQIEVNIFRGASPQESLQRVFGGQVAGQALVAAGRTTESDRPVHSLHAYFLRPGIPGVPIVYQVERVRDGRSFTTRRVTAVQQGKTIFNLTASFHHPEEGSIEHQLPPRLDFPHPDALPKVVDEIREHLGALPEALERMARRQPFDIRYVDRLRWTPEELKDADPRSAVWMRAVGPLGDDPLVHTCALTYASDMTLLDAVRIPVEPLWGMRGFDMASLDHAMWFHRPFRADEWFLYDQESPIAHGGRGLARGRIYDLEGRLLVSVVQEGLFRPYPAEKARPAVSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1S2</accession>
    <name>A0A0F4J1S2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_25845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000750">
        <property type="protein sequence ID" value="KJY28237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28237">
        <property type="protein sequence ID" value="KJY28237"/>
        <property type="gene ID" value="VR44_25845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1273"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="96" mass="9909" checksum="638FD56B1C586F0D" modified="2015-06-24" version="1">MTPAGILVDLTVLLVAAVATAAVRTPDPVRQAVVLSQLGLLLALLFTFLQAPDVALSQLAVGTVVTPLLILLTVRKIRRQGGTDGGAGRRGRGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2J9</accession>
    <name>A0A0F4J2J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950038.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000764.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28099">
        <property type="protein sequence ID" value="KJY28099"/>
        <property type="gene ID" value="VR44_26065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1368"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="16751" checksum="F69A4E7F9FAEA30C" modified="2015-06-24" version="1">MTQPRPAGVLTDLDAVLAEAPADSTGALWRLTGAGRGLDSNLVRLRPGAAIAEHAEPLLDVLLVVVAGGGRIDTPEGPHPLRPHSACWLPRGSRRSLTAGPEGLAYLTVHTRRPGLVIAPAAPTPAGGGEPACLLHRVCPACGRLATEPAAAYCSRCGTELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3F2</accession>
    <name>A0A0F4J3F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_25475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000736">
        <property type="protein sequence ID" value="KJY28379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949930.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000736.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene244"/>
    <dbReference type="EnsemblBacteria" id="KJY28379">
        <property type="protein sequence ID" value="KJY28379"/>
        <property type="gene ID" value="VR44_25475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1192"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="333" mass="34910" checksum="B5E4AAEE04DFC39D" modified="2015-06-24" version="1">MDTFALIVTIGVALGFTYTNGFHDSANAIATSVSTRALTPRAALAMAAVMNLAGAFLGSGVAHTVSQGLIETPQGNRGMWILFSALVGAIVWNLITWYFGLPSSSSHALFGGMVGAALAGGTEVLWGGVIDKVVIPMFLSPVVGLIVGYLVMVAILWMFRRANPHKAKRGFRIAQTVSAAGMALGHGLQDAQKTMGIVVMALVIADVQGADDPIPVWVKIACAVMLSLGTYAGGWRIMRTLGRKIIELDPPQGFAAETTGASIMFATAFLFKAPISTTHVITSAIMGVGATKRVNAVRWGVAKNIILGWFITMPAAALVAAVCFWLADLAFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3F8</accession>
    <name>A0A0F4J3F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_25855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000751">
        <property type="protein sequence ID" value="KJY28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950000.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000751.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28228">
        <property type="protein sequence ID" value="KJY28228"/>
        <property type="gene ID" value="VR44_25855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1276"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY28228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="98" mass="9980" checksum="47B9F4D7F88EB1A3" modified="2015-06-24" version="1" fragment="single">LHGLVTSRHAVHAIGCLSVVQSGTYVLLLAVGYRRGGTAPYFTDIPPGTLVTDPVAHALTLTDVVVGAAVSALLLALVLQTAKRHGTADPDALTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3L4</accession>
    <name>A0A0F4J3L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949921.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000734.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28424">
        <property type="protein sequence ID" value="KJY28424"/>
        <property type="gene ID" value="VR44_25425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1181"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19400" checksum="0AFC3B96B5905362" modified="2015-06-24" version="1">MRKLCTTLTSSLELEAPADPQTLFRALCDAMSRTRGGRPIVLRFERFPTELTTSGLWLNMEKYDIVVVEKYTTPDHQLVILGHELWHMNAGHCGEHGRRAADAARSLPDASSLTYESVAARSHYEDAQEIEAERFGLMLGDRCRAWLAGGESPAAGRRDGGVAGRIGSALGYRGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J454</accession>
    <name>A0A0F4J454_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VR44_26925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JZWV01000804">
        <property type="protein sequence ID" value="KJY27721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950202.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000804.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3052"/>
    <dbReference type="EnsemblBacteria" id="KJY27721">
        <property type="protein sequence ID" value="KJY27721"/>
        <property type="gene ID" value="VR44_26925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1546"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY27721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="879" mass="96274" checksum="892B8DB7D814821C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J479</accession>
    <name>A0A0F4J479_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_25005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000714">
        <property type="protein sequence ID" value="KJY28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949839.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000714.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000044_gene5949"/>
    <dbReference type="EnsemblBacteria" id="KJY28619">
        <property type="protein sequence ID" value="KJY28619"/>
        <property type="gene ID" value="VR44_25005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1089"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="529" mass="55041" checksum="1DA5CDD59B78456B" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4A5</accession>
    <name>A0A0F4J4A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_25130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000722">
        <property type="protein sequence ID" value="KJY28533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28533">
        <property type="protein sequence ID" value="KJY28533"/>
        <property type="gene ID" value="VR44_25130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1118"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="368" mass="38739" checksum="0D5A72DDB0D77C4A" modified="2015-06-24" version="1">MQWVISLAVVVVGLLTIRPMGPTGRGLAVAALFVVNSAALLARRLPEHKVPPRIAVGWLTLGVVAAAALIGLSSSGTGYLFAFFLAGHIGYRLETRQALVVAGFCSLLCGAVLYFRLGPGHEALPWVFGLATGAPVLIGIVNRSQRQAVRAAIDAAESAERAARAEARTAVLTERGRIARDVHDVLAHSLAGINMQLELADALIDTGDLEKVREAHAKAHSLVKESLKQAQWTVHALREDALPLRETLASMLASAGHRDVLTVTGTVREVPAQAVQNLLRIAQEALTNAARHAPGGAVSMELVFTPESTVLRIRNRPATRPAAPGAGSGMGLIGMRERVALLGGTLTAGPVTEGPHLGDWQVEAVIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4V2</accession>
    <name>A0A0F4J4V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000784">
        <property type="protein sequence ID" value="KJY27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950110.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000784.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27916">
        <property type="protein sequence ID" value="KJY27916"/>
        <property type="gene ID" value="VR44_26435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1471"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="24051" checksum="4F0B9DA2A0128B06" modified="2015-06-24" version="1">MISVIFDLDGTLVDSEPNYYESGRRTLERHGVPDFTWEQHARFIGIGTLETLELLKERYGLRAPVEQLLAEQNAAYLELARTRTEAFPEMRGLVERLHARGVPMAVASGSSREAIEAVLEGTGLSALLTTAVSAEEVERGKPAPDVFLEAARRLGAAPASCAVVEDAAPGALAARAAGMHCLAVPYVARSAGDPAFAGAGLLFAGGQAEFSAAAAEEWLGSLGGGWAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4V7</accession>
    <name>A0A0F4J4V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_23020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29407">
        <property type="protein sequence ID" value="KJY29407"/>
        <property type="gene ID" value="VR44_23020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7763" checksum="18925E1BE2C74A8C" modified="2015-06-24" version="1">MEGEGDDVQVLPSVLALVAADQAGRVELCQIVLDFDRTVFAAQRPQLSGDDGGLVADAALVVGLGEQAEEGPLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J5P4</accession>
    <name>A0A0F4J5P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 6-adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000637">
        <property type="protein sequence ID" value="KJY29510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949431.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000637.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29510">
        <property type="protein sequence ID" value="KJY29510"/>
        <property type="gene ID" value="VR44_22765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.485"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="170" mass="18836" checksum="C69BB2145A2C3023" modified="2015-06-24" version="1">MTVLQGASVVLGPTLTEDIPALAAIRATPEVRARWRGEDDLEAEIAGDLEDPGTICLTIRYGERIAGMIQWYSEEEPDYRHAGIDLFLDPALHGRGLGTDAVRTLARHLVDDRGYHRLVIDPAADNAAAIRCYEKVGFRPVGIMREYERGADGTWHDGLLMDLLAAELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6G4</accession>
    <name>A0A0F4J6G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VR44_25205</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="JZWV01000724">
        <property type="protein sequence ID" value="KJY28501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949879.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000724.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28501">
        <property type="protein sequence ID" value="KJY28501"/>
        <property type="gene ID" value="VR44_25205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1136"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="15">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_transf" evidence="15">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="16">
        <location>
            <begin position="197"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJY28501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="342" mass="37961" checksum="CEBD6FCB40314F38" modified="2015-06-24" version="1">MYTTVTRLADGRELIYYDSSPGRDRTAQDRRPLDRVESTPELRRDPATGDWVTIAAHRQTRTYHPPADACPLCPSRDGRQSEIPAADYEVAVFENRFPSLSGAAGRCEVVCFTPEHGAGFADLTPGRARLVLDAWTDRTAALSARPGVAQVYCFENRGAEIGVTLPHPHGQIYAFTTPTPRTAKHLAAAAAHRAATGRNLFEDLLAGARAATERVVLAGEHWTAFVPYAARWPYEVHLHPHRRVPDLTRLDEAERAEFPGLYLDLLRRFDRLFGLPEPTPYISAWHQAPLTGGEELALHLELFTVRRTADKLKYLAGTESGMDAFMNDVAPETAARRLREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7I9</accession>
    <name>A0A0F4J7I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000622">
        <property type="protein sequence ID" value="KJY29718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5178"/>
    <dbReference type="EnsemblBacteria" id="KJY29718">
        <property type="protein sequence ID" value="KJY29718"/>
        <property type="gene ID" value="VR44_22230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.331"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12425" checksum="5A38FBBAD9D63200" modified="2015-06-24" version="1" fragment="single">MTRGQAARLVRGRPAAAGPGGARQAAKMPFVLLVVALLAGGLISLLLLNSALNQGSFQLSKLKKETTALTDEQQALQRDVDGYSAPDALQRRARELGLVPGGSPVFLGPDGRTAAPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7M4</accession>
    <name>A0A0F4J7M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000615">
        <property type="protein sequence ID" value="KJY29794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949302.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000615.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29794">
        <property type="protein sequence ID" value="KJY29794"/>
        <property type="gene ID" value="VR44_22065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.293"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="226" mass="23630" checksum="1A9814D6E25F6A98" modified="2015-06-24" version="1">MMSVDEEQDPTAPVHGLQKALAVAAVVIAVPVTLWGVQLGPAPMFVVTCLATAVPLPALRSPRHFVGTCLAVGLSLLGWGVLGVMFGMVVFWPSALVLLLAAHADPRRRPVAAKAVGGIGAAITTAALVGYAAFAWHFHIGPALAEPHTFRAVTAPGLYRGVGAAEEHLKPFGATHVFGTESDEGSYLDVRFTEQLSAPGREKLRTEISRLPGITKVTLCPVPTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8R1</accession>
    <name>A0A0F4J8R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_21135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949122.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000588.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30133">
        <property type="protein sequence ID" value="KJY30133"/>
        <property type="gene ID" value="VR44_21135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8950"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470497" evidence="3">
        <location>
            <begin position="33"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="394" mass="39763" checksum="CD95DF461B321502" modified="2015-06-24" version="1">MPGLPALCLRPRDLRRGAVLTLLFAMSVGAAAATGAWGSAEAEGAPAAVLAGAGEPGAPPSPGTADREAVERAAAEAVAEGKSGKKAAQEVVSRSGDRWGTVYDQGEYAAFAEDLDGRWTGVGLWTGRRGDGRIEVDRVQPDSPAARAGLRAGDRLLSVDGHEVSGLPVADVVARLRGEAGTPVVLGIGRDGAVLTETVRREQLRADPVTVRRLEGGITVIKVASFTRGSGERVREAVREAPPGGGVMLDLRGNPGGLVTEAVAAASAFLDGGLVATYDVRGSERALYAAPGGDTGRPLVALVDGGTMSAAELVTGALQDRGRAVTVGTRTFGKGSVQMPTPLPGGAVAELTVGTYRTPAGRSLDGGGITPDLAAGDGAEERARKVLGGLGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8X7</accession>
    <name>A0A0F4J8X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000645">
        <property type="protein sequence ID" value="KJY29411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949483.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29411">
        <property type="protein sequence ID" value="KJY29411"/>
        <property type="gene ID" value="VR44_23055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.550"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="137" mass="15079" checksum="232D3DC79632A3F3" modified="2015-06-24" version="1">MEQENADGRPAIAAAVVVHGGRLLMVRRRVSEGRLSWQFPAGEVEPGEAREEAAVRETLEETGLAVRALKPLGERVHPDTGRVMSYTACEVVGGNAHVADSDELAEFAWVAHADISEYVPYSLFEPVQEHLDFVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J948</accession>
    <name>A0A0F4J948_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_19745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000545">
        <property type="protein sequence ID" value="KJY30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948870.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000545.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30705">
        <property type="protein sequence ID" value="KJY30705"/>
        <property type="gene ID" value="VR44_19745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8568"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="8">
        <location>
            <begin position="201"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="32448" checksum="BEF2D9B74345B489" modified="2015-06-24" version="1">MIPADLSHAVVHAVRRAVEAGELGGPVPARVVVERTRPGGVGEYASPVALRMGRGAEGALVLAKALALEPGIATVEVTGPGFLNFTLAPLSAAELVRDVAGRAGRYGCLPVAPQPAAGTRREDVRGAVVRGAVVRIREGQGLPGEGEGLSVAPVARRDGDVVARYGAAAAVWAMVVVPARETPVFGDGLLVQGEENEVFRVRYAHARARALTRNAADLGFRGEPGDVDAPALLRALADHPLALEAAAHHRAPERLARHLVVVADALLDFQHQVLPLGDEKPSAAHRARLALAEAAGAVLAGGLALLGIDAPHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAD9</accession>
    <name>A0A0F4JAD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000544">
        <property type="protein sequence ID" value="KJY30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948859.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000544.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30718">
        <property type="protein sequence ID" value="KJY30718"/>
        <property type="gene ID" value="VR44_19680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8551"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="27462" checksum="4A2CDB4A372ABEC0" modified="2015-06-24" version="1">MTTDQTLHPLQRPHPAPVVFGAGAAIGTLGGMIGLGGAEFRLPLLIGLFGFAALSAVILNKAMSLVVVLVALPARLAAVPAGEVAARWPVAVNLLAGSLLGAWAGASWAVRMRSTTLYRVLAVLMVLMAAALVLTHVTTLDTLALPLWAQIPAGVAAGLGIGVVAAIMGVAGGELLIPTIVLLFGEDIKTAGSLSLLVSLPTMLVAFARYSRDGSFAVLGANLRFTATMAAGSIAGAVLGGLLLGVFPDLVLIPALAVILLISAVKLARHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAU2</accession>
    <name>A0A0F4JAU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000591">
        <property type="protein sequence ID" value="KJY30086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5508"/>
    <dbReference type="EnsemblBacteria" id="KJY30086">
        <property type="protein sequence ID" value="KJY30086"/>
        <property type="gene ID" value="VR44_21260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8976"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="202" mass="20634" checksum="9690B1B7502C4D63" modified="2015-06-24" version="1">MAPMTVRTLVLASASPARLNLLRQAGLAPHVIVSGFDEDTLDHDEPAGLALALAEAKAGVVAELPEAAGALVIGCDSVLELDGEALGKPADAAEATARWKSMRGRAGVLRTGHCVIDTVTGRQVSATASTTVRFGEPTDAEVAAYVESGEPLHVAGAFTLDGLSSAFIDGIDGDPGNVIGLSMPLLRALLGELGVSITELWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBF5</accession>
    <name>A0A0F4JBF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31134">
        <property type="protein sequence ID" value="KJY31134"/>
        <property type="gene ID" value="VR44_18830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8377"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470786" evidence="2">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="17035" checksum="731F6AE15013437E" modified="2015-06-24" version="1">MAATPVISTAISAIMAGGTGIMAAAPMPAPTVEVALAAPAISLSASWSGPRPGNCARRVARSLTGTRGAFSMTRSAMYRAAFLALSPPLRTPFLTACIRRVPGLPRDSSSATVAGATAGAVSDGTTVVPEAGSPTAPGPVSGPVASACAPATGSPVFRKRSFRNGVGPVTAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC90</accession>
    <name>A0A0F4JC90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_17300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948411.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31830">
        <property type="protein sequence ID" value="KJY31830"/>
        <property type="gene ID" value="VR44_17300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7995"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="21689" checksum="2C13C60A02642B35" modified="2015-06-24" version="1">MTTHTGPDTDGLRRRWAATAAAAGADRDPAPYADRLLAAWAEPQRRYHTTAHLADVLARVDVLAAHAADPTAVELAAWFHDAVYRPDRSENEERSAPRLVRLTVTHDPAPGDTNGEALCDADLAVLAGDPDHPDDPAAYAAYAAAVRAEYAFVPDEAFRAGRAAVLRQLLALPRLFRTPYGAAHWEAPARRNLATELAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD22</accession>
    <name>A0A0F4JD22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30876">
        <property type="protein sequence ID" value="KJY30876"/>
        <property type="gene ID" value="VR44_19330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8473"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="25155" checksum="D23A5FD0B5D62D3D" modified="2015-06-24" version="1">MVDRDPPPTWRAAEESRLPQDPAQRDYLVDYAALMEAVPYPSFLVDHRWDVALTNSAFDRLFQAVRPHPTALPDDNFLRFVLFHPDAAAVLEDHEPAWCVPLLAQFATALSESPEDEGLRSIRQEVARDPFMEAAYRYGVPHWLTTHGQEAAEQDGAVRTVRHPDPGWGLVRCRMVAETSRMLDGMGLTRITLVLSAPQGLPTGPVRGGAGFPQQGARLRAVPALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDG3</accession>
    <name>A0A0F4JDG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">VR44_17280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000461">
        <property type="protein sequence ID" value="KJY31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948406.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000461.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000025_gene6295"/>
    <dbReference type="EnsemblBacteria" id="KJY31854">
        <property type="protein sequence ID" value="KJY31854"/>
        <property type="gene ID" value="VR44_17280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7991"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="265"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="416"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="505" mass="55105" checksum="261C70BFC61A763E" modified="2015-06-24" version="1">MADFVGAVDQGTTSTRFMIFDHAGNEVARHQLEHSQILPRSGWVEHDPVEIWERTNSVIQNALRHGNLSATDLAAIGITNQRETTVVWDPRTGRPYYNAIVWQDTRTDSIAAALERSGQGDVIRRKAGLPPATYFSGGKIQWILENVDGVREAAEQGHALFGNTDCWVLWNLTGGPDGGIHATDVTNASRTMLMDLETLDWDDELLGFFGVPRSMLPSINPSSHPEAYGHARSSRPLRAAIPITGVLGDQQAATVGQVCYAPGEAKNTYGTGNFLVLNTGTELVRSQHGLLTTVAYQFAGQPAVYALEGSIAVTGSAVQWLRDQLKVISDAAETERLASTVEDSGGIYFVPAFSGLFAPYWRSDARGAIVGLARYHDNGHLARATLEAICYQSRDVVEAMEQDSGVHLDVLKVDGGVTANDLCMQIQADVLGVPVSRPVVAETTALGAAYAAGLATGFWQDTDELRTHWQESKRWEPQWSEEQRAEGYAGWKKAVERTLDWAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE25</accession>
    <name>A0A0F4JE25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000445">
        <property type="protein sequence ID" value="KJY32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948314.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000445.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32054">
        <property type="protein sequence ID" value="KJY32054"/>
        <property type="gene ID" value="VR44_16775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8105" checksum="8078F6FD143D456C" modified="2015-06-24" version="1">MRRHEFQPGRLLAGLVLTAAGVLYLLDAAGKTDLPWFLVVPMAIGGLALAAVVGLVTYAVRRDRRDRIRESSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE85</accession>
    <name>A0A0F4JE85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_16560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948274.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32114">
        <property type="protein sequence ID" value="KJY32114"/>
        <property type="gene ID" value="VR44_16560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7744"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470395" evidence="3">
        <location>
            <begin position="28"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="280"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="532" mass="54826" checksum="594331787DED629B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JED1</accession>
    <name>A0A0F4JED1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000438">
        <property type="protein sequence ID" value="KJY32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948268.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000438.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32108">
        <property type="protein sequence ID" value="KJY32108"/>
        <property type="gene ID" value="VR44_16530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7738"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="243" mass="27329" checksum="A5A365AC46EE6EB7" modified="2015-06-24" version="1">MPKLNQIIAVEKGVKSKSLQELSQAHHDVQKPALLAGISRTYQPKDEEGEQLPPESTRVQVKAEDVLRATATTLTRLFDVTATKDWANRTAAADVVVDGNVLLAQVPVPYLLFLEKQLTDLHTFVRKLPVLDASESWNLDPSTDSWKTEPVRTIRTKKVPRNHVKAEATEKHPAQVEVYYEDVAVGYWTTVKFSGALPARRVNELLDRVERLQQAVKFAREEANGTEVTDQRVGDAVFGYLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JET9</accession>
    <name>A0A0F4JET9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000387">
        <property type="protein sequence ID" value="KJY32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32867">
        <property type="protein sequence ID" value="KJY32867"/>
        <property type="gene ID" value="VR44_15105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7440"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="190" mass="20337" checksum="DE31A26989CA87D4" modified="2015-06-24" version="1">MMRAQARPQDDLLSAEVHRGEHVVAVVRPVPRDLVQLPLAEYRRVHVLVARPPFGPTDVLLQGVPHGRAVGQPVRQAGAEQRIGAEQAQFAAELAVVVHGGHRGLLAGCGASDRAYDEAPGHLPRGFASDHLSARRDTLRRRRHHGSALHGAEASRSTPLHTIISSAGLRPVSTAGGRLFEGSPIDPHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF04</accession>
    <name>A0A0F4JF04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000484">
        <property type="protein sequence ID" value="KJY31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31546">
        <property type="protein sequence ID" value="KJY31546"/>
        <property type="gene ID" value="VR44_17910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8126"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="43109" checksum="3A671D975AD289CD" modified="2015-06-24" version="1">MTTHAEPILDFPFTWDGTHLPAQIGELAPVVKVRTIAGAEAWLVSSYELVKQVLEDDRFSLKNTSDPGVPRQYALTIPPEVVNNMGNITGAGLRKAVMKAINPKAPGLQEWMEEHAAELVERMLKHGAPVDIRSMFTDPFSEAMHCQILGIPHEAAPLLSESLPIAFMNSPREIPAARLNWDRDIAYMTARLDDTEQGLIGDLAKLRGTEGYEHVSDEMFATVGVTLFGAGVISTAGFLAMALVTLLTHPEEADHLADHPELMPQAVDELLRINLSIGDGLPRLAMEDMTLGEVEVKKGELVLVLPEGANFDPSVFPDPHRLDFTRANSSAHFSFGGGSHYCPATALGKKHAEIGLRAVLAAMPRLRLAVPVEQLVWRTGFMKRLPERLPVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFC2</accession>
    <name>A0A0F4JFC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947921.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33032">
        <property type="protein sequence ID" value="KJY33032"/>
        <property type="gene ID" value="VR44_14665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7260"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="398" mass="43716" checksum="18927F247D74D015" modified="2015-06-24" version="1">MMYAEERAEARIEDAGNVLVAPWALRGDDSVREFFGAVITPEELASGAVDLAGRTVYLCGDLSGIGGRQLDAADRVFVVRELSHGYRGGGGGEPWTVVGVGRVPLRVHGAGVYYRRFFHPDAGHFGRIRAEHEFQSLTESTKPGTAHRSGIYLTPVTRDGDELHFRLLRCSTNLSGPTEGFGPTDKAIVDALNREAAAVFRNPAPLNHVLAQIYHNSRATAERKQSKARISAHADKTKDMPVNGIMAFCTFYDGIEKLQPPNVSGLTSLRFRLKDTATGAALPPRFSVTLHPGSVFFMPLSTNRLYTHEIRPGALDADSLPTRLGYVVRCSNTEAVHKDGQTFLKRAGELVRLGRPTPEGMDHLRRLYAEENRTSSFIDYGGQFLFSMNTGDYVAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGE2</accession>
    <name>A0A0F4JGE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_15060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000386">
        <property type="protein sequence ID" value="KJY32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1661"/>
    <dbReference type="EnsemblBacteria" id="KJY32879">
        <property type="protein sequence ID" value="KJY32879"/>
        <property type="gene ID" value="VR44_15060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9694" checksum="4D7EF2151B38D36F" modified="2015-06-24" version="1" fragment="single">MATLLFLQERGRVTVPEVAAELEVSERTARRDLEALAASGIPVYSQRGRGGGWSLVGGARTNLTGLTAEEIRALFLVTGPLSATPELRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH91</accession>
    <name>A0A0F4JH91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ORF">VR44_14390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000371">
        <property type="protein sequence ID" value="KJY33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947873.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3326"/>
    <dbReference type="EnsemblBacteria" id="KJY33174">
        <property type="protein sequence ID" value="KJY33174"/>
        <property type="gene ID" value="VR44_14390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7227"/>
    <dbReference type="eggNOG" id="COG0214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="32394" checksum="33C1F3652D733EDD" modified="2015-06-24" version="1">MSTLPTSPQSAESAIGTSRVKRGMAEQLKGGVIMDVVNAEQAKIAEDAGAVAVMALERVPADIRKDGGVARMSDPNMIEEIIEAVSIPVMAKSRIGHFVEAQVLQSLGVDYIDESEVLTPADEINHSDKWAFTTPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGNVVEAVRHLRQIKNEIAQLRGYDNNELYAAAKELRAPYELVKEVAELGKLPVVLFSAGGVATPADAALMRQLGAEGVFVGSGIFKSGDPAKRAAAIVKATTFFDDPKVIADASRNLGEAMVGINCDTLPEAERYANRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHK5</accession>
    <name>A0A0F4JHK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000345">
        <property type="protein sequence ID" value="KJY33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33685">
        <property type="protein sequence ID" value="KJY33685"/>
        <property type="gene ID" value="VR44_13475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6945"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="173" mass="19601" checksum="CEC9BFCE74E5B17C" modified="2015-06-24" version="1">MTEHHMSDAAPSARRPYRVGYAPGAYDLFHIGHLNILRHARSQCDYLVAGVVSDEMAELAKGRRPMIPLVERLEIVRSVKYVDAAFVETVPDKVETWKQVRFDVIFKGDDWRGTPKGDKLERDFAAHGVDVVYFPYTVHTSSTQLRRALDVLAQPQAVPLHQPPAEPLTAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHQ1</accession>
    <name>A0A0F4JHQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000342">
        <property type="protein sequence ID" value="KJY33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33735">
        <property type="protein sequence ID" value="KJY33735"/>
        <property type="gene ID" value="VR44_13415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6919"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16407" checksum="08DC27D4D7797298" modified="2015-06-24" version="1" fragment="single">TVTTHDLPPTAAKLAGAHVELRDRLGLLTRPVEEERAEDAADTARWLRVLDGLGLEAKDEEGAVRALYAFLLRTPARLVGVWLPDAVGDRRPQNLPGTWDQYPNWRLPLADEAGRPLTLEALTASPRANALLGAVREGARTRTAPPGARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHV6</accession>
    <name>A0A0F4JHV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947817.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33353">
        <property type="protein sequence ID" value="KJY33353"/>
        <property type="gene ID" value="VR44_14060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7125"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14938" checksum="AF7E4CD049F39678" modified="2015-06-24" version="1">MVRRALTSVGTGDGAGGEEPGPVSRLWHVTLSVSGKPTPLAEVRRGLEQLAHDHPFLLTSRYADDHAEIRYWEEARDLHDAAAVALRLWGEHRSTAQLPPWEIVGLEVIDRTTYHQRVAEGYGPPPAHPVGVHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI36</accession>
    <name>A0A0F4JI36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_15590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000402">
        <property type="protein sequence ID" value="KJY32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32626">
        <property type="protein sequence ID" value="KJY32626"/>
        <property type="gene ID" value="VR44_15590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7518"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="149" mass="16516" checksum="800EC7598A0279AC" modified="2015-06-24" version="1" fragment="single">SAALGLATACLAERLDVYDDLPAEAREEALLRQIDTYIEHNLGDPELTPGAVAARHHISLRRLHLLFQGRPAGVAATIRGRRLAAARADLLRPDLTRRPVHSIAARWGFSSAAVFSRAFRQAYGTSPTELRRRRVARKVNDPCAQRTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI48</accession>
    <name>A0A0F4JI48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947630.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33895">
        <property type="protein sequence ID" value="KJY33895"/>
        <property type="gene ID" value="VR44_13025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6723"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03395">
        <property type="entry name" value="sphingomy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471061" evidence="1">
        <location>
            <begin position="35"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="329" mass="35180" checksum="DCF15844863AC1D5" modified="2015-06-24" version="1">MPQISHRSRAAATAAAATAAAAALALASAPAATAAGSGSAPRLSVLTYNTFLMSKNLYPNWGQDHRAAEIPKASFFQGHDVVVLQEAFDNGASDALKANASAQYPYQTPVVGRSKSGWDATGGSYSSTTPEDGGVTVLSKWPIVRKEQVVYKDACGSDWWSNKGFAYVVLDVNGTKVHVVGTHAQSTDSGCGTGEAAQMRSRQFKAIDAFLDAKNIPAGEQVIVAGDMNVDSRSAEYSSMLADLDLAPADARTGHPYSFDTALNSIANYRYPTDPREDLDYVLYRKGNARPSGWENNVVKEESTPWTVSSWGTSYTYSNLSDHYPVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI49</accession>
    <name>A0A0F4JI49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">vWA-TerF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_13930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000355">
        <property type="protein sequence ID" value="KJY33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33474">
        <property type="protein sequence ID" value="KJY33474"/>
        <property type="gene ID" value="VR44_13930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7072"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="vWA-TerF-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="26018" checksum="3B04CCBFFC5B5D3E" modified="2015-06-24" version="1" fragment="single">PQADPAPADAEPQAAAESQDAEPEADAAAGPAFPAAAVRRKGGAVPAAYKAAGQVLRGKGKSGARAKVYLVLDRSGSMRGFYKDGSAQYLADHALALAAHLDEEATVHTVFFSTELDGTAELTLDGHDEAWVEARHAELGRMGRTSYHVAVEAVVERYQKDGGTGPALVVFQTDGAPDNVRPARQAITDAAATAPGIHWQFVAFGDHDAKAFDFLRKLDAENAGFFHAGPAPTELTSAALLKGVLDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIW7</accession>
    <name>A0A0F4JIW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947978.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32906">
        <property type="protein sequence ID" value="KJY32906"/>
        <property type="gene ID" value="VR44_15020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7423"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="509" mass="54326" checksum="3A6033153FFB2F7D" modified="2015-06-24" version="1">MTQPAVSELDERVPGRRWTVRLDAVARTSTAVRISCSRPGCAEQQHPSAAAGRAAAAAHLKAHLCAAPAPTAEVYCACRLEGCRAHLPGPGRGRAEPWRCGGPVVVAVTTDREGRWWQAMECCSRCAAAIPGARTAATYRPPQPSNRPAPAPTGAGTPQFSDRQIVTDAVPAPRAAPRPAPARHRRPQAKIAQRVIPHDLRPVALRDELVELGDLFRAYQQREKPDLALLADLQERKARAFTAWADATGEGALRWEARRAEQAAATARSQHQARTGIIPLADGPTVVRLLTAPAQWEHTRSVLEHVADHTPLPGPEARLLVLLLTLRTASTGTGNLVGQDVAALGLTDPEDLIDKLTGCGWLVLPGTAGELLASRPENATPITVPSLAPGEDGPGPFTFGKKMRPKLSGWAQKVISDKKLRKAKATAATRLLALTLATRTNAAGDLGSDGQGVALGFLSARVPVDPRELQHLVDRLTAADWLTDPVITDTHLTGRLTERVLPLTCPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ79</accession>
    <name>A0A0F4JJ79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947502.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34250">
        <property type="protein sequence ID" value="KJY34250"/>
        <property type="gene ID" value="VR44_12360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6457"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="262" mass="27239" checksum="2463FC42A2613DE5" modified="2015-06-24" version="1">MPMTYQGTVALITGASAGLGVEFARQWAERGADLVLVARRLDRLEGLAAELEKRYGVTAHAVAADLALPGAAAALRAELDARGISVQTLVNNAGFGSHGPFARQDPAQINEMIQLNVVAVTELTRAFLPDLAADGRGALVTVASAAAYQPTPAMAVYGATKAFVLSFTEAVGYETRHSPLRVLAVSPGPVSTEFFDVVGSRDAAVGRMATPEQVVTAARRALERSKTPPSIVAGLANRVSALAAALTPRRVTLAVSGRILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJ89</accession>
    <name>A0A0F4JJ89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000302">
        <property type="protein sequence ID" value="KJY34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34260">
        <property type="protein sequence ID" value="KJY34260"/>
        <property type="gene ID" value="VR44_12260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6434"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="150" mass="15534" checksum="5F2CA3DBB44EEF25" modified="2015-06-24" version="1">MTGEAGFAARAEAVRDRYRSTLGAVPGGVQERLRLAGESGRLSTEEALAELRHIVLTDSPLGARVQQLVHFGQLLALGRPEPARIHARGALHAGAGIADLVGVAETALITAGVPAYALGTEIIAELLPPPDGGGRRQPERTDGGRPAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJD6</accession>
    <name>A0A0F4JJD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_12125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000298">
        <property type="protein sequence ID" value="KJY34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947457.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000298.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34315">
        <property type="protein sequence ID" value="KJY34315"/>
        <property type="gene ID" value="VR44_12125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6513"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13358" checksum="498DC15811D2F3B8" modified="2015-06-24" version="1">MANVEVSLKEAMTSIEGALGVALVDYASGMALGTLGGGKDLDLMVAAAGNTDVIRAKLRTMEMLGIQDEIEDLLITLGNQYHLIRIRRGRSGGGLFLYLVLDRGRSNLAMARHQLTRIEGDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJQ8</accession>
    <name>A0A0F4JJQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000370">
        <property type="protein sequence ID" value="KJY33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947862.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3337"/>
    <dbReference type="EnsemblBacteria" id="KJY33211">
        <property type="protein sequence ID" value="KJY33211"/>
        <property type="gene ID" value="VR44_14330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7215"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="409" mass="46048" checksum="3CC242013258A47E" modified="2015-06-24" version="1">MSSDPWGRVDETGTVYVRTSEGEQVVGSWQAGTPEEALAYFERKYEGLVVEIGLLERRVRTTDLSAKDAQTAIDHLRTQVDEHHAVGDLDALRVRLDKLVATVDSRREERKVQKAKQADEARAAKDALVTEAEQLAQSDQWRSAGERLRALVDIWKGLPRLDRKSDDELWHRFSHARSAFSKRRKAHFAALDAQREEARKAKEKLVAEAESLSKSTDWGPTAARYRELMDSWKAAGRAQREAEDDLWNRFRGAQDVFFAARGEVFAERDAEQVENLKLKEELAEEAEKLVPVTDLKAARAAFRSINERWEAIGHVPRDARPKVEGRMHAVERAIQEAEEGEWRRTNPEARARAAGLTGQLQAAVDKLRGEIDSARAAGNNAKADKLSRELEGRQALLDQALKGLEEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLC9</accession>
    <name>A0A0F4JLC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_10690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000240">
        <property type="protein sequence ID" value="KJY35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947189.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35152">
        <property type="protein sequence ID" value="KJY35152"/>
        <property type="gene ID" value="VR44_10690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5885"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="22880" checksum="CDFFBEAC8AFF9BE6" modified="2015-06-24" version="1">MDALISAVDLSGVLGVAAVATGMVLTPGPNMLYLVSRSITQGRRAGLMSLAGVVLGFLVYLSAVTAGIATLFTVVPVLYTAIKLAGAAYLLWLAWQAVRPGGTAVFSPQELPADSARKLVTMGFLTCLLNPKIAIMYISLLPQFVVPDRGHIAEQSFLLGLTQIAVAVTGNGLIAMSAGSIAAFLARRPAWLRIQRYAMGTVLAGLALNIAADRARAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLV9</accession>
    <name>A0A0F4JLV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000230">
        <property type="protein sequence ID" value="KJY35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947139.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000230.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35337">
        <property type="protein sequence ID" value="KJY35337"/>
        <property type="gene ID" value="VR44_10415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5956"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="599" mass="66404" checksum="CE90ADEEF223BB4B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMG3</accession>
    <name>A0A0F4JMG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_10960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000248">
        <property type="protein sequence ID" value="KJY35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947240.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000248.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35004">
        <property type="protein sequence ID" value="KJY35004"/>
        <property type="gene ID" value="VR44_10960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6075"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="541" mass="58360" checksum="7940A60D4267C50D" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNU4</accession>
    <name>A0A0F4JNU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000218">
        <property type="protein sequence ID" value="KJY35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947073.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35499">
        <property type="protein sequence ID" value="KJY35499"/>
        <property type="gene ID" value="VR44_10055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5610"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="7405" checksum="684F4ED244D00D58" modified="2015-06-24" version="1">MLWPMFAIALGFLGVAVLSVLAVRVFLEVRRLSGQVALASRRITEASGDLERAATDLAGAARREGALRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPA7</accession>
    <name>A0A0F4JPA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actinorhodin polyketide synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000207">
        <property type="protein sequence ID" value="KJY35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946969.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000207.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35679">
        <property type="protein sequence ID" value="KJY35679"/>
        <property type="gene ID" value="VR44_09495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5300"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="89" mass="9883" checksum="4FC21EF93920B7AE" modified="2015-06-24" version="1">MSKQEFTFDDLKRILLEGAGADEEVDLDGDILDTDFESLGYESLALLETGSRIEREFDITLDDDIFADHTTPRSLVEAINASLKVTVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQV2</accession>
    <name>A0A0F4JQV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000170">
        <property type="protein sequence ID" value="KJY36229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946757.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000170.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36229">
        <property type="protein sequence ID" value="KJY36229"/>
        <property type="gene ID" value="VR44_08370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4573"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23687" checksum="EB062743F5A0FB6E" modified="2015-06-24" version="1">MASRTSEKNSRQNRIAEMRRAEKARDRRNKIIAISVSTAVVAGLIGFGSWVIMEQKQKDRDTAAARKAPVDGEQSWDAKKLGRNHVETPVKYEMNPPVGGDHNPRWMNCNGDVYKNPVPEVNAVHSLEHGAVWVTYNDKAAKADVDALAGKVGKTPYTLMSPDKEQAGAIMLSAWGKQLTVEKADDPRVAQFFTKYVQGPQTPEPGAACTNGLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR18</accession>
    <name>A0A0F4JR18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Immediate-early protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000225">
        <property type="protein sequence ID" value="KJY35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947104.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000225.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35376">
        <property type="protein sequence ID" value="KJY35376"/>
        <property type="gene ID" value="VR44_10240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5915"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="16361" checksum="7A23CF1AC2E6B727" modified="2015-06-24" version="1">MPAFSLERTPPLTPAEAWRRLTEWPRHAEVVPLTRIEVLTAPPTRPGTRFVARSGLGPVSFDDVMEVTVWRPPVGGEPGLCRLEKRGRVVLGWAEIEVRPGAGSGSRVVWREELRIRFLPRLFDGVLNRTARLMFGRAATQLLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR61</accession>
    <name>A0A0F4JR61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000169">
        <property type="protein sequence ID" value="KJY36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946741.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000169.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36243">
        <property type="protein sequence ID" value="KJY36243"/>
        <property type="gene ID" value="VR44_08305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4560"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="356"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="732" mass="79698" checksum="B2571CFCE53A1155" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSC3</accession>
    <name>A0A0F4JSC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000194">
        <property type="protein sequence ID" value="KJY35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946884.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5136"/>
    <dbReference type="EnsemblBacteria" id="KJY35851">
        <property type="protein sequence ID" value="KJY35851"/>
        <property type="gene ID" value="VR44_09035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5070"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="28957" checksum="3AF9A1BA9FC80CCA" modified="2015-06-24" version="1">MSASKRRTRVHVVSDVHGNTDALARAGDGADALVCLGDLVLFLDYADHSRGIFPDLFGVENAHRIVELRTARRFTEAREFGRRLWDGLDRERMIEEAVRRQYAQMFAAFPSPTYATYGNVDIPALWPEYAGPGTTVLDGQRVEIGGRVFGFVGGGLPSPMRTPYEVDEDEYAAKVEALGEVDVLCSHIPPEVPELCYDTVARRFERGSAALLAAIRRTRPRYALFGHVHQPLARRMRIGGTECVNVGHFAATGRPWALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSZ0</accession>
    <name>A0A0F4JSZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946501.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36888">
        <property type="protein sequence ID" value="KJY36888"/>
        <property type="gene ID" value="VR44_06980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3611"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="248" mass="28088" checksum="C91144AA0881FBCC" modified="2015-06-24" version="1">MYDIATRKRALALLDDGRSLNSVSKETGISRAALRSWRTRIQPLPRLNQSAPCSGPADETAYAYLLGLYLGDGCISDHPRGGHHLRIFCDNAWPGLIQQCRAAILAVRPTDKVYVLQREGCVAVTSYGRHWTCLFPQHAPGKKHDRQIALEPWQQEIVDAHPWEFIRGLIHSDGCRITNWTVRNGKRYEYPRYFFTNKSDDIRRLCTDTLAKVGVQWTVLARGSDPFNVSIARKESVALMDAHVGPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK9</accession>
    <name>A0A0F4JVK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,3-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_06830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000126">
        <property type="protein sequence ID" value="KJY36986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946474.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36986">
        <property type="protein sequence ID" value="KJY36986"/>
        <property type="gene ID" value="VR44_06830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3446"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="5">
        <location>
            <begin position="305"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="489" mass="53279" checksum="A3F22DF3DFF2BD35" modified="2015-06-24" version="1">MTGFRGDPVLPGFRPDPSVCRVGADYYLVTSSFEWFPGLPVFHSRDLVGWRRIGSALDRASQLDLAGCAPSRGLFAPTIRHHDGVFHLVCTLMDGPGHFVVTATDPAGPWSRPQWLEGEGFDPSLFFDDGPDGGDGRAWFTAARVVDEAAGRTEIWMREYLPRERRLTGPEYVLWSGSRPGARWSEAPHLYRIDGTCLLLTAEGGTDVDHSVVAARAGHVTGPYEGAPGNPVLPPAGGPVTCTGHADLVRTPQGDWRAVLLGVRPGSAIGRETFLGHVAWEDGWPVFSPVHHTGRRRPVHDRFATLSADWSTLGTPPARFWTTGDGLRLRLRPERLGERTTPSLLARPQEQPDCDVSTELRFSPAAPDEEAGLAVVLDDDTHLLLLRTTEGLSLRRGPEVLARVPVPPGPVRLGVRIRGFGHTFAHAVPGGAWQDLPAVEATFLTPLFTSVQLGLYATSNGRPSTGEAHFTRFDITYPSRREPPGHRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVS3</accession>
    <name>A0A0F4JVS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000065">
        <property type="protein sequence ID" value="KJY38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5744"/>
    <dbReference type="EnsemblBacteria" id="KJY38452">
        <property type="protein sequence ID" value="KJY38452"/>
        <property type="gene ID" value="VR44_03530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8244"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="124" mass="13439" checksum="9FB297AECFDEEC29" modified="2015-06-24" version="1">MTAQRRVVAEVLDGEHVHLTADEVHARAVIKLPEISRATVYNTLGELVSLGEVLEVSTDRRAKRYDPNAHRPHHHLVCAQCGAIRDVHPAGDPLADLPAGERFGFVVSAVEVTYRGVCPNCAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWB8</accession>
    <name>A0A0F4JWB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000066">
        <property type="protein sequence ID" value="KJY38430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945880.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000066.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38430">
        <property type="protein sequence ID" value="KJY38430"/>
        <property type="gene ID" value="VR44_03585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8255"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="PTHR13136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="21761" checksum="3347B4A5F9366961" modified="2015-06-24" version="1">MTTRSETVDTPAGQARITWHTARAAKAVLALGHGAGGGIEARDLQALAAALPAHGCTVALVEQPWRVAGKKVAAAPKVLDEGWRALWPALAEPGLPVVAGGRSAGARVACRTAAGLGAAGVLALAFPLHPPGKPEKSRAEELLEAGRPTLVLQGGRDPFGRPEEFPAGEYELVEVAHGDHGFAVPKKADLTQDEALAVITGAVAPWLARLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX38</accession>
    <name>A0A0F4JX38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000054">
        <property type="protein sequence ID" value="KJY38710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38710">
        <property type="protein sequence ID" value="KJY38710"/>
        <property type="gene ID" value="VR44_03035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7339"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="10282" checksum="4F123F84DDDC8BD7" modified="2015-06-24" version="1" fragment="single">AQVDKIVFPVSIHEADSRRQSFGQVSNAFIRVVNMADDQELARYDLTEDASSETAMIFGEVYRYGGEWKFRAVGQGYASGLRGIALDFGVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX46</accession>
    <name>A0A0F4JX46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000053">
        <property type="protein sequence ID" value="KJY38720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945750.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38720">
        <property type="protein sequence ID" value="KJY38720"/>
        <property type="gene ID" value="VR44_02875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7306"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15709" checksum="7D644198A70F4057" modified="2015-06-24" version="1">MPSRRADPVTVEVVELIGDVVARYHMEYEEAAARHQLTGAQAKVLTLLSLEPLPMRRIAQKLRCEPSNVTGIIDRLETRGLVERRPDPADRRVKLAAPTEEGAETAERLRESLDFAREPLAGLSAEERTSLRDLLKRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXB8</accession>
    <name>A0A0F4JXB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_03780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945912.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38403">
        <property type="protein sequence ID" value="KJY38403"/>
        <property type="gene ID" value="VR44_03780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8659"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY38403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="27011" checksum="CE58FEF6F577B9A1" modified="2015-06-24" version="1">MSGGYAPPLCLTVAGSDSGGGAGIQADLKTMLALGVHGMSVVTAVTAQNSLGVKGAWELPAEAVTAQYRAVVDDIGVQAVKTGMLSSAVLVETVAELLAGTDAPVVVDPVGVSKHGDPLLAASALDAVRGRLLPRATVATPNLDEVAQLTGLAVEDEDGMRRAADAVLGFGPRWALIKGGHLAAHGGEAVDLLTDGSEEVWLRAPRHDNRHTHGTGCTLASAVAAGLAKGLSVPEAVTAAKEYVTGAIAAGFALGGGIGPVDHAWRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXN1</accession>
    <name>A0A0F4JXN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000063">
        <property type="protein sequence ID" value="KJY38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945866.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38483">
        <property type="protein sequence ID" value="KJY38483"/>
        <property type="gene ID" value="VR44_03505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8238"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="7077" checksum="6B96747E2E9D0490" modified="2015-06-24" version="1">MASLAWLLIPLFAAIGAAIWGSWAARDRTQGDISELAGYARFREAMDKADRARQKEKAHSGSDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXN5</accession>
    <name>A0A0F4JXN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000094">
        <property type="protein sequence ID" value="KJY37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946145.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000030_gene159"/>
    <dbReference type="EnsemblBacteria" id="KJY37756">
        <property type="protein sequence ID" value="KJY37756"/>
        <property type="gene ID" value="VR44_05080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1331"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="18581" checksum="D76E08D595696A30" modified="2015-06-24" version="1" fragment="single">EQAVAAGARLVNDVSGGLADPRMIPAVAATDVPFVVMHWRGFSDNMNSLAVYDDVLGEVTAELRARIDAVVTGGIAPERIVVDPGLGFAKNAEHDLALVARLPELRALGFPVLVAASRKRFLGLLAGAADAAPPPARERDAATAAVSAIAAHQGAWAVRGHEVRATADAVRVARAVEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JY35</accession>
    <name>A0A0F4JY35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_02440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39035">
        <property type="protein sequence ID" value="KJY39035"/>
        <property type="gene ID" value="VR44_02440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6778"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY39035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="27010" checksum="60BA0830D501EFED" modified="2015-06-24" version="1">MWLALYRRRRMLVALLLGMVAFEALIVVVAGALAPQELFSAGGKGPPGAYQAFSGSSGSVSIASYPGLLGAGLTHPFWIAMQLTAIGSLAAAAVAADVESGTVELVMVRPVSRARLLAERTAALMLAALALNLAATLTVAAGVALSPDVHRAVPIGGVFAAGVMGLGFALCLIGPAMAVSAAGRRRAQVIGATIAIGAVGFAVNFIALAWSPAAPLRFLSPFHYYTPGDALAEGGILWPQLGILVGAGALGTLLAHVLLRRRDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYZ9</accession>
    <name>A0A0F4JYZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-pyrone-4,6-dicarboxylate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000042">
        <property type="protein sequence ID" value="KJY38923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945708.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38923">
        <property type="protein sequence ID" value="KJY38923"/>
        <property type="gene ID" value="VR44_02640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6834"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="26149" checksum="366897B53D195A5D" modified="2015-06-24" version="1" fragment="single">MTTSFEKTPGWLDWYAGPTRPAFRVPEGAVDAHCHVFGPGAVFPFAPERKYTPCDASKDQLFELRDHLGFTRSVVVQATCHGADNSAMVDALRSSGGLARGVATVRPDVSDAELAELHEAGVRGVRFNFVKRLVDAAPRRDLREIAERIAPHGWHVVVYFEAADLAGLRDFFLSIPVPLVVDHMGRPDVTKDPYGPEFGAFLDFMRARPDIWCKVTCPERLSVSGPPALDGERSAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K074</accession>
    <name>A0A0F4K074_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39338">
        <property type="protein sequence ID" value="KJY39338"/>
        <property type="gene ID" value="VR44_01805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5765"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="217" mass="22907" checksum="A904FD2CD4678B02" modified="2015-06-24" version="1">MHMDLAVNVLDAQSVITAFGLIGILAIIFVETGLLVGFFLPGDSLLFLAGVGASGAAAEVFGRPDFHLSLPALLIGAPVAAVCGAQLGHLMGARLGPKLFARPNSRMFKQAHVAQAEAYFLRYGAGKAIVLARFVPVVRTFLNPVAGLLGVRGGTFFMWNAIGGVVWTVGITLLGYRLGDSLKGSIDSYMLPVIALIMIVSFSPVLIEVVRSRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K131</accession>
    <name>A0A0F4K131_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_01090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945423.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39643">
        <property type="protein sequence ID" value="KJY39643"/>
        <property type="gene ID" value="VR44_01090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2931"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="122"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="393" mass="42127" checksum="662B1CF0E97318CB" modified="2015-06-24" version="1">MVEGSMTQGAGQGPAMRTDTLRDFRVPVNEPAPYAVSAGLPGETPVYGEYPAYYTPETVPQQRAADTAHPEFPAAGPEDDLDGYTPTQRDLPVIGRGATGGPGDTVQVHYVPQEAPGTGPGPLYVVGDVHGYLDELIHELQAQNLIDADCHWSAGNARIWFLGDFTDRGPDGIGVIDLVMRLSAEAAAAGGYCKALMGNHELLLIGAKRFGDTPVNSGAGTATFQAAWLLNGGQRADMERLEDVHLQWMSRLDAATLADGHLLLHSDTTAYLDYGDSIEDVNDTIHELLNRNDADTTWDLFRKFTKRFAFRDEETGPQAVRQLLATYGGSRVVHGHSPIPYLLGEVGTEDGDDAHGPEAVDGPHVYADGLAIAMDGGVTMAGKLLVQQLPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K375</accession>
    <name>A0A0F4K375_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945400.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39621">
        <property type="protein sequence ID" value="KJY39621"/>
        <property type="gene ID" value="VR44_01005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2914"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="461" mass="48863" checksum="2745416DCC7672BD" modified="2015-06-24" version="1">MDALSEDLELLPSTRRALSHRIAVAQSEGRAPSVVAAVVRGGEVVWEGSRTSVEGHGPDGDVQYRVGSITKTFTAVLVLRLRDEGLLALSDPLGKHLPGTGADEVTIAQLLAHTGGLAAETPGEWWERTPGAQRPGLADVLGEEPFKHTPGTRHHYSNPGYTLLGSLVEALRGKPWEDVLRTEVLEPLGLHRTSGQPQAPHAGGWAVHPWADVMMPEPAEDLGLMAPAGQLWSTTRDLARFAVLLMHGDERVLSAESVREMRTAVAPPEPGLADAGYGLGLQLADQRGRRLAGHGGSLPGFVAGLWLSEADDVAAVVLSNCTSGLPASGVATDLLGIVADAEPRFPTPWRPFAEADRVPLELCGVWYWGTAPHGLRLKSDGSLELGPVGVTGRSARFRAGSDGTWTGLTGYYAGETLRAVRREDGSVSHLDLASFVFTREPYDPGAPVPGGVDPQGWRGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3V8</accession>
    <name>A0A0F4I3V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001726">
        <property type="protein sequence ID" value="KJY16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16675">
        <property type="protein sequence ID" value="KJY16675"/>
        <property type="gene ID" value="VR44_40330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_CoA_lig" evidence="1">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="24957" checksum="187F8A40D7DBE603" modified="2015-06-24" version="1" fragment="single">LLRRGEGLSSFVSAGNRADVSGNDILQYWYEDGATDVALMYLETLGNPRKFTRLARRTAAVKPLVVALGGRHTPAGHLVPGTRLPESTVSDLLRQAGVIRVDTVTELVDAGLLLAGQPLPAGPRVAILGNSESLGVLTYDACLTEGLRPSPPLDLTTAATPEDFRTALTAALASEDCDAVVVTAIPWVGERALADDLAEALREAVTEVPGKPVAVVHVELGELVEALSAARATAAPPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I6T7</accession>
    <name>A0A0F4I6T7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_39850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001650">
        <property type="protein sequence ID" value="KJY17725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952586.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001650.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17725">
        <property type="protein sequence ID" value="KJY17725"/>
        <property type="gene ID" value="VR44_39850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6271"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY17725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="177" mass="19319" checksum="2C7A05F7F640AEA8" modified="2015-06-24" version="1">MPPSPTLQRTEPEALAALQREHGRALFCFLLGLTAGDAQRAEDLVQETLVRVWQHPEVLATGHGSMRPWLFTVARRLAIDARRARLSRPQEVEPDGLEQAPAPEDAVAGSVTAIDVRRAVGSLGQEHREVLMQVYFQDRSVAEAAAELGIPAGTVKSRTYYALRALRKGLQGYGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I7T9</accession>
    <name>A0A0F4I7T9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_39735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001630">
        <property type="protein sequence ID" value="KJY18042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952565.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001630.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18042">
        <property type="protein sequence ID" value="KJY18042"/>
        <property type="gene ID" value="VR44_39735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6129"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY18042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22154" checksum="FFAC3A10703E9F74" modified="2015-06-24" version="1">MVKQERAARTRESLVHAAAEVFAEEGFTAASIAQISRRAGVTSGALHFHFEGKTSLALAVEERAARAMREAAAVNEERDRAGGPLQVLVGSTYTMLSLLTEDIGVRAAFALCADAGHESRLDLRRQWKLWTEGLLVAAEQAGLLAEGVSPQEATDLVVALTVGLDGLGGFEPGHGARQLLTRIWSVVLPGIANGEAAAAALIEAASGKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I8V3</accession>
    <name>A0A0F4I8V3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal peptidase I</fullName>
            <ecNumber evidence="2">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_39700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001624">
        <property type="protein sequence ID" value="KJY18094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18094">
        <property type="protein sequence ID" value="KJY18094"/>
        <property type="gene ID" value="VR44_39700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY18094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="145" mass="14902" checksum="8C29D0A733F0603F" modified="2015-06-24" version="1" fragment="single">MRRPGRGLGIAALAVLMAGLLMAAGGALVPRLLYRAASYSGSAMAPTYAKGDLVLFRKDPAEVRRGDVVLVTVGAMDGGEDPGGPVVERVVAVGGDTIAYEPGAPRLMLNGRPLDEPYVKDGEPTAGSPGPFSVTVPQAVSYTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I936</accession>
    <name>A0A0F4I936_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001604">
        <property type="protein sequence ID" value="KJY18457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952534.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001604.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18457">
        <property type="protein sequence ID" value="KJY18457"/>
        <property type="gene ID" value="VR44_39560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6024"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27234" checksum="C05D2F3183043B28" modified="2015-06-24" version="1">MTERADQQAPLQPMPADWRRALAVVAHPDDLEYGCAAAIAHWTDGGREVAYVLATRGEAGIDGVAPDECAALREAEQRASAAVVGVSTVEFLGHRDGVIEYGPALRRDIAAAIRRHRPELVITLNHRDTWGGADGGGNWNSPDHKAVGRAVLDAAGDAGNRWIFPELISEQGLEPWDGVRWVAVSGTTTPTHAVEAGPGLERAVHSLLEHKAYIAALTDQDPQEYVRNFLTGSVQQAAARFGGVPAVAFEVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I9D1</accession>
    <name>A0A0F4I9D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001628">
        <property type="protein sequence ID" value="KJY18083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952562.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001628.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18083">
        <property type="protein sequence ID" value="KJY18083"/>
        <property type="gene ID" value="VR44_39720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="254" mass="27268" checksum="803E072CD7601E99" modified="2015-06-24" version="1" fragment="single">MQRICVIGGSRYFGKLLVRRLLAAGHQVTVINRGSGRPPAGVEHLVVDRDDEEALLAALGPRTFDVVVDQVCYTPVQAAIAARVFAGRTRRYVMTSTIEVYDPATAALPPVPADTPVPEETVDPAAWPVDLDLPWHDGAYLEAHYAEGKRQAEAVLTRAGGFTFASVRSAHVLGGGAQEFTGRLAHYARRIRDGEPITVHARALPTVFIHFAELAELLRWAATEADFSGPLNACSDGPLDVRALAAAVAAQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IB56</accession>
    <name>A0A0F4IB56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001592">
        <property type="protein sequence ID" value="KJY18713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY18713">
        <property type="protein sequence ID" value="KJY18713"/>
        <property type="gene ID" value="VR44_39475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5984"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY18713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="187" mass="18823" checksum="FA721705AAF8F7BC" modified="2015-06-24" version="1" fragment="single">VLFSSAAGVFGAAGQANYAAANAFLDALARRRRTAGLPAVSLAWGLWAESSGITGELTDADRSRMSRSGVLPLATEEALGLFDAATAHPHSEVVPVRLDQAALRAQAAAGTLPALLTSLVRIPARRPAAGGAPDGAAGRAGAAGGDLTARLTGLSETERSTLVLDLVCEHVAAVLGLASPRAVRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IHZ2</accession>
    <name>A0A0F4IHZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001461">
        <property type="protein sequence ID" value="KJY21304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY21304">
        <property type="protein sequence ID" value="KJY21304"/>
        <property type="gene ID" value="VR44_38315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5272"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY21304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="56" mass="6258" checksum="D0139B4EE815CC03" modified="2015-06-24" version="1" fragment="single">MPTDDLPETFHVTTDEQLRAVSNLTRHRIMAVLRFEPATITQIADRVGLAKGSSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IPB0</accession>
    <name>A0A0F4IPB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_37025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001343">
        <property type="protein sequence ID" value="KJY23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23867">
        <property type="protein sequence ID" value="KJY23867"/>
        <property type="gene ID" value="VR44_37025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4791"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6665" checksum="75A1E93CB809FFAB" modified="2015-06-24" version="1" fragment="single">MCKGSGATPYRTVVDLTGPAYKCSCPSRKFPCKHALGLLLLWSAQGLGDPAEAPDWAAEWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRK6</accession>
    <name>A0A0F4IRK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall assembly/cell proliferation coordinating protein, KNR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001189">
        <property type="protein sequence ID" value="KJY24650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951623.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24650">
        <property type="protein sequence ID" value="KJY24650"/>
        <property type="gene ID" value="VR44_34705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4006"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="144" mass="15913" checksum="32F1FD6E59A1B836" modified="2015-06-24" version="1">MNWRELVLGLLPEAELAGPADEADLAEVERVLGQPLPGDLAGLLRQCDGVVGRHGTDVVWSARRIARQNAELRGTPVFASLYMPFEPLMFFGDSGGGDLFGAVRIPERCEVFVWDHESDGRSWAAGGTEDYLRRALPARGDWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS18</accession>
    <name>A0A0F4IS18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001164">
        <property type="protein sequence ID" value="KJY24820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951538.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001164.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24820">
        <property type="protein sequence ID" value="KJY24820"/>
        <property type="gene ID" value="VR44_34230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3817"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="75" mass="8513" checksum="AB77EE0AF6DDBB1E" modified="2015-06-24" version="1">MPHPTLTARAPELPALTPREQEVLAYLAQGDTYRMIACRMGLSPHTVDTYLRRLRSKTGAVNRTQLTHIAFRMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT03</accession>
    <name>A0A0F4IT03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001117">
        <property type="protein sequence ID" value="KJY25135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951376.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25135">
        <property type="protein sequence ID" value="KJY25135"/>
        <property type="gene ID" value="VR44_33310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3538"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="346" mass="37530" checksum="7854CA6D9A934379" modified="2015-06-24" version="1">MSQVTDHGGGVWGIKVPIPDNPLGHTLVHVLDTGSGPVLVDTGWDDPGSWDALTAGLGALGIAVADVHGVVITHHHPDHHGLSGKVREASGAWIAMHAADTEVVLRTRSADPGHWFDYMGEKLTAAGAPEEHVAPLRAARESGRTRTLPGLRAAVPDREIVPGELLPLPGRRMRAIWTPGHTPGHVCLHLEEAHPANLPGNGRLFSGDHLLPGISPHIGLYEAPEDTRVTDPLGDYLDSLERVGRLEPAEVLPAHQHPFTDAPARVRELLAHHEERLDGLWRLLLAEPLTPWGLAERMVWNRPWEQIPYGSRNIAVSEAEAHLRRLVKQGRAEAVTGTDPVAYRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT57</accession>
    <name>A0A0F4IT57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_34690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001189">
        <property type="protein sequence ID" value="KJY24648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951620.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001189.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24648">
        <property type="protein sequence ID" value="KJY24648"/>
        <property type="gene ID" value="VR44_34690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4003"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="273" mass="28476" checksum="E3FF06D84DF9C3FE" modified="2015-06-24" version="1">MNLTGVGRRYGRRRPWVLRGVEAQLPPGALVRIEGGNGGGKSTLLRLLAGIDTPTEGRITGRASRVAYVPERFPAVLPLTALAYLTHLGRVHGLTGAEAARRAADGLERFGASAYARTPLAELSKGSSQKVAVAQALLAEPGLLVLDEAWTGLDAPARAELDRAVTERTAAGGTVVFVDHDPARLAGLPDARYRLRDGSLEAVTADAPAVRTAVSAVRIRAVGPPGSVPPQGAVAAPGGGILLTVGADRSDAVLRELLTARPPWRIRAVEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITH5</accession>
    <name>A0A0F4ITH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001092">
        <property type="protein sequence ID" value="KJY25325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951277.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25325">
        <property type="protein sequence ID" value="KJY25325"/>
        <property type="gene ID" value="VR44_32820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3379"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="225" mass="23292" checksum="D0652AC9FDF8647F" modified="2015-06-24" version="1">MDLDEVLDALAAVGPFFTVPYGEEPPGPGFRPLTELYGEGLGPYVTEVGRRIGSGPGRVAASTAQFGIVSRLWSLGLGCAALGGRVPDLAPDRVWWQLPDGGSLRLWLPAPAAVLPAEALGETVLGNLAVLDTALRGTYGVSERVLRGNAASGLVGALRVLLDRVPGQRAVELAAALLADGGALAGTGEFIHEEGLGVAFVRRSCCLYYKVPGGGLCGDCVLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITY3</accession>
    <name>A0A0F4ITY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001119">
        <property type="protein sequence ID" value="KJY25109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25109">
        <property type="protein sequence ID" value="KJY25109"/>
        <property type="gene ID" value="VR44_33385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="14972" checksum="C5AAF3868B33DF06" modified="2015-06-24" version="1" fragment="single">MAATLKDATAIVGIGQTPFAKRLPASEKELACRAVLAALADAGIAPGEVDAFASYTMEETDEVEVAKAIGAGDVTFFSKVGYGGGGSCATVGHLAAAIATGQATVGVAWRSRKRGSGPRPWKNTAVQLPTPGQWTRPFGLLRPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IU84</accession>
    <name>A0A0F4IU84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001056">
        <property type="protein sequence ID" value="KJY25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951154.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25567">
        <property type="protein sequence ID" value="KJY25567"/>
        <property type="gene ID" value="VR44_32140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3146"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10926" checksum="A60589D88D655B11" modified="2015-06-24" version="1">MHYAKTLAVTAEREFLRYKKVTADGRTAGLGPSDLYDLLHLDRRADRVLPNGWCMLPPKQVCSKGNACLTCDKFVTDANHRDDLQHQLAQAEALITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUN6</accession>
    <name>A0A0F4IUN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_33180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001111">
        <property type="protein sequence ID" value="KJY25188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951349.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25188">
        <property type="protein sequence ID" value="KJY25188"/>
        <property type="gene ID" value="VR44_33180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3510"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="32621" checksum="6DC6D7BE41FD13C6" modified="2015-06-24" version="1">MLRGGPFHLALRAALAARGLPLHRVQHRLAARGIKLGVTSLSYWQQGARRPRQRESLRAVSALEEILELPEGSLLRLLADPDPAPGPARPAARPYRTLMSVGAAVERLLAAMELPADGGLHSVGHHERVRIGPAGELRTRESQQIVRAHRDGVDRYLAVHHGDPGCDATRVEVTAYENCRTGRVRCHPEAGVVVAELLFDARLRRGDTYVFGYGIEDGTGARSTEYVRGFSYAGGQYMLQVRFDEAALPVRCHRFARVSPGAPRRSLCDLTPSGGHRAVHLVEQAVRPGILGIAWDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUQ8</accession>
    <name>A0A0F4IUQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001029">
        <property type="protein sequence ID" value="KJY25755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951076.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25755">
        <property type="protein sequence ID" value="KJY25755"/>
        <property type="gene ID" value="VR44_31705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3051"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469848" evidence="1">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="11844" checksum="EB22EB5FB8E580D9" modified="2015-06-24" version="1">MFGAALWLAVGGVFAAAPQAAAATGGCPGGLVATLPLPDAEVRVYRSRTQVCAVNVALHPGERRHLAVSVQPRGGVPVGDAGQFTRYAGPVTVGAISRCVYVKGGVAAGSVESGWILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUW1</accession>
    <name>A0A0F4IUW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_35320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001226">
        <property type="protein sequence ID" value="KJY24451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951738.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001226.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24451">
        <property type="protein sequence ID" value="KJY24451"/>
        <property type="gene ID" value="VR44_35320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4176"/>
    <dbReference type="eggNOG" id="ENOG502ZDRZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470278" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6368" checksum="1029B559704ACF33" modified="2015-06-24" version="1">MPRLAVFAVVVCVLAVAAAVVAFVEGSFLGIVWVLLAGVTSNMAWFYVRKAKAEKQRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVB3</accession>
    <name>A0A0F4IVB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_31150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001004">
        <property type="protein sequence ID" value="KJY25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25960">
        <property type="protein sequence ID" value="KJY25960"/>
        <property type="gene ID" value="VR44_31150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2718"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9824" checksum="8CD168688D341549" modified="2015-06-24" version="1">MSKPLGIPLRGLLARAVARGYHWYALRTNVAKTRVLTNWLLNAVAGDDFVRMGLRASKLPTLREFEQTDAYLTPDQLRARTASRPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVL5</accession>
    <name>A0A0F4IVL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000986">
        <property type="protein sequence ID" value="KJY26075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26075">
        <property type="protein sequence ID" value="KJY26075"/>
        <property type="gene ID" value="VR44_30915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="11411" checksum="A036C729FBC79E27" modified="2015-06-24" version="1" fragment="single">MQKTALASFAHLPRTHHDRHVLTSTVDVFGVAHWLLADRAPQPGDARPFDALVVSVHPGGNVELTELSAVRARWPHLDRLPDSGFVVAASRTRRYENADQVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW22</accession>
    <name>A0A0F4IW22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FxsC C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_31910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001040">
        <property type="protein sequence ID" value="KJY25653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25653">
        <property type="protein sequence ID" value="KJY25653"/>
        <property type="gene ID" value="VR44_31910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3097"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="428" mass="47636" checksum="1E1F3825D8517CA9" modified="2015-06-24" version="1">MWVERLFRDLCNHIMALTSLPAGSEVGFMDREIRNGEGWSERLGAALATCRVFVPLFSPRYFASQMCGKEWFAFAQRAIQVGAVSDQKTEAIVPALWVPVPPSQLPLPAERLQFNHSTFGERYVTDGLYGLIKLRGYAEQYEHAVYELARHIVGVAETVRLKAVRPLDYRVVPSAFGPAGGRPGSPSARTLHVTVAAASRHDLPEGRSAEYYGENALEWNPYHPASRRPVAYVAEELVKNLNYQTTLASFDDEAGHFDSKQPPTRPEILIVDRWAVEDEHRRQRLAAFDQEHRPWINVVVPWNRYDHQSRAKEEELARRLEETLPVKMSQGRAACRAAANGVASMETLGQILPQVVEAAAQQFLRHAQAYPPAGHTPTERRRLVGPMGMSDPPPAPFPPTAHPYGPGGNDAADDSTETDRGDADDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW60</accession>
    <name>A0A0F4IW60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VR44_30465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000960">
        <property type="protein sequence ID" value="KJY26275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042819242.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000960.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5350"/>
    <dbReference type="EnsemblBacteria" id="KJY26275">
        <property type="protein sequence ID" value="KJY26275"/>
        <property type="gene ID" value="VR44_30465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2507"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY26275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="77" mass="7905" checksum="3881E8D38DDEC6CD" modified="2015-06-24" version="1">MGFSIALIVFSALLMLLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITVVVGLLWFACIVALGLLMKSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWD8</accession>
    <name>A0A0F4IWD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000951">
        <property type="protein sequence ID" value="KJY26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950806.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000951.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000023_gene6198"/>
    <dbReference type="EnsemblBacteria" id="KJY26342">
        <property type="protein sequence ID" value="KJY26342"/>
        <property type="gene ID" value="VR44_30245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="408" mass="44878" checksum="0A110AB34DEBB199" modified="2015-06-24" version="1" fragment="single">MPDDIARWLDEHAKPLSTLAPGAPVEDLKPLGEALRGTRIVGLGESTHGTSEFFRLKHRLLEFLVREEGFTTLAMEASQSAARALDAYVRYGTGSPERLVARLGFWTWRTREMVDIVEWLRAHNRALPEERRIRFVGTDPQLCADSVEAVAVFLRRTAPDQAGRMGALGVLARARPGSLPDPDKALMRRAEEISRLVAEHAGRSGPGNGADEALEHARILVRAADLVNRPFAASAEEEGVYAARDRYMAEAVARLVDDDPGARVVVWAHNGHIAKGTYGDQVPALGSRLRERYGDAYYALALLFGKGSFLARRGNDLQRPPARHRIGTGLRSLEARLTHALPGDYYADLRAAGSSVDAAPWLYAPHAQRSFGANVQRFLYRLNTAPLIPAEDYDGIAFVARSTCSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWK5</accession>
    <name>A0A0F4IWK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001018">
        <property type="protein sequence ID" value="KJY25853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951025.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25853">
        <property type="protein sequence ID" value="KJY25853"/>
        <property type="gene ID" value="VR44_31455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="265" mass="29160" checksum="B2F1B2D0142D63A5" modified="2015-06-24" version="1" fragment="single">MPVTARRRPAAPPKRSFLDKAAYVAAPGTVVLGLLYYFGNQYNEAYYRSFGVPLSDLPLSIQGVLARSPQALFFPVWVLLVCGLIALLALGRLGHALARPENERRRRTAYRSLLAVGLLLGIVGGYPVFFRDDLLTFLPASWPRLLLPPLVVALGVTLAFFAIQVRLGQHDPGRRSARVRDADRLWLVAGALLLGMLTLSLFYGVSRYAAMAGEAQAKVDADDGMKRSPAVELHSRLRLVHHAQGIEFEDLGAGAGPYRYQYRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWT5</accession>
    <name>A0A0F4IWT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001115">
        <property type="protein sequence ID" value="KJY25146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene33"/>
    <dbReference type="EnsemblBacteria" id="KJY25146">
        <property type="protein sequence ID" value="KJY25146"/>
        <property type="gene ID" value="VR44_33275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3531"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="19844" checksum="AC6905739E195078" modified="2015-06-24" version="1" fragment="single">MVISSTVPRLVIAAPSSGSGKTTVATGLMAAFAERGLAVSPHKTGPDYIDPGYHALATGRPGRNLDAFMCGPELVAPLFAHGAAGCDLAVVEGVMGLYDGAAGRGELASTAQVAKLLRAPVVLVVDASSQSRSVAALAHGFASFDPQVRLGGVILNKVGSDRHEAMLREALEEAGMPVLGVLRRAPQVATPSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX44</accession>
    <name>A0A0F4IX44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_29675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000923">
        <property type="protein sequence ID" value="KJY26582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950703.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000923.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4953"/>
    <dbReference type="EnsemblBacteria" id="KJY26582">
        <property type="protein sequence ID" value="KJY26582"/>
        <property type="gene ID" value="VR44_29675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2312"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="39"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="252"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="438" mass="47102" checksum="3F5B291B83783FF6" modified="2015-06-24" version="1">MTAEAMVTSPFEAFEASATDGDRPLRIALLTYKGNPFCGGQGVYVRHLSRELVKLGHSVEVIGAQPYPVLDTGATLTELPSLDLYRSPDPFRTPKRDEYRDWIDALEVATMWTGGFPEPLTFSLRARRHLQARAGEFDVIHDNQTLGYGLLGDLGAPLVTTIHHPITVDRKLDLAAAKDRKKRASVRRWYAFTRMQGRVARRLPSVLTVSGSSRQEIAEHLGVRDDRIHVVHIGADTDLWSPDPSVAEVPGRIVTTSSADVPLKGLVHLVEALAKLRTEQPDAHLVVVGKRAESGPVARAIEKYDLQDAVRFVKGITDAELVDLVRSAQVACVPSLYEGFSLPAAEAMATGTPLVATTGGAIPEVAGPDGETCLAVPPGDAGALAAALGRMLGDAGLRARLGAAGRQRVLARFTWAKAAEGTVAHYRAAIARTAARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IX66</accession>
    <name>A0A0F4IX66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000919">
        <property type="protein sequence ID" value="KJY26602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950698.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000919.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26602">
        <property type="protein sequence ID" value="KJY26602"/>
        <property type="gene ID" value="VR44_29650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2310"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="398" mass="41738" checksum="6CF137CC63166243" modified="2015-06-24" version="1" fragment="single">MAGTQDDGYDVAVVGAGAAGLACASDLARAGLRVRLVEAADTVGGRIRTDRVAGFTADRGFQVFNTSYPQVRRRLDLPALFLRPFTPGVLVHTDGGRLRLTDPTRRPRDGVALLRDGRVTPRDLLAFGVLSARAALAPASRLRSGPELTTRTALAGAGFSEEFVETFFRPFLSGVFLEDSLETSARFFHLVWRSMLRGTLCLPRDGIGAVPAQLAAGLRPGVLSTSSPVSGLTPEGIVLGGRELRARAVVVATGAGAAARLLPGLTPPAGRTVTTLYHAVERSPLPEPTLLVDAHRRFLNTCVLTEVQPGYSGDGRALVSTSVLGAPGPVEEAAVLGALAEAYGTDTGTWEPVHRVTVRGALPAMAPPLPLSRTTRFAPGRYVCGDHRATGSLQGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXG3</accession>
    <name>A0A0F4IXG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_29460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000910">
        <property type="protein sequence ID" value="KJY26697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26697">
        <property type="protein sequence ID" value="KJY26697"/>
        <property type="gene ID" value="VR44_29460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2258"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470360" evidence="2">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="283" mass="28067" checksum="3F55D8150D33125A" modified="2015-06-24" version="1">MSAHPSAVRLRRAAVIGALCAGIAVTGTGCAEKTDPDKGTNGVGKQTPEKIESQAKAAAAAANSVHLSGTLVSGGKSFTLDLRLKADGGSGEVKSQADTFQVLRVGEQLYLKASAAFWGKSDSAGKLGDKYVKVPESDPTYKQFRGFTDMHVLLDGLLGLQGKLTKGGYTTVGHTRAVPVSADAGKGGKLTVSLEERAGGAGRVELSEWGKAFPLEAPAQDQTVDYGSQLPTTKDGTGATGGTAGTGGGKGTGTGASPAPSKGAGTGGTGGSSSGQGSNPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXS4</accession>
    <name>A0A0F4IXS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001070">
        <property type="protein sequence ID" value="KJY25461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25461">
        <property type="protein sequence ID" value="KJY25461"/>
        <property type="gene ID" value="VR44_32440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3292"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="110" mass="11511" checksum="F68F9B39A7A30BE3" modified="2015-06-24" version="1" fragment="single">VNIYSLPVEAALTRHPAIARAVVVGRPSAVTGEEVCAFLVPAPGHTPSQAAAVEACDLVARDLAPAHRPTAVFWEPDIPLTDRGKPDKRLLRSRAEAGTPRPGAPPAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY23</accession>
    <name>A0A0F4IY23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000948">
        <property type="protein sequence ID" value="KJY26373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950804.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000948.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26373">
        <property type="protein sequence ID" value="KJY26373"/>
        <property type="gene ID" value="VR44_30235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="15"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="44936" checksum="8F3BB0A1134E3ADA" modified="2015-06-24" version="1" fragment="single">MSVTTRGPLPGGEYDVTVIGAGVVGSAIARELARLPLRAALVEASDDVGDGTSKANTAILHTGFDAVPGSLESRLVREGSRLLTAYAAESGIPVEPLGALLVAWDADQLDALPGLAAKAERNGHHHTRIIPAEEVRAREPHLGPGALGALEVPGESVICPWTTTLAYATQAVRAGVDLHLNCRVESAIPGDPHVVHTGRGPLRTRHLVNAAGLHADRIDRLLGHADFTVTPRRGQLIVFDELARDLVRHILLPVPTALGKGVLVTPTVHGKVMLGPTAEDLEDKTATGSTAEGLALLREKGRRILPALLDEEVTAVYAGLRAATGSEDYAIRAHPAQRYVTVGGIRSTGLTASMAIAAHVVELLAEGGLPVSGARDPEPVRMPNLGEAFPRPYRDAAMIAADPEYGRIVCHCERVTRGEIRDALAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY90</accession>
    <name>A0A0F4IY90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_31925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001041">
        <property type="protein sequence ID" value="KJY25646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951115.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25646">
        <property type="protein sequence ID" value="KJY25646"/>
        <property type="gene ID" value="VR44_31925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3100"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041116">
        <property type="entry name" value="SLATT_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18184">
        <property type="entry name" value="SLATT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_3" evidence="3">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="206" mass="22953" checksum="900BC4079FE66BAB" modified="2015-06-24" version="1" fragment="single">FIKSLAWRYAVHGAPFGSEVAGVEGVYRARLEKGLDELRKMGWRDPRTAGLVPEGGEITGAMQRLRGLEYQVRRETYVRDRLIEQRTWYQRRAEGSRRATALWAWTIVLLTCLGLVFALSGAFGSGPGATAAAGVTSAAAAAAIAWNEVRRHHPLIEAHTLIEQDLSAMMVVMQTTITESQWPSAVYETERYVSPQHTDWLARHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IYB6</accession>
    <name>A0A0F4IYB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_29525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000913">
        <property type="protein sequence ID" value="KJY26659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950676.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000913.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26659">
        <property type="protein sequence ID" value="KJY26659"/>
        <property type="gene ID" value="VR44_29525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2278"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="221"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="335" mass="34498" checksum="F022C0F5AE43074D" modified="2015-06-24" version="1" fragment="single">GSEPVLPDIDGLDGAGAWTSERATTADAVPGRLVVIGGGVVACEAATAWRSLGAEVTVLVRGRSLLSDWEPCAGEEVARGLTGLGAAVRFGVTALSLARDADTGEVSVETDDGGVLRCDELLVAVGRRPRTAGLGLEDVVPGYPASAADRLPVDDTGRVTSVPGGWLYAIGDVSGRAQLTHLAKYQARACAAALVERAAGRPAEGGPRQPWSAGAARTAAARAVFTLPELASVGLTERAARGAGFTVRTAEYRTDDVAGAALHADGYRGHAKLVVDADRRVVLGCTLTGPMATELIHTATVAIVGDVPLDRLWHAVPAFPTVGEVWLRLLEAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZA5</accession>
    <name>A0A0F4IZA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_28710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000881">
        <property type="protein sequence ID" value="KJY26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950527.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000881.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5494"/>
    <dbReference type="EnsemblBacteria" id="KJY26969">
        <property type="protein sequence ID" value="KJY26969"/>
        <property type="gene ID" value="VR44_28710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2074"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="298" mass="31138" checksum="07CD27383BB6F622" modified="2015-06-24" version="1">MSESSARLGVFKTYKLYVGGKFPRSESGRVYEVSDSKGNWLANAPLSSRKDARDAVVAARKAFGGWAGATAYNRGQILYRIAEMLEGRRDQFVREVGEAEGLSKSKAAAVVDAAIDRWVWYAGWTDKIGQVVGGANPVAGPFFNLSTPEPTGVVTVVAPQDSSFLGLVSVIAPVIATGNTAVVIASEKAPLPALSLGEVLATSDLPGGVVNILSGKAAEMGPHLAAHQDVNAIDLAGAGTALAKELEIAAADNLKRVLRPQPVDDWTADPGTSRMTAFLETKTVWHPTGSLGSGGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZF4</accession>
    <name>A0A0F4IZF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_28590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000878">
        <property type="protein sequence ID" value="KJY27019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27019">
        <property type="protein sequence ID" value="KJY27019"/>
        <property type="gene ID" value="VR44_28590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2047"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="284"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY27019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="552" mass="58951" checksum="703E50BE0CC1CF8B" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J023</accession>
    <name>A0A0F4J023_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="3" type="ORF">VR44_30470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000960">
        <property type="protein sequence ID" value="KJY26276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5351"/>
    <dbReference type="EnsemblBacteria" id="KJY26276">
        <property type="protein sequence ID" value="KJY26276"/>
        <property type="gene ID" value="VR44_30470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2508"/>
    <dbReference type="eggNOG" id="ENOG5032TBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="10540" checksum="552DC9588619DAA0" modified="2015-06-24" version="1">MGEAERGESAPRLRISFWCSNGHETQPSFASDAQVPDTWDCPRCGFPAGQDRDNPPAPPRTEPYKTHLAYVRERRTDADGEAILAEALAKLRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1V9</accession>
    <name>A0A0F4J1V9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">VR44_26975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="JZWV01000805">
        <property type="protein sequence ID" value="KJY27713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950211.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000805.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5233"/>
    <dbReference type="EnsemblBacteria" id="KJY27713">
        <property type="protein sequence ID" value="KJY27713"/>
        <property type="gene ID" value="VR44_26975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1557"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="269" mass="28405" checksum="FA12B35A94F3D325" modified="2015-06-24" version="1">MSVLDEIIEGVREDLAERQARVSLDELKERAAKAPQAKDGVAALRGDGVKVICEVKRSSPSKGALAAIADPAGLAADYEAGGAAVISVLTEQRRFGGSLADLEAVRARVDIPILRKDFIVTAYQLWEARAYGADLVLLIVAALDQEALVSLIERAESIGLTPLVEVHDEEEIERAVAAGAKIIGVNARNLKDLKVDRSTFERVVGEIPPHIVKVAESGIRGPHDLIAYANEGADAVLVGESLVTGRDPKAAVADLVAAGAHPALRHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J263</accession>
    <name>A0A0F4J263_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_28620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000879">
        <property type="protein sequence ID" value="KJY26996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950508.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000879.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26996">
        <property type="protein sequence ID" value="KJY26996"/>
        <property type="gene ID" value="VR44_28620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2053"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY26996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="37070" checksum="BC7025074E82CF63" modified="2015-06-24" version="1">MSDLATTTSPELDAAMERHRVELTGYCYRMLGSSFDAEDAVQDTYVRAWRAYGKFEGRSSLRSWLYRIATNVCLDLLNAGNKRARPMDLTAPQHQASAVLNERPEVTWLEPVPDGRVLPQTADPAEMALAKESVRLAFVAALQHLPPKQRAVLILREVLAWKADEVAQLLETTVASVNSALQRARATLSGQALRPSDPADPLDAEQAKLLEQYLSAFEAYDITRLTALLHEDAVLSMPPFDLWLRGPEDIAAWHLNQGIGCKGSRLIPTTANGLPAFGQYRPREDGRPGHVPWALQVLEVSEGRIVGLNAFLDTARWFPLFGLPEELDEAHEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J280</accession>
    <name>A0A0F4J280_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000791">
        <property type="protein sequence ID" value="KJY27858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950138.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000791.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000012_gene1168"/>
    <dbReference type="EnsemblBacteria" id="KJY27858">
        <property type="protein sequence ID" value="KJY27858"/>
        <property type="gene ID" value="VR44_26595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1444"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="23060" checksum="039A827EBCF4816A" modified="2015-06-24" version="1">MSPRSASVNEELRRRSRERLLQATVELVAERGYEATKLGDIADRAGAARGLVSYYFPGKRQLLQSAVHRLMHLTLEEALEREPRTDDGRERLARAVDAILGLARDQPRLMRTHMAGILQAEGFIQCPEQQRLAQLLRDTVTRYGSADVDTDYPMLRALLMGAVVAVLLPGAPMPASRLRAELFQRYGLEWERGFPPDGGPPGGTFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2C2</accession>
    <name>A0A0F4J2C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_26285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000773">
        <property type="protein sequence ID" value="KJY28004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28004">
        <property type="protein sequence ID" value="KJY28004"/>
        <property type="gene ID" value="VR44_26285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1415"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Docking" evidence="2">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12926" checksum="45C5C3E6B27BF499" modified="2015-06-24" version="1" fragment="single">MADTEEKLRSYLRKATADLQETRRRLREAEAAAGEPVAIVGMGCRFPGGVTSPEELWELVSRGGDGMSAFPADRGWDVGAAYSPTGHDPVGGFLYDADRFDADFFGISPREAQAMDPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J334</accession>
    <name>A0A0F4J334_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_25750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000746">
        <property type="protein sequence ID" value="KJY28274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949979.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000746.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28274">
        <property type="protein sequence ID" value="KJY28274"/>
        <property type="gene ID" value="VR44_25750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1255"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20592" checksum="EEBBE44905B3AD3C" modified="2015-06-24" version="1">MNRYETTGHLLLTPVDREAPARVVRLREMNLGERVEAELDAFARRVAQTLDAPYAGVNFVGEERQFFAGLHHGPDAAASGYPARVLPRDHGYCPHVVVRRRALVLEDVRDFARFAGNAVVDESGIRSYLGAPLTDRRGIVLGTVLAAVLGTVCAADVVPRRWGLAGLTTVKALAAELTELLQQRGDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3H6</accession>
    <name>A0A0F4J3H6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_25455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000735">
        <property type="protein sequence ID" value="KJY28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949925.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000735.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28404">
        <property type="protein sequence ID" value="KJY28404"/>
        <property type="gene ID" value="VR44_25455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1187"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470357" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="58"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="379" mass="38926" checksum="9C4B8172E4C694FD" modified="2015-06-24" version="1">MKLQRKNRLRASALGALVVSGALVLTACGSDDNTKTGADGTPKASAPAPGDIKCDGAKGKLLASGSSAQKNAVDLWVKNYMAACSGVEVNYKSSSSGEGIVAFNQGTVGFAGSDSALKPEQVEDSKKVCTGGQGINLPMVGGPIALGFNVAGVDKLNLDAATIANIFNDKIKKWDDDAIKKLNPGVNLPPTAIQAFHRSEDSGTTENLGKYLKAAAPDAWSYDASKKWPAPGGQAASGSAGVASQVKAVDGAIGYFELSYATSQNIKTVDVNTGASAPVKATPENASKAISAAKITGTGSDLALKLDYATKAEGAYPIVLVTYEVVCDKGNKPETLGTVKSFLEYTASDAGQKALTENGYAPIPTEINSKVREVIKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3T1</accession>
    <name>A0A0F4J3T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_24005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000685">
        <property type="protein sequence ID" value="KJY28997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949655.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000685.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28997">
        <property type="protein sequence ID" value="KJY28997"/>
        <property type="gene ID" value="VR44_24005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.779"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="9">
        <location>
            <begin position="271"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY28997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="403" mass="43065" checksum="EB149D37F12F84C2" modified="2015-06-24" version="1">MSEDLWPPHALEHPEVDTPPVSSGPGGVTLIIPTFNESANVAELLRQLRACLPAHPPCEVLFVDDSTDDTPALIEKAAADCPFPVAVLHRDSPAGGLGGAVVEGIARAGSDWIVVMDADLQHPPHLVPELVGEGERSGADLVVASRYLPGGSRAGLAGGYRVAVSRGATWLAKGLFPRALRGISDPMSGFFAMRRSAVTGAVTGGALKPLGYKILLELAVRCGPAKTAEVPFVFQDRFAGESKSTAREGLRFLTHLAALRSASPLARMIGFGLIGLSGFVPNLLALWLLTHAGMQYLAAEVVANQAGVLWNFLLIETLLFRDRRRHRHWADRVGRFALLANADLLLRIPLIALFVDRFGLGVLPATALALVTTFVLRFVATEALVYLPRGPRAAARNRPTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3U8</accession>
    <name>A0A0F4J3U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_23965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000684">
        <property type="protein sequence ID" value="KJY29012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949648.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000684.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29012">
        <property type="protein sequence ID" value="KJY29012"/>
        <property type="gene ID" value="VR44_23965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.769"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY29012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="28857" checksum="91395DF1F63001C6" modified="2015-06-24" version="1">MTGRPVELVVEGLRYEVDGRTLLDGIGLTARPGETVGVVGPNGSGKTTLLRCVYGTLRPAAGRVLIDGADASALGVKERARRVAVVPQDAAGTFGLTVREVVSMGRSPHKRFWEQDGPDDRLRVARALETVGVSALAGRRFDGLSGGERQRALVARALVQEPGLLALDEPTNHLDIRYQLEVLGLVRRLPVTGLLVLHDLNLAASFCDRLYVLSGGRVVARGRPEQVLTEELLAEVYGVSARVAVHPETGAPNIVYLPERSAGVTPAAGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3V6</accession>
    <name>A0A0F4J3V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000723">
        <property type="protein sequence ID" value="KJY28519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949873.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000723.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28519">
        <property type="protein sequence ID" value="KJY28519"/>
        <property type="gene ID" value="VR44_25165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1125"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="29147" checksum="B6CB3A72D819E9FB" modified="2015-06-24" version="1">MTHSSSQNEQPHPAALPPFQTLLNNTNWGALDTAFGTGEDLPAALTLLTDPDPVIREAALQAALGPGTHQNSIYEATVPVALFVAAILNHPAITAGDDNPGIGTQHRPTLVQLLDWLGDTAYDADDECVAAGERVFDGGFLDEYDAMRAFRDARPAIFSAVRPLLGHDDANVRHTALVTAIPLIEHPFLTQYQADLVDHARRLLAISTDRHHRDRVLETLKAWGHDTSGLENASDIAAREHYAHLRAARASWDDNWTGSGSYSDDPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4S4</accession>
    <name>A0A0F4J4S4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">VR44_23435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949551.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5190"/>
    <dbReference type="EnsemblBacteria" id="KJY29250">
        <property type="protein sequence ID" value="KJY29250"/>
        <property type="gene ID" value="VR44_23435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.629"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="205" mass="23035" checksum="56AAD1A9A12EE271" modified="2015-06-24" version="1">MAGAMRKMAVYLGLVEDDRYDNPGYDPDDEFEPEPEPERPRERERRQQPVHQSPVTDEPVRAVQPPAPREPLPIPSENGRPARIAPVASITPDRTNLEKNAPVIMPKVVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4V4</accession>
    <name>A0A0F4J4V4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000698">
        <property type="protein sequence ID" value="KJY28849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949728.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28849">
        <property type="protein sequence ID" value="KJY28849"/>
        <property type="gene ID" value="VR44_24375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.860"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="37"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="195" mass="21732" checksum="1DFB8100C8ACC8D0" modified="2015-06-24" version="1">MDPRIPRLRRKLAAIPFQPLRSHSFGEEKHEFRLGPKLAEARVAAFEADQDIALPDAYRQFLTQIGGSGAAPFYGLMPLERCSLRVMKPRGEPGKPRGFDGRNPRGHGGDLFLHIIEMGCTDLCVIGVTGPLTGRILVGNGDGYWGPNVSSATDFLDWYERWLNHMSAGRDNRALELTSPRLLAHPNRHRLAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J602</accession>
    <name>A0A0F4J602_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_22480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000629">
        <property type="protein sequence ID" value="KJY29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29620">
        <property type="protein sequence ID" value="KJY29620"/>
        <property type="gene ID" value="VR44_22480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="132" mass="14606" checksum="F662E5B8AF30C7B1" modified="2015-06-24" version="1" fragment="single">MTSHTTPGRPTAPAGAARRRLIRELLLVAGLFAVYKAGRMLSTGRTEEAHHNAVRVWDAERALHLPGEGAVQRLLLHSDTVVHAANTYYAAVHFPATVLFLVWLYLRRPGHYLWTRRVLAVLTGAALALHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6B7</accession>
    <name>A0A0F4J6B7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HEPN_SAV_6107 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000620">
        <property type="protein sequence ID" value="KJY29745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949323.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000620.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29745">
        <property type="protein sequence ID" value="KJY29745"/>
        <property type="gene ID" value="VR44_22180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.320"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040891">
        <property type="entry name" value="HEPN_SAV_6107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18726">
        <property type="entry name" value="HEPN_SAV_6107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV_6107" evidence="2">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17506" checksum="211309A1C09C97E8" modified="2015-06-24" version="1">MATPSPSPVHPVPRRSAAPPAALDLLAKARSGLAEAALLPRPNERYATAHLAALRAAAAVLAARARPEPVNPRRRPRIRSAWEVLPEIAPELTEWSALFASGAARRARAEAGIPDAATGRDADDLVREAGMFLRLVERMLALRPVAQPLPQPRPERPERPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7A6</accession>
    <name>A0A0F4J7A6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_22405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000627">
        <property type="protein sequence ID" value="KJY29653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949362.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000627.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29653">
        <property type="protein sequence ID" value="KJY29653"/>
        <property type="gene ID" value="VR44_22405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.370"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470206" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="8">
        <location>
            <begin position="71"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="197"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY29653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="542" mass="57349" checksum="961179AFC2606D0F" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7N1</accession>
    <name>A0A0F4J7N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949101.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30205">
        <property type="protein sequence ID" value="KJY30205"/>
        <property type="gene ID" value="VR44_21010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8933"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisom_I" evidence="2">
        <location>
            <begin position="81"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="38504" checksum="2015FB23BBA2C153" modified="2015-06-24" version="1">MRLRTSRPDRPGCTRVRHGRGFRYLDARGRPVTDPAERARIRALVIPPAWRDVWICPWPTGHIQAMGTDAAGRRQYLYHQRFRDRQEAAKHEHVLDVATRLPRLREAVAEDLTARGLARDRVLACTARLLDLGFFRVGGTGYRKDNGAYGLTTLLPEHALCSRGEVCFSYPGKSGQDQTRALVDPAAYQVVRALLRHSTDGRQLFVYRQGRRWHDVHADDLNDYLRDRSGTDITAKDFRTWHATVLAAVALAVSVEVAGDSRARRARAMSRAVREVSDYLGNTPAVCRASYINPRLFELYEEGITVRPALDALGKGVAYGEPATHGAVEAAVLRLLSERDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7Y1</accession>
    <name>A0A0F4J7Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000574">
        <property type="protein sequence ID" value="KJY30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30310">
        <property type="protein sequence ID" value="KJY30310"/>
        <property type="gene ID" value="VR44_20810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8881"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="14207" checksum="70F1B30A0288BF2E" modified="2015-06-24" version="1">MRIGDIVRAGALTPQQAKEKSDRDFAEHLPQGYLTPGHAFYALEAGGEVVGSGWVNHGFLPGVTFGFSLEVYEEHRGRGYGRAAMAVGEWAAREGGDEVLMFNVFGGNEVAMSLYDSTGFTVVEEFRSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8C9</accession>
    <name>A0A0F4J8C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_21470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000600">
        <property type="protein sequence ID" value="KJY30003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30003">
        <property type="protein sequence ID" value="KJY30003"/>
        <property type="gene ID" value="VR44_21470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY30003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="133" mass="15007" checksum="E7098A4C9C272149" modified="2015-06-24" version="1" fragment="single">MTPALPTHARTAERRTSRPTAGSEEAVTRLALDARDGDPVKADRFVRALHRDVWRYVAYLSADTQAADDLTQDVFLRALAALPRFEGRSSARTWLLSIARRTVVDSIRRAAARPRLSDRQDWQTAAERTQPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8I5</accession>
    <name>A0A0F4J8I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_20290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000560">
        <property type="protein sequence ID" value="KJY30500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30500">
        <property type="protein sequence ID" value="KJY30500"/>
        <property type="gene ID" value="VR44_20290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY30500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="260" mass="26816" checksum="57E7DE36091B7BFB" modified="2015-06-24" version="1">MWGESSVGADLAARPDLSRRLAELSARVGAPLLVNVDARRSDRPGIYKSSVLVGPRGLTGDRYDKMRLVPFGEYIPARPLLGRAPSVGKAAGEDRMRGAAPVIMDLPGGARIGPLVCFESAFPDMSRHLAEEGAGVLVAQSSTSTFQDSWAPAQHASLAALRAAETGRPVVHATLTGVSAVFGPSGERVGAGLPTSARTAAVYEVPLARGTTLFVRFGNWPGGAALAALALYCAARGARAVRAARSAPAPSAPPARTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8S7</accession>
    <name>A0A0F4J8S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_20045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="JZWV01000553">
        <property type="protein sequence ID" value="KJY30590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948926.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000553.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1605"/>
    <dbReference type="EnsemblBacteria" id="KJY30590">
        <property type="protein sequence ID" value="KJY30590"/>
        <property type="gene ID" value="VR44_20045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8631"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="391" mass="41469" checksum="CDD52FECA904484F" modified="2015-06-24" version="1">MTSTGKEPVAVVGVGQTKHVAARHDVSLAGLVREAAVRALADAELTWADIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAARVHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDTVGSLVAYKDRRNALKNPYAHLHEHGITLEKVQSSPMLWDPIRYSETCPSSDGACAMVLTDRAGAARSPRPPAWVHGGAMRSEPTLFAGKDFVSPQAGKDCAADVYRQAGITDPRREIDAVEMYVPFSWYEPMWLENLGFAQEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMIRFAEAALQVRGLAGEHQVPGARRAMGHAYGGGAQFFAMWLVGAGQPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J970</accession>
    <name>A0A0F4J970_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000542">
        <property type="protein sequence ID" value="KJY30735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948843.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000542.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30735">
        <property type="protein sequence ID" value="KJY30735"/>
        <property type="gene ID" value="VR44_19590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8529"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="157" mass="16478" checksum="3059667FD5D1F3B7" modified="2015-06-24" version="1">MSRVQLALRVADLEASIAFYSKLFGAEPAKRREGYANFAITEPPLKLVLIEGESGEDTRLDHLGVEVASTEDVNAATTRLKDAGLATFEENDTSCCYALQDKVWVTGPGKEPWEVYVVKADADQLGKSAVAGGDACCSGQEESTAAVPAASGCACGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9H4</accession>
    <name>A0A0F4J9H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6645"/>
    <dbReference type="EnsemblBacteria" id="KJY30439">
        <property type="protein sequence ID" value="KJY30439"/>
        <property type="gene ID" value="VR44_20445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8799"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="25256" checksum="2EB44C27B294881D" modified="2015-06-24" version="1" fragment="single">MDAFYASVEQASKPSLRGKAVIVGGLGPRGVVATASYEARRFGVHSAMPTAQARRLCPNGAYLIPRFTLYREVSEVVMGLLRELSPLVEPLSLDEAFVDLEAGGTAFDSASARATGERLRADITAATGLSGSVGLAGSKMLAKVASEEAKPDGLLLIEPGTERELLAPMSVRTLPGVGPATGEHLRRAGITTVGELAEAGEDELVRMVGRAHGVGLYRMALGLDDRPVVAERDAKSVSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9X6</accession>
    <name>A0A0F4J9X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_18720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000512">
        <property type="protein sequence ID" value="KJY31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948681.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000512.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31172">
        <property type="protein sequence ID" value="KJY31172"/>
        <property type="gene ID" value="VR44_18720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8355"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="410" mass="42923" checksum="E2417278736F6603" modified="2015-06-24" version="1">MTDVPANRVVITGLGAVSSIGLGASEFLSGLRSGRSAAKPITAFDTEGFDHANGCEIVDFDPTHWIKNLEPETLGRASQFSVTAARMALEDAALAEADLRAGRCLISIGTTDGESRDLDQLVETEVRRGAEHMDPTVTARVPAGRLSAAIAHEFGLSRVEAVTLPTACAAGNYAIGYGFDAVRTGEVDHALVGGADALCRKTFTGFYRLGTIAPERCQPFDIDRKGILTGEGAGVLLLESLDSALARGARIHAEVLGYGLNCDAHHPVAPNQDSVAQCMRLALDAAGVGPEDVDFISAHGTGTKANDVTEARAIRQVFGDRTPRTVSIKSMLGHSMGAASALASIGCALALTEGFIPPTINHVETDPECSVDCVPNHAVDAELRVVQNNGLAFGGNNSVVIFGKYEEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAB4</accession>
    <name>A0A0F4JAB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_19870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000547">
        <property type="protein sequence ID" value="KJY30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30688">
        <property type="protein sequence ID" value="KJY30688"/>
        <property type="gene ID" value="VR44_19870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8593"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY30688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="270" mass="28235" checksum="914880CF2B6B103F" modified="2015-06-24" version="1" fragment="single">GGWTWSGGFGQAAQNPAAFAQSCYDLVEDPRWADVFDGIDIDWEYPNACGLSCDTSGAAAFKNLMSALRAKFGSANLVTAAISADGSNGGKLDLADYAGAAPYVDFYNVMTYDFFGAWDAKGPTAPHSPLTSYTGIPIAGFNSEAAITKLKGKGIPGSKLNLGIGFYGRGWTGVTQDAPGGTATGPAPGTYEQGIEDYKVLKTSCPTTGTVAGTAYARCGSNWWSYDTPATIAGKMTWLKNQGLKGAFFWEFSGDTTNGELANAIHTGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCI3</accession>
    <name>A0A0F4JCI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">VR44_19785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000546">
        <property type="protein sequence ID" value="KJY30696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007266580.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000546.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3121"/>
    <dbReference type="EnsemblBacteria" id="KJY30696">
        <property type="protein sequence ID" value="KJY30696"/>
        <property type="gene ID" value="VR44_19785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8576"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="7945" checksum="1A27465959D601B0" modified="2015-06-24" version="1">MKRDVHPEYVETQVSCTCGASFTTRSTLTEGTIRAEVCSECHPFYTGKQKILDTGGRVARFEARFGKGAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCQ2</accession>
    <name>A0A0F4JCQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000450">
        <property type="protein sequence ID" value="KJY31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948366.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000450.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31970">
        <property type="protein sequence ID" value="KJY31970"/>
        <property type="gene ID" value="VR44_17060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7943"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="21311" checksum="63FF145B4F51D6AF" modified="2015-06-24" version="1">MGGVFEPLEGGGAAVALDEIEISILRSLAVQLLELIGPGEPEPAEDADPLAVLFAAEGPTEPPSDPALARLFPDAYGGPGAGSGEDPEELRARSAEFRRFTENDLRTRKREDALAVVRSLDALTPAGDGAAVLELAGELPLRWLGALNDLRLTIAARLEITEDEQSGELYRLPDDDPRKPMVMAYLWLGGLQETLIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCU7</accession>
    <name>A0A0F4JCU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_19485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948826.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30806">
        <property type="protein sequence ID" value="KJY30806"/>
        <property type="gene ID" value="VR44_19485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8506"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="397" mass="42244" checksum="2B92B44C4DCC25F5" modified="2015-06-24" version="1">MTSDRARYDRATARLDAPLAIVDLDAFDANADDLVRRAGGKPVRVASKSVRCRALLERVLARPGFAGIMSYTLAESLWLARSGFEDVLLAYPSADRAAFGELAGDPKLAAAVTVMVDDPAQLDLIERSRAGGAEEIRVCLELDTSLRLFGGRVRVGARRSPLREPGQLAELARAVASRPGFRVVGLMAYEGHVAGVGDAVAGRPVRSRMIRLMQGAARRELAARRGEVVRAVRSVVPDLEFVNGGGTGSVAETAAEEAVTEVAAGSGLYVPRLFDNYTSFRGRPAALFAQPVVRRPGVGVVTVLGGGYPASGAAGADRLPVPYLPAGLRYDPQEGAGEVQTPLLGSPADDLLIGDRVWFRHAKAGELCERFDTLHLVEGDRVTASVPTYRGEGRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JF93</accession>
    <name>A0A0F4JF93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purU</name>
        <name evidence="5" type="ORF">VR44_15905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000410">
        <property type="protein sequence ID" value="KJY32464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948147.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000410.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7329"/>
    <dbReference type="EnsemblBacteria" id="KJY32464">
        <property type="protein sequence ID" value="KJY32464"/>
        <property type="gene ID" value="VR44_15905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7590"/>
    <dbReference type="eggNOG" id="COG0788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY32464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="292" mass="32523" checksum="140B48DEAAB2AD73" modified="2015-06-24" version="1">MSDPQPGARPLPQYVLTVSCPDKQGIVHAVSSYLFMTGCNIVDSQQFGDRETGLFFMRVHFEAEPEVTLDKLRASFAAIGDSFRMDWQIHRSDERMRIVLMVSKFGHCLNDLLFRTSIGALPVEIVAVVSNHTDFAELVASYDIPFVHIPVTKDTKAAAEAQLLELVRAENVELVVLARYMQVLSDTLCKELSGRIINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVERVGHEVTPDQLVAIGRDVECQALARAVKWHSEHRVLLNGSRTVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFM7</accession>
    <name>A0A0F4JFM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000466">
        <property type="protein sequence ID" value="KJY31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31791">
        <property type="protein sequence ID" value="KJY31791"/>
        <property type="gene ID" value="VR44_17460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8029"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="78" mass="8464" checksum="AB8B162624753976" modified="2015-06-24" version="1" fragment="single">VTAMVEGGGVAVTRRTDLAQRLNKAKDGSITPASYSSHWPSRERLFTDVILFLDWKGDGKGPQRLHFAPSPSLPGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JGK3</accession>
    <name>A0A0F4JGK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947970.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32898">
        <property type="protein sequence ID" value="KJY32898"/>
        <property type="gene ID" value="VR44_14955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7407"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="245" mass="25401" checksum="447C1A96E0571191" modified="2015-06-24" version="1">MNTPTTKVIAVTGASSGIGEATARRLAADGHSLLLGARRTGRLEALAAEIAALGGTAAARRLDVTDAADVQAFVRAARDLYGRVDVLVNNAGIMPLSPLEEARTQEWDRMIDVNLRGVLHGIAAALPVMRDQGGGHIVNVASVGAYEVTPTAAVYCATKFAVRAISEGLRKESGGDIRVTVVSPGVTVSELADHITDAAAREAMRSYRKVAIPAGAIADAIAYAVSQPPEVDVNEIVVRPSASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JH83</accession>
    <name>A0A0F4JH83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_14550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000374">
        <property type="protein sequence ID" value="KJY33113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947900.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000374.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33113">
        <property type="protein sequence ID" value="KJY33113"/>
        <property type="gene ID" value="VR44_14550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7166"/>
    <dbReference type="eggNOG" id="ENOG502ZHMF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6398" checksum="28183852F78FF945" modified="2015-06-24" version="1">MADIARQGRKLFAFNGHESGTRHPLVAAAMVLPLAALLLFLFGGFDQVAAQASSVGVMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHD0</accession>
    <name>A0A0F4JHD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000350">
        <property type="protein sequence ID" value="KJY33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947741.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33600">
        <property type="protein sequence ID" value="KJY33600"/>
        <property type="gene ID" value="VR44_13655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7007"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="130" mass="14772" checksum="82674DA38BBFE134" modified="2015-06-24" version="1">MVTKQLKGSGTAKDEADVTRADSLAREIFSDIANKWALLIIEAVGDRTLRFTELRDEVEGISHKMLTQNLRLLERNGLIDRTVHPTVPPRVEYTLTEPGQALRAVVDGMCDWTHRYLADLETARHRFDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHL3</accession>
    <name>A0A0F4JHL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="14" type="ORF">VR44_14270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000368">
        <property type="protein sequence ID" value="KJY33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947852.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3349"/>
    <dbReference type="EnsemblBacteria" id="KJY33253">
        <property type="protein sequence ID" value="KJY33253"/>
        <property type="gene ID" value="VR44_14270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7201"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="1"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="889" mass="95198" checksum="C03D15976454D8D8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHR8</accession>
    <name>A0A0F4JHR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_14090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000362">
        <property type="protein sequence ID" value="KJY33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947823.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000362.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33359">
        <property type="protein sequence ID" value="KJY33359"/>
        <property type="gene ID" value="VR44_14090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7131"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="338" mass="36527" checksum="8560D52DB02D1F99" modified="2015-06-24" version="1">MTFLITGGAGYIGAHVVRAMLLAGQKVVVFDDLSTGREDRVPEGVPLVTASVLDRLALDEAIAKHKITGVVHLAGKKQVGESVEKPLYYYHENVEGLQVLLGAVARAGIRNFLFSSSASVYGMPDVDSVTEETPCKPLSPYGETKLAGEWLVRAAGRAHGISTACLRYFNVAGAATPELADTGVFNLVPMVFERYDAGEGARIFGDDYPTPDGTCIRDYIHVEDLADAHVVAARRLAEWGAEGEYKDLTVNIGRGEGVSVKEMVELLNEGTGHTYAPVVTPRRPGDPAKVVASADRIAAELGWKAKHDVREMISSAWAGWEANRRAPHHDRRQDAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI89</accession>
    <name>A0A0F4JI89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948056.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32686">
        <property type="protein sequence ID" value="KJY32686"/>
        <property type="gene ID" value="VR44_15430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7487"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="168" mass="18018" checksum="3FF9D976B39B4D07" modified="2015-06-24" version="1">MGMSVTISAAAAEDAEQIFKLQYLAFQREAELYGNYLIQPLTQSLDSLKQELATDTVLVARLGDEVVGTVRGSVGEDGTASIAKLCVHPRLQGHGLGARLLRAVEEALAGHGGTTRFRLHTGHKSESNLRLYRKAGYAKVGNRTASDGVHLVILEKDAEVPADYTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIX4</accession>
    <name>A0A0F4JIX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_13410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000341">
        <property type="protein sequence ID" value="KJY33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947697.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000341.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33759">
        <property type="protein sequence ID" value="KJY33759"/>
        <property type="gene ID" value="VR44_13410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6918"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="508" mass="54655" checksum="B7F7128C8D90A5C8" modified="2015-06-24" version="1" fragment="single">MQMDDLARLAAHHGVASSYQPAEDVTVQVPPATVRAVLGLIGVPADTPEAVRQLADSAEREAAGRLLPPTLVQWRGEPAPAALTGLPPGTRLRVTLEDGAGEAAWDARLPLGVHRLTAETPDGRTAAPERAHGLLVQLYSLLSERSWGMGDLGDLAELARWAARTHGAGFIQVNPLHAAVPGTPTDPSPYRPASRRFPDPVYLRVEDLPEWEACPDRAALAELARRGGELRREVLEKGALIDRDAVWALKRAALELLYSVPRTPAREAAYRAYRAAQGQGLDLHAAWCAAAAGEDPGARADFHAWLVWLTDTQLTAAQRAAREAGMEVGIVHDLAVGVHPEGSDARFGPFHARHVSVGAPPDAFNARGQDWGLPPWRPDALEGSAYAPFRALLRGVFRYAGAVRVDHVMGLFRLWWIPQGTPPAEGTYVSYDGEAMLAVLVLEAHRAGAVVVGEDLGTVEPRVRGALARRGILGTSVLWFERDWSGDGQPLAPGAWRSDCLATVTTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJV8</accession>
    <name>A0A0F4JJV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000313">
        <property type="protein sequence ID" value="KJY34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947547.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34099">
        <property type="protein sequence ID" value="KJY34099"/>
        <property type="gene ID" value="VR44_12615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6589"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471116" evidence="2">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="171" mass="18773" checksum="DA72B1C1BB506C60" modified="2015-06-24" version="1">MPKPTRTILALAAGSLALGLVGGGAAVADQGPAAQGAARYHAPGDGRDDYDDPSYDEDGHHKHRYSLGKVVSRGPLSVRSKPTTHSHLQYKVYPHETLALKCKTRGENVAGNDLWYLIDPGDDDRGDDWSDGNDGEGRKKARGTRDRDGYDNDWVSARYVKDLKPVRWCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLG8</accession>
    <name>A0A0F4JLG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000336">
        <property type="protein sequence ID" value="KJY33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947652.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000336.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33811">
        <property type="protein sequence ID" value="KJY33811"/>
        <property type="gene ID" value="VR44_13165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6851"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="250" mass="26235" checksum="7DAC52C583727FDB" modified="2015-06-24" version="1">MVAPPDSAPPDDDVLWARSLHYSHSGSPGLIGVGAAVRQGEILAVTGPRGSGKTTLLRCLAGRLVPDQGEVRFDGIAVHTLGALARERLFRARFAWIGPEPQLLPELKVWENAALPLLLTGAPHRAARAAAHEWLERLDIGGFAGKRPGALNRAESQRVALARALAGEPAVLFADEPTAPLHRAERALLLRTLTTAARSHAITVVLATHDEETAAAADRDLALLDGRPADAAAVVSPGTTEDQAACSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLJ6</accession>
    <name>A0A0F4JLJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS fructose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VR44_10935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000245">
        <property type="protein sequence ID" value="KJY35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35055">
        <property type="protein sequence ID" value="KJY35055"/>
        <property type="gene ID" value="VR44_10935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6067"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="13">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="14">
        <location>
            <begin position="137"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="12">
        <location>
            <begin position="528"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="674" mass="69089" checksum="962638C61F62F6A7" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JN34</accession>
    <name>A0A0F4JN34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000234">
        <property type="protein sequence ID" value="KJY35239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35239">
        <property type="protein sequence ID" value="KJY35239"/>
        <property type="gene ID" value="VR44_10530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5849"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="26" mass="2902" checksum="417802C5860EF859" modified="2015-06-24" version="1" fragment="single">TAQQQRQLASAVKNAREMALLPYGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP42</accession>
    <name>A0A0F4JP42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000188">
        <property type="protein sequence ID" value="KJY35940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946855.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000188.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35940">
        <property type="protein sequence ID" value="KJY35940"/>
        <property type="gene ID" value="VR44_08880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="496" mass="53940" checksum="5588699F79C3A527" modified="2015-06-24" version="1" fragment="single">AADATAHMVENPHLTSTLHGHEVLITLILIALLGGVFLKGFSEAIGVAVVLVSTYLALNVVVVAVGLWNVFTEPQVVTDWTSALTAEHGNVFMMIAIALVVFPKLALGLSGFETGVAVMPHVQGDPSDTEEKPAGRIRGAKKLLTTAAVIMSVFLICSSLVTTLLIPAAKFQPGGEANGRALAYLAHEYLGSAFGTVYDVSTICILWFAGASAMAGLLNLMPRYLPRYGKALHWARALRPMVIVFTLIAFLVTWLFNADVDAQGGAYATGVLVLITSAAVAVTIAARRAGERGWTIGFGIISAVFIYTTAINVAERPDGVKIGACFIGGIMALSLLSRLARVFELRVTHIEFDDMAERFIRDTANRTIRFIANEPDSRDLEEYRQKKAQIRADNDIPAEDDVMFVEVTVLDASEFESGMRVRGEVLHGRYRVLTLESSSIPNALAALLLHVRDETGQRPHIYFEWTEGNPMANFFRFFLFGQGEVAPVTREVIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPZ7</accession>
    <name>A0A0F4JPZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947248.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34991">
        <property type="protein sequence ID" value="KJY34991"/>
        <property type="gene ID" value="VR44_11020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6088"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471134" evidence="2">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="32499" checksum="EE4D14FBA5F0FD48" modified="2015-06-24" version="1">MNTGVKITAFAAALAAAFGAAYGVGAGVGPVGAPARTEHASHATQAKAPAAEGGHGGHGQATAQGPAAGGLQVSDAGYTLSLDTPQVAPGQSELRFSVKDAAGRKVTGYKTEHGKELHFIVASRDLTVFRHLHPVRAEDGTWSTPVDLPAAGAYKAFADFAPSAGDAKNVTLGADLTVPGAYAPNPMPPVAPTAEVDGYQVSLAGTLDPGKPGELKLGVSKDGKPVTDLEPYLGAYGHLVALRDGDLAYLHVHPNEGGPGPDVSFTATAPSAGTYRLFLDFQHQGKVRTAAFTVRAGDGQAAAAPAAQPAQPAGEEQGGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQE1</accession>
    <name>A0A0F4JQE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_08720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946822.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36064">
        <property type="protein sequence ID" value="KJY36064"/>
        <property type="gene ID" value="VR44_08720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4987"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY36064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="235" mass="25165" checksum="BC3CF92788B42E07" modified="2015-06-24" version="1">MTGSGVTSPATEPIRVFLLDDHEVVRRGVHDLLDAEPDLSVVGEAGTAEQALARVPALRPQVAILDVRLPDGDGVSVCRELRSRMPALACLMLTSFDDEEALLDAVMAGASGYVLKQITGTDLVTAVRTVASGRSMLDPGATTRLMARVRGDVPPEERVPGLPGFTDREKEILLMVSEGLTNREIGKRLYLAEKTVKNTISRLFVKLGVEGRVQAAVIASHALTPPGRHPVPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQF1</accession>
    <name>A0A0F4JQF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">VR44_07705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946633.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36587">
        <property type="protein sequence ID" value="KJY36587"/>
        <property type="gene ID" value="VR44_07705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4153"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY36587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17931" checksum="AB1050102AD7402C" modified="2015-06-24" version="1">MTQTSESVTWLTQAAYDQLKAELDYLSGPARTEIAMKIAAAREEGDLRENGGYHAAKEEQGKQELRVRQLTQLLENAKVGTAPTTAEGEVAPGMLVTIAFDGDEDDTLEFLLASREYASSDFETYSPQSPLGAGVLGKKVGEDAQYELPNGKKATVKVMAVKPFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRR2</accession>
    <name>A0A0F4JRR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor sulfurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_08080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000161">
        <property type="protein sequence ID" value="KJY36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946705.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000161.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36433">
        <property type="protein sequence ID" value="KJY36433"/>
        <property type="gene ID" value="VR44_08080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4443"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014308">
        <property type="entry name" value="Xanthine_DH_XdhC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02964">
        <property type="entry name" value="xanthine_xdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="112"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="272" mass="28689" checksum="33AE987A5A5AA695" modified="2015-06-24" version="1">MPDLTWVAAVARLRARREPGALVTVATVRGHAPRKAGAKLVVGRTETWGSVGGGNIEAVAIDRARELIATPGAEPELMEFALNDKVTGRHGVQCCGGAVSVLLEPLPVVPAVAVFGVGHVGLELARILARFDLDLHLTDTRPGQLTDERLAVLGDAVAQVHVHHTPLLPEEVLAELAPGTHVLIMTHDHAEDAALCDAALRTPGLGTIGLIGSAAKWARFRHRLSTEGGHDDATIDRIKTPIGMTEITGKEPAAIAVGVAADLLRTFEQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRV7</accession>
    <name>A0A0F4JRV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946419.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37097">
        <property type="protein sequence ID" value="KJY37097"/>
        <property type="gene ID" value="VR44_06535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3220"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="179" mass="19362" checksum="E00AA2678ED78FB6" modified="2015-06-24" version="1">MTRRSEFSDRVLPDAVVVPRKGVRLYFASSKTDQGAEGEWVVMPRRDDVLDPVTAYTEYRDALAAAGITTGKILRRIDRWGNIGDELSAESVNDIIQALADAAGVLYDDNGVKLTAHGLRASGATIADENGASGAAIRKQGRWSPNSKVADGYIRPRDEWEGNAMASVPSIPAQRTDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS89</accession>
    <name>A0A0F4JS89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946589.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36699">
        <property type="protein sequence ID" value="KJY36699"/>
        <property type="gene ID" value="VR44_07460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3967"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="204" mass="21552" checksum="E541D212E9B0986E" modified="2015-06-24" version="1">MSGIPPFPPEKAALRRELIAARRSLSPESRRTAARALARSALALPELAGARTVAAYVSVGAEPGTRELLDALREAGKRVLLPLLLPDNDLDWAAYEGPGSLAEAAHPGKMRLLEPSGPPLGPQAVTGADAVLLPGLAVDRRGMRLGRGGGSYDRVLERLERAGAHPALVVLLYDEEVVARVPEEPHDHPVQAVATPSGVVRFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JT14</accession>
    <name>A0A0F4JT14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_06000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000110">
        <property type="protein sequence ID" value="KJY37325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946321.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000014_gene2627"/>
    <dbReference type="EnsemblBacteria" id="KJY37325">
        <property type="protein sequence ID" value="KJY37325"/>
        <property type="gene ID" value="VR44_06000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2414"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470854" evidence="7">
        <location>
            <begin position="42"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="203"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="9">
        <location>
            <begin position="963"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY37325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="1111" mass="115464" checksum="C66A2F095FDBE639" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTX1</accession>
    <name>A0A0F4JTX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XshC-Cox1-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000098">
        <property type="protein sequence ID" value="KJY37605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37605">
        <property type="protein sequence ID" value="KJY37605"/>
        <property type="gene ID" value="VR44_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="15961" checksum="3183CE8ED567A6E1" modified="2015-06-24" version="1" fragment="single">MFDIAGPLRSWCAERREFALATVVAVSGSAPRGPGASLAVDAGGTALGSLSGGCVESAVHELCLDAIASGRGGVHRFGYSDDDAFAVGLTCGGVLDVLVTPVRGQDPVRPVLGSVLDAAAGGGRAALARVVSGPPGQLGRALAVHADGSWEGGLSGGAALDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU39</accession>
    <name>A0A0F4JU39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_06065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000111">
        <property type="protein sequence ID" value="KJY37273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946329.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37273">
        <property type="protein sequence ID" value="KJY37273"/>
        <property type="gene ID" value="VR44_06065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2549"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="95"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="468" mass="51699" checksum="FC00995B5B0CD543" modified="2015-06-24" version="1">MSVQAGSESEAQTPQRSLGTAAARNLASTTKSAPQMQEITSRWLLKMLPWVSVQGGTYRLNRRLSYSVGNGIVEFVKTGSQVQVIPAELGELPLLRDYTDEDVLTELAARCRQLDFEAGQELTSFGSPSDQVFLLAHGRIDQIGPGPYGDDAVLRTVADGAFFGEDSLTEEEAIWEYTARAATSGTALVLTRQDFQILADRVPSLRAHVDSVRTRPERHANPYGEAAIDLSAGHHGEAVLPGTFVDYEARPREYELSIAQTVLRVHTRVADLYNHPMNQTEQQLRLTVEALRERQEHEMLNNPDFGLLHNADYDQRVQPHDGAPTPDDFDALLAMRRDSNLFLAHPKAIAAFGRECNKRGLYPETVDVAGTRVPAWRGVPIFPSNKIPISDARTTSILCMRTGEENQGVIGLHQPGIPDEIEPSMSVRFMGINEQAIISYLVTAYFSAAVLVPDALGVLENVEIGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUC2</accession>
    <name>A0A0F4JUC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_07620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36571">
        <property type="protein sequence ID" value="KJY36571"/>
        <property type="gene ID" value="VR44_07620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4136"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="97" mass="10611" checksum="B1495D59CD259593" modified="2015-06-24" version="1">MLEVSDSDALIGAALAHIKADEFMPDEERAHAESAVREDESEALAYLVDPTDLVAELAGVELAQASWSSEPVEYDPESLEWDLDEEDGVFEEEADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV43</accession>
    <name>A0A0F4JV43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_04410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000081">
        <property type="protein sequence ID" value="KJY38020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007267191.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000006_gene4252"/>
    <dbReference type="EnsemblBacteria" id="KJY38020">
        <property type="protein sequence ID" value="KJY38020"/>
        <property type="gene ID" value="VR44_04410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.451"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="220" mass="22784" checksum="D065BB1079CFDD52" modified="2015-06-24" version="1">MSVLLEQPASLVAYRPNKPTAMVVVADPRVRSTVTRHLWALGVRDVIEASSIAEARPRVGSPRDICVADVHLPDGSGLTLLSETRAAGWPNGLALSAADDIGAVRNALAGGVKGYVVTGTRTNIGLPTRPGAAPIGAAAARMHRRPPGAPSHPGGYRELSGREVEVLRLVAEGQSNKAIGVSMGLSALTVKSHLARIARKLGTGDRAGMVAVALRTGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWQ5</accession>
    <name>A0A0F4JWQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_03270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000059">
        <property type="protein sequence ID" value="KJY38565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945825.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38565">
        <property type="protein sequence ID" value="KJY38565"/>
        <property type="gene ID" value="VR44_03270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7869"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="441" mass="46572" checksum="B26AA9F8918065A1" modified="2015-06-24" version="1">MGLDTPQRLAVDALLDDPKTRIIVCCGAGGVGKTTTAAALGVRAAERGRKVVVLTIDPARRLAQSMGIDSLDNTPRRVEGVDGDGGELHAMMLDMKRTFDEIVEAHADRERARAILANPFYQSLSAGFAGTQEYMAMEKLGQLRAKDDWDLIVVDTPPSRSALDFLDAPKRLGSFLDGKFIRVLMAPAKVGGRAGMKFLNVGMSMMTGTLSKLMGASLLKDVQTFVAAMDTMFGGFRTRADATFRLLQAPGTAFLVVAAPEPDALREAAYFVERLAAESMPLAGLVLNRVHGSDARQLSAERALAAAENLEEGGIVDQEPGKAGLRDATDDGSPAVDDVDGDAESHPEDVDSAEHAGHARDAEGTDSAGAGDADAVTAGLLRLHAERMQVIAREQRTRDRFTSLHPEVAVAEVAALPGDVHDLAGLRAIGERLAAGVPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JWX0</accession>
    <name>A0A0F4JWX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000044">
        <property type="protein sequence ID" value="KJY38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38877">
        <property type="protein sequence ID" value="KJY38877"/>
        <property type="gene ID" value="VR44_02715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6849"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="119" mass="12958" checksum="3E003CE443FB5A13" modified="2015-06-24" version="1" fragment="single">AADLYLRVRLAPHPRYRVDGRDVTVDLPVTPWEAALGASVPVDTPGGTATVDLPPGSSSGRRLRLRGRGMPNPRGQPGDLYAEVKIVVPPRPTQAERDLFERLAKESRFDPRNPPSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX16</accession>
    <name>A0A0F4JX16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD</name>
        <name evidence="12" type="ORF">VR44_03730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945904.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000090_gene3541"/>
    <dbReference type="EnsemblBacteria" id="KJY38394">
        <property type="protein sequence ID" value="KJY38394"/>
        <property type="gene ID" value="VR44_03730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8649"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY38394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="197" mass="22211" checksum="8F63D0331FDDA581" modified="2015-06-24" version="1">MEAFTTHTGRAVPLRRSNVDTDQIIPAHWLKKITRDGFEDGLFEAWRKDPEFVTNRPERAGATVLVAGPDFGTGSSREHAVWALQNFGFKAVISSRFADIFRGNSLKNGLLTVVLPQETVDRLWELTEADPTAEITVDLVDRKVRAEGVEAEFELDDNARWRLLEGLDDISLTLQNEADIDAYESTRPAFKPRTIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JX21</accession>
    <name>A0A0F4JX21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">VR44_03760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945909.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene787"/>
    <dbReference type="EnsemblBacteria" id="KJY38399">
        <property type="protein sequence ID" value="KJY38399"/>
        <property type="gene ID" value="VR44_03760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8655"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="165"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY38399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="41787" checksum="E38ABDEC0BD8BE62" modified="2015-06-24" version="1">MSSENLPQTPEQQGRKPRVAVVFGGRSSEHAISVVTAGAVLRSIDRSKYEVLPIGITTDGRWALTADAPERMAIADRRLPDVESLAESPDGTVVLPVDPASREVVYTEPGSVPKALGEVDVVFPVLHGPYGEDGTLQGLLELSGIPYVGCGVLASAVGQDKDYMKRVFTSFGLNVGPYVTIRPREWEADQDAARTKVLDFAAEHGWPLFVKPARAGSSIGITKVDDASGLDDAIREARLHDPKVIVEALLRGREIECGVLEFEDGPRASVPAEIPPVSSHDFYDFEAKYIDSATGLVPAPLTPEQTAEVQRLAIEAFEAASCEGLVRADFFLTEDGTFVINEINTLPGFTPISMYPRMWQESGIEYPELVDRLIQAALRRSTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYV3</accession>
    <name>A0A0F4JYV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_02520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945682.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39004">
        <property type="protein sequence ID" value="KJY39004"/>
        <property type="gene ID" value="VR44_02520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6808"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY39004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="88" mass="9600" checksum="7F89BBAC0EC4BB78" modified="2015-06-24" version="1">MTRDEALETIKAVIEEVVPGADLSSVSPRENFRAPLEMDSLDFLNFVELLSGRTGLALPEQDYPSLTTLESCADYVAAHTQGTQQDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JYY1</accession>
    <name>A0A0F4JYY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="10" type="ORF">VR44_04050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000074">
        <property type="protein sequence ID" value="KJY38211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945959.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000074.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38211">
        <property type="protein sequence ID" value="KJY38211"/>
        <property type="gene ID" value="VR44_04050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8715"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="73"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY38211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="278" mass="29695" checksum="302609FACBF6827F" modified="2015-06-24" version="1">MANYTAADVKKLRELTGAGMLDCKNALVEADGDVTKANEILRVKGLKGVAKREGRSAENGAVTSLISEDATSGVLVELKCETDFVAKSPKFLAVADQLAAHVAATKPADIEALLASEIEAGKTVQAFVDEANANLGEKIVLDRFAQYEGAFVASYMHRTMPDLPPQIGVLVELDKADADLAKGIAQHIAAFAPKYLTAEDVPAEIVESERRVAEETTRAEGKPEAAIAKIVEGRVNGFFKDATLLGQPYALDNKKSVQKVLDEAGVTLKRFTRIKVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZF3</accession>
    <name>A0A0F4JZF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_03740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945906.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene791"/>
    <dbReference type="EnsemblBacteria" id="KJY38396">
        <property type="protein sequence ID" value="KJY38396"/>
        <property type="gene ID" value="VR44_03740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8651"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="227" mass="23228" checksum="90D90D63F51355E3" modified="2015-06-24" version="1">MNKAQLVEAIADKLGGRQQAADAVDAVLDAMVRAVVAGDRVSVTGFGSFEKVDRPARYARNPQTGERVRVKKTSVPRFRAGQGFKDLVSGTKKLPKGDEVAVKKAPKGSLSGGASATVKKAAAKKATTAKKAAAKTTATKTAAKKTTAKKATATVKKTAAKTTVAKKTTAAAKKAAPAKKATAAAKKTTATAKKTAPAAKKATATKAPAKKTATRKATAKKTTARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K064</accession>
    <name>A0A0F4K064_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_01880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39328">
        <property type="protein sequence ID" value="KJY39328"/>
        <property type="gene ID" value="VR44_01880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5780"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="275" mass="30372" checksum="B31527002AF98257" modified="2015-06-24" version="1">MKPTVTLNQGLDVPRLGLGMWQIPDGDAESLVGTALEAGYRGIDTATSYRNERGVGAAVAASGIPRDEIVVTTKLWNSDHGTDEALRAFDASLERLGMDRVDIYLIHWPLPLRDRYLETWRVLEKLHAEGRIRAIGVSNFTAGQLTRLMDRCDIVPAVNQVELHPAFQQAQLREFHAAHGIATQAWSPLGSGQGLLDLPVLGEIARAHGRSPAQVVIRWHLQLGNLVIPRSSAAARIRENFDVFDFSLDEHEMARIASLDTGQRRGPDPDTFDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1R3</accession>
    <name>A0A0F4K1R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000028">
        <property type="protein sequence ID" value="KJY39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945597.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39161">
        <property type="protein sequence ID" value="KJY39161"/>
        <property type="gene ID" value="VR44_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471041" evidence="1">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="87" mass="9332" checksum="1AE8BB4CE3B64FED" modified="2015-06-24" version="1">MTVRNVVLISCCNECRCSAGTRSAARATASRMASQSTSAARTDSDTGIRWVTRCAPRSREYSPTPVTSAGRPVSSDCAHSATMFRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K220</accession>
    <name>A0A0F4K220_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">VR44_00465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945302.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1061"/>
    <dbReference type="EnsemblBacteria" id="KJY39968">
        <property type="protein sequence ID" value="KJY39968"/>
        <property type="gene ID" value="VR44_00465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.92"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="288"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="460"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY39968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="615" mass="65680" checksum="0147EE5216453251" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K2B3</accession>
    <name>A0A0F4K2B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000024">
        <property type="protein sequence ID" value="KJY39321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945551.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39321">
        <property type="protein sequence ID" value="KJY39321"/>
        <property type="gene ID" value="VR44_01835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5771"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="249"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="350" mass="37167" checksum="399CB1D81B460D35" modified="2015-06-24" version="1">MDISGTPLARSWGVGIRAVGGYLPEKVVSNADLEEVLLTRDEWIRENIGVETRRMAAEDEWTSDLGAAALKDACARAGVSPSEVDLVICGTYTPDNMAPPTAMRVIEKAGAHGATGFDVNSGACPGGVFALDVGAKYLASGEYRRVAVVLADVNTRTMDWKDPGPAVIFGDGAACYLLERCRPDRGVGLTLLRSDPSRYEAVWVAREKRTLRDGRPLTSAFGDNFATLSGKAVHEFAVGEVPEVIEELLARAGQDVSDVDLFALHQANLYIVRGIMAALGVPEDRTVTNIQKYGNTSGASVPLVLREADDLGRLSPGDQVVLAAFGSGLSIGAALVRWCGPEDFEAVATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K373</accession>
    <name>A0A0F4K373_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000014">
        <property type="protein sequence ID" value="KJY39616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945396.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39616">
        <property type="protein sequence ID" value="KJY39616"/>
        <property type="gene ID" value="VR44_00970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2907"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="103" mass="10756" checksum="E4A81394E2E0698F" modified="2015-06-24" version="1">MAQAMDRPPISLLATDGKPHPLQDTLVAVTLILGAVAFVTAFFHNLHLLSSWTGLLGIATGLYGQFISATTRERFALIIGLGAAGIGFFLGMAHGGLFGGWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I3M7</accession>
    <name>A0A0F4I3M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001734">
        <property type="protein sequence ID" value="KJY16590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY16590">
        <property type="protein sequence ID" value="KJY16590"/>
        <property type="gene ID" value="VR44_40370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY16590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="22849" checksum="CF05993F70663C7B" modified="2015-06-24" version="1" fragment="single">APAAHGGPQGTATQAAGGPGGSATRPGHPAGAHTGAPGAAQGTTTAGALTAEDLDRNADTLAELLADTVGSAERQLFELRTAAADDSRILGALGDGGLLPPGPDVLATVEYLGEHGIPALPGWRYLAQSVAPADHAAVLAARPELVDGVIITDPDTHTRAREVLSGAALLPRSTVAVGTAAALLAPVPPADGSDAVFLVPPNPAMHDEHAADEERQALRARATARDTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I5H3</accession>
    <name>A0A0F4I5H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_40060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001681">
        <property type="protein sequence ID" value="KJY17240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY17240">
        <property type="protein sequence ID" value="KJY17240"/>
        <property type="gene ID" value="VR44_40060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6352"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY17240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="61" mass="6754" checksum="46597FEB56C4600E" modified="2015-06-24" version="1" fragment="single">MVTLRALTLDDAPALTRIYSGASVRYTTGRALPLDQAQEKIRSALTRAAETPRAQWSWGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IER7</accession>
    <name>A0A0F4IER7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_38825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001517">
        <property type="protein sequence ID" value="KJY20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952395.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20179">
        <property type="protein sequence ID" value="KJY20179"/>
        <property type="gene ID" value="VR44_38825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5478"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="211" mass="22180" checksum="40971656AA42D908" modified="2015-06-24" version="1">MAAEQQNPETTRAHGGLPDLTGPLPPPPLLDLVRARGAWVREELAHGTFEAWHFFPHGSAGSAPTHVFIQPVASGDPAAVARGVTTTVLRELRPAGAAEAARRGHRRGNAERYPLAERVEELLRTSDRPTEAYLAAVALRYERLADAGNRSPVRSLVDITGLPLGTVKSHIQLARKKGLLEAVGAKAGGRATRRAHAVVAAAEAGAGDGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IKX8</accession>
    <name>A0A0F4IKX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001424">
        <property type="protein sequence ID" value="KJY22339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952229.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001424.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22339">
        <property type="protein sequence ID" value="KJY22339"/>
        <property type="gene ID" value="VR44_37935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="244" mass="26329" checksum="277FB23BE4A6D61F" modified="2015-06-24" version="1">MWVVVPAHEEAARLGGTLRALAAQRDRDFTLLVVDNASKDATGAIAREFAARAPFPVEVIEEPEKGVGSAVDTGFRYAIARGATLLARTDADCLPGPGWAGAARAALAARPGLVCGRITARRDEHGPLGRAAFAGLVGLAALFGRLRPQHARRHGYRAPYRMHAGNNMAITAELYLAVGGMPRRPSPTDRLFLNAVRRHTDRISRCRGMVVENSTRRLRAYGLTGTARWYLDQGSGTHGTDDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IP04</accession>
    <name>A0A0F4IP04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001368">
        <property type="protein sequence ID" value="KJY23765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23765">
        <property type="protein sequence ID" value="KJY23765"/>
        <property type="gene ID" value="VR44_37345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4887"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469670" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15070" checksum="6C9DFA37FE6C85A7" modified="2015-06-24" version="1">MRLAVGAATLTAAVVATATSASAYVLTDIQTGAGKCPANWVCLWSESNFVRGNPAGGYDFGAVGSDQNVSDMGKFVFESKLFRWKGMQDSASSVVNNTSSGICFYEHNNYGGLEFRIGPREQWASVPGWINDKISSFKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IQF0</accession>
    <name>A0A0F4IQF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_35985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001267">
        <property type="protein sequence ID" value="KJY24222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951864.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001267.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2353"/>
    <dbReference type="EnsemblBacteria" id="KJY24222">
        <property type="protein sequence ID" value="KJY24222"/>
        <property type="gene ID" value="VR44_35985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4355"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY24222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="343" mass="38847" checksum="1D8C8DC760309992" modified="2015-06-24" version="1">MAMPLRQSIRVGTYLFEQKLRKREKFPLIVELEPLYACNLACEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIHEIVRQLVARRKYVFLCTNALLLRKKIEKFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVAAIKEAKRRGFRVTTNSTFFNTDTPQTVIEVLNYLNDDLQVDEMMISPAYAYEKAPDQEHFLGVEQTRELFRKAFAGGNRRRWRLNHSPLFLDFLEGKADFPCTAWAIPNYSLFGWQRPCYLMSDGYVPTYRELVEETDWSKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAARETVAGNRDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRP2</accession>
    <name>A0A0F4IRP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_36220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001283">
        <property type="protein sequence ID" value="KJY24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951908.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001283.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3766"/>
    <dbReference type="EnsemblBacteria" id="KJY24143">
        <property type="protein sequence ID" value="KJY24143"/>
        <property type="gene ID" value="VR44_36220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4488"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="319"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="499"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="558" mass="59770" checksum="9988BCB05969DC36" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS49</accession>
    <name>A0A0F4IS49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001223">
        <property type="protein sequence ID" value="KJY24469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951728.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001223.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24469">
        <property type="protein sequence ID" value="KJY24469"/>
        <property type="gene ID" value="VR44_35265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4163"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12059" checksum="4C101D368C483CAD" modified="2015-06-24" version="1">MIFHIVPLSDWSAAPELPYAPASLASEGFVHCSADRPTVLAIAGSHYREVPGPLLAVELDEAALTAEVRRTGGPGDPYPHVHGPLNRDAVVRVWEVVRTPGGGPAELTPWHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IS98</accession>
    <name>A0A0F4IS98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001213">
        <property type="protein sequence ID" value="KJY24519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24519">
        <property type="protein sequence ID" value="KJY24519"/>
        <property type="gene ID" value="VR44_35115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12429" checksum="97F0FF4C0839444D" modified="2015-06-24" version="1" fragment="single">LALARTHAAEALDLDATDWATLRTLAAVVLAALEARDTALCERLLSGSPPDAAHGHLPSLRLLIRGSAAALRQDLPTALDCYLDWGRTAERAHWRNPAVAPWRSWVSALHYRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISG8</accession>
    <name>A0A0F4ISG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_35450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001231">
        <property type="protein sequence ID" value="KJY24418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5703"/>
    <dbReference type="EnsemblBacteria" id="KJY24418">
        <property type="protein sequence ID" value="KJY24418"/>
        <property type="gene ID" value="VR44_35450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="215"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="451" mass="48389" checksum="213D77877E1FF0BB" modified="2015-06-24" version="1" fragment="single">MTLPVALSGTDVIGQAKTGTGKTLGFGLPLLERVVVPADVEAGRATPEQLTDAPQALVVVPTRELCTQVTNDLLTAGKVRNVRVLAIYGGRAYEPQVEALQKGVDVIVGTPGRLLDLAGQKKLDLSRVKALVLDEADEMLDLGFLPDVEKIMNLLPAKRQTMLFSATMPGAVIGLARRYMSQPTHIRAVSEDGEGATVANIKQHVFRAHNMDKPELVSRILQAEGRGLAMIFCRTKRTAADIAEQLERRGFASGAVHGDLGQGAREQALRAFRNGKVDVLVCTDVAARGIDVEGVTHVINYQTPEDEKTFLHRVGRTGRAGNKGTAVTLVDWDDIPRWQLINKALELDFHDPVETYSTSPHLYEELGIPAGTKGILPRAERTRAGLKAEELEDLGETGGRGGRGGRGAAAPAEERPARTRTPRQRRRTRGGSELGAEAEAAVASPAAEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISM9</accession>
    <name>A0A0F4ISM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_37490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001381">
        <property type="protein sequence ID" value="KJY23716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952141.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001381.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23716">
        <property type="protein sequence ID" value="KJY23716"/>
        <property type="gene ID" value="VR44_37490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4917"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY23716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="93" mass="9655" checksum="9718192036B254F9" modified="2015-06-24" version="1">MTGPRQYQWQDEVLAGPGGAMTDEVGVITGPLTLRTTGGPDGTVRFEVQYTDADEWYTLTGSPAAHGDPHALHTAALRAIRAGGGAEAPVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ISX8</accession>
    <name>A0A0F4ISX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_33395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001119">
        <property type="protein sequence ID" value="KJY25110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25110">
        <property type="protein sequence ID" value="KJY25110"/>
        <property type="gene ID" value="VR44_33395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3557"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="229" mass="23365" checksum="FCCCB88D996569A9" modified="2015-06-24" version="1">MAGAGTVRRPWGRRWTAFVRGAFVAAPVCLLVYGVVRLADPDHGPGPAWTFGHLALAAGVGLFGVVFLGLRRLAVPAGRAGRVGAGVATGLGLAGAAAAFAQAVIDLVVGLRSADRAGMDRLFEEIQSRPGVEPAVYSVGPLLFYVGLLWIVTQLAAGRRTGVWRPAAVLLGTAVMGVSLDLIPLGALLFCAALAPLGRDLAARECAARADLAYSGGDPYGAAGLRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IT84</accession>
    <name>A0A0F4IT84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_34105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001156">
        <property type="protein sequence ID" value="KJY24864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24864">
        <property type="protein sequence ID" value="KJY24864"/>
        <property type="gene ID" value="VR44_34105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3748"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470230" evidence="7">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="199" mass="20887" checksum="2838504538113F6E" modified="2015-06-24" version="1" fragment="single">VFVVLVGFLACAMASQGGAARGVYSLARDGVFPFSGQVRRVNRRQAPIGGLLASTAVSCSALFLGLNATAIGSLIAFGTAATFLPFFLVSLAALVARLRGTWVPSGHIRLGRKGTFLNVLAVLWTAFEVANVCWPRAILAPPGAPWYQIWAGLLGTGVVITAGLLYLLVRRPQEKLRALEPQAARTSPDRSGEPAAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITI0</accession>
    <name>A0A0F4ITI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001091">
        <property type="protein sequence ID" value="KJY25330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951273.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001091.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1399"/>
    <dbReference type="EnsemblBacteria" id="KJY25330">
        <property type="protein sequence ID" value="KJY25330"/>
        <property type="gene ID" value="VR44_32810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3375"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24895" checksum="FB7A00D93E937114" modified="2015-06-24" version="1">MPVPVLLAGRSVRLEPLAPHHTEALAEAGAEDRTTYAFTPVPHGLQASHEYIDRALADQAAGRSLAFAVVRASDGRVVGSTRFLELDYWQGPLVWPAVPGVPFGDPATAIPDAAEIGNTWLSPAAQGTGINTEAKLLMLRHAFETWGVRRISLRADARNGRSRAAMERLGFTCEGVRRAHSRGLDGAVRSTAFYSILDEEWPTVRSIIELRMSAAAPRRRRRRTLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITI4</accession>
    <name>A0A0F4ITI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001144">
        <property type="protein sequence ID" value="KJY24944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951476.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001144.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24944">
        <property type="protein sequence ID" value="KJY24944"/>
        <property type="gene ID" value="VR44_33885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3703"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469784" evidence="2">
        <location>
            <begin position="50"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY24944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="212" mass="22489" checksum="DE5AE880F08B4E2A" modified="2015-06-24" version="1">MSASSTPGHSRLTKAYKLSIAGVATLGAAALAFSVVPAGTGTQETQAVAAAPVAWTQSIQQNLGAQHAVADQKAKDAAKAQAEAQAKKDREAKEAASRSAARTPVFANNLDGWIKEALFIMKREGIPGTYEGIHRNIMRESSGNPRAINLWDINAKNGIPSKGLLQVIQPTFNAYHVKGTKFDLYDPVANIVAACNYAADRYGSMDNVNSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUG7</accession>
    <name>A0A0F4IUG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01001097">
        <property type="protein sequence ID" value="KJY25289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000049_gene3462"/>
    <dbReference type="EnsemblBacteria" id="KJY25289">
        <property type="protein sequence ID" value="KJY25289"/>
        <property type="gene ID" value="VR44_32885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3396"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="237" mass="24123" checksum="95E03406017E067A" modified="2015-06-24" version="1" fragment="single">MADAVPGLAEMAAAVAEGRVSSRELTERSLARIAAAQPSLNAFRIIRAEAALAEAEAADRRLARGERLPLLGVPVAVKDDMDVAGEPTAFGCAGDFPPKPADSEAVRRLRAAGAVVVGKTQTPELGQWPFTEGPAFGATRNPWDTQYTPGGSSGGSAAAVAAGLVPAALGSDGAGSVRIPAAWTHLVGVKPQRGRISTWPEPEAFHGLTVNGVLARTVADAALLLDAASGQAPGDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUJ5</accession>
    <name>A0A0F4IUJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_33285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001115">
        <property type="protein sequence ID" value="KJY25148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene35"/>
    <dbReference type="EnsemblBacteria" id="KJY25148">
        <property type="protein sequence ID" value="KJY25148"/>
        <property type="gene ID" value="VR44_33285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3533"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="105"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY25148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="304" mass="30980" checksum="EF39BB2CFC5EECE3" modified="2015-06-24" version="1" fragment="single">PSAPQGGAGGAEQAAVAAAEPFRTKMLSVPGLGEGAAGRRSRARTAHGRTTGAQRPRGQLTKLHLAATVHAAAPHQKARGRSGPGLVVRRDDLRQATREGREGNLVLFCVDASGSMAARQRMSAVKGAVLSLLLDAYQRRDKVGLITFRGAGAELALPPTSSVDAAAARLEKLPTGGRTPLGAGLLKAHEVLRVERLRDPSRRPLLVVVTDGRATSAGSVGGDPRELSGRSARLLAAEGVASVVVDCESGPVRLGLAGALAADLGAPAVTLDGLRADSLAGLVKNVRTAVTPTASANSVSRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUN5</accession>
    <name>A0A0F4IUN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_31775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001032">
        <property type="protein sequence ID" value="KJY25730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951091.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001032.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene96"/>
    <dbReference type="EnsemblBacteria" id="KJY25730">
        <property type="protein sequence ID" value="KJY25730"/>
        <property type="gene ID" value="VR44_31775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3066"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY25730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="256" mass="26049" checksum="D1F98B553307191C" modified="2015-06-24" version="1">MSVWESLAVLAAGIGAGTINTIVGSGTLITFPVLLATGLPPVTANVSNTLGLVPGSISGAIGYRKELRGQRGRVLRLGAVSLIGGLAGAILLLTLPSDSFDTIVPVLIGLALVLVVLQPKLAAALRRRQEAAGGDTAHPDGGPALLTGMLLSSAYGGYFGAAQGVLYLGLMGLLLHEDLQRINAVKNVVAALVNGIAAVFFLFVADFDWTAVLLIAVGSTIGGQIGAKVGRRLPPAVLRGVIVTVGILAIVQLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUQ7</accession>
    <name>A0A0F4IUQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001030">
        <property type="protein sequence ID" value="KJY25742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951079.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25742">
        <property type="protein sequence ID" value="KJY25742"/>
        <property type="gene ID" value="VR44_31730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3056"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="114" mass="12574" checksum="11784B0B1340A1F5" modified="2015-06-24" version="1">MVSHAQWKLSRDRKVAQGLAESAETARQREEIRLAFELGQAVYDRRSELGISQTELARRAGMTQPQVSKLELGGTVPTVPLLARLARAMESELTLKLVGETSHVVFAAQHHEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUZ8</accession>
    <name>A0A0F4IUZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_35225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001219">
        <property type="protein sequence ID" value="KJY24491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24491">
        <property type="protein sequence ID" value="KJY24491"/>
        <property type="gene ID" value="VR44_35225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="239"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY24491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="385" mass="40212" checksum="783C781773BD7E2B" modified="2015-06-24" version="1" fragment="single">MIRALTGCSTRHAWKVIAVWAVVGIALALLGQAFVYRATEPGDAGFLPESYDSAAALRIAEQDFGVRPDADPLTVLVARTDGAALTAADERRIGEVAGRLSRQRVVMPRAEDDTPLVQDHSQVPRIGAGATAPERAFRLIPVELTGNPQDPGVQGTYRAFREQARGAFQEAGLRTGFTGGLATTVDTADAEETRTMVVGLAMTGLIVLLHVLVFRSLAAALLPLLTVTIVGGAASGAVVGAALLTGIDLAPSTPGLINVVLIGIGIDYFLFLLFRFREQLRAHPGQSGREAAAEVAGRVGTAVTSAALTIVAAFATLGVASFGQFRVLGPAIAVAVLVMLLGSLTLMPALLAVTGRRMFWPSRSLRRAPRAGAAGRLGELAARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVF5</accession>
    <name>A0A0F4IVF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_32505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001073">
        <property type="protein sequence ID" value="KJY25443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951224.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25443">
        <property type="protein sequence ID" value="KJY25443"/>
        <property type="gene ID" value="VR44_32505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3305"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002469846" evidence="2">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="421" mass="44627" checksum="8251F9BB460D4002" modified="2015-06-24" version="1">MKKRFLAVCTALVAATALTAGCGVLAGSDGGSEKVTLWLMKGSASDEFIEKFTADFEKQHPGTDLEVKIQEWKGIGDKVNAVLAGKGKEHADVIEVGNTQVAQYVETGGLSELTLEGLRTWGSKDWLRGLSDPGSVNGAQYGVPWYAANRVVIYNKDLFAGAGIKTPPRNRQEWIAATQKLDKGDQQGIYLPGQNWYVLAGFVWDEGGELAVESGGQWVGALDDEKALAGMDFYKQLQALGKGPKNADEETPPQAEVFARGQVAQIIAPPGQAAQIEAANPALKGKLGYFPIPGKASDKAGSVLTGGSDLVIPARTAHRSGAVDLITALVSEKWQTELARTMSYVPNKTTLARVVEGNEGAAAMAAGAAQGRATPKSGRWAEVEAKNPLKPYMTAVLTGQDPRQAAKTASETMSQVLNSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVL3</accession>
    <name>A0A0F4IVL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000992">
        <property type="protein sequence ID" value="KJY26042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26042">
        <property type="protein sequence ID" value="KJY26042"/>
        <property type="gene ID" value="VR44_30970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2638"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="428" mass="44676" checksum="39738CB8B9AB203F" modified="2015-06-24" version="1">MPAAASGVQEQPSSTTAGSDAFYTYNGSKPLSSYSPGDVLKVRTLPYHVLGIATPLQATQLLYRTTDAQGHPSAGVTSVLRSPGGDGRKVVSYQSFYDSLDPEDGPSRAVAGNVRLPGGLIANGESTLVAPLLLSGYDVVLPDTEGQAAHLTASREYGYNTLDSLRAASSAESRTGISPDARVGLMGYSGGAVATNWAASLAPTYAPEVNKRLVGYAEGGVLVKPSHILRYIEGSQVWSGLIPELLIGQARSYDFDLKKYLNDYGKQLVDEHQHSSIADALGHYPGLTWKKMAKPEYANPNSVPELVEAVNKSNLGLAPTPTVPGYIGQGNAGFLEGTTSNIAGIGSGDGIAVAGDTRALARKYCAEGDAAVWYQQYDVLSHLTAPTATVPTALAWLRARFAGKEAPSSCGSIPEGNSLAADETVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW40</accession>
    <name>A0A0F4IW40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_31865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001037">
        <property type="protein sequence ID" value="KJY25673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951104.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25673">
        <property type="protein sequence ID" value="KJY25673"/>
        <property type="gene ID" value="VR44_31865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3087"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="348" mass="34883" checksum="3937400DE5B98238" modified="2015-06-24" version="1">MTQPTEHTDTGPAGGFLAEVKDAVTLRAAVLVLGVLALQLAFVTSYIGAFHHPKPSEIPIAVAAPAQPLAARTAERLGALPGEPLDPRAVADEATALAQIRNREVDGALIIDSQALEQIVGAAEKSQGRGVVVVDVAPADRGDSRGLSSFYLVVGWCVGGYLCAAVLAVSAGARPANVHRAVIRLGTLLLYSIAAGLLGTLIAGPVLGALPGPITALWGLGTLVVFAVGALTLALQGLAGVVGIGLAILLVVVLGNPSAGGAYPYPLLPPFWRAIGPALPPGAGTFAARSIAYFRGNGAAGPMLVLSAWAVAGSAVTLVCAAVRRGRPGAAVGSGLPDEATPTEWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXA9</accession>
    <name>A0A0F4IXA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000958">
        <property type="protein sequence ID" value="KJY26289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26289">
        <property type="protein sequence ID" value="KJY26289"/>
        <property type="gene ID" value="VR44_30415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2496"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="196" mass="20087" checksum="D38A60BEC866AAF4" modified="2015-06-24" version="1" fragment="single">MPRFVVEADGGSRGNPGPAGYGAVVLDPVTGETLAERAEFIGVATNNVAEYRGLIAGLKAARELAPDAEVRVRMDSKLVVEQMSGRWKIKHPDMKPLAAEAATVLPPAQVTYEWIPRERNKHADRLANEAMDAGRHGRQWEPPAPAPALTPAGPPGDAAKGAAAVRAAMASGGGTRTGASGASVGAAGARAATAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXL6</accession>
    <name>A0A0F4IXL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_30665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000972">
        <property type="protein sequence ID" value="KJY26198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26198">
        <property type="protein sequence ID" value="KJY26198"/>
        <property type="gene ID" value="VR44_30665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2588"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="146" mass="15693" checksum="B7AD89A0008843B4" modified="2015-06-24" version="1">MDDKNLELVHLLRAVTVEFGLRQAEFAAANGMHTTDVRALICLLDATRAAEPATAGLLGTRLGLNSAGTTAVIDRLERLGHVTRTRDPEDRRRVLLSVTPEAIRLGQDFFGPAIAELAGVSESLTPAERDAVRRFLTTARAAFSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXU9</accession>
    <name>A0A0F4IXU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-ribbon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_30410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000958">
        <property type="protein sequence ID" value="KJY26288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene4982"/>
    <dbReference type="EnsemblBacteria" id="KJY26288">
        <property type="protein sequence ID" value="KJY26288"/>
        <property type="gene ID" value="VR44_30410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2495"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY26288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="198" mass="21545" checksum="F1DBE3474B143ADB" modified="2015-06-24" version="1">MLVAAQTQASDAAREQTKAEQDVDQVRQRAARDQQRLESGVGISAKDLANLQSEVASLAKRQADLEDVVLEVMERLEGAQERVTEITGRVSALESKLADATARRDAATGELDAEAAKTAKDREVVVASMPADLMALYEKIRVKQGGVGAARLYQRRCEGCRLELDMAEINEIKAAARDQVVRHDNCGRILVRTADSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXZ0</accession>
    <name>A0A0F4IXZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_30255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000952">
        <property type="protein sequence ID" value="KJY26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950808.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000952.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26333">
        <property type="protein sequence ID" value="KJY26333"/>
        <property type="gene ID" value="VR44_30255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2461"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY26333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="569" mass="62737" checksum="02070D59462BADF8" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IY93</accession>
    <name>A0A0F4IY93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_28700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000881">
        <property type="protein sequence ID" value="KJY26967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5492"/>
    <dbReference type="EnsemblBacteria" id="KJY26967">
        <property type="protein sequence ID" value="KJY26967"/>
        <property type="gene ID" value="VR44_28700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2072"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY26967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34103" checksum="AC6DEB2F8B9CD2C4" modified="2015-06-24" version="1">MTMPTTLTAFADVTTSDSALRRFLHGLPGVDAVGLEARAASLGTRSIKTTAKAYAIDLAISMIDLTTLEGADTPGKVRSLAAKAVHPDPLDRTTPMTAAVCVYPDMVATAKAALNGADVKVASVATAFPAGRAALPVKLADTRDAVAAGADEIDMVIDRGAFLAGRYLETYELIKAVKEACVRPDGTAARLKVIFETGELSTYDNIRRASWIGMLAGADFIKTSTGKVGVNATPANTLLMLEAVRDFKAQTGIQIGVKPAGGIRTTKDAIKFLVLVNETAGEDWLTNEWFRFGASSLLNDLLMQRQKLSTGRYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0D7</accession>
    <name>A0A0F4J0D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">VR44_30155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000945">
        <property type="protein sequence ID" value="KJY26386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950790.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000945.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26386">
        <property type="protein sequence ID" value="KJY26386"/>
        <property type="gene ID" value="VR44_30155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2435"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY26386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="125" mass="13181" checksum="34D10826E839F9D2" modified="2015-06-24" version="1">MHEMSIAMAVVDQVAEAAQAGAARSVSRVELEIGELAGVVPDALAFAFELARAETPLEGAELVTHRVAARARCASCTGEWAVGMPPDLSCPGCGKATAVELLTGRELRIRRVVWDDALEPIPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0F7</accession>
    <name>A0A0F4J0F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000800">
        <property type="protein sequence ID" value="KJY27752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950187.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000800.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27752">
        <property type="protein sequence ID" value="KJY27752"/>
        <property type="gene ID" value="VR44_26840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1527"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="22146" checksum="A0B84E03CA4D15CF" modified="2015-06-24" version="1">MAGFRSLAYQVRDARNDRALRRHSLRRCLERFAPYGHRATWWHLCDRHGIAPEDRGADPLRLVAALEELEDARAVWLEYERQFAARRRREKHDGVRQPEWAWGGSGDAVVRCADPGVRPEGTLGEVLRRLVRALESEPGTACPVCGERELRWPSALSGPAAWGGGAWAWDGPVCGGCGIVVPRPALADTAMVHPAVAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J0W2</accession>
    <name>A0A0F4J0W2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribA</name>
        <name evidence="7" type="ORF">VR44_27715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="JZWV01000842">
        <property type="protein sequence ID" value="KJY27383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950344.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000842.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27383">
        <property type="protein sequence ID" value="KJY27383"/>
        <property type="gene ID" value="VR44_27715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1780"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY27383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23484" checksum="71B9F0B177DAA0E7" modified="2015-06-24" version="1">MATAFPVDENPGSDVPRCEIRAEVPVPIEAGGRTLTARMVTFSGLVDGREHLALVFGEELAPVPLVRLHSECLTGDVFGSGRCDCGPQLREATDRLADGGVLLYLRQEGRGIGLYNKLDAYVLQDQGLDTFEANRRLSFADDERDYRAAAQMLRALGVDGIRLLTNNPDKAAQLTASGIEVHDSVSTGVFLGAGNRRYIEAKVLHAGHRIALTEVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J178</accession>
    <name>A0A0F4J178_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_27405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000829">
        <property type="protein sequence ID" value="KJY27488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950288.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000829.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27488">
        <property type="protein sequence ID" value="KJY27488"/>
        <property type="gene ID" value="VR44_27405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1648"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="378" mass="40619" checksum="2613034FC1C5E878" modified="2015-06-24" version="1">MGQREAALRLDGQWARIRSGAAQAGPGEADQLLAELIAALREPARTDPECAARLGLRLGDLAGRRFAAGDRAGALAAIEEGLRHAQQAAGHAPEYARWYARGLINQGVWLAWPLSDAARLPRHPLGEAAEEGPGAMERAAGERARDLTRAAVEVWAGLDQHDPVNRRGLAQAKVFLGDRLAELGFAADAVAWAVDAEAGFRRLLLAAPGPEEAQEAEEALDHIGRQLELRLRYLSFDSLAVLRAGGLLPERLLPQAVVAARIQGASEEAVAARLGLDAEQVATMLEVTPWRAVWRVEVRGADGLWSVAPAPWRGSAEVRQRTAEDVGTEVVRGFMASPQYPGDSGLWRVRVWWHEEGDPAGARFRLVVGPDAPAPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1P3</accession>
    <name>A0A0F4J1P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_27140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000810">
        <property type="protein sequence ID" value="KJY27648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950244.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000810.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000027_gene6910"/>
    <dbReference type="EnsemblBacteria" id="KJY27648">
        <property type="protein sequence ID" value="KJY27648"/>
        <property type="gene ID" value="VR44_27140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="259"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY27648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="402" mass="43435" checksum="8E03F1F1587FF43B" modified="2015-06-24" version="1" fragment="single">MAEFTMELNEDQKQVRDWIHGFAADVIRPAAAEWDEREETPWPVIQEAAKVGIYSLDFYAQQFFDPTGLGIPMAMEELFWGDAGIALSIVGTGLAAIGVLANGTEEQIGTWIPQMYGTPDDVKVAAFCSSEPDAGSDVGAMRTRAVYDQAKDEWVLNGTKTWATNGGIANVHIVVAVVDPELGTKGHASFIVPPGTPGLSQGQKFKKHGIRASHTAEVVLEDVRIPGSCLLGGKEKLDERLARAREKAKAGGGERVKNAAMATFEASRPAVGAMAVGTARAAYEVALDYAKTRTQFGRPIIDNQGVAFQLADMRTQIDAARLLVWRASWMAIAGKPFTAAEGSMSKLYASEVAKKVTAQAVQILGGNGFTREYPVERMHRDAAIYTIFEGTSEIQRLVIART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2F4</accession>
    <name>A0A0F4J2F4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="8" type="ORF">VR44_25270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="JZWV01000727">
        <property type="protein sequence ID" value="KJY28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949891.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000727.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28477">
        <property type="protein sequence ID" value="KJY28477"/>
        <property type="gene ID" value="VR44_25270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1151"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="232" mass="24036" checksum="BFA749B868BE0C13" modified="2015-06-24" version="1">MSDRIIAACDGAAKGNPGPAGWAWVIADAEGRPERWEAGPLGRATNNVGELTALLRLLEAVEPGTALEVRMDSQYAMKAVTQWLPNWKRNGWKTAAGKPVANRELVEGIDALLAARDVEFRYVPAHQEGGDHLNAIADQAASDAAVSQEPAGTAHGATAPPVPAPARTAPARTAPARKAASGSGAARSGARTITAKFRGTCPCGQPYAAGEKIAKLGARWGHPDCRPAATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3G4</accession>
    <name>A0A0F4J3G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_24550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000701">
        <property type="protein sequence ID" value="KJY28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28805">
        <property type="protein sequence ID" value="KJY28805"/>
        <property type="gene ID" value="VR44_24550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.905"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="215" mass="23025" checksum="9A5256A13FF787C8" modified="2015-06-24" version="1">MRRFGVVTSTGTVDEVGARPLTAAPGTVRDLRGSLSRGPRRLNFPAGDIVVVSGLPGGGKSTLIKRAAPGGGIDSQDVRERWERRMPAALPYVVYRPLVRASHYWTLWRELRSGASLVVHDCGTQTWVRALLAASARRRGRRLHLLLLDATPEEALAGQAARGRGVSAYAFARHRAAVTSLLSAAESGHAPRGCASTTLLDRPAAANLTEITFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3U6</accession>
    <name>A0A0F4J3U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_24125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000693">
        <property type="protein sequence ID" value="KJY28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28930">
        <property type="protein sequence ID" value="KJY28930"/>
        <property type="gene ID" value="VR44_24125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.819"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="129" mass="14163" checksum="CACD4CA52A9CA8AA" modified="2015-06-24" version="1">MEHVRTYVSSGGTDGHLWHGVPTLLLTTLDRASGRAVRTPLVYGRDAGRLLVVAAGTGGPHHPSWYANLVAHPEVRVQVGTAAFPAWARTADPLERETYWEAMTGLWPLFDDQQATAWPRELPLVIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J482</accession>
    <name>A0A0F4J482_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_23600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000668">
        <property type="protein sequence ID" value="KJY29162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29162">
        <property type="protein sequence ID" value="KJY29162"/>
        <property type="gene ID" value="VR44_23600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.665"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="434"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY29162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="532" mass="54742" checksum="AC1615F45C90DC12" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4L2</accession>
    <name>A0A0F4J4L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_26550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000789">
        <property type="protein sequence ID" value="KJY27876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27876">
        <property type="protein sequence ID" value="KJY27876"/>
        <property type="gene ID" value="VR44_26550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1434"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="73" mass="7919" checksum="ECAC704DCB3A12C1" modified="2015-06-24" version="1" fragment="single">MNAYEPVELRQLTRPEDVRPGLREELADCWEAVVNSGGAVIAAEFPLPPVSRSHVAPVVDGLVRALDPALARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6T2</accession>
    <name>A0A0F4J6T2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_21350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000592">
        <property type="protein sequence ID" value="KJY30072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949162.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000592.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5724"/>
    <dbReference type="EnsemblBacteria" id="KJY30072">
        <property type="protein sequence ID" value="KJY30072"/>
        <property type="gene ID" value="VR44_21350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8995"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="171"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY30072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="313" mass="34377" checksum="B97AEACB5B5E0438" modified="2015-06-24" version="1">MEVPVSTHTERPLSLTAPSDIDRAAHHRLDEAWLAAAWSHPTTRVFVVSGGQVLIDDTPDGGTGIVMTPAFEAPATETHRYFLGTDEDGVRYFALQKDSLPGRMDQSARPAGLREAGLLLSPRDAGLMVHAVALENWQRMHRFCSRCGERTVVAAAGHIRRCPGCGAEHYPRTDPAVIMLVTDEQDRALLGRQVHWPEGRFSTLAGFVEPGESIEAAVVREVWEEAGVRVGEVEYVASQPWPFPYSLMLGFNARAVSSEITVDGEEIQEARWFSREELAEAFESGEVVPPSGISIAARLVELWYGRPLPKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Y6</accession>
    <name>A0A0F4J6Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_22490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000631">
        <property type="protein sequence ID" value="KJY29594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000011_gene1434"/>
    <dbReference type="EnsemblBacteria" id="KJY29594">
        <property type="protein sequence ID" value="KJY29594"/>
        <property type="gene ID" value="VR44_22490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7310" checksum="C700FE1EDCC3790F" modified="2015-06-24" version="1" fragment="single">AQERLARRAVARSARALLGNGAWWWSAGLNAAAALLHAAALRYGPLTLVQPLGALTLVAAVPLGARGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6Y8</accession>
    <name>A0A0F4J6Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_21505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000602">
        <property type="protein sequence ID" value="KJY29950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949194.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000602.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29950">
        <property type="protein sequence ID" value="KJY29950"/>
        <property type="gene ID" value="VR44_21505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.179"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046270">
        <property type="entry name" value="DUF6303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19820">
        <property type="entry name" value="DUF6303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="92" mass="10256" checksum="0532D35A8D75D69A" modified="2015-06-24" version="1">MTHVARLTNSFMGEWELYVVTDAPTRDWPFHEFGRTGPVPTLAERRAALTALGYESAEAGEWVWTESQNTFAERVELTASLTVRTVTAKAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J740</accession>
    <name>A0A0F4J740_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949098.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30202">
        <property type="protein sequence ID" value="KJY30202"/>
        <property type="gene ID" value="VR44_20990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8928"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="253" mass="27132" checksum="B8C82C5B24C8CD78" modified="2015-06-24" version="1">MSRSTGEVFGAPVCVSLATHDLDAAERFYGDVLGWRFLRSRLGEEFRVACAEGVPVAGIAAIVPRLGVPMAWTPYFAVVDADVTAARIRERGATTAIGPLAFAADRDGAVFGFWEGEVGPERWPDRDGPVSVELKARDAFAAAVFYGEVLDWAAELPGALDVAYEQDHVVVRRHNRTVARIDAGAVEAAPDPRARPRWEVHFAVPDLDEAADRAVRGGGAIACPVSTSATDRRVTLSDWAGTPFTVTEATETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J7X4</accession>
    <name>A0A0F4J7X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-O-methylguanine DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_23905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000682">
        <property type="protein sequence ID" value="KJY29036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949638.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000682.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29036">
        <property type="protein sequence ID" value="KJY29036"/>
        <property type="gene ID" value="VR44_23905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.756"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY29036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23916" checksum="90FCB5AD4EF583E1" modified="2015-06-24" version="1">MAESGEELAEAQREHWERTYGARPGMYGERPSEPAVRAAAVFRAAGAREVLELGAGHGRDALYFARAGFDVLAADFSPAGLEQLRRGAAAQGVGGRITTAVHDVREPLPLADASVDGVFAHMLLCMALSTPEIHGLVGEVRRVLRPGGAFVYTVRHTGDAHYRAGTSRGDGIWEHGGFAVHFFPRALVDALAEGWTLREVHPFEEGELPRRLWRVTQTAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8T1</accession>
    <name>A0A0F4J8T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000582">
        <property type="protein sequence ID" value="KJY30204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949100.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000582.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30204">
        <property type="protein sequence ID" value="KJY30204"/>
        <property type="gene ID" value="VR44_21000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8930"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="189" mass="20975" checksum="AA2A2A111AE4477F" modified="2015-06-24" version="1">MGHGGDVVAELTTDHDEVKEYFQKLGRTTGAEERRSLADLLTIELVRHSVAEEQYLYPAVREHLEEGDLIADKEIADHGRAERLMKQLQEEDAAGTRFTSVLRELEADVLAHIHDEEQNLFPALRRACSQEVLDELGDKTRRAKKTAPTRPHPGAPSTPPANKLLAPGMGLVDRARDLLSGRGKDDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9D7</accession>
    <name>A0A0F4J9D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000569">
        <property type="protein sequence ID" value="KJY30373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30373">
        <property type="protein sequence ID" value="KJY30373"/>
        <property type="gene ID" value="VR44_20630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8841"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="163" mass="17688" checksum="CC7ED80C1A10A87C" modified="2015-06-24" version="1">MVAGGLRVLFCGINPGLLSAATGHHFARPGNRFWPVLHLSGFTPRLLAPAEQRELLGYRLGITNVVARATARADELSAEEFREGGRILTAKVERLRPQWLAVVGITAYRTAFHDPKAVIGPQERTIGTTRIWALPNPSGLNAHWTAASMAEEFARLREAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAK7</accession>
    <name>A0A0F4JAK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000495">
        <property type="protein sequence ID" value="KJY31407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948569.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000495.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31407">
        <property type="protein sequence ID" value="KJY31407"/>
        <property type="gene ID" value="VR44_18150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8177"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="135" mass="14844" checksum="9B54E04B4D4944AD" modified="2015-06-24" version="1">MATQTAAARREDARAAYDAFVKECPTSQLLARISDKWVGLILSALGQAENGSMRYSELGRKIPGVSQKMLTQTLRSLERDGIVTRSVTASVPVRVDYRLTELGGSLGCLLSSVKRWAENHFDEVSAHRAAYDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAU0</accession>
    <name>A0A0F4JAU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_19365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000530">
        <property type="protein sequence ID" value="KJY30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948803.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000530.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30873">
        <property type="protein sequence ID" value="KJY30873"/>
        <property type="gene ID" value="VR44_19365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8481"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY30873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23238" checksum="CE0969ECE3C1EAFE" modified="2015-06-24" version="1">MLRVILAEDSVLLRAGLTELLGLGGHRVLAAVGDAPALLRAVEAERPDVVVTDVRMPPGLRDEGLRAALALRSRDPGLPVLVLSQYVATAYATQLFTGGSAAGLGYLLKDRVGEVEEFLDAVRRVHGGQTVIDPEVVRVLLAPRRADDPLARLTPREREVLALMAEGLNNQALAARLFVTEASVVKHAGSIFTKLELDPTEGNRRVLAVLAHLRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAY5</accession>
    <name>A0A0F4JAY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_21150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000588">
        <property type="protein sequence ID" value="KJY30136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949124.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000588.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30136">
        <property type="protein sequence ID" value="KJY30136"/>
        <property type="gene ID" value="VR44_21150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8953"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="62" mass="6528" checksum="7FFC85F490029D0D" modified="2015-06-24" version="1">MTYDRLVCANCAAPVSQGRCPVCRANRERLQQEGPFAGLNPMALIALMAVLVAALALVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBB5</accession>
    <name>A0A0F4JBB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000477">
        <property type="protein sequence ID" value="KJY31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31657">
        <property type="protein sequence ID" value="KJY31657"/>
        <property type="gene ID" value="VR44_17695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="383" mass="40550" checksum="48C748EAFC3CF23F" modified="2015-06-24" version="1" fragment="single">MNWALVAGLGTLLAASLAGALGVRRILQQRQRRAGQTIAQDNDPNSLEQLLTAAGEPAGVEILDRILRALAHQAATDERALPTLRGVLLAGKEVRLLLDESADPVAPFTAGPDSRTWTLDPVAVLPDAEMLNDVEAPYPGLVTLGAHEDGLLLADLTTCHVLLLDGTPEEVLEVGRALALELGTSGWTDYSEILTAGLGSRLAKLLPQGRIRTMPHLPAVAADLGELLLEAHQSGEQVLPWLMIGVGDHDQEHLAQLADALAAARNLKTAVVLPASEAAQRVFPHAEIIDVTTGQEALLAPLGLPVTLQRITDEQYRQYVHVLQISTQDPVPATGSWEFAESHDQAAACGRPLTLRSTTADAQDPGNPFPALIAASPATTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JC78</accession>
    <name>A0A0F4JC78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_20060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000554">
        <property type="protein sequence ID" value="KJY30576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948929.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000554.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1602"/>
    <dbReference type="EnsemblBacteria" id="KJY30576">
        <property type="protein sequence ID" value="KJY30576"/>
        <property type="gene ID" value="VR44_20060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8634"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="266" mass="28324" checksum="3FFC7F3D07AE4CF8" modified="2015-06-24" version="1">MGGTEHLTVDRQGATLVLTMNRPEAKNALSLPLLVGLYDGWLEADADDGIRSVVLTGAGGDFCAGMDLKALAGKGMAGDQYRDRLKADPDLHWKAMLRHHRPRKPVIAAVEGYCVAGGTEILQGTDIRVAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGRPYSAEEAARIGLVGRVVPEGTALEAALEIAERINACGPLAVEAVKASVYETAGMTEAEGLAAELVRGWPVFDTADAKEGARAFAERRPPVYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCM1</accession>
    <name>A0A0F4JCM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_17080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000453">
        <property type="protein sequence ID" value="KJY31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31940">
        <property type="protein sequence ID" value="KJY31940"/>
        <property type="gene ID" value="VR44_17080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7948"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="108" mass="10850" checksum="076BC86B89784C43" modified="2015-06-24" version="1" fragment="single">LLLYALRPGPAVVAAALVLAGLAHAHALGVDRMYVDAVPDELRGRAMTLLSTGVMTLQGVGMALAGAAAEVFPAHAVVAGSAVLGTLVVLVLLAELRATETPAGRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JCT0</accession>
    <name>A0A0F4JCT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_17720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000479">
        <property type="protein sequence ID" value="KJY31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31619">
        <property type="protein sequence ID" value="KJY31619"/>
        <property type="gene ID" value="VR44_17720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8041"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="71" mass="7809" checksum="955D49C78F99FE97" modified="2015-06-24" version="1">MTADSILNVRWRKASASDPFDNCVEVARLEDGEVGVRNSRFPSGPALVFTRDEMVAFIDGVKKGEFDGMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JD85</accession>
    <name>A0A0F4JD85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VR44_17655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000474">
        <property type="protein sequence ID" value="KJY31703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948474.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000474.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000038_gene4562"/>
    <dbReference type="EnsemblBacteria" id="KJY31703">
        <property type="protein sequence ID" value="KJY31703"/>
        <property type="gene ID" value="VR44_17655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8097"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="164"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJY31703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="295" mass="31219" checksum="86E01131C27B5DA5" modified="2015-06-24" version="1">MMPVAAILSGAAIGTGGALLIREILRPAPALGPALRRLNQPAPAPAAAGDQVVDRDERWGQWLLERLADVPGVRIPYKDLALTGSTPAKFLLTKVALAGGGLLLPPLSTVPFLLLGLPLYLPAIVAILAAAVLWFAPDLALRDKAKRARGEFAHAMAAYLDLVALRRAGNVSAEQAMEQAAQVGQGWAFQRIQAALAQSRVDKVPHWESLARLTAELDLPVMDDLAAIMRQSADDGASVYATLRSRAKNLRTELLAAQAADANANSEKMTAPGALLAVLVMLLIAFPAIIRMLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE40</accession>
    <name>A0A0F4JE40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">VR44_16750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="JZWV01000444">
        <property type="protein sequence ID" value="KJY32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948310.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000001_gene5399"/>
    <dbReference type="EnsemblBacteria" id="KJY32069">
        <property type="protein sequence ID" value="KJY32069"/>
        <property type="gene ID" value="VR44_16750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7786"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="236"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJY32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="530" mass="57436" checksum="A7397DFC100889E3" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JE94</accession>
    <name>A0A0F4JE94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000444">
        <property type="protein sequence ID" value="KJY32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948309.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000444.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32068">
        <property type="protein sequence ID" value="KJY32068"/>
        <property type="gene ID" value="VR44_16745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7785"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9873" checksum="FBC335B0133A4084" modified="2015-06-24" version="1">MNATLTTTAATPEQLIADCRERIDALDDRIIGLIQERMAVSAVIQEARIGAGGRRVHLSREMEVLSHFSDALGKPGTALAMTLLELCRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEQ4</accession>
    <name>A0A0F4JEQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_18125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000494">
        <property type="protein sequence ID" value="KJY31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948564.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000494.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31431">
        <property type="protein sequence ID" value="KJY31431"/>
        <property type="gene ID" value="VR44_18125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8172"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="214" mass="22285" checksum="B67710429ADFA61D" modified="2015-06-24" version="1">MLTLHTAELLVTGPGATPLEAGAVLVEGDRIVRTGPYEDLGAAAPHARVRRWPGVLTPGLLARGADVLLQGTYYPDDPYEVTELGADPITGAEALEALKLTESRWGNSARRGTQKLLARGVVAVAGRFTIPAVRTAVVRSGLAVVPPAPYEGAPALDPLTGRQSAGEAFHGVLEAGGAARFAVFAVADEAELLERGATTCVATVIGGRLLHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JES8</accession>
    <name>A0A0F4JES8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HSP18 transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000388">
        <property type="protein sequence ID" value="KJY32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948010.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000388.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32857">
        <property type="protein sequence ID" value="KJY32857"/>
        <property type="gene ID" value="VR44_15170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7454"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="221" mass="23332" checksum="65A2F5A6A5848D19" modified="2015-06-24" version="1">MPEADPPTTPVSFHAAAAALEAISRSVKDAQEAPPGASAPSPRPAGDRGPHPALTALLMLREVREQLAGWESVLIETARGQGASWAELAGPLGVASRQAAERRYLRLRPGAAGSTGEQRVQATRDSRAADRTVTAWARDNAADLRRLAGQVTSLTGLPASAEGAIGDLNLALADNDAARLVGPLTATRDHLPRDSGLTDRIDAMTRRTEQLRKDSNDQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JET6</accession>
    <name>A0A0F4JET6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_16180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000419">
        <property type="protein sequence ID" value="KJY32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32319">
        <property type="protein sequence ID" value="KJY32319"/>
        <property type="gene ID" value="VR44_16180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7665"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="107" mass="11511" checksum="3F7631BBC7151F85" modified="2015-06-24" version="1">MVTVPQVTVKTDVGGVRVVVCSGDFDLDTINVLVEACADEDSPAGPLVVDVAGVSFADSSFLNALVRLRNTRPLALRGPLPHQLRRVMELTGVLDLFDIRDRPGQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JEX6</accession>
    <name>A0A0F4JEX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_14995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000384">
        <property type="protein sequence ID" value="KJY32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947974.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000384.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32902">
        <property type="protein sequence ID" value="KJY32902"/>
        <property type="gene ID" value="VR44_14995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7416"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="76" mass="7782" checksum="DA3B401720348CF0" modified="2015-06-24" version="1">MFSPDGTLLASGSKDTTVRLWDVAKGESGAPLTGHDSDVVALAFSPGGRTLVTGGQDGAVRLWDVATHNVCGPPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFB5</accession>
    <name>A0A0F4JFB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000409">
        <property type="protein sequence ID" value="KJY32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32484">
        <property type="protein sequence ID" value="KJY32484"/>
        <property type="gene ID" value="VR44_15860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7581"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="153" mass="16432" checksum="7847228A1036E9B4" modified="2015-06-24" version="1">MQVLQVQLEVGPDPAEVGRARRWARSRLAGSGIGDDEPLAETLILLISELVTNAVVHTGCPAVLRMLLGGPGVRVEVTDASDRAPARRQAAGDDTGGRGLELVDGLADRWGWQREGAGKRIWCEIDRAVEEPPAAPSAPLGKVLLKREPRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFZ7</accession>
    <name>A0A0F4JFZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000396">
        <property type="protein sequence ID" value="KJY32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32724">
        <property type="protein sequence ID" value="KJY32724"/>
        <property type="gene ID" value="VR44_15285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7459"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="12525" checksum="DB2C6190B06669C7" modified="2015-06-24" version="1" fragment="single">ERAKGGAGRGSAQRHNDVRVLDGGEAWPPLGVLPVPPAAQPREIGQLRPGEALLLHTDGAEDARDRHGRFFPLAAFLTAQQTLTPARLVAGVHAALLRHTGGRLADDVALLALRNDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG01</accession>
    <name>A0A0F4JG01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4365 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000373">
        <property type="protein sequence ID" value="KJY33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947889.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000373.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3314"/>
    <dbReference type="EnsemblBacteria" id="KJY33125">
        <property type="protein sequence ID" value="KJY33125"/>
        <property type="gene ID" value="VR44_14465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7154"/>
    <dbReference type="eggNOG" id="ENOG503307N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025375">
        <property type="entry name" value="DUF4365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14280">
        <property type="entry name" value="DUF4365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4365" evidence="2">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="192" mass="20771" checksum="3737872AEC224137" modified="2015-06-24" version="1">MALAQPEPGGVLDADTGARTGPLRGTLATTACMETLQVGYLHAVAAAAGCSLSQPFPDNGIDWHVSHGAPEHAVDDEVTIKVQLKATYQVPPRPAGPTFGFTLDNEHLVKLARTPVAVHKILVVMLVPREREQWLSAGHDRLDLRHCCYWTNLAGHPVTGRRRTTVRIPTARIFDDRALCEIMTRVGSGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JHF1</accession>
    <name>A0A0F4JHF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_13295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000338">
        <property type="protein sequence ID" value="KJY33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947675.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000338.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene698"/>
    <dbReference type="EnsemblBacteria" id="KJY33777">
        <property type="protein sequence ID" value="KJY33777"/>
        <property type="gene ID" value="VR44_13295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6881"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="481" mass="50839" checksum="49854F01F114BAA7" modified="2015-06-24" version="1">MTSTHAFWLAGRQATGEDSFDVHNPWDGRLVGTVSVPTDAQVEEAVAAAHAVTAEFSATPAHVRAAALDHVSKRLVERTEEIAQLISAENGKPIKWARGEVGRAVSVFRFAAEEARRFNGGEAQRLDTDAGGVGRLALTRRFVKGPVLGIAPFNFPLNLCAHKVAPAIAVGAPIILKPAPATPLSGLILGELLAETDLPAGSWSVLPVANDKMPALVKDDRLPVISFTGSDTVGYAIQQSVPHKHCTLELGGNAAAVVLADWSSDADLDWAATRIATFSNYQAGQSCISVQRVIADASVYDRLVEKVVAKVQAQVTGDPADDATDVGPLVSEDAAKRVESWVDEAVSAGAKLLTGGKRDGASVEPTVLAEVPAGVKLATEEVFGPVLTITKVENTDEAFAAVNDSKFGLQTGVFTRDVQVAFRAHRELEVGGVIIGDAPSYRADQMPYGGVKQSGVGREGVRYAMDDYTYERVLVLTGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIK0</accession>
    <name>A0A0F4JIK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_12775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000319">
        <property type="protein sequence ID" value="KJY34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34010">
        <property type="protein sequence ID" value="KJY34010"/>
        <property type="gene ID" value="VR44_12775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6636"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470762" evidence="7">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="299"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="359" mass="37342" checksum="0DEE778E4EAA698E" modified="2015-06-24" version="1" fragment="single">MFRTALRNVLAHKARLLMTVLAVTLGVAFVSGTLVFTDTLGKALSGQSAKSYDGIAVSVTSWGPSRDEDGQKQGEPGISQQTLEKVKALGGVDSVSGRVSGFAGVGDENGRLIGSGWANKGSNYAPVKDGKDPRYTFTDGTGPAKDDQIALDKESAAKGGYKTGDKVRVATNGPVREFTLTGVFTTEDGAVNAGGSLVLFDTKVAQELYLQPGYYDELAVAAKAGTSADKLLADIKPLIDAKHAKAQTGKELAAKQAKDIEKQMSSFSTMLLAFAGISLFVGVFLIYNTFTMLVAQRTKELALLRAVGAKRGQVMRSVLAEALVIGATSAAIGLAAGIGLAVGMRSLMGSIGACLLYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJA4</accession>
    <name>A0A0F4JJA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_14660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947920.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33031">
        <property type="protein sequence ID" value="KJY33031"/>
        <property type="gene ID" value="VR44_14660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7259"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="258" mass="28265" checksum="0AAA0B17D6437FC3" modified="2015-06-24" version="1">MPPASRLAEAISSYTVQTEGNPFAELSAATSWEAVGKGRRGAVLTRTDGAGGVPLVRTTTRYGSPAQRFRAVHERLARQVQERAGLPAGFNNALVESYTNAYRTMGSHSDQALDLADGSSIAVFSCYRRGGEGPSRKLVFEAKASPGGGEGFEIPLAHNSVVVFSVESNRRLRHKIVLDGPAPAEDDEWLGVTFRTSKTLLRFRDGQAHLPGGERLVPADEDQSREFYRLRRRENQETDFVYPPLTYTISESDLLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JJY6</accession>
    <name>A0A0F4JJY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_11770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000283">
        <property type="protein sequence ID" value="KJY34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947391.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000283.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3726"/>
    <dbReference type="EnsemblBacteria" id="KJY34495">
        <property type="protein sequence ID" value="KJY34495"/>
        <property type="gene ID" value="VR44_11770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6321"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="351" mass="39260" checksum="7538915B9091417D" modified="2015-06-24" version="1" fragment="single">KDPIKFPDFIHSQKRDPFTGKQEPDNVWDFWAHAPEATHQITWLMGDRGIPASYRHMNGYGSHTYQWTNAQGEAFFVKYHFKTNQGIRCLSGEQAAELVGKDANSHQTDLLQAIERGVNPSWTLYVQIMPAAEAADYRFNPFDLTKVWPHADYPLQRVGRLVLDRNPDNVFAEVEQSAFSPNNFVPGITASPDKMLQGRLFAYADAQRYRLGVNHTQLPVNAPKATKADNYGRDGVMALRNGSRHDKNYEPNSYQGPAETGIALGAPKAVSGYTGTHEAPAHTKDDDFFQAGELYRLMSEAEKQRLVANIAGGLSQVTLEDVIEKNLAHFHAADADYGKRVEEAVRALRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKY0</accession>
    <name>A0A0F4JKY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947244.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000249.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34987">
        <property type="protein sequence ID" value="KJY34987"/>
        <property type="gene ID" value="VR44_11000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6084"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="131" mass="15172" checksum="B40341E3EE9B33AD" modified="2015-06-24" version="1">MRVRRLGELEAEIMDRLWQWERPASVREIVDDINRGRKVAYTTVMTVADILYRKGWLTREKSGRAWMYQAVRSREEYTAALMQDALGDSQDRRATLLRFVERMSHEDVEALDEALRAARSERPSGAGGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKY7</accession>
    <name>A0A0F4JKY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="11" type="ORF">VR44_10970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000249">
        <property type="protein sequence ID" value="KJY34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34997">
        <property type="protein sequence ID" value="KJY34997"/>
        <property type="gene ID" value="VR44_10970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6078"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="10">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="9">
        <location>
            <begin position="204"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJY34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="46901" checksum="8667DD94BFAAEB02" modified="2015-06-24" version="1">MLSVHTSPLHQPGTGDAGGMNVYMVQLSRALAEQGVEVDLFTRCRGEEHPDPAGLGPGVRVRHLEAGPRAPLPKEDMPALVVPFSLALLKEERRYDLVHSHYWLSGQAGRIAAAGWRIPFVHTAHTLARVKNAALAEGDAPEPELRIRGEHQVVGSADRLIANTGDEARALCELYGADARRTRIVRPGVDLATFGPGRGRAAARARLGLPADAFIPLYAGRIQPLKGPDVMVRAVAALLERAPHLRGRTLVPVVGGNSGAGPRGEAWELARELGVSEVLRHHPPVPQRELALWYRAADVLMVPSRSESFGLVALEAQACGTPVLASAVGGLPTAVRDGVTGVLVPGNDPAEYARRLLWFAEHPGEAEVMGRAAVSHARNMSWRGAAARTLEVYRDVLREEGARPGPDMSEAGAAARSCLADTSPLEGREGRNSTLAALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JL01</accession>
    <name>A0A0F4JL01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000247">
        <property type="protein sequence ID" value="KJY35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35012">
        <property type="protein sequence ID" value="KJY35012"/>
        <property type="gene ID" value="VR44_10955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6671" checksum="9A3CC3C169100A47" modified="2015-06-24" version="1" fragment="single">MCRIFGSLSAAPARPDPAELAAVSSRQRHGGPDEHRVLSGPGWSLGCDRLAVTDPRGGSQPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLP8</accession>
    <name>A0A0F4JLP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_13000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947621.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000015_gene2315"/>
    <dbReference type="EnsemblBacteria" id="KJY33886">
        <property type="protein sequence ID" value="KJY33886"/>
        <property type="gene ID" value="VR44_13000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6718"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="322"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="503"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY33886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="723" mass="77370" checksum="796D8C3DE41E165C" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLQ2</accession>
    <name>A0A0F4JLQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000268">
        <property type="protein sequence ID" value="KJY34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947340.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000268.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34693">
        <property type="protein sequence ID" value="KJY34693"/>
        <property type="gene ID" value="VR44_11490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6199"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="91" mass="9553" checksum="612B7E42C993EF51" modified="2015-06-24" version="1">MPSSANAAVGEFLYSTGPLPGIPAGIADPESRVCHNLYGATETDPAYAPKNLTNATATAFLDFDCAGDTYYVIAPGRVLGNRLKLRSVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLU8</accession>
    <name>A0A0F4JLU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000239">
        <property type="protein sequence ID" value="KJY35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947180.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000239.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35170">
        <property type="protein sequence ID" value="KJY35170"/>
        <property type="gene ID" value="VR44_10640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5873"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="465" mass="51856" checksum="44EE6CFEA54B1142" modified="2015-06-24" version="1">MNDPLNTLSRAGFEALMNRPLLTSIWHRRTHRVSRGSSVEAGSMSWASSEPRTPLTELEEAVLIAMTGCSGLTMPDRPFADPRDGKPIMAKPNLNMPGRTAGSPDNAQGTHFFLINDTGTYFLRKLPPPADGSTPEFDPETLCARAAEAKVRLLDHRLDVPEGKRDFPAYLDSNRFLSNLPGTTVLLPVVDLTRQYINGLMYLLTQPEGARPLIVDDRNLYRPAGVRKWVKSGFLNEDIKLPLGAIWAMRTQIEADLLLQNLMLTADAMGLGAWIHASLAPPIALGDPKFRADYGPMLGFDWTVPRWRPADVLRWHVPLPRYSNLRAAPVALRHDGEYLIKAMCPPNYPSMADAVDAVVAGKFGPKGIYSDEGLFARIYRGDFGSQYLHQASDYSADVIACTRDICTYIHETHGRFPAHCDTIHVPGVWLQTHHVENGYYERFFRDGLTGAHRTHDQNWHGADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM13</accession>
    <name>A0A0F4JM13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000261">
        <property type="protein sequence ID" value="KJY34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947292.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000261.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34808">
        <property type="protein sequence ID" value="KJY34808"/>
        <property type="gene ID" value="VR44_11240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6259"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="169" mass="18047" checksum="5AD5F7E4EF77B9D8" modified="2015-06-24" version="1">MCRSKRRNALWITAAALVVVASVGLYLFQPWKLFTTDRVDEAPPAAAGRQAGTVKQVASGAFISHEHETSGSVEIQQLPDGKATLRLTNLRTSDGPALHVWLSDQPVKKGGGDNLDDGKHIDLGGLKGNEGNQNYAIPAGTDLNKFTTVTIWCERFSASFGAAALSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNC1</accession>
    <name>A0A0F4JNC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_10400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000230">
        <property type="protein sequence ID" value="KJY35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947136.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000230.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35334">
        <property type="protein sequence ID" value="KJY35334"/>
        <property type="gene ID" value="VR44_10400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8397" checksum="57909914ABFD73CD" modified="2015-06-24" version="1">MSTPRVFVPAFHHHLRPAGRPRNADGRRAAGRPAWQSPYSPPPRRSRRARWARVPVMATTRTPLRRGHVAGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JP91</accession>
    <name>A0A0F4JP91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shy6-polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_11370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000264">
        <property type="protein sequence ID" value="KJY34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947316.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000264.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34751">
        <property type="protein sequence ID" value="KJY34751"/>
        <property type="gene ID" value="VR44_11370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6169"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16353" checksum="ADD752330BFC1A33" modified="2015-06-24" version="1">MKNTPSGIDRAAPVVARRELPIRAPAPAVWALLTYVPGWPTWQPDIAEARALTPLRPGAVFHWRTGGVDITSTVYAVDAPRLVLWGGRSQGITAVHRWTFTPSSGATLVVTEESWDGEPVRADAAAVAQALDRSLAQWLLHLKSASERAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPL5</accession>
    <name>A0A0F4JPL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ORF">VR44_09185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946908.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000199.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5108"/>
    <dbReference type="EnsemblBacteria" id="KJY35784">
        <property type="protein sequence ID" value="KJY35784"/>
        <property type="gene ID" value="VR44_09185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5101"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY35784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="395" mass="43003" checksum="59D6A30519DB9703" modified="2015-06-24" version="1">MRVVTTAQPLDVQPTPLALLLLGRESDPKSERGVECPGDLPSPSDPDLVARARAAKEKLGDKVFILGHHYQRDEVIEFADVTGDSFKLARDAANKPEAEYIVFCGVHFMAESADILTSDDQKVVLPDLAAGCSMADMATAEQVAECWDVLTEAGIAGSTVPVSYMNSSADIKAFTGKHGGTICTSSNAKKALEWAFEQGEKVLFLPDQHLGRNTAVRDMGMSLDDCVVYNPHKPNGGLTAEELRGAKMILWRGHCSVHGRFSLDSVNDVRERIPGVNVLVHPECKHEVVAAADYVGSTEYIIKALEAAPAGSKWAIGTELNLVKRLANRFAAEDKEVVFLDKTVCFCSTMNRIDLPHLVWTLESLAEGNLVNQIQVDKETESFAKLALERMLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQP2</accession>
    <name>A0A0F4JQP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_10470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000233">
        <property type="protein sequence ID" value="KJY35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947149.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000233.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35256">
        <property type="protein sequence ID" value="KJY35256"/>
        <property type="gene ID" value="VR44_10470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5837"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="647" mass="70268" checksum="9EE98A95D650FBBB" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR87</accession>
    <name>A0A0F4JR87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_06945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000130">
        <property type="protein sequence ID" value="KJY36882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946495.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000130.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5284"/>
    <dbReference type="EnsemblBacteria" id="KJY36882">
        <property type="protein sequence ID" value="KJY36882"/>
        <property type="gene ID" value="VR44_06945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3604"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07410">
        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117123" evidence="7">
        <location>
            <begin position="32"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="48"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="9">
        <location>
            <begin position="376"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY36882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="603" mass="64799" checksum="E86FC5731D5E52C2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRM5</accession>
    <name>A0A0F4JRM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000125">
        <property type="protein sequence ID" value="KJY37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37007">
        <property type="protein sequence ID" value="KJY37007"/>
        <property type="gene ID" value="VR44_06720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="314" mass="34001" checksum="39DE6316B01FBE26" modified="2015-06-24" version="1" fragment="single">MATTLLTFAVTDVLGHPPQAGTVAEVKLEWTDPRGTVTQCITVPLDRPVTRAVPAEEWSRIDLDVAHPDYVPESVTLTRSSPGAPVYWDNRGVAVTRDGDELRLTMELGRIRQSPLTPPPYPGTKARGDQPGVFFREGAGQPRRYAVLNQPAPPATPLWLEKVTVRTLTDAAPARGGQDGWDRLSTTDQVVALADTGGFLWLEYGGNDGALPPQPRFLVAVWAPKAPPSPVRAGGMDVVCYFTPSTAARGYPVSAYPFRTNYPYSVKRDTAADQPYVVVGYRHLLRDLNLVQAQHVSGRPAVVVVPVLPALPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRQ3</accession>
    <name>A0A0F4JRQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000210">
        <property type="protein sequence ID" value="KJY35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946991.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000043_gene6084"/>
    <dbReference type="EnsemblBacteria" id="KJY35626">
        <property type="protein sequence ID" value="KJY35626"/>
        <property type="gene ID" value="VR44_09610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="233" mass="24891" checksum="D5A5FE7B17A8D632" modified="2015-06-24" version="1" fragment="single">MRASLIQIAVTDGESVASRRSRAAELVREQGDSDLVVLPELWTVGAFAYEQFETEAEPLDGPTYEAMSKAARDAGVWLHAGSVVERAGDGSLYNTALVLSPAGELAATYRKIHRFGFDQGEAVLMSAGDSLTTVSLPEQTLGLATCYDLRFPELFRGLVDAGATTMVVSAGWPARRREHWTLLNRARAVEDQAYVLACATAGTHAGVEQSGHSLVVDPWGEVLAEAGPGETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRV0</accession>
    <name>A0A0F4JRV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_09485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000207">
        <property type="protein sequence ID" value="KJY35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946966.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000207.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35676">
        <property type="protein sequence ID" value="KJY35676"/>
        <property type="gene ID" value="VR44_09485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5298"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="422" mass="44425" checksum="CB992D0863D509FC" modified="2015-06-24" version="1">MGRRVVITGIGVLAPGGIGVSEFWDLLSSGRTATREITHFDASPFRSRVAAEADFLPELHGLTDQEIRRMDRAAQFGVVAAREAVADSGIELAGLDPYRTGVSMGTGVGAVSSLDKAYRAATDHGRLAAVDHMRAPADLYDHFVPGSFATEVAWAVGAEGPATVVSTGCTSGIDSVAHAVDLIREGSADVMVTGATDAPITPLTLACFDAIKATTSLNDDPARASRPFDATRRGFVLGEGAAVFVLEELESARRRGATPYAEIAGYASRSSAFHMTGLRPDGRELAEAITVALDEAHLNPSDLDYVNAHGSGTRQNDAHETAAYKLALGPYAHRTPVSSVKSMIGHSLGSVGSIEIAASVLAMRHHLVPPTANLRTRDPQCDLDYVPLVAREHRTDAVLTVGSGFGGFQSAMVLARPDRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRV3</accession>
    <name>A0A0F4JRV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946414.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37092">
        <property type="protein sequence ID" value="KJY37092"/>
        <property type="gene ID" value="VR44_06505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3214"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="100" mass="11368" checksum="7E826E51255DD31E" modified="2015-06-24" version="1">MNDFWSRKVSELTEQQHRAEEEAMAAQLTYRNPNLPAGSQECIDIRRAQVERNHAMDVVLGIGQGAADRLRREAHLRVLQRYGVTVDDLKGRPAAAWDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSE2</accession>
    <name>A0A0F4JSE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000119">
        <property type="protein sequence ID" value="KJY37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946407.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37085">
        <property type="protein sequence ID" value="KJY37085"/>
        <property type="gene ID" value="VR44_06470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3207"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="86"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="389" mass="42944" checksum="EF6CB4B46DD32EA4" modified="2015-06-24" version="1">MTTFTEVVECLGGDFPAGAFGRQHRVWNNVADFSGLLSWDDVNEIVARGRLEPPRLRLHRDGEQIPWQTYATPVTTRRSTVWQRIQPSRLHQQLKDGASLVLDAVDELHAPVEALARDLESVFRSHIQVNMYASWTGREGFGTHWDDHDVVVVQLEGAKRWRIYGPTRINPLYRDLEAPQPPEGEPLAEIMLRAGDMLYLPRGWWHAVAATEGRSLHLTCGLQTTTGADLIGWLSERLRGSETVRAHLPAFGTVADHAAYLETLRKEISEALHDGVITEYLDHRDATEPGRPTPFLPYLDAVPAEPDLRVRLTTARARTTTNAEGQVVLMAGGQQWTFAPAAVPVLAPLVAGESPTLGFLAEDAGLTVEQVASLVAELVSADVATVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSU8</accession>
    <name>A0A0F4JSU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VMAP-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000112">
        <property type="protein sequence ID" value="KJY37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946349.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000112.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37255">
        <property type="protein sequence ID" value="KJY37255"/>
        <property type="gene ID" value="VR44_06175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2570"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045450">
        <property type="entry name" value="VMAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20028">
        <property type="entry name" value="VMAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VMAP-C" evidence="2">
        <location>
            <begin position="261"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="505" mass="54128" checksum="3CFC9219BECBEADA" modified="2015-06-24" version="1" fragment="single">DEIEAGMSGGPVVDLTRGEVIGVVKARRHTGGGGLAVSVAQLRTLPMAATGQTGLYRRVMQAHDLYHYDRHLSDLDSRRTWTDVHDLLADGEADAYGGRGRLTPGERTTLCGLLAELPPPGSSEAVRELAEQARGEEPDGTLPAPLSWRDGLGLLHDPPGAGGEAAAVLRYATGVSVADHREPPAPGTDEELWDWVRTTAERLWRPLRRELAERHERGLAERERRRRQAAGHAALGHALRAQGLPAGPSVLLEAWAHGWEDVYDWRVSVLAGPARPGRVTPVAAGVRATLAGLPEALRAPLAEGFRRCDTHEAAALLEVAVAPELFGLAVDEWAVSGGVPVGVQRPVVFRHPEGTGSAAAGARWARVQAGPLLDQRADCSRGRPRSPSPDWLQGLPDTTVPVLCRDPAAEPTLGALHSVRDAGYGVTVCRRPPADPTASCAPFHRGLREEFTEAARGAVLPQRLQALRRRAHGADPDAYWAAGLALVWEDPDRSLPEDEPLQGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSZ2</accession>
    <name>A0A0F4JSZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000180">
        <property type="protein sequence ID" value="KJY36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946812.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000180.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36076">
        <property type="protein sequence ID" value="KJY36076"/>
        <property type="gene ID" value="VR44_08650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4943"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="156" mass="17229" checksum="B3461465A0120AEB" modified="2015-06-24" version="1">MSTLHSILEQMTPEAREALLAHSHRVTFPAGTRIFKERRRAEKFWIIECGTVDLDTHVPGHKDAIIDTLGYGELLGWSWMFRPYTWHLGATATHDVIALEFDAAAVRELCTEDSAVGRSVSTAVAAVIADRLDAARTRLLDLFAPHGSGTPLAHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU11</accession>
    <name>A0A0F4JU11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000160">
        <property type="protein sequence ID" value="KJY36441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36441">
        <property type="protein sequence ID" value="KJY36441"/>
        <property type="gene ID" value="VR44_07980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4420"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="14737" checksum="27240357F3E7B531" modified="2015-06-24" version="1">MSVQVETMPYRHVLDVPAMGSAVRIARETTELVLVECGVGLRHPSVGPALLIVAELVTNAVRHAAVSSPMITVTYAHGPGAFAFAVHDRHPYQPALFGALGTAPGSGLAMVVEMTMELGGTAVVRADADGRGKAIWITLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUP8</accession>
    <name>A0A0F4JUP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000078">
        <property type="protein sequence ID" value="KJY38082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38082">
        <property type="protein sequence ID" value="KJY38082"/>
        <property type="gene ID" value="VR44_04285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.423"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471370" evidence="2">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="14667" checksum="8253956D2E16E38D" modified="2015-06-24" version="1">MKTCHKGALVAIAAVLSLAACDPATPAGSPSATAGVSSSPSAISSPSPSSTPSPATTPTTATPTPPAPSAAPPTTAAPAPAPERPHTEEPAPEPTRASTDCYPRSNAGNCYKAGQICRKADVGTSGRDAGGRAIYCRHDSGVGQRWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JUS6</accession>
    <name>A0A0F4JUS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_04255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000077">
        <property type="protein sequence ID" value="KJY38117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945999.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene845"/>
    <dbReference type="EnsemblBacteria" id="KJY38117">
        <property type="protein sequence ID" value="KJY38117"/>
        <property type="gene ID" value="VR44_04255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.142"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY38117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="390" mass="42037" checksum="982198FE6750837D" modified="2015-06-24" version="1">MSQDSTAVIADAGRKLAGRRRREIVAVLLFSGGPIFESSIPLSVFGIDRQDAGVPRYRLLVCAGEDGPLRTTGGLELTAPYGLEAIARAGTVVVPAWRSITSPPPPEALDALRLAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVDPRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGSEAAGALARRLVVPPRRTGGQERYLDRSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRSAYRARRPQGSDAPVSEISGTALPHQRTPQPQRAAAALAASGPSVTELYAPGRVLREHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVK8</accession>
    <name>A0A0F4JVK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_04745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000088">
        <property type="protein sequence ID" value="KJY37884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37884">
        <property type="protein sequence ID" value="KJY37884"/>
        <property type="gene ID" value="VR44_04745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1029"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
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    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2858"/>
            <end position="2933"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1374"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJY37884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="2945" mass="312942" checksum="8FDA775F627D988A" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXB2</accession>
    <name>A0A0F4JXB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">VR44_03755</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="JZWV01000068">
        <property type="protein sequence ID" value="KJY38398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945908.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000018_gene788"/>
    <dbReference type="EnsemblBacteria" id="KJY38398">
        <property type="protein sequence ID" value="KJY38398"/>
        <property type="gene ID" value="VR44_03755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8654"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="183"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJY38398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="336" mass="35058" checksum="EA17283143D7DDAB" modified="2015-06-24" version="1">MTRPVKAAVFSAGSWGTAFGMVLADAGCEVTLWARRPEVADAINTGRTNPDYFPGVELPANLRATTDPAEAARGADFTVLSVPSQTLRGNLAAWAPLLEPDTVLVSLMKGIELGTAKRMSEVIEEVAKVPAERVAVVTGPNLAREIVARQPAASVVACVDEAVAQRLQAACHTAYFRPYTSTDVIGCELGGAVKNVIGLAVGIADGMGLGDNTKGSLITRGLAEATRLGLAMGADPLTFSGLAGLGDLVATCSSPLSRNHTFGTNLGRGMTLEETIAVTKQTAEGVKSCQSVADLARRYGVDMPITDTVVDIVHHGKPTLVALKELMGRSAKPERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXB7</accession>
    <name>A0A0F4JXB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000038">
        <property type="protein sequence ID" value="KJY39002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945680.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39002">
        <property type="protein sequence ID" value="KJY39002"/>
        <property type="gene ID" value="VR44_02510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6806"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="219" mass="23999" checksum="8791FB9D967B1F2B" modified="2015-06-24" version="1">MRHREVGELMTREVVTVPGHATFKDIVRTLGRHKVSAVAVTDAAGHPLGVISEGDLLPKSADQGEWFHSLPRPEPWESGKAAGTTAEELMSAPPVCARPDWTVAEAARLMESQRVKRLLVVDDADVLVGIVTRGDLLRIFLRDDDAVRQEITGDVLDRTLHLDPSAVSVSVEDGEVTLHGVLRFRSLIPVVERLCRAVDGVVGVTERLAWETDDVGEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JXJ1</accession>
    <name>A0A0F4JXJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000060">
        <property type="protein sequence ID" value="KJY38544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945854.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY38544">
        <property type="protein sequence ID" value="KJY38544"/>
        <property type="gene ID" value="VR44_03430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7903"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY38544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="65" mass="6648" checksum="DFD836B96A882F67" modified="2015-06-24" version="1">MERGPAVFAAGVFLLFGTALLVWTGARAGRRAPVAEGVRPAVAVPLALLAGAGSLALGVWCLQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZ57</accession>
    <name>A0A0F4JZ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945630.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39104">
        <property type="protein sequence ID" value="KJY39104"/>
        <property type="gene ID" value="VR44_02230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5711"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="151" mass="16082" checksum="92D05C351489C756" modified="2015-06-24" version="1">MSLTAPVRLQLTTPPLDEAARQGRFGYALPCPGHEGLAGPDMGAWSGRTLDEVAAEDPEAVRRWLTEPEFAPPGGGESVAALITRTGEHLSGLEPGRHHAVVAQAVVRAAVVSALELPAAAFWRLDVRPDTVTSLSGRAGRWNLHLGRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JZG8</accession>
    <name>A0A0F4JZG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_02250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000033">
        <property type="protein sequence ID" value="KJY39108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945634.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39108">
        <property type="protein sequence ID" value="KJY39108"/>
        <property type="gene ID" value="VR44_02250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5715"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="104"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY39108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="332" mass="34256" checksum="E50269BB74A2EC17" modified="2015-06-24" version="1">MLAEVSATGRRPSDEELDALRDLGEHAAGAGYGLGALLGALAAARAALGGRAAAPGPLPTVVERAVDAVAEGHGRAARLAERQEEAARREFLDALLLGHGAPGPLAEHADRFGLRPAPTHTVAVARARAPYADGGPEVRRLERALAGTALLAVKEGRLICVAPGDDEAVPARFARLAHAGAGPGGLVATGRPHPGPGGAAASYAEALRALDLADRLGLDGPLLRAADLLVYPVLTRDRAALADLVLTVLGPLRSGRGGAVPLLETLTAYFDAGCVSAEAARRLDLSVRALTYRLERIHSLTGHNPANPAHRYTLQTATLGSRLLNWPTDPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K0H1</accession>
    <name>A0A0F4K0H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_00150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945270.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39910">
        <property type="protein sequence ID" value="KJY39910"/>
        <property type="gene ID" value="VR44_00150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.28"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="138" mass="15304" checksum="78D63D67E57EF97D" modified="2015-06-24" version="1">MNCPLHGAGTDPTRLVGRQISRVVASWHICEGERSEAPLDVWLIDSAGESTRITTGSDQCLIVESTPPHEPYDLGEWGRIEVGEDLGEHPFLRHLGQTVESVAEFALPEQGRTHLEIGFPDGRRVRADCHEGDLRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K158</accession>
    <name>A0A0F4K158_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_00885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000012">
        <property type="protein sequence ID" value="KJY39673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945379.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000003_gene4767"/>
    <dbReference type="EnsemblBacteria" id="KJY39673">
        <property type="protein sequence ID" value="KJY39673"/>
        <property type="gene ID" value="VR44_00885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2887"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="207" mass="22945" checksum="16AC58375D9C046A" modified="2015-06-24" version="1">MGRRLVPLTLDNLQDLPRRCRSCVFWELDPVTGEAAVKAGTAELEKESWISAVLLDWGSCGRVVYVDEVPVGFVLYAPPAYVPRAASFPTSPVSPDAVQLITAWIMPGYQGQGLGRVMVQTVAKDLLRRGFKAIEAFGDARWERPACLLPADHLLSVGFKTVRPHPAHPRLRLELRTTLSWKEDVELALDRLLGGARARKEPALRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1D0</accession>
    <name>A0A0F4K1D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S osidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000036">
        <property type="protein sequence ID" value="KJY39026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945651.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39026">
        <property type="protein sequence ID" value="KJY39026"/>
        <property type="gene ID" value="VR44_02365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6763"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY39026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="26864" checksum="966A6BF684E34867" modified="2015-06-24" version="1">MRVALFVTCVNDALYPRTGIAVVRLLERLGVDVDFPAAQSCCGQPQYNTGYRREAEPLLRRTAEAFAGYDHVVTPSGSCAAMVRAHYPRIARLAAREGRGSGLEKLAEDLVPRVHELTEFLVDVLGVTDVGAYYPHTVTYHPSCHGLRTLGLGERPRRLLAAVKGLELVELPGADECCGFGGTFAVKNPDVSAAMAADKTAAARATGAEVLCGADNSCLAHLDGTLRRAGVPLRTLHLAEILASTEEDPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1F0</accession>
    <name>A0A0F4K1F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">VR44_00315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000003">
        <property type="protein sequence ID" value="KJY39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007265907.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000017_gene1031"/>
    <dbReference type="EnsemblBacteria" id="KJY39939">
        <property type="protein sequence ID" value="KJY39939"/>
        <property type="gene ID" value="VR44_00315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.61"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="74" mass="8417" checksum="6BA72ED88689D6E4" modified="2015-06-24" version="1">MATGTKASELRELGNEELVAKLREAKEELFKLRFQAATGQLENNGRLKSVRKDIARIYTLMHERELGIETVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4K1V5</accession>
    <name>A0A0F4K1V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_01965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000027">
        <property type="protein sequence ID" value="KJY39211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945579.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY39211">
        <property type="protein sequence ID" value="KJY39211"/>
        <property type="gene ID" value="VR44_01965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5799"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY39211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="230" mass="25318" checksum="4AFDEB34CD5CD442" modified="2015-06-24" version="1">MRWRSRGRGHIRTDVADVVDELTIPQPFNLDDFCANISAQRKRPLLVLPLDGPADTDLPCGIWVGLDTADLVFYEAGAADILKIQIVLHEIAHMLLGHVSPQLHVSGDADDEPVTVSEHFRRFLARTGDSEKRLDPDPSIAKAMRAEAARIKVAAARPTSSDIELGLSTDRILHLLGRTKFEDRQEEEAETLATLILERASRNEAISTTSDASDVLARLNDALGRPGSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4I4V8</accession>
    <name>A0A0F4I4V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_40810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001853">
        <property type="protein sequence ID" value="KJY15801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY15801">
        <property type="protein sequence ID" value="KJY15801"/>
        <property type="gene ID" value="VR44_40810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY15801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="70" mass="6414" checksum="722BF0CC0259B84B" modified="2015-06-24" version="1" fragment="single">SYGSSAPRPGNGAGGAFDGNPGNGPRGGFDGAPGNGPRGGQGNAPYEGAGTGAGFAPAAPGLPQRPVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IAK7</accession>
    <name>A0A0F4IAK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_39275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001570">
        <property type="protein sequence ID" value="KJY19012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY19012">
        <property type="protein sequence ID" value="KJY19012"/>
        <property type="gene ID" value="VR44_39275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5657"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY19012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="84" mass="9298" checksum="EEDFC3F6A3DBC038" modified="2015-06-24" version="1" fragment="single">AQARLAEARRGFAEAEESARHGQEDAEARAAELVAQARVRQERVGRETDRILREHAEAQEEMRAHMNHVRSSLAALTGRAPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGA7</accession>
    <name>A0A0F4IGA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_38615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001493">
        <property type="protein sequence ID" value="KJY20714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952355.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001493.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY20714">
        <property type="protein sequence ID" value="KJY20714"/>
        <property type="gene ID" value="VR44_38615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5397"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="55"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY20714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="629" mass="67198" checksum="5AC0509EAA3C79C2" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IGX1</accession>
    <name>A0A0F4IGX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_38940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001534">
        <property type="protein sequence ID" value="KJY19901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952417.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001534.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5244"/>
    <dbReference type="EnsemblBacteria" id="KJY19901">
        <property type="protein sequence ID" value="KJY19901"/>
        <property type="gene ID" value="VR44_38940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5504"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY19901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="355" mass="36295" checksum="74F40B81CEA1322B" modified="2015-06-24" version="1" fragment="single">PDARGTRRLTRELDTFAEQNATTTLPVPIALNQPPEPLRLGPSDDAEWAAFAAESVLTAAGALLSDLSRSRRMRAAIDLAWNALASEVAAAAERAPEVESALLPMRARISVRAGLGNLAAGLRPPATGHDNPHYFDDAACVRACVLAVVHPGDPHAAAELAEFDARYTQDGDGVHGARAMAAAVAVALAGADTAAAVDAALEQLPAATEIGRNARHAVKLARTDGEGAFALVPLLEHQIVDHVYSYGIAAAETVPVALALATAARGRAAEAVPAAACLSRVADSAPALAGALTGALGGGDCLPAPWREACRVLSGCALPRLAGTDLVELAALLTRTELTAPTPKPTPPPTPTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ILE1</accession>
    <name>A0A0F4ILE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001406">
        <property type="protein sequence ID" value="KJY22875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952192.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY22875">
        <property type="protein sequence ID" value="KJY22875"/>
        <property type="gene ID" value="VR44_37750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5056"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY22875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="249" mass="25777" checksum="2FB699B611AC2DF7" modified="2015-06-24" version="1">MNAIDRTPADLLRSALAADPGRPLVTFYDDATGERVELSVATFANWVAKTANLLQGDLGAEPGDRLALLLPAHWQSAVWLLACASVGVVVEIGGDPADADLVVSGPDTLEEARACSGERVALALRPLGGRFPQPPAGFADYAVEVPGQGDRFAPFVPVDADGPGLVVGGEELSYAELVERARQDAGERGLGAGARVLSGLGFDGWEGLSAGLYGPLAAGGSVVLCRNLDRLAPEALAQRVESERVTHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IR31</accession>
    <name>A0A0F4IR31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2263 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_37695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001401">
        <property type="protein sequence ID" value="KJY23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045952182.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001401.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY23126">
        <property type="protein sequence ID" value="KJY23126"/>
        <property type="gene ID" value="VR44_37695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5045"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="1">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="274" mass="29487" checksum="8D1362F4F23B527B" modified="2015-06-24" version="1">MSSRLREIARENALIVAAGGYRTRSGRQVSLAAGLAEAKAGTRIYGPNPVIPDGESVRGSRRTVFEVTGESSTVAARRLAGRPALGPVAVLNFASARNPGGGYVRGAKAQEEALCRASALYETLLEAPEYYEVHRAGRSTFYTDRVIHSPGVPVFRDDRGELLETPFRAGFLTSPAPNAGTIRRQEPERAREIPAALTRRAGRVLEVAALHGYGALVLGAWGCGVFRNDPEVVAQAFRRRLTGRFAGTFEHVVFAVLDRDPAPREAFARAFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRB7</accession>
    <name>A0A0F4IRB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_34995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001204">
        <property type="protein sequence ID" value="KJY24565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951679.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24565">
        <property type="protein sequence ID" value="KJY24565"/>
        <property type="gene ID" value="VR44_34995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4048"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY24565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="564" mass="60092" checksum="FEBC7D493C0F36AC" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRE7</accession>
    <name>A0A0F4IRE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001263">
        <property type="protein sequence ID" value="KJY24244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951853.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001263.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24244">
        <property type="protein sequence ID" value="KJY24244"/>
        <property type="gene ID" value="VR44_35935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4345"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="452" mass="50026" checksum="48C7313D1A5A0CF7" modified="2015-06-24" version="1">MATQTRTALVEDLMARFPHVPREAVIKEDLLRGGMAFDESALSGGGADGPGGGDVKPKSYFIFSFDHRTLPELGAAALNRPPEEIVLTGGPYGLRRTVVSVRVNPDSPYVVRGGEDGTLGLYLDGARISDVGLPPMPEYYRHKLSNGKSVMEVAPTIQWGYLIYLTVFRVCQYFGAKEECQFCDINHNWRQHKAAGRPYTGVKPVEEVLEALEIIDRYDTAGTSRAYTLTGGSITSQVGGRDEADFYGHYAQAIEERFPGRWIGKVVAQALPRDAVQRFHDHGIRIYHPNFEVWDRRLFQLHCPGKERYVGRDEWHRRILDSTEVFGPRNVIPNFVAGIEMAEPFGFTKVGEAIESTTEGLRFFMSHGVVPRFTTWCPEPTTPLGKANPLGAPLEYHIRLLEAYRATLEEFGLSSPPGYGPAGPGRAVFSVSSFMDSLEGLEEPAQDAPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRH7</accession>
    <name>A0A0F4IRH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_35845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001257">
        <property type="protein sequence ID" value="KJY24274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24274">
        <property type="protein sequence ID" value="KJY24274"/>
        <property type="gene ID" value="VR44_35845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4326"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY24274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="79" mass="8142" checksum="85270A9E81808F77" modified="2015-06-24" version="1" fragment="single">ERDAGEEVVLVVEGAAQGVESVPGVRVESASGSGDDLIVELAAAHADRPCTVVTADRALRERVRAYGVTCAGPRTVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IRU0</accession>
    <name>A0A0F4IRU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_34440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001175">
        <property type="protein sequence ID" value="KJY24735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951576.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001175.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24735">
        <property type="protein sequence ID" value="KJY24735"/>
        <property type="gene ID" value="VR44_34440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3868"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY24735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="352" mass="36578" checksum="8D2E6F762CE575C3" modified="2015-06-24" version="1">MTTTHAHTHSHARARGRDRRVYLRSHPLLFGLLAATRGRGVRRLGGTVLVHDAEAYRQALTRLPLDRTAAGTTGGAAREALRGAGGVLFDQEGGGHRADRVERLREVWRPLLVRGFAPLGRGGEVDVVALARELAGSVVCALLECPADPRAVAEAAAVAAAASVRDHLPGLPRPGAGARAAGAAERLRGLLADGDPLSAMLNTTVAALPRAVAWCADAGLWGQAADAELRPRLAEELLRVTAASPVLPRVAAADGLVGGCPVRGGDRLLLVARHAAQAHGRDPDGRSPAGPGVARLVFGAGPHTCPGARLATAQLADTLEALAPHRPVVTRARVDRRSALPGWRELRLAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4ITU1</accession>
    <name>A0A0F4ITU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_33570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001126">
        <property type="protein sequence ID" value="KJY25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25064">
        <property type="protein sequence ID" value="KJY25064"/>
        <property type="gene ID" value="VR44_33570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3596"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="362" mass="36997" checksum="4096D5D6920D55E6" modified="2015-06-24" version="1">MGRVSETDRPRPRRRGPLRAAVGLAVLLAVIGYVLVHHYSNGGAGAPYCEVTAKGSAGGSGGAVQTYGMSPEQASNAATIAAVGISKGLPDRAVTIALATAMQESGLRNLDHGDRDSLGLFQQRPSQGWGTPEQIMDPVYSAGIFYDRLVEVKGYTRLPLTVAAQRVQLSGFPQAYAKHEPDATVVTAAFGEGETTATLTCSGPAPAKGDPEKVRTELARAFGKEALSAGRPALHAGAKTGESPSPKAVASPSAGSAGAAGGAAAGPSQPAAVPEAEVDLWLKDGGGAAEARRGRAMAHWAVARSRDLGIARVSYDGSVWAAGQNRGAWQRKGAGGTKGNAAPDPYEAVPGQVRIFLPRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUP2</accession>
    <name>A0A0F4IUP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001087">
        <property type="protein sequence ID" value="KJY25359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951262.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25359">
        <property type="protein sequence ID" value="KJY25359"/>
        <property type="gene ID" value="VR44_32715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3356"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="251" mass="27705" checksum="A9EAA253439E1682" modified="2015-06-24" version="1">MAIAHRRIGSGPVRVIVLHDWFGTSANWGSVLDYLDPEGFSYAFLDYRGYGTRRDVPGRHTLPEIADDVLELADELGWDTFSLLGHSMGGKAAQQVLVRAPERIEKLIGLCPVPAAPYEMDDATHALFYGAAEDPDKRRTILDLVTGHRASRHWLDRMVAHSLAVSRPEAFAGYLADWQPRDLSSAVKGNTVPVLVLVGEYDLALTADVMRATWQVWYPDCALVTVPGAGHYPPHETPVAFVTEVEAFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IUX7</accession>
    <name>A0A0F4IUX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">VR44_32545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="JZWV01001075">
        <property type="protein sequence ID" value="KJY25424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951228.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001075.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000020_gene7172"/>
    <dbReference type="EnsemblBacteria" id="KJY25424">
        <property type="protein sequence ID" value="KJY25424"/>
        <property type="gene ID" value="VR44_32545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3321"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJY25424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="282" mass="30413" checksum="2268B7879150E56A" modified="2015-06-24" version="1">MLRIAVPNKGSLSGPASEMLHEAGYRQRKESKELVTVDPDNEVEFFYLRPKDIAIYVASGKLDIGITGRDLLLDSGANAEEILPLNFGRSTFRYATKPGTANGPEDFGGMTIATSYEGIVAKHLADLGVDASVVHLDGAVETAIELGVAQVIADVVETGTSLRNAGLEVIGEPILKSEATVIRRTGAGDDDPKVAQFLRRLQGVLVARSYVMMDYDCRAEHLERAVALTPGLESPTISPLHNEGWVAVRAMVPAKEAQRIMDDLYELGARAILTTSIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IV31</accession>
    <name>A0A0F4IV31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_35095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001212">
        <property type="protein sequence ID" value="KJY24526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951697.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001212.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24526">
        <property type="protein sequence ID" value="KJY24526"/>
        <property type="gene ID" value="VR44_35095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4096"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470168" evidence="3">
        <location>
            <begin position="35"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY24526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="545" mass="59247" checksum="2F3940710654BE9E" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IVT4</accession>
    <name>A0A0F4IVT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_32145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001056">
        <property type="protein sequence ID" value="KJY25568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951155.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25568">
        <property type="protein sequence ID" value="KJY25568"/>
        <property type="gene ID" value="VR44_32145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3148"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY25568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="619" mass="64483" checksum="20A878BA1F3A4933" modified="2015-06-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IW42</accession>
    <name>A0A0F4IW42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_34010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001150">
        <property type="protein sequence ID" value="KJY24906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951498.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001150.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY24906">
        <property type="protein sequence ID" value="KJY24906"/>
        <property type="gene ID" value="VR44_34010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3728"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470309" description="Lipoprotein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY24906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="293" mass="31192" checksum="5CF2F41E26CF35F9" modified="2015-06-24" version="1">MSAATPRRRTALALTTTVTALALLVSGCGLGGPEGKRIRVGVSGDSPEWDVLAKEAKKEGLTVEPVVFDDYSLPNKALAAGDIELNAFQHLVFLAQSNTANKTDITPVAATTVVPLGLYSGKHKQLSDLPDGASIALPNDPSNQGRALHVLEQAKLIGLKPDAGLFATPDDITDNPRHVKITPVNAQQTPRTLQDADAAVINDGVAQLAGIDAKTALFKDDPASPQALPYLNVIAARADRKDDADFQKIVKLYASKAVQDEVRRTSNGTAHHIELPAPELRTELDRITKQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IWL4</accession>
    <name>A0A0F4IWL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_30090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000941">
        <property type="protein sequence ID" value="KJY26420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950778.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000941.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26420">
        <property type="protein sequence ID" value="KJY26420"/>
        <property type="gene ID" value="VR44_30090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2421"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY26420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="442" mass="46317" checksum="C423845EA8EB498E" modified="2015-06-24" version="1">MGSSTRAVRDTPGRRAAARRRLVAAAFLLPALVLLGALVVQPIGFSLYRSLFDRSGDTFVGAANYTAVVRDPAIRTALRNTAVWVVVAPAVATGLGLVFAVLTERVRWGTAFKLLVFMPMAISMLAAGIIFRLVYDHDPHRGVANAVVVGVHDTFAPASAFPKARPGRDSPLEPAGDGAFVTREPVRAGVPALLPLVGVAPEALPKGARTAAGARPVPGEVTGTVWQDFTRGGGGAVNAVDPTETGLAGMRIEAVKDGRTVATATARADGTFTLPAAADGARLRLPASNFREAFAGVEWLGPVLVTPAVIGAYVWMWAGFAMVLIGAGLAAVPRELLEAARVDGAGEWQVFRRITVPLLAPVLVVVLVTLVINVMKIFDLVFVIAPGAVQDDANVLALQLYRTAFGTDADQGLGSAIAVLLLVLVVPVMLVNIRRIRRGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXN0</accession>
    <name>A0A0F4IXN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_29260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000905">
        <property type="protein sequence ID" value="KJY26767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY26767">
        <property type="protein sequence ID" value="KJY26767"/>
        <property type="gene ID" value="VR44_29260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY26767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="95" mass="9751" checksum="CA972C007C02E4FB" modified="2015-06-24" version="1">MDGAGRADPRSAAKALRGSLGSLGPGAQDFEGTLMPAVDLVARMVVDGRLVAGVHPHAGALAVGDDIEWLFVGVSVLGGIRDDRESPTSSINSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXP0</accession>
    <name>A0A0F4IXP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">VR44_32530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="JZWV01001075">
        <property type="protein sequence ID" value="KJY25421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25421">
        <property type="protein sequence ID" value="KJY25421"/>
        <property type="gene ID" value="VR44_32530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3318"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="214"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="208"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJY25421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="419" mass="45000" checksum="0E39B2598490EC6E" modified="2015-06-24" version="1">MTPVLKPVPDPVESGAEESYRLDPVEQAIRDIAAGRPVIAAEKATPEIIAFMMSECRGLICAPMEGPELDRLELPQMVQHNTESMKTAFTVSVDASAAHGVTTGISAADRATTLRLLANGTSEPGDFVRPGHIFPLRAKPGGVLVRNGHTEAAVDLARLAGLRPAGAIVEIAGEDGVMLRLPELIPFARKHGLTIISIEDLIAYRRSAEPTVRREAEVSLPTAAGEFTAYGYRSTVDGVEHVALVHGEVGDGRDVLVRMHSECLTGDIFQSQRCDCGPQLQAAMARVQAEGRGVIVYLRGHEGRGIGLLSKMRAYELQERGRDTLDANLELGLPADARDYGAGAQILADLGVRTVRLMTNNPDKAAALEDHGISVAGREPMPVQAGEHNLRYLRTKRDRMGHDLPWLEGAVPTSACGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IXZ2</accession>
    <name>A0A0F4IXZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_32250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01001061">
        <property type="protein sequence ID" value="KJY25526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045951175.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01001061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY25526">
        <property type="protein sequence ID" value="KJY25526"/>
        <property type="gene ID" value="VR44_32250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3172"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY25526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="148" mass="16325" checksum="D9423A80F9772FF2" modified="2015-06-24" version="1">MSTTATRRPAKLELLELLAAIGTAQWRDFAAAAARYGLTSTQAKVLAQLDGPVPMRGLASLLACDASNVTGIVDRLEARGLVRREPEPRDRRVKNVVATEEGRETMRRVREEMQATHGALDTLDEVEGATLYALLERLRPAMERRAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4IZP0</accession>
    <name>A0A0F4IZP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_27410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000830">
        <property type="protein sequence ID" value="KJY27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950293.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000830.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5363"/>
    <dbReference type="EnsemblBacteria" id="KJY27472">
        <property type="protein sequence ID" value="KJY27472"/>
        <property type="gene ID" value="VR44_27410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1649"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY27472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="255" mass="26363" checksum="AEB7BAF350B51A46" modified="2015-06-24" version="1">MSAGTFTPRPGAAPVSRMIWAQTALETRMLLRNGEQLLLTVIIPALLLTLFSAVDIVDTGTGKSVDFLAPGVLALAVMSTAFTGQAIATGFDRRYGVLKRLGASPLPRWALMAAKTLSVLVTEVLQVALLTVIALALGWSPHGNPLSVAVLLLLGTAAFSGLGLLMAGTLKAEVTLAAANLVFLLLLVGGGVIVPLEKFPGAVQAVLGLLPISALSDGLREVLRNGAALPWGDAAVLAGWAVLGLGAAAKWFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J007</accession>
    <name>A0A0F4J007_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_28095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000856">
        <property type="protein sequence ID" value="KJY27234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950414.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000856.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000009_gene3078"/>
    <dbReference type="EnsemblBacteria" id="KJY27234">
        <property type="protein sequence ID" value="KJY27234"/>
        <property type="gene ID" value="VR44_28095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1862"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY27234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="216" mass="23040" checksum="DD61ACD9649F9171" modified="2015-06-24" version="1">MPFREINSKMVEAQVIPGQRMYSQRGAMLAYRGEVSFTPSITGGQGGVMGMIGRRVANEQTPLMEVEGSGTVMFGHGGHHIQVINLQGDTLYVEADRLLAFDGTLQQGTMFMGSQGGVMGMVRGQVTGQGLFTTTLKGHGAVAVMAHGGVIELPITPNRPVHVDPQAYVAHHGDVRNKLSTALGWRDMVGRGSGEAFQLELSGQGAVYVQASEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J065</accession>
    <name>A0A0F4J065_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_27955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000851">
        <property type="protein sequence ID" value="KJY27289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950388.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000851.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000031_gene214"/>
    <dbReference type="EnsemblBacteria" id="KJY27289">
        <property type="protein sequence ID" value="KJY27289"/>
        <property type="gene ID" value="VR44_27955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1840"/>
    <dbReference type="eggNOG" id="COG0354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="322" mass="34765" checksum="863DC0A45857A485" modified="2015-06-24" version="1">MTSSPLLHLPGAVAAEGRDEGVAAHYGELYGEQRALADGRGFVDLSHRGVVTVTGQDRLSWLHLLITQHVTELPPGQATEALILSANGHIEHQLLLVDDGETTWAHVEPGTQEALIAYLESMKFFYRVEVADRTADFAVVHLPAGSIAELDKELVVRETPYGRDVFLPRERLEAFAAAHGPAAGLLAYEALRVEAHRPRLGLETDHRTIPHEIGLIGTAVHLQKGCYRGQETVARVHNLGKPPRRLVFLHLDGSEVLLPAHGAPVRLAADGEDGRQLGFVTTAVRHHELGPIALALVKRNVPVDAPLLAGTTPAAQEVVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J162</accession>
    <name>A0A0F4J162_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_27415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000830">
        <property type="protein sequence ID" value="KJY27473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950294.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000830.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5364"/>
    <dbReference type="EnsemblBacteria" id="KJY27473">
        <property type="protein sequence ID" value="KJY27473"/>
        <property type="gene ID" value="VR44_27415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1650"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY27473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="32663" checksum="466778EF405F8D8B" modified="2015-06-24" version="1">MSNDPAVEIRGLVKRYGSKTAVDGLDLTVPGGAVTAVLGPNGAGKTTTIETCEGYRRPDAGTVRVLGLDPVADARALRPRTGVMLQSGGIYSGARAVEMLRHMAKLYADPLDVGALVERLGLGGCGRTPYRRLSGGQQQRLSLAMAVVGRPELVFLDEPTAGLDPQARRATWDLVRELRADGVAVVLTTHHMDEAEQLADEVAIVDAGRVIAHGSPEQLCRGGAENTLRFSGRPSLDLASLLKALPDGTQAAELTPGSYRVTGDVDPQLLATVTSWCAQHGVMPSSLTVERHTLEDVFLELTGKELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1F6</accession>
    <name>A0A0F4J1F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000764">
        <property type="protein sequence ID" value="KJY28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950041.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000764.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28102">
        <property type="protein sequence ID" value="KJY28102"/>
        <property type="gene ID" value="VR44_26050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1365"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="140" mass="15253" checksum="E042DB866262B9B3" modified="2015-06-24" version="1">MSDRFTTRILRLTTGRAETVTDLTRDCERFLTEEAAGRDGLLNVFVPHATAGIAVIETGAGSDEDLLAALATLLPADDRWHHRHGSPGHGRDHVLPAFVPPHATLPVVGGRLQLGTWQSVCLVDTNRDNPDRQVRLSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J1G5</accession>
    <name>A0A0F4J1G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">VR44_26950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000805">
        <property type="protein sequence ID" value="KJY27709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950207.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000805.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000002_gene5238"/>
    <dbReference type="EnsemblBacteria" id="KJY27709">
        <property type="protein sequence ID" value="KJY27709"/>
        <property type="gene ID" value="VR44_26950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1552"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="349" mass="37100" checksum="4FC1535303CE1EFB" modified="2015-06-24" version="1">MTLAYIPSPSTGVLHLGPIPLRGYAFCIIIGVFVAVWLGNKRWIARGGKPGTVADIAVWAVPFGLVGGRLYHVITDYQLYFGEGRDWVDAFKIWEGGLGIWGAIALGAVGAWIGCRLRGIPLPAWADALAPGIAIAQAFGRWGNWFNQELYGRPTDLPWALKISEGPNRVAGLYHPTFLYESLWCLGVAALVIWADRRFRLGHGRAFALYVAAYCSGRVWIEYMRVDEAHHILGVRLNVWTAIVVFILAVVYFVLSAKLRPGREEVVEPEPSGGSGDTAGSDRDGADAAKPAADAKAEPEGSVGADAAKPAGAGAGAEAPASADAAKPEADKAEAKPVGLTKGPEADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J2M2</accession>
    <name>A0A0F4J2M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000717">
        <property type="protein sequence ID" value="KJY28577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949846.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000717.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28577">
        <property type="protein sequence ID" value="KJY28577"/>
        <property type="gene ID" value="VR44_25025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="13154" checksum="E74298A8A2630022" modified="2015-06-24" version="1" fragment="single">MRLLLTSDTHLPARGKHLPDALLDEVDAADVVIHAGDWTDEATLDLLEARARRLIGVYGNNDGPALRRRLPEVARASLAGLRFGVVHETGGAAGRERRCAERFADLDVLVFGHSHIPWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J392</accession>
    <name>A0A0F4J392_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_27780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000843">
        <property type="protein sequence ID" value="KJY27376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27376">
        <property type="protein sequence ID" value="KJY27376"/>
        <property type="gene ID" value="VR44_27780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1794"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY27376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="201" mass="21457" checksum="EBB1A0F231079A12" modified="2015-06-24" version="1" fragment="single">GYAVTPERRAGAVADTFLGEGAGCVTALVLLALIGLYSLLKKTGAPEAALTACIVLFLAALCYGALIALVQWASGVVVDVLIVLLAVLTLPGLLFPGYRRALRRRMGGGGPETERGWVPATALAGVWYQPDPRGGDVVTVRLADGSVTAFVPAPDRARDLYDRFDALLRSTRPAPWPPQQPQPWQGHQPHQPYPYPGHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J3Z6</accession>
    <name>A0A0F4J3Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000734">
        <property type="protein sequence ID" value="KJY28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949920.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000734.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000010_gene1612"/>
    <dbReference type="EnsemblBacteria" id="KJY28423">
        <property type="protein sequence ID" value="KJY28423"/>
        <property type="gene ID" value="VR44_25415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1179"/>
    <dbReference type="eggNOG" id="ENOG5033TII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="166" mass="17935" checksum="4B1FD776B6DFABE4" modified="2015-06-24" version="1">MSFLRRHRAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQGVFLRYDLFGGRGPAMIIGNLPEGSPARDLGEGQVPFEVAQLLDALENDEEVEVTGTEDCPVMQGDNLLIVRKVKLSEGRISCVQFDRSDNVLVTIASWDRPITDDLYALLKPLPAELFQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4B5</accession>
    <name>A0A0F4J4B5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_25090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000720">
        <property type="protein sequence ID" value="KJY28543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28543">
        <property type="protein sequence ID" value="KJY28543"/>
        <property type="gene ID" value="VR44_25090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1108"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY28543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="468" mass="49737" checksum="A20DE1CCE1262747" modified="2015-06-24" version="1">MELSEDGGSLYERLTSGIRTAIVEGRLGPGHLLPPSRALAAELGCSRWVVNEAYTQLAAEGQLQTRQGSGTRVTAHPTRPKPDRAPTTRRAPAAPPVVADLRPGTPDVAAFPAPGWTRSLHHVLATADWEPSVFPQAAGTQRLREVVAAHLRRVRGLAVEADEVLITCGTSHGVSLVARVLAARGVPHLAVEDPGWPRLHQVAAAAGLPTEPVAVDAEGLDVEALTRTDARAVLCAPAHQFPTGAALSPARRRALLTWAAQHAAVIVEDDYDAEFRYDRRPVGALAGLDRNLVVYLGSVSKTLHPGLRLGWMVPPPALRQPLLDALDTAAAGPSTLDQLTFARLAGTGGYDKHLRRVRKTYRARRDALVTTLGSHAVIRDCGPVRGIAAGLHLLVPLPSALDDHTIVEHLADRGIATAALSGYTTRHQPPALVIGYGRLAPSRAQWAAEQIAEVLLDQLPTPRSGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4C8</accession>
    <name>A0A0F4J4C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949813.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28674">
        <property type="protein sequence ID" value="KJY28674"/>
        <property type="gene ID" value="VR44_24870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.974"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="334" mass="36471" checksum="5F82ED37F6E0A73F" modified="2015-06-24" version="1">MPLVPPRVSPRRLRRLVAGTAAVLGVLGVLLWWLRPFGEPALAGKLTFSTGVRTGVYHRYGQLLEQALAQDMPGVKVRLETSEGSQQNLQRVASGEADFTIATADAVAKYRADGKPGAEQLRGCARLYDDYVQLVVPAGSPVQSARDLRGKRVAIGQEGSGVRLISDRLLRAAKLDPAHDITPVAIGIDTMPAELQAGRIDAFFWSGGLPTNAVRELSERFDIRLVQLGDLVEQLQASGSPARYYRAAVMPQDAYARARNTSSVATLAVPNLLVTKEGTDARLTEQFTRTVILSRDRIGHEVHAAQLVDLRTAIYTDPLDLHEGARRYYRSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4G5</accession>
    <name>A0A0F4J4G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Branched-chain alpha-keto acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_26650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000793">
        <property type="protein sequence ID" value="KJY27826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY27826">
        <property type="protein sequence ID" value="KJY27826"/>
        <property type="gene ID" value="VR44_26650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY27826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="154" mass="15454" checksum="C5EB22E29FBC33E7" modified="2015-06-24" version="1" fragment="single">MTIREFKMPDVGEGLTEAEILKWYVQPGDTVTDGQVVCEVETAKAAVELPIPFDGVVHALLFEEGVTVDVGQVIISVETGGAGGAEEPAAAGVQASVEVTEAAAAAAAPAAPAPAAPAEEPAARQPVLVGYGVSQSSTKRRPRKAPAAAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J4T3</accession>
    <name>A0A0F4J4T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000700">
        <property type="protein sequence ID" value="KJY28824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949748.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000700.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28824">
        <property type="protein sequence ID" value="KJY28824"/>
        <property type="gene ID" value="VR44_24485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.892"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="308" mass="32859" checksum="9AFC604C7634CABB" modified="2015-06-24" version="1">MGRIGVDLYPLKTGVPLAEADTFGKFLGGSPANVAVAAARLGRRTAMISRTGADPFGAYLRGELREFGVDDRWVEEVAHYPTPITFCEVFPPDRFPLYFYRLPKAPDLEIEPDEIDREAVRDARVFWMTGTGLSAEPSRAATLAALEARSKSGTTVFDLDWRPMLWDAGPPRPWYERALALTTVAVGNAEECEVATGEGEPYAAARALLAAGVELAVVKRGPEGVLAVHRDGTAVEVPPVPVTVVNGLGAGDAFGGALCHGLLAGWELERVLRYANAAGAIVASRLACSTAMPFAHEVEEVLDRAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J569</accession>
    <name>A0A0F4J569_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_26185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000767">
        <property type="protein sequence ID" value="KJY28056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045950063.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000767.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28056">
        <property type="protein sequence ID" value="KJY28056"/>
        <property type="gene ID" value="VR44_26185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1394"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smoa_sbd" evidence="1">
        <location>
            <begin position="146"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="435" mass="46868" checksum="DD247671954265D9" modified="2015-06-24" version="1">MRRILVVGAGQSGLQLALGLQAKGYEVTLMSNRTADEIRTGRVMSTQCMFDSALRHERDLQLNFWERQAPRIQGLGVSVAAPDGGRAVDWLGRLKGYAQSVDQRVKMAGWLDVFVQRGGQLVIHGASVADLDYFSRAYELVLVAAGKGELVSMFDRDEARSPYDSPQRALAVAYVHGLAPRPEHPDTDAVRCNLVPGVGELFVMPTLTNSGRADILFWEGLPGGPLDVFRGVNDPGEHLELTLELMEKFVPWEYARATKVELTDAGGTLAGRYAPVVRKPIGRLPGGGLVLGVADVVVANDPITGQGSNAAAKCAASYLSSILMHGDKPFDEAWMKATFDKYWFTTGKPVTQWTNAMLGAPPEHVLNLIGAAGQYQRVADRFANGFDNPADFDAYFYDPEDTEDYLAEVAEAAEAVEVAEAGEAAEAAAGSSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J660</accession>
    <name>A0A0F4J660_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VR44_23425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000660">
        <property type="protein sequence ID" value="KJY29253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29253">
        <property type="protein sequence ID" value="KJY29253"/>
        <property type="gene ID" value="VR44_23425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.627"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJY29253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="241" mass="24850" checksum="3E69B6401CA80A94" modified="2015-06-24" version="1">MEQHHESGAHFAFTDRWGGVSAVPYEELNLGGAVGDDPAAVRANRAAAAKELGIDPDLVVWMNQVHGRDVAVVDGPWGPAADIPSVDAVVTARRGLALAVLTADCTPVLLADPVAGVAAAAHAGRPGLVAGVVPAAVEAMVGLGADPARIVARTGPAVCGRCYEVPAEMREAVAAVVPAAWAETSWGTPAVDVVAGVHAQLAEAGVPQGHRSPVCTLESRDHFSYRRDRVTGRLAGYVWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6D1</accession>
    <name>A0A0F4J6D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000730">
        <property type="protein sequence ID" value="KJY28456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949901.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000730.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28456">
        <property type="protein sequence ID" value="KJY28456"/>
        <property type="gene ID" value="VR44_25340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1165"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="261" mass="27774" checksum="9576A3B09CC7E693" modified="2015-06-24" version="1">MTSVPVPGLAAVSPLLTRLAAERATGALLRDRGTLFLEDGRIVHAESPSTPGLDVLLTTGGGLAPERWNEALSEAGATRQVARFLVDSGGLAGGEMEICHLAAIFDAAFFALSPGSGPSRFRRGATHWIGSMRSVPAAAVERETRRRRELLDAVWPYPQLDTAPVVPRPAAPGQIVTARQRALLARADGVRTPADLAWVLGRPAFHTLLDVRRLAAAGLVETPHTRPAPPPAAPLPDWMTQAQSPDVALLRRLRDALEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6K0</accession>
    <name>A0A0F4J6K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_25105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000720">
        <property type="protein sequence ID" value="KJY28541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28541">
        <property type="protein sequence ID" value="KJY28541"/>
        <property type="gene ID" value="VR44_25105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1113"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY28541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="33" mass="3599" checksum="F9153CD3AB5337DD" modified="2015-06-24" version="1">MVVKLGVWVSNTESRRDKPTTDQLAALAKLGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J6W4</accession>
    <name>A0A0F4J6W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen triple helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_24855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000710">
        <property type="protein sequence ID" value="KJY28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949810.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000710.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY28671">
        <property type="protein sequence ID" value="KJY28671"/>
        <property type="gene ID" value="VR44_24855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.970"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="81" mass="8315" checksum="A66C26B1CD754C34" modified="2015-06-24" version="1">MGLLDNLKAKLAPAKDKVGDLAQKHEGRIGEGLDKVAKVVDSKTHGKYSDRITSSTDKAKGALGKVAHKDAPGGPTPPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J731</accession>
    <name>A0A0F4J731_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_22475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000629">
        <property type="protein sequence ID" value="KJY29619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949377.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000629.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29619">
        <property type="protein sequence ID" value="KJY29619"/>
        <property type="gene ID" value="VR44_22475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.384"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="209" mass="22651" checksum="CDF141F46B6BA82B" modified="2015-06-24" version="1">MTSTPQTAARRSKISPEREQEFYDAVLDQLREHGYEALTMEGVAARACCGKSTLYRQWKTKPQLVAAALRASRARRGERTLADVDTGNLAEDLREAARIAAGTSGRDTRLTQALGNAVLSDEELQRALREALVEPELAAFDTIVARAVARGEIAADHPAVEFLAAQLMGVLRIRPVLEGRYADADYLVRFVDAALLPALGIGPGDHPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J8U3</accession>
    <name>A0A0F4J8U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_20010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000552">
        <property type="protein sequence ID" value="KJY30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948920.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000552.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30600">
        <property type="protein sequence ID" value="KJY30600"/>
        <property type="gene ID" value="VR44_20010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8624"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="194" mass="20592" checksum="32781EF8E5096408" modified="2015-06-24" version="1">MAAWWPGRGRFERAREAERERLLARLGERTAEPGETGDPRLVDASAGRGEGGRGTADGFTPMLVEYYAYGLTQARASFATSQWFAGVGAAVLLFGIALGVWKAESGGEAYVGVVTSSVGVVVTLVGQLFHRRADAALRHMAAQTASLREDRRAAEGTRQAIALLEEVADPELRGRLQAGLIIRLSGAELPPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9D1</accession>
    <name>A0A0F4J9D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_19475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000536">
        <property type="protein sequence ID" value="KJY30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948825.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000007_gene3242"/>
    <dbReference type="EnsemblBacteria" id="KJY30805">
        <property type="protein sequence ID" value="KJY30805"/>
        <property type="gene ID" value="VR44_19475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8504"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="263" mass="27720" checksum="B078D2C7842DBB54" modified="2015-06-24" version="1">MTDRTEEIVCRRLVGRTAVITGAGSGIGLATARRLASEGANVVCADIDPLAGKAAAEEVGGTFVQVDVTDKEQVDALFKTAFDTYGSVDIAFNNAGISPPDDDSILTTELDAWRRVQDVNLTSVYLCCKAALPYMQRQGRGSIINTASFVAIMGAATSQISYTASKGGVLAMSRELGVQFAREGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPLGRFAEPTEIAAAVAFLASDDSSFINATDFLVDGGISGAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9D2</accession>
    <name>A0A0F4J9D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_22555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000633">
        <property type="protein sequence ID" value="KJY29571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949403.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000633.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29571">
        <property type="protein sequence ID" value="KJY29571"/>
        <property type="gene ID" value="VR44_22555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.401"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY29571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="16143" checksum="AC5AF9C6B13202D1" modified="2015-06-24" version="1">MGGPALFIGTDTTYVALVRPRLDPADPEVREAAEQAGVSPEEFAGPGNVWALMWEQDGVDGGGFELPGLRDAEAEDFADRLLAELSFESGPFTVGAGEVLHIQAYPAAETCRFVSVITPPEGEELAPVTLDVPAVDADALRADLEDFRRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9E3</accession>
    <name>A0A0F4J9E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_19185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000526">
        <property type="protein sequence ID" value="KJY30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948769.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000526.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY30972">
        <property type="protein sequence ID" value="KJY30972"/>
        <property type="gene ID" value="VR44_19185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8443"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470243" evidence="1">
        <location>
            <begin position="24"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="78"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="519" mass="55813" checksum="52659D630A477010" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4J9N3</accession>
    <name>A0A0F4J9N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_20470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000563">
        <property type="protein sequence ID" value="KJY30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949003.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000563.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000065_gene6650"/>
    <dbReference type="EnsemblBacteria" id="KJY30443">
        <property type="protein sequence ID" value="KJY30443"/>
        <property type="gene ID" value="VR44_20470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8805"/>
    <dbReference type="eggNOG" id="COG3879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="280" mass="30047" checksum="7E4F0DB398569CA5" modified="2015-06-24" version="1">MSGDNVPQGDPGAEPEPKDAGAPRPDAPLPGAVRPEPEPEQTGRQRLAAGLWPPRFSRAQLIVALLLFVLGLGLAIQVRSNSDSSAPLRGARQEDLVRILDELDGRTKRLEDEKQKLDDQRKELQSSSNQAEEARKQTLERERQLGILAGTVAAQGPGITLRITDAKGQVRSDQLLDTLQELRAAGAEAIQINGVRVVAGSYFSDEGGGVAIDGKKITQAYEFRVIGKPQDLEPALNIPGGVVQTMEKEQATVAVTRSAKIVVDALRAAKQPDYARSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA48</accession>
    <name>A0A0F4JA48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_21810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000610">
        <property type="protein sequence ID" value="KJY29851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045949254.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY29851">
        <property type="protein sequence ID" value="KJY29851"/>
        <property type="gene ID" value="VR44_21810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.241"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470754" evidence="1">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY29851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="183" mass="18676" checksum="B831D9FCAF59966F" modified="2015-06-24" version="1">MTVRVLALVGSLRAGSHNRQLAEAAVKHAPGHVSVEIHEGLADIPFYNEDIDVEGSVPGAAADLRAAVAGADALLLVSPEYNGTIPAVLKNAIDWLSRPYGTGAITGKPVAVIGTAFGSYGGVWAQDEARKSAGIAGGAVLEEAKLSVAGSVTRFAETHPGDDTEVATAVLQVLEQLATKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JA57</accession>
    <name>A0A0F4JA57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VR44_18990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000520">
        <property type="protein sequence ID" value="KJY31065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31065">
        <property type="protein sequence ID" value="KJY31065"/>
        <property type="gene ID" value="VR44_18990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8402"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJY31065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="218" mass="23628" checksum="C1BEEC3B5015D4E8" modified="2015-06-24" version="1">MRVARINAAYVAKVPGFQVSGEAHSAAAALEFLTTRPVDLVLLDHYLPDGTGLDLVRRLRQLGRHTDVIMVTAARDLTTVQAAMRLGALQYLVKPFTFAGLRAKLEAYAALRRSLSGGGEAEQAEVDRIFGALASAGTPNELPKGHSPTTAELVRRVLRTAEGPLSTQQIADRAGISRQTAQRYLKLLDRAGRVSLALRYGETGRPEHRYTWVPSAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAH7</accession>
    <name>A0A0F4JAH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000511">
        <property type="protein sequence ID" value="KJY31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31195">
        <property type="protein sequence ID" value="KJY31195"/>
        <property type="gene ID" value="VR44_18705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8351"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="240" mass="26432" checksum="FCFF4AF5FEE624DE" modified="2015-06-24" version="1">MRVLLLHGLAGGANVWDALLEHTVGSPHEVWTAELPWRAEGVPGWTGHSPAHWVRQATGRVPGGPDVVIAHSFGANALLALLDEEPEGGPAPRPRAVVLVSPFYRPRPEAFGWDAISYYLNDFDRILADGLRVRSGGRLPDDLRREMALKVRDRIGPYGWLSFFDTYLRTPDLRTDRMTMPCLIVGGERDFASFPADSEALCAALPYAKAEILPGCGHFAMTERAAEFARLTEDFLQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JAV2</accession>
    <name>A0A0F4JAV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000491">
        <property type="protein sequence ID" value="KJY31477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948550.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000491.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31477">
        <property type="protein sequence ID" value="KJY31477"/>
        <property type="gene ID" value="VR44_18050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8156"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="286" mass="31081" checksum="41B0540C4FD1B626" modified="2015-06-24" version="1">MRIATTIFLTDRTVSPTHLARTLEERGFAGLYLPEHTHIPVSRTTSAPMGGELPEQYGRTLDPFVALAQAAAVTRRLHLGTGITLVAQHDPIGLAKQAATLDHLSNGRLTLGIGYGWNVEEAADHGVDWPTRRERVRSHMALMRALWSPKPTAYESPYGSVQASLAYPKPATPPRELPAGERLHGPRTLIGGAAGPKLFAAVADHADGWLPIGGGGLTENLPVLRRVWEDAGRDPKTLQVVPYAVQPTPGKLAHYAKLGIEEVVLQLPSAREEEVLRTLDDYAQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBL8</accession>
    <name>A0A0F4JBL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_18825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000515">
        <property type="protein sequence ID" value="KJY31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31133">
        <property type="protein sequence ID" value="KJY31133"/>
        <property type="gene ID" value="VR44_18825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8376"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470908" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="72" mass="8130" checksum="5ED615EB9CAF793B" modified="2015-06-24" version="1">MRTFSASFLVSRWFMTAPTAAPTMNGIRLGTLRNIRFMICWRSSRFIWPPSAALTVVGLVRSIPRSSVQAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBP7</accession>
    <name>A0A0F4JBP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_17785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000480">
        <property type="protein sequence ID" value="KJY31615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31615">
        <property type="protein sequence ID" value="KJY31615"/>
        <property type="gene ID" value="VR44_17785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8099"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="271" mass="27483" checksum="EF95A54ACA2EE897" modified="2015-06-24" version="1">MLGRLTAQAREGAQLHHARVELAEALQREMLPASLPVLPGLRTAARYAPAQHGLDIGGDWYDGFRLPEGALAFSIGDVQGHDVAAAAFMGQVRVCLRAVSAVVSDPGEVLGRANDVLLSMDCELFATCSLLRFDPSTGELQGARAGHVPAVWATVDGRHGIAEDAGGPPLGLVPGAGYGVTRRRLTAAGSIVLLTDGVVEGPSFPIETGLERVSRIVREGAGGDPGELAAEVMKVADSTGHADDAAVLVLSHDGPGAGAGPGNGPGTGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JBP9</accession>
    <name>A0A0F4JBP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_18740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000513">
        <property type="protein sequence ID" value="KJY31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948685.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000513.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY31163">
        <property type="protein sequence ID" value="KJY31163"/>
        <property type="gene ID" value="VR44_18740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8359"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="269"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="440" mass="47115" checksum="E3553B4ED327CEF8" modified="2015-06-24" version="1" fragment="single">MNSVPRDGAGDRLAEFHELRERVRRGPGEQATAAQHAKGKLTARERIALLLDEGSFHEVEPLRRHRATGFGLEDKKPYTDGVITGWGTVDGRTVFTYAHDFRIFGGALGEAHAQKIHKIMDMALAAGAPLVSLNDGAGARIQEGVTALAGYGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVRAVTGEEISQNGLGGADVHASVSGVSHFAYDDEQTCIEEVRYLLSLLPRNNQESPPAVTGGDAADRRCEALNTLVPADGNRPYDMREVIAEIVDDGEFLEVHERWATNVLCALARVDGHTVGVVANQPQSLAGVLDIDASDKAARFVQLCDAFNIPLVTLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCAATVPRVQLILRKAYGGAYIVMDSRSIGADLSFAWPTNEIAVMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JDE2</accession>
    <name>A0A0F4JDE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_17340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JZWV01000462">
        <property type="protein sequence ID" value="KJY31834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948416.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000462.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000019_gene7386"/>
    <dbReference type="EnsemblBacteria" id="KJY31834">
        <property type="protein sequence ID" value="KJY31834"/>
        <property type="gene ID" value="VR44_17340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.8003"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="189"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY31834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="547" mass="60784" checksum="890578FD45CD6908" modified="2015-06-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JFB7</accession>
    <name>A0A0F4JFB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_14640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000376">
        <property type="protein sequence ID" value="KJY33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947916.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33027">
        <property type="protein sequence ID" value="KJY33027"/>
        <property type="gene ID" value="VR44_14640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7255"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="379" mass="40688" checksum="559803D41EB29808" modified="2015-06-24" version="1">MHQYSQQSSGREPERAGGRRKSRRAIWIGAAVAGVLVLGGGGFAAYKNEWFDGNGQDVTFGKDHAAAAASGKDGAGPAGKGATPSAPPTPTGDPDVQLPAGPKSDFKQTTKLDDGTVIAKTRLAGAKSGFEGDVWVWAPKEYDDPKYAKSAFPVLIALPGGNGFPANYWSDRSLGLQKAISEGVQAGTSLPFVVIMPVLNPDNKYYYDGADIPGQPKMGTWIAEDVPDFARANFRTYKSRDGWAFMGSSSGAFVGMKTVLQYPDRFKAVIASGGEIVPDSPLWKGHQAEMDANNPEKLADKLIRTGGPDVYINFQIGTKESGKDRMTKFVEQYGKGPVKTTIRDIQNGEHNGWHYVRGMKEGSLEWISKVLKGPKPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JG05</accession>
    <name>A0A0F4JG05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_15440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000398">
        <property type="protein sequence ID" value="KJY32688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045948058.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000398.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY32688">
        <property type="protein sequence ID" value="KJY32688"/>
        <property type="gene ID" value="VR44_15440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7489"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY32688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="122" mass="12639" checksum="F7DDA394F05F785F" modified="2015-06-24" version="1">MLDALTAALGVAALALAAWCGHAVWRDQPTKDWHFIGMAVVTLLALAQLVVGLVQLGRGEKPEQGTVLFVAYLLGAFAAVPAAGLLSLTERTKWGSVTVAAGAVVLAVLEVRLYDIWGSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JI43</accession>
    <name>A0A0F4JI43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000330">
        <property type="protein sequence ID" value="KJY33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947625.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000330.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33890">
        <property type="protein sequence ID" value="KJY33890"/>
        <property type="gene ID" value="VR44_13020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6722"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="228" mass="24831" checksum="4E62CF2DBA7C8EAC" modified="2015-06-24" version="1">MTSEPRPSGAMRYVLFDVDGTLVDALDNQRLVWRTWAERYGLDPDEVHRVALRTRPMETFAQIAPDQDPHECLAALHELEDEDVRTGTYGAFDGAPELLRALRPGTWALVTSNYEHRVRGRFARTGLPVPEVVVDAAAVAEGKPSPVPYLQAAARLGARPEDCLVIEDAPSGVQAGLRAGMTVWGVNTPTAVDGVHRHFATLREAADAVLAFASGSLPGRPERAGWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIF9</accession>
    <name>A0A0F4JIF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000352">
        <property type="protein sequence ID" value="KJY33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33553">
        <property type="protein sequence ID" value="KJY33553"/>
        <property type="gene ID" value="VR44_13740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7024"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="10440" checksum="D808EC538F792257" modified="2015-06-24" version="1">MEYDERSTVRHTHHGPVGMSTARPHRSRRASSTSCWQYLGRVIQQIERDPGALLQTGVDLRPGMEHSFTICSRIDRYGRDSRPFLEHTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JIK3</accession>
    <name>A0A0F4JIK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_12490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000310">
        <property type="protein sequence ID" value="KJY34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34177">
        <property type="protein sequence ID" value="KJY34177"/>
        <property type="gene ID" value="VR44_12490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6558"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="152"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="38361" checksum="46CA38F8DFA7D9B3" modified="2015-06-24" version="1">MSYVTSGREFSRDERYLTTRITADGRDGFPVEPGRYRLVVSRACPWANRAIIVRRLLGLEEALPMAVAGPVHDERSWTFDLDPGGRDPVLGIERLQEAYFARDPGYDRGITVPAVVDVPTGQVVTNDFPQITLDLSLEWTAHHRPGAPALYPSELRAQIDSVNEAVYRDVNNGVYRAGFAGSQEAYERAYRRLFERLDRLSERLTGSRYLVGDTITEADVRLFTTLVRFDAVYHGHFKCNRHKLSEMPVLWDYARDLFQTPGFGDTIDFDHIKRHYYLVHTDINPTGIVPAGPDARSWLAPHGRAALGGRPFGDGTPPGPVPPGEAVPPGHNPLVREGSSPLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK47</accession>
    <name>A0A0F4JK47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000308">
        <property type="protein sequence ID" value="KJY34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34194">
        <property type="protein sequence ID" value="KJY34194"/>
        <property type="gene ID" value="VR44_12395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="141" mass="15796" checksum="C61F89060DEDA50A" modified="2015-06-24" version="1" fragment="single">MSVPEKVYEGWNSHDGWDNYTRWGEEFGENGVPWCVIFDWCMYHDVGLDAIVPKVDNVSAFASWARARGQWSDYPSVGAWVDFGDGAHTEIVTGFDADTVYTKGGNSIRSGSEDHGQGNGVWSHSNPRRSSYVTGYFAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JK96</accession>
    <name>A0A0F4JK96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_12300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000304">
        <property type="protein sequence ID" value="KJY34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947491.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000304.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34239">
        <property type="protein sequence ID" value="KJY34239"/>
        <property type="gene ID" value="VR44_12300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6444"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002471011" evidence="2">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="69" mass="6562" checksum="52C9061DC11AAEDA" modified="2015-06-24" version="1">MRSARRGAALAALAAGAVLLLTGCGGGGNAHPKAEQSAGADGQAADMQAKLDAAENAAAQADADASQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKB5</accession>
    <name>A0A0F4JKB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000302">
        <property type="protein sequence ID" value="KJY34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947483.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000302.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34259">
        <property type="protein sequence ID" value="KJY34259"/>
        <property type="gene ID" value="VR44_12255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6433"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="16"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="224" mass="23478" checksum="DEEE770BD7A563F5" modified="2015-06-24" version="1">MSDTYDDAGDGERGRRLVAAAEQLFTAGVMSHSGHANLSARLDGERLLLTPGHVRGLRAEQLATVGFDGQVLEGELRSVSAEIIAMHTAVYRARPHVGTVIHTHSPSATAFALAHRPLPCRTEPMLRFGQAEEVPVVPWGPRGSDVSVRGIAEVLDRCPTTAAVLLANHGLLVFGPDPEATAHLVVAIEESAEAEIAAAAIGGAVDFPPGAQEAVRAAIARVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JKM6</accession>
    <name>A0A0F4JKM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_13795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000354">
        <property type="protein sequence ID" value="KJY33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947765.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000354.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33496">
        <property type="protein sequence ID" value="KJY33496"/>
        <property type="gene ID" value="VR44_13795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.7038"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043869">
        <property type="entry name" value="DUF5829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19147">
        <property type="entry name" value="DUF5829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470824" evidence="1">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="32819" checksum="FD40A3683764B9F9" modified="2015-06-24" version="1">MFMILAVALAGWAGGTSGIASALEEGPPPTARQLLFFNHAYGVLDRETADAIEHSAYLRDFADFQVRTTTGSGGETWTGRYLRGRETYLELFGVGDVPGQDGTLGAGGMGISAERAGDLATVTARLHDQGVPNPITFRQTRDFGDGIPVPWFDAVFTTGQYDGFGAWGMEYLPEYFADPRSNTEPASYPGDVGRERYLPDGYRDHLMRDVTSIRLAVTARDLAATLPLLRAGGFTVRELPNGSALAQGGGTTIHLDPVAREQAGLREVEMSLNHPVAYRHEERIGHSTLVVGPGDRAVWTFGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLE7</accession>
    <name>A0A0F4JLE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_13240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000337">
        <property type="protein sequence ID" value="KJY33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947665.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000337.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY33791">
        <property type="protein sequence ID" value="KJY33791"/>
        <property type="gene ID" value="VR44_13240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6867"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="416" mass="45383" checksum="CB39B1D5D23F48BB" modified="2015-06-24" version="1">MEQFEPDRLSAAQLAAMRRSLTSGRGALTRRSLLRASGAGALTLGGLAALTACGIPPAKREGGQAAPSDDHSEQEKEINFSNWTEYMDTSDDEKSRPTLDAFTKRTGIEVKYTEDINDNVEFFGKIRPQLAAGQDTGRDLIVVTDWLAARIIRLGWAQKLDPSHLPNAYANLIPQFRNPDWDPGRAHSYPWTGIDTVIAYNAKATGGKKVDSVTQLLDDPTLKGRVGFLTEMRDTVGMTLLDQGKDPAKFTTADYDAAIGRLQKGVDTKQIRRFTGNDYTADLDKGDLAACIAWAGDVIQLQAGNPDIKYAIPAAGYITSSDNLLVPAKARHKANAEKLIDYYYEPAVAAQLAAFISYVCPVDGVKDELARIKPELADNPLIVPDKEMAAKAHAFRSLTSEEETAYEEKFAKLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JLW1</accession>
    <name>A0A0F4JLW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_11275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000261">
        <property type="protein sequence ID" value="KJY34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34814">
        <property type="protein sequence ID" value="KJY34814"/>
        <property type="gene ID" value="VR44_11275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="60" mass="6216" checksum="36594698FA1280EE" modified="2015-06-24" version="1" fragment="single">MWKSYGARSVLRGVNVTVEPGTLLGVTGGNGAGKTTLLRTMVGELAPDEGAVHRDGEIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JM75</accession>
    <name>A0A0F4JM75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_12705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000318">
        <property type="protein sequence ID" value="KJY34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34041">
        <property type="protein sequence ID" value="KJY34041"/>
        <property type="gene ID" value="VR44_12705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="425" mass="45189" checksum="E1AE2945F9BAC0EE" modified="2015-06-24" version="1" fragment="single">MLGSAFAALVTAVAVCSGDAVARVFPYGPRHRSVNDLGNQFVPFHAHLWDLLHGRARGGLLFNWQSGYGTSFLPDLGTYLSSPFALLVGVFPRPDIDLAVYVVTVLKMTAAAAAMAWLLRAQRPGPWWAAGLLGASYALCGWSVIEASYNPMWLDGLIAFPLLCLTGEWALRGRRPLLGVLVVAVCWTANFYTAYMATLGAALVLVVRVVLTRDGVRERALVIGRAAVTTVLGMALTAPLLVPLFLSSQQAYPGWSKEFAPVPWSDLFARLLPATYSFGSPAVFVGTGTLLLVTALPFHRALPLRTRLWWAGLVAAVLLSLQWEPTHLAWHVFATPNGSPYRQTFVLAGILVIAAWTGLAAGLPGVRALAAGAGVLAAAAAWAAGSALATGWGYALFCGGLALAAGAWWALRHRRLLLPAAARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JML0</accession>
    <name>A0A0F4JML0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_09715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000211">
        <property type="protein sequence ID" value="KJY35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947012.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000004_gene3673"/>
    <dbReference type="EnsemblBacteria" id="KJY35602">
        <property type="protein sequence ID" value="KJY35602"/>
        <property type="gene ID" value="VR44_09715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5443"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="83" mass="8813" checksum="1729DECAF00F29F7" modified="2015-06-24" version="1">MVRTPLTPEERERGERLGALLREARGGRSMVEVAAGAGLSPETLRKIETGRAPTPAFFTVAALAEALGLSLDEVVRRCALVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JMY6</accession>
    <name>A0A0F4JMY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_10810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000243">
        <property type="protein sequence ID" value="KJY35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947213.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000243.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000035_gene3389"/>
    <dbReference type="EnsemblBacteria" id="KJY35113">
        <property type="protein sequence ID" value="KJY35113"/>
        <property type="gene ID" value="VR44_10810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6012"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="305" mass="32184" checksum="0C95CCD6412F84D1" modified="2015-06-24" version="1">MTADSASERRYARALSSLRGLALGDALGSQYFVPVNLPLLKRRELPAGSEPWQWTDDTEMACSVVAVLAAHGRIDQDALASSFAEHHDFDRGYGPAVNRMLRLVREGEDWRTLAAELFNGQGSWGNGAAMRIAPLGAWYAEDPEQATHQAEISAYTTHQHREAVCGAMAVAAAAALAGAPAGPPSAEELLDGVIALVPRSAVGAGVRRARDMLDYGDANTVAAVLGCGRRTSAHDTVPFALWSAARALDDFERAFWTTAQVGGDVDTTCAIVGGILGARGDAALPPAWLARTEALPAWLPETPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JNK7</accession>
    <name>A0A0F4JNK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_11695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000282">
        <property type="protein sequence ID" value="KJY34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045947375.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY34506">
        <property type="protein sequence ID" value="KJY34506"/>
        <property type="gene ID" value="VR44_11695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.6305"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="134"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="427" mass="44640" checksum="ABF2F49029006A1A" modified="2015-06-24" version="1">MPPAPAVPPLSKPRTEVVGNFGVADRRSSAVIGFRKAGKDRAARRRVRRLAGAGMVVPLAAGALLFGGAGPAAAGPGTGPTAVVSMGDSYISGEAGRWKGNSLTNSGSRNGTDRAWVSGSTYDPAKVYGTTAGGCDRSDSAEVLSAGAVAETAVNLACSGATSQNVFRASNGGVSYKGEAPQADQLAAVAASRNVKVIALSVGGNDLGFADIIKECALDFVLWNSYCYDDQQAGVDAKIDGVMANVGKSVDEIRAVMRQAGYTDSSYRIVLQSYPSPIPRGAENRYTQSDWSRLNSGGCPFWNRDSDWARDSLVPQLADRLKQVAAAKGTQFLDLRDMMQGREVCAKASKQVTSTVPASAKTSEWARWIDNNETQGLVQESMHPNHFGQLALGRCLALAVAQPADSASSCKNTAGGDQSGMYLTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JPG6</accession>
    <name>A0A0F4JPG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_08765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000181">
        <property type="protein sequence ID" value="KJY36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36070">
        <property type="protein sequence ID" value="KJY36070"/>
        <property type="gene ID" value="VR44_08765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4997"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="180" mass="19284" checksum="3561577A8C897ED0" modified="2015-06-24" version="1" fragment="single">MTAAREQARDIVVGVDPVRDWHLAVAWAADEAHRRRLPLRPVLAVPPQHDTPHVDDTERQTALRRGGADRLDQAAAWVGERHPEVTVHTDLLGGFPAHVLLAQSRHARLVVLGSRHLGRAAELFSSGSTVVPVTAQAACPVAVVGDAEHATQQPAYLVVGIDGSAATTDALTFAFDEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQG6</accession>
    <name>A0A0F4JQG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leupeptin-inactivating enzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VR44_08590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000178">
        <property type="protein sequence ID" value="KJY36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946800.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000178.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36094">
        <property type="protein sequence ID" value="KJY36094"/>
        <property type="gene ID" value="VR44_08590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4860"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002470780" evidence="5">
        <location>
            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="6">
        <location>
            <begin position="332"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJY36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="450" mass="46275" checksum="5E83F9D50A9D0F6C" modified="2015-06-24" version="1">MSLSVSRRLAAVTAIAVAGLFASTAPAALAAAPSAATAVPAAAPAAVAAPTPPDIPLTNVKAHLAQFQSIANANSGNRAHGRAGYKASIDYVKAKLDAAGFTTTLQTFTSSGATGYNLIADWPGGDPNSVLMSGSHLDSVTAGPGINDNGSGSAAVLETALAVSRAQLQPTKHLRFGWWGAEELGLVGSQYYVNSLPAAEKSKISGYLNFDMIGSPNPGYFVYDDDPTIEQTFKTYFAGLNIPTEIETEGDGRSDHAPFKNAGVPVGGLFSGADYTKTAAQAQKWGGTSGRAFDACYHASCDTASNIDDTALDRNSDAIAYAVWNLGAATPVPPGPSFENTADVNIPDSPGAAATSPITVSGVSGNAPATTKVDVNIVHTYRGDLVIDLIAPDGTAYRLKNSSSSDSADNVVASYTVNASSEVANGVWKLQVKDVAAQDTGYINSWKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQN4</accession>
    <name>A0A0F4JQN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000158">
        <property type="protein sequence ID" value="KJY36485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946676.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000158.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36485">
        <property type="protein sequence ID" value="KJY36485"/>
        <property type="gene ID" value="VR44_07925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4406"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="152" mass="17099" checksum="E51C7A0F30AEE7B7" modified="2015-06-24" version="1">MVESVPVGVVVGGRTDVVDDDWGRERAVIRLDSGLFGPEALHGLEDFSHVEVVYHFDRVPVEKIETGARHPRGNRDWPLVGIFAQRGKNRPNRLGVSRCRVVRVEGLDVHVEGLDAVDGTPVLDLKPYMAEFAPRGEVRQPEWATVLMRDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JQX0</accession>
    <name>A0A0F4JQX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_07645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000149">
        <property type="protein sequence ID" value="KJY36575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946621.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36575">
        <property type="protein sequence ID" value="KJY36575"/>
        <property type="gene ID" value="VR44_07645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.4141"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY36575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="348" mass="36903" checksum="AD3700ECCC135ED8" modified="2015-06-24" version="1">MSVTQAAAYAAPAPKAPLERTTVPRRPVGEHDVLIEVKYAGICHSDIHQARDGWGEGIFPMVPGHEIAGVVAEVGPGVTKYAVGDRVGVGCFVDSCRECEYCLAGQEQHCVQGATGTYNALDRNGEPTYGGYSTHLVVDENYAVRIPEGLALDVAAPLLCAGITLYSPLKHWGAGPGKKVAIVGLGGLGHMGVKIAHALGAEVTVLSQSLRKREDGLRLGADHYYATADEATFKELKGRFDLILSTVSAPLGLDRYLSLLRVGGALVNVGAPEEPVELNLFSVIAGNRTLAGSMIGGIAETQEMLDFCAEHGLGSEIEVISGDQINEAYERVLSSDVRYRFVIDTSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JR84</accession>
    <name>A0A0F4JR84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VR44_07465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="JZWV01000145">
        <property type="protein sequence ID" value="KJY36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946583.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000145.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000045_gene2255"/>
    <dbReference type="EnsemblBacteria" id="KJY36700">
        <property type="protein sequence ID" value="KJY36700"/>
        <property type="gene ID" value="VR44_07465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3968"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJY36700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="300" mass="32973" checksum="ACD971CD80D8327D" modified="2015-06-24" version="1">MTQSHPVIKKAVIPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEAVSAGLDDVLMITGRNKRPLEDHFDRNYELESALIAKGDDDRLKKVQESSDLATMHYVRQGDPRGLGHAVLCAEPHVGDEPFAVLLGDDLIDPRDPLLRRMVDVHEHTGGTVIALMEVDPAHVHLYGCAAVEATGEDDVVRITGLVEKPEPAEAPSNYAVIGRYVLHPAIFGILRETEPGRGGEIQLTDALQKLAADESVGGPVHGVVFRGRRYDTGDRGDYLRAIVRLACEREDLGPEFRTWLHRYVTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JRI4</accession>
    <name>A0A0F4JRI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_09915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000214">
        <property type="protein sequence ID" value="KJY35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000026_gene7044"/>
    <dbReference type="EnsemblBacteria" id="KJY35541">
        <property type="protein sequence ID" value="KJY35541"/>
        <property type="gene ID" value="VR44_09915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5532"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="63" mass="6306" checksum="BCFC4CCB49E91DE0" modified="2015-06-24" version="1" fragment="single">RQAKDTPVPSTGGKITPSQAPHAAPAVDKGDGSSWTWIALGLGACVLIGGAVTAVVVRRAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS14</accession>
    <name>A0A0F4JS14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_06445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000118">
        <property type="protein sequence ID" value="KJY37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946403.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37157">
        <property type="protein sequence ID" value="KJY37157"/>
        <property type="gene ID" value="VR44_06445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3201"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="118" mass="13574" checksum="6DC866629E438EB6" modified="2015-06-24" version="1">MNDDGRIFREAWITGVKKHFPGEPKPGYITPWDDTPDWERQSAAAVYGQVRDFITVSGGHTSKLSREQKGRFVALCWIAQIHKHIPDPKPGYVADWDALPEWQQETDADIFEHIEQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS51</accession>
    <name>A0A0F4JS51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_06305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000117">
        <property type="protein sequence ID" value="KJY37197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946374.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000029_gene66"/>
    <dbReference type="EnsemblBacteria" id="KJY37197">
        <property type="protein sequence ID" value="KJY37197"/>
        <property type="gene ID" value="VR44_06305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3015"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="180"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="347" mass="35826" checksum="1BF40F44A4523A7F" modified="2015-06-24" version="1">MRATVIHAPHDIRVEEVPDAAIQRPEDAVVRVLRACICGSDLWAYRGEAQRQPGQRIGHEFLGVVEETGSAVSGLKAGDLVVAPFMWSDGTCDYCSEGLYTSCVHGGFWGSVGFDGGQGEAVRVPHADGTLVKLPAAAASDDHLLTGLLALSDVMGTGHHAALGAGVRAGSTVAVVGDGAVGLCGVLAAKRLGAERIIALGRHSARTDIAKLFGATDVVAERGEAAEAAVRELTGGQGAHAVIEAVGTEQSMRTAVNITRDGGAIGYVGVPHGSGTGLDLGVMFDRNISLRGGVAPVRAYIPELLEDVLSGAIDPAPVFDRAVSLDEVPDGYRAMDDRSALKVLIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JS61</accession>
    <name>A0A0F4JS61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_09220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000199">
        <property type="protein sequence ID" value="KJY35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY35791">
        <property type="protein sequence ID" value="KJY35791"/>
        <property type="gene ID" value="VR44_09220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.5108"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="182" mass="20833" checksum="E67F230E61007FF2" modified="2015-06-24" version="1">MSAGPSQPRDPQAPKGRPTPKRAVAQSQRKAVVASTGNRKEDARRARERRREEMARQREALANGDERYLPTRDKGPVRRFVRDFVDSRYSVAEMFLPLAVIILVLSMIRVNSIQTVALTLWLVVIVLIVLDSIGLAFRLRKALNERFPNEPRRGAVAYGLMRTLQMRRLRLPKPQVKRGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JSP2</accession>
    <name>A0A0F4JSP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VR44_07245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000137">
        <property type="protein sequence ID" value="KJY36783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY36783">
        <property type="protein sequence ID" value="KJY36783"/>
        <property type="gene ID" value="VR44_07245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.3790"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJY36783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="113" mass="11893" checksum="1263FBE39A86BCAD" modified="2015-06-24" version="1" fragment="single">ARALARRTGGRPAARAVSRYAADAAALALLRRQARHAGPGGDPGFAERERELLRRLWLRRGTAGPALARAAVLEELLPVRPGPPAAAPARHARRALPVAVPAPRRAELSAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTN5</accession>
    <name>A0A0F4JTN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VR44_05120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000095">
        <property type="protein sequence ID" value="KJY37727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946155.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37727">
        <property type="protein sequence ID" value="KJY37727"/>
        <property type="gene ID" value="VR44_05120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1339"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJY37727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="344" mass="35822" checksum="52B1A82099C61FB3" modified="2015-06-24" version="1">MPRGRHRNPEPLHRLLTPTAVGGVSVASAGAAWLLAEPLALRLLVALTAAAGVGGAVLMRSWDRAAGRRVAELARERVKDEWKTDERIAELESDLEEARVLRAKLDAKLRAKRVELAGLRGEHAALLRRYATAETERASALEKRRLLAMENAGTPKELPAVSQERTGSGAPTAVGYARANAAMAALLRKAEARAAAEAAAAAGPKALAPAAGPAHARTEAPAGSAPAPASAPVPARRPAAPVAPYAAQRRSASRVEGGFDFFGTKNTAQARAAIESVQNEDLADVVGAEALAAHKAESAEGGAEPESKPVTEEQQEAAAGQVIDLTAHDETEPIDVVRLRTAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JTZ4</accession>
    <name>A0A0F4JTZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_06195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000115">
        <property type="protein sequence ID" value="KJY37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946353.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000115.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37228">
        <property type="protein sequence ID" value="KJY37228"/>
        <property type="gene ID" value="VR44_06195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.2992"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="268" mass="28716" checksum="EE11E5FE596A7E96" modified="2015-06-24" version="1">MTRSVLITGGSGGIGRACVERFAREEDWTVWFTYRNGRARAEELVRELALTGRAKVEAFPFAQGDWEEHELLLGRLPGPVDVLVNNAAVGSKTVEHYTEGPGHEKASAFFQINAVGPLWLTEQLLPGMLERGFGKIINISSVGGGIFQFPGFHPADGMSKAALTYLTRHLAADLAHSPVDVFALCPGAVDTTMFQASTLDKLSSEERAALSARLPKGRMITSAEIAEQVRWLAGEHSTPLHGAVIDASMGLGVHPGLLTGADVDSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JU27</accession>
    <name>A0A0F4JU27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VR44_05270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946177.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37665">
        <property type="protein sequence ID" value="KJY37665"/>
        <property type="gene ID" value="VR44_05270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1688"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJY37665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="120" mass="13028" checksum="992EF45D9CCE5A66" modified="2015-06-24" version="1">MTLDPQPLAPALASAEEAGWTTVRLDLDGVRSKAALMRRCAAALRVPEWFGGNWDALADALIDLSWLPDAPGRLLAVTSWRGYAAERAEDWETLGEVLEEAVDFWRGQRGAPPLTVVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JV03</accession>
    <name>A0A0F4JV03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger UBP-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VR44_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000097">
        <property type="protein sequence ID" value="KJY37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045946181.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KJY37669">
        <property type="protein sequence ID" value="KJY37669"/>
        <property type="gene ID" value="VR44_05295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.1693"/>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJY37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033551"/>
        </source>
    </evidence>
    <sequence length="90" mass="10074" checksum="129D1B057FC8CB9A" modified="2015-06-24" version="1">MTKDLLCTHVDQIRPVKPSADGCEECLRLGDAWVHLRMCLSCGHVGCCDSSKNRHATRHYRATAHPIAASHEPGEDWAWCYADQLMLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-06-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F4JVG0</accession>
    <name>A0A0F4JVG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VR44_04125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katrae</name>
        <dbReference type="NCBI Taxonomy" id="68223"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ju K.-S."/>
                <person name="Doroghazi J.R."/>
                <person name="Metcalf W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL ISP-5550</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JZWV01000076">
        <property type="protein sequence ID" value="KJY38145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045945973.1">
        <property type="nucleotide sequence ID" value="NZ_JZWV01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="68223.JNZY01000016_gene821"/>
    <dbReference type="EnsemblBacteria" id="KJY38145">
        <property type="protein sequence ID" value="KJY38145"/>
        <property type="gene ID" value="VR44_04125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|68223.7.peg.113"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033551">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <pro